Patents Issued in November 9, 2017
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Publication number: 20170321277Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long-coding RNAs in a sample from a subject.Type: ApplicationFiled: November 30, 2015Publication date: November 9, 2017Applicants: University of South Florida, THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTME NT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSELInventor: NIKETA A. PATEL
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Publication number: 20170321278Abstract: Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. Methods for diagnosing a mutant PKD1 gene sequence in a subject also are provided, as are methods of treating a subject having a PKD1-associated disorder.Type: ApplicationFiled: May 22, 2017Publication date: November 9, 2017Inventors: Gregory G. Germino, Terry J. Watnick, Bunyong Phakdeekitcharoen
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Publication number: 20170321279Abstract: Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ?500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of <500 base pairs results in separation of fetal from maternal DNA. A fraction of a blood plasma or serum sample of a pregnant woman containing, due to size separation (e.g. by chromatography, density gradient centrifugation or nanotechnological methods), extracellular DNA substantially comprising ?500 base pairs is useful for non-invasive detection of fetal genetic traits (including the fetal RhD gene in pregnancies at risk for HDN; fetal Y chromosome-specific sequences in pregnancies at risk for X chromosome-linked disorders; chromosomal aberrations; hereditary Mendelian genetic disorders and corresponding genetic markers; and traits decisive for paternity determination) by e.g. PCR, ligand chain reaction or probe hybridization techniques, or nucleic acid arrays.Type: ApplicationFiled: July 18, 2017Publication date: November 9, 2017Inventors: Sinuhe HAHN, Wolfgang HOLZGREVE, Bernhard ZIMMERMANN, Ying LI
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Publication number: 20170321280Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.Type: ApplicationFiled: February 27, 2017Publication date: November 9, 2017Inventors: Tuan Vo-Dinh, Hsin-Neng Wang
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Publication number: 20170321281Abstract: Techniques for treating a subject with M-GBM and recurrent GBM are provided. Example methods include obtaining at least two M-GBM tumor samples from different locations within a patient, extracting genomic DNA from each of the tumor samples, and determining whether the subject has a mutation in PI3K-AKT-mTOR (PAM) pathway in both DNA samples. If a mutation in PAM pathway is present in each of the isolated DNA samples, the method can further include treating the subject with an effective amount of an agent that inhibits the PAM pathway. Pharmaceutical agents and kits for use in the treatment of M-GBM and recurrent GBM are also provided.Type: ApplicationFiled: April 25, 2017Publication date: November 9, 2017Inventors: ANTONIO IAVARONE, RAUL RABADAN, GAETANO FINOCCHIARO, DO-HYUN NAM
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Publication number: 20170321282Abstract: The present invention relates to improved treatments of cancer resistant to a molecule of the taxoid family. It also relates to methods for selecting a patient affected with a tumor for a treatment with a molecule of the taxoid family in combination with a compound inhibiting the TGF-? signalling pathway or for determining whether a patient affected with a tumor is susceptible to benefit from a treatment with a molecule of the taxoid family in combination with a compound inhibiting the TGF-? signalling pathway as well as methods for screening or identifying a compound suitable for improving the treatment of a cancer with a molecule of the taxoid family or for reducing the resistance development during the treatment. The invention also relates to kits for performing these methods.Type: ApplicationFiled: October 28, 2015Publication date: November 9, 2017Inventors: ANNE CHAUCHEREAU, NICOLAS JEAN-PAUL MARTIN
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Publication number: 20170321283Abstract: The present invention relates to methods for the diagnosis and the treatment of cancer, in particular breast cancer. In particular, the present invention relates to a method of diagnosing cancer in a subject comprising the steps of i) determining the expression level of hGSTA1 in a tumor sample obtained from the subject, ii) comparing the expression level determined at step i) with its predetermined reference value and ii) concluding that the subject suffers from a cancer when the expression level of hGSTA1 is lower than its predetermined reference value.Type: ApplicationFiled: November 16, 2015Publication date: November 9, 2017Applicants: INSERM (Institut National De La Sante Et De La Recherche Medicale), Universite Paul Sabtier Toulouse III, AffichemInventors: Marc POIROT, Sandrine SILVENTE-POIROT, Emmanuel NOGUER
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Publication number: 20170321284Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.Type: ApplicationFiled: November 23, 2015Publication date: November 9, 2017Applicants: The Broad Institute Inc., President and Fellows of Harvard CollegeInventors: Steven Andrew McCarroll, Giulio Genovese
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Publication number: 20170321285Abstract: The invention pertains to biomarkers for identifying a cancer that is likely or not likely to evade the immune system of a subject, thus, is likely or not likely to show better prognosis (prognostic biomarker) and/or better responses to cancer therapies (predictive biomarker). The invention provides a method of identifying a subject as having a cancer that is likely to evade the immune system of the subject based on one or more of the following biomarkers in the cancer cells of the subject: a) reduced amount of NLRC5 mRNA or protein; b) reduced activity of NLRC5 protein; c) a mutation that reduces the activity of NLRC5 protein; d) increased methylation of nlrc5 or a portion thereof; and e) reduced copy number of nlrc5. These variables are useful to predict both patient survival (prognostic biomarker) and patient responses to immunotherapies (predictive biomarker).Type: ApplicationFiled: May 3, 2017Publication date: November 9, 2017Inventor: KOICHI KOBAYASHI
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Publication number: 20170321286Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.Type: ApplicationFiled: May 5, 2017Publication date: November 9, 2017Inventors: Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
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Publication number: 20170321287Abstract: An assay kit of reagents including a nucleic acid capable of acting as substrate for polymerase microorganism activity useful in a method of detecting polymerase activity as an indicator of the presence of a micro-organism in a sample are disclosed. The disclosed embodiments also relate to reagents for use in such methods, and to test kits comprising such reagents for carrying out the methods.Type: ApplicationFiled: August 12, 2015Publication date: November 9, 2017Applicant: Momentum Bioscience, LTD.Inventors: Shawn Mark O'Hara, Daniel Zweitzig
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Publication number: 20170321288Abstract: The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Fkbp10, ZdhhC6, Myrip, Actc1, AC124993.19, Runx2, AC158560.4, PlekhB1, Rps6KA2, Sept1, Sprr2k, and Flt1.Type: ApplicationFiled: November 12, 2015Publication date: November 9, 2017Applicant: Lek Pharmaceuticals d.d.Inventors: Uros Jamnikar, Marjanca Blas, Kristina Gruden
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Publication number: 20170321289Abstract: Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.Type: ApplicationFiled: July 13, 2017Publication date: November 9, 2017Inventors: Diego Ariel Rey, Nikol de Forest, Heather Cox, Soni Shukla
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Publication number: 20170321290Abstract: The current invention relates to nucleic acid impurities in a composition comprising a parvoviral vector. In particular, the current invention shows that DNA impurities are not randomly encapsulated within a parvoviral virion. The invention therefore relates to a method for identifying and quantifying a nucleic acid impurity in a composition comprising a parvoviral vector. Finally, the current invention relates to method of determining whether a composition comprising a parvoviral vector is regarded as clinically pure.Type: ApplicationFiled: November 27, 2015Publication date: November 9, 2017Applicant: uniQure IP B.V.Inventors: Jacek LUBELSKI, Wilhelmus Theodorus Johannes Maria Christiaan HERMENS
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Publication number: 20170321291Abstract: A method of manufacture to provide an efficient and economical steel deoxidizer aluminum matrix composite material that is near fully dense, free of brittle intermetallic compounds and allows for deep penetration of aluminum into molten steel thus cutting unnecessary losses of this valuable metal to parasitic oxidation reactions with slag and atmosphere.Type: ApplicationFiled: November 13, 2015Publication date: November 9, 2017Inventor: Maxim Seleznev
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Publication number: 20170321292Abstract: A method for producing a metallic component, The method includes the method steps of first machining (103) the component and thereafter cooling (105) the component from a first temperature down to a lower second temperature. The cooling (105) occurs after the machining (103) of the component.Type: ApplicationFiled: October 19, 2015Publication date: November 9, 2017Inventor: Dirk LEIMANN
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Publication number: 20170321293Abstract: Provided is a carbon steel wire excellent in shear resistance as compared with a conventional one and a method of manufacturing such a carbon steel wire. Provided is a carbon steel wire 1 having a wire diameter of from 0.1 to 0.6 mm, and when the radius of a circular cross-section orthogonal to the longitudinal direction is r and a region from the outer periphery of the circular cross-section toward the center to 0.4r is a surface layer portion 2, the occupancy ratio of a crystal texture in the [110] orientation with respect to the longitudinal direction in the surface layer portion 2 is 60% or less.Type: ApplicationFiled: November 18, 2015Publication date: November 9, 2017Applicant: BRIDGESTONE CORPORATIONInventor: Yoshiaki OONO
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Publication number: 20170321294Abstract: A method for manufacturing a steel product, is provided. A heated steel starting product at a temperature between 380° C. and 700° C., having a metastable fully austenitic structure, with a composition including, in percent by weight: 0.15%?C?0.40%, 1.5%?Mn?4.0%, 0.5%?Si?2.5%, 0.005%?Al?1.5%, with 0.8%?Si+Al?2.5%, S?0.05%, P?0.1%, at least one element chosen among Cr and Mo, such that: 0%?Cr?4.0%, 0%?Mo?0.5%, and 2.7%?Mn+Cr+3 Mo?5.7% is provided. Then the starting product is hot formed at a temperature between 700° C. and 380° C., with a cumulated strain ?b between 0.1 and 0.Type: ApplicationFiled: November 17, 2015Publication date: November 9, 2017Inventors: Artem Arlazarov, Kangying Zhu
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Publication number: 20170321295Abstract: A method for hot or warm forming a workpiece may comprise providing the workpiece to be formed, at least partially pretreating the workpiece, at least partially heating the workpiece to a target temperature, and at least partially forming and/or hardening the workpiece. Furthermore, the workpiece may be at least partially cleaned in a cleaning step between the pretreating and the heating of the workpiece. In some examples, at least partially cleaning the workpiece may involve brushing the workpiece, using a cleaning bath, or heating the workpiece with a first burner to a cleaning temperature. Further, one or more burners used to heat or clean the workpiece may be operated with a fuel gas and/or an oxygen-containing gas.Type: ApplicationFiled: November 5, 2015Publication date: November 9, 2017Applicants: ThyssenKrupp Steel Europe AG, thyssenKrupp AGInventors: Janko Banik, Sascha Sikora
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Publication number: 20170321296Abstract: Disclosed is a method for manufacturing a grain-oriented electrical steel sheet using an inhibitor-less technique, in which cold rolling includes final cold rolling with a total cold rolling reduction being set to 85% or more and a rolling reduction per pass being set to 32% or more. The final cold rolling includes one or more passes and a final pass succeeding the one or more passes and uses work rolls having a surface roughness Ra of 0.25 ?m or less in at least one of the one or more passes other than the final pass. According to this method, it is possible to stably manufacture a grain-oriented electrical steel sheet exhibiting excellent magnetic properties at low cost.Type: ApplicationFiled: November 26, 2015Publication date: November 9, 2017Applicant: JFE STEEL CORPORATIONInventors: Yasuyuki HAYAKAWA, Masayasu UENO
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Publication number: 20170321297Abstract: A high-strength cold-rolled steel sheet having a specified chemical composition and a microstructure including ferrite having an average crystal grain diameter of 2 ?m or less in an amount of 10% to 25% in terms of volume fraction, retained austenite in an amount of 5% to 20% in terms of volume fraction, martensite having an average crystal grain diameter of 2 ?m or less in an amount of 5% to 15% in terms of volume fraction, and the balance being a multi-phase structure including bainite and tempered martensite having an average crystal grain diameter of 5 ?m or less, in which a relational expression, 0.35?V2/V1?0.75 (1), is satisfied, where V1 is a volume fraction of phases which are different from ferrite and V2 is a volume fraction of tempered martensite.Type: ApplicationFiled: October 27, 2015Publication date: November 9, 2017Applicant: JFE STEEL CORPORATIONInventors: Katsutoshi TAKASHIMA, Kohei HASEGAWA, Yoshimasa FUNAKAWA
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Publication number: 20170321298Abstract: The invention relates to a device for continuous treatment of a metal strip (1), in particular a metal strip consisting of aluminum or an aluminum alloy, or consisting of a non-ferrous metal or a non-ferrous metal alloy, said device comprising at least one temperature control device (2) through which the metal strip (1) is guided in a floating manner, and comprising at least one strip position regulation unit (7), by means of which the position of the metal strip (1) can be controlled or regulated on the belt movement plane (E) and transversely to the strip running direction (B), wherein the temperature control device (2) has at least one entry-side heating section (3) and an exit-side cooling section (4).Type: ApplicationFiled: September 9, 2015Publication date: November 9, 2017Inventors: Dieter BAUKLOH, Andreas NOE, Dirk SCHAEFER
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Publication number: 20170321299Abstract: This invention relates to a process for the recovery of cobalt ions and tungstic acid and/or its derivatives from aqueous solutions, such as in particular the spent catalytic waters deriving from processes for the oxidative cleavage of vegetable oils. In particular this invention relates to a process for the recovery of cobalt ions and tungstic acid and/or its derivatives which provides for the use of cation-exchange resins.Type: ApplicationFiled: January 20, 2016Publication date: November 9, 2017Inventors: Giampietro BORSOTTI, Francesca DIGIOIA
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Publication number: 20170321300Abstract: The present disclosure concerns an apparatus suitable for smelting and separating metals in flexible oxido-reduction conditions. More particularly, it concerns an apparatus for smelting metallurgical charges comprising a bath furnace susceptible to contain a molten charge up to a determined level, characterized in that the furnace is equipped with: at least one non-transfer plasma torch for the generation of first hot gases; at least one oxygas burner for the generation of second hot gasses; and, submerged injectors for injecting said first and second hot gases below said determined level.Type: ApplicationFiled: November 10, 2015Publication date: November 9, 2017Inventors: Jeroen HEULENS, Bart DE COOMAN, Maarten QUIX
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Publication number: 20170321301Abstract: Provided is a method for recovering scandium, with which it is possible to easily and efficiently recover high-purity scandium from nickel oxide ores. This method for recovering scandium involves passing a solution containing scandium through an ion exchange resin, then subjecting the eluant eluted from the ion exchange resin to solvent extraction and separating the extraction residual liquid and the extraction agent after extraction, then performing an oxalation process on the extraction residual liquid to obtain a scandium oxalate precipitate, and roasting the precipitate to obtain scandium oxide, wherein the method is characterized in that an amine-based extraction agent is used as the extraction agent for solvent extraction.Type: ApplicationFiled: November 25, 2015Publication date: November 9, 2017Inventors: Itsumi Matsuoka, Hidemasa Nagai, Keiji Kudo, Shin-ya Matsumoto, Tatsuya Higaki, Yoshitomo Ozaki, Hirofumi Shouji, Hiroshi Kobayashi
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Publication number: 20170321302Abstract: There are provided a copper alloy for a bearing and a bearing, which can prevent seizure in Mn-Si primary crystals. The copper alloy for a bearing and the bearing according to the present invention contain 25 wt % or more and 48 wt % or less of Zn, 1 wt % or more and 7 wt % or less of Mn, 0.5 wt % or more and 3 wt % or less of Si, and 1 wt % or more and 10 wt % or less of Bi, the balance consisting of inevitable impurities and Cu, and are characterized in that, in a sliding surface on which a counter material slides, the proportion of triangles having an area of 5000 ?m2 or more and including no Bi particle with a circle equivalent diameter of 10 ?m or more, among triangles having the closest three Mn-Si primary crystals as apices, is 20 % or less.Type: ApplicationFiled: November 9, 2015Publication date: November 9, 2017Applicant: TAIHO KOGYO CO., LTD.Inventors: Yuhei EBATA, Shinji MATSUMOTO
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Publication number: 20170321303Abstract: A method of fabricating a sintered three-dimensional part, the method including: preparing an injection composition including a binder and a powder of a titanium-based alloy including aluminum and/or chromium; injecting the composition into a cavity of a mold to obtain a blank; eliminating the binder present in the blank; a first step of sintering the powder, the powder subjected to a first pressure higher than or equal to 1 mbar to obtain a preform of the part; and a second sintering step during which a second pressure, which is lower than the first pressure, is imposed, the duration for which the second pressure is applied being selected so that the content by weight of aluminum and/or chromium in a layer having a thickness of 200 ?m situated at the surface of the preform does not vary by more than 5% in relative value due to the second sintering step.Type: ApplicationFiled: November 24, 2015Publication date: November 9, 2017Inventors: Guillaume FRIBOURG, Jean-François CASTAGNE, Jean-Claude BIHR, Clément GILLOT
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Publication number: 20170321304Abstract: A three-layer clad material includes a core material, a cladding material 1, and a cladding material 2, the core material including an aluminum alloy that includes 0.5 to 1.8% of Mn, and either or both of more than 0.05% and less than 0.2% of Cu, and 0.05 to 0.30% of Ti, with the balance being Al and unavoidable impurities, the cladding material 1 including an aluminum alloy that includes 3 to 10% of Si, and 1 to 10% of Zn, with the balance being Al and unavoidable impurities, and the cladding material 2 including an aluminum alloy that includes 3 to 13% of Si, and 0.05% or less of Cu, with the balance being Al and unavoidable impurities, wherein the Si content X (%) in the cladding material 1 and the Si content Y (%) in the cladding material 2 satisfy the value (Y-X) is ?1.5 to 9%.Type: ApplicationFiled: November 18, 2015Publication date: November 9, 2017Applicant: UACJ CORPORATIONInventors: Tomohiro Shoji, Naoki Yamashita, Toshikazu Tanaka, Hirokazu Tanaka
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Publication number: 20170321305Abstract: The present disclosure provides a magnesium alloy and a preparation method and an application thereof. Based on the total weight of the magnesium alloy, the magnesium alloy includes 2-3.5 wt % of Ce, 0.01-0.2 wt % of R, 0.8-1.5 wt % of Mn, 0-0.01 wt % of Fe, 0-0.01 wt % of Cu, 0-0.01 wt % of Ni, 0-0.01 wt % of Co, 0-0.01 wt % of Sn, 0-0.01 wt % of Ca, and 94.74-97.19 wt % of Mg, wherein R is at least one selected from Al and Zn.Type: ApplicationFiled: April 8, 2015Publication date: November 9, 2017Applicant: BYD COMPANY LIMITEDInventors: Faliang ZHANG, Youping REN, Qing GONG
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Publication number: 20170321306Abstract: Embodiments of the present disclosure include compositions that include magnesium and gadolinium or magnesium and one or more metals.Type: ApplicationFiled: July 20, 2017Publication date: November 9, 2017Inventors: MICHELE VIOLA MANUEL, HUNTER B. HENDERSON, KELLY A. JORDAN
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Publication number: 20170321307Abstract: An iron soap having a content A (%) of free fatty acid being 0.01?A?8.0, a content B (%) of water soluble salt being 0.01?B?0.5, and a granularity summary value C indicated in Formula (1) being 0.1?C?5.0, wherein the iron soap is a salt of a straight-chain saturated fatty acid having from 12 to 22 carbons and an iron. Granularity summary value C=(D90?D10)/D50(where 1.0?D50?40.Type: ApplicationFiled: November 16, 2015Publication date: November 9, 2017Inventor: Takeshi YOSHIMURA
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Publication number: 20170321308Abstract: A magnetic powder is represented by general formula Fea(SibBcPd)100-a, and is produced with a gas atomization method. When the value of a and the value of b in the general formula is represented (a, b), (a, b) is within a predetermined region V1. Similarly, (a, c) and (a, d) are within a predetermined region, respectively. Whereby, it is possible to obtain an alloy magnetic powder which has high saturation magnetic flux density, low magnetic loss, and is spherical and easy to handle; and a magnetic core, a variety of coil components, and a motor can be realized by using the magnetic material.Type: ApplicationFiled: July 27, 2017Publication date: November 9, 2017Applicants: Murata Manufacturing Co., Ltd., Tohoku Magnet Institute Co., Ltd.Inventors: Toru TAKAHASHI, Kazuhiro HENMI, Akihiro MAKINO, Noriharu YODOSHI
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Publication number: 20170321309Abstract: Provided is a high-carbon steel wire rod with excellent wire drawability, containing predetermined chemical components and the balance: Fe and impurities. In a cross-section perpendicular to a longitudinal direction, an area fraction of pearlite is equal to or more than 95% and equal to or less than 100%, an average block size of the pearlite is 10 ?m to 30 ?m and standard deviation of block size is 20 ?m or less, and when Ceq.=C (%)+Si (%)/24+Mn (%)/6, a tensile strength is equal to or more than 760×Ceq.+255 MPa and equal to or less than 760×Ceq.+325 MPa, reduction of area in a tensile test is ?65×Ceq.+96(%) or more, and standard deviation of the reduction of area is 6% or less.Type: ApplicationFiled: August 3, 2015Publication date: November 9, 2017Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Makoto OKONOGI, Daisuke HIRAKAMI
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Publication number: 20170321310Abstract: A ferritic stainless steel for a fuel cell includes, in mass %, Cr: 11 to 25%, C: 0.03% or less, Si: 2% or less, Mn: 2% or less, Al: 0.5 to 4.0%, P: 0.05% or less, S: 0.01% or less, N: 0.03% or less, Ti: 1% or less, and a balance composed of Fe and unavoidable impurities. Furthermore, in the ferritic stainless steel, the maximal concentration of Al in a surface of the ferritic stainless steel is 30 mass % or more in cation ion fraction excepting 0 in an depth direction region having twice a thickness of an oxide film having less than 0.1 ?m.Type: ApplicationFiled: July 29, 2015Publication date: November 9, 2017Applicant: NIPPON STEEL & SUMIKIN STAINLESS STEEL CORPORATIONInventors: Masaharu HATANO, Atsutaka HAYASHI, Kazuhisa MATSUMOTO
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Publication number: 20170321311Abstract: Provided is a stainless steel material suitable for diffusion bonded moldings in which diffusion bondability has been further improved without being affected by the extent of surface roughness. The present invention is a stainless steel material for diffusion bonding in which the metal structure before diffusion bonding has a multi-phase structure obtained from two or more of a ferrite phase, a martensite phase and an austenite phase, wherein: the mean crystal grain diameter in the multi-phase structure is not more than 20 ?m; ?max represented by formula (a) is 10-90; and creep elongation when a 1.0 MPa load is applied at 1000° C. for 0.5 his at least 0.2%. ?max=420C?11.5Si+7Mn+23Ni?11.5Cr?12Mo+9Cu?49Ti?47Nb?52Al+470N+189 . . . Formula (a) The element notations in formula (a) represent the contents (mass %) of the respective elements.Type: ApplicationFiled: October 16, 2015Publication date: November 9, 2017Inventors: Atsushi SUGAMA, Kazuyuki KAGEOKA, Yoshiaki HORI, Kazunari IMAKAWA, Manabu OKU
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Publication number: 20170321312Abstract: Provided is an ?+? titanium alloy hot-rolled sheet consisting of, in mass %, Al: 4.7 to 5.5%, Fe: 0.5 to 1.4%, N: less than or equal to 0.03%, Si: 0.15 to 0.40%, a ratio of Si/O: 0.80 to 2.80, [O]eq in Expression (1): more than or equal to 0.13% and less than 0.25%, and the balance: Ti and impurities. In a case where an ND direction represents a normal direction of the hot-rolled sheet, a TD direction represents a sheet-width direction of the hot-rolled sheet, a c-axis orientation represents a normal direction of a (0001) plane in an ? phase, XND represents a strongest intensity among X-ray (0002) reflection relative intensities of crystal grains in which the c-axis orientation is in a range of 30° from the ND direction, and XTD represents a strongest intensity among intensities in which the c-axis orientation is in a range of ±10 degrees in the TD direction, XTD/XND is more than or equal to 4.Type: ApplicationFiled: November 28, 2014Publication date: November 9, 2017Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Akira KAWAKAMI, Hideki FUJII, Kenichi MORI, Tomoyuki KITAURA
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Publication number: 20170321313Abstract: One embodiment of a method of refining alpha-phase grain size in an alpha-beta titanium alloy comprises working an alpha-beta titanium alloy at a first working temperature within a first temperature range in the alpha-beta phase field of the alpha-beta titanium alloy. The alloy is slow cooled from the first working temperature. On completion of working at and slow cooling from the first working temperature, the alloy comprises a primary globularized alpha-phase particle microstructure. The alloy is worked at a second working temperature within a second temperature range in the alpha-beta phase field. The second working temperature is lower than the first working temperature. The is worked at a third working temperature in a third temperature range in the alpha-beta phase field. The third working temperature is lower than the second working temperature. After working at the third working temperature, the titanium alloy comprises a desired refined alpha-phase grain size.Type: ApplicationFiled: July 26, 2017Publication date: November 9, 2017Inventors: Jean-Phillippe A. Thomas, Ramesh S. Minisandram, Robin M. Forbes Jones, John V. Mantione, David J. Bryan
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Publication number: 20170321314Abstract: The invention relates to a method for producing an anti-corrosion coating for hardenable sheet steels, wherein at least two metal layers are deposited one after another onto the steel substrate; the one metal layer is a zinc layer or zinc-based layer and the other layer is a layer composed of a metal that forms baser intermetallic phases with Zn or Fe and has a higher oxidation potential than Zn, namely Ni, Cu, Co, Mn, or Mo, or a layer based on these metals; and an anti-corrosion coating for hardenable sheet steels.Type: ApplicationFiled: November 4, 2015Publication date: November 9, 2017Inventors: Siegfried Kolnberger, Ernst Commenda
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Publication number: 20170321315Abstract: A method for manufacturing a component is provided. The method includes providing one or more notches on a surface of the component. Further, depositing a coating on the surface to provide a thickness of the coating on the surface, is performed. The method also includes removing, at least partially, the coating from the surface such that the thickness of the coating over the notches is different from the thickness of the coating on the surface adjacent to the notches.Type: ApplicationFiled: May 3, 2016Publication date: November 9, 2017Applicant: Caterpillar Inc.Inventors: Andrew Douglas Steinmetz, Douglas Trent Weaver, Roger Lee Recker
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Publication number: 20170321316Abstract: A method for applying anti-gallant coating to metal parts utilizes an ultrasonic sprayer driven by a precise manipulation device such as a robotic arm for high efficiency and precision. The method does not require masking adjacent or nearby metal parts, decreases time and money spent applying the anti-gallant coating, and is environmentally friendly.Type: ApplicationFiled: May 9, 2016Publication date: November 9, 2017Inventor: Alan C. Barron
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Publication number: 20170321317Abstract: The invention relates to a method for coating a workpiece by using a spraying device. The coating of the workpiece is performed according to at least one coating parameter and at least the following steps are performed during the coating: sensing a locational heat distribution in a working area of a surface of the workpiece; and adjusting the at least one coating parameter in accordance with the sensed heat distribution. The invention further relates to a device for coating a workpiece.Type: ApplicationFiled: September 30, 2015Publication date: November 9, 2017Inventors: Arturo Flores Renteria, Sascha Martin Kyeck, Catrina Michel, Alexandr Sadovoy, Tolga Yagci
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Publication number: 20170321318Abstract: A material source arrangement for depositing a material on a substrate in a vacuum deposition chamber is described. The material source arrangement includes a distribution pipe being configured to be in fluid communication with a material source providing the material to the distribution pipe; and at least one nozzle configured for guiding the material provided in the distribution pipe to the vacuum deposition chamber. The nozzle includes a thread for repeatedly connecting and disconnecting the nozzle to the distribution pipe. Further, a deposition apparatus for depositing material on a substrate including a material source arrangement, a nozzle for a material source arrangement, and a method for providing a distribution pipe and a nozzle for a material source arrangement are described.Type: ApplicationFiled: November 7, 2014Publication date: November 9, 2017Inventors: Stefan BANGERT, Uwe SCHÜßLER, Jose Manuel DIEGUEZ-CAMPO
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Publication number: 20170321319Abstract: A heating chamber and a semiconductor processing apparatus are provided. The heating chamber includes: a heating barrel (17) disposed in the heating chamber and located above a substrate transferring window; an annular heating device (15) disposed around an inner side of the heating barrel and configured to radiate heat from a periphery to an interior of the heating barrel; a substrate cassette (14) configured to bear multiple layers of substrates and allow the multiple, layers of substrates to be arranged at intervals in an axial direction of the heating barrel; and a substrate cassette lifting device (13) configured to drive the substrate cassette to move up into an internal spare defined by the annular heating device, or move down to a position corresponding to the substrate transferring window.Type: ApplicationFiled: December 26, 2014Publication date: November 9, 2017Inventors: Qiang JIA, Mengxin ZHAO
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Publication number: 20170321320Abstract: Embodiments of the invention provide processes to selectively form a cobalt layer on a copper surface over exposed dielectric surfaces. In one embodiment, a method for capping a copper surface on a substrate is provided which includes positioning a substrate within a processing chamber, wherein the substrate contains a contaminated copper surface and a dielectric surface, exposing the contaminated copper surface to a reducing agent while forming a copper surface during a pre-treatment process, exposing the substrate to a cobalt precursor gas to selectively form a cobalt capping layer over the copper surface while leaving exposed the dielectric surface during a vapor deposition process, and depositing a dielectric barrier layer over the cobalt capping layer and the dielectric surface.Type: ApplicationFiled: May 18, 2017Publication date: November 9, 2017Inventors: Sang-Ho YU, Kevin MORAES, Seshadri GANGULI, Hua CHUNG, See-Eng PHAN
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Publication number: 20170321321Abstract: A method of making a transparent conductive graphene hybrid, comprising the steps of providing a PMMA/Graphene hybrid, functionalizing the PMMA/Graphene hybrid, providing a transparent substrate, oxidizing the transparent substrate, treating the oxidized substrate and forming a functionalized substrate, applying the PMMA/Graphene hybrid to the functionalized substrate, removing the PMMA, and forming a transparent conductive graphene hybrid. A transparent conductive graphene hybrid comprising a transparent substrate, wherein the transparent substrate is oxidized, and wherein the transparent substrate is treated with TFPA-NH2 to form a functionalized substrate, and a layer of graphene on the functionalized substrate.Type: ApplicationFiled: April 20, 2017Publication date: November 9, 2017Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Evgeniya H. Lock, Nicholas A. Charipar, Alberto Piqué
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Publication number: 20170321322Abstract: The hard coating layer includes at least a complex nitride or carbonitride layer (2) expressed by a composition formula: (Ti1-x-yAlxMey)(CzN1-z), Me being an element selected from Si, Zr, B, V, and Cr. The average content ratio X, the average content ratio Y, and the average content ratio Z satisfy 0.60?xavg, 0.005?yavg?0.10, 0?zavg?0.005, and 0.605?xavg+yavg?0.95. There are crystal grains having a cubic structure in the crystal grains constituting the complex nitride or carbonitride layer (2). A predetermined periodic content ratio change of Ti, Al and Me exists in the crystal grains having the cubic structure.Type: ApplicationFiled: October 27, 2015Publication date: November 9, 2017Applicant: MITSUBISHI MATERIALS CORPORATIONInventors: Kenichi SATO, Sho TATSUOKA, Kenji YAMAGUCHI
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Publication number: 20170321323Abstract: Embodiments described herein generally relate to a temperature control system in a substrate support assembly. In one embodiment, a substrate support assembly is disclosed. The substrate support assembly includes a support plate assembly The support plate assembly includes a first fluid supply manifold, a second fluid supply manifold, a first fluid return manifold, a second fluid return manifold, a plurality of first fluid passages, a plurality of second fluid passages, and a fluid supply conduit. The plurality of first fluid passages extend from the first fluid supply manifold to the first fluid return manifold. The plurality of second fluid passages extend from the second fluid supply manifold to the second fluid return manifold. The plurality of fluid passages extend across an upper surface of the support plate assembly in an alternating manner. The fluid supply conduit is configured to supply a fluid to the fluid supply manifolds.Type: ApplicationFiled: May 6, 2016Publication date: November 9, 2017Inventor: John M. WHITE
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Publication number: 20170321324Abstract: A semiconductor substrate processing apparatus includes a vacuum chamber having a processing zone in which a semiconductor substrate may be processed, a process gas source in fluid communication with the vacuum chamber for supplying a process gas into the vacuum chamber, a showerhead module through which process gas from the process gas source is supplied to the processing zone of the vacuum chamber, and a substrate pedestal module. The substrate pedestal module includes a platen made of ceramic material having an upper surface configured to support a semiconductor substrate thereon during processing, a stem made of ceramic material having an upper stem flange that supports the platen, and a backside gas tube made of ceramic material that is located in an interior of the stem.Type: ApplicationFiled: July 28, 2017Publication date: November 9, 2017Applicant: Lam Research CorporationInventors: Troy Alan Gomm, Nick Ray Linebarger, JR.
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Publication number: 20170321325Abstract: Gas injector units for processing chambers having one or more of scavenging ports, differential pressure ports and variable surfaces for variable injector to substrate gap distances are described. Gas distribution assemblies and processing chambers incorporating the gas injector units are also described.Type: ApplicationFiled: April 24, 2017Publication date: November 9, 2017Inventor: Tatsuya E. Sato
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Publication number: 20170321326Abstract: A fluoro-organosiloxane composition, coating and process for depositing the coating. Substituted tetramethylenedisiloxane precursor at a flow rate (QsTMDSO) and perfluorinated propylene oxide precursor at a flow rate (QPFPO) are introduced into a process chamber at a flow rate ratio (QsTMDSO/QPFPO) in the range of 0.1 to 2.0 (g/(hr·sccm)). A pulsed DC voltage is applied to a substrate and a fluoro-organosiloxane coating is deposited on the substrate, wherein the coating exhibits a water contact angle in oil (WCA/O) of greater than 155°.Type: ApplicationFiled: May 6, 2016Publication date: November 9, 2017Inventors: Michael A. MILLER, Ronghua WEI, Gregory J. HATTON