Patents Issued in January 2, 2018
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Patent number: 9856169Abstract: Disclosed are lost circulation treatment fluids and methods of sealing lost circulation zones. Embodiments include a lost circulation treatment fluid comprising pumice, hydrated lime, a set retarder, and water.Type: GrantFiled: October 24, 2016Date of Patent: January 2, 2018Assignee: Halliburton Energy Services, Inc.Inventors: Benjamin John Iverson, Thomas Jason Pisklak, Ronnie Glen Morgan, Kyriacos Agapiou, Lance Everett Brothers
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Patent number: 9856170Abstract: A plaster-based material, in particular a plasterboard intended for the interior fitting of dwellings, contains a mixture of casein and active charcoal. The plaster-based material is used for reducing the amount of volatile organic compounds present in the atmosphere inside dwellings, offices or public buildings.Type: GrantFiled: December 23, 2014Date of Patent: January 2, 2018Assignee: SAINT-GOBAIN PLACOInventors: Katarzyna Chuda, Caroline Demathieu-Roeltgen, Benoit Didier
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Patent number: 9856171Abstract: There is provided a Ultra-high performance glass concrete (UHPGC) including between 300 and 1000 kg/m3 of cement, between 0 and 1400 kg/m3 of glass sand (GS), between 0 and 300 kg/m3 of reactive pozzolanic material, between 150 and 900 kg/m3 of glass powder (GP), between 0 and 600 kg/m3 of fine glass powder (FGP), between 5 and 60 kg/m3 of superplasticizer, between 50 and 300 kg/m3 of fiber; and, between 130 and 275 kg/m3 of water, wherein the content of GP is of at least 3 wt % of the UHPGC, and/or the content of GS is of at least 19 wt % of the UHPGC and/or the content of FGP is of at least 0.5 wt % of the UHPGC.Type: GrantFiled: March 28, 2014Date of Patent: January 2, 2018Assignee: SOCPRA SCIENCES ET GÉNIE S.E.C.Inventors: Arezki Tagnit-Hamou, Nancy Soliman
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Patent number: 9856172Abstract: Compositions including cement and an additive and methods for making compositions and/or concrete mixtures including a cement and an additive are provided.Type: GrantFiled: August 24, 2016Date of Patent: January 2, 2018Assignee: LIGHT POLYMERS HOLDINGInventors: Valeriy Kuzmin, Easton Groves, Gagandeep Sidhu, Michael Joseph Katila
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Patent number: 9856173Abstract: Stable emulsions of silicone terminated polyethers and silicone resins are used to prepare one-component grout with very good mechanical properties gained within a short time after the grout cures by adding a proportion of aggregate to the emulsions.Type: GrantFiled: February 9, 2015Date of Patent: January 2, 2018Assignee: WACKER CHEMICAL CORPORATIONInventors: Daniel J. Mania, Uwe Scheim
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Patent number: 9856174Abstract: A binder material useful for forming a concrete type material includes, calculated on a dry, water and carbon dioxide free basis, a base component constituting 50-95 wt % of the binder material, the base component having ground granulated blast furnace slag and an activator component constituting 5-50 wt % of the binder material. The activator component includes aluminum sulfate and a sodium hydroxide generating compound. The final binder material includes, calculated on a dry, water and carbon dioxide free basis, ground granulated blast-furnace slag 35-95 wt %, aluminum sulfate AI2(SO4)3 1-25 wt %, and sodium hydroxide generating compound 4-35 wt %.Type: GrantFiled: September 26, 2014Date of Patent: January 2, 2018Inventor: Stephan Steinkeller
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Patent number: 9856175Abstract: A sintered compact according to the present invention includes: a first material that is cubic boron nitride; a second material that is an oxide of zirconium; and a third material that is an oxide of aluminum, the second material including cubic ZrO2 and ZrO, the third material including ?-Al2O3, and the sintered compact satisfying the following relation: 0.9?Izro2(111)/Ial(110)?30; and 0.3?Izro(111)/Ial(110)?3, where Ial(110), Izro2(111), and Izro(111) respectively represent X-ray diffraction intensities of a (110) plane of the ?-Al2O3, a (111) plane of the cubic ZrO2, and a (111) plane of the ZrO.Type: GrantFiled: January 26, 2016Date of Patent: January 2, 2018Assignees: SUMITOMO ELECTRIC HARDMETAL CORP., Sumitomo Electric Industries, Ltd.Inventors: Katsumi Okamura, Mayu Danda, Satoru Kukino
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Patent number: 9856176Abstract: A ceramic matrix composite includes continuous silicon carbide fibers in a ceramic matrix comprising silicon carbide and a MAX phase compound having a chemical composition Mn+1AXn, where M is a transition metal selected from the group consisting of: Ti, V, Cr, Sc, Zr, Nb, Mo, Hf, and Ta; A is a group-A element selected from the group consisting of: Al, Si, P, S, Ga, Ge, As, Cd, In, Sn, Tl and Pb; and X is carbon or nitrogen, with n being an integer from 1 to 3.Type: GrantFiled: August 25, 2016Date of Patent: January 2, 2018Assignee: Rolls-Royce High Temperature Composites, Inc.Inventors: Stephen Harris, Robert Shinavski
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Patent number: 9856177Abstract: Porous ceramic honeycomb articles for use as particulate filters and processes for making the same are described herein. The porous ceramic honeycomb articles include a fired cordierite body. The fired cordierite body has a microcrack parameter (Nb3) of about 0.05 to about 0.25 prior to exposure to a microcracking condition. After exposure to the microcracking condition, the fired cordierite body has a microcrack parameter (Nb3) at least 20% greater than the microcrack parameter prior to exposure to the microcracking condition. The fired cordierite body has a coefficient of thermal expansion (CTE) of about 7.0×10?7/° C. to about 15.0×10?7/° C. over from about 25° C. to about 800° C. prior to exposure to the microcracking condition and a coefficient of thermal expansion of about 1.0×10?7/° C. to about 10.0×10?7/° C. over from about 25° C. to about 800° C. after exposure to the microcracking condition. The microcrack parameter may include a thermal cycle or a chemical treatment.Type: GrantFiled: May 28, 2010Date of Patent: January 2, 2018Assignee: Corning IncorporatedInventors: Weiguo Miao, Jianguo Wang
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Patent number: 9856178Abstract: The invention is directed to manufacturing fertilizers having commercial levels of nitrogen reacted with organic substances. The process comprises treatment of organics with acid that acidifies and heats a mix causing the hydrolysis of polymers. The acidified organic mix is injected sequentially with a nitrogen base under conditions that result in a partially neutralized melt. The sterilized and liquefied organic matter is disbursed over recycled material for production of granules in a granulator before final drying. The process is green scalable, and safe for the location of community organics processing facilities in locations without generating a nuisance to local communities. Fertilizers also provide a green, dual nitrogen-release profile when applied to crops releasing a bolus of nitrogen over one to two weeks following application followed by a continued slow or enhanced efficiency release of nitrogen over a growing season.Type: GrantFiled: June 6, 2016Date of Patent: January 2, 2018Assignee: Anuvia Plant Nutrients CorporationInventors: Jeffrey C. Burnham, Gary L. Dahms, Barry R. Jarrett, Larry S. Murphy
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Patent number: 9856179Abstract: An agricultural potassium-fertigation method for emitter-irrigation potassium-plus fertigation feeds a potassium-plus nutrient feedstock comprised of potassium formate and additional yield-assist constituent(s) and water to an active emitter-irrigation system discontinuously, at levels of 0.15 to 50 gal./min, during one to six nonconsecutive irrigation days during a crop cycle.Type: GrantFiled: March 3, 2016Date of Patent: January 2, 2018Inventors: John C. Miller, Deborah L. Miller
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Patent number: 9856180Abstract: A method for forming a pelletized evaporite mineral product, the method comprising: forming a material comprising a liquid and at least 50% by mass of an evaporite mineral powder; and processing the material using a pan pelletizer to form pellets comprising the material, the pan pelletizer being configured so that the mean dwell time of the material in the pan of the pelletizer is in the range from 60 to 120 seconds and the mean diameter of the pellets formed by the pelletizer is in the range from 1 to 8 mm.Type: GrantFiled: June 1, 2015Date of Patent: January 2, 2018Assignee: Sirius Minerals PLCInventors: Steve Farnworth, Mike Evans, Jim Evans
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Patent number: 9856181Abstract: The present invention is a red-light-emitting composition based upon a potassium periodate oxidizer formulation, which is useful as the illuminant in the US military's M662 40 mm red star parachute projectile, and which composition is composed of readily commercially available ingredients—ingredients that are environmentally friendly. Further, the subject inventive potassium periodate formulation provides significant enhanced illumination and safety versus the current military M662 illuminant which is based upon potassium perchlorate oxidizer formulation.Type: GrantFiled: March 19, 2015Date of Patent: January 2, 2018Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Jesse J. Sabatini, Jared D. Moretti
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Patent number: 9856182Abstract: A method of conducting radiofluorination of a substrate, includes: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting a solution of the substrate with the polymer supported phosphazene base having [18F] fluoride trapped thereon obtained in step (a) for sufficient time for a radiofluorination reaction to take place.Type: GrantFiled: July 30, 2013Date of Patent: January 2, 2018Assignee: TECHNICAL UNIVERSITY OF DENMARKInventors: Fedor Zhuravlev, Bente Mathiessen
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Patent number: 9856183Abstract: A method of preparing a catalyst, comprising: (1) mixing a ZSM-5 molecular sieve, a phosphorus source, a matrix material, a bonding agent and water to formulate an aqueous slurry, wherein the total content of the components except for water is 20-50 wt % based on the total weight of the aqueous slurry; (2) spray drying the slurry obtained in step (1) to obtain a granular intermediate product; and (3) calcining the granular intermediate product obtained in step (2) to obtain the catalyst used for preparing olefin from methanol in a fluid bed. The invention also provides a catalyst prepared according to said method, and a process of preparing olefin from methanol using said catalyst. In the methanol-to-olefin process, the conversion of methanol is >99%; the propylene selectivity is high; and the C4 selectivity is up to 32%.Type: GrantFiled: January 29, 2014Date of Patent: January 2, 2018Assignee: SHANGHAI BI KE CLEAN ENERGY TECHNOLOGY CO., LTD.Inventors: Yijun Wang, Guo Rui, Fan Zhang, Yongsheng Gan, Xiaomang Zhang
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Patent number: 9856184Abstract: The invention relates to the in situ regeneration of heterogeneous oligomerization catalysts which are used in the liquid phase oligomerization of ethene.Type: GrantFiled: February 29, 2016Date of Patent: January 2, 2018Assignee: Evonik Degussa GmbHInventors: Guido Stochniol, Stephan Peitz, Dietrich Maschmeyer, Helene Reeker
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Patent number: 9856185Abstract: Methods and apparatus for refining feedstocks, such as crude or synthetic oil, and like feedstocks, are disclosed herein. In some embodiments, a reactor for refining a feedstock includes: a chamber having an inner volume to hold a liquid feedstock, a feedstock inlet port, a process gas inlet port, and an outlet port; a gas diffuser housed within the chamber and coupled to the process gas inlet port; and a radical generator coupled in fluid communication with the inner volume via the gas diffuser. In some embodiments, a method for refining feedstock includes: providing liquid feedstock to an inner volume of a reactor; flowing a radicalized process gas from a radical generator into the inner volume and into contact with the feedstock via a gas diffuser to fractionate the feedstock and produce one or more fractions of product in a vaporous mixture; and collecting a desired product from the vaporous mixture.Type: GrantFiled: October 15, 2014Date of Patent: January 2, 2018Assignee: LYTOIL, INC.Inventors: Joe Griffith Cruz, Scott Ray Mobley, Philip David Fulmer
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Patent number: 9856186Abstract: A process is described for converting at least one isomer of a dialkyl-substituted biphenyl compound, such as at least one 2,X? dialkylbiphenyl isomer (where X? is 2?, 3? and/or 4?), into at least one different isomer, 3,3?, 3,4? and/or 4,4? dialkylbiphenyl isomer. The process comprises contacting a feed comprising the dialkyl-substituted biphenyl compound isomer with an acid catalyst under isomerization conditions.Type: GrantFiled: December 2, 2015Date of Patent: January 2, 2018Assignee: ExxonMobil Chemical Patents Inc.Inventors: Michael Salciccioli, Jihad M. Dakka, Emiel de Smit, Neeraj Sangar, Scott J. Weigel, Sumathy Raman, Terry E. Helton, Lorenzo C. DeCaul, Christine N. Elia, Chuansheng Bai, Ranjita Ghose
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Patent number: 9856187Abstract: Disclosed is a process for the conversion of acyclic C5 feedstock to a product comprising cyclic C5 compounds, such as for example, cyclopentadiene, and catalyst compositions for use in such process. The process comprising the steps of contacting said feedstock and, optionally, hydrogen under acyclic C5 conversion conditions in the presence of a catalyst composition to form said product. The catalyst composition comprising a microporous crystalline ferrosilicate, a Group 10 metal, and, optionally, a Group 11 metal, in combination with an optional Group 1 alkali metal and/or an optional Group 2 alkaline earth metal.Type: GrantFiled: October 7, 2016Date of Patent: January 2, 2018Assignee: ExxonMobil Chemical Patents Inc.Inventors: Larry L. Iaccino, Jeremy W. Bedard, Wenyih F. Lai, Christopher M. Evans, Jane C. Cheng
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Patent number: 9856188Abstract: A process for the production of butadiene is presented. The process combines the separation of butenes and butadienes extracted from a non-oxidated dehydrogenation process with the separation of butenes and butadienes from an oxidative dehydrogenation process to increase the butadiene yields and reduce the equipment for the recovery of a butadiene product.Type: GrantFiled: March 31, 2017Date of Patent: January 2, 2018Assignee: UOP LLCInventors: Christopher D. DiGiulio, John J. Senetar
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Patent number: 9856189Abstract: Methods and compositions are provided for refining natural oils and for producing high-weight esters, high-weight acids, and/or high-weight derivatives thereof, wherein the compositions are made by cross-metathesizing low-weight unsaturated esters or low-weight unsaturated acids having hydrocarbon chain lengths less than or equal to C24 with an olefin feedstock, thereby forming a metathesized product composition including high-weight esters or high-weight acids having hydrocarbon chain lengths greater than C18, wherein at least a portion of the hydrocarbon chain lengths in the metathesized product are larger than the hydrocarbon chain lengths in the starting feedstock.Type: GrantFiled: June 20, 2016Date of Patent: January 2, 2018Assignee: Elevance Renewable Sciences, Inc.Inventors: Bruce Firth, Brian M. Pease, Alexander D. Ilseman, Garrett Zopp, Timothy A. Murphy, Robin Weitkamp, Michelle Morie-Bebel
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Patent number: 9856190Abstract: A separating material superior to conventional separating materials, and a separation method are provided, with which 1,3-butadiene is selectively separated and recovered from a mixed gas including 1,3-butadiene and C4 hydrocarbons other than 1,3-butadiene. A metal complex, which comprises a dicarboxylic acid compound (I) (see (I) below) represented by general formula (I), an ion of a metal such as beryllium, and a bipyridyl compound (II) represented by general formula (II), namely L-Z-L (II) (see (L) below), is characterized by including, as the dicarboxylic acid compound (I), at least two different dicarboxylic acid compounds (I). The metal complex is used as a 1,3-butadiene separating material. Formula (I) L is represented by any of the compounds below. Formula (L).Type: GrantFiled: July 1, 2014Date of Patent: January 2, 2018Assignee: SHOWA DENKO K.K.Inventors: Keisuke Kishida, Yoshihiro Watanabe, Yoshikuni Okumura
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Patent number: 9856191Abstract: In the production of fluorine-containing olefins using a chlorine-containing alkane or a chlorine-containing alkene as a starting material, a process for producing a plurality of useful fluorine-containing olefins with high selectivity using the same raw material, the same equipment, and the same conditions is provided. The present invention provides a process for producing fluorine-containing olefins, the process comprising reacting a chlorine-containing compound represented by a specific formula and anhydrous hydrogen fluoride in the presence of oxidative gas and a fluorination catalyst, wherein the fluorination catalyst is a catalyst in which at least one metal element M selected from the group consisting of Group VIII and Group IX is present together with chromium. This production process can simultaneously produce two or more fluorine-containing olefin compounds, including HFO-1234yf and HFO-1234ze, with high selectivity.Type: GrantFiled: May 27, 2016Date of Patent: January 2, 2018Assignee: DAIKIN INDUSTRIES, LTD.Inventors: Shun Ohkubo, Daisuke Karube
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Patent number: 9856192Abstract: A method for preparing 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene, including: providing a first reactor including a first section, a second section, and a third section, with each section being filled with different catalysts, preheating hexafluoropropylene and hydrogen, and introducing the hexafluoropropylene and the hydrogen to the first reactor to yield a first mixture including: 1,1,1,2,3-pentafluoropropane, 1,1,1,2,3,3-hexafluoropropane, and hydrogen fluoride; introducing the first mixture to a first distillation column to yield 1,1,1,2,3,3-hexafluoropropane at a top of the first distillation column and 1,1,1,2,3-pentafluoropropane and hydrogen fluoride at a bottom of the first distillation column, recycling the 1,1,1,2,3,3-hexafluoropropane to a lower part of the first section of the first reactor, and introducing the 1,1,1,2,3-pentafluoropropane and the hydrogen fluoride to a second reactor to yield a second mixture including: 2,3,3,3-tetrafluoropropene, 1,3,3,3-tetrafluoropropene, hydrType: GrantFiled: January 12, 2017Date of Patent: January 2, 2018Assignees: ZHEJIANG QUZHOU JUXIN FLUORINE CHEMICAL CO., LTD., ZHEJIANG QUHUA FLUOR-CHEMISTRY CO., LTD.Inventors: Jun Lei, Aiguo Wang, Bo Yang, Yan Zhang, Huadong Zhou, Yang Zhao, Guoan Liu, Yi Zhu, Gang Su
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Patent number: 9856193Abstract: The production of 1,1,2-trifluoro-2-(trifluoromethyl)cyclobutane (TFMCB). More specifically, the present invention relates to a process for making 1,1,2-trifluoro-2-(trifluoromethyl)cyclobutane via a continuous catalytic reaction from commercially available raw materials ethylene and hexafluoropropene.Type: GrantFiled: May 1, 2017Date of Patent: January 2, 2018Assignee: Honeywell International Inc.Inventors: Haridasan K. Nair, Rajiv Banavali, Yian Zhai, Glenn Matthies
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Patent number: 9856194Abstract: Catalysts for the reduction of CO2 are described herein. More specifically, catalysts of Formula I and Formula II: wherein LB is a Lewis base; LA is a Lewis acid; R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; and R9 and R10 are independently selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; are described. A process for the production of methanol from CO2 using such catalysts is also described.Type: GrantFiled: April 23, 2014Date of Patent: January 2, 2018Assignee: Université LavalInventors: Frédéric-Georges Fontaine, Marc-André Courtemanche
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Patent number: 9856195Abstract: A process for preparing cyclic dehydration products from sugar alcohols is described. The process involve using a mixed-acid catalyst reaction mixture containing a reducing acid, having a pKa of about 1.0-1.5, and at least a strong Brønsted acid or a Lewis acid, having a pKa?0, or both acids in a solution to dehydrate and ring close said sugar alcohol. Synergistically, the mixed-acid catalysis can produce greater amounts of the desired product at similar levels of compositional accountability than either of the component acid catalysts acting alone.Type: GrantFiled: December 12, 2014Date of Patent: January 2, 2018Assignee: Archer-Daniels Midland CompanyInventors: Kenneth Stensrud, Alexandra Sanborn, Stephen Howard, Erik Hagberg
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Patent number: 9856196Abstract: Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein R1 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkyl group having 1 to 6 carbon atoms, R4 represents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond.Type: GrantFiled: January 4, 2013Date of Patent: January 2, 2018Assignee: Kao CorporationInventors: Kazuki Kinoshita, Tomohiro Shirai, Kentaro Kumihashi, Hirohisa Fujihara, Nanae Mugita
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Systems and methods for manufacture of dimethyl ether (DME) from natural gas and flare gas feedstock
Patent number: 9856197Abstract: Disclosed is a method that reforms flare gas or other raw natural gas source, using air without steam, to directly produce dimethyl ether (DME), a direct diesel substitute. The method first reforms an air-natural gas mixture at ambient atmospheric pressures, and then compresses the resulting CO-hydrogen-nitrogen gas mixture to 100-2,000 psi, and feeds it through a combined reactor which reacts the gas mixture directly into DME. The nitrogen is returned to the atmosphere. DME is an excellent diesel fuel, and can be used to displace significantly costlier and dirtier petroleum-based diesel fuel, while solving a critical problem with flaring or other wasted natural gas. For example, the roughly 120 billion cubic feet per year that was flared in North Dakota in 2014 could be converted into over 3 million tons of DME using the disclosed method.Type: GrantFiled: March 1, 2017Date of Patent: January 2, 2018Assignee: Pioneer Energy, Inc.Inventors: Robert M Zubrin, Boris Nizamov, Thomas L Henshaw, Adam M Kortan, James Siebarth, Colin Apke, Mark Berggren -
Patent number: 9856198Abstract: The present invention relates to integrated processes for using hydroformylation reaction strategies to efficiently convert ethylene in ethylene feed mixtures into C3 products (i.e., products comprising 3 carbon atoms) such as propionaldehyde, 1-propanol, propylene, propanoic acid, and the like. An aspect of the present invention is to partially purify a feed comprising an ethane/ethylene mixture rather than to attempt more complete purification. In contrast to substantially complete purification of ethylene, partial purification is technically and economically feasible at lower cost and allows hydroformylation to be practiced at high productivity and with a lower hydrogen and CO requirement. The lower volumes of such syngas used in the hydroformylation reaction, as well as a more favorable profile of leftover reactants in following hydroformylation makes recycle strategies much easier to practice.Type: GrantFiled: December 8, 2015Date of Patent: January 2, 2018Inventors: Brian T. Keen, Peter M. Loggenberg, Donald C. Power
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Patent number: 9856199Abstract: The present invention relates to a process for reacting isopulegol to menthone in the gas phase and to the use of the reaction products thus prepared as additives in foods, cosmetics, pharmaceutical products, tobacco formulations, household products, and laundry care products.Type: GrantFiled: March 6, 2015Date of Patent: January 2, 2018Assignee: BASF SEInventors: Volker Hickmann, Stefan Rüdenauer, Martine Dehn, Andreas Keller, Stephanie Renz, Daniel Schneider
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Patent number: 9856200Abstract: The present disclosures and inventions relate to a supported catalyst composition for the catalytic oxidation of a hydrocarbon such as propane with oxygen or air, in the presence of a catalyst composition comprising a support material and a mixed metal composition comprising metals in the molar ratios described by the formula MoaVbGacPddNbeZf, wherein the support material is neutral or oxidative.Type: GrantFiled: April 22, 2014Date of Patent: January 2, 2018Assignee: Saudi Basic Industries CorporationInventors: Khalid Karim, Abdulaziz Al Jodai
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Patent number: 9856201Abstract: The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicyaldehyde compounds, processes for preparing 5-halo-3,6-dichlorosalicylic acid compounds, processes for preparing 5-halo-3,6-dichlorosalicyaldehyde compounds, processes for preparing 3,6-dichlorosalicylic acid compounds, and processes that employ such compounds as intermediates in the preparation of the herbicide dicamba.Type: GrantFiled: June 3, 2015Date of Patent: January 2, 2018Assignee: Monsanto Technology LLCInventors: Terri L. Boehm, Mangesh Bore, Jeffery N. Carroll, G. Davis Harris, Jr., Matthew D. McReynolds, Justin R. Struble, Daniel P. Walker
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Patent number: 9856202Abstract: Process for the recovery of carboxylic acid, in particular acetic acid containing carboxylic anhydride in particularacetic anhydride and other impurities, which comprises: (a) treating a fraction, in particular a fraction originating from a wood treatment process, containing carboxylic acid and impurities with a metal salt in the presence of water, (b) treating at least part of the fraction obtained from step (a) to remove metal salt and, (c) treating at least part of the fraction obtained from step (b) by distillation, stripping or membrane separation to recover at least a purified carboxylic acid fraction.Type: GrantFiled: May 6, 2015Date of Patent: January 2, 2018Assignee: SOLVAY ACETOW GMBHInventors: Thomas Krumrey, Andreas Hummel
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Patent number: 9856203Abstract: The invention relates to a process for the isolation of levulinic acid from an organic solution, comprising washing said organic solution with an alkaline aqueous stream to yield a washed organic solution; subjecting the washed organic solution to a distillation to yield a distillate and a distillation residue; and recovering levulinic acid from the distillate or the residue. This process may result in high yields of levulinic acid.Type: GrantFiled: July 10, 2014Date of Patent: January 2, 2018Assignee: Georgia-Pacific LLCInventors: Pierre Louis Woestenborghs, Rinke Marcel
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Patent number: 9856204Abstract: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: May 19, 2011Date of Patent: January 2, 2018Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY VETERANS AFFAIRSInventors: Christopher M. Adams, Steven D. Kunkel, Manish Suneja, Michael Welsh
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Patent number: 9856205Abstract: The invention “Method for selective synthesis of N-methyl-para-anisidine” relates to chemical technology processes, namely to catalytic alkylation of aromatic amines and nitro compounds. The invention relates to the method for synthesis of N-methyl-para-anisidine (N-methyl-para-methoxyaniline; N-methyl-para-amino anisole) from para-anisidine (para-amino anisole; para-methoxyaniline) or para-nitro anisole (1-methoxy-4-nitrobenzene) and methanol in the presence of hydrogen or without hydrogen on heterogeneous catalyst. Proposed method permits to use existing process plants used for obtaining aniline and 14-methylaniline. The invention purpose is to provide the possibility to produce N-methyl-para-anisidine with purity at least 98% and high output that allows arrangement of highly profitable industry-scale manufacturing process.Type: GrantFiled: November 15, 2011Date of Patent: January 2, 2018Assignee: IFOTOP LIMITED LIABILITY COMPANYInventors: Yuriy Alexandrovich Ivanov, Alexander Yurievich Frolov, Nikolay Grigorievich Beliakov
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Patent number: 9856206Abstract: The present invention includes bis- and tris-benzamide compounds that block AR signaling and have anticancer activity. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.Type: GrantFiled: November 4, 2015Date of Patent: January 2, 2018Assignee: The Board of Regents of the University of Texas SystemInventors: Jung-Mo Ahn, Ganesh Raj
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Patent number: 9856207Abstract: The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy) benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methane sulfonic acid in high yields and very high enantiomeric and chemical purity in the form of the crystalline anhydrous polymorph identified as form A, wherein said salt is substantially free from impurities having genotoxic effect, such as (C1-C5)alkanylmethanesulfonates, and residual solvents known as potential precursors thereof, such as (C1-C5)alkanols or esters thereof with lower alkanoic acids.Type: GrantFiled: October 12, 2016Date of Patent: January 2, 2018Assignee: NEWRON PHARMACEUTICALS S.P.A.Inventors: Claudio Giordano, Erwin Waldvogel
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Patent number: 9856208Abstract: A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided.Type: GrantFiled: September 2, 2016Date of Patent: January 2, 2018Assignee: The Royal Institution for the advancement of Learning/McGill UniversityInventors: Jean-Philip Lumb, Kenneth V. N. Esguerra
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Patent number: 9856209Abstract: Xylylene dicarbamate contains impurities represented by formulas (1) to (4) below at a ratio of less than 100 ppm as a total amount thereof on a mass basis. (In the above-described formulas (1) to (4), R represents a monovalent hydrocarbon group.).Type: GrantFiled: January 19, 2017Date of Patent: January 2, 2018Assignee: MITSUI CHEMICALS, INC.Inventors: Koji Takamatsu, Hideki Sone, Masaaki Sasaki
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Patent number: 9856210Abstract: The present invention provides a prophylactic or therapeutic agent for amyotrophic lateral sclerosis, containing a 1,3-diphenylurea derivative or multikinase inhibitor.Type: GrantFiled: September 2, 2011Date of Patent: January 2, 2018Assignee: Kyoto UniversityInventors: Haruhisa Inoue, Shiho Kitaoka, Kayoko Tsukita, Ryosuke Takahashi, Gaku Murakami, Norio Nakatsuji, Motonari Uesugi, Yasuyuki Asai, Ayako Asai, Yuji Amagai, Kazuhiro Aiba
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Patent number: 9856211Abstract: This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N hydroxyl-3-(3-phenylsulfamoyl-phenyl)-acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine, and meglumine. The present invention also pertains to the use of such compositions, for example, in the inhibition of HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.Type: GrantFiled: August 5, 2014Date of Patent: January 2, 2018Assignee: Topotarget UK LimitedInventors: Richard J. Bastin, Nicholas J. Hughes
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Patent number: 9856212Abstract: The present disclosure relates to acaricide, specifically to a kind of biphenyl compounds and uses thereof. The general formula I is as follows: wherein: each substituent is defined as that in the description. The compounds of the general formula I show high acaricidal activities and can be used for controlling various harmful mites.Type: GrantFiled: April 18, 2017Date of Patent: January 2, 2018Assignee: Shenyang Sinochem Agrochemicals R&D Co., Ltd.Inventors: Lixin Zhang, Jing Zhang, Lanfeng Ban, Hongfei Wu, Yuquan Song, Haibo Yu, Peng Li, Jingbo Xu, Libao Xu
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Patent number: 9856213Abstract: The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl-group, optionally substituted with —ONO2 group, or an aralkyl- or aryl-group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl-group, Y represents (CH2)n group or O atom or S atom, and where n=0-3.Type: GrantFiled: December 10, 2015Date of Patent: January 2, 2018Assignee: CHINOIN ZRTInventors: Gábor Havasi, Tibor Kiss, Irén Hortobágyi, Zsuzsanna Kardos, István Lászlófi, Zoltán Bischof, Ádám Bódis
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Patent number: 9856214Abstract: The invention provides EBNA1 inhibitors, and pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The compounds and compositions of the invention are further useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. The compounds and compositions of the invention are further useful for the treatment of diseases caused by lytic EBV infection.Type: GrantFiled: November 14, 2014Date of Patent: January 2, 2018Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGYInventors: Troy E. Messick, Garry R. Smith, Allen B. Reitz, Paul M. Lieberman, Mark E. McDonnell, Yan Zhang, Venkata Velvadapu
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Patent number: 9856215Abstract: Disclosed is a preparation method of nintedanib (I), comprising the following steps: carrying out a condensation reaction on 4-(R acetate-2-yl)-3-nitrobenzoate (II) and trimethyl orthobenzoate to obtain (E)-4-[(2-methoxybenzylidene) R acetate-2-yl]-3-nitrobenzoate (III); carrying out a substitution reaction on the compound (EI) and N-(4-aminophenyl)-N-methyl-2-(4-methyl piperazine-1-yl) acetamide (IV) under the action of an acid-binding agent to generate (Z)-4-{[2-(N-methyl-2-(4-methyl piperazine-1-yl) acetamido-aniline) benzylidene] R acetate-2-yl}-3-nitrobenzoate (V); and sequentially carrying out reduction reactions and cyc-lization reactions on the compound (V) to prepare the nintedanib (I). The preparation method has an easily obtained raw material and a simple process, is economical and environmentally friendly, and is suitable for industrial production.Type: GrantFiled: March 8, 2017Date of Patent: January 2, 2018Assignee: SUZHOU MIRAPHARMA TECHNOLOGY CO., LTD.Inventor: Xuenong Xu
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Patent number: 9856216Abstract: Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKK? (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the compound according to the present invention effectively inhibits TNIK, IKK? and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.Type: GrantFiled: April 21, 2016Date of Patent: January 2, 2018Assignee: GREEN CROSS CORPORATIONInventors: Soongyu Choi, Eun-Jung Park, Hee Jeong Seo, Younggyu Kong, Ickhwan Son, Sang-ho Ma, Man-Young Cha, Mi-Soon Kim, Kisoo Park
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Patent number: 9856217Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.Type: GrantFiled: June 1, 2017Date of Patent: January 2, 2018Assignee: NEUROVANCE, INC.Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
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Patent number: 9856218Abstract: In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 15, 2014Date of Patent: January 2, 2018Inventors: Robert A. Baiocchi, Chenglong Li, Hongshan Lai, Said Sif