Patents Issued in September 21, 2017
  • METHOD FOR PRODUCING ASTROCYTES
    Publication number: 20170267971
    Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
    Type: Application
    Filed: August 13, 2015
    Publication date: September 21, 2017
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Baek Soo Han, Sang Chul Lee, Kwang-Hee Bae, Cheonok Lee, Won Kon Kim, Kyoung Jin Oh
  • PRODUCTION METHOD FOR PLURIPOTENT STEM CELLS HAVING ANTIGEN-SPECIFIC T CELL RECEPTOR GENE
    Publication number: 20170267972
    Abstract: Provided is a method for inducing T cells for use in a cell-based immunotherapy, comprising the steps of: (1) providing human pluripotent stem cells bearing a T cell receptor specific for a WT1 antigen or an Epstein-Barr virus associated antigen, and (2) inducing T cell progenitors or mature T cells from the pluripotent stem cells provided in step (1). Pluripotent stem cells may preferably be iPS cells. The human pluripotent stem cells bearing a T cell receptor specific for an antigen may be prepared by inducing iPS cells from a T cell having the desired antigen specificity or by introducing genes encoding the T cell receptor specific for the desired antigen into iPS cells. The T cells obtained by this method can be used for the treatment of various immune-related diseases such as cancers and infectious diseases.
    Type: Application
    Filed: July 17, 2015
    Publication date: September 21, 2017
    Inventor: Hiroshi Kawamoto
  • METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
    Publication number: 20170267973
    Abstract: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
    Type: Application
    Filed: December 30, 2016
    Publication date: September 21, 2017
    Inventors: Juan F. Vera, Cliona M. Rooney, Ann M. Leen, John R. Wilson
  • EX VIVO DEVELOPMENT, EXPANSION AND IN VIVO ANALYSIS OF A NOVEL LINEAGE OF DENDRITIC CELLS
    Publication number: 20170267974
    Abstract: Disclosed herein are new methods of producing a novel line of dendritic cells. The method comprises subjecting a sample of hematopoietic stem/precursor cells to a first feeder culture system that is supplemented with a first set of factors and a second feeder culture system supplemented with a second group of factors. The disclosure also pertains to new cell types that may be used as cancer immunotherapy.
    Type: Application
    Filed: October 24, 2016
    Publication date: September 21, 2017
    Inventor: Lung-Ji Chang
  • THREE-DIMENSIONAL CULTURE STRUCTURE AND METHOD FOR PRODUCING SAME
    Publication number: 20170267975
    Abstract: Provided is a three-dimensional culture structure that is excellent in cell adhesion and cell stretching and can be produced efficiently. The three-dimensional culture structure includes cells, a cell support material configured to support the cells, and bioaffinity particles. In a preferable mode, the bioaffinity particles are exposed from at least part of the surface of the cell support material, or the bioaffinity particles are protruded from the cell support material, or a surface area occupation rate at which the bioaffinity particles are exposed is 20% or greater of the entire surface of the three-dimensional culture structure, or the bioaffinity particles are dispersed in the cell support material.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Applicant: RICOH COMPANY, LTD.
    Inventors: Aino Hasegawa, Daisuke Takagi, Shigeo Hatada, Yuuma Usui, Chihiro Kubo, Shusaku Shiomoto, Waka Lin
  • MEDICAL APPARATUS FOR TRANSFERRING FLUIDS
    Publication number: 20170267976
    Abstract: A mask is included. The mask includes: a tubing portion having a fastener portion; and a face receptacle portion having a valve portion. The face receptacle portion is coupled to the tubing portion for facilitating the transfer of one or more fluids to a patient. The face receptacle has a semi-filled shape.
    Type: Application
    Filed: May 27, 2017
    Publication date: September 21, 2017
    Inventor: Jennifer Dawn Antoine
  • ORGANOIDS FOR DRUG SCREENING AND PERSONALIZED MEDICINE
    Publication number: 20170267977
    Abstract: There is provided herein cell culture mediums for generating organoids, including tumour organoids.
    Type: Application
    Filed: July 30, 2015
    Publication date: September 21, 2017
    Inventors: Ling HUANG, Senthil MUTHUSWAMY
  • INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170267978
    Abstract: Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
    Type: Application
    Filed: January 11, 2017
    Publication date: September 21, 2017
    Inventors: Nobuaki Kikyo, Hiroyuki Hirai
  • METHODS AND PRODUCTS FOR TRANSFECTION
    Publication number: 20170267979
    Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Inventors: Matthew Angel, Christopher Rohde
  • Xyloglucan Endotransglycosylase variants and Polynucleotides Encoding Same
    Publication number: 20170267980
    Abstract: The present invention relates to xyloglucan endotransglycosylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: August 20, 2015
    Publication date: September 21, 2017
    Applicant: Novozymes A/S
    Inventor: Daniel Held
  • COMPOSITIONS AND METHODS COMPRISING THE USE OF A BACILLUS AGARADHAERENS INULOSUCRASE (INUO)
    Publication number: 20170267981
    Abstract: Bacillus agaradhaerens strain WDG185 expresses an inulosucrase that efficiently synthesizes a broad range of IOS with a GF range of GF3-GF30. The isolated and/or purified inulosucrase, recombinantly engineered variants thereof, active fragments thereof, synthetic nucleic acids encoding the inulosucrase, its variants, or its active fragments, host cells comprising the synthetic nucleic acids, and compositions comprising the inulosucrase are provided. Methods of using the compositions include the manufacture of inulooligosaccharides.
    Type: Application
    Filed: December 4, 2015
    Publication date: September 21, 2017
    Applicant: DANISCO US INC.
    Inventors: Slavko KRALJ, Marc KOLKMAN, Chris LEEFLANG, Johannes G. DE NOBEL, Arjen HOEKSTRA, Veil ALKAN
  • POLYMERASE COMPOSITIONS AND USES
    Publication number: 20170267982
    Abstract: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.
    Type: Application
    Filed: February 1, 2017
    Publication date: September 21, 2017
    Applicant: Thermo Fisher Scientific Baltics UAB
    Inventors: Arunas Lagunavicius, Arvydas Janulaitis
  • Exonuclease Deficient Polymerases
    Publication number: 20170267983
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Application
    Filed: February 27, 2017
    Publication date: September 21, 2017
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • CHLOROPHYLLASE OVERPRODUCTION TO ENHANCE PHOTOSYNTHETIC EFFICIENCY
    Publication number: 20170267984
    Abstract: Recombinant microorganisms and methods for using the same are disclosed herein for producing biomass or at least one biomolecule. These methods comprise culturing a photosynthetic microorganism that can overexpress a chlorophyllase, and optionally isolating biomass and/or at least one biomolecule from the culture.
    Type: Application
    Filed: March 9, 2017
    Publication date: September 21, 2017
    Inventors: Kelsey M. McNeely, Joseph C. Weissman
  • MUTANT LACTOBACILLUS BETA-GLUCURONIDASE ENZYMES WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20170267985
    Abstract: Mutated Lactobacillus brevis strain 269Y ?-glucuronidase enzymes with enhanced enzymatic activity at low pH (e.g., below pH 6.8), as well as enhanced thermostability as compared to wild type enzyme are provided. The enzymes of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs at low pH and in 30 minutes or less, as compared to the several hours needed using prior enzyme preparations. Methods of using the mutated enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.
    Type: Application
    Filed: March 21, 2016
    Publication date: September 21, 2017
    Inventors: Jia YANG, Gary Horvath, Pongkwan Sitasuwan, Margarita Marinova, Qian Wang, Lim Andrew Lee
  • GENERATION OF MANNOSE-6-PHOSPHATE CONTAINING RECOMBINANT ALPHA-N-ACETYL GLUCOSAMINIDASE
    Publication number: 20170267986
    Abstract: A method of producing mannose-6-phosphate (M6P)-containing recombinant alpha-N-acetyl-glucosaminidase (Naglu), including the steps of providing a high mannose containing recombinant Naglu protein; and contacting the high mannose containing recombinant Naglu protein with N-acetyl-glucosamine-1-phosphotransferase (GNPT) under conditions that permit phosphorylation of one or more mannose residues on the recombinant Naglu protein, thereby generating M6P-containing recombinant Naglu. A mannose-6-phosphate (M6P)-containing recombinant alpha-N-acetyl-glucosaminidase (Naglu) protein produced by this method, a composition comprising such Naglu protein, and a method of treating Sanfilippo Syndrome Type B (MPS IIIB) including administering to a subject in need of treatment this composition.
    Type: Application
    Filed: June 25, 2015
    Publication date: September 21, 2017
    Inventors: Bohong ZHANG, Michael F. CONCINO, Angela W. NORTON, Muthuraman MEIYAPPAN, Dianna LUNDBERG
  • PLANT LECTINS AS CARRIERS OF ASSOCIATED DRUG SUBSTANCES INTO ANIMAL AND HUMAN CELLS
    Publication number: 20170267987
    Abstract: The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (B subunits) of plant “AB toxins” (PTB lectins) as delivery vehicles for mobilizing associated drug substances for delivery to animal and human cells. The resulting protein fusions or conjugates retain lectin carbohydrate specificity for binding to cells and cellular trafficking activity so as to deliver an associated drug compound to the site of disease manifestation. One embodiment of this invention concerns the ability of ricin toxin B subunit, as a model PTB lectin, to deliver enzyme replacement therapeutic drugs to cells of several organs of the body including the brain and central nervous system, eyes, ears, lungs, bone, heart, kidney, liver, and spleen for treating lysosomal diseases.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 21, 2017
    Inventor: DAVID N. RADIN
  • LUCILIA SERICATA COLLAGENASE
    Publication number: 20170267988
    Abstract: One complementary DNA (cDNA) encodes a collagenase enzyme of Lucilia sericata that includes an identified sequence. Optionally, the cDNA is applied to wound healing.
    Type: Application
    Filed: January 19, 2017
    Publication date: September 21, 2017
    Inventors: Hamzeh Alipour, Abbasali Raz, Navid Dinparast Djadid, Sedigheh Zakeri
  • Method of Production of Rare Disaccharides
    Publication number: 20170267989
    Abstract: The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Inventors: Samir Kumar Roy, Saravanakumar Iyappan, Saju Varghese, Aparna Devi Addala, Milky Agarwal, Kanumuru Rahul Raju, Banibrata Pandey
  • HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES
    Publication number: 20170267990
    Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
    Type: Application
    Filed: January 25, 2017
    Publication date: September 21, 2017
    Inventors: Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
  • ACOUSTOPHORETIC CLARIFICATION OF PARTICLE-LADEN NON-FLOWING FLUIDS
    Publication number: 20170267991
    Abstract: Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
    Type: Application
    Filed: May 5, 2017
    Publication date: September 21, 2017
    Inventors: Bart Lipkens, Walter M. Presz, JR., Kedar Chitale, Daniel Hatten, Nathaniel Bodnar, Goutam Ghoshal
  • Acoustophoretic Device for Angled Wave Particle Deflection
    Publication number: 20170267992
    Abstract: Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
    Type: Application
    Filed: June 5, 2017
    Publication date: September 21, 2017
    Inventors: Bart Lipkens, Walter M. Presz, JR., Kedar Chitale, Thomas J. Kennedy, III, Ben Ross-Johnsrud
  • DIRECTED EVOLUTION USING TURBIDOSTAT FOR INCREASED SPECIFIC GROWTH RATE AND REDUCED LIGHT-HARVESTING ANTENNA SIZE OF PHOTOSYNTHETIC MICROORGANISMS FOR INCREASED PHOTOSYNTHETIC EFFICIENCY
    Publication number: 20170267993
    Abstract: Methods are provided to select strains of photosynthetic microorganisms for enhanced photosynthetic efficiency or biomass accumulation. Strains are mutagenized, and then grown under high light in a turbidostat. Microorganisms created by this process are also described, as well as methods of using such isolated microorganisms for biomass production.
    Type: Application
    Filed: March 9, 2017
    Publication date: September 21, 2017
    Inventors: Joseph C. Weissman, Kelsey M. McNeely
  • Vaccine for Livestock Production Systems
    Publication number: 20170267994
    Abstract: The invention relates to a live vaccine for protection against enteric bacterial infection.
    Type: Application
    Filed: August 28, 2015
    Publication date: September 21, 2017
    Inventors: Mahan Michael, Douglas Heithoff
  • Suspension Container for Binding Particles for the Isolation of Biological Material
    Publication number: 20170267995
    Abstract: A device, method and system is provided for binding particles for the separation and/or isolation of biological materials. In particular, a container is provided including a suspension of binding particles for the isolation of biological material, inner walls forming an elongate groove at the bottom of said container, and a cover having openings and/or being penetrable for a linear arrangement of multiple pipets or pipet tips, said openings being located above and parallel to said elongate groove.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Applicant: Roche Molecular System, Inc.
    Inventors: Geza Burghardt, Willem Mulder, Rolf Schneebeli
  • Sample Processing Devices, Systems and Methods
    Publication number: 20170267996
    Abstract: This instant disclosure provides methods of processing a sample in an automated sample processing device including devices configured for the automated extraction or isolation of nucleic acids. Also provided are plungers for use in such devices and methods of sample processing. Systems for performing the described methods and employing the described plungers are also provided.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Mark Talmer, Jody L. Keck, Wesley W. Addison, II
  • HIGH-THROUGHPUT ASSEMBLY OF GENETIC ELEMENTS
    Publication number: 20170267997
    Abstract: Disclosed is a method of generating a set of sequence-verified nucleic acid elements for the combinatorial construction of genetic elements. The method includes: providing a plurality of nucleic acid parts; assembling nucleic acid parts to form a one or more nucleic acid elements, wherein the nucleic acid elements include at least two sequences selected from the plurality of parts; and determining the sequence of the nucleic acid elements. Further disclosed is pool of higher-order nucleic acid constructs or amplification products thereof, comprising one or more nucleic acid elements as well as kits including a the pool of sequence-verified nucleic acid elements of claims and/or a pool of higher-order nucleic acid constructs; and a plurality of primers for retrieving one or more sequence-verified nucleic acid elements and/or higher-order nucleic acid constructs.
    Type: Application
    Filed: May 27, 2015
    Publication date: September 21, 2017
    Inventors: Robert NICOL, Lauren WOODRUFF, Tarjei MIKKELSEN, Christopher VOIGT
  • METHODS OF SYNTHESIZING POLYNUCLEOTIDES
    Publication number: 20170267998
    Abstract: The present invention is directed to compositions and methods for producing one or more polynucleotides from smaller oligonucleotide segments within an emulsion. In methods of the present invention, a support having one or more capture oligo-nucleotides is contacted with two or more corresponding tile oligonucleotides. Upon hybridization of the tile oligonucleotides to the capture oligonucleotides, a capture complex is formed. This capture complex is emulsified, optionally with reaction reagents or other additives. The emulsion is then incubated at a temperature regimen sufficient for an adjoining extension reaction to occur, such that a polynucleotide may be formed from the tile oligonucleotides that hybridized to a particular support. A particular advantage of this method is that many different polynucleotides may be produced in parallel with surprising efficiency.
    Type: Application
    Filed: December 3, 2015
    Publication date: September 21, 2017
    Inventor: Michael WEINER
  • SYNTHESIS OF SEQUENCE-VERIFIED NUCLEIC ACIDS
    Publication number: 20170267999
    Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.
    Type: Application
    Filed: March 21, 2017
    Publication date: September 21, 2017
    Inventors: Peer F. STAEHLER, Raphael CARAPITO, Cord F. STAEHLER, Mark MATZAS, Jack T. LEONARD, Joachim JAEGER, Markus BEIER
  • ANTISENSE COMPOUNDS AND USES THEREOF
    Publication number: 20170268000
    Abstract: The present invention provides compounds comprising oligonucleotides complementary to a CLN3 transcript. Certain such compounds are useful for hybridizing to a CLN3 transcript, including but not limited to a CLN3 transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the CLN3 transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with Batten Disease.
    Type: Application
    Filed: December 2, 2014
    Publication date: September 21, 2017
    Applicants: Ionis Pharmaceuticals, Inc., Rosalind Franklin University of Medicine and Science
    Inventors: Frank RIGO, Michelle L. HASTINGS
  • RNAS WITH TUMOR RADIO/CHEMO-SENSITIZING AND IMMUNOMODULATORY PROPERTIES AND METHODS OF THEIR PREPARATION AND APPLICATION
    Publication number: 20170268001
    Abstract: Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Nikolai N. Khodarev, Diana Rose E. Ranoa, Sean P. Pitroda, Ralph R. Weichselbaum
  • OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS
    Publication number: 20170268002
    Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
    Type: Application
    Filed: April 4, 2017
    Publication date: September 21, 2017
    Applicant: Regulus Therapeutics Inc.
    Inventors: Christine Esau, Bridget Lollo, C. Frank Bennett, Susan M. Freier, Richard H. Griffey, Brenda F. Baker, Timothy A. Vickers, Eric G. Marcusson, Erich Koller, Eric E. Swayze, Ravi Jain, Balkrishen Bhat, Eigen Peralta
  • Methods of Inducing Exon Skipping
    Publication number: 20170268003
    Abstract: Methods for inducing skipping of exons, including exon 51 of the dystrophin gene. Oligonucleotides are used for inducing exon skipping and for treating Duchenne Muscular Dystrophy. Disclosed structures include: (1) h51AON1 (SEQ ID NO: 27; UCAA GGAA GAUG GCAU UUCU), which is 20 bases long, (2) h51AON2 (SEQ ID NO: 28; CCUC UGUG AUUU UAUA ACUU GAU), which is 23 bases long, and (3) the combination of h51AON2 and h45AON5 linked by 10 uracils (i.e., SEQ ID NO: 28 (CCUC UGUG AUUU UAUA ACUU GAU) linked to SEQ ID NO: 16 (GCCC AAUG CCAU CCUG G) by UUUU UUUU UU), which combination is 50 bases long.
    Type: Application
    Filed: April 5, 2017
    Publication date: September 21, 2017
    Inventor: Judith C. T. Van DEUTEKOM
  • MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
    Publication number: 20170268004
    Abstract: Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Adam Mullick, Rosanne M. Crooke, Mark J. Graham, Kenneth W. Dobie, Thomas A. Bell, III, Richard Lee
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170268005
    Abstract: The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 21, 2017
    Inventors: Kevin Fitzgerald, James Butler, Brian Bettencourt, Anna Borodovsky, Satyanarayana Kuchimanchi, Klaus Charisse, Muthiah Manoharan, Martin Maier, Kallanthottathil G. Rajeev, Donald Foster
  • TOLL-LIKE RECEPTOR 9 ANTAGONIST AND METHODS OF USE THEREOF
    Publication number: 20170268006
    Abstract: The invention provides antagonist of TLR9 and methods of use thereof. These compounds inhibit or suppress TLR9-mediated signaling. The methods may have use in the prevention and treatment of diseases or disorders mediated by TLR9.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Inventors: Sudhir Agrawal, Daqing Wang, Fu-Gang Zhu
  • 5'-TRIPHOSPHATE OLIGORIBONUCLEOTIDES
    Publication number: 20170268007
    Abstract: Disclosed herein are synthetic oligoribonucleotides that form hairpin loop structures. The oligoribonucleotides can be used in the treatment of viral infection including prophylactic treatments. The oligoribonucleotides can also be used as adjuvants.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventor: John Hiscott
  • DIAGNOSTIC AND THERAPEUTIC TARGETING OF DNMT-1 ASSOCIATED RNA IN HUMAN CANCER
    Publication number: 20170268008
    Abstract: A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in the cancer cells of the subject. Embodiments described herein relate to RNAs (e.g., IncRNAs) associated with DNA methyltransferase 1 (DNMTI-associated RNA) in human cancer cells, methods and compositions of modulating the levels of DNMTI-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in cancer cells of the subject to treat cancer cells or a subject in need thereof, and/or methods of measuring the expression profile of DNMT1 associated RNA to determine whether the subject has cancer or an increased risk of cancer and/or the efficacy of a therapeutic regimen agent.
    Type: Application
    Filed: November 24, 2015
    Publication date: September 21, 2017
    Inventors: Ahmed Khalil, Sanford Markowitz
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS
    Publication number: 20170268009
    Abstract: The present invention relates to a method and compositions for the treatment of cystic fibrosis.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 21, 2017
    Inventor: Magali TAULAN-CADARS
  • Biosynthesis Of Human Milk Oligosaccharides In Engineered Bacteria
    Publication number: 20170268010
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: February 24, 2017
    Publication date: September 21, 2017
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • rDNA NTS-BASED GENE MULTIPLE INSERTION CASSETTE SET AND GRAS-GRADE RECOMBINANT YEAST STRAIN
    Publication number: 20170268011
    Abstract: Disclosed is a gene multiple insertion cassette set including rDNA NTS fragments and an auxotrophic selection marker having an incomplete promoter is developed, and a safe oral recombinant strain having no antibiotic resistant marker is constructed by multiple insertion of an optimum number of the developed gene multiple insertion cassette sets into chromosomes of a Saccharomyces cerevisiae strain, a vaccine composition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or nodavirus capsid protein (NNVcp) isolated and purified therefrom, and a composition for feed addition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or squalene or oxidosqualene isolated and purified therefrom.
    Type: Application
    Filed: December 30, 2014
    Publication date: September 21, 2017
    Applicant: CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION
    Inventors: Hyun Ah KANG, Hye Yun MOON, Hong Jin KIM
  • PENTOSE SUGAR FERMENTING CELL
    Publication number: 20170268012
    Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
    Type: Application
    Filed: June 2, 2017
    Publication date: September 21, 2017
    Inventors: Paul KLAASSEN, Gijsberdina Pieternella Van Suylekom, Rene Marcel De Jong
  • VECTOR CONTAINING CENTROMERE DNA SEQUENCE AND USE THEREOF
    Publication number: 20170268013
    Abstract: A vector includes a nucleotide sequence according to any one of the following (a) to (d): (a) a nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21; (b) a nucleotide sequence of a nucleic acid that hybridizes with a nucleic acid consisting of a nucleotide sequence complementary to the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21, under stringent conditions; (c) a nucleotide sequence having 85% or more sequence identity with the nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21; (d) a nucleotide sequence set forth in SEQ ID NO: 12, 15, 18, or 21 in which one or more nucleotides are substituted, deleted, inserted, and/or added.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Applicant: Kaneka Corporation
    Inventors: Teruyuki Nishi, Tozo Nishiyama, Toru Watanabe, Yuji Okubo
  • REGULATORY NUCLEIC ACIDS AND METHODS OF USE
    Publication number: 20170268014
    Abstract: The present invention relates generally to the field of molecular biology and describes nucleic acids encoding regulatory elements capable of affecting expression of a coding sequence. The regulatory elements described herein may be used to direct the expression of a heterologous coding region in the green tissues and upon exposure to light in plants. The invention may also be used to create transgenic plants having improved characteristics, such as yield.
    Type: Application
    Filed: December 8, 2015
    Publication date: September 21, 2017
    Applicant: Syngenta Participations AG
    Inventor: Michael L. NUCCIO
  • PRODUCTION OF PROTEINS IN LABYRINTHULOMYCETES
    Publication number: 20170268015
    Abstract: The present invention provides recombinant host cells that produce proteins or therapeutic proteins, and nucleic acid constructs for producing the cells. The cells have nucleic acid constructs that encode a heterologous protein, for example an antibody. The nucleic acid constructs also can have a functional signal sequence that directs the secretion of the protein from the cell. The signal sequence can be any functional signal sequence, and various signal sequences are disclosed herein. The invention also provides methods of producing the proteins.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Nicky C. Caiazza, Jun Urano, Maung N. Win, Kent S. Boles
  • GENETIC LOCI ASSOCIATED WITH RESPONSE TO ABIOTIC STRESS
    Publication number: 20170268016
    Abstract: Compositions and methods useful in identifying and counter-selecting maize plants with having enhanced yield-related traits relative to control plants under abiotic stress conditions such as salt stress and/or drought are provided herein. The methods use molecular genetic markers to identify, select and/or construct salt stress tolerant and/or drought tolerant maize plants. Also provided are methods to enhance tolerance to salt stress and/or drought in crop plants by transforming crop plants with the Zea mays antiporter/sodium ion transporter or by introducing favorable allelic variants of the Zea mays antiporter/sodium ion transporter gene via gene editing.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 21, 2017
    Inventors: Jennifer S. Jaqueth, Bailin Li, Zhizeng Liu
  • PLANTS AND METHODS TO IMPROVE AGRONOMIC CHARACTERISTICS UNDER ABIOTICSTRESS CONDITIONS
    Publication number: 20170268017
    Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for conferring improved drought tolerance; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are disclosed. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.
    Type: Application
    Filed: July 2, 2015
    Publication date: September 21, 2017
    Inventors: GUIHUA LU, YANG GAO, MIN LIU, JUNHUA LIU, GUANFAN MAO, GHANGGUI WANG, WEI WANG, XIPING WANG
  • Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits
    Publication number: 20170268018
    Abstract: This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Applicant: Monsanto Technology LLC
    Inventors: Charles DIETRICH, Stanislaw FLASINSKI, Liang GUO, Zhaolong LI, Bo-Xing QIU, Wei WU
  • METHODS AND COMPOSITIONS FOR PREVENTING OR REDUCING INFECTIONS OF CROP PLANTS BY BACTERIAL AND FUNGAL PATHOGENS
    Publication number: 20170268019
    Abstract: The present invention teaches methods and compositions useful for treating, preventing, or curing pathogen infections of living plants. In particular, the present invention teaches methods of enhancing plant response to pathogen-associated molecular patterns. The methods and compositions described herein are effective at treating biotrophic pathogens, including Liberibacters.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 21, 2017
    Inventors: Dean W. GABRIEL, Shujian ZHANG
  • MULTIGENOME RETROVIRAL VECTOR PREPARATIONS AND METHODS AND SYSTEMS FOR PRODUCING AND USING SAME
    Publication number: 20170268020
    Abstract: The present invention provides novel multigenome retroviral vectors, methods and packaging systems for making such retroviral vectors and methods of use.
    Type: Application
    Filed: February 22, 2017
    Publication date: September 21, 2017
    Applicant: IMMUNE DESIGN CORP.
    Inventors: Jan Henrik Ter Meulen, Peter Lars Aksel Berglund