Abstract: An arrangement in connection with a low pressure suction apparatus for mobilizing skin tissue comprises a low pressure chamber, a suction equipment, comprising for example a pump or a fan, for producing low pressure in the low pressure chamber, and a suction head in connection with the suction apparatus, the suction head comprising a suction cup, one end of which is arranged to be in functional connection with the low pressure chamber and the other is arranged to be pressed against skin tissue, said other end of the suction cup forming a suction opening having a suction opening surface, and the direction parallel to the surface normal of the suction opening surface forming an angle deviating from zero degrees relative to the direction parallel to the surface normal of said one end of the suction cup. An extension handle for a suction apparatus is disclosed.

Abstract: An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

Abstract: An embodiment of a system for treating sleep apnea includes a collar, a pump, a motor, a sensor, and a controller. The collar is configured to maintain an airway of a subject open while the subject is sleeping by applying, to a throat of the subject, a negative pressure having a magnitude, and the pump is configured to generate the negative pressure. The motor is configured to drive the pump, and the sensor is configured to generate a sense signal that is related to a degree to which the airway is open. And the controller is configured to vary the magnitude of the negative pressure in response to the sense signal. For example, one or more of the pump, motor, sensor, and controller can be secured to the collar such that the system is self-contained, i.e., the entire sleep-apnea system can be worn by the subject.

Abstract: A pulmonary expansion therapy (PXT) device may be a handheld device that covers specific lung fields and may generate negative pressure fields locally. The device also may provide vibratory/percussion therapy for airway clearance. The PXT may generate a localized negative pressure field non-invasively to the exterior of the chest wall, thereby increasing the functional residual capacity in underlying lung fields. As a result, increased ventilation and perfusion to the targeted internal lung field may be achieved by creating a decrease in the external barometric pressure relative to the more positive intrinsic airway pressures. The PXT device also may improve lung compliance by enabling a medical professional to grab and elevate the chest wall to compensate for the dysfunction of the respiratory musculature responsible for lifting the chest wall. In some embodiments, once a targeted functional residual capacity (FRC) has been established, vibration or percussion may be applied.

Abstract: An intermittent and sequential compression device accommodates an angular placement and application of the device as used within a limb support. The support can incorporate a variety of supports and braces of the type that can be used with human limbs, and the joints of such limbs, in particular. Disposed within the support is a plurality of sequentially-disposed and intermittently inflatable and deflatable air chambers. Each air chamber has an air inlet port and an air outlet port, which can be the same structure or different structure. Each chamber port is to the first end of an air-passage tube. The second end of the air-passage tube is connected a pneumatic pump, the pneumatic pump being connected to an electric power supply and to a controller. The controller operates in accordance with a pre-programmed scheme to alternate the inflation and deflation of the air chambers.

Abstract: A leg massage apparatus is provided which enables the user to easily and comfortable engage the various muscles of the leg, providing the leg muscles with a therapeutic massage which helps to loosen and relieve sore or damages muscles. The apparatus may also be used to assist in the removal of cellulite from areas of the leg. The apparatus is basically comprised of a name structure means, a user engagement means, a coupling means, and an optional resistance means. The frame structure means has at least two main support members coupled together in such a manner that the leg of the user may be placed within, with the main support members surrounding a significant portion of the leg. The main support members are adjustably coupled together by the coupling means such that they may alternatively move away and towards one another, as the various leg muscles of the user are being engaged by the user engagement means. The optional resistance means may be used to provide motion resistance.

Abstract: A system for adding pressure and extracting heat from the bottom of a user's foot to aid in pain relief. A spherical container is provided with an aqueous polymer mixture which may be cooled or heated to allow heat to be transferred through the spherical container to/from the bottom of a user's foot. The spherical container is provided with a tube passing therethrough to allow a user to provide a strap through the spherical container.

Abstract: The present invention relates to a method for treating the kidney with extracorporeal shockwaves in a noninvasive manner and in particular, to such a method for the treatment of the nephrons about the glomerulus.

Abstract: A pair of gloves for performing cardiopulmonary resuscitation (CPR) is disclosed. The left hand glove comprises a sensor detector in form of heart shape, or the like. The right hand glove is provided with green and red light sensors in the shape of arrows. In use, the left hand glove is placed over a patient's heart for detecting heartbeats wherein the right hand glove's green light sensor indicates when it's time to blow into the patient's lungs and red light sensor indicates when it's time to push down and pump the patient's chest.

Abstract: An apparatus for assisting a rescuer in performing chest compressions during CPR on a victim, the apparatus comprising a pad or other structure configured to be applied to the chest near or at the location at which the rescuer applies force to produce the chest compressions, at least one sensor connected to the pad, the sensor being configured to sense movement of the chest or force applied to the chest, processing circuitry for processing the output of the sensor to determine whether the rescuer is substantially releasing the chest following chest compressions, and at least one prompting element connected to the processing circuitry for providing the rescuer with information as to whether the chest is being substantially released following chest compressions.

Abstract: A resuscitation system for use by a rescuer for resuscitating a patient, comprising at least two high-voltage defibrillation electrodes, a first electrical unit comprising circuitry for providing resuscitation prompts to the rescuer, a second electrical unit separate from the first unit and comprising circuitry for providing defibrillation pulses to the electrodes, and circuitry for providing at least one electrical connection between the first and second units.

Abstract: Container holder assembly for use in a medicament delivery device, comprising a tubular body elongated in an axial direction, said tubular body having a proximal end and an opposite distal end, and a retaining member releasably arranged to said tubular body for securing an elongated container placed inside the tubular body, wherein said retaining member comprises a resilient structure capable of exerting an axial force on said container in said tubular body for holding the container in a fixed position inside the tubular body and thereby avoiding displacement or breakage of the container and wherein a distal end of said container protrudes from a distal end of said tubular body.

Abstract: Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed which provide for passive warming of chilled injectable transferred through the transfer apparatus and into the injection device. The injection device may include a skin-facing surface including a skin boundary displacement extension or structure around a needle injection site to create a high pressure zone in the tissue. Radio frequency tracking and monitoring features for tracking patient compliance also may be provided.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: The present invention is a bracelet that contains a cartridge holding a plurality of interior storage compartments that are each designed to hold one or more pills. A sliding door is used to withdraw the pills from any one compartment at a time. The bracelet comprises electronic components that enable it to activate a vibrating alarm at a prearranged time to remind the user to take her pills, and to track when the door has been opened to withdraw the pills, and to communicate the alarm and tracking information to an external electronic device, such as a mobile phone, via Bluetooth wireless communication.

Abstract: Generally provided herein is a device for the delivery of liquids. In particular, a delivery device that attaches to a nipple and increases the accuracy and comfort when delivering medication to an infant/child.

Abstract: The invention is directed to an absorbent neck ring for a baby bottle which is disc shaped with an aperture at the center. The ring is fitted to the bottle, preferably with elasticized cotton or other elastic fabric such that the aperture passes over the bottle opening and is secured below the screw fixtures when the cap is attached to the bottle. The ring ensures that any leaks from the bottle or the baby's mouth will be absorbed, rather than dripping on clothing or elsewhere. The ring may be laundered and re-used, or it may be used in a single use capacity. The ring may be provided in various colors and decorative configurations, such as an image of a teddy bear's face or a baseball.

Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.

Abstract: The present invention provides a dental adhesive exhibiting excellent initial bond strength and bond durability to both enamel and dentin. The present invention relates to a dental adhesive containing: an asymmetric acrylamide-methacrylic acid ester compound (a); an acid group-containing (meth)acrylic polymerizable monomer (b); and a water-soluble polymerizable monomer (c). The asymmetric acrylamide-methacrylic acid ester compound (a) is represented by the following general formula (1): where X is an optionally substituted, linear or branched C1 to C6 aliphatic group or an optionally substituted aromatic group, the aliphatic group is optionally interrupted by at least one linking group selected from the group consisting of —O—, —S—, —CO—, —CO—O—, —O—CO—, —NR1—, —CO—NR1—, —NR1—CO—, —CO—O—NR1—, —O—CO—NR1—, and —NR1—CO—NR1—, and R1 is a hydrogen atom or an optionally substituted, linear or branched C1 to C6 aliphatic group.

Abstract: Disclosed are a cosmetic composition containing an amphiphilic anisotropic powder and a method for preparing the same. The cosmetic composition contains an amphiphilic anisotropic powder which maximizes chemical interface activity and physical interface activity by controlling amphiphilic property, which is the characteristic of an existing surfactant, and geometric property, which is the characteristic of powder macroparticles, thereby forming an emulsion having excellent and stabilized emulsifying capacity.

Abstract: The invention relates to a foaming cleanser cosmetic composition containing, in a physiologically acceptable medium: —a surfactant system comprising (i) at least one N—(C6-C30)acyl-amino based surfactant and (ii) at least one amphoteric surfactant chosen from betaines or (C8-C20)alkyl betaines, (C8-C20)alkylamido(C1-C6)alkylbetaines and mixtures thereof; and—at least one non associative crosslinked copolymer or acrylic acid and/or methacrylic acid, and optionally of (C1-C4)alkyl esters thereof, wherein said N—(C6-C30)acyl-amino based surfactant being present in the surfactant system in a major weight amount, and the surfactant system being present in the composition in an amount of less than 15% by weight relative to the total weight of the composition.

Abstract: The present invention relates to a solid anhydrous composition comprising: 1) at least particles comprising a core containing at least one beneficial agent and an envelope surrounding the core; said envelope comprising at least one hydrophobic-modified polysaccharide and at least one water-soluble carbohydrate and/or water-soluble polyol; said particles simultaneously having a poured powder density ranging from 300.0 g/l to 600.0 g/l and an absolute density of greater than 1.0; and 2) at least one structuring agent. The invention also relates to a cosmetic process for caring for and/or for the hygiene of and/or for conditioning and/or for fragrancing and/or for making up a keratin material, which consists in applying to said keratin material a composition as defined previously.

Abstract: The present invention generally relates to compositions and methods for transdermal delivery, treatment of skin, and improving the appearance of skin. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Abstract: A storage stable package is provided that includes a polymeric bottle having a volume filled with an aqueous saline composition acidified with an acid to a pH of 2 to 9 and having a hypertonic saline concentration relative to saliva and blood, or an aqueous hydrogen peroxide composition acidified with an acid to a pH of 2.7 to 5.3 and having a hydrogen peroxide concentration 0.5 to 3 total weight percent, either to achieve a storage stability at 20 degrees Celsius of the composition of at least 10 weeks. The aqueous composition is independent of a synthetic antimicrobial. A cap is provided that is complementary a package opening for selectively sealing the aqueous saline composition within the volume. A process for treating an infection of a pharyngeal or buccal cavity is provided that includes rinsing with one of the aqueous saline composition. The aqueous saline composition is then expectorated.

Abstract: The present invention relates generally to oral care compositions, and more specifically to oral care compositions suitable for cleaning the oral cavity. Methods of use are also disclosed.

Abstract: Present invention is on an anhydrous solid conditioning and styling, composition for keratin fibres, especially human hair. The object of the present invention is a solid anhydrous composition for keratin fibres, especially for human hair, comprising at least one polyol liquid at 20° C. at a concentration 50% or more by weight and at least one fatty acid soap at a concentration of 5% or more by weight, all values calculated to total composition, wherein the composition is free of volatile organic solvents, especially C1-C4 aliphatic alcohol.

Abstract: Compositions are provided that provide fragrance over an extended period of time. The compositions comprise a fragrance and one or more other ingredients.

Abstract: Disposable wipes comprising of warming lubricants, glycerol and capsaicin, vitamin E oil, essential oils, Lavender and Lemon, and propyl paraben. The fragrance free disposable wipes comprises of 85% purified water, 0.4.% glycerol, 0.1% capsaicin, 0.9% vitamin E oil, and 0.1% propyl paraben. The disposable wipes with fragrance comprises of 80% purified water, 0.4.% glycerol, 0.1% capsaicin, 0.9% vitamin E oil, 0.5% of either the essential oils, Lavender or Lemon, and 0.1% propyl paraben. The warming effect is achieved by having one or more additives in the lubricant which are either always active or activated by your body.

Abstract: The present invention is directed to combination sunscreen and insect repellant compositions. The combination sunscreen and insect repellant compositions contain (i) diethyl toluamide (or N,N-Diethyl-3-methylbenzamide or DEET), (ii) one or more sunscreen components, with each sunscreen component being capable of absorbing ultraviolet light rays, and (iii) a polymeric binder system. The combination sunscreen and insect repellant compositions may contain additional composition components such as butyloctyl salicylate, a crosslinked polyacrylate polymer, and deionized water. The present invention is also directed to methods of making and using combination sunscreen and insect repellant compositions.

Abstract: Some methods for preventing or reducing oral and epidermal malodor by the use of formulations for reducing bacteria are introduced, including applying various formulations for reducing bacteria to the oral cavity, the nasal cavity, and/or the epidermis of a user or an animal. The formulations for removing and/or reducing bacteria are applied to the oral cavity via delivery devices, including, but not limited to, a toothbrush, aerosol can, roll-on bottle, bar, and bottle, and the oral formulations for reducing bacteria can take various forms, including, but not limited to, a liquid, pellet, powder or granule, cream, spray or stick.

Abstract: A hair dye composition comprising the following components (A), (B) and (C) and having pH (25° C.) of 7.5 or more and 12 or less: (A): one or more azo dyes selected from the group consisting of the following (A-1), (A-2) and (A-3): (B): a cationic compound (C): 0.1 mass % or more and 8 mass % or less of at least one alkali metal salt of an acid selected from the group consisting of hydrochloric acid, carbonic acid and sulfuric acid.

Abstract: A hair dye composition comprising the following components (A) and (B), in which the mass ratio of the component (B) to the component (A), (B)/(A), in a whole composition is 1 or more and 100 or less and the pH (25° C.) during application is 7.5 to 12: (A): one or more azo dyes selected from the group consisting of the following (A-1), (A-2) and (A-3): (B): at least one member selected from the group consisting of guanidine carbonate, guanidine hydrogen carbonate, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate and lithium carbonate.

Abstract: A hair dye composition comprising the following components (A) and (B), in which the mass ratio of the component (B) to the component (A), (B)/(A), in a whole composition is 1 or more and 100 or less and the pH (25° C.) during application is 7.5 to 12: (A): one or more azo dyes selected from the group consisting of the following (A-1), (A-2) and (A-3) (B): 2-amino-2-methylpropanol.

Abstract: The present invention relates to compositions for and methods of retarding hair loss or facilitating hair growth comprising a hair growth active and a C8-C24 alcohol ester of a carboxylic acid.

Abstract: The present invention relates to a dentifrice composition which removes a fine stain and a stain adhering to the surface of teeth sufficiently, enhances the whitening effect on teeth and the gloss-imparting effect on teeth, also increases the amount of fluorine adsorption to teeth, and decreases the feeling of astringency. The oral composition of the present invention comprises the following component (A): phytic acid or an alkali metal salt thereof in an amount of 0.04% by mass or more and 1% by mass or less in terms of phytic acid; and component (B): monofluorophosphoric acid or an alkali metal salt thereof in an amount of 500 ppm or more and 1500 ppm or less in terms of fluorine atoms, wherein a mass ratio of the component (A) to the component (B), ((A)/(B)), is 0.1 or more and 1.

Abstract: Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Abstract: Described herein is a silicone replacement for use in a personal care formulation comprising a mixture of at least one polymeric ester and at least one non-polymeric ester. The polymeric ester is an esterification reaction product of (i) at least one first dicarboxylic acid, (ii) at least one first monofunctional alcohol or monofunctional carboxylic acid and (iii) glycerin or derivatives thereof. The non-polymeric ester is an esterification reaction product of (i) at least one second dicarboxylic acid and (ii) at least one second monofunctional alcohol, wherein the replacement is substantially free of silicone. As described is a personal care formulation that is substantially free of silicone, wherein the formulation comprises a silicone replacement consisting substantially of a mixture of at least one polymeric ester as described above, and a non-polymeric ester as described above. Related methods are also described.

Abstract: Disclosed is a composition containing Glycine gracilis oil as an active ingredient and, particularly, a composition having uses of anti-oxidation, anti-aging, anti-wrinkles, whitening, anti-inflammation, anti-acne, moisturization, atopy alleviation, skin barrier improvement, and the like.

Abstract: Body scrub compositions and methods for forming body scrub compositions are provided herein. In one embodiment, a body scrub composition includes safflower oil, argan oil, and manila oil. Further, the body composition includes silica as a suspension agent.

Abstract: A skincare stimulant having an effective dose of platelets and pharmaceutically acceptable solvents and/or excipients, wherein the effective dose refers to the presence of at least 1000 platelets in every milligram of skincare stimulant.

Abstract: Described herein are systems and methods for transmucosal delivery of active agents. In some embodiments, a system may comprise one or more mucoadhesive devices configured for release of an active agent.

Abstract: A method is provided comprising steps for (a) dispensing a topical product having a set of ingredients, wherein the set of ingredients provides pain relief to an affected area of a user; and (b) delivering the topical product via a sonic device to the affected area of a user, wherein the affected area includes joint inflammation, wherein the sonic device comprises an elongated body having an massager head receiving area designed to receive a massager head, the combination of the sonic device and the attached massager head producing a vibrating massager promoting optimal absorption of the set of ingredients designed to stimulate and increase blood flow to the joint inflammation providing a reduction of pain for the user, wherein the sonic device and topical product are packaged together in a single packaging unit.

Abstract: The invention relates to extended-release formulations comprising: (i) a poorly water-soluble active pharmaceutical ingredient; and (ii) a non-aqueous liquid vehicle comprising (a) a hydrophobic lipid comprising a glyceryl ester of a C6-C24 fatty acid, or (b) a hydrophilic organic compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, and dimethylsulfoxide, or (c) a combination of (a) and (b), and (iii) an amphiphilic agent wherein the active pharmaceutical ingredient is dispersed as discrete particles having a D90 particle size of about 0.5 ?m to about 25 ?m in the formulation, and wherein the formulation is non-gelling and thixotropic with a viscosity of less than 10 poise at a shear rate of 10/s at 25° C.

Abstract: A method of alleviating a symptom of relapsing-remitting multiple sclerosis in a human patient suffering from relapsing-remitting multiple sclerosis or a patient who has experienced a first clinical episode and is determined to be at high risk of developing clinically definite multiple sclerosis comprising administering to the human patient three subcutaneous injections of a therapeutically effective dose of glatiramer acetate over a period of seven days with at least one day between every subcutaneous injection so as to thereby alleviate the symptom of the patient.

Abstract: A method for treating ear infections in animals includes forming a liquid composition having an antifungal agent, an antibiotic agent, a steroidal anti-inflammatory agent, an anhydrous organic acid, liquid dehydrated alcohol, and propylene glycol. The treatment method includes applying several drops of such composition inside the ear of the animal at least twice per day to the affected area of the animal's ear until the ear infection has been cured. The antifungal agent may include ketoconazole. The antibiotic agent may include ofloxacin. The steroidal anti-inflammatory agent may include triamcinolone diacetate. The anhydrous organic acid may include citric acid.

Abstract: An ophthalmic composition for administration to an eye of a patient for the treatment of an ocular infection. The ophthalmic composition contains an ?-polylysine (?PL) in an amount effective to treat or control or prevent the ocular infection.

Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing endogenous MCP-1, a MCP-1 antagonist, a substance capable of suppressing endogenous TNF-alpha, a TNF-alpha antagonist, a substance capable of suppressing endogenous IL-1 beta, an IL-1 beta antagonist, a substance capable of inducing endogenous bFGF, exogenous bFGF, a bFGF mimetic, and combinations thereof, to a mammal having an eye with retinal detachment. The neuroprotective agent maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

Abstract: Provided are a propofol-containing oil-in-water emulsion composition having high stability even in a case in which the emulsion composition is charged into a plastic container; and a method for producing the same. Provided is a propofol-containing oil-in-water emulsion composition including at least one selected from the group consisting of trishydroxymethylaminomethane, phosphoric acid, and triethanolamine; propofol; an oily component; an emulsifier; and water, in which a dissolved oxygen concentration is 5 mg/L or less and an average emulsion particle size is 180 nm or less.

Abstract: The invention discloses a new method of obtaining a pharmacologically active product that is a liposomal composition of phospholipid phosphatidylcholine and physiologically active substance—quercetin (3,3?, 4?, 5, 7-pentaoxyflavone). The substance of the invention to provide a method of optimized parameters sequential processes of dissolution, emulsification, dispersion and lyophilization that results in liposomal quercetin product with proven independent methods liposomal organisation, high stability and pharmacological activity. The high quality of the target product produced by the method claimed ensures the benefits of level and dynamics of integral pharmacological effect in non-clinical study, as compared with liposomal quercetin product produced by the the prototype method.