Abstract: The present invention relates to therapeutic ADCs comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment, more particularly sacituzumab govitecan. The ADC is administered to a subject with a Trop-2 positive cancer that is resistant to or relapsed from prior treatment with a checkpoint inhibitor. The therapy is effective to treat cancers that are resistant to checkpoint inhibitors.

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

Abstract: Provided herein are antibodies specific for TIM3 that can be used to detect cancer cells, in particular, cancer stem cells. The antibodies can also be used in therapeutic compositions for treating cancer and reducing inflammation.

Abstract: The present invention relates to neukinase, a downstream protein kinase in the neuregulin signaling pathway. In certain aspects, the present invention provides isolated neukinase-encoding nucleic acids, neukinase polypeptides, oligonucleotides that hybridize to neukinase nucleic acids, and expression vectors containing neukinase-encoding sequences. The present invention further provides isolated host cells, antibodies, transgenic non-human animals, compositions, and kits relating to neukinase. In other aspects, the present invention further provides methods of identifying predisposition to cardiac dysfunction, methods of detecting the presence of neukinase, neukinase nucleic acid, methods of screening for agents which affect neukinase activity, and methods of modulating neukinase activity.

Abstract: The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

Abstract: The invention relates to a method for producing microfibrillated cellulose, where a suspension comprising cellulose derivative in a liquid phase which comprises an organic solvent is provided. The suspension of cellulose derivative is mechanically treated and microfibrillated cellulose is obtained. At least a part of the liquid phase from the microfibrillated cellulose is separated and microfibrillated cellulose with a dry solids content of >30 weight-% is obtained.

Abstract: The invention relates to a process for the synthesis of a polymer bearing one or more pendant hydroxyaryl groups comprising the reaction of a polymer bearing one or more pendant epoxide functional groups with a nucleophilic compound bearing the hydroxyaryl group.

Abstract: The present invention provides a polyarylene sulfide (PAS) production device which suppresses the accumulation of deposits on a baffle (baffle board) or the like disposed inside a reaction vessel via a baffle support for the purpose of enhanced stirring efficiency or the like, thereby contributing to enhanced production efficiency, reduced cost of removing accumulation, and enhanced quality of the PAS product. The PAS production device of the present invention is a PAS production device provided with a reaction vessel equipped with one or a plurality of baffles; each baffle being supported by one or a plurality of baffle supports provided in a protruding manner on an inside wall of the reaction vessel; and at least one of the baffle supports having one or a plurality of openings preferably passing through the baffle support in the vertical direction.

Abstract: A photovoltaic module comprising: (a) a photovoltaic laminate including: two or more electrically conducting dements extending through the photovoltaic laminate so that power is moved from one photovoltaic module towards another photovoltaic module or towards an inverter; and (b) one or more connectors connected to each of the two or more electrically conducting elements by a connection joint, each of the one or more connectors include: two or more opposing terminals that each are connected to and extend from one of the two or more electrically conducing elements; wherein a dielectric space is located between the two or more opposing terminals and the dielectric space blocks material used to form a connection joint from passing from a first terminal to a second terminal, the material from the connection joint cools before the material passes from one terminal to a second terminal, the material fails to travel from the first terminal to the second terminal, or a combination thereof.

Abstract: The present invention relates to a method for producing a copolymer of ethylene and a polar group-containing olefin using as a catalyst a metal complex of group 10 elements having a structure represented by formula (C4) and (C5) (in the formula, “Men” represents a menthyl group and “Me” represents a methyl group). The method of the present invention makes it possible to produce a polar group-containing olefin polymer available for various applications, as being a high molecular weight body, which has been difficult to produce, and to produce the polymer in a molecular weight range such that the polymer has good moldability.

Abstract: Novel catalytic compositions are disclosed comprising novel unsymmetrical metallocene catalytic compounds. Also disclosed are uses of such catalytic compositions in olefin polymerisation reactions, as well as processes of polymerising olefins. When compared with the prior art compositions, the catalytic compositions of the invention are markedly more active in the polymerisation of olefins.

Abstract: The present invention relates to a polyethylene homo- or copolymer having improved wear properties. In particular, the invention relates to an ultra-high molecular weight polyethylene having improved wear properties prepared using a heterogeneous Ziegler catalyst system. Said polyethylene homo- or copolymer is characterized in that the abrasion index of said polyethylene is related to the elongational stress according to the formula (I): in which ES=elongational stress as measured according to ISO 11542-2:1998 AI=abrasion index, as measured according to ISO 15527:2010 where the reference material according to ISO 15527:2010 is set to 100; ?<1.8; and ?0.015<a<?0.017.

Abstract: Provided is a photocurable resin composition containing an allylic polymer (A) which has excellent adhesion to plastic substrates.

Abstract: An object of the present invention is to provide a photocurable resin composition that has excellent adhesion to plastic substrates and can form a composition with good compatibility.

Abstract: The present invention relates to a polypropylene composition comprising a branched polypropylene (b-PP) having high melt strength (HMS). Furthermore, the present invention also relates to a method for providing the corresponding polypropylene having composition comprising the branched polypropylene (b-PP) and to a foam with the polypropylene composition comprising the branched polypropylene (b-PP). The branched polypropylene (b-PP) is based on a random copolymer with a small amount of ethylene.

Abstract: In an embodiment, a polymerization process comprises circulating, with a pump, a reaction mixture slurry in a polymerization loop reactor during a polymerization process, detecting a pressure change in the reaction mixture slurry downstream of the pump, generating, by a pressure controller, a takeoff valve actuation signal for a takeoff valve based on the pressure change, generating, by the pressure controller, a correction to the takeoff valve actuation signal, generating, by the pressure controller, a time delay for the correction, applying the correction to the takeoff valve actuation signal to generate a corrected takeoff valve actuation signal, providing the corrected takeoff valve actuation signal to the takeoff valve after the time delay, and adjusting a position of the takeoff valve in response to providing the corrected takeoff valve actuation signal. The reactor pressure is based on the takeoff valve position.

Abstract: This invention relates to organoaluminum activators, organoaluminum activator systems, preferably supported, to polymerization catalyst systems containing these activator systems and to polymerization processes utilizing the same. In particular, this invention relates to catalyst systems comprising an ion-exchange layered silicate, an organoaluminum activator, and a metallocene.

Abstract: The invention provides a process to form a composition comprising at least one ethylene-based polymer and at least one oil, said process comprising the following: polymerizing a mixture comprising ethylene, and optionally one or more comonomers, in a reactor system, comprising at least one reactor and at least one mixer, located downstream from the reactor, to form the ethylene-based polymer; and wherein the oil is added to the ethylene-based polymer upstream of the mixer. The invention also provides a reactor system for a process to form a composition comprising at least one ethylene-based polymer and at least one oil, said reactor system comprising at least one reactor, at least one mixer, and an oil feed into the ethylene-based polymer, and wherein the oil feed is located after the reactor and before the mixer.

Abstract: The object of the present invention is to provide a photocurable resin composition. which allows obtainment of a cured product that has high concealability, while being suppressed in fading due to ultraviolet light, a cured product of the photocurable resin composition, and a method for producing a cured product. The present invention relates to a photocurable resin composition containing the, following component (A) to component (D): component (A): leuco dye; component (B): photoacid generating agent; component (C): radical polymerizable compound; and component (D): ?-hydroxy acetophenone-based radical initiator which has a 5% weight loss temperature (thermal decomposition temperature) in a nitrogen atmosphere of 200° C., or higher as determined by a TGA method at a temperature increase rate, of 10° C./minute.

Abstract: The present invention is a method for producing a conjugated diene polymer comprising polymerizing at least a conjugated diene monomer using a living radical polymerization method to produce a conjugated diene polymer that comprises a halogen atom at a terminal of a polymer chain, a living radical polymerization reaction being initiated using a copper salt, a multidentate ligand that comprises a nitrogen atom having an sp2 hybridized orbital as a coordinating atom, and an organic halide, to produce the conjugated diene polymer having a number average molecular weight (Mn) of 1,000 to 1,000,000 and a molecular weight distribution (Mw/Mn) of less than 2.0. The present invention provides a method for efficiently and inexpensively producing a conjugated diene polymer that includes a halogen atom at the terminal of the polymer chain, and has the desired molecular weight and a narrow molecular weight distribution.

Abstract: A latex particle comprises an interior core and an outer shell. The core comprises an acrylic or vinyl polymer, and the shell comprises a water soluble alkyd polymer and at least one surfactant. Substantially all or all of the alkyd polymer is present in the shell of the latex particle and substantially none or none or the alkyd polymer is present in the core of the latex particle. Also described is a process for making the latex particle wherein the water soluble alkyd polymer is present as a co-surfactant during polymerization.

Abstract: The present invention provides an active energy ray-curable composition exhibiting high curability and having excellent offset printability when used for a printing ink, an active energy ray-curable printing ink having both excellent curability and offset printability, and a printed matter using the same. An active energy ray-curable composition includes a urethane (meth)acrylate resin (A) and a polymerization initiator (B), wherein the urethane (meth)acrylate resin (A) is produced by using an aromatic polyisocyanate (a), a hydroxyl group-containing mono(meth)acrylate (b), and a polyol (c) as essential reaction raw materials so that the ratio [(b?)/(a?)] of the number of moles (b?) of hydroxyl groups contained in the hydroxyl group-containing mono(meth)acrylate (b) to the number of moles (a?) of isocyanate groups contained in the aromatic polyisocyanate (a) is within a range of 0.99 to 0.40, and the urethane (meth)acrylate resin (A) has a (meth)acryloyl group concentration within a range of 1.5 to 4.0 mmol/g.

Abstract: A composition and method for producing a tertiary amine is disclosed. The tertiary amine is contacted with an inert gas. The inert gas is nitrogen or more preferably argon. The amine composition is useful in producing polyurethane foam with lower levels of chemical emissions particularly lower emissions of toxic chemicals.

Abstract: A storage stable polyol premix compositions, methods of forming such compositions, foamable compositions using the premix compositions, and methods of preparing foams containing the premix compositions, and foams made using the premix composition comprising a polyol component comprising at least 10 wt % of a cashew nutshell liquid based polyol based on a total weight of the polyol component, a tertiary amine catalyst, a silicone surfactant, and a blowing agent comprising a hydrohaloolefin are disclosed.

Abstract: A polyurethane adhesive composition that includes a polyurethane prepolymer that includes the reaction product of a first polyol component that includes glycerol monoester and a polyisocyanate, and a second polyol. A polyurethane prepolymer that includes the reaction product of glycerol monoester, a hydroxy functional triglyceride, and a poly isocyanate.

Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.

Abstract: A curable epoxy composition comprising a polyvalent epoxy compound (A) having a biphenyl structure and/or condensed polycyclic structure, a phosphorus-containing epoxy compound (B) having a structure shown by the following formula (1) or (2), and a triazine structure-containing phenol resin (C) and a film, laminated film, prepreg, laminate, cured article, and composite article obtained using the same are provided. Where, in the formula (1), each of R1 and R2 respectively independently represents a hydrocarbon group having 1 to 6 carbon atoms, the pluralities of R1 and R2 may be the same or different, and each of “m” and “n” respectively independently represents an integer of 0 to 4, and where, in the formula (2), each of R1 and R2 respectively independently represents a hydrocarbon group having 1 to 6 carbon atoms, the pluralities of R1 and R2 may be the same or different, and each of “m” and “n” respectively independently represents an integer of 0 to 5.

Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters have lower glass transition temperatures than polyesters of comparable molecular weight.

Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters are highly branched polymers, such as highly branched polymers that have low viscosity at higher molecular weights.

Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils.

Abstract: The present invention relates to a composition comprising at least one compound of the formula (1) wherein R1, R2 and R3 are the same or different and denote a C1-C10-alkyl, and at least one carrier resin.

Abstract: Provided is a method of producing a polycarbonate-polyorganosiloxane copolymer, including a step (a) of producing a polycarbonate oligomer with an alkaline aqueous solution of a dihydric phenol, phosgene, and an organic solvent, the method further including a step of setting a content of a polycarbonate-polyorganosiloxane copolymer in the organic solvent to be introduced into the step (a) to less than 850 ppm by mass.

Abstract: In an embodiment, a melt polymerization process comprises melt polymerizing a carbonate compound and a dihydroxy compound in the presence of a catalyst composition to form a polycarbonate; and adding an end-capping agent comprising a mono-phenolic compound to the polycarbonate, wherein the adding of the end-capping agent comprises at least one of adding the end-capping agent just upstream of a final polymerization unit, adding the end-capping agent directly into the final polymerization unit, and adding the end-capping agent downstream of the final polymerization unit; wherein a molecular weight of the polycarbonate increases by less than 10% downstream of the final polymerization unit.

Abstract: The present invention relates to a method for producing polyether carbonates containing alkoxysilyl groups in which (a) an unsaturated polyether carbonate polyol is reacted with (b) an alkoxysilane compound of formula (II) Si(X)m(R1)n(R2)o (II), where X=H, Y—S—H and Y=C1-C22 alkylene, C6-C14 arylene, C7-C14 aralkylene, C7-C14 alkylarylene; R1=C1-C8 alkoxy, C7-C20-aralkoxy, C6-C14 aroxy, C7-C20 alkylaroxy; R2=C1-C22 alkyl, C6-C14 aryl, C7-C14 aralkyl, C7-C14 alkylaryl, and m and n represent, independently of one another, an integer ?1, o is zero or an integer ?1 and m+n+o=4. The invention further relates to the production of a polyurethane polymer using such a polyether carbonate, a cross-linked, siloxane group containing polymer and a molded part containing or consisting of said cross-linked polymer.

Abstract: Provided is a method of producing a branched polycarbonate, including: a step (a) of subjecting an alkali aqueous solution of a dihydric phenol, phosgene, and a branching agent to a phosgenation reaction in the presence of an organic solvent to provide a reaction liquid; a step (b) of adding the alkali aqueous solution of the dihydric phenol and a polymerization catalyst to the reaction liquid obtained from the step (a) to provide a reaction liquid containing a polycarbonate oligomer; a step (c) of separating the reaction liquid containing the polycarbonate oligomer obtained in the step (b) into an organic solvent phase containing the polycarbonate oligomer and an aqueous phase; and a step (d) of causing the organic solvent phase containing the polycarbonate oligomer separated in the step (c) and the alkali aqueous solution of the dihydric phenol to react with each other to provide a reaction liquid containing the branched polycarbonate, in which a ratio (x/y) of an addition amount of the polymerization catal

Abstract: A process for preparing non-naturally-occurring defined monomer sequence polymers is provided, and in which a high degree of synthetic control is obtained by the use of solvent resistant diafiltration membranes. Also provided is a process for separating non-naturally-occurring defined monomer sequence polymers from synthetic by-products or excess reagents using solvent resistant diafiltration membranes, and a use of a solvent resistant diafiltration membrane in processes for preparing and separating non-naturally-occurring defined monomer sequence polymers.

Abstract: Fluorinated silane compounds, compositions containing the fluorinated silane compounds, and articles prepared using the fluorinated silane compounds and compositions are described. The fluorinated silane compounds can be soluble or dispersible in aqueous media, such as water, and can be used to coat articles, such as glass articles.

Abstract: The present invention relates to a polyketone copolymer consisting of repeating units represented by general formulae (3) and (4) below, and a mixture composition thereof. The present invention has excellent has barrier properties and thus can be used for vehicle fuel tanks, vehicle hydrogen tank liners, sealed food containers, etc. —(CH2CH2—CO)x—??(3) —(CH2CH(CH3)—CO)y—??(4) (wherein x and y denote the mol % of each of the general formulae (3) and (4) in a polymer).

Abstract: The present invention relates to a polyimide precursor comprising a repeating unit represented by the following chemical formula (1A) and a repeating unit represented by the following chemical formula (2A): wherein A1 is a divalent group having an aromatic ring; and R1 and R2 are each independently hydrogen, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms, wherein A2 is a divalent group having an aromatic ring; and R3 and R4 are each independently hydrogen, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms.

Abstract: This disclosure relates to a zinc complex formula (I), as defined herein, to the use of this zinc complex as a catalyst, in particular for the catalysis of a condensation reaction of organosilicon compounds. This disclosure also relates to preparations containing said compounds and to the use thereof.

Abstract: A crosslinked silicone material Y obtained by heating to a temperature of between 70 and 200° C., a crosslinkable composition X including an organopolysiloxane compound A containing, per molecule, at least two C2-C6 alkenyl radicals bonded to silicon atoms; an organohydrogenopolysiloxane compound B containing, per molecule, at least two hydrogen atoms bonded to an identical or different silicon atom; a catalyst C of formula [Ni(L1)2] where Ni represents nickel at degree of oxidation II; L1 which may be identical or different, represents a ?-dicarbonylato anion or the enolate anion of a ?-dicarbonylated compound; optionally an adhesion promoter D; and optionally a charge E.

Abstract: Provided is a method of producing a polycarbonate-polyorganosiloxane copolymer, including: a first reaction zone into which a polycarbonate oligomer, a polyorganosiloxane, and a caustic alkali are introduced to provide a reaction liquid containing the polycarbonate oligomer that has reacted with the polyorganosiloxane; and a second reaction zone into which the reaction liquid obtained from the first reaction zone, an alkaline aqueous solution of a dihydric phenol, a specific end terminator, and the caustic alkali are introduced to provide a polycondensation reaction liquid, in which a total amount of the caustic alkali to be introduced into the second reaction zone is introduced from an introduction port of the second reaction zone to perform a reaction.

Abstract: A polycarbonate-polyolefin block copolymer and a process to form a polycarbonate-polyolefin block copolymer by combining mono- or di-hydroxyaryl with vinyl/vinylidene terminated polyolefin to form a polyolefin hydroxyaryl moiety, and combining the polyolefin hydroxyaryl moiety with di-hydroxyaryl and di-substituted carbonyl monomers to form a polycarbonate-polyolefin block copolymer.

Abstract: The present invention relates to methods of processing lignocellulosic material to obtain hemicellulose sugars, cellulose sugars, lignin, cellulose and other high-value products such as asphalt and bio oils. Also provided are hemicellulose sugars, cellulose sugars, lignin, cellulose, and other high-value products such as asphalt and bio oils.

Abstract: A method for preparing non-free radical photo-crosslinked hydrogels includes: dissolving component A that is a polymer derivative modified with o-nitrobenzyl phototrigger in a biocompatible medium to obtain solution A; dissolving component B that is a polymer derivative containing hydrazide, hydroxylamine or primary amine in a biocompatible medium to obtain solution B; mixing solution A and solution B to obtain a precursor solution of hydrogel; under light irradiation, crosslinking aldehyde generated from the o-nitrobenzyl with the hydrazine, hydroxylamine or primary amine to obtain a hydrogel by forming hydrazone, oxime or schiff base, respectively. A kit for preparation and application of the hydrogel in tissue repair, beauty therapy, and cells, proteins or drugs carriers is also described. The method or kit can achieve in situ photo-gelling on tissue surface or in situ forming thin gel on wounds in clinical treatment of wounds.

Abstract: A method of forming a dendrimer hydrogel, the method comprising providing one or more amine end-functioned polyamidoamine (PAMAM) as a first reactant; providing one or more small molecule, polymer, hyperbranched molecule, or dendrimer as a second reactant, wherein the second reactant comprises one or more acrylate groups; and reacting the first reactant with the second reactant by way of conjugate addition. Compositions obtained thereby and uses thereof are also provided.

Abstract: Injection molded article for healthcare applications based on propylene homopolymer.

Abstract: The present invention relates to fiber-plastics composites consisting of (I) at least one fiber material and (II) a plastics matrix, where the composite is characterized in that the plastics matrix is based on a two-component matrix material (IIa), where the two-component matrix material (IIa) comprises (1) a parent component comprising (A) at least one polycarbonatediol and (2) a hardener component comprising (C) at least one polyisocyanate-modified polyester with from 4 to 15% isocyanate content. The present invention also relates to a process for the production of the fiber-plastics composites and to use of these.