Abstract: A method and system for infusing medical liquid with gasses, the system comprising a gas source, a vacuum pump, a temperature-controlled container including a fluid reservoir coupled to the gas source and the vacuum pump, a heating and cooling system, and a sonicator, and a controller configured to de-gas a liquid in the fluid reservoir by activating the vacuum pump, re-gas the liquid in the fluid reservoir by releasing gas from the gas source to the fluid reservoir via a first fluid line, and deliver the re-gassed liquid from the fluid reservoir to a catheter via a second fluid line.

Abstract: The present specification discloses a portable dialysis system comprising a mechanism that allows the user to accurately position an air bubble in a venous line, so that it can be safely removed. When an air bubble is detected, the system automatically runs the blood pump in a direction such that the air bubble is placed close to the extraction point on the venous line, from where it can safely be removed using a needleless syringe.

Abstract: A blood purification apparatus that is capable of performing a liquid spill prevention operation and uniformizing the amount of air introduced through an opened portion. The blood purification apparatus includes a dialysate introduction line that allows dialysate to be introduced into a dialyzer; a dialysate discharge line that allows the dialysate to be discharged from the dialyzer; coupling tools that allow free switching between a connected state which causes a closed circuit, and an opened state which causes the closed circuit to be opened to form an opened portion; and a control means that performs a liquid spill prevention operation in which external air is introduced through the opened portion. An air detection means, by which air introduced through the opened portion is detectable, is provided in the vicinity of the coupling tools, and the control means stops the liquid spill prevention operation when air is detected by the air detection means.

Abstract: The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system.

Abstract: A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient.

Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.

Abstract: Renal failure therapy system includes a blood filter, a blood pump, a dialysis fluid pump, a blood line connecting to a patient, a transmitter for receiving a transmit signal and transmitting a wave into blood flowing through the blood line, a receiver for receiving the wave and emitting a corresponding received signal, and a processor for initiating the transmit signal and for receiving the received signal, configured to convert the transmit and received signals into a frequency domain, extract spectral values for the converted transmit and received signals, calculate at least one of a reflection coefficient (R) or an impedance ratio (I) using the spectral values, and analyze an imaginary part of at least one of R or I to determine if an access disconnection event concerning fluid communication between the blood line and the patient has occurred.

Abstract: A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the patient. The agent can, for example, be immobilized via covalent bonding or ionic bonding to the at least one surface. The fluid can, for example, be blood or a blood fraction. The agent can, for example, be an agonist, an antagonist or an inverse agonist.

Abstract: A centrifugal separating assembly for separating a fluid biological product into discrete components by centrifugation is disclosed. The assembly includes a first container defining a first cavity adapted to receive a human biological product, the first container having a circular upper wall, a cylindrical sidewall, and a concave shaped bottom wall. The assembly further includes a second container defining a second cavity adapted to receive discrete components, the second container having a convex shaped upper wall, a second cylindrical wall, and a circular bottom wall; and a tubular conduit providing fluid communication between the first cavity and the second cavity.

Abstract: Methods for clearing of fecal matter the wall of a colon or other body lumen for diagnostic inspection, the methods being adapted to clearing of fecal matter comprised of particles of various sizes and compositions. Methods are further adapted for application in patients who have undergone a restricted scope of preparation to reduce and/or remediate the particle structure of colon contents, or no preparation at all, before diagnostic inspection.

Abstract: An uterotubal irrigation system and process for implanting hysterosalpingogram (HSG) procedures is provided. The uterotubal irrigation system serially irrigates and evacuates fluid in the uterus and into the Fallopian tubes, for the collection of cells from the Fallopian tubes. The uterotubal irrigation system has a partially flexible cannula for introduction through the cervical os into the uterine cavity. The cannula has an enlarged external plug proximal to the distal tip of the cannula, to occlude the os and permit infusion of fluid into the uterus. The cannula has an internal tube for irrigation, and an external sheath with multiple slits near the distal end of the cannula. An uterotubal irrigation system is provided that includes a catheter with two opposing outlet openings on a distal tip of the catheter that injects an irrigation fluid in two opposing jets that splay out laterally toward the openings of a patient's Fallopian tubes.

Abstract: Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

Abstract: A system of intravenous fluid temperature control is a combination of apparatuses that provides a two-stage temperature control of intravenous (IV) fluid. The combination of apparatuses includes an IV fluid retention unit, a microcontroller, at least one heating mechanism, a temperature sensor, and a portable power source. The IV fluid retention unit contains the IV fluid which is delivered into a patient. The at least one heating mechanism and the temperature sensor is in thermal communication with the IV fluid retention unit. The microcontroller is electronically connected to the at least one heating mechanism and the temperature sensor. The microcontroller, the at least one heating mechanism, the temperature sensor, and the portable power source is externally mounted on the IV fluid retention unit. The portable power source is electrically connected to the microcontroller, the at least one heating mechanism, and the temperature sensor.

Abstract: This disclosure relates to the technical field of medical devices. Some embodiments provide an infusion system and a method for controlling a liquid flow rate of the infusion system, which can automatically adjusting the infusion flow rate according to the current physical condition of a patient. The infusion system comprises an infusion device and a monitoring device. The infusion device comprises an infusion tube for receiving liquid medicine from a liquid medicine container, and the infusion tube may be provided with an infusion flow rate regulating device for regulating the flow rate of the liquid medicine. The monitoring device may be configured for monitoring physiological parameters of the patient, and may control the infusion flow rate regulating device to regulate the flow rate of the liquid medicine according at least to the physiological parameter information of the patient.

Abstract: Systems and methods for automatically delivering medication to a user. A sensor coupled to a user can collect information regarding the user. A controller can use the collected information to determine an amount of medication to provide the user. The controller can instruct a drug delivery device to dispense the medication to the user. The drug delivery device can be a wearable insulin pump that is directly coupled to the user. The controller can be part of or implemented in a cellphone. A user can be required to provide a confirmation input to allow a determined amount of insulin to be provided to the user based on detected glucose levels of the user. The sensor, controller, and drug delivery device can communicate wirelessly.

Abstract: There is disclosed a medical system comprising one or more sensors associated with one or more actuators. Various embodiments describe sensors and/or actuators, logic circuits, user interfaces, association schemes, communication schemes, security schemes, cryptographic schemes, medical management rules, social mechanisms, energy management schemes, time and/or space schemes, body analytes and/or biomarkers, blood glucose and/or interstitial glucose sensors, drug delivery devices, continuous glucose monitoring devices, as well as flash glucose monitoring devices. Methods, software and other hardware aspects are described.

Abstract: An injector assembly comprises a collapsible container for containing a liquid medicament (15); and pressurising means (21, 101) arranged to apply a first force to the collapsible container to continuously pressurise the liquid medicament 15 during storage of the liquid medicament 15. The pressurising means (21, 101) is actuatable to apply a second force, which is greater than the first force, to the collapsible container.

Abstract: The present invention relates to a medicament delivery device comprising a housing, which housing is arranged to accommodate a medicament container, which medicament container comprises a medicament delivery member; a power unit interactively connected to the housing comprises a force element and a plunger rod which is arranged to, upon activation, move linearly in the proximal direction and act on said medicament container for expelling a dose of medicament through said medicament delivery member; and a holding member connected to said power unit and to said container holder. The invention is characterised in that the plunger rod comprises at least one first guide-and-stop element configured to interact with at least one second guide-and-stop element on said a holding member for limiting the linear distance the plunger rod is capable of moving during expelling of medicament and which distance corresponds to a dose volume.

Abstract: A cartridge for containing and dispensing a medicament, the cartridge including a cartridge body having an interior cavity therein, a stopper movably disposed within the interior cavity, and a septum disposed at an opposite end of the interior cavity from the stopper, for containing the medicament within the interior cavity. The cartridge also includes a connection thread integrally formed as a unitary construction of the cartridge body, the thread being disposed at a first end of the cartridge body for connecting a pen needle directly to the cartridge body to pierce the septum and provide communication between the medicament and a patient end of the pen needle.

Abstract: A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

Abstract: A pre-filled syringe having containing therein at least one therapeutic is provided. The syringe contains a silicone free barrel and an elastomeric syringe stopper that is covered with an expanded polytetrafluoroethylene barrier layer. The presence of a barrier layer that is at least partially porous on the outside of the syringe stopper improves the seal between the stopper and syringe barrel and minimizes the sliding force. In some embodiments, the barrel is formed of a glass material such as a borosilicate glass, that is free of silicone or other lubricants.

Abstract: The present invention provides a medical device (200) comprising a housing (201, 202), a guide structure (205) arranged stationarily with respect to the housing (201, 202) and ex-tending along a longitudinal axis, the guide structure (205) comprising a helical track (287) and a longitudinal track (289) being connected with the helical track (287) at a transition point (288), and a nut assembly (220) adapted to move along the guide structure (205).

Abstract: An autoinjector has a main body (10, 12) containing a syringe (13) or cartridge with a needle at its front end for being moved forwardly in the body to extend the needle from the body for an injection, the body housing in a forward region a shroud (24) having a forward portion of generally tubular form (32), the shroud being moveable longitudinally between a rearward retracted position and a forward extended position, the autoinjector further including a spring arrangement for biasing the shroud forwardly, the spring arrangement (44) including two springs disposed alongside and spaced from the longitudinal axis.

Abstract: Self-injection tool includes a base and a shroud member. The base includes a proximal end, a distal end, and a barrel engagement portion. The barrel engagement portion defines a cavity to receive at least a portion a syringe barrel such that the distal end of a needle extends a first distance from the distal end of the base. The shroud member includes a proximal end and a distal end. The proximal end is movably coupled to the base. The shroud member is movable between a fully-extended position and a fully-retracted position. In the fully-extended position the shroud member is an extended distance from the distal end of the base. In the fully-retracted position the shroud member is a retracted distance from the distal end of the base. The extended distance is greater or equal to the first distance; the retracted distance is less than the first distance.

Abstract: An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

Abstract: An apparatus and method of automatically and safely removing a needle from a syringe assembly while retaining a syringe hub as part of the syringe assembly is generally described. A needle containment device is provided, which may include a needle handling apparatus and a shutter mechanism assembly. The needle handling apparatus is configured for receiving at least a portion of a syringe assembly including at least a needle and a syringe hub, wherein a first clamping mechanism is configured to clamp the syringe hub and a second clamping mechanism is configured to clamp the needle, and the needle is safely and automatically removed from the syringe hub.

Abstract: The present disclosure provides medical devices, particularly medical grade needles with removable tips, as well as methods of needle tip installation and removal, and devices therefor. Needle tip installation and removal devices may include needle tip installation and removal tools and kits, including hand held and manipulated tools that facilitate the installation and removal of needle tips, particularly on vascular access port needles. Such installation and removal devices may provide more expedient hook up of the access port for the therapy. Also, the installation and removal of the needle tips may be conducted in a more sterile manner.

Abstract: A portable, personal, reusable, cryotherapy unit in the form of a pre-injection site dermal numbing and marking unit includes an insulating sealable freezable rigid container, generally a plastic cylindrical structure, a freezable fluid or gel within the rigid container, and a high heat transferring applicator end having a curved application surface. A method pre-injection site treatment and periodic post injection site treatment is disclosed.

Abstract: The present invention relates to devices, systems and methods for spectrally identifying tissues and guiding the introduction of a probe, needle, and medical instrument into a body structure. The probe can further be used for precise delivery of therapeutic agents to selected regions of the body.

Abstract: A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible nebulization catheter that can be manipulated during use, a device for the introduction of the nebulization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller. The system may include a liquid source having a mixture of hyaluronic acid and heparin that, in conjunction with the nebulizing catheter, are designed to generate an aerosol with a particle size of 10-25 microns in a body cavity. The method includes providing an aerosol of anti-adhesive medication to an organ or body cavity while controlling overall pressure in the organ or cavity.

Abstract: Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.

Abstract: The invention relates to an inhaler component for forming a vapor/air mixture or/and condensation aerosol by evaporation of a liquid material and, if appropriate, condensation of the formed vapor, comprising: an electric heating element for evaporating a portion of the liquid material; a wick with a capillary structure, which wick forms a composite with the heating element and automatically supplies the heating element with the liquid material; a carrier plate, preferably a printed circuit board, which carries the composite and on which the heating element is electrically contacted; a capillary gap formed at least partially by the carrier plate and automatically supplying the composite with the liquid material, by means of an end portion of the wick extending into the capillary gap; a liquid container which contains the liquid material and from which the capillary gap draws the liquid material.

Abstract: Some embodiments are directed to a compliance monitor for monitoring usage of a medicament delivery device that includes a store of medicament, and a medicament dispenser for delivering a dose of medicament. The compliance monitor includes a compliance monitor housing configured to attach to the medicament delivery device, a dose detector for determining when a dose of medicament is dispensed, and a recognition module for identifying the properties of the medicament delivery device.

Abstract: The present disclosure relates to a dose indicator comprising, a chassis comprising a 42 chassis frame and a displacement portion, an indexable first display unit, mountable on the chassis, the first display unit being indexable about a first display axis, the indexable first display unit comprising a plurality of indexing teeth, a first display non-return arm, and a drive pawl connected at its proximal part to the displacement portion, the drive pawl comprising a socket at its distal part, the socket being adapted to engage an indexing tooth of the first display unit during indexing. The disclosure further relates to an actuator for an inhaler, wherein the actuator comprises a dose indicator as described above. The present disclosure is also directed to an inhaler comprising such actuator.

Abstract: A nasal mask has a flexible bottom edge portion and side portions. A delivery device includes a holding chamber coupled to the nasal mask. A method of delivering an inhalable substance includes positioning a nose of a user in a cavity of the nasal mask, inhaling through the nose, and orally soothing the user with a soothing device.

Abstract: A positive exhalation pressure device (1) is described. The device (1) comprises a housing (2) having an annular chamber (5), a chamber inlet (6) configured to permit air into the chamber, a chamber outlet (7) configured to permit air out of the chamber, and a mouthpiece (8) in fluid communication with the chamber inlet. A movable body such as a ball (3) is disposed in the housing within the annular chamber and configured to revolve around the annular chamber in response to flow of air through the chamber from the chamber inlet to the chamber outlet. The movable body is configured to at least partially block the chamber outlet as it revolves around the annular chamber causing cyclical fluctuations in airflow resistance.

Abstract: An intelligent bionic expectoration system and a three-way device thereof. The intelligent bionic expectoration system includes a negative pressure suction module, a central processing module, a patient interface unit and a respiratory muscle synchronous motion module. The central processing module controls two valves to open or close, closing one valve while opening another valve, and controls the respiratory muscle synchronous motion module. The patient interface unit is connected to the positive pressure ventilation module and the negative pressure suction module, allowing positive or negative pressure airflow to flow by, depending on which valve is open, so as to allow airflow to flow in or out of the lung. The respiratory muscle synchronous motion module can employ nerve stimulation and mechanical pushing, and acts synchronously as the airflow moves, thereby simulating human coughing and achieves bionic expectoration.

Abstract: In certain example embodiments, a system and/or method of guiding transitions between therapy modes in connection with the treatment and/or diagnosis of a patient for a respiratory disorder is/are provided. Respiratory disorder treatment according to a first therapy mode is provided. Input indicating a second therapy mode to be transitioned to following provision of the first therapy mode is received, with the second therapy mode being different from the first therapy mode. At least one default treatment parameter suitable for the second therapy mode is assigned or calculated. Each default treatment parameter of the second therapy mode is presented, with each default treatment parameter being adjustable by an operator during the presenting. Transitioning from the first therapy mode to the second therapy mode is performed by providing respiratory disorder treatment in accordance with the second therapy mode and each default treatment parameter and any adjustments made thereto prior to the transitioning.

Abstract: Provided herein are fire safety face masks and systems comprising the same for displacing excessive oxygen away from a surgical area. The face mask comprises a body portion, an exhalation conduit fluidly connected to the body portion and an in-flow tubing in a fluidly connecting relationship with the body portion. The fire safety face mask may further comprise a gas sampling port disposed on the body portion to facilitate monitoring of inspired and exhaled gases via a multi-gas analyzer. Also provided are methods for preventing fires in an operating theater during a surgical procedure utilizing the fire safety masks and systems disclosed herein.

Abstract: An inner cannula (20) for a tracheostomy tube assembly includes a thin, inner sheath (22) supported externally by a structural frame (23) having a longitudinal portion (25) and a plurality of ribs (26) extending circumferentially and spaced along the cannula. The inner cannula (20) is inserted within and is removable from an outer tracheostomy tube (1). The inner cannula (20) is made by coating a plastic layer on a core to form the sheath and then placing the sheath on a curved core. The structural frame (23) is then moulded about the sheath (22) in a mould 80.

Abstract: The present disclosure provides a device that can be used to secure an endotracheal tube. In one embodiment, the device is a one-time use device that has a flexible construction with an adhesive side. The device is configured to be adhered to the endotracheal tube and subsequently secure unto the patient's face. The device is quick and easy to deploy, it reliably secure the endotracheal tube, is comfortable for the patient, and that minimized the chances of infection.

Abstract: A patient tube securement apparatus is disclosed that may be used for oral or nasal intubation of a patient. The apparatus may comprise an endotracheal tube securement apparatus for securing an endotracheal tube to a patient, the apparatus comprising a dermal patch arranged to be positioned on the skin of the patient, and at least one tube holder on the dermal patch. The apparatus may comprise a patient tube securement apparatus for securing a patient tube to a patient, the apparatus comprising a dermal patch arranged to be positioned on the skin of the patient, and at least one tube holder on the dermal patch. Examples are provided in which the tube holder is adjustably mounted on the dermal patch such that the position of the tube holder on the dermal patch can be adjusted without removing the dermal patch from the skin of the patient.

Abstract: Systems and methods permit generation of a digital scan of a user's face such as for obtaining of a patient respiratory mask, or component(s) thereof, based on the digital scan. The method may include: receiving video data comprising a plurality of video frames of the user's face taken from a plurality of angles relative to the user's face, generating a three-dimensional representation of a surface of the user's face based on the plurality of video frames, receiving scale estimation data associated with the received video data, the scale estimation data indicative of a relative size of the user's face, and scaling the digital three-dimensional representation of the user's face based on the scale estimation data. In some aspects, the scale estimation data may be derived from motion information collected by the same device that collects the scan of the user's face.

Abstract: A gas ventilation mask includes an anesthesia nasal mask and a mouth mask defining respectively a nasal chamber and an oral chamber, detachably connected to one another so that the nasal mask and the mouth mask may be used either separately as a nasal mask or as a mouth mask, or as a combination nasal-mouth mask. Also provided is a mask anchor for holding a face mask on a patient, includes a head support for engaging a back of a patient's head, a posterior head strap that originates from behind the patient's head, in contact with the patient's head and attaches either directly or indirectly to the mask when the mask is on the patient's face, wherein the strap can be tightened to create a seal to allow for positive pressure ventilation or left loose and for providing supplement oxygen.

Abstract: Disclosed is a nasal ventilation mask having separate ports to monitor end-tidal CO2 expulsion integrated into the mask in order to monitor end-tidal CO2 expelled nasally or orally. Also disclosed is a CPR mask for nose-to-mouth and/or mouth-to-mouth resuscitation, having a body shaped to cover the nose and/or mouth of a victim, said mask including a CO2 absorber for eliminating at least in part rescuer's exhaled CO2 delivered to the victim.

Abstract: A patient interface assembly having an improved support for use in securing a patient interface device to the head of a patient overcomes the shortcomings of conventional headgear. The improved support provides a self-adjusting anchor point situated anterior to the ear of the patient that provides enhanced stability in mounting the patient interface device to the patient.

Abstract: A system provides warm, humidified gas to a patient via a patient interface. Horizontal connections can be used between the humidification chamber and conduit. To reduce the likelihood of condensate flowing back to the humidification chamber, or dead space or gases recirculation regions occurring within the gases flow path, a raised portion is positioned inside of the flow path to improve flow characteristics and to provide a barrier for condensate back flow. The raised portion also reduces the amount of condensate that is formed in the system and provides better flow characteristics for sensing purposes.

Abstract: The present invention provides an inhalation device for controlled delivery of medicament to the lungs of the user. The inhalation device comprises an elongated housing enclosing a mouthpiece/nasal-piece in fluid communication to a narrow cylindrical tube, the narrow cylindrical tube having diameter substantially similar to the lumen diameter of human bronchi. The other end of narrow cylindrical tube is fluidly connected to a reservoir containing the medicament suspended or dissolved in the propellant. The flow of propellant from reservoir to the narrow cylindrical tube is regulated by a one-way valve, which could be electrical/electronic or a mechanical valve. The invention is advantageous by providing positive airway pressure to keep the constricted air passages of the user open, which is combined, with laminar flow of medicament suspended/dissolved in the propellant, thus, resulting in efficient deposition of medicament to the target tissues of the lungs.

Abstract: A system for improving a health status of a person by analyzing and applying frequency information at a person is disclosed. The frequency information could be collected from an audio sample, or could be collected via feedback frequencies occurring when a test frequency is applied at the person. The system analyzes the collected frequency information to determine a status of the patient, for example a fundamental frequency of the person and/or a weak frequency of the person. Based upon the frequency information, the system generates a protocol to implement one or more frequencies at the person, for example sonic frequencies, light frequencies, and/or vibrational frequencies. Depending upon which frequencies are implemented, the state of the person can be improved.

Abstract: Disclosed herein are an audio apparatus and method for inducing a brainwave using a binaural beat, including a frequency shift unit for receiving a first audio sound source signal and generating a second audio sound source signal by shifting some of the frequency band of the first audio sound source signal by a specific frequency, and an audio output unit connected to the frequency shift unit, for outputting first and second audio output signals corresponding to the first and the second audio sound source signals. Accordingly, a user can hear a music signal or an audio signal for learning without being aware of the distortion of a sound source and can change his or her brainwave state without resistance or monotonousness because a required brainwave state is changed by applying a binaural beat to a specific frequency band of an audio signal, in particular, a music signal.