Abstract: The invention relates to a binding compound, which binds the same epitope of human CD27 as monoclonal antibody hCD27.15, produced by hybridoma hCD27.15 which was deposited with the ATCC in on Jun. 2, 2010 under number PTA-11008. In particular the invention relates to such a binding compound of claim 1 which may comprise: an antibody heavy chain variable region which may comprise at least one CDR selected from the group consisting of SEQ ID NOs : 5, 6 and 7, or a variant of any of said sequences; and/or an antibody light chain variable region which may comprise at least one CDR selected from the group consisting of SEQ ID NOs: 8, 9 and 10, or a variant of any of said sequences.

Abstract: The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and inflammatory disorders and/or for preventing or reducing the risk of graft rejection in transplantation.

Abstract: Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with CD27L expression.

Abstract: The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate ?-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

Abstract: Provided are antibodies that specifically bind to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Also provided are compositions including these antibodies, as well as polynucleotides, vectors, host cells, and methods useful for production thereof. Further provided are methods and kits for treating or preventing cancer in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine, optionally in combination with another anti-cancer agent. Still further provided are methods and kits for treating or preventing gastrointestinal disease in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine or N-acetyl-galactosamine.

Abstract: Humanized anti-Tn-MUC1 antibodies and conjugates thereof. Conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker to the antibody are described.

Abstract: Methods for optimizing a therapeutic response in a patient (e.g., a cancer patient) to an anti-EGFR therapy, and methods for preventing or ameliorating infusion reactions in a patient receiving an anti-EGFR therapy are disclosed.

Abstract: The present invention provides molecules, including proteins, more particularly, immunoglobulins whose in vivo half-lives are altered (increased or decreased) by the presence of an IgG, constant domain, or FcRn binding fragment thereof (e.g., an Fc region or hinge-Fc region) (e.g., from a human IgGI, e.g., human IgGI), that have modifications of one or more of amino acid residues in at least the CH3 domain.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: The purpose of the present invention is to provide a monoclonal antibody that is useful in specifically assaying tartrate resistant acid phosphatase 5b (TRACP-5b). A hybridoma producing a monoclonal antibody against TRACP-5b, said monoclonal antibody showing higher reactivity with TRACP-5b than with tartrate resistant acid phosphatase 5a (TRACP-5a) and, therefore, being specific to TRACP-5b, is obtained by cell fusion using, as an antigen, human recombinant TRACP-5b purified from silkworm silk gland. By using this monoclonal antibody, TRACP-5b in a specimen can be highly sensitively and specifically detected.

Abstract: Novel multi specific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against intracellular components that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.

Abstract: A process for the conversion of a cellulose containing feed comprising the steps of: contacting the cellulose containing feed with a molten salt hydrate and mildly hydrolyzing the cellulose to form a solution of partially hydrolized cellulose, separating one or more components of the partially hydrolyzed cellulose from the solution, converting the separated one or more components of the partially hydrolyzed cellulose in a thermo-catalytic process.

Abstract: Hydroxypropyl methyl cellulose having a high thermal gel strength even at a low viscosity is provided and utilized. Specifically provided is hydroxypropyl methyl cellulose having such properties that a 2% by weight aqueous solution of the hydroxypropyl methyl cellulose has a viscosity at 20° C. of 300 to 2,000 mPa·s and a storage elastic modulus at 85° C. of 2,000 to 4,500 mPa. Also provided is a food comprising the hydroxypropyl methyl cellulose. Further provided is a method for producing the hydroxypropyl methyl cellulose, the method comprising a step of depolymerizing, with an acid, high-viscosity hydroxypropyl methyl cellulose having such a property that a 2% by weight aqueous solution of the high-viscosity hydroxypropyl methyl cellulose has a viscosity at 20° C. of 70,000 to 100,000 mPa·s to obtain the hydroxypropyl methyl cellulose.

Abstract: Compositions comprising oxidized poly alpha-1,3-glucan compounds are disclosed herein. Oxidized poly alpha-1,3-glucan compounds are produced by contacting poly alpha-1,3-glucan under aqueous conditions with at least one N-oxoammonium salt.

Abstract: A process for preparing a (meth)acrylate comprising preparing an aqueous phase by combining water, one or more stabilizing agents, and one or more surfactants; preparing an oil phase by combining one or more free radical initiators, one or more monomers capable of undergoing radical polymerization, one or more crosslinking and/or graft-linking monomers, and stearyl methacrylate and/or lauryl methacrylate, wherein the free radical initiator is capable of partitioning preferentially into the oil phase; combining the aqueous and oil phases and mixing to form a suspension having oil droplets ranging in size from 1 to 10 microns; raising the temperature of the suspension to effect an initial polymerization forming a core polymer is provided.

Abstract: The present invention describes a metallocene catalyst based on a transition metal of group 4 or 5 of the periodic table, supported on a hybrid catalytic support provided with aliphatic organic groups, and a process for supporting metallocene on the hybrid catalytic support. The supported metallocene catalyst provides an ethylene polymer with broad or bimodal molecular weight distribution, in the presence of only one metallocene complex on the support.

Abstract: The present invention describes a metallocene catalyst based on a transition metal of group 4 or 5 of the periodic table, supported on a hybrid catalytic support provided with aliphatic organic groups, and a process for supporting metallocene on the hybrid catalytic support. The supported metallocene catalyst provides an ethylene polymer with broad or bimodal molecular weight distribution, in the presence of only one metallocene complex on the support.

Abstract: The present invention relates to a method for preparing a high activity olefin polymerization catalyst, which is easy to be produced, reducing complicated steps, and can be produced at low temperature, wherein said method comprising the following steps: • (a) adding a magnesium halide into an alcohol solvent; • (b) precipitating the solution obtained from (a) in a solution of an organic solvent containing an organo compound of group III element; • (c) adding a titanium compound into the mixture obtained from (b) to obtain a catalyst; • (d) treating the catalyst obtained from (c) with an organoaluminium compound at a temperature ranging from 0 to 60° C. for 2 to 5 hours, wherein the mole ratio of aluminium to titanium (Al/Ti) for treatment is in a range of 1 to 30.

Abstract: A polymer-encapsulated pigment dispersion is prepared from a mixture of (a) a carrier; (b) pigment particles; and (c) a polymeric dispersing agent having a polymer backbone, and an alkali-swellable copolymer component. The dispersing agent may provide efficient pigment wetting and dispersion using relatively low and thus economical dispersant amounts, and subsequently enable formation of polymer-encapsulating pigment dispersions that, when used in coatings, provide good opacity and good hiding characteristics, especially in titanium dioxide-containing coating compositions.

Abstract: [Object] To provide a method for stably producing a water-absorbent resin in powder form or particle form, which has excellent physical properties such as water absorption performance and the like, without any production trouble. [Solution] A method for producing a water-absorbent resin includes mixing a monomer composition, which contains at least a monomer and a pyrolytic polymerization initiator, with an organic solvent, a temperature of the organic solvent is not lower than 70° C. at time of mixing, and when a mass per unit time of the monomer in the monomer composition to be mixed with the organic solvent is expressed as an amount per unit volume of the organic solvent, a lower limit is 0.01 g/ml/min, and an upper limit is 0.2 g/ml/min.

Abstract: A propylene-based impact copolymer having a high gloss and suitable for appliance components comprising a polypropylene homopolymer and within a range of from 6 wt % to 20 wt % of propylene copolymer based on the weight of the impact copolymer, wherein the copolymer comprises from 20 wt % to 44 wt % ethylene, and/or C4 to C10 ?-olefin derived units and the remainder propylene-derived units based on the weight of the propylene copolymer, the impact copolymer having a melt flow rate (230° C./2.16 kg) within a range of from 10 g/10 min to 50 g/10 min.

Abstract: A method for preparing polybutene includes the steps of: supplying a C4 mixture to an isomerization reactor in which (i) 1-butene is isomerized into 2-butene by a hydrogen isomerization reaction using an isomerization catalyst in an isomerization zone of the isomerization reactor and (ii) iso-butene and 2-butene are separated by fractional distillation in a fractional distillation zone; supplying a C4 mixture containing 2-butene which is separated in the isomerization reactor to a skeletal isomerization reactor, in which a part of normal-butene is skeletal isomerized into iso-butene by a skeletal isomerization reaction using a skeletal isomerization catalyst, and the obtained skeletal isomerization mixture is supplied and recycled to the isomerization reactor; and supplying (i) a raw material containing the iso-butene of high concentration and which is separated from the isomerization reactor and (ii) a polymerization catalyst to a polybutene polymerization reactor and thereby producing polybutene by a polyme

Abstract: The invention provides a molecular transition metal complex selected from Formula 1, as described herein; an ethylene-based polymer; and a process to form the ethylene-based polymer, said process comprising polymerizing ethylene in the presence of at least one molecular transition metal complex selected from Formula 1, as described herein, and wherein either Z1 or Z2 is dative covalent (coordinate) to the metal (M).

Abstract: The invention provides compositions, each comprising an ethylene/alpha-olefin interpolymer, which has a reduced level of a low density, low molecular weight oligomeric fraction, as indicated by an HCC value, as described herein, and reduced levels of inorganic content or lower Tm. The invention also provides processes for forming such interpolymers.

Abstract: A method for providing a polymer having terminal functionality involves reacting a terminally active polymer with an ?,?-ethylenically unsaturated compound that includes a group 2-13 element so as to provide a functionalized polymer. The resulting polymer exhibits enhanced interactivity with particulate fillers and can be used in the manufacture of vulcanizates.

Abstract: The present invention relates to a solventborne, pigmented coating composition, which comprises, based on the total amount of the coating composition, 0.02 to 0.75 wt % of at least one copolymer (A), where the copolymer (A) is obtainable by copolymerization of a mixture of olefinically unsaturated monomers (a) in at least one organic solvent, the mixture of monomers (a) to be polymerized consists of (a1) 10 to 60 mol % of at least one monomer of the formula (I) below where R1=C1 to C4 alkoxy, R2=C1 to C4 alkyl, and m=0 to 2, and also (a2) 40 to 90 mol % of at least one further olefinically unsaturated monomer, and the copolymer (A) possesses a glass transition temperature Tg of at least ?30° C. The present invention also relates to a method for producing a multicoat paint system using the coating composition, and to the multicoat paint systems themselves.

Abstract: Disclosed is a conjugated diene polymer comprising a conjugated diene as a monomeric unit. The conjugated diene polymer is obtained by a polymerization reaction in a reaction solution comprising a conjugated diene, at least one compound selected from the group consisting of limonene, terpinene, and terpinolene, and an organoalkali metal compound as a polymerization initiator. Mz/Mn is 1.7 or more and 4.0 or less, when Mz is a Z-average molecular weight of the conjugated diene polymer, Mn is a number average molecular weight of the conjugated diene polymer, and the Z-average molecular weight and the number average molecular weight are values in terms of polystyrene by gel permeation chromatography.

Abstract: The present invention relates to controlled radical polymerization processes for making branched-functionalized block polyacrylate polymers and compositions formed therefrom. In particular, such reaction products are formed by ensuring that the reaction products are substantially flowable and non-gelling, indicating that substantially no polymerization has occurred. The branched-functionalized block polyacrylates may be further functionalized and/or polymerized.

Abstract: A polyester prepared by free radical polymerization of an unsaturated polyester prepolymer, wherein the polymerization occurs primarily by reaction of the unsaturation of said prepolymer is disclosed. Coatings comprising the same are also disclosed, as are substrates coated at least in part with such coating.

Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.

Abstract: A semi-crystalline thiourethane polymer. The semi-crystalline thiourethane polymer comprises a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages. Each of the first type of monomer includes two or more thiol functional groups and each of the second type of monomer includes two or more isocyanate functional groups. The first and second types of monomers are polymerized together in an anionic step-growth polymerization reaction that is catalyzed by a non-nucleophillic base having a pKa greater than 7, produced by photo-initiated decomposition of a photolatent base. A method of synthesizing, and polymer jetting and stereolithography methods of manufacturing a polymer part, are also disclosed.

Abstract: An automotive interior material comprises: a polyester needle-punched nonwoven fabric; and a polycarbonate-based polyurethane resin attached to the polyester needle-punched nonwoven fabric, wherein the polycarbonate-based polyurethane resin is obtained by reacting an organic polyisocyanate with a polyol comprising 30 to 99% by mass of a polycarbonate diol represented by the following general formula (1): wherein R1s each independently represent an alkylene group having 4 to 8 carbon atoms, and n represents an integer with which a molecular weight of the compound represented by the formula (1) is in a range from 1000 to 3500, with a mole ratio between NCO groups of the organic polyisocyanate and OH groups of the polyol (the number of moles of NCO groups/the number of moles of OH groups) being 1.5/1.0 to 1.1/1.

Abstract: The present invention relates to a process for preparing polyurethanes by mixing a) polyisocyanate, b) a mixture obtainable by introducing an alkali metal or alkaline earth metal salt into a compound comprising urethane groups, c) compounds comprising one or more epoxide groups, and, optionally, d) polyol, e) chain extenders, and f) fillers and further additives to form a reaction mixture and fully reacting the mixture to give the polyurethane, where the amount of alkali metal or alkaline earth metal ions per equivalent urethane groups in the compound (b) is 0.0001 to 3.5. The present invention further relates to a polyurethane obtainable by such a process, and to the use of such a polyurethane for producing bodywork components for vehicles.

Abstract: The invention provides a polyphenylene ether modified phenol-benzaldehyde multifunctional epoxy resin with formula (I). wherein A is: PPE are: Z are: Y are: Their manufactured is following steps: polyphenylene ether 100 parts is dissolved in solvent, then phenol-benzaldehyde multifunctional epoxy resin 100˜450 parts and catalyst 0.01˜5 parts are added, stirred and mixed at 90˜180?, for 1˜4 hour, to obtain formula (I) solution. Said product is formulated with compositions for laminate, having excellent electrical properties and heat resistance. The dielectric constant is 4.03 (1 GHz), dissipation factor is 0.0046 (1 GHz) and no delamination longer than 60 minutes dipping in 288 soldering test after 2 hours pressure cooking test. Application is insulating materials for highly reliable electronic components such as EMC, PCB substrates, laminate and insulating plates.

Abstract: A resin composition for producing a composite, wherein the composition comprises (a) resin component comprising a glycidyl bisphenol Z epoxy resin, and (b) a curing agent.

Abstract: An amine hardener system useful for curing a curable resin composition including a blend of: (I) a first amine hardener comprising at least one cycloaliphatic amine; and (II) a second amine hardener comprising at least one polyetheramine; and a curable epoxy resin composition including (A) at least one epoxy resin compound; and (B) at least one curing agent; wherein the at least one curing agent includes the above amine hardener system.

Abstract: It is to provide a more stable crystal polymorph of a clathrate compound consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane and 2-phenyl-4-methyl-5-hydroxymethylimidazole (molar ratio 1:2). A novel crystal polymorph of a clathrate compound, consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane and 2-phenyl-4-methyl-5-hydroxymethylimidazole (molar ratio 1:2) and has diffraction peaks at diffraction angles (2?) of 11.20°, 13.36°, 14.36°, 18.16°, 19.20°, 19.68°, 20.84°, 21.48°, 22.56°, 23.76° and 24.08° in a powder X-ray diffraction pattern as measured using a CuK? ray, can be obtained by, for example, further recrystallizing a crystal obtained by a conventionally known method or the like.

Abstract: Copolymers including dioxythiophene repeating units and no acceptor units allow the formation of electrochromic polymers (ECPs) with vivid neutral state colors and very colorless oxidized states that can be switched rapidly. The dioxythiophene repeating units can included in sequences where all of one type of dioxythiophene is included exclusively as isolated dyads or triads within the copolymer, or the copolymer can be an alternating copolymer with propylenedioxythiophene units. Other non-acceptor units can be included in the copolymers. The copolymers are rendered organic solvent soluble by alkyl substituents on repeating units. The inclusion of sterically encumbered acyclic dioxythiophene (AcDOT) units promotes red color while unsubstituted ethylenedioxythiophene (EDOT) units promote blue colors, and their respective content can be manipulated to achieve a desired neutral state color. Soluble copolymers comprising at least 50% EDOT repeating units can be used in supercapacitor applications.

Abstract: A polyester polymer composition having a polyester polymer with furanic units as well as a process to prepare this polyester polymer composition are herein described. The process includes the step of reacting a cyclic polyester oligomer in the presence of a catalyst in a ring-opening polymerization reaction with a reaction temperature and a reaction time sufficient to yield a polyester polymer having furanic units. The present invention further provides a method of use of this polyester polymer composition in extrusion, injection molding, or blow molding.

Abstract: The present invention relates to a method for preparing poly(trimethylene terephthalate). According to the present invention, it is possible to prepare poly(trimethylene terephthalate) containing low levels of toxic by-products such as acrolein without separate additives.

Abstract: A catalyst is prepared in situ by reaction between an aryl halide and a Ni-ligand complex. The catalyst may be used to promote chain-growth polymerization of halogen-substituted Mg or Zn monomers. Polymers, copolymers, block copolymers, polymer thin films, and surface-confined polymer brushes may be produced using the catalyst.

Abstract: The invention concerns methods and compositions for modifying a surface of a material by anchoring a surface modifying additive to a polymer matrix using an anchor molecule, wherein the surface modifying additive and the anchor molecule are both added to a melt phase of the polymer matrix.

Abstract: The present invention relates to water-soluble modified lignins preparable by enzymatic reaction of at least one water-insoluble lignin with at least one organic compound which possesses at least one group selected from primary or secondary amino group, hydroxyl group and phenyl group and has an average molecular weight in the range from 75 to 2500 g/mol. The water-soluble modified lignins are preparable under mild conditions in a simple process. They can be used as dispersants for mineral binder compositions, where they act as plasticizers and in so doing prolong the setting time to much less of an extent than the water-insoluble lignins used in their preparation.

Abstract: A method of making a molded article. The method includes introducing into a mold a composition including thermoplastic particles with hollow microspheres attached to their outer surfaces, rotating the mold, and heating the mold at a temperature at which the thermoplastic particles melt. The hollow microspheres are included in the molded article. Molded articles are also disclosed. A powder composition that includes thermoplastic powder particles and hollow ceramic microspheres attached to outer surfaces of at least some of the thermoplastic powder particles is also disclosed. The hollow ceramic microspheres are either adhered to the outer surfaces of at least some of the thermoplastic powder particles with a liquid or embedded in the outer surfaces of at least some of the thermoplastic powder particles.

Abstract: Provided is a method for producing a rubber composition that includes a rubber component (A) including natural rubber, at least one filler (B) selected from an inorganic filler and carbon black, and a monohydrazide compound (C) supported on a solid. The monohydrazide compound (C) is represented by general formula (I): R—CONHNH2, where R represents an alkyl group having from 1 to 30 carbon atoms, a cycloalkyl group having from 3 to 30 carbon atoms, or an aryl group. The method comprises compounding in an optional preliminary compounding stage and a plurality of compounding stages, and adding the monohydrazide compound (C) supported on the solid and kneading in the preliminary compounding stage and/or a first compounding stage. Also provided is a rubber composition produced with this method.

Abstract: In a method for controlling shrinkage of a composite, a dried hydrophobically modified cellulose-based fiber is exposed to a slow acting resin system having a first curing time. An excess amount of the slow acting resin system is removed to separate out the pre-wetted hydrophobically modified cellulose-based fiber. The pre-wetted hydrophobically modified cellulose-based fiber is mixed with a fast acting resin system to form a mixture. The fast acting resin system has a second curing time that is less than the first curing time. The mixture is molded at a predetermined temperature. The fast acting resin system is cured prior to the slow acting resin system, and the slow acting resin system flows into free space within the curing fast acting resin system prior to the slow acting resin system being cured.

Abstract: A method of manufacturing a laminate comprises providing a binder impregnated core layer by impregnating at least one fibrous layer with an aqueous core binder solution having a viscosity in the range 75 cP to 500 cP at a temperature of 20° C. and a bake-out solid content in the range 40 wt % to 85 wt %, in which the aqueous core binder solution comprises (i) at least 25% by dry weight of a) reducing sugar reactant(s) and nitrogen-containing reactant(s) and/or b) curable reaction product(s) of reducing sugar reactant(s) and nitrogen-containing reactant(s); and (ii) between 5% and 15% by weight of a non-aqueous solvent based on the total weight of the aqueous binder solution; providing a semi-finished assembly by assembling the binder impregnated core layer with a surface layer; and applying heat and pressure to the semi-finished assembly to cure the binder in the binder impregnated core layer and secure the core layer and the surface layer together.