Abstract: The present invention relates to combination therapy with drugs, such as microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or PI3K inhibitors, with antibodies or immunoconjugates against HLA-DR or Trop-2. Where immunoconjugates are used, they preferably incorporate SN-38 or pro-2PDOX. The immunoconjugate may be administered at a dosage of between 1 mg/kg and 18 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg, more preferably 8 or 10 mg/kg. The combination therapy can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Preferably, the combination therapy has an additive effect on inhibiting tumor growth. Most preferably, the combination therapy has a synergistic effect on inhibiting tumor growth.

Abstract: The present invention discloses a gene delivery system containing a reduction-sensitive shielding system having a targeting function, a preparation method and an application in the field of gene therapy thereof. The gene delivery system is composed of a reduction-sensitive shielding system having a targeting function, cationic polymer material and plasmid DNA; the cationic polymer material and the plasmid DNA complexed to form complex particles, the reduction-sensitive shielding system having a targeting function is shielded on the complex surface by means of electrostatic interaction, so as to reduce the toxicity of the delivery system and successfully transfer the loaded genetic material into cells, thereby achieving expression of genetic material and completing the transfection process, and moreover, improving the targeting and the efficiency of gene transfection.

Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.

Abstract: The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.

Abstract: Provided herein are systems, devices, and methods for ultraviolet (UV) disinfection and sterilization, more specifically, systems, devices, and methods for UV disinfection and sterilization of a container, and more particularly systems, devices, and methods for UV disinfection and sterilization of a container used in the process of fermentation for an alcoholic beverage. Provided are also systems, UV devices, and methods for inhibiting the growth of one or more species of microorganisms present in a container, preferably for inhibiting the growth of one or more species of microorganisms present on an interior surface of a container.

Abstract: Ultraviolet radiation is directed within an area. The target wavelength ranges and/or target intensity ranges of the ultraviolet radiation sources can correspond to at least one of a plurality of selectable operating configurations including a sterilization operating configuration and a preservation operating configuration.

Abstract: The sterilizing tool is configured to wipe debris from and to sterilize and/or dry a working end-site of medical device; using a wiping, twisting, dabbing, push/pull, and/or screwing motion around all of the surface aspects of the device to be sterilized. Additionally, the sterilizing tool is configured to form fit to the surfaces of the end-site and to apply an inclusive layer of an anti-pathogenic agent to the inner and outer surfaces of the working end-site. The sterilizing tool may be frictionally engaged with and retained on the working end-site until removed and the end-site is ready for use. The sterilizing tool is intended for a one time, single use, disposable application.

Abstract: The dispenser can be used with air fresheners including a container (1) holding a perfuming liquid (2) and closed by means of a wooden cap (3), with the particularity that the said wooden cap (3) is provided with a central axial duct (4) of small diameter, communicating with a second transverse duct (5) provided in an upper semi-cylindrical extension (6) and passing through this transverse duct (5), the diffusing string or wick (7) being retained therein and impregnated in perfuming liquid (2) when the container (1) with the cap (3) coupled to the neck (1?) is turned upside down.

Abstract: To provide an illuminating device-cum-air cleaning device that solves a heat problem and allows efficient operation of an air cleaning means. Air inlets/outlets 3A and 3B are provided in a wall surface of a housing 10 to which an illumination light source 2 is attached. A fan 4 is provided in the housing 10 to generate a forced air flow inside and outside the housing 10 through the air inlets/outlets 3A and 3B and discharge heat from the illumination light source 2 by the forced air flow to the outside of the housing 10. In the middle of a flow path for the forced air flow a within the housing 10, a photocatalyst 50 facing the flow path and a UV light source 51 irradiating the photocatalyst 50 with light including ultraviolet rays are provided as air cleaning means 5.

Abstract: The invention relates to a wound care article (100; 200; 300; 400; 500) comprising at least one body (1; 11; 21) absorbing the liquid wound exudates, and at least one shell (2; 12; 22) at least partially encompassing the body (1; 11; 21). The shell (2; 12; 22) itself is designed to absorb fluids.

Abstract: Kit for producing a bone cement paste, comprising a paste A and a paste B; paste A comprising at least one monomer for radical polymerization, at least one peroxide polymerization initiator and at least one tertiary amine, at least one amidine or a mixture of a tertiary amine and amidine; paste B comprising at least one monomer for radical polymerization, at least one heavy metal compound as polymerization accelerator, and as polymerization co-accelerator at least one sulfimide, at least one dicarboxylic acid imide or a mixture thereof, at least one of the pastes A and B comprising at least one filling agent that is insoluble in the monomer of paste A and/or the monomer of paste B.

Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.

Abstract: A bone cement formulation having i) a PMMA powder fraction designed for quick reaction and ii) a polymerization inhibitor provided in a delayed release form. This allows the cement to obtain an initial viscosity suitable for injection and a long working time.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: Polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be used to make orthopedic implants.

Abstract: A porous medical implant and a method of making same is described. The medical implant comprises a porous surface formed by application of pulsed electrical energy ins such a way as to cause a localized heating in the surface of the material comprising portions of the implant. The method comprises a pulsed current sintering technique.

Abstract: A bone patch and method for treating a bone condition of an animal. The bone patch includes a composition of ingredients. The composition of ingredients include: stem cells; signaling molecules for osteoblast/endothelial differentiation; and scaffold material. The method for treating a bone condition includes: applying the bone patch to the animal for bone regeneration, treatment of a fractured bone, and/or treatment of a bone disorder.

Abstract: A device and method for improving hydration of a biomaterial includes a syringe having a cavity therein and a distal opening, an end cap, and a wall operatively coupled to the end cap. The end cap has a distal plate with an inlet and is removably attached to the syringe to cover the distal opening. The wall is positioned proximate to the inlet and at least partially defines a volume in fluid communication with the inlet. An orifice extends through the wall and fluidly connects the volume to the cavity. A flow of a liquid component of biomaterial diffuses through the orifice and is introduced into a particulate component of biomaterial. As such, the liquid component of biomaterial hydrates the particulate component of biomaterial.

Abstract: A plurality of porous metal bodies which are bonded with each other at bonded-boundary surfaces parallel to a first direction, each of the porous metal bodies has a three-dimensional network structure formed from a continuous skeleton in which a plurality of pores are interconnected so as to have a porosity rate different from another porous metal body, the pores formed in at least the porous metal body having the higher porosity rate are formed to have flat shapes which are long along a direction parallel to the bonded-boundary surface and short along a direction orthogonal to the bonded-boundary surface, an entire porosity rate of a bonded body of the porous metal bodies is 50% to 92%, a compressive strength compressing in the direction parallel to the bonded-boundary surface is 1.4 times to 5 times of a compressive strength compressing in the direction orthogonal to the bonded-boundary surface.

Abstract: Porous implant material having a plurality of metal bodies having different porosity rates which are bonded with each other at bonded-boundary surface F parallel to a first direction, wherein: a bonded body of the metal bodies has an entire porosity rate of 50% to 92%; the metal body having higher porosity rate is a porous metal body having a three-dimensional network formed from a continuous skeleton in which a plurality of pores are interconnected; the metal body having lower porosity rate has a porosity rate of 0 to 50% and an area-occupation rate of 0.5% to 50% in a cross-section surface orthogonal to an axial direction which agrees with the first direction along the bonded-boundary surface; and a compressive strength compressing in a direction parallel to the bonded-boundary surface is 1.4 times to 10 times of a compressive strength compressing in a direction orthogonal to the bonded-boundary surface.

Abstract: The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.

Abstract: Methods and compositions are provided for reducing, treating or preventing adhesions in a patient in need of such treatment. In one embodiment, an implantable device is provided for reducing or preventing adhesion formation at a post-operative tissue site in a patient, the implantable device including a biodegradable porous matrix comprising dextran, wherein the implantable device is capable of releasing the dextran over at least 2 days.

Abstract: A medical waste container comprises a bag with a flexible body defining a cavity and having a fill opening. A tube has a closed end in the bag and an opposite open end projecting from the bag. An elastic ring attached to the bag around the fill opening presses against the tube. A lip projects from the tube adjacent its closed end. A tab also projects from the tube, and a discharge opening is formed in the tube between the lip and the tab. A flow path extends from the open end of the tube into the cavity when the elastic ring encircles the tube at a first position between the tab and the open end. The ring slips over the tab from the first position to a second position in which the ring covers the discharge opening as liquid passes through the flow path, adding weight to the bag.

Abstract: A medical device includes a tubular member having a distal end residing interiorly of the body of a patient, a proximal end extending exteriorly of the body, and a lumen extending therebetween. A first passageway extends along the tubular member between a distal end in fluid communication with the lumen, and a proximal end extending exteriorly of the body. A second passageway extends along the tubular member between a distal end located distal to the distal end of the first passageway, and a proximal end extending exteriorly of the body. An occlusion member is associated with the distal end of the second passageway. The occlusion member is movable between an occluded configuration and a non-occluded configuration for selectively occluding the lumen of the tubular member. When the lumen is occluded, a flushing fluid may be passed therethrough via the distal end of the first passageway.

Abstract: A mobile system for separating donor blood by gravitational force into erythrocyte concentrate and plasma. The system includes a first bag serving as a reservoir for the blood to be separated and at least a second and third bag for respectively receiving the erythrocyte concentrate and plasma, and also multiple tubes for connecting the flexible bags to a separator module having a separating membrane in the form of a bundle of hollow fibers. This system is divided into at least one first and one second sterilely packaged, individual subsystem. The first subsystem includes the individual bags and associated connection tubes and the second subsystem includes the separator module, and male/female connectors.

Abstract: An implantable heart assist system, includes a pumping chamber formed of a flexible material and being adapted to be placed in fluid connection with the aorta and a pump system comprising a first rigid member and a spaced apart second rigid member so that at least a portion of the pumping chamber may be positioned therebetween, a drive system comprising a motor. The motor is adapted to cause the second rigid member to move toward the first rigid member to compress the pumping chamber or away from the first rigid member to expand the pumping chamber. A controller is in operative connection with the drive system and controlling the motor.

Abstract: A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.

Abstract: A method is provided for regenerating spent zirconium phosphate for reuse in sorbent dialysis treatments or other re-uses as a sorbent material. The method includes contacting spent zirconium phosphate with an aqueous disinfectant solution having at least one antimicrobial agent, and treating the resulting disinfected zirconium phosphate with an acidic solution to provide a treated zirconium phosphate that can be re-used as a sorbent material. Sorbent cartridge products containing the regenerated spent zirconium phosphate are also provided. Methods and systems for sorbent dialysis which re-use the regenerated zirconium phosphate such as part of sorbent cartridges, additionally are provided.

Abstract: Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled.

Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

Abstract: The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.

Abstract: An intravenous (IV) pole docking system for supporting medical equipment having a mast engaged to a base, the base having legs to support the mast and a lifting mechanism engaged to the base and the mast for moving the base along the mast in combination with an extension arm meant to reduce the IV pole footprint. The boom/IV pole system can reduce excess obstacles in and around hospital bed, surgical rooms and the like.

Abstract: A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Abstract: An infusion system having a priming detection system to indicate that a component of the system, for example a cannula or needle, is primed with a fluid to be delivered into an individual's body. The infusion system utilizes a reactive element that reacts with the fluid or at least one component of the fluid to be delivered, to produce a color change or a colored complex. The reactive element can be deposited, coated or otherwise incorporated in any component of the infusion system that would benefit from a visible indication of a primed fluid, including, but not limited to a tubing, infusion set, cannula, needle and/or guard element at least partially covering or surrounding a cannula or needle. The visual indication improves the user experience during the priming and filling of the system by providing a clear color change confirmation upon priming completion and prior to insertion into the body.

Abstract: A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.

Abstract: An ambulatory infusion device includes a common module having a pump mechanism and a fluid flow path in communication with the pump mechanism. The device also includes a custom module operably coupleable to the common module. The custom module includes a reservoir for housing a liquid composition comprising a medicament and control electronics. The reservoir is configured to fluidly couple with the fluid flow path, and the control electronics are configured to electrically couple to the pump mechanism when the common module and the custom module are operably coupled. When the common module and the custom module are operably coupled, the pump mechanism is configured to drive the liquid composition from the reservoir to a patient via the fluid flow path, and the control electronics are configured to control the rate at which the pump mechanism drives the liquid composition.

Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.

Abstract: A line management apparatus for managing multiple IV lines connected in a Y fitting provides for flow sensing and for electronic control of flow in the multiple lines. The line management apparatus may be used independently as a precise gravity feed IV system or may provide for use in combination with an infusion pump to ensure proper delivery of multiple solutions without blending of the multiple solutions.

Abstract: To detect air in a fluid delivery line of an infusion system, infusion fluid is pumped through a fluid delivery line adjacent to at least one sensor. A signal is transmitted and received using the at least one sensor into and from the fluid delivery line. The at least one sensor is operated, using at least one processor, at a modified frequency which is different than a resonant frequency of the at least one sensor to reduce an amplitude of an output of the signal transmitted from the at least one sensor to a level which is lower than a saturation level of the analog-to-digital converter to avoid over-saturating the analog-to-digital converter. The signal received by the at least one sensor is converted from analog to digital using an analog-to-digital converter. The at least one processor determines whether air is in the fluid delivery line based on the converted digital signal.

Abstract: A syringe shield useful for containing a syringe loaded with radioactive and/or light sensitive drugs is disclosed. The syringe shield may reduce a healthcare provider's exposure to radiation and/or may reduce or eliminate ambient light contamination to optically sensitive components in the syringe.

Abstract: An autoinjector comprising a lower body (10) receiving a tank, said tank containing fluid product and comprising a piston and a needle, such as a pre-primed syringe (A), said autoinjector comprising: injection means (5, 8) to inject said fluid product through said needle when said needle is in an injection position; and a tank movement device (2, 4, 9) for retracting said needle out of the body of the user after injection of the fluid product, a trigger (19), actuated by said injection means, actuating said tank movement device (2, 4, 9) after injection of the fluid product so as to retract said needle; said autoinjector comprising a retarding device (15, 16, 17) adapted to delay during a predetermined time the actuation of said tank movement device (2, 4, 9) by said trigger (19) after injection of the fluid product, to delay retraction of said needle by said predetermined time after the end of injection.

Abstract: An autoinjector includes a housing (10) to receive a syringe (14), and a drive mechanism including first and second springs (30, 32) operating in tandem via an intermediate member (34), on a plunger (42). The plunger is retained in a locked position by a trigger. Release of the trigger causes the first spring to advance the syringe to an arrest point whereafter the second spring extends within the syringe to expel a dose.

Abstract: The invention relates to a method for delivering at least one fluid medicament from a medical device. The invention also relates to a medical device. The technical problem of improving the dose accuracy is solved by a method for delivering at least one fluid medicament from a medical device comprising a first reservoir containing a first fluid medicament, a second reservoir containing a fluid, and a fluid element connected to said first reservoir and said second reservoir. The method comprises receiving information about a desired dose of the first fluid medicament to be ejected, adjusting said dose to be ejected from said first reservoir based at least in part on information about a content of said fluid element, and ejecting said adjusted dose from said first reservoir through said fluid element. The technical problem is further solved by a medical device configured to work according to the method.

Abstract: Disclosed herein is a valve assembly comprising a male luer end portion and a female luer end portion and a passage for the transfer of fluids extending between the male and female luer end portions, valve means movable between a first position, in which the passage is closed, and a second position, in which the passage is open, biasing means for biasing the valve means toward the first position, and actuating means extending into the male luer end portion and coupled to the valve means to actuate the valve means when a female luer end portion of a medical accessory is engaged with the male luer end portion.

Abstract: A syringe for use in a pressurized injection of a fluid includes a syringe barrel including a polymeric material having undergone expansion via blow molding. A preform for blow molding a blow molded syringe is described, the preform including a proximal end having a retention mechanism adapted to connect to the syringe to a powered injector, a distal end having a syringe outlet section, and a barrel section between the retention mechanism and the syringe outlet section, wherein the barrel section is adapted to be blow molded to form a cylindrical wall of a syringe barrel defined between the retention mechanism and the syringe outlet section.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.

Abstract: The present invention provides an antiseptic cap for use with an access site having a housing with a wall defining a chamber, the wall having a set of threads on an inner surface of the wall; and an access site contacting surface associated with the housing having an antiseptic substance for contacting a surface of the access site. The present invention also provides an antiseptic cap equipped plunger assembly wherein an antiseptic cap is retained within a housing of the plunger.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap holder assembly containing a cap and an absorbent material removably attached to the syringe.

Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.