Abstract: Subcutaneous implantation tools and methods of implanting a subcutaneous device using the same. The tool may include a tool body having a longitudinally extending recess having a distal opening and having a tunneler at a distal end of the tool body extending from the distal opening of the recess. The tool may include a plunger slidably fitting within at least a portion of the tool body recess. The recess may be configured to receive an implantable device and the tunneler preferably extends distally from the recess at a position laterally displaced from the device when the device is so located in the recess. Movement of the plunger distally within the recess advances the device distally out of the recess and alongside of and exterior to the tunneler.

Abstract: The invention discloses a method, a system, a computer program and a device for determining the surface charge and/or dipole densities on heart walls. Using the foregoing, a table of dipole densities ?(P?, t) and/or a table of surface charge densities ?(P?, t) of a given heart chamber can be generated.

Abstract: An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.

Abstract: A biological information detection device which detects an arrhythmia on the basis of pulse wave information, performs control on measurement of an electrocardiogram on the basis of the detection result, and thereby restrains failure to record the electrocardiogram at the time of occurrence of an arrhythmia, or the like.

Abstract: The present invention provides a heart murmur detection device. The heart murmur detection device includes: an ECG signal detection unit for detecting an ECG signal from a heart of a user; a heart beat detection unit for detecting the frequency of the ECG signal; a plurality of sound receiving units for receiving a plurality of sound signals from the heart of the user; a signal transforming unit for transforming the sound signals into a plurality of electric phonic signals, and for retrieving the electric phonic signals on the basis of the ECG signal; and a signal processing unit for determining a heart murmur generating position. Moreover, the present invention further provides a heart murmur detection method.

Abstract: A heartbeat detection device includes a peak search unit (4) for searching for one of a peak at which a value M obtained from a sampling data sequence of an electrocardiographic waveform of a living body changes from an increase to a decrease and a peak at which the value M changes from a decrease to an increase, and a heartbeat time determination unit (5) for checking the value M in a predetermined time domain before a time of the peak and the value M in a predetermined time domain after the time of the peak, and setting the time of the peak as a heartbeat time if differences between the value M at the time of the peak and the values M in the predetermined time domains are not smaller than a predetermined amount.

Abstract: An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

Abstract: Example headsets and electrodes are described herein. Example electrode units described herein include a guide defining an opening and an electrode disposed in the opening. The electrode has a housing, a spring, and a pin. The pin is biased outward from a first end of the housing via the first spring. The example electrode units also include a second spring disposed over the opening adjacent a second end of the housing.

Abstract: Example headsets and electrodes are described herein. Example electrode units described herein include a housing defining a cavity, conductive paste disposed on an inner wall of the cavity and an electrode disposed in the cavity and spaced apart from the inner wall of the cavity. The electrode extends from the cavity, and the conductive paste is to shield the electrode from noise.

Abstract: In electrocardiography (ECG) system, a patient cable connecting one or more electrodes to a processing device for processing ECG signals may include one or more electrode connectors mechanically keyed to respective electrodes and/or a device connector mechanically and/or electronically keyed to a cable connector of the processing device. In some embodiments, keying between the cable and electrode is achieved, for example, with an electrode including a hollow-post portion that defines a bore in conjunction with a post protruding from an arm of the electrode connector that is sized to fit within the bore.

Abstract: A wearable apparatus and a method for ECG signal collection includes: a main body, including a first ECG sensor electrode provided on a side of the main body away from a wearing position of an individual and a second ECG sensor electrode provided on a side of the main body close to the wearing position, a securing portion, including a third ECG sensor electrode provided on a side of the securing portion away from the wearing position, and an ECG sensor, provided in the main body and configured to: electrically connect to the first ECG sensor electrode and the second ECG sensor electrode, electrically connect to the third ECG sensor electrode through a wire in the securing portion, and collect ECG signals from close circuits formed by the first ECG sensor electrode, the second ECG sensor electrode, and the third ECG sensor electrode.

Abstract: The invention relates to a medical electrode for recording bioelectrical signals from a muscle, in particular a cardiac muscle, via the skin of a human or animal. The medical electrode comprises: a metal contact (2) for connection to an electrode cable; an electrically conductive electrode plate (3) for receiving the bioelectrical signals; a contact means (4) for establishing an electrical contact between the electrode plate and the skin; and an electronic circuit (7) which comprises a memory (6) for storing electrode-related data.

Abstract: An extended wear electrocardiography patch is provided. An integrated flexible circuit includes a pair of circuit traces that each originate within one end. A pair of electrocardiographic electrodes are each electrically coupled to one of the circuit traces. A layer of adhesive is applied on a contact surface of the flexible circuit and includes an opening on each end. Conductive gel is provided in each of the openings of the adhesive layer and is in electrical contact with the electrocardiographic electrodes. A non-conductive receptacle is adhered on one end of an outward surface of the flexible circuit and is operable to removably receive an electrocardiography monitor. The non-conductive receptacle includes electrode terminals aligned to electrically interface the circuit traces to the electrocardiography monitor. A battery is affixed to the outward surface of the flexible circuit and electrically interfaced via battery leads to a pair of electrical pads.

Abstract: A rise action assistance device according to an aspect of the present disclosure is provided with: a myoelectric potential acquirer that acquires a myoelectric value of a sitting user's tibialis anterior muscle, and a myoelectric value of the sitting user's vastus lateralis muscle or a myoelectric value of the sitting user's vastus medialis muscle; an angle acquirer that acquires a bend angle of the sitting user's upper body; a detector circuit that detects a start of a rise action by the user, based on the myoelectric value of the user's tibialis anterior muscle, the myoelectric value of the user's vastus lateralis muscle or the myoelectric value of the user's vastus medialis muscle, and the bend angle of the user's upper body; and an assistor that starts assistance of the rise action after the start of the rise action is detected.

Abstract: An MR imaging method with an imaging workflow is provided. Within the scope of the MR imaging method, at least one breath-holding command is output to a patient. An MR imaging is performed with an MR imaging method that may be used with free breathing. A breathing movement of the patient is detected based on measured data acquired when performing the MR imaging method. A time relationship is determined between the breathing movement of the patient and the breath-holding command. The imaging workflow is modified as a function of the determined time relationship. A breathing monitoring device and a magnetic resonance imaging system are also provided.

Abstract: The embodiments described herein relate to devices, systems and methods for in-vivo diagnosis of disease-state tissue within a body.

Abstract: Ingestible bio-telemetry communication network and associated systems are described. The communication network can include one or more ingestible bio-telemetry tags; and a reader, wherein each of the one or more ingestible bio-telemetry tags generates an out-link signal comprising, for each bit of data in a frame, a pulse reverse keyed symbol. Multiple ingestible bio-telemetry tags can be managed at the same time by allowing the frequency of the transmit carrier signal to change, or “hop” to different frequencies so as to minimize likelihood of collision. A reader can identify the proper frequency either by a signal from the tags indicated the frequency of the next hop or, when no bi-directional communication is available, by deducing the carrier signal frequency from the start bits of a received frame from the tag and scanning for the shifted carrier signal frequency within a tolerance of the deduced carrier signal frequency.

Abstract: The invention relates to wireless biotelemetry of low level bioelectric and biosensor signals by directly modulating the backscatter of a resonant circuit. Low level electrical analog or digital signals are directly applied to a resonant circuit containing a voltage-variable capacitor such as a varactor diode, that proportionally shifts the resonant frequency and so amplitude of radiofrequency backscatter in a way that represents analog bioelectric or biosensor waveform data. By strongly driving the resonant circuit with a radiofrequency source, a voltage variable capacitance can be caused to amplify the bio-signal level by a parametric process and so provide sufficient sensitivity to telemeter for low millivolt and microvolt level signals without additional amplification. A feature of the device is its simplicity and that it accomplishes both modulation and preamplification of low level sensor signals by the same variable capacitance circuit which reduces the device size and power consumption.

Abstract: A measurement device for a human respiratory system function comprises a respiration measurement device (20). The respiration measurement device (20) receives a respiratory air flow and senses the respiratory air flow to generate a set of sensing signals, and performs calculation according to the sensing signals to generate a human respiratory system parameter, the sensing signals comprising at least an absolute pressure of the respiratory air flow. The respiration measurement device (20) comprises a respiration measurement channel (21). The absolute pressure generated by a respiratory air flow of a user in the respiration measurement channel (21) that is in a single-end sealed state is measured. The absolute pressure corresponds to the pressure in the lung of the user.

Abstract: Automated devices provide methodologies for determining sleep conditions, which may be in conjunction with treatment of sleep disordered breathing by a pressure treatment apparatus such as a continuous positive airway pressure device. Based on a measure of respiratory airflow, respiratory characteristics are extracted to detect arousal conditions, sleep stability, sleep states and/or perform sleep quality assessments. The methodologies may be implemented for data analysis by a specific purpose computer, a monitoring device that measures a respiratory airflow and/or a respiratory treatment apparatus that provides a respiratory treatment regime based on the detected conditions.

Abstract: An apparatus and method for non-invasive and continuous measurement of respiratory chamber volume and associated parameters including respiratory rate, respiratory rhythm, tidal volume, dielectric variability and respiratory congestion. In particular, a non-invasive apparatus and method for determining dynamic and structural physiologic data from a living subject including a change in the spatial configuration of a respiratory chamber, a lung or a lobe of a lung to determine overall respiratory health comprising an ultra wide-band radar system having at least one transmitting and receiving antenna for applying ultra wide-band radio signals to a target area of the subject's anatomy wherein the receiving antenna collects and transmits signal returns from the target area.

Abstract: The present disclosure provides an exercise monitoring device. The exercise monitoring device comprises a sensor module, a processing module, a storage module, and a user interface. The present disclosure also provides a method for estimating maximal oxygen consumption and/or future total exercise time by obtaining a person's physiological data and exercise data. The present disclosure further provides a method for calibrating the future total exercise time by environmental conditions to form an environmental specific total exercise time.

Abstract: Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.

Abstract: This invention is a device that provides feedback controlled pressure output that delivers a highly controlled and accurate air stimulus into the larynx for diagnostic use. The device is designed to be significantly more accurate, safer for the patient, and highly modular for easy future modifications compared to previously available commercial devices.

Abstract: A method and system for provoking gait disorders, such as freezing of gait; usable, for example, for diagnosing and/or treatment thereof. In an exemplary embodiment of the invention, displays of situations calculated to cause freezing of gait are presented to a subject, optionally using virtual reality displays. Optionally or alternatively, incipit freezing of gait is identified using changes in gait parameters, and optionally used to guide attempts at causing freezing of gait. Optionally or alternatively, a portable device is provided which detects incipit freezing of gait and generates a corrective signal to the subject.

Abstract: Low-cost, easy-to-use alignment target generators for aligning a user's own face or eye to a camera or scanner are based on field-of-view visual feedback from a filtered or apertured planar light source. These approaches may be made agnostic to the scanner's operating system or other software. Alternatively, software on the scanner or its host device may create a solid light-colored section of an existing display screen to use as a planar light source. In some embodiments, the planar light source may be the virtual image of an object viewed in a plane mirror.

Abstract: Switchable grounded terminal loads are built into, or otherwise coupled to, connectors on motherboards and control devices. The terminal loads are coupled to the bus termination at the connector when the connector is “stuffed” (connected to a mating connector). The switchable grounded terminal loads replace dummy connectors in preventing empty “unstuffed” connectors from increasing error risks on active channels.

Abstract: A muscle fatigue monitoring system includes an sEMG amplifier module configured to receive sEMG signals and amplify the received sEMG signals; a filter module connected with the sEMG amplifier module; a bit-stream converter connected with the filter module and configured to digitize the sEMG signals and convert the sEMG signals to a discrete signal based on a single threshold without digitizing the complete sEMG signals, and a bit-stream cross correlator connected with the bit-stream converter, the bit-stream cross correlator including a plurality of correlation stages connected in series, a plurality of counters connected with the correlation stages respectively, and a maximum value selector connected to the counters, and configured to continuously correlate the sEMG signals in a given time window, count all time instances where the sEMG signals are the same, compares all the counters in cycles, and find distance between specific reference points on the sEMG signals through the counter with a maximum value.

Abstract: A system and method for posture feedback can include collecting kinematic data by an activity monitoring device coupled to a user; calibrating the kinematic data to a base walking orientation of the activity monitoring device, which comprises: detecting a walking activity state through the kinematic data, and when a walking activity state is detected, generating the base walking orientation from kinematic data; setting a posture correction factor; measuring user posture with the calibrated kinematic data; triggering posture feedback based on the user posture adjusted by the posture correction factor.

Abstract: A method, system and apparatus for image capture and registration are described. The method includes: obtaining a position of an imaging device in a tracking system frame of reference; obtaining a position of a patient in the tracking system frame of reference; determining, based on the position of the imaging device and the position of the patient, a transformation for registering an imaging device frame of reference with a patient frame of reference; receiving an instruction to capture an image, the instruction including coordinates identifying a target area in the patient frame of reference; applying the transformation to convert the coordinates to the imaging device frame of reference; and controlling the imaging device to capture an image based on the converted coordinates.

Abstract: In some embodiments, a microelectronic sensor includes an open-gate pseudo-conductive high-electron mobility transistor and used for biometric authentication of a user. The transistor comprises a substrate, on which a multilayer hetero-junction structure is deposited. This hetero-junction structure comprises a buffer layer and a barrier layer, both grown from III-V single-crystalline or polycrystalline semiconductor materials. A two-dimensional electron gas (2DEG) conducting channel is formed at the interface between the buffer and barrier layers and provides electron current in the system between source and drain electrodes. The source and drain contacts, which maybe either ohmic or non-ohmic (capacitively-coupled), are connected to the formed 2DEG channel and to electrical metallizations, the latter are placed on top of the transistor and connect it to the sensor system.

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.

Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: An eye-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the eye-mountable device, and the transparent polymer has a concave surface and a convex surface. The structure includes a substrate, an antenna comprising a conductive loop, and a sensor that is configured to detect an analyte. The substrate includes a loop portion and a tab portion, where the loop portion has an outer circumference defined by an outer diameter and an inner circumference defined by an inner diameter, and where the tab portion extends from the inner circumference of the loop portion towards a center of the loop portion. The conductive loop is disposed on the loop portion of the substrate between the inner circumference and outer circumference, and the sensor is disposed on the tab portion of the substrate.

Abstract: A concentration measurement apparatus includes a probe, having a light incidence section making measurement light incident on the head and a light detection section detecting the measurement light that has propagated through the interior of the head, and a CPU determining temporal relative change amounts of oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration and determining a correlation coefficient of the relative change amounts and a polarity of a slope of a regression line.

Abstract: A system and method that enables a person to unobtrusively assess their cognitive function from mobile device usage. The method records on the mobile device the occurrence and timing of user events comprising the opening and closing of applications resident on the device, the characters inputted, touch-screen gestures made, and voice inputs used on those applications, performs the step of learning a function mapping from the mobile device recordings to measurements of cognitive function that uses a loss function to determine relevant features in the recording, identifies a set of optimal weights that produce a minimum of the loss function, creates a function mapping using the optimal weights, and performs the step of applying the learned function mapping to a new recording on the mobile device to compute new cognitive function values.

Abstract: A system and method that enables a person to unobtrusively quantify the effect of mobility, physical activity, learning, social interaction and diet on cognitive function.

Abstract: A method for detecting and presenting burnout symptoms associated with users is provided. The method may include receiving a plurality of predictor rules for monitoring and detecting a plurality of burnout indicators. The method may further include monitoring and receiving the plurality of burnout indicators. Additionally, the method may include storing the monitored and received plurality of burnout indicators. The method may also include detecting a plurality of burnout events associated with the stored monitored and received plurality of burnout indicators. The method may further include determining the plurality of burnout symptoms based on the detected plurality of burnout events. The method may also include determining at least one aggregate score based on the determined plurality of burnout symptoms. The method may further include presenting at least one alert and at least one recommendation based on the determined plurality of burnout symptoms and the determined at least one aggregate score.

Abstract: The personality assessment and treatment determination system includes a facial recognition device for imaging a patient's face and receiving demographic and personality information from the patient, and a micro-lab device positioned in communication with the facial recognition device. The micro-lab device includes a body having at least one slot configured for receiving a slide holding the patient's bodily fluid, a scanner for analyzing the patient's bodily fluid, and a selector switch for selecting the bodily fluid to be analyzed. The information from the facial recognition device, each of the plurality of questionnaires, and from the micro-lab device is combined to determine the patient's psychological disorder and a to treatment for the patient's psychological disorder.

Abstract: A wearable ultrasound device for signalling changes in human or animal body, and use of such a wearable device for signalling over a prolonged period of time. In an example the changes occur in a bladder. Such is especially relevant for elderly persons, women after delivery of a baby, lesion patients, demented people, children, and others, have a difficulty to control functioning of the bladder, and to be at the toilet on time to urinate.

Abstract: The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a tool to screen, detect, diagnose and/or monitor relative olfactory deterioration resulting from Alzheimer's disease. A preferred embodiment comprises cascading aromas by serially administering more than one pure odorant to the patient's nostrils, left vs right, with measurement of the time, or numbers of breaths, required to cognitively notice the pure odorants' presence.

Abstract: Devices and methods for measuring balance in a subject are described herein. The devices include a platform, a mechanism connected to the platform, and at least one sensor in or on the platform. The at least one sensor measures the balance of a subject atop the platform as the mechanism induces a platform movement in the horizontal plane. A data set measured by the at least one sensor can processed and then used to assess a subject's balance.

Abstract: Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, PTSD, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition.

Abstract: Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject.

Abstract: A method of image-based quantification for allergen skin reaction includes imaging an area of skin that has been subject to a skin-prick test to produce one or more images of the area. The method includes identifying regions of wheal and/or flare in the one or more images of the area and quantifying weal and/or flare indicators based on the regions identified. The method also includes outputting results of the quantified wheal and/or flare indicators indicative of quantified allergen skin reaction.

Abstract: Apparatus and processes for use in a narrow body lumen are provided. Apparatus may include an outer shaft portion; a tube receivable within the outer shaft portion; and an elongate inflatable body having first and second ends, the first end being sealed to the outer shaft portion and the second end being sealed to the tube. In an initial configuration, the elongate inflatable body is received in the outer shaft portion. The tube is slidable relative to the outer shaft portion to evert the elongate inflatable body when the elongate inflatable body moves out of the outer shaft portion.

Abstract: An image display control apparatus includes: an image obtaining unit that obtains an image of a backbone region that includes at least a portion of the backbone of a subject; an emphasized display target region specifying unit that specifies an emphasized display target region within the backbone region based on the image; a bone metastasis region specifying unit that specifies an osteolytic metastasis region included in the backbone region; and a display control unit that causes images to be displayed by a display unit. The display control unit displays an osteolytic metastasis region that belongs within the emphasized display target region with a greater degree of emphasis than an osteolytic metastasis region outside the emphasized display target region.

Abstract: A method for providing feedback during ligament insertion in knee joint orthopedic surgeries includes providing an imaging device providing knee joint articular surface geometry data, providing a position measuring device providing distal ligament insertion sites, providing a strain measuring device providing ligament reference strain, providing a drive system providing a prescribed kinematic path for the knee joint and providing an adaptive migration application. The adaptive migration application receives inputs including the knee joint articular surface geometry data, the distal ligament insertion sites, the ligament reference strain and the prescribed kinematic path for the knee joint and generates outputs including sets of isotonic, hypertonic and hypotonic points representing proximal insertion sites of a ligament fiber associated with prescribed distal ligament insertion sites.

Abstract: Disclosed is a postprandial glucose-measuring device for preventing the development of or reversing T2D. Included are methods for using the device as well as better use for invasive and noninvasive glucose meters. Further disclosed are novel exercise-sensitizing compositions useful for managing blood glucose levels in Type-2 diabetics with minimal risk of hypoglycemia. The disclosed glucose meters allow a user to also measure exercise and meal size—all with relatively instant feedback—more effectively than having to track the complexity posed by labels, glycemic index and calories. Also disclosed is integration of glucose-measuring devices with smartphones and health monitoring technology to make possible safe and effective interpretation of postprandial glucose readings by a patient to control or reverse Type-2 diabetes.