Abstract: The present invention includes a body case having a biological sample sensor mounting portion on one end side, a temperature sensor (A) provided on the one end side inside the body case, a measurement portion connected to the biological sample sensor mounting portion, and a control portion connected to the measurement portion. A temperature sensor (B) is provided on one other end side inside the body case, and when measurement is performed by the measurement portion, temperature change amounts in the two end portions are compared using the temperature sensors (A) and (B). Furthermore, a measurement value obtained by the measurement portion is corrected using temperature information from either one of the temperature sensors (A) or (B) that is provided in the end portion on the side where the temperature change is smaller.

Abstract: This invention relates to an electrochemical sensor (1), comprising a base element (3), which is made of electrically insulating material and has a planar surface (9), and a pair of conductors (5), which are attached to said planar surface (9) of the base element (3), wherein the two conductors (5) of the pair are connected by at least one wire-shaped electrochemical working electrode (7). The invention further related to a sensor array (21), which has several previously described sensors (1), and to a method for coating a working electrode (7) of the previously described sensor (1).

Abstract: An NO2 sensor comprises a sensing electrode material that includes a compound consisting essentially of one or more elements selected from the group consisting of Mn, Co, and Fe; an element selected from the group consisting of Si and Ti; and oxygen. In an alternate embodiment, the sensing electrode material includes a compound consisting essentially of one or more elements selected from the group consisting of Mn, Co, and Fe; an element selected from the group consisting of Si and Ti; an element selected from the group consisting of Mg, Al, Li, Na, and K; and oxygen. Sensors made with these sensing electrode materials demonstrate good NO2 sensitivity and reduced sensitivity to cross-interference from NO and NH3.

Abstract: In one implementation, a chemical device is described. The sensor includes a chemically-sensitive field effect transistor including a floating gate structure having a plurality of floating gate conductors electrically coupled to one another. A conductive element overlies and is in communication with an uppermost floating gate conductor in the plurality of floating gate conductors. The conductive element is wider and thinner than the uppermost floating gate conductor. A dielectric material defines an opening extending to an upper surface of the conductive element.

Abstract: Integrated circuit (100) comprising a semiconductor substrate (110); an insulating layer (120) over said substrate; an first transistor (140) on said insulating layer, said first transistor comprising an exposed channel region (146) in between a source region (142a, 142b) and a drain region (144); and a voltage waveform generator (150) conductively coupled to the semiconductor substrate for providing the first transistor with a bias voltage during a signal acquisition period, wherein the voltage waveform generator is arranged to generate an alternating bias voltage waveform (300) comprising a periodically increasing amplitude. A sensing apparatus including such an integrated circuit and a sensing method using such an integrated circuit are also disclosed.

Abstract: A detection system includes an electrochemical sensor. Measurement circuitry is coupled to the electrochemical sensor and configured to measure an electrical characteristic of the electrochemical sensor. A controller is coupled to the measurement circuitry and is configured to provide an indication based on the measured electrical characteristic. The controller is further configured to generate an electrical disturbance to the electrochemical sensor and obtain a sensor recovery profile to provide a diagnostic indication relative to the electrochemical sensor.

Abstract: An apparatus and method for individually detecting NO and NO2 concentrations as NOX components of an object gas. An NO concentration corresponding value is obtained from a first detection element not having a reduction section. An NO concentration corresponding value is obtained from a second detection element having a reduction section, and having an NO2/NO sensitivity ratio greater than that of the first detection element. The difference ?C between the NO concentration corresponding values of the two detection elements is obtained, and divided by the difference ?S between the NO2/NO sensitivity ratios of the two detection elements, whereby an NO2 concentration corresponding value is obtained. A value obtained by multiplying the NO2 concentration corresponding value by the NO2/NO sensitivity ratio of the second detection element is subtracted from the NO concentration corresponding value of the second detection element, whereby an NO concentration corresponding value is obtained.

Abstract: A method of manufacturing a device with a planar electrode structure, the method comprising: (a) forming a microfluidic channel on a substrate; (b) applying a primer layer to at least part of the microfluidic channel, (c) applying a conductive liquid to the microfluidic channel, the conductive liquid comprising electrically conductive particles dispersed in a carrier medium, the carrier medium including a solvent; (d) allowing the conductive liquid to flow throughout the microfluidic channel by capillary action to form the planar electrode structure; and (e) evaporating the solvent from the carrier medium, is described. Devices obtainable using the method and their applications are also described.

Abstract: A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.

Abstract: A sensor including a vibrating wire is used to measure a dew point of a fluid.

Abstract: A system for inspecting a weld on a component where the weld has a plurality of cross-sections includes a camera disposed above the weld that optically senses a weld position. A projector disposed above the weld projects on to the component along a length of the weld position a primary scan path with a primary scan path start point and a primary scan path end point. An imaging probe scans the weld as the imaging probe moves from the primary scan path start point to the primary scan path end point to generate a plurality of 2D cross-sectional images of the weld corresponding to the cross-sections of the weld, the imaging probe having a position and skew angle that vary as the imaging probe moves. Each 2D cross-sectional image of the weld is optically encoded with a respective imaging probe position and a respective imaging probe skew angle.

Abstract: Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.

Abstract: Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

Abstract: Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.

Abstract: A technician is forced to determine the measurement time to be used in a selected ion monitoring (SIM) measurement while observing mass spectral data. Thus, mass spectral data and one or a plurality of mass chromatogram data items is generated on the basis of the detection results of an ion detection unit, and, for each corresponding ion component, the measurement time to be used in SIM is determined on the basis of the elution time range represented by each peak waveform of the one or plurality of mass chromatogram data items that have been generated.

Abstract: A hydrogen sensor and a method for manufacturing the same are provided. The hydrogen sensor includes a metal oxide layer formed over a substrate, and a catalytic pattern that is formed over the metal oxide layer. Further, a protective layer is formed over the catalytic pattern.

Abstract: In a gas sensor, not only a tube 70 covers lead wires 48, but also the tube 70 covers an outer peripheral surface of an end portion of an outer cylinder 46 including an open end 46a. A portion of the outer peripheral surface of the outer cylinder 46 covered with the tube 70 is gripped by a clamp 80. Thus, the clamp 80 integrally grips the tube 70 and the outer cylinder 46. Moreover, the tube 70 protrudes from the clamp 80 to a side of the outer cylinder 46 opposite from the open end 46a (protrusion amount L>0). Further, the open end 46a of the outer cylinder 46 forms a large-diameter portion whose outer diameter is larger than an inner diameter D1 of the clamp 80.

Abstract: In some embodiments, vehicle-based natural gas leak detection methods include assembling a collection of measured concentration peaks originating from a common natural gas leak according to wind direction, wind variability and inter-peak distance data, and selecting from the collection a subset of one or more representative peaks for display. Assigning peaks to a collection may be performed according to a peak overlap condition dependent upon a scaling (overlap) factor which scales the spatial reach of a peak, and according to a wind condition which determines whether a downwind event points toward an upwind event. The scaling factor may depend on wind variability and on an orientation of an inter-peak vector relative to a representative wind direction. Peak filtering is particularly useful in urban environments, where buildings channel gas plumes and one leak may lead to sequential detections of multiple concentration peaks along a path.

Abstract: The invention disclosed herein relates to novel ligands (Lx) of Formula-I for selective detection of Cr (III) in pure aqueous medium and industrially viable process for the preparation thereof. Further the invention provides the process of selective detection of Cr (III) by fluorimetry using novel ligands of Formula-I. The invention also discloses a method of solubilizing novel ligands of formula-I in pure aqueous medium with the aid of non-ionic surfactant. The invention discloses a method of selective detection of Cr (III) using novel ligands of Formula-I.

Abstract: A system and method for determining the octane rating of a fuel from a plurality of measurements at a test engine. The measurements may include a plurality of measurements regarding individual knock events, from which waveform attributes regarding the knock events can be determined and used in the calculation of the octane rating. The measurements may also include one or more environmental measurements, such as temperature, humidity, exhaust oxygen, etc., according to which the octane rating may be normalized or that may otherwise be applied into the calculation of the octane rating. The measurements may also include one or more engine property measurements corresponding to the condition of the test engine, according to which the octane rating may be normalized or that may otherwise be applied into the calculation of the octane rating, and that may be used to advise of maintenance events.

Abstract: A dispensing device for holding and dispensing strip-like objects, like test strips for analyzing a sample of bodily fluid, wherein the dispensing device holds a stack of strips. The dispensing device includes a container portion for holding the stack of strips and a dispenser portion for dispensing strips from the dispensing device, one at a time. The dispenser portion includes a movable element for applying a rotation motion to a strip to be dispensed from a first orientation, in which the strip is enclosed in the dispensing device, to a second orientation, in which the strip is at least partially exposed.

Abstract: The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium. In some embodiments, the method involves providing a first volume including polar medium and a second volume including polar medium which are separated from one another by an apolar medium, in which at least one of the first and second volumes has a layer including amphipathic molecules.

Abstract: The present invention relates to a method for testing oral malodor, in particular oral malodor from coffee. Described herein are methods for testing the efficacy of an oral care composition to reduce oral malodor, the method comprising the steps of: a) cleaning at least a part of the oral cavity with an oral care composition; b) testing a sample of exhaled breath from the cleaned oral cavity to provide a test result representing a amount of at least one oral malodor component detected in the exhaled breath; c) exposing the oral cavity to an oral malodor material including or capable of forming the at least one oral malodor component; and d) testing a sample of exhaled breath from the oral cavity to provide a test result representing an amount of the at least one oral malodor component detected in the exhaled breath.

Abstract: Systems, apparatus and methods determine the presence of a volatile substance in expired breath. Alcohol concentrations can be determined from expired breath through the use of electromagnetic detection. The systems, apparatus and methods allow measurements of volatile substances to be done accurately and quickly over a wide range of temperatures, and are easily incorporated into vehicles.

Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.

Abstract: The invention relates to a process for determining the susceptibility to nosocomical infections in a patient, comprising the measurement of the expression of sCD127 in a biological sample.

Abstract: Compositions, methods, and devices for the detection of multiple analytes with a single signal are provided.

Abstract: A cartridge (110) and a method process target components (T1, T2) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge (110) includes a reaction chamber (114) with a hydrophilic reaction surface (115). A physical barrier (116,118) on the reaction surface (115), for example a protrusion, at least partially borders an investigation region (117,117?) which includes capture probes (CP1, CP2) that specifically bind to target components (T1, T2) of the sample fluid.

Abstract: The present disclosure further provides a sensor strip. The sensor strip includes a substrate. The substrate includes a first surface, a second surface, a recess between the first surface and the second surface, and a third surface in the recess, wherein the third surface is hydrophobic. A first electrode set is disposed on top of the first surface, and a second electrode set is disposed on top of the second surface. A covering layer includes a covering surface, such as a hydrophilic surface, facing the substrate.

Abstract: An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.

Abstract: A progressive compression test cartridge that is adapted with driven flow technology that can be coupled with a digital electronic device to make the test reading result more reliable quantitatively than visual interpretation. The test cartridge can provide test results typically in one minute or less. The test cartridge can accept a sample via a droplet or a stream sampling method. In the stream sampling method, the open end of the test cartridge allows the sample pad of the test strip to be exposed to the stream of fluid. A refracting pad on the base of the test cartridge can refract the original stream vector partially along the sample pad then continue flowing to elute and release the nanoparticles from the conjugate pad onto the membrane which is pre-coated with reactant(s). Collimated compression bars can prevent flooding sample by restricting the top and bottom surface of the conjugated pad.

Abstract: The present invention describes the novel molecular entities, nanodisc clathrates, the method of preparation, and the use of these molecular entities for solution phase analysis or crystallization.

Abstract: Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

Abstract: The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of IgE-related diseases, e.g. Type I hypersensitivity, as well as for monitoring of treatment efficacy, for instance anti-IgE therapy.

Abstract: A method of detecting a pathogen in a sample. The pathogen from the sample is captured with at least one recognition element. The sample is introduced to a paper-based microfluidic device having spaced electrodes disposed thereon. An impedance magnitude of the sample is measured across the spaced electrodes to detect a presence of the pathogen in the sample. A related paper-based microfluidic device and system are also disclosed.

Abstract: A protein composition including TorsinA or TorsinA mutant, LULL1, and a nanobody obtained by immunization using TorsinA and LULL1 is used to grow complex crystals, and three dimensional structures are determined using x-ray data of the crystals. A screening platform is built based on the determined three dimensional structures for designing a drug lead to cure dystonia.

Abstract: The present invention is related to the anti-Uroplakin II antibodies, kits, cocktails, and use of anti-Uroplakin II antibodies for detection of cancer.

Abstract: A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.

Abstract: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Abstract: Provided herein, inter alia, are methods and compositions for removing a phosphopantethiene analog moiety from an ACP-phosphopantetheine conjugate thereby providing Apo-ACP proteins.

Abstract: The present invention relates to methods and other technologies that may be used to determine whether compositions (e.g., pharmaceutical compositions) comprising interleukin-10 molecules (e.g., pegylated interleukin-10) meet particular product-related specifications prior to being administered to a subject for the treatment and/or prevention of the diseases, disorders and conditions, and/or the symptoms thereof, described herein.

Abstract: There is provided a molecular marker CXCR1 for predicting response and survival in subjects afflicted with cancer who would benefit from treatment with and Epidermal Growth Factor Receptor (EGFR) targeted therapeutic.

Abstract: Provided are methods for evaluating the risk of an adverse clinical outcome in a subject, deciding whether to discharge or continue treating a subject (e.g., treatment on an inpatient basis), or to initiate or terminate treatment, selecting a subject for participation in a clinical study, and selecting a therapeutic treatment for a subject that include determining a level of ST2 in a biological sample from the subject and determining a level of galectin-3 in a biological sample from the subject. Kits are also provided that contain an antibody that specifically binds to ST2, an antibody that specifically binds to galectin-3, and instructions for using the kit to evaluate the risk of an adverse clinical outcome in a subject, to decide whether to discharge or continue treating a subject (e.g., treatment on an inpatient basis) or to initiate or terminate treatment, to select a subject for participation in a clinical study, and/or to select treatment for a subject.

Abstract: Method of diagnosis and prognosis of contrast media induced nephropathy (CIN) including the steps of i) taking a urine sample from a patient exposed to the application of contrast media, notably patients subjected to coronary angiography; ii) assessing the level of vitamin D binding protein (VDBP) in the urine sample obtained in step (i); iii) relating the urinary vitamin D binding protein level determined in step (ii) to a pre-selected threshold level. A urinary vitamin D binding protein level higher than the pre-selected threshold level indicates that the patient is at risk of renal failure and in need of a dialysis treatment.

Abstract: A detection device for cannabinoid use including a base unit and a display screen disposed on the base unit. A central processing unit and a tetrahydrocannabinol testing device are disposed within the base unit. A testing slot is disposed on a bottom portion of the base unit, with a back end of the testing slot disposed within the tetrahydrocannabinol testing device. Each of a plurality of testing strips is slidably and removably disposed within the testing slot. A printer has a pair of T-shaped attachment extensions. Each of the pair of attachment extensions and a universal serial bus plug disposed on the printer simultaneously removably and slidably engages each of a pair of attachment slots and a universal serial bus port disposed on the base unit, respectively. The tetrahydrocannabinol testing device is configured to analyze and calculate the presence and amount of tetrahydrocannabinol in a person's bloodstream.

Abstract: Described herein is a method to induce surface trafficking of the delta-Opioid Receptor (DOR) and its applications, including, leveraging the antinociceptive potential of DOR agonists to treaty neurologic disorders and to be analgesics without the adverse consequences normally associated with chronic treatment by MOR agonists by inducing surface trafficking of the delta-Opioid Receptor (DOR) and screening compounds to identify additional targets for stimulated DOR delivery.

Abstract: A multi-well fluid container that includes a container body is provided for use in an in vitro diagnostics automation system. The container body includes a first well having a first well size configured to hold a first fluid and an openable first well closure that covers a first well opening. The first well opening provides access to the first fluid in the first well when the openable first well closure is opened. The container body also includes a second well having a second well size configured to hold a second fluid and having an openable second well closure that covers a second well opening. The second well opening provides access to the second fluid in the second well when the openable second well closure is opened. The first well size of the first well is different than the second well size of the second well.

Abstract: A container inspection device includes an inlet conveyor, an outlet conveyor, a mounting table having a mounting surface, a chamber portion having an opening in a section of the chamber portion, in which a receiving space is formed when the mounting surface contacts the chamber portion to close the opening, and a transfer. The transfer is movable in the certain direction at a speed greater than the conveying speed of the cartons by the inlet conveyor. The transfer holds multiple ones of the cartons that have been conveyed by the inlet conveyor collectively and conveys the cartons to the mounting surface of the mounting table, and holds the multiple ones of the cartons mounted on the mounting surface collectively and conveys the cartons to the outlet conveyor.

Abstract: Cradles for draining liquid from containers are described herein. An example apparatus includes a housing having a bottom wall, a side wall and an open top. The housing is to receive a container having liquid. The example apparatus includes a probe extending upward from the bottom wall toward the open top and is to drain the liquid from the container when the probe is inserted into the container. The example apparatus also includes a sliding lock slidably disposed within the housing that receives a cap or top of the container when the container is inserted into the housing. The sliding lock includes a key slot. The sliding lock is movable when a cap or top of the container has a matching key that engages the key slot, which enables the sliding lock to move downward to expose the probe and drain the liquid from the container.