Patents Issued in June 15, 2017
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Publication number: 20170166498Abstract: A process for the isomerization of a para-xylene depleted, meta-xylene rich stream under at least partially liquid phase conditions using ZSM-23 with an external surface area of at least 75 m2/g (indicating a small crystallite size), and a SiO2/Al2O3 ratio between 15 and 75 that produces a higher than equilibrium amount of para-xylene, i.e., more than about 24 wt % of para-xylene, based on the total amount of xylenes.Type: ApplicationFiled: October 18, 2016Publication date: June 15, 2017Inventors: Brian M. Weiss, Darryl D. Lacy, Scott J. Weigel
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Publication number: 20170166499Abstract: The invention relates to a method for operating a dehydrogenation reactor for the dehydrogenation of hydrocarbons is provided wherein the dehydrogenation reactor comprises a potassium promoted iron oxide catalyst, the hydrocarbons being dehydrogenated in contact with the catalyst and carbon dioxide is introduced during a) start-up of the reactor, b) shut-down of the reactor, and c) steaming procedures, wherein the carbon dioxide is introduced in conjunction with steam in at least one method step.Type: ApplicationFiled: February 11, 2015Publication date: June 15, 2017Inventors: Michael L. MILLER, Timothy A. BROWN, Clay SHAFER
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Publication number: 20170166500Abstract: The instant invention relates to a process and method for manufacturing 2,3,3,3-tetrafluoropropene by dehydrohalogenating a reactant stream of 2-chloro-1,1,1,2-tetrafluoropropane that is substantially free from impurities, particularly halogenated propanes, propenes, and propynes.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Inventors: Daniel C. Merkel, Konstantin A. Pokrovski, Hsueh S. Tung, Haiyou Wang
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Publication number: 20170166501Abstract: A process for preparing trifluorochloroethylene including: in a multi-tubular reactor, hydrogenation reacting 1,1,2-trifluoro-1,2,2-trichloroethane directly with a catalyst potassium zinc trihydride to obtain trifluorochloroethylene, wherein the catalytic reaction is performed at a temperature of 250-350° C. and a pressure of 0.7-1.0 MPa for 10-20 seconds. The conventional process in which zinc powder is used for dechlorination or hydrogen is used for dechlorination through hydrogenation with the action of a noble metal catalyst is avoided in the process disclosed herein. The present process substantially reduces the production cost of trifluorochloroethylene, and substantially increases the product yield, which can be up to 99% or more.Type: ApplicationFiled: December 9, 2014Publication date: June 15, 2017Inventors: Linxu SI, Pingzhong ZHANG, Hexiang GU
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Publication number: 20170166502Abstract: A method of extending the catalyst life of a hydrogenolysis catalyst activity in the presence of biomass and aqueous solution is described. Lignocellulosic biomass solids and aqueous solution is provided to in a hydrothermal digestion unit in the presence of a digestive solvent, and a supported hydrogenolysis catalyst containing (a) sulfur, (b) Mo or W, and (c) Co, Ni or mixture thereof, incorporated into a solid metal oxide support. The lignocellulosic biomass solids in the hydrothermal digestion unit is heated to a temperature in the range of 180° C. to less than 300° C. in the presence of digestive solvent, hydrogen, and in the range of 0.15 wt. % to 12.5 wt. %, based on catalyst, of H2S or H2S source at least partially soluble in aqueous solution, and the supported hydrogenolysis catalyst forming a product solution containing plurality of oxygenated hydrocarbons, the hydrothermal digestion unit maintaining protective sulfur concentration.Type: ApplicationFiled: December 14, 2016Publication date: June 15, 2017Inventors: Andries Quirin Maria BOON, Joseph Broun POWELL
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Publication number: 20170166503Abstract: Method and device for providing and using a methanol-containing liquid.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventor: Peter Grauer
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Publication number: 20170166504Abstract: A method of preparing 4-methyl-3-decen-5-one. The method includes the step of oxidizing 4-methyl-3-decen-5-ol in the presence of (i) oxygen and (ii) a metal catalyst, wherein the metal catalyst contains a catalytic metal deposited on nanoparticle support.Type: ApplicationFiled: December 12, 2016Publication date: June 15, 2017Inventors: Avelino Corma Canós, Sara Iborra Chornet, Alexandra Velty, Manuel Querol Sans, Amadeo Fernández Miranda, Jaime Renovell Gomez
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Publication number: 20170166505Abstract: The present invention relates to a pharmaceutical composition or a functional health food comprising a verbenone derivative and pharmaceutically acceptable salts thereof as active ingredients for treating or preventing a neurodegenerative disease. More specifically, the verbenone derivative according to the present invention reduces neuronal cell death and oxidative stress, and is highly effective in preventing ischemic brain damage and inflammatory cell migration in rats, thereby providing the pharmaceutical composition or the functional health food which is useful in treating neurodegenerative diseases.Type: ApplicationFiled: February 14, 2017Publication date: June 15, 2017Inventors: Won Ki Kim, Yongseok Choi, Sumi Song
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Publication number: 20170166506Abstract: This disclosure provides for routes of synthesis of acrylic acid and other ?,?-unsaturated carboxylic acids and their salts, including catalytic methods. For example, there is provided a process for producing an ?,?-unsaturated carboxylic acid or a salt thereof, the process comprising: (1) contacting in any order, a group 8-11 transition metal precursor, an olefin, carbon dioxide, a diluent, and a polyaromatic resin with associated metal cations to provide a reaction mixture; and (2) applying conditions to the reaction mixture suitable to produce the ?,?-unsaturated carboxylic acid or a salt thereof. Methods of regenerating the polyaromatic resin with associated metal cations are described.Type: ApplicationFiled: December 13, 2016Publication date: June 15, 2017Applicant: Chevron Phillips Chemical Company LPInventors: Pasquale Iacono, Mark L. Hlavinka
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Publication number: 20170166507Abstract: The present invention relates to the manufacture of biobased acrylic acid from glycerol as starting material, the term “biobased acid” indicating that the acrylic acid is essentially based on a carbon source of natural origin.Type: ApplicationFiled: February 16, 2015Publication date: June 15, 2017Inventors: Jean-Francois DEVAUX, Michel FAUCONET, Sandeep JAIN, Stephen TLATLIK
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Publication number: 20170166508Abstract: The present disclosure provides a process for recovering and recycling a catalyst from the mother liquor generated during the production of aromatic carboxylic acids. The process comprises treating the mother liquor with an alkyl aromatic compound and further treating the first aqueous layer obtained with an ionic liquid to obtain a catalyst rich aqueous mixture. The catalyst rich aqueous mixture is recycled to the oxidation reactor.Type: ApplicationFiled: February 19, 2015Publication date: June 15, 2017Applicant: Reliance Industries LimitedInventors: Suresh Shantilal Jain, Pavankumar Aduri, Vivek Shankaranarayanan, Parasuveera Uppara
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Publication number: 20170166509Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves recirculating acetylation fluid recovered from wood acetylation to a unit for the production of acetic anhydride from acetic acid and ketene. The acetic anhydride product stream can, in turn, be directly used as a wood acetylation fluid.Type: ApplicationFiled: July 17, 2015Publication date: June 15, 2017Inventors: Stephen John Benstead, Benjamin Thomas Painter
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Publication number: 20170166510Abstract: This invention provides a compound that is 4,4?-(4?-Carboxy)-4-nonyloxy-[1,1?-biphenyl]-3,5-diyl)dibutanoic acid (CNBDA), derivative compounds of CNBDA, and pharmaceutical compositions thereof. The derivative compounds of CNBDA have one or more of the following substitutions (a) replacement of one or both of the carboxylic acid groups of the CNBDA compound with an organic acid group having 1-3, or 5-30, or more carbon atoms in chain length, wherein the carbon atom chains are either saturated, partially saturated, or unsaturated with respect to the carbon to carbon bonding, (b) replacement of the carboxylic groups of (a) with a phosphate, a sulphate, an amide, a hydroxyl, an aldehyde, or a halide group, and (c) replacement of the nonane group with an alkane having a carbon chain length of 1-8 or 10-30, or more carbon atoms. A method of treating a patient having cancer is provided.Type: ApplicationFiled: December 7, 2016Publication date: June 15, 2017Inventors: Yehenew Agazie, Zachary Hartman
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Publication number: 20170166511Abstract: A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.Type: ApplicationFiled: November 19, 2014Publication date: June 15, 2017Applicant: WACKER CHEMIE AGInventors: PETER GIGLER, JÜRGEN STOHRER
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Publication number: 20170166512Abstract: The present invention relates to a method for the chemical conversion of an unsaturated fatty acid, particularly a carbon chain extension reaction. According to the present invention, a method for extending the length of a carbon chain in an unsaturated fatty acid by two carbon atoms is provided, said method comprising a step of heating a malonic acid ester derivative of an unsaturated fatty acid to reflux in a lower fatty acid solution in the presence of an antioxidative agent. It is preferred that the unsaturated fatty acid is an unsaturated fatty acid having 16 to 24 carbon atoms. It is preferred that the unsaturated fatty acid is selected from the group consisting of linoleic acid, linolenic acid, arachidonic acid, stearidonic acid, icosatetraenoic acid, icosapentaenoic acid, tetracosahexaenoic acid and docosahexaenoic acid. According to the method of the present invention, a carbon chain extension reaction can be completed within a shorter time.Type: ApplicationFiled: January 14, 2015Publication date: June 15, 2017Applicant: Bizen Chemical Co., Ltd.Inventors: Yoshio Shimizu, Naomichi Bamba, Mitsumasa Mankura
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Publication number: 20170166513Abstract: The present invention relates to an epoxy resin curing agent having a structure of Formula I and preparation methods and uses thereof. The present invention makes a resin composition formed by the epoxy resin curing agent have good low dielectric properties by using an epoxy resin curing agent having a specific structure, and the cured products of the epoxy resin composition have low dielectric constant and dielectric loss and good heat resistance and are low dielectric materials having great economic properties and being environmental friendly.Type: ApplicationFiled: April 15, 2016Publication date: June 15, 2017Inventor: Qingchong Pan
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Publication number: 20170166514Abstract: The present invention relates to a method for purifying raw dinitrotoluenes resulting from dinitration of toluene in the presence of a nitric acid/sulfuric acid/nitrating acid mixture, and a device or plant for performing the method, and a corresponding production plant for producing dinitrotoluene, characterized in that (a) the raw dinitrotoluenes are first subjected to a wash with at least one washing medium after separation of the nitrating acid mixture, followed by a separation of the washing medium; and that (b) subsequently the washed dinitrotoluenes resulting from method step (a) are subjected to stripping (stripping gas treatment) with at least one gas (stripping gas).Type: ApplicationFiled: April 30, 2015Publication date: June 15, 2017Inventors: Dr. Jürgen PÖHLMANN, Dr. Heinrich HERMANN, Dr. Mirko HÄNDEL, Jürgen GEBAUER, Tim BERGMANN
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Publication number: 20170166515Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.Type: ApplicationFiled: February 9, 2017Publication date: June 15, 2017Inventors: Andreas FISCHER, Helmut BUSCHMANN, Michael GRUSS, Dagmar LISCHKE
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Publication number: 20170166516Abstract: The present disclosure relates to Tapentadol Hydrochloride in the polymorphic crystalline Form B, which is substantially free of polymorphic Form A as well as essentially free of low alkyl carboxylic acids or esters of such acids. Furthermore, the present disclosure provides a process to produce this polymorphic Form B substantially free of Form A and its preparation and use for pharmaceutical compositions. This process as well as the specific crystalline form is uncommon, improved and industrially advantageous. Furthermore, the disclosure relates to pharmaceutical compositions and uses thereof.Type: ApplicationFiled: February 10, 2015Publication date: June 15, 2017Inventors: Dominique Anna BOCK, Thomas MAIER, Sven HAFERKAMP, Frank PORSTMANN
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Publication number: 20170166517Abstract: This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.Type: ApplicationFiled: February 14, 2017Publication date: June 15, 2017Applicant: Novartis AGInventors: Fabrice GALLOU, Joerg Matthias SEDELMEIER, Caspar VOGEL
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Publication number: 20170166518Abstract: The present invention provides a method for increasing the capacity of a urea production complex, the method comprising a step of adding to an existing urea production complex a CO2 production unit, which unit employs a CO2 production method comprising: i) subjecting a hydrocarbon feed to short contact time catalytic partial oxidation (SCT-CPO) to produce a first gas mixture comprising H2, CO and CO2, ii) subjecting said first gas mixture to a water gas shift reaction yielding a second gas mixture, iii) separating CO2 from said second gas mixture yielding a purified CO2 stream and a hydrogen containing stream and subsequently iv) reacting said purified CO2 stream with ammonia from the ammonia production unit to produce urea. The invention also provides a urea production complex realized by the application of this method and a urea production method.Type: ApplicationFiled: April 21, 2015Publication date: June 15, 2017Applicant: STAMICARBON B.V. ACTING UNDER THE NAME OF MT INNOVATION CENTERInventors: Gaetano IAQUANIELLO, Joey DOBREE
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Publication number: 20170166519Abstract: The invention relates to a DDX3X inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R1, X, L, Ra and Rb are as defined herein. The invention also relates to compounds of Formula (I).Type: ApplicationFiled: March 12, 2015Publication date: June 15, 2017Inventors: Andrew EASTON, Phillip GOULD, Andrew MARSH
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Publication number: 20170166520Abstract: The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3?-dithiodipropionic acid (DPDPA) and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.Type: ApplicationFiled: June 16, 2016Publication date: June 15, 2017Inventors: Hsien-Yeh Chen, Zhen-Yu Guan, Chih-Yu Wu
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Publication number: 20170166521Abstract: The present invention provides a process for producing a perfluoropolyoxyalkylene peroxide compound comprising a step of reacting a perfluoroalkene with oxygen, wherein the reaction of the perfluoroalkene with oxygen is performed under ultraviolet irradiation and in the presence of a fluorine source.Type: ApplicationFiled: December 8, 2016Publication date: June 15, 2017Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Keiichirou WATANABE, Hideki NAKAYA, Motohisa SHINO, Tatsuya TAKAKUWA, Kazunori MORIMOTO
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Publication number: 20170166522Abstract: The present invention provides a process for producing a perfluoropolyoxyalkylene peroxide compound comprising a step of reacting a perfluoroalkene with oxygen, wherein the reaction of the perfluoroalkene with oxygen is performed in a microreactor.Type: ApplicationFiled: December 8, 2016Publication date: June 15, 2017Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Keiichirou WATANABE, Hideki NAKAYA, Motohisa SHINO, Tatsuya TAKAKUWA, Kazunori MORIMOTO
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Publication number: 20170166523Abstract: Disclosed are compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.Type: ApplicationFiled: February 5, 2015Publication date: June 15, 2017Inventors: Naing Aay, Neel Kumar Anand, Charles M. Blazey, Owen Joseph Bowles, Joerg Bussenius, Simona Costanzo, Jeffry Kimo Curtis, Steven Charles DeFina, Larisa Dubenko, Anagha Abhijit Joshi, Abigail R. Kennedy, Angie Inyoung Kim, Elena S. Koltun, Jean-Claire Limun Manalo, Csaba J. Peto, Kenneth D. Rice, Tsze H. Tsang
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Publication number: 20170166524Abstract: The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.Type: ApplicationFiled: February 16, 2017Publication date: June 15, 2017Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Muneaki KURIMURA, Shinichi TAIRA, Takahiro TOMOYASU, Nobuaki ITO, Kuninori TAI, Noriaki TAKEMURA, Takayuki MATSUZAKI, Yasuhiro MENJO, Shin MIYAMURA, Yohji SAKURAI, Akihito WATANABE, Yasuyo SAKATA, Takumi MASUMOTO, Kohei AKAZAWA, Haruhiko SUGINO, Naoki AMADA, Satoshi OHASHI, Tomoichi SHINOHARA, Hirofumi SASAKI, Chisako MORITA, Junko YAMASHITA, Satoko NAKAJIMA
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Publication number: 20170166525Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.Type: ApplicationFiled: August 19, 2016Publication date: June 15, 2017Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
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Publication number: 20170166526Abstract: This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: ApplicationFiled: October 21, 2016Publication date: June 15, 2017Inventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Jayaprakash Pagadala, Charles B. Duke, Christopher C. Coss, James T. Dalton, Yali He
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Publication number: 20170166527Abstract: The present specification provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ROR? and/or ROR?t mediated disease state.Type: ApplicationFiled: December 14, 2016Publication date: June 15, 2017Applicant: AstraZeneca ABInventors: Frank NARJES, Roine Ingemar OLSSON, Stefan VON BERG, Sarah LEVER
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Publication number: 20170166528Abstract: High heat monomer compounds, methods for preparing compounds, and compositions derived from the compounds are provided. Also provided are materials and articles derived from the compounds.Type: ApplicationFiled: July 22, 2015Publication date: June 15, 2017Inventors: Edward Norman PETERS, Prakash SISTA
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Publication number: 20170166529Abstract: A 3-(alkylsulfonyl)pyridine-2-carboxylic acid or a salt thereof can be manufactured by comprising: a step of allowing a compound represented by formula (1-N): (wherein X represents a halogen atom) to react with a compound represented by formula (2): R2SM2??(2) (wherein R2 represents a C1-8 straight-chain alkyl group, and M2 represents a hydrogen atom or an alkali metal) to give a compound represented by formula (3-N): (wherein R2 and X are as defined above); a step of allowing the compound represented by formula (3-N) to react with hydrogen peroxide in the presence of a tungsten catalyst and an acid to give a compound represented by formula (6-N): (wherein R2 and X are as defined above); a step of reducing the compound represented by formula (6-N) in the presence of a base and a heterogeneous transition metal catalyst to give a compound represented by formula (8-N): (wherein R2 is as defined above); and a step of hydrolyzing the compound represented by formula (8-N) in the presenType: ApplicationFiled: June 22, 2015Publication date: June 15, 2017Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Takahiro KIMURA, Ryota MAEHATA
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Publication number: 20170166530Abstract: The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.Type: ApplicationFiled: December 20, 2016Publication date: June 15, 2017Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Ravi K. Amaravadi, Jeffrey Winkler
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Publication number: 20170166531Abstract: The invention features 2-alkoxy-11-hydroxyaporphine derivatives that selectively bind D2high receptors. The compounds are useful for imaging D2high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.Type: ApplicationFiled: November 9, 2016Publication date: June 15, 2017Inventors: John L. NEUMEYER, Yu-Gui SI, Anna Waclawa SROMEK
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Publication number: 20170166532Abstract: A method for producing (R)-1,1,3-trimethyl-4-aminoindane includes the following steps (A), (B), and (C). Step (A) is a step of optically resolving 1,1,3-trimethyl-4-aminoindane to obtain (R)-1,1,3-trimethyl-4-aminoindane and (S)-1,1,3-trimethyl-4-aminoindane, step (B) is a step of racemizing the (S)-1,1,3-trimethyl-4-aminoindane obtained in the step (A) or (C) to obtain 1,1,3-trimethyl-4-aminoindane, and step (C) is a step of optically resolving the 1,1,3-trimethyl-4-aminoindane obtained in the step (B) to obtain (R)-1,1,3-trimethyl-4-aminoindane and (S)-1,1,3-trimethyl-4-aminoindane.Type: ApplicationFiled: December 26, 2014Publication date: June 15, 2017Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tadafumi MATSUNAGA, Natsuru HIRAGURI, Tomoaki TAKAHASHI, Tomohiko INUI, Masaya TANIMOTO
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Publication number: 20170166533Abstract: The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like.Type: ApplicationFiled: August 22, 2016Publication date: June 15, 2017Inventors: Bradley Teegarden, Dennis Chapman, Marc Decaire, Peter I. Dosa, Konrad Feichtinger, Honnappa Jayakumar, Thuy-Anh Tran, Sonja Strah-Pleynet, Jingdong Xu
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Publication number: 20170166534Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicants: Hoffmann-La Roche Inc., EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH, UNIVERSITÄT ZÜRICHInventors: Simon M. Ametamey, Juergen Fingerle, Luca Gobbi, Uwe Grether, Ahmed Haider, Thomas Hartung, Linjing Mu, Leo Nicholls, Mark Rogers-Evans, Christoph Ullmer
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Publication number: 20170166535Abstract: The present invention relates to herbicidal benzyloxy-substituted phenyl-diones and benzyloxy substituted phenyl-dioxo-thiazinone derivatives of formula (I) as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants.Type: ApplicationFiled: July 10, 2015Publication date: June 15, 2017Applicant: Syngenta Participations AGInventors: Stephen Edward SHANAHAN, Paul Matthew BURTON, Benjamin Andrew EGAN, Timothy Jeremiah Cornelius O'RIORDAN
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Publication number: 20170166536Abstract: A reactor and associated process for the high-pressure synthesis of melamine from urea, comprising a primary step of conversion of the urea into crude melamine inside a first chamber delimited by a shell inside a reactor body and a secondary step of stripping said crude melamine melt inside a second reaction chamber, which is coaxial with and situated outside said first chamber, inside the same reactor body.Type: ApplicationFiled: January 30, 2015Publication date: June 15, 2017Applicant: Casale SAInventor: Enrico Rizzi
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Publication number: 20170166537Abstract: The invention provides novel methods of synthesizing new monofunctional and/or multifunctional heterocyclic monomers and the formulation of new alloys of said monomers from base reactants via a continuous solvent-free, or alternatively in-solvent, one-step high shear reactor methodology designed to reduce the minor isomer formation and to eliminate the need for post-processing purification, as well as the ability to disperse reinforcements and additives while synthesizing such heterocyclic monomers and monomer alloys created and to the synthesis of related compositions.Type: ApplicationFiled: December 1, 2016Publication date: June 15, 2017Inventors: Andrew S. Frazee, Jeffrey S. Wiggins
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Publication number: 20170166538Abstract: Compounds of the formula wherein R1 and R2 are independently H, F or CH3 ; or R1 forms an ethynyl bond and R2 is H or C3-C8 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF3, OMe or halo; R3 is C1-C3 alkyl or C3-C8 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R3 is C3-C6 cycloalkyl it may alternatively be gem subsituted with fluoro; R4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A1 is CH or N, A2 is CR6R7 or NR8, provided at least one of A1 and A2 comprises N; R6 is H, C-C4 alkyl, C1-C4 haloalkyl, C1-C3 alkyl-O—C1-C3 alkyl, or when A2 is C, R6 can also be C1-C4 alkoxy or F; R7 is H, C1-C4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporoType: ApplicationFiled: August 25, 2016Publication date: June 15, 2017Inventors: Lourdes Salvador ODEN, Magnus NILSSON, PIA KAHNBERG, Bertil SAMUELSSON, Urszula GRABOWSKA
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Publication number: 20170166539Abstract: The invention provides compounds of formula (I) wherein X is O or S; R1 is H, OH, SH, nitro, NH2, NHC1-6alkyl, N(C1-6alkyl)2, halo, haloC1-6alkyl, CN, C1-6-alkyl, OC1-6alkyl, C1-6alkylCOOH, C1-6alkylCOOC1-6alkyl, C2-6-alkenyl, C3-10cycloalkyl, C6-10aryl, C1-6alkylC6-10aryl, heterocyclyl, heteroaryl, CONH2, CONHC1-6alkyl, CON(C1-6alkyl)2, OCOC1-6alkyl, or is an acidic group, such as a group comprising a carboxyl, phosphate, phosphinate, sulfate, sulfonate, or tetrazolyl group; R2 is as defined for R1 or R1 and R2 taken together can form a 6-membered aromatic ring optionally substituted by up to 4 groups R5; R3 is H, halo (preferably fluoro), or CHal3 (preferably CF3); each R5 is defined as for R1; V1 is a covalent bond or a C1-20alkyl group, or C2-20-mono or multiply unsaturated alkenyl group; said alkyl or alkenyl groups being optionally interupted by one or more heteroatoms selected from O, NH, N(C1-6 alkyl), S, SO, or SO2; M1 is absent or is a C5-10 cyclic group or a C5-15 aromatic group; and R4 is H,Type: ApplicationFiled: February 24, 2017Publication date: June 15, 2017Inventors: George Kokotos, Berit Johansen, Victoria Magrioti, Michael Tsakos
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Publication number: 20170166540Abstract: The present invention relates to a process for the preparation of oxirane compounds of formula II from keto compounds III using dimethyl sulfide (CH3)2S and dimethylsulfate (CH3)2SO4, forming the reagent IV, trimethylsulfonium methylsulfate [(CH3)3S+CH3SO4?], in aqueous solution in the presence of potassium hydroxide (KOH).Type: ApplicationFiled: June 26, 2015Publication date: June 15, 2017Applicant: BASF Agro B.V.Inventors: Joachim GEBHARDT, Manfred EHRESMANN, Tiziana CHIODO, Martin VIERTELHAUS, Roland GOETZ
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Publication number: 20170166541Abstract: Compounds and compositions comprising compounds useful in the treatment of cancer are described herein.Type: ApplicationFiled: December 13, 2016Publication date: June 15, 2017Inventors: Jeffrey O. Saunders, Francesco G. Salituro
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Publication number: 20170166542Abstract: A one pot single step process is described for the synthesis of a compound, including a labeled compound, containing a sulfonyl functional group comprising the step of mixing together a silane, an SO2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. A process for producing tracers from a labeled sulfonyl containing compound prepared by the described process is also included.Type: ApplicationFiled: December 8, 2016Publication date: June 15, 2017Applicant: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Niklas von Wolff, Joëlle Char, Thibault Cantat
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Publication number: 20170166543Abstract: In alternative embodiments the invention provides methods for synthesizing AB-007 (also called loxistatin, E64d, EST or ((2S,3S)-trans-epoxysuccinyl-L-leucyl-amido-3-methylbutane ethyl ester) and its acid form E64c (loxistatin acid), and various synthetic intermediates, and deuterated forms of these compounds, and stereoisomers thereof. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof. A synthetic scheme of the invention provides kilogram quantities of AB-007 manufactured according to current good manufacturing practices (cGMP's), consistent with US FDA requirements for human use. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof.Type: ApplicationFiled: February 2, 2015Publication date: June 15, 2017Inventors: Robert J. Ternansky, Hui Liu, Emerich Eisenreich, Kenneth A. Haines, Daniel Levin, Xuejun Liu
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Publication number: 20170166544Abstract: A process for manufacturing epoxy monomers and/or epoxides in high yields and useful quality and chemical stability by dehydrochlorination of the corresponding chlorohydrins with an alkaline agent, producing the corresponding side product dry salt in a high purity, characterized in that the process comprises the following steps: a. Reaction of the chlorohydrins with the alkaline agent to form corresponding epoxides and the corresponding precipitated chloride salt; b. Dehydration, and optionally completing the reaction, of the reaction mixture of step (a), by use of an azeotropic agent, added to step (b) or generated in situ in step (a), resulting in the producing of a dehydrated reaction mixture; c. Separating the resulting chloride salt by filtration from the dehydrated reaction mixture (b) and d. Isolating the epoxide from the filtered liquid fraction.Type: ApplicationFiled: February 8, 2017Publication date: June 15, 2017Inventors: Pavel KUBICEK, Bedrich NEMECEK, Petr SLADEK
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Publication number: 20170166545Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.Type: ApplicationFiled: May 19, 2015Publication date: June 15, 2017Applicant: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
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Publication number: 20170166546Abstract: A new crystalline form of spirodiclofen of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and using the crystal to prepare stable agrochemical formulation. The invention also describes the use of various solvents towards the crystalline form preparation conditions.Type: ApplicationFiled: December 14, 2015Publication date: June 15, 2017Applicant: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITEDInventor: James Timothy BRISTOW
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Publication number: 20170166547Abstract: Dapagliflozin compounds and process for dapagliflozin preparation are described. Pharmaceutical compositions comprising dapagliflozin or solvates of dapagliflozin, for the treatment of diabetes are also described.Type: ApplicationFiled: October 19, 2016Publication date: June 15, 2017Applicant: CADILA HEALTHCARE LIMITEDInventors: Sanjay Jagdish DESAI, Jayprakash Ajitsingh PARIHAR, Mahesh Laljibhai RUPAPARA