Abstract: The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptor-expressing cells through apoptosis. [Object] An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer. [Means for Resolution] A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: Anti-CD22 antibodies, including isolated nucleic acids that encode at least one such anti-CD22 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract: The present invention provides compositions for the production of an antibody or functional fragment thereof directed against disialoganglioside-GD2. The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to GD2. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: Described herein are methods for chemical modification of nitrocellulose to generate lyophobic properties which are useful in propellant compositions. Such methods include the steps of: a) dissolving neat nitrocellulose in an organic solvent; b) adding a silyl based isocyanate and a catalyst to the solution; (d) stirring the solution in a moisture free environment; e) hydrolyzing the solution by exposing said solution to moisture; and (e) adding fluorinated oxysilane. The modified nitrocellulose retains its energetic properties while exhibiting high water and organic solvent phobicity, effectively functioning as a barrier to migration or diffusion of liquid components in propellant compositions.

Abstract: In accordance with some embodiments of the present invention, a composite material is prepared by blending a flame retardant modified cellulosic nanomaterial (FR-CN) filler into a polymer, wherein the FR-CN filler comprises a cellulosic nanomaterial (e.g., cellulose nanocrystals (CNCs) and/or cellulose nanofibrils (CNFs)) having a surface functionalized to incorporate a phosphorus-containing moiety. In some embodiments, the FR-CN filler is prepared by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a halogenated phosphorous-containing monomer (e.g., diphenyl phosphoryl chloride). In some embodiments, the surface of the cellulosic nanomaterial is further functionalized to incorporate an orthogonal functionality selected to enhance the compatibility of the FR-CN filler with the polymer by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a monomer (e.g., epichlorohydrin when the polymer is an epoxy-based polymer).

Abstract: The present invention relates to a modified diene elastomer predominantly comprising a species coupled via a group bearing a function comprising a silicon atom predominantly hydrolyzed into silanol and a tertiary amine function, linked to the diene elastomer via the silicon atom, and to the process for synthesizing the modified diene elastomer. This elastomer has the particular feature of not undergoing any change in Mooney viscosity during its storage.

Abstract: A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports.

Abstract: Biomedical devices and methods are disclosed for the development of 3D polymeric scaffolds for cell culture, high throughput screens for biomolecule purification, and generation of bone mimetic materials. The devices may feature multiple geometries, and scaffold generation capabilities include multiple gel types utilizing organic and aqueous phase pregel. Additionally, macroporous and non-macroporous morphologies are possible.

Abstract: The present invention relates to: a polymerizable compound (I), wherein Y1 to Y6 are a chemical single bond, —O—C(?O)—, —C(?O)—O— or the like, G1 and G2 are a divalent aliphatic group, Z1 and Z2 are an alkenyl group, Ax is a fused ring group represented by a formula (II), wherein X is —NR3—, an oxygen atom, a sulfur atom or the like, R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and D is a substituted or unsubstituted ring having 1 to 20 carbon atoms that includes at least one nitrogen atom, Ay is a hydrogen atom, an alkyl group, A1 is a trivalent aromatic group or the like, A2 and A3 are a divalent aromatic group having 6 to 30 carbon atoms or the like, and Q1 is a hydrogen atom, or an alkyl group having 1 to 6 carbon atoms.

Abstract: Cross-linked cyclopolymeric resins from N,N-diallyl quaternary ammonium monomers and tetrallylpiperazinium cross-linking monomer or salts, solvates, tautomers or stereoisomers as adsorbent materials for the removal of heavy metals from aqueous solution. A process for producing the cross-linked cyclopolymeric resins by Butler cyclocopolymerization of the monomers with a free radical initiator. The cross linked cyclopolymeric resins are polyzwitterionic or polyzwitterionic and dianionic and feature repeating units with multiple chelating centers that heavy metal ions can bind to. In addition, a method for removing heavy metals from aqueous solution via contacting and treatment with the cross-linked cyclopolymeric resins.

Abstract: In one preferred embodiment, the present invention provides a process for the liquid phase polymerization of isobutylene to manufacture highly reactive PIB oligomers having Mn under 1000, using a catalyst composition comprising a Friedel-Crafts catalyst a complexing agent, a chain transfer agent and a polymerization-retarding agent. A chain transfer agent may be selected from: ?-DIB and ?-DIB and mixtures thereof.

Abstract: Novel tetracyanoanthraquinodimethane polymers and use thereof. The problem addressed was that of providing novel polymers which are preparable with a low level of complexity, with the possibility of controlled influence on the physicochemical properties thereof within wide limits in the course of synthesis, and which are usable as active media in electrical charge storage elements for high storage capacity, long lifetime and stable charging/discharging plateaus. Tetracyanoanthraquinodimethane polymers consisting of an oligomeric or polymeric compound of the general formula I have been found.

Abstract: The present invention relates to processes for polymerizing unsaturated hydrocarbon monomers. The present invention also relates to a precatalyst having the structure of Formula (I): M{C(SiHAlk2)3}3??(I), and to a catalyst comprising the structure of Formula (II): MC(SiHAlk2)3X2??(II), and methods for preparation thereof.

Abstract: The invention provides a high pressure, free-radical polymerization process for polymerizing an ethylene-based polymer, said process comprising polymerizing ethylene, in a reactor configuration comprising a reactor with at least two reaction zones, a first reaction zone and a reaction zone located downstream from the first reaction zone; and wherein CO (carbon monoxide) is added to the reactor in at least one reaction zone located downstream from the first reaction zone, and wherein, less than, or equal to, 95 weight percent of the total amount of CO, is fed to the first reaction zone.

Abstract: Methods for making olefin polymerization catalysts and methods for making polyethylene polymers using the catalysts are provided. The polyethylenes can have a molecular weight distribution (MWD) of about 4.5 to about 14, a slope of strain hardening greater than about 0.75, and a melt flow ratio (MFR) greater than or equal to 8.33+(4.17×MWD).

Abstract: To provide a photocurable fluorinated polymer composition which has a high curing rate, shows little shrinkage before and after photocuring and requires no post treatment such as heat treatment after photocuring and whereby it is possible to obtain a cured resin excellent in heat resistance and weather resistance. According to the photocurable fluorinated polymer composition comprising a fluorinated polymer (A) containing polymerized units derived from a fluoroolefin and polymerized units derived from an unsaturated monomer having an oxetanyl group or a substituted oxetanyl group, and a photoreaction initiator (B), of the present invention, it is possible to provide a photocurable fluorinated polymer composition which has a high curing rate, shows little shrinkage before and after photocuring and requires no post treatment such as heat treatment after photocuring and whereby it is possible to obtain a cured resin excellent in heat resistance and weather resistance.

Abstract: A polymer including a first repeating unit represented by Formula 1, a second repeating unit represented by Formula 2, and a third repeating unit: wherein R1 to R3, X, and Rf in Formula 1 and R4 to R6, R, and a in Formula 2 are the same as those defined in the detailed description, and wherein the polymer has a glass transition temperature of about 25° C. or less or a Young's modulus of about 10 megaPascals or greater.

Abstract: A copolymer comprising a structural unit (I) derived from a phosphonate monomer (1) such as diethyl methacryloyloxymethyl phosphonate, diethyl 2-methacryloyloxyethyl phosphonate and the like, and a structural unit (II) derived from a radical polymerizable monomer (2) such as methacrylic acid, acrylic acid, 8-tricyclo[5.2.1.02,6]decanyl methacrylate, t-butyl methacrylate and the like, wherein the content of phosphorus atoms from the phosphonate monomer (1) is 2.0 to 6.0% by mass relative to the mass of the copolymer. A formed article comprising the copolymer.

Abstract: Anhydrosugar-based monomers prepared from isosorbide, isomannide, and isoidide and resin systems containing these anhydrosugar-based monomers that are partially to fully bio-based, which may produce materials having properties that meet or exceed the properties of similar petroleum derived vinyl ester resins.

Abstract: The present disclosure provides a method for reducing the aldehyde content in an amine catalyst by treating the amine catalyst with an organic acid. The organic acid-treated amine catalyst may then be used in the production of polyurethane materials which exhibit reduced aldehyde emissions.

Abstract: The present method relates to the production of low viscosity dimethoxy amino silane polyurethane with triethoxy silyl groups, as well as the production of sealants, adhesive and paint compositions using the alcoxysilane capped polymers formed from the present method. The method of production results in final alcoxysilane capped polymers that have a low viscosity and are safer for manufacturers, and end users.

Abstract: A method of forming a lignin-based biomass epoxy resin is provided, which includes: (a) mixing a lignin, an acid anhydride compound, and a solvent to react for forming a first intermediate product, (b) reacting the first intermediate compound with a first polyol to form a second intermediate compound, and (c) reacting the second intermediate compound with an epoxy compound to form a lignin-based biomass epoxy resin.

Abstract: Provided is a curable composition that is rapidly cured to form a cured product. The cured product resists yellowing, successfully maintains excellent transparency over a long time even in a high-temperature environment, and is advantageously usable as or in a wafer-level lens. The curable composition according to the present invention includes a cycloaliphatic epoxide (A), a siloxane compound (B), and a curing agent (C). The cycloaliphatic epoxide (A) is represented by Formula (1). The siloxane compound (B) contains two or more glycidyl groups per molecule. In the formula, X is selected from a single bond and a linkage group.

Abstract: In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides bimetallic complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to one or more active metal centers of the complex.

Abstract: The present invention relates to a copolyamide comprising at least two units and corresponding to the following general formula: A/(diamine).(Cw diacid), in which: the diamine is a cycloaliphatic diamine, w represents the number of carbon atoms of the diacid, A is chosen from a unit obtained from an amino acid or from a lactam and a unit corresponding to the formula (Cx diamine).(Cy diacid), with x representing the number of carbon atoms of the diamine and y representing the number of carbon atoms of the diacid, and in which at least one of the monomers chosen from A and the Cw diacid is obtained, in all or part, from renewable starting materials according to Standard ASTM D6866. The invention also relates to a composition comprising this copolyamide and to the use of this copolyamide and of such a composition.

Abstract: The invention relates to a method and arrangement of crosslinking or vulcanizing an elongate element, the method including an extrusion step in which a conductor element is coated by a layer of crosslinkable synthetic material and a crosslinking step in which crosslinking reaction is carried out after the extrusion step. The crosslinking reaction is carried out at first in a first heating zone by heating by heating the coated conductor element in a temperature of 550 degrees Celsius or higher. The first heating zone is located downstream of the extrusion step. After the first heating zone the crosslinking reaction is carried further by heating the coated conductor in a temperature of 200-300 degrees Celsius in a second heating zone.

Abstract: The present invention relates to sizing compositions, to glass fibers at least partially coated with such sizing compositions, to a variety of fiber glass products at least partially coated with such sizing compositions, and to composites formed from cycloolefins and reinforced with glass fibers at least partially coated with sizing compositions of the present invention. In one non-limiting embodiment, a sizing composition for glass fibers comprises a film-former comprising a polymer, wherein the repeating unit of the polymer comprises at least four carbon atoms and at least one carbon-carbon double bond, and a silane.

Abstract: An optical film including a polymer including a repeating unit A including a repeating unit represented by the following Chemical Formulas 1 to 3, or a combination thereof; and a repeating unit B derived from a monomer having an unsaturated bond copolymerizable with the repeating unit A, wherein the optical film has a short wavelength dispersion of an in-plane phase-difference value (Re) (450 nm/550 nm) ranging from about 0.81 to about 1.20, and a long wavelength dispersion of an in-plane phase-difference value (Re) (650 nm/550 nm) ranging from about 0.90 to about 1.18: wherein, in Chemical Formulas 1 to 3, the variables R1 to R21 are defined herein.

Abstract: By completing curing in a short period of time even at low temperatures and using an epoxy resin composition as a matrix resin of a prepreg, it is possible to obtain a fiber-reinforced composite plastic product such as a fiber-reinforced tubular composite with excellent mechanical properties and, more particularly, excellent impact resistance. The epoxy resin composition includes A component, B component, C component, D component and E component, where the content rate of sulfur atoms is equal to or more than 0.2 wt % and equal to or less than 7 wt %, and the content rate of the C component is equal to or more than 1 wt % and equal to or less than 15 wt %. A component: epoxy resins, B component: reactive products of the epoxy resins and an amine compounds including the sulfur atom in a molecule (the unreacted epoxy resins and/or the amine compounds may be included), C component: polyamide compounds soluble in the A component, D component: urea compounds, and E component: dicyandiamide.

Abstract: Methods for preparing polyurethane flexible foam are described, wherein an organic polyisocyanate is reacted with an active hydrogen-containing component such as an organic polyol, in the presence of a urethane catalyst, a blowing agent, optionally a cell opener, and a siloxane-based surfactant composition as a stabilizer for the foam. The siloxane-based surfactant composition comprises a silanol-functionalized organosiloxane having general formula (I), wherein: the R groups are independently a C1-C3 alkyl, phenyl, or —OSi(R)3; provided that at least one R group is a hydroxyl (—OH) bonded directly to any silicon atom and X is an integer from 0-200.

Abstract: This present invention discloses a halogen-free flame retardant polyolefin foam composite, which is comprises: 80-125 parts by weight of ethylene/vinyl acetate copolymer (EVA), 8-13 parts by weight of high density polyethylene (HDPE) or low density polyethylene (LDPE), 15-25 parts by weight of polyolefin elastomer (POE), 60-77 parts by weight of acid source material, 17-22 parts by weight of carbon source material, 8-11 parts by weight of gas source material, 1-8 parts by weight of retardant synergist, 5.5-8 parts by weight of composite foaming agent, 0.7-1.0 parts by weight of crosslinking agent, 4.0-5.5 parts by weight of plasticizer, 0.5-1.6 parts by weight of surface treatment agent, 20-35 parts by weight of compatibility, 6-14 parts by weight of inorganic filler, and 1.6-4.6 parts by weight of additive.

Abstract: The present invention relates to a polyurethane resin composition for preparing a polyurethane composite, having (a) an organic polyisocyanate; (b) an isocyanate-reactive component having (b1) one or more polyether carbonate polyols which are prepared by addition of carbon dioxide and alkylene oxides onto starters having active hydrogen using DMC catalysts, and (b2) one or more polyols which have a functionality of 2-6 and are selected from polyether polyols, polyester polyols, polymer polyols or combinations thereof; and (c) a blowing agent having an amount of 0-0.2 wt. % based on 100% by weight of the isocyanate-reactive component (b).

Abstract: A process for the recycling of wastes from webs or strands made of prepreg wastes comprising a first reactive resin, having the following steps: homogenization of prepreg wastes, dispersion of fillers and/or additives in a second reactive resin, mixing of the second resin, homogenized prepreg wastes and further processing of the mixture of resin, fillers and/or additives and prepreg wastes to produce molded workpieces.

Abstract: A low viscosity polysulfide sealant composition. The composition comprises a curable polysulfide polymer; a crosslinking agent; and a plurality of core-shell particles. The core-shell particles comprise: a core comprising a ferromagnetic material; and a shell comprising silica treated with an organic sulfur containing compound. The shell is capable of bonding with the polysulfide polymer.

Abstract: A polymeric material formed by reacting aminopolyol having a structure: wherein R4 is selected from the group consisting of —H and —CH2—CH2—OH; and an organosilane, wherein said organosilane has a structure: wherein R1 is selected from the group consisting of —H, —CH3 and —CH2—CH3 and R2 is selected from the group consisting of —OH, —O—CH3, O—CH2—CH3, alkyl, alkyl with a chlorine moiety, alkyl with an amino moiety, and alkyl with a quaternary ammonium group.

Abstract: Provided are a surface-modified metal oxide particle dispersion liquid and the like including surface-modified metal oxide particles that are dispersed in a dispersion medium, the surface-modified metal oxide particles being obtained by modifying surfaces of metal oxide particles to have hydrosilyl groups, hydrophobic functional groups, and silanol groups. In the surface-modified metal oxide particle dispersion liquid, a ratio of the hydrosilyl groups to the silanol groups is 5:95 or higher and 50:50 or lower.

Abstract: Provided are a rubber composition for tires that shows a balanced improvement in properties such as fuel economy, processability, heat aging resistance, abrasion resistance, wet-grip performance, performance on snow and ice, and handling stability, and a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for tires, containing: a highly purified, modified natural rubber having a pH adjusted to 2 to 7, and a silica having a CTAB specific surface area of 180 m2/g or more and a BET specific surface area of 185 m2/g or more, and also relates to a pneumatic tire formed from the rubber composition.

Abstract: A process for making a colored composite pavement structure comprising silylated glass aggregate particles and a polymeric binder composition is disclosed. Systems and methods are also disclosed for providing a colored composite material that cures into a pavement structure. In one embodiment, a colorant concentrate is provided by combining an inorganic colorant with a portion of a first component of a polymeric binder composition. The colorant concentrate can then be combined with the first and second components of the polymeric binder composition to provide a colored polymeric binder composition. The colored polymeric binder composition may then be applied to silylated glass aggregate particles to provide a colored composite material that cures into a pavement structure.

Abstract: A composition includes a reversible polymer material, which can reversibly transition between a liquid state and a solid state by reversible cycloaddition reactions, wherein upon cooling, the reversible polymer material transitions from a liquid state to a solid state by reversible cycloaddition reactions, and a radical scavenger.

Abstract: The present invention relates to a thermoplastic composition that provides improved thermal aging stability along with durability. The thermoplastic composition comprises a polyamide resin, and a polyhydric alcohol, wherein a majority of the polyhydric alcohol particles have a particle size that is less than about 70 microns. It has been found that a combination of a polyamide resin and a polyhydric alcohol with this particle size produces a superior product demonstrating greater thermal stability and durability than the polyamide resin alone.

Abstract: Plastic compositions that include one or more plasticizers containing acylated phenolated fatty acid esters and methods for making same are provided. In some examples, the plastic composition can include a polymer and a plasticizer. The polymer can be or include a polyvinyl chloride, a polyvinylidene chloride, a cellulose ester, a cellulose ether, a cellulose nitrate, a polyacrylate, a polyurethane, a copolymer thereof, or any mixture thereof. The plasticizer can be or include an acylated phenolated fatty acid monoester, an acylated phenolated fatty acid diester, or a mixture thereof. The plastic composition can include the plasticizer in an amount of about 10 wt % to about 60 wt %, based on a combined weight of the polymer, any acylated phenolated fatty acid monoester, and any acylated phenolated fatty acid diester.

Abstract: An apparatus and a method are provided for a latex-based packaging material configured to provide a dust-free alternative to vermiculite packaging materials. The latex-based packaging material comprises a portion of a latex-based waste formulated into a recycled latex emulsion, and a portion of particulate material into which the recycled latex emulsion is mixed so as to form a latex-based pulp. In some embodiments, additional components, such as any of various plasticizers, coloring agents, or hardeners, may be included in the latex-base pulp. The latex-based pulp is dispensed and dried so as to form the latex-based packaging material in a variety of desired shapes. Drying may be accomplished by way of unaided atmospheric evaporation, or by way of various conventional drying methods. In some embodiments, the desired shape of the packaging material comprises latex-based packaging peanuts suitable for separating and cushioning forces between containers during transportation in a larger container.

Abstract: A sulfur-crosslinkable rubber mixture, in particular for pneumatic vehicle tires, straps, belts, and hoses, is disclosed which exhibits, among other things, improved rolling resistance behavior. The rubber mixture contains at least the following constituents: 5 to 95 phr of at least one styrene-butadiene rubber, which is functionalized with phthalocyanine groups and/or hydroxy groups and/or epoxy groups and/or silane-sulfide groups and the styrene content of which is 0 to 12 wt % and which has a glass transition temperature (Tg) according to DSC of ?75 to ?120° C. in the unvulcanized state, 5 to 95 phr of at least one further rubber, and 20 to 300 phr of at least one silica.

Abstract: The present invention relates to a composition comprising an aqueous dispersion of spheroidal particles having a mode particle size of from 10 to 30 ?m. The spheroidal particles are useful as organic extenders, especially in below-critical pigmented coatings formulations, and provide coatings with improved stain removal properties.

Abstract: A composite comprising polypropylene and a filler, which comprises asphaltenes extracted from Arabian Heavy crude oil. The composite comprises 90-98 wt % of the polypropylene polymer and 2 wt % to less than 10 wt % of the filler, where the weight percentages are based on a total weight of the composite. A melt-blending method is used to prepare the composites. A material comprising the composite is disclosed.