Abstract: Provided is a small-sized device for measuring an oxidation-reduction potential, whereby an oxidation-reduction current and an oxidation-reduction potential can be measured by reducing noise even when a signal from a solution being measured is small. A device for measuring an oxidation-reduction potential is provided with a substrate (10), a working electrode (15) mounted on a surface of the substrate (10), and a bipolar transistor (21) for amplifying the output of the working electrode (15) also provided on the surface of the substrate (10), and the signal amplified by the bipolar transistor (21) is inputted to a processing circuit (18).

Abstract: An analytical cell includes a first substrate with a first through hole formed therein, and a second substrate with first and second through holes formed therein. First and second solid portions protruding respectively from the first and second substrates are solid-state bonded together to form a solid state joint. By the solid state joint, the first and second substrates are joined together such that transmission membranes of the first and second substrates are mutually spaced by a predetermined distance, to form an overlapping portion. In the overlapping portion, an observation window is formed at a position where the first through holes face each other, and an accommodating part is formed between a lid member and the first substrate through the second through hole. One of negative and positive electrode active materials is provided in the accommodating part, and the other is provided between the transmission membranes of the observation window.

Abstract: The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer; allowing components of the sample to pass through the partly permeable layer into a channel; and separating the components into sections, such that each at least one of the sections substantially comprises a single type of the plurality of the types of charged species, and determining the charge concentration in the at least one of the sections.

Abstract: Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the complexes are incorporated into chromatographic media, affinity binding reagents, and dyes, which make the complexes useful in a wide range of assays, separations, and purifications. In addition, dinuclear metal complexes of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes that are not so conjugated are used in the detection of phosphate esters of biological species by either MALDI-TOF mass spectrometry or by dye displacement.

Abstract: UV-Absorbing and fluorescent pl markers for isoelectric focusing separations and fluorescent labeling, and methods for making and using the markers.

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Abstract: Provided is a fluid state identification device including a fluid state identification unit having a sensor part and a support part, and a cover surrounding the fluid state identification unit. The support part has a front surface part and a rear surface part which are located opposite to each other. The sensor part is located on the front surface part side. The cover has a lower opening and an upper opening. Inside the cover, a first fluid flow route running through a front area adjacent to the support front surface part and a second fluid flow route running through a rear area adjacent to the support rear surface part are formed and located so as to make the fluidity of the fluid in the second fluid flow route higher than the fluidity of the fluid in the first fluid flow route.

Abstract: Methods for ultrasonic inspection of a structure by laying a flexible two-dimensional flexible ultrasonic transducer array over a damage site on the structure with minimal physical interaction with the array during set-up and without further movement of the array during data acquisition. In addition, the array may remain in place on a difficult-to-access surface to enable easy periodic inspections over a long period of time. In some embodiments, the array is sandwiched between a flexible delay line substrate and a flexible display panel. In accordance with one wireless embodiment, a GPS receiver, a transceiver, pulser/receiver circuitry, and a source of electrical power (e.g., a battery) are attached to a portion of the flexible delay line substrate that extends beyond one edge of the array.

Abstract: A tool for inspecting the integrity of fasteners in their environment of use and methods of performing such inspections are disclosed and claimed. The tool includes a probe that matches the internal socket by which the fastener is coupled to the workpiece. The probe contains ultrasonic transducers on flat portions corresponding to flat portions of the socket. The transducers induce angled ultrasonic beams into the fastener to detect flaws therein. The beams are angled so they can be directed to the areas of interest at the head to shank region of the fastener. The presence of a defect such as a crack is determined based on the reply/echoes of the imparted ultrasonic beams.

Abstract: A device for determining properties of a medium, comprising a carrier which can be brought in contact with the medium; at least one transmitter arranged on the carrier for exciting acoustic waves in the carrier; at least one receiver arranged on the carrier for receiving acoustic waves which originate from waves excited in the carrier by means of the transmitter; and first and second material regions arranged on the carrier, wherein the second material region absorbs sound waves with the frequency of the acoustic waves excited in the carrier more strongly than the first material region. The carrier has a first surface with which it is to be brought in con-tact with the medium and a second surface which faces away from the first surface, wherein the transmitter as well as the first and the second material region are arranged on the second surface.

Abstract: A gas chromatography equipment includes a sample introducer, a detector, a column module, and an oven including a housing. A sub-space is provided in a projection section projecting downward from a portion of a bottom face of the housing communicates with a main space of the housing. A column module attaching section is provided outside the housing and below the main space. A fixed side face, which faces the column module attaching section, of the projection section serves as an attachment face for attaching the column module. The column module is attached to the housing in such a way that the main flat surface of the column module is horizontally positioned with an end face of the column module being the attachment face.

Abstract: Provided is a chromatography column stored in a storage container. The storage container for the column includes: a container body for storing the chromatography column; and a cover threadedly engaging with the container body. A groove for threaded engagement with the cover is formed in an inner wall of the container body. Sealing members are arranged on an inner bottom surface of the container body and a lower surface of the cover, respectively. When the container body and the cover are threadedly engaged with each other, the cover enters the container body to cause the sealing members on the inner bottom surface of the container body and the lower surface of the cover to press both a lower surface and an upper surface of the column, to thereby fix the column inside the container body and seal a fluid passage hole of the column.

Abstract: A colorimetric time indicator configured to indicate time specificity is provided. The colorimetric time indicator includes a colorimetric layer configured to be operatively coupled to a disposable medical device. The colorimetric time indicator is configured to indicate the time specificity via one or more visual indicators upon exposure to one or more external stimuli.

Abstract: A system for controlling an atmospheric condition. The system includes: a pre-atmospheric conditioner configured to: collect ambient air and generate test air comprising the atmospheric condition for a first test computing device by modifying the ambient air. The system also includes an intake conduit, external to the first test computing device, configured to channel the test air to the first test computing device.

Abstract: A heatable gas analysis device which is monitored in a simply way, wherein a gas analysis device contains a monitoring unit which, after the device is switched on and until a predefined operating temperature is reached, generates a two-dimensional temperature profile from temperature progressions measured at different measuring points within the device, in which temperature profile one dimension indicates time and another dimension indicates the different measuring points, where the monitoring unit compares the temperature profile to a reference temperature profile generated and stored under reference conditions and, in the event of any deviation exceeding a predefined amount, generates an error message.

Abstract: A sensing system for selective analyte detection in presence of interferences is presented. The sensing system includes an inductor-capacitor-resistor (LCR) resonant sensor includes a substrate, a plurality of first sensing elements mutually spaced apart and disposed on the substrate, a plurality of second sensing elements, each second sensing element disposed overlapping a corresponding first sensing element of the plurality of second sensing elements, and a protecting film applied onto the plurality of first sensing elements and the plurality of second sensing elements, wherein the protecting film is disposed to be in a physical contact with the analyte and is configured to enable an operational contact of the plurality of first sensing elements and the plurality of second sensing elements with the analyte.

Abstract: A hazard detector includes a chassis configured to house components of the hazard detector. The chassis includes a front defining a central aperture. The front has a domed contour such that an outer edge of an inner portion extends beyond an outer periphery of the front. The inner surface tapers from the outer edge toward the inner portion. The detector includes a mesh formed to the contour of the front so the mesh is flat against the front. The mesh defines an aperture corresponding to the central aperture. The detector includes a grille secured to the chassis that defines an aperture corresponding to the central aperture and defines openings positioned along the grille. An inner surface of the grille includes a contour corresponding to the contour of the front so the mesh is flat against the inner surface. The mesh is positioned between the grille and the chassis.

Abstract: A food safety detection device includes a xylem fiber substrate, which is configured with a sampling portion and a reaction portion. The reaction portion includes at least one chemical reagent. The sampling portion absorbs a test sample. The test sample moves on the xylem fiber substrate to the reaction portion and reacts with the chemical reagent. A manufacturing method for the food safety detection device is also disclosed. The food safety detection device is advantageous for easy operation, safety and rapid analysis.

Abstract: Provided are multi-parameter sonde systems having a unique form-factor, wherein the plurality of sensors are arranged in a tight-fit configuration. This provides a single distal sensing surface and minimal separation distance between adjacent sensors. The sensors may be pie shaped with an interlocking feature to tightly hold the sensors together, with a sensor guard disposed over the outer surface of the interlocked sensors. Sensor-guards disclosed herein may have an integrated sensor storage and sensor guard configuration, thereby avoiding a need for a separate storage cup and that are configured to minimize unwanted biological growth. Also provided are uniquely shaped individual sensors having interlocking features to hold several sensors together in a sonde.

Abstract: Compositions and methods are provided for assessing the presence or absence, and optionally quantitating, the surface loading of a noble metal such as platinum on the surface of a substrate. The invention utilizes the decomposition rate of hydrogen peroxide (H2O2) or other redox active molecule following exposure to the substrate surface to effectively establish a qualitative or quantitative correlation between the redox agent survival fraction and the presence or absence of noble metal (e.g., platinum), and further, for the quantitation of noble metal loading on the substrate surface. The invention finds applicability in assessing the surface loading of noble metals on the internal surfaces of boiling water nuclear reactor plants (BWR) that have undergone prior noble metal application.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: A method for determining an asphaltene onset condition of a crude oil is provided. The method includes receiving a crude oil within a downhole tool inside a well and taking a first measurement of an optical property of the received crude oil. The method also includes lowering the pressure or temperature of the crude oil after taking the first measurement of the optical property to cause aggregation of asphaltenes in the crude oil, and then separating aggregated asphaltenes from the crude oil. Further, the method includes taking a second measurement of the optical property of the crude oil within the downhole tool after separating aggregated asphaltenes from the crude oil and determining an asphaltene onset condition of the crude oil through comparison of the first and second measurements of the optical property. Additional methods, systems, and devices are also disclosed.

Abstract: A gas chromatographic method for detecting a first marker and a second marker in a fuel in two channels: (i) a first capillary column coated with polysiloxane and a second capillary column coated with polyethylene glycol; and (ii) a third capillary column coated with polymethylphenylsiloxane and a fourth deactivated capillary column. The steps are: (a) introducing a first sample into the first column to produce a first effluent; (b) introducing only a portion of the first effluent into the second column to produce a second effluent; (c) allowing the second effluent to pass through a mass spectrometer; (d) introducing a second sample into the third column to produce a third effluent; (e) introducing only a portion of the third effluent into the fourth column to produce a fourth effluent; (f) allowing the fourth effluent to pass through a mass spectrometer.

Abstract: A concrete test cylinder mold formed of expandable polystyrene and which is used to form geometrically uniform concrete test cylinders that accurately reflect the structural properties of the concrete mix used to form the test cylinders despite fluctuations in temperature to which the test cylinder may be exposed during formation within the mold. The mold is constructed and configured such that compression testing of the concrete test cylinder may be conducted while the cylinder is still in the mold. A specially designed heat shield may be used in unison with the concrete test mold to form, at least in part, a system by which heat further may be retained within the system during formation of the concrete test cylinder.

Abstract: A concrete test cylinder mold formed of expandable polystyrene and which is used to form geometrically uniform concrete test cylinders that accurately reflect the structural properties of the concrete mix used to form the test cylinders despite fluctuations in temperature to which the test cylinder may be exposed during formation within the mold. The mold is constructed and configured such that compression testing of the concrete test cylinder may be conducted while the cylinder is still in the mold. A specially designed heat shield may be used in unison with the concrete test mold to form, at least in part, a system by which heat further may be retained within the system during formation of the concrete test cylinder.

Abstract: The present invention relates to an antigen binding protein, in particular a monoclonal antibody, capable of binding specifically to the protein Axl as well as the amino and nucleic acid sequences coding for said protein. From one aspect, the invention relates to an antigen binding protein, or antigen binding fragments, capable of binding specifically to Axl and, by inducing internalization of Axl, being internalized into the cell. The invention also comprises the use of said antigen binding protein as an addressing product in conjugation with other anti-cancer compounds, such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: Among others, the present invention provides micro-devices for detecting or treating a disease, each comprising a first sorting unit capable of detecting a property of the biological subject at the microscopic level and sorting the biological subject by the detected property; a first detection unit capable of detecting the same or different property of the sorted biological subject at the microscopic level; and a first layer of material having an exterior surface and an interior surface, wherein the interior surface defines a first channel in which the biological subject flows from the first sorting unit to the first detection unit.

Abstract: A method of determining the concentration of an analyte of interest in breath. The method includes obtaining a disposable cartridge comprising a reaction chamber, a liquid chamber, and a window to permit determination of a color intensity in the reaction chamber, directing a volume of breath into the cartridge, and initiating a sequence whereby liquid is released from the liquid container into the reaction chamber to cause a reaction which produces a change in the intensity of a color viewable through the window. The intensity of the color corresponds to the concentration of the analyte of interest. The reaction progresses through a kinetic phase and eventually reaches equilibrium. The sequence additionally includes measuring the intensity of the color at a point in the kinetic phase, to determine the concentration of the analyte of interest in breath.

Abstract: The present invention provides a personal hygiene item. In simple terms, one of the main features of the present invention is to provide a low-cost personal hygiene item capable of providing a multi-component detection function. The personal hygiene item of the present invention mainly comprises a first material layer and a second material layer. The first material layer is made of hydrophobic material, and the second material layer is disposed thereon. Also, the second material layer comprises a discolored portion. In actual practice, a fluid under test contacts with the corresponding discolored portions via the hydrophobic layer of second material layer for a color changing reaction. Meanwhile, since the hydrophilic performance of the discolored portion is better than the hydrophilic performance of the hydrophilic layer, the back permeation of the fluid under test can herein be prevented.

Abstract: A device for remote management of patients suffering from heart failure and hypertension can measure one or more biomarker. The device aids in monitoring the efficacy and safety of treatment in such patients.

Abstract: Methods, compositions and kits are disclosed for assays to determine the binding affinity of DNA-binding proteins or RNA-binding proteins for their corresponding recognition site(s). In particular, assays are disclosed for measuring binding affinities when either the binding protein, or the recognition sequence of the recognition site, or cofactor proteins, contain one or more mutations. The disclosed assays can thus be utilized to measure the effect on transcription factor binding caused by mutations within the recognition site, or mutations within the binding domain of the protein, and to provide binding affinity information that can be correlated with altered gene regulation and expression. The disclosed assays can be personalized to a specific person or organism, with the measured binding affinities based upon an individual's specific binding proteins and recognition sites.

Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.

Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.

Abstract: An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone. The reagent cells divide the sample flow from the sample zone into multiple flow streams. Also includes are: one or more flow control elements disposed downstream from the reagent zone which combine the multiple flow streams into fewer flow streams; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path.

Abstract: Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.

Abstract: The present invention provides a method using immunoassay devices to differentiate infection with HIV-2 from infection with both HIV-1 and HIV-2 in a subject.

Abstract: Disclosed herein are panels related to the diagnosis or recognition of colon and colorectal cancer in a subject. The disclosed panels and related methods are used to predict or assess colon tumor status in a patient. They can be used to determine nature of tumor, recurrence, or patient response to treatments. Some embodiments of the methods include generating a report for clinical management.

Abstract: The present application provides methods and systems for detecting both CD3 and CD16 in a sample using immunohistochemical methods, for example when the primary antibodies for CD3 and CD16 are from the same species (e.g., both rabbit antibodies). Methods to denature and block the first primary antibody contacted with the sample are provided.

Abstract: The present invention relates to method for predicting a subject's relative response to cancer immunotherapy treatment. The methods involve providing a sample comprising a tumor cell or a peripheral blood cell from the subject; measuring the expression level of matrix metalloproteinase-23 (“MMP-23”) by the tumor cell or the peripheral blood cell; comprising the measured expression level of MMP-23 with a control or standard value; and determining the subject's predicted response to cancer immunotherapy, where, based on said comparing, a higher MMP-23 expression level compared to the control or standard value predicts the subject will have a poor response to cancer immunotherapy. The present invention also relates to methods for increasing production of tumor infiltrating leucocytes (“TILs”) in a subject, methods of identifying a subject as a candidate for adoptive T-cell therapy using T-cells that primarily express KCa3.

Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): Formula (I), including stereoisomers, salts and tautomers thereof, wherein R1a, R1b, R2a, R2b, R2c, R2d, R2e, R2f, R2g, R2h, R2i, R2j, R2k, R2l, R2m, R2n, R2o, R2p, R2q, R2r and R2s are as defined herein. Methods associated with preparation and use of such compounds are also provided.

Abstract: Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds of included target materials are prepared. The plurality of encoded particles are provided onto a plate including a plurality of wells by pipetting, and disposed in the plurality of wells by a self-assembly method. An analyte is provided into the plurality of wells. The codes of the plurality of encoded particles disposed in the plurality of wells are decoded. The target materials of the plurality of encoded particles are released to cause a reaction between the target materials and the analyte.

Abstract: The present invention relates to a method for the production of a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 as well as a method for selecting from a library comprising recombinant derivatives of the SH3 domain of the Fyn kinase of SEQ ID NO: 1 one or more of said derivatives having a specific binding affinity to a protein or peptide.

Abstract: Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.

Abstract: A method for separating target molecules or particles from a fibrinogen containing sample comprises: (a) trapping the said target molecules or particles in a fibrin network by converting at least partially the fibrinogen contained in the sample into fibrin; (b) retracting the said fibrin network to form a fibrin clot; (c) separating the said fibrin clot from the surrounding sample medium.

Abstract: A monitoring system monitoring an environmental condition of an area by measuring an environmental quantity, including: a static monitoring section including plural static sensor units each configured to collect first measure data relating to the environmental quantity in respective portions of the area; a mobile monitoring section including at least one robot configured to move within the area to collect second measure data relating to the environmental quantity in a portion of the area surrounding the robot; and a central unit communicating with the static sensor units and robot to perform: conditioned to assessing an anomalous environmental condition from first measure data collected by at least one static sensor unit, commanding the robot to operate according to anomaly routines, and conditioned to assessing an anomalous environmental condition from second measure data collected by the robot, commanding at least one static sensor unit to operate according to anomaly routines.

Abstract: To provide an automated analyzer with a built-in, user-friendly printer that can avoid contamination of printed paper of the printer by having a housing front wall 102 provided in a recessed manner from a front end 101 of a housing upper portion that has disposed thereon a sample disc 110, a reagent disc 120, a reaction disc, a sample dispensing mechanism, and a reagent dispensing mechanism, and by having a printer 200 and a paper receptacle 210 disposed on the housing front wall. The front end portion of the housing upper portion that projects beyond the housing front wall serves as eaves, thereby preventing a sample or a reagent that may be spilled on the housing upper portion from staining the printer or printing paper.

Abstract: A metering apparatus includes a base and a vertical support coupled to the base and extending upwardly from the base. The metering apparatus also includes a transverse support coupled to the vertical support, vertically spaced from the base. The metering apparatus also includes a pipetting device coupled to the transverse support, the pipetting device including at least one pipetting channel configured to attach to a pipetting tip. The metering apparatus also includes a disposal container configured to receive used pipetting tips from the pipetting channel, detachably coupled to the vertical support. The pipetting device is movable in first, second, and third directions substantially orthogonal to each other. The disposal container is moveable in one of the first, second, and third directions.

Abstract: A sensor unit includes a sensor and a mount board on which the sensor is mounted. The mount board includes a mount terminal connected to a terminal provided in the sensor and a wiring extending from the mount terminal. The wiring is not provided in a region where the sensor and the mount board overlap each other when viewed in plan.

Abstract: A flow angle probe is provided comprising: (a) a probe vane configured to contact a moving fluid within a fluid conduit; (b) an optional probe mounting mechanically coupled to the probe vane; (c) a rotary shaft coupled either to the optional probe mounting or the probe vane; (d) a rotary encoder coupled to the rotary shaft; (e) a sensor hermetically isolated from the probe vane and configured to sense a change in position of the rotary encoder; and (f) a probe housing encompassing at least a portion of the rotary shaft, the rotary encoder and the sensor. The novel flow angle probes disclosed herein may be used in a wide variety of turbomachines and fluid processing systems, and applications, including turbomachine design and operational control, as well as in flow assurance.