Abstract: A container closure is provided for use in dispensing fluids from a container, and includes a base constructed and arranged for being attached to a mouth of the container, a first port disposed on the base and in fluid communication with the mouth, a second port disposed on the base in fluid communication with the mouth, and the first and second ports being visually differentiated from each other.

Abstract: A glass container including a body having a delamination factor less than or equal to 10 and at least one marking is described. The body has an inner surface, an outer surface, and a wall thickness extending between the outer surface and the inner surface. The marking is located within the wall thickness. In particular, the marking is a portion of the body having a refractive index that differs from a refractive index of an unmarked portion of the body. Methods of forming the marking within the body are also described.

Abstract: The present invention relates to a dual-chamber pack comprising a first chamber prefilled with a suspension base and a second chamber prefilled with a powder for suspension comprising an active ingredient, wherein upon activation of the dual-chamber pack, the contents of both the chambers are mixed to form an extended release suspension composition which is characterized by having no substantial change in the in-vitro dissolution release profile of the active ingredient upon storage for at least seven days.

Abstract: In an apparatus and method of manufacturing a multi-column multi-medicine oral dissolving film according to the present invention, all processes from film feeding, medicine coating, and medicine drying to product packaging are implemented as continuous automation processes, and under the automation processes, different kinds of medicines are coated on a base film in multiple columns in a signal layer by using a plurality of nozzles supplied with the different kinds of medicines, so that it is possible to improve productivity through the automation processes, to ensure product quality due to efficiency during drying caused by maintaining the thickness of the product, and to provide a convenience in the case of taking various kinds of small-amount medicines at one time or in the case of separately and selectively taking different kinds of medicines.

Abstract: A clip-on nursing nipple assembly is disclosed which is readily portable by itself without being attached to a fluid supply and is adapted to be affixed to commonly sold water bottles or the like. The assembly has a funnel member with a nursing orifice at one end and a flanged base at the other. A skirt attached to the base forms a socket which fits over the spout of a commercially available water bottle or similar container. There is a clamping member which includes a funnel member engagement portion disposed on the funnel member, a jaw portion engageable on the spout of a water bottle, and a yoke portion connecting the funnel member engagement portion and the jaw portion and urging the base member into sealing engagement on the spout.

Abstract: A device and method for verifying the proper position of catheters in the body by means of acoustic reflectometry, the device including a sound source, one or more sound receivers, a tube with compliant walls and open distal end to be introduced through an entrance to a body cavity, the sound source and receiver(s) coupled to the proximal end of the tube, a processor for causing the sound source to generate an acoustic excitation signal, the processor processing the acoustic signals sensed by the sound receiver(s) and generating an approximation of the acoustic impulse response of the tube, and the processor analyzing the acoustic impulse response to determine the position of the tube in the body cavity.

Abstract: Disclosed are biomimetic mineral based endodontic cement compositions. An endodontic cement comprises a paste A and a paste B. The paste A comprises a pozzolanic cementitious mineral paste and the paste B is a mixture comprising polyanionic polymers, phosphates, cement setting modulators, host-inclusion particles, bioactive glasses, and radiopacity agents suspended in a liquid carrier.

Abstract: An oxidative hair dye composition contains a first agent that includes an alkaline agent and is a cream formulation and a second agent that includes an oxidant and is liquid. The oxidative hair dye composition at the time of use has a viscosity at 25° C. of 3,000 to 10,000 mPa·s. The oxidative hair dye composition further includes (A) a salt of an oxidative dye, (B) a cationic surfactant in a content of 0.15% by mass or more, (C) a nonionic surfactant having an HLB value of 17 to 20, and (D) a nonionic surfactant having an HLB value of 11 or less.

Abstract: Methods for reclaiming formula components of an antiperspirant composition and recycling formula into its component parts for recycling into an antiperspirant composition.

Abstract: An object is to provide dispersion containing lipid peptide type compound useful as low molecular weight gelator, such as lipid dipeptide and lipid tripeptide, and dissolution accelerator capable of dissolving the lipid peptide type compound at lower temperature and more easily. It is also an object to provide dispersion that can form hydrogel by simpler method and under milder condition (low temperature) and from which gel can be obtained as gel having high thermal stability, and provide method for forming the gel. Dispersion including: a lipid peptide type compound in which peptide portion formed by repetition of at least two or more identical or different amino acids is bonded to lipid portion including C10-24 aliphatic group; dissolution accelerator having, in molecules thereof, hydrophilic portion and hydrophobic portion, the hydrophilic portion having betaine structure; and water; and method for producing hydrogel by use of the dispersion.

Abstract: An exfoliant composition including: a microbead comprising a core and a shell: the core comprising an abrasive particle having an average particle size of from 50 to 1,000 microns; and the shell comprising a hydrogel. Also disclosed is a method of making the exfoliant composition and a method of using the exfoliant composition.

Abstract: An apparatus and process for forming particles. The apparatus and process employs an intermediate mixer downstream of a batch mixer.

Abstract: The present invention relates to carriers for the controlled release of active agents, comprising surface reacted natural or synthetic calcium carbonate, one or more active agents, wherein said one or more active agent is associated with said surface-reacted calcium carbonate, and wherein said surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source. It further relates to the preparation of loaded carriers, as well as their use in different applications.

Abstract: A solid or hollow particle ranging from 0.001 to 200 microns in diameter coated with Indium Tin Oxide (“ITO”) and a topical composition containing same as well as a method for protecting skin against IR radiation.

Abstract: The aim of the present disclosure was to provide an improved oxidizing agent preparation for oxidative color modifying agents, which are present as soap based gels and contain ammonia as the alkalizing agent and optionally at least one oxidation dye precursor, and have a pH in the range of from 8 to 11.5, measured at 20° C., with which homogeneous and viscosity-stable application mixtures can be produced that release less ammonia during the entire leave-in time. It was surprisingly found that aqueous hydrogen peroxide preparations which contain selected 1-alkanols, glyceryl fatty acid esters, ethoxylated fatty alcohols, polyols and oils, achieve said aim in a very satisfactory manner.

Abstract: Compositions and methods for whitening the teeth of a patient or subject are described for performing a dental prophylaxis or cleaning procedure during which at least one tooth whitening composition is applied to the surface of a stained tooth, said compositions and methods resulting in a tooth color change that is noticeable to the patient or subject immediately following the procedure. The novel procedure allows for a high degree of tooth whitening to be safely achieved in a short period of time while under the control of a dentist, dental hygienist, or other dental professional, and which at least partially coincides with the performance of a dental prophylaxis or cleaning procedure in order to save significant clinical operatory chair time compared to cleaning and whitening procedures that are performed in non-overlapping time frames or appointments. Light may also be used to enhance whitening.

Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.

Abstract: An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including a zinc salt, a plurality of long chain polyphosphates having 6 or more phosphate polymer units, and a solvent, the relative amount of organic zinc salt and long chain polyphosphates provides a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.

Abstract: Disclosed are compositions for solubilizing and/or removing a hair styling aid composition from hair. The compositions comprise at least one active solvent, wherein the active solvent is a glycol or an ester; and a carrier composition comprising a liquid vehicle. Also disclosed are methods for solubilizing and/or removing hair styling aids from hair.

Abstract: The present invention relates to a composition for dyeing keratin fibres, in particular keratin fibres such as the hair, comprising: a) at least one oxidation base 3-(2,5-diaminophenyl)-1-propanol and/or acid salts thereof or solvates thereof such as hydrates; b) at least one coupler; c) at least 10% by weight of the total weight of the composition of a fatty substance which is preferably liquid and non-silicone-based; d) at least one nonionic surfactant chosen from alkyl(poly)glycoside surfactants, esters of oxyalkylenated sorbitan and fatty acids and oxyalkylenated fatty alcohols; e) optionally at least one basifying agent; and f) optionally at least one chemical oxidizing agent. The invention also relates to a process for dyeing keratin fibres such as the hair using the composition of the invention, and to a multi-compartment device for using the composition of the invention.

Abstract: An oxidative hair dye composition includes an alkaline agent and an oxidant. The oxidative hair dye composition further includes (A) ?-naphthol in a content of 0.005 to 0.45% by mass, (B) at least one oily component selected from a higher alcohol, an ester, and a wax that are in a liquid state at 25° C., and (C) a nonionic surfactant having a polyoxyethylene chain having a number of moles of added ethylene oxide of 20 or more.

Abstract: The present invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising: a) at least one oxidation base 3-(2,5-diaminophenyl)-1-propanol and/or acid salts thereof or solvates thereof such as hydrates; b) at least one coupler; c) at least 10% by weight of the total weight of the composition of a fatty substance which is preferably liquid and non-silicone-based; d) at least one amphoteric surfactant; e) optionally at least one basifying agent; and f) optionally at least one chemical oxidizing agent. The invention also relates to a process for dyeing keratin fibres such as the hair using the composition of the invention, and to a multi-compartment device for using the composition of the invention.

Abstract: Disclosed herein are dentifrices comprising a zinc amino acid halide, which provide a precipitate of zinc oxide upon use with dilution with water and/or saliva. Methods of making and using the dentifrices are also provided.

Abstract: The invention relates to a cosmetic composition comprising: one or more linear ?-olefin sulfonates, one or more non-oxyalkylenated anionic surfactants present in the composition in an amount ranging from 1% to 20% by weight; and one or more additional surfactants chosen from amphoteric surfactants and nonionic surfactants. The invention also relates to a cosmetic treatment process using said composition, especially a process for caring for and/or cleansing keratin materials.

Abstract: Provided are an internal olefin sulfonate composition which is capable of sufficiently enhancing foamability, foam dissipation property free from a slimy feeling during rinsing, and a feel after cleansing and subsequent drying, and a cleansing composition containing the same. The internal olefin sulfonate composition comprises (A) an internal olefin sulfonate having 16 carbon atoms and (B) an internal olefin sulfonate having 12 carbon atoms, in which a content mass ratio of the component (A) to the component (B), (A/B), is from 10/90 to 90/10.

Abstract: The present invention relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in which said fibres are treated using one or more cosmetic compositions comprising a) one or more dye(s), b) one or more titanium salts and b1) optionally at least one carboxylic acid, and c) one or more anionic thickening polymers derived from the polymerization of at least one monomer bearing an organic monoacid function, and d) optionally one or more chemical oxidizing agents such as hydrogen peroxide or one or more hydrogen peroxide-generating systems.

Abstract: The present invention relates to the use of one or more particular pyridinium salts for the treatment of keratin substances, particularly human keratin fibres such as hair. The invention also relates to a method for the treatment of keratin substances using said salts and optionally one or more chemical oxidizing agents. The invention also relates to a composition for lightening keratin substances comprising one or more pyridinium salts as defined hereinafter and one or more chemical oxidizing agents. The present invention also relates to one or more particular pyridinium salts and also to compositions containing them, especially compositions comprising a physiologically acceptable medium.

Abstract: This invention relates to a cosmetic composition, which controls sebum secretion of the scalp to thus create an optimal environment for hair growth and activates growth factors for promoting hair strengthening and growth, thereby improving the health of the scalp. A method of preparing the same is also provided. In the cosmetic composition, an oligopeptide functions to create an environment suitable for hair growth by controlling the sebum secretion of the scalp, and also to activate growth factors that are effective at preventing hair loss by promoting hair growth through improvement of blood circulation in the scalp and by strengthening hair through hair follicle activity, thereby improving the health of the scalp and preventing hair loss. The oligopeptide of the invention can exhibit high safety and stability of use and high absorbability into the skin and is thus excellent in improving the health of the scalp, compared to the use of existing peptide compositions.

Abstract: The present invention provides compositions, kits and methods for treating scalp hair. The compositions include fluorinated (but not perfluorinated), non-polymeric compounds in a suitable excipient to provide beneficial effects on hair.

Abstract: A hair cosmetic composition includes an alkaline agent and an oxidant, and is constituted as a hair dye or a hair bleaching/dye removing agent. The hair cosmetic composition further includes (A) a cellulose derivative and (B) a polyethylene glycol having a number average molecular weight of 2,000 or less. The mass ratio of the content of the (B) component to the content of the (A) component is 1 to 50.

Abstract: The disclosure relates to a cosmetic product, comprising a) a cosmetic preparation, containing, in relation to its total weight, a1) 60 to 98 wt. % of at least one polar solvent; a2) 0.1 to 20 wt. % of at least one copolymer from i) styrene ii) methacrylic acid iii) and optionally other monomers; b) a device for flash evaporation of the cosmetic preparation a), and to a method using corresponding products and to the use of the cosmetic preparation a) as process material in a device for flash evaporation.

Abstract: The present invention relates to the use of at least one cross-linked polymer or a cross-linked copolymer, the polymer or copolymer comprising at least one unit derived from the polymerization of one of the monomers selected from the group consisting of acrylic acid, methacrylic acid, alkyl acrylate comprising from 1 to 30 carbon atoms and salts thereof, for stabilizing at least one perfuming agent in a composition comprising at least 3% by weight of perfuming agent(s), the perfuming agent being in the form of dispersed drops in an aqueous gel, the aqueous gel comprising water, a buffer having a pKa comprised from 4.0 to 9.0 and a base, and the size of the perfuming agent drops ranging from 0.2 ?m to 5,000 ?m.

Abstract: A combination of at least one select dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, are included in a blonding powder to reduce the damage caused to keratin fibers by an oxidative bleaching treatment.

Abstract: The disclosure relates to a cosmetic product, comprising a) a cosmetic preparation, containing, in relation to its total weight, a1) from about 60 to about 98 wt. % of at least one polar solvent; a2) from about 0.5 to about 20 wt. % of at least one copolymer from i) vinylpyrrolidone ii) vinyl acetate iii) and optionally other monomers; b) a device for flash evaporation of the cosmetic preparation a), and to a method using corresponding products and to the use of the cosmetic preparation a) as process material in a device for flash evaporation.

Abstract: Provide is an eyelash ornament cosmetic characterized by containing at least a polymer emulsion, an extender and a viscosity regulator and controlling an average particle diameter of the extender to 1 ?m more, wherein droplets put on the tips of eyelashes are dried and turned into fine spherical resin balls, and the tips of the eyelashes are ornamented to make it possible to provide the eyes with brilliantness and loveliness and further enhance stability of the quality.

Abstract: Fan Masque is a unique cosmetic paint formula. It is comprised of ingredients found in expensive spa facials that treat the skin, yet is formulated to look like paint, in bright sports team inspired colors. Fan Masque was specifically formulated to solve a the problem that my daughter and other young college women experienced. They could not fully engaging in super fan activities at events such as football games, because traditional face paints often cause skin breakouts and irritation. Fan Masque was designed to function as a face paint and facial all in one, made from only natural and organic ingredients. I experimented for months to find the right ingredients and proportions that make Fan Masque water resistant so it will not run in the rain, yet wash off easily with soap and water. It also contains a natural sunscreen which you do not find in traditional face paints or in spa treatment masks. Fan Mask is the first of a new product category thus needs patent protection for its novelty of use.

Abstract: A combination of at least one selected dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, form a bleaching paste in order to reduce the damage to keratinic fibres caused by an oxidative bleaching treatment.

Abstract: The present invention features novel cosmetic skin care compositions for improving the appearance of flushed or rosacea-affected skin.

Abstract: Methods and systems to manufacture a soap bar comprising post-brew coffee particles are disclosed. A soap bar may comprise multiple post-brew coffee ground particle sizes to take advantage of the benefits associated with each size. For example, the soap bar may comprise espresso grinds (0.20 mm), regular grinds (1.0 mm), and/or coarse grinds (1.5 mm). A saponified fat base, e.g., a milk soap base, a plant oil base, and/or an animal fat base may be obtained and heated to a consistency. Collected post-brew coffee grounds may then be added. The coffee grounds may be anywhere from 1% to 65% of the total weight of the final product, depending on the desired soap quality. The final soap product may comprise coffee ground positive and coffee ground negative layers or portion, or the coffee grounds may be evenly dispersed throughout the product.

Abstract: The present invention relates to compositions comprising banyan tree, lotus, and clover serum fractions. A method of improving the appearance of a hyperpigmented spot may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a hyperpigmented spot on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the hyperpigmented spot. The method may include the step of identifying a hyperpigmented spot on a facial skin surface. Other methods as disclosed include a method for improving the appearance of post-inflammatory hyperpigmentation.

Abstract: Sublingual formulations containing fentanyl, a pharmaceutically acceptable salt or ester thereof, ethanol, propylene glycol and menthol, as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.

Abstract: The present invention relates to a formulation for external application to the skin containing tacrolimus, which is a poorly soluble drug used as a second therapeutic agent for atopic dermatitis and, more specifically, to a composition of a hydrophilic external gel formulation capable of enhancing skin permeability of tacrolimus, and a preparation method therefor. The hydrophilic external gel formulation loaded with tacrolimus of the present invention is in an easily preparable practical form with excellent moisturizing performance, and is excellent in spreadability and has improved drug delivery, skin permeability and skin residual capacity when applied to the skin, compared to conventional ointments, and thus can be usefully used for the treatment of atopic dermatitis and other immune diseases.

Abstract: Provided are high concentration compositions of tissue kallikrein-1 (KLK1) and methods of parenterally administering such compositions to a subject in need thereof, where absorption into the circulation via, for example, intravenous or subcutaneous administration improves systemic pharmacokinetics, bioavailability, safety, and/or convenience relative to intravenous or other forms of administration. Also provided are recombinant human KLK1 (rhKLK1) polypeptides that can be readily concentrated to high protein concentrations, and substantially pure compositions thereof.

Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.

Abstract: The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or pharmaceutically acceptable salts thereof. The celecoxib present in the compositions as described herein do not show any precipitation when subjected in Fasted-State Simulated Gastric Fluid (FaSSGF) at pH 2.0, temperature of 37° C.±0.5° C. and under stirring at a speed of 50 rpm at least for 60 minutes. It also relates to the process of preparing and method of using said composition of celecoxib.

Abstract: This application discloses a caffeinated drink with cannabinoids, wherein the drink retains its original taste and appearance. This application also discloses coffee powder with cannabinoids, roasted coffee beans with cannabinoids, and loose tea leaf with cannabinoids. Methods to the make and use of the above caffeinated drinks, coffee powder, coffee beans, and loose tea leaf are also disclosed.

Abstract: Provided herein are methods for preparing liposomes comprising increased concentration of hydrophobic therapeutic agents and improved stability, and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts.

Abstract: Provided are a method for producing organic material microparticles and a method for modifying organic material microparticles, whereby it becomes possible to improve the crystallinity of organic material microparticles or achieve the crystal transformation of the organic material microparticles while preventing the growth of the organic material microparticles in a solvent. A surfactant is added to a solvent that is capable of partially dissolving organic material microparticles, and then the organic material microparticles are reacted with the solvent. In this manner, it becomes possible to improve the degree of crystallization of the organic material microparticles or achieve the crystal transformation of the organic material microparticles without substantially altering the particle diameters of the organic material microparticles.

Abstract: Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them. Various locations and methods for placement of the compositions into the tissues of the nail unit, as well as tissues surrounding the nail milt are also described.

Abstract: Dermal delivery compositions are provided. Aspects of the dermal delivery compositions include the presence of active agent-calcium phosphate particle complexes, where these complexes include uniform, rigid, spherical nanoporous calcium phosphate particles associated with one or more active agents. Also provided are methods of using the compositions in active agent delivery applications.