Patents Issued in June 27, 2017
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Patent number: 9688933Abstract: The charcoal-foam heating material is formed by combining a charcoal mixture with an aqueous surfactant and water to create a semi-homogenous charcoal-foam slurry. The slurry is poured into shaping molds so that the slurry dries into the charcoal-foam heating material. In the preferred embodiment, a concrete surfactant is used during the mixing process and the charcoal-foam slurry is formed into briquettes and used as a cooking fuel.Type: GrantFiled: September 11, 2009Date of Patent: June 27, 2017Assignee: The United States of America, as represented by The Secretary of AgricultureInventors: Gregory M. Glenn, Syed Hussain Imam, Artur Klamczynski
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Patent number: 9688934Abstract: A method of and device for processing carboneceous material into gas and activated carbon together with blower.Type: GrantFiled: November 5, 2009Date of Patent: June 27, 2017Assignee: BIXBY ENERGY SYSTEMS, INC.Inventor: Sherman Aaron
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Patent number: 9688935Abstract: The inventive technology includes methods and apparatus for the generation and application of segregated catalytic additives for the pre-combustion treatment of carbonaceous fuel and/or feedstocks. The application of such segregated additives results in the reduction of environmentally harmful emissions during combustion as well as gasification processes. Specifically, pre-combustion treatment of carbonaceous materials with the inventive additives results in the reduction of NOx and/or mercury emissions by least 20% and 40% respectively.Type: GrantFiled: January 30, 2015Date of Patent: June 27, 2017Assignee: VRC Technology, LLCInventors: Marcus A. Wiley, Matthew A. Cotton, Darlene K. Sherrod, Marcus K. Wiley, Timothy P. Lenneman, Thomas Kenyon Gale
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Patent number: 9688936Abstract: The present invention relates to a preparation method of a lube base oil including a conversion of biomass fat to a fatty acid; a separation of a C18 unsaturated fatty acid from the fatty acid; a maximization of an oleic acid content through partial hydrotreating of the C18 unsaturated fatty acid; a synthesis of a dimer or higher-order oligomer through an oligomerization of the oleic acid; and an esterification of the oligomer, and relates to a lube base oil prepared therefrom. The lube base oil of the present invention contains an x-type diester dimer and has an excellent low-temperature stability and a high biodegradability resulting from its chemical structure, thus being ecofriendly.Type: GrantFiled: October 7, 2015Date of Patent: June 27, 2017Assignees: SK Innovation Co., Ltd., SK Lubricants Co., Ltd.Inventors: Hee Jung Jeon, Yong Woo Kim
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Patent number: 9688937Abstract: The invention relates to a method for producing a stable boron solution with lubricating characteristics which is intended to be used preferably as an addition in the form of a concentrate/additive to a liquid, e.g. to a liquid fuel or a lubricant. The invention is achieved by the method steps of using a boron substance of pharmaceutical quality (1, 11), using a liquid as solvent, applying a mixing ratio between the boron substance and the solvent (3, 13) of preferably 1 g of boron per 15-25 liters of liquid, agitating the mixture for an initial predetermined period of time (4, 14), adding further liquid to dilute the solution (6, 15), the quantity of liquid being chosen such that a final user mixture reaches a concentration of between 20 and 30 ppm of boron (8), and further agitating the mixture (7, 16) for a second predetermined period of time so that the boron substance is completely dissolved in the boron solution, resulting in a boron solution which is stable over time.Type: GrantFiled: December 3, 2015Date of Patent: June 27, 2017Assignee: Triboron International ABInventors: Tommy Lindblom, Magnus Undén
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Patent number: 9688938Abstract: A lubricant composition including an acyclic amine compound. A method of lubricating a system including a fluoro-polymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The acyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals.Type: GrantFiled: August 14, 2013Date of Patent: June 27, 2017Assignee: BASF SEInventors: Kevin J. Desantis, Michael Hoey, Bjoern Ludolph, Matthias Kiefer
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Patent number: 9688939Abstract: Sulfurized calcium phenate detergents having a reduced unsulfurized alkyl-substituted phenol content are made by: (A) providing, made from an unsulfurized alkyl-substituted phenol, a sulfurized calcium phenate detergent that, optionally, may have been further reacted with carbon dioxide; (B) adding to the detergent from 1 to 100 mass %, based on the mass of the detergent, of an organic solvent that has a boiling point of above 100° C. and below the boiling point of the unsulfurized alkyl-substituted phenol; and (C) removing the organic solvent from the detergent thereby to reduce the unsulfurized alkyl-substituted phenol content.Type: GrantFiled: January 26, 2016Date of Patent: June 27, 2017Inventors: Dirk Schwaebisch, Jamie Musmacher, Alastair A. Cant
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Patent number: 9688940Abstract: [Object] To provide lubricating thermoplastic resin compositions that can give formed articles exhibiting excellent lubricating properties and surface appearance and maintaining the lubricating properties permanently. [Solution] The lubricating thermoplastic resin composition includes an acid-modified copolymer (A) of a monomer mixture including an aromatic vinyl and a vinyl cyanide, the copolymer having a carboxyl group in the molecular chain, and a functionalized lubricant (B) having, in the molecule, a functional group (B1) capable of reacting with the carboxyl group and a lubricating segment (B2) having lubricating properties. The composition may further include a graft copolymer (C) and/or an additional thermoplastic resin (D) other than the acid-modified copolymer (A).Type: GrantFiled: April 5, 2013Date of Patent: June 27, 2017Assignee: UMG ABS, LTD.Inventors: Yoshitaka Naitoh, Kousaku Tao, Tomonori Takase, Risa Nii, Yoshiaki Shinohara, Keiichi Yagi, Nobutaka Hase
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Patent number: 9688941Abstract: Provided is a lubricating oil composition for a shock absorber, which realizes excellent riding comfort in low-temperature and high-temperature environments and can suppress worsening of riding comfort with time, which is caused by evaporation and shearing of the lubricating oil. The lubricating oil composition for a shock absorber contains (A) a base oil having a pour point of lower than ?40° C. and a kinematic viscosity at 80° C. of from 2.0 to 2.7 mm2/s, (B-1) from 1 to 15% by mass of a polymethacrylate having a weight-average molecular weight of from 10,000 to less than 100,000, and (B-2) from 0.1 to 5% by mass of a polymethacrylate having a weight-average molecular weight of from 100,000 to 200,000.Type: GrantFiled: August 25, 2014Date of Patent: June 27, 2017Assignee: IDEMITSU KOSAN CO., LTD.Inventors: Shuichi Sakanoue, Aya Aoki
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Patent number: 9688942Abstract: A method for preparing a final grease product comprising steps of: (a) mixing a polymeric thickener, which comprises a polymer of propylene, and a lubricating base oil at a temperature above the melting point of the polymeric thickener, wherein the polymeric thickener is present in an amount of 11.5-15.5 wt %, based on the total weight of the mixture so obtained; (b) cooling the mixture as obtained in step (a); (c) subjecting the cooled mixture as obtained in step (b) to a first mechanical treatment, to obtain an intermediate grease; (d) subjecting the intermediate grease as obtained in step (c) to a second mechanical treatment, carried out at a temperature in the range of from 50-90° C., to obtain the final grease product. The method can be applied to manufacturing of a grease.Type: GrantFiled: January 8, 2014Date of Patent: June 27, 2017Assignee: AKTIEBOLAGET SKFInventor: Dick Meijer
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Patent number: 9688943Abstract: The disclosure relates to candles, including multi-wick candles, that contain one more non-ionic emulsifiers. The non-ionic emulsifier(s) can be contained in the candle base formulation and/or in the wick coating formulation. The candles exhibit one or more desirable properties, such as good flame height, good fragrance character, low mineral impurity levels and little or no discoloration.Type: GrantFiled: May 29, 2015Date of Patent: June 27, 2017Assignee: beauty Avenues LLCInventors: Raymond Cen, Maureen Stanley, Michael J. Regina, Catherine Arnold
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Patent number: 9688944Abstract: Synergistic surfactant blends are disclosed. In one aspect, the blend comprises an anionic surfactant and a metathesis-based cationic surfactant comprising a quaternized derivative. The quaternized derivative is a quaternized fatty amine, quaternized fatty amidoamine, imidazoline quat, or esteramine quat made from a metathesis-derived C10-C17 monounsaturated acid or its ester derivative. Also disclosed are synergistic surfactant blends comprising a cationic surfactant and a metathesisbased anionic surfactant comprising a sulfonated derivative. The sulfonated derivative is a fatty ester sulfonate, fatty acid sulfonate, sulfoestolide, fatty amide sulfonate, sulfonated fatty ester alkoxylate, imidazoline quat sulfonate, sulfonated amidoamine oxide, or sulfonated amidoamine betaine. The synergistic blends have a negative value or a reduced interfacial tension (IFT) when compared with an expected IFT value calculated from the individual surfactant components.Type: GrantFiled: April 12, 2013Date of Patent: June 27, 2017Assignee: Stepan CompanyInventors: Randal J. Bernhardt, Xue Min Dong
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Patent number: 9688945Abstract: Method for treating a textile under industrial and institutional fabric care conditions to impart softness within a single wash and/or rinse cycle are disclosed. More particularly, the present invention relates to a combination of a liquid or solid fabric conditioning composition and a softening booster for treating a textile to impart softness within a single wash and/or rinse cycle. Compositions employed therein are further disclosed.Type: GrantFiled: November 21, 2014Date of Patent: June 27, 2017Assignee: Ecolab USA Inc.Inventors: Amanda Ruth Blattner, Charles Allen Hodge, Claire Lucille Notermann, Julio R. Panama, Shaun Patrick Kennedy
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Patent number: 9688946Abstract: A cleaning composition comprises at least one surfactant and at least one colorant. The cleaning composition can have a pH of about 3 or less. The colorant exhibits one of several specified structures at a pH of about 7. A method for cleaning a surface utilizes the cleaning composition.Type: GrantFiled: October 23, 2013Date of Patent: June 27, 2017Assignee: Milliken & CompanyInventors: Yogesh Saraf, Eduardo Torres, Sanjeev K. Dey, Paul D. Halphen
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Patent number: 9688947Abstract: A polymeric dispersant comprising: (a) from 50 to 95 wt % polymerized residues of monomer (A): wherein R1 is hydrogen, methyl, ethyl or COOX; R2 is hydrogen, methyl or ethyl; R3 is hydrogen, methyl or ethyl; and X is hydrogen, sodium, potassium, ammonium or a combination thereof; (b) from 1 to 20 wt % polymerized residues of monomer (B): wherein R4, R5, and R6 are independently hydrogen, methyl or ethyl; R7 is C8-C30 alkyl or C8-C30 aralkyl; and (c) from 3 to 30 wt % polymerized residues of monomer (C): wherein R8, R9, and R10 are independently hydrogen, methyl or ethyl; R11 and R12 are independently hydrogen, C1-C8 alkyl or hydroxymethyl; and n is an integer from 1 to 3.Type: GrantFiled: December 4, 2013Date of Patent: June 27, 2017Assignees: Rohm and Haas Company, Dow Global Technologies LLCInventors: Marianne P. Creamer, Jan E. Shulman, Eric P. Wasserman
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Patent number: 9688948Abstract: The present invention provides a coated detergent particle having perpendicular dimensions x, y and z, wherein x is from 0.5 to 2 mm, y is from 2 to 8 mm, and z is from 2 to 8 mm, wherein the particle comprises: (i) from 20 to 39 wt % of a surfactant selected from: anionic and non-ionic surfactants; (ii) from 10 to 40 wt % of an inorganic salt coating selected from: sodium carbonate and/or sodium sulphate of which at least 5 wt % of the inorganic salt is sodium carbonate; and, (iii) from 10 to 40 wt % of calcite having a median particle size average diameter (D50) in the range from 10 to 70 microns, and wherein the inorganic salts are present on the detergent particle as a coating and the surfactant is present in a core with the calcite dispersed through the core.Type: GrantFiled: September 20, 2013Date of Patent: June 27, 2017Assignee: CONOPCO, INC.Inventors: Jonathan Osler, David Christopher Thorley
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Patent number: 9688949Abstract: A beer making system may use a detachable vessel to contain liquid during the mashing and boiling steps, and may also be used during the fermentation steps of beer making. The beer making system may recirculate liquid through the vessel, then select between several flow paths during the beer making process. A removable reservoir system having a grain reservoir and several hops or adjunct reservoirs may be selected as a flow path, as well as a bypass flow path. A programmable controller may cause liquid to recirculate through a heater and one of the various flow paths, the sequence, timing, and temperature profile of which are defined in a recipe for a particular beer.Type: GrantFiled: September 12, 2014Date of Patent: June 27, 2017Assignee: PicoBrew, Inc.Inventors: William H. Mitchell, James B. Mitchell, Avi R. Geiger
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Patent number: 9688950Abstract: A bioreactor for culturing cells in a liquid environment is provided that is designed to reduce the chance of contamination, contain the contamination should it occur, and readily clean and sterilize all or part of the bioreactor in response to contamination, or on a schedule. A processor-controlled method of promoting sterility in a bioreactor is also provided.Type: GrantFiled: June 30, 2013Date of Patent: June 27, 2017Assignee: INDUSTRIAL PLANKTON INC.Inventor: Robert Roulston
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Patent number: 9688951Abstract: The invention includes a bioreactor system for growing a photosynthetic culture in an aqueous liquid and harvesting the photosynthetic culture. The present invention further relates to a method for growing a photosynthetic culture in an aqueous liquid and harvesting the photosynthetic culture. The present invention further relates to a use of a harvester system arranged to collect at least part of the scooped photosynthetic culture in a photo bioreactor system.Type: GrantFiled: July 31, 2009Date of Patent: June 27, 2017Assignee: ALGAE-TECH LTD.Inventors: David Dean Krenbrink, Hendrik Joseph Karel Hoevers
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Patent number: 9688952Abstract: A micro fluid dosing unit includes a test container containing biomaterial needing oxygen. The test container has at least one first container which contains water and at least one second container which contains a pharmacological substance, wherein the first and the second containers have a container outlet leading to the test container and are mounted on a common valve carrier plate containing control channels, which includes control channel ports for control valves to be coupled thereto. In the valve carrier plate a separate valve control chamber is formed for each container, which is sealed by a membrane, wherein associated container outlets are opened and closed by the membrane movement.Type: GrantFiled: July 8, 2014Date of Patent: June 27, 2017Assignee: Buerkert Werke GmbHInventor: Peggy Schaefer
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Patent number: 9688953Abstract: Separating and singulating embryos employs a spray module configured to spray a plurality of embryos which are loaded on a porous substrate so as to separate and singulate the plurality of embryos, and a drying module configured to dry the plurality of separated and singulated embryos retained on the porous substrate while the porous substrate is moved across the drying module. A robotic arm operates to transfer the porous substrate from module to module, and a control device controls the operation of the system of separating and singulating embryos.Type: GrantFiled: March 23, 2015Date of Patent: June 27, 2017Assignee: Weyerhaeuser NR CompanyInventors: Anthony P. Swanda, Henry M. Givens
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Patent number: 9688954Abstract: The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moeities of the gangliosides GM3, GD3, and GT3.Type: GrantFiled: January 29, 2015Date of Patent: June 27, 2017Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventor: Eric Samain
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Patent number: 9688955Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.Type: GrantFiled: November 7, 2014Date of Patent: June 27, 2017Assignee: Nano3D Biosciences, Inc.Inventor: Glauco R. Souza
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Patent number: 9688956Abstract: A method for preserving proliferation and differentiation potential of undifferentiated cells, has steps of providing a culture carrier having a surface coated with a biological material selected from the group consisting of hyaluronan, chondroitin sulfate, carboxymethyl cellulose, carrageenan, alginate, and chitosan; and inoculating and culturing the undifferentiated cells on the surface in the culture carrier with an appropriate medium, such that the proliferation and differentiation potential of undifferentiated cells are preserved. The method can be used for expanding stem cells in vitro without loss of their replicative ability and differentiation capacity. Therefore, the method according to the present invention is amenable to application in regenerative medicine, tissue engineering, and therapy using umbilical cord blood and other cell sources such as peripheral blood, stem cells, tissue progenitor cells, and tissue cells.Type: GrantFiled: July 10, 2015Date of Patent: June 27, 2017Assignee: National Cheng Kung UniversityInventor: Lynn Ling-Huei Huang
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Patent number: 9688957Abstract: Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.Type: GrantFiled: April 10, 2015Date of Patent: June 27, 2017Assignee: Wisconsin Alumni Research FoundationInventors: William L. Murphy, Ngoc Nhi Le, Michael P. Schwartz, Eric Huy Dang Nguyen, Stefan Zorn, Hamisha Ardalani, Matthew Zanotelli, Matthew Brian Parlato, David Gregory Belair, William T. Daly
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Patent number: 9688958Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.Type: GrantFiled: August 23, 2016Date of Patent: June 27, 2017Assignee: FLODESIGN SONICS, INC.Inventors: Thomas J. Kennedy, III, Bart Lipkens, Louis Masi, Stanley Kowalski, Chris Leidel
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Patent number: 9688959Abstract: In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium component. This disclosure also provides a method for preparing the composition, comprising the steps of (a) lysing platelets providing a lysate; (b) removing cell debris; and (c) depleting fibrinogen by forming a removable mass by adding a metal salt such as calcium chloride. Furthermore, the disclosure also describes the product produced using said method.Type: GrantFiled: June 26, 2012Date of Patent: June 27, 2017Assignees: Emory University, Children's Healthcare of Atlanta, Inc.Inventors: Ian B. Copland, Jacques Galipeau
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Patent number: 9688960Abstract: Methods to preserve and/or protect beta cell function by contacting a population or preparation of pancreatic cells, beta cells and/or islets with an inhibitor of NADPH oxidase-1 (NOX-1). Methods of treating a subject for diabetes by administering a therapeutically effective amount of a NOX-1 inhibitor to the subject.Type: GrantFiled: March 14, 2014Date of Patent: June 27, 2017Assignee: Eastern Virginia Medical SchoolInventor: David Taylor-Fishwick
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Patent number: 9688961Abstract: The present invention relates to testis somatic cell-derived pluripotent stem cells, and more particularly, to pluripotent adult stem cells which exhibit a positive immune reaction to both CD34 and CD73 and which are derived from testis somatic cells. The present invention further relates to a method for producing the testis somatic cell-derived pluripotent stem cells, and to a pharmaceutical composition including same for the treatment of erectile dysfunction.Type: GrantFiled: June 8, 2012Date of Patent: June 27, 2017Assignee: SUNGKWANG MEDICAL FOUNDATIONInventors: Dong-Ryul Lee, Won-Yun Choi, Tae-Ki Yoon
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Patent number: 9688962Abstract: The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing extracellular matrix remodeling and neovessel formation in an in vitro culture system and generating vascularized engineered tissue constructs using ultrasound technology.Type: GrantFiled: April 15, 2010Date of Patent: June 27, 2017Assignee: University of RochesterInventors: Diane Dalecki, Denise Hocking, Kelley Garvin
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Patent number: 9688963Abstract: Adhesive culture cells cultured by using a culture container made of a flexible film can selectively be released from the culture container without causing damage to the cells. A cell release method for releasing, from a culture container, adhesive culture cells cultured adhering to the culture container made of a flexible film includes bringing a surface of the film of the culture container into contact with the adhesive culture cells, applying a pressure to the adhesive culture cells, and releasing the adhesive culture cells from the culture container, wherein the surface of the film faces a surface of the film of the culture container to which the adhesive culture cells adhere.Type: GrantFiled: December 28, 2015Date of Patent: June 27, 2017Assignee: TOYO SEIKAN GROUP HOLDINGS, LTD.Inventors: Ryo Suenaga, Takahiko Totani
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Patent number: 9688964Abstract: There is described a process for production of metal-coated virus particles or metallic nanoparticles, said process comprising admixing virus particles with plant material with reducing power and a metal salt, wherein the process can be provided in planta or ex planta and the virus particles aid the production of the metal-coated virus particles or metallic nanoparticles.Type: GrantFiled: September 20, 2013Date of Patent: June 27, 2017Assignee: THE JAMES HUTTON INSTITUTEInventors: Andrew John Love, Mikhail Emmanuilovich Talianski, Sean Nicholas Chapman, Jane Shaw
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Patent number: 9688965Abstract: A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine.Type: GrantFiled: April 13, 2015Date of Patent: June 27, 2017Assignee: National Tsing Hua UniversityInventors: Suh-Chin Wu, Wen-Chun Liu, Chia-Ying Lin
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Patent number: 9688966Abstract: Enzyme compositions including at least a) a cocktail of cellulases from Trichoderma reesei, and b) an enzymatic cocktail from Pycnoporus cinnabarinus including a cellobiose dehydrogenase (CDH) or c) a recombinant cellobiose dehydrogenase (CDH) from Pycnoporus cinnabarinus, preferably also including a Family 61 glycoside hydrolase. Also, methods for degrading a lignocellulosic biomass, for producing a fermentation product, for producing gluconic acid, xylonic acid and/or xylobionic acid, for enhancing the production of gluconic acid, xylonic acid and/or xylobionic acid or for increasing the yield of sugars from a lignocellulosic biomass.Type: GrantFiled: July 4, 2012Date of Patent: June 27, 2017Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT FRANCAIS DU PETROLE ENERGIE NOUVELLE, AGRO INDUSTRIES RECHERCHES ET DEVELOPPEMENTSInventors: Jean-Claude Sigoillot, Jean-Guy Berrin, Mathieu Bey
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Patent number: 9688967Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.Type: GrantFiled: May 25, 2016Date of Patent: June 27, 2017Assignee: Synlogic, Inc.Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Suman Machinani
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Patent number: 9688968Abstract: The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same.Type: GrantFiled: May 15, 2014Date of Patent: June 27, 2017Assignee: INSTITUT NATIONAL DES SCIENCES APPLIQUEES (INSA)Inventors: Sophie Anne Michèle Bozonnet, Magali Martine Claude Remaud-Simeon, René-Marc Lucien Willemot, Pierre Emmanuel Frédéric Monsan
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Patent number: 9688969Abstract: The invention provides novel compositions with polymerase activity and methods of using the compositions.Type: GrantFiled: September 3, 2015Date of Patent: June 27, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Peter B. Vander Horn, Yan Wang
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Patent number: 9688970Abstract: A new, reliable, easily scalable and reproducible method for the production of recombinant butyrylcholinesterase (rBuChE) is provided. Through the utilization of a plant transfection procedure, various plant strains have been shown to generate effective and scalable amounts of rBuChE under acceptable manufacturing processes to permit reliable levels of such enzymes for desired nerve agent protection requirements (including tetrameric products). As well, such methods in engineered plant lines have shown suitable production of these enzymes in tetramer form with glycan formation and sialyalation (for terminal groups) to allow for optimal potency against organophosphorus agent exposure as well as proper immunogenic response within the plant sources. The overall production method, including the transfection and production within mammalian cells, as well as the process steps involved for such a reliable sourcing platform from plants is thus encompassed within the invention.Type: GrantFiled: July 31, 2014Date of Patent: June 27, 2017Assignee: Kentucky BioProcessing, Inc.Inventors: Greg Pogue, Ernie Hiatt, Romy Kandzia, Stefan Werner, Frank Thieme, Tsafrir Mor, Steven Hume
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Patent number: 9688971Abstract: The present disclosure provides variant Cas endoribonucleases, nucleic acids encoding the variant Cas endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Cas endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.Type: GrantFiled: June 13, 2013Date of Patent: June 27, 2017Assignee: The Regents of the University of CaliforniaInventors: Jennifer A. Doudna, Martin Jinek, Samuel H. Sternberg
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Patent number: 9688972Abstract: The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems.Type: GrantFiled: January 18, 2017Date of Patent: June 27, 2017Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Andrew Paul May, Paul Daniel Donohoue
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Patent number: 9688973Abstract: The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: GrantFiled: December 12, 2013Date of Patent: June 27, 2017Assignee: NOVOZYMES, INC.Inventors: Suzanne Otani, Haiyan Ge, Paul Harris, Debbie Yaver, Alexander Blinkovsky
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Patent number: 9688974Abstract: An Aspergillus mutant strain characterized in that it is an auxotrophic mutant strain of Aspergillus oryzae strain AOK27L.Type: GrantFiled: January 20, 2015Date of Patent: June 27, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka
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Patent number: 9688975Abstract: The present invention relates to beta-glucosidase variants, e.g. beta-glucosidase variants of a parent Family GH3A beta-glucosidase from Aspergillus fumigatus. The present invention also relates to polynucleotides encoding the beta-glucosidase variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the beta-glucosidase variants.Type: GrantFiled: September 30, 2011Date of Patent: June 27, 2017Assignee: Novozymes, Inc.Inventors: Mark Wogulis, Paul Harris, David Osborn
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Patent number: 9688976Abstract: Disclosed herein are a transformed Synechococcus elongatus strain having improved capability of producing acetone and a method for producing acetone and a method for removing carbon dioxide using the same. In an aspect, the transformed Synechococcus elongatus strain of the present disclosure can produce acetone with high selectivity using carbon dioxide as a carbon source. The present disclosure is economical because the Synechococcus elongatus strain can economically produce high value-added acetone using carbon dioxide existing in the atmosphere as a carbon source without requiring an additional catalytic reaction. Also, the present disclosure is environment-friendly because carbon dioxide in the atmosphere can be removed or reduced using the microorganism.Type: GrantFiled: March 1, 2016Date of Patent: June 27, 2017Assignee: Korea Institute of Science and TechnologyInventors: Han Min Woo, Youngsoon Um, Jun Won Chwa, Gyeongtaek Gong
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Patent number: 9688977Abstract: Various aspects and embodiments herein relate to recombinant proteins with at least one protease recognition sequence that can be inactivated by a cognate protease and methods of preparing such proteins. In some embodiments, recombinant phosphoglucose isomerase (Pgi) proteins are provided. In other embodiments, recombinant phosphotransacetylase (Pta) proteins are provided. In yet other embodiments, recombinant transketolase A (TktA) proteins are provided.Type: GrantFiled: August 5, 2014Date of Patent: June 27, 2017Assignee: GreenLight Biosciences, Inc.Inventors: William Jeremy Blake, Drew S. Cunningham
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Patent number: 9688978Abstract: The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.Type: GrantFiled: December 27, 2012Date of Patent: June 27, 2017Assignee: aTyr Pharma, Inc.Inventors: Ying Ji Buechler, Chi-Fang Wu, Ryan Andrew Adams, Jeffrey D. Watkins, John D. Mendlein
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Patent number: 9688979Abstract: The present invention relates to a method for producing a storable dry composition of biomolecule. First a composition is dispensed on a surface. The composition comprises at least a biomolecule, at least a liquid volatile component, at least a polysaccharide being designed for forming together with the at least a biomolecule and a part of the at least a liquid volatile component a matrix displaying a glass transition temperature Tg. Secondly, at least a part of the liquid volatile component is evaporated by adjusting the temperature of said composition to allow the formation of the matrix. Said evaporation step is initiated at an initial temperature T1, and finished up at a final temperature T2, said final temperature T2 being above said initial temperature T1.Type: GrantFiled: June 11, 2014Date of Patent: June 27, 2017Assignee: BIOCARTIS NVInventors: Anke Pierik, Henk Van Damme, Martijn Van Zelst, Rene Bakker, Pieter De Bokx
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Patent number: 9688980Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.Type: GrantFiled: December 16, 2014Date of Patent: June 27, 2017Assignee: NUEVOLUTIONInventors: Henrik Pedersen, Alex Haahr Gouliaev, Thomas Franch, Christian Klarner Sams, Eva Kampmann Olsen, Frank Abilgaard Slok, Gitte Nystrup Husemoen, Jakob Felding, Lene Hyldtoft, Mads Norregaard-Madsen, Michael Anders Godskesen, Sanne Schroder Glad, Thomas Thisted, Per-Ola Freskgard, Anette Holtmann
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Patent number: 9688981Abstract: The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.Type: GrantFiled: February 26, 2016Date of Patent: June 27, 2017Assignee: University of MassachusettsInventors: Job Dekker, Josee Dostie
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Patent number: 9688982Abstract: The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.Type: GrantFiled: October 11, 2013Date of Patent: June 27, 2017Assignee: CITY OF HOPEInventors: Hua Yu, Marcin Kortylewski, Richard Jove, Piotr Marek Swiderski, John J. Rossi