Abstract: A tibial, prosthesis, and, particularly, a fixed bearing tibial, prosthesis has a two-pronged securement mechanism. The securement mechanism may or may not be angled. Advantageously, the securement mechanism, working alone or in cooperation with other securement features, minimizes micromotion between the tibial tray and tibial hearing component.

Abstract: An orthopaedic tibial prosthesis includes a tibial baseplate with features designed for use with small-stature knee-replacement patients. The tibial prosthesis may include a shortened tibial keel, tibial keel fins which define a large angle with respect to a longitudinal axis of the keel, and/or tibial keel fins which extend along less than the entire longitudinal extent of the keel.

Abstract: Expandable prosthetic devices used for treating a variety of conditions, including rotator cuff injuries, broken and/or depressed bone fractures, infection and/or inflammation in the body. In one embodiment, a prosthesis includes an implant having a pressure regulating valve. The implant is capable of being positioned between a first tissue and an opposing second tissue in a void space and of deforming under pressure in response to articulation of a joint. The pressure regulating valve is configured to open based on a predetermined pressure in the implant.

Abstract: Systems and methods are described for correcting sagittal imbalance in a spine including instruments for performing the controlled release of the anterior longitudinal ligament through a lateral access corridor and hyper-lordotic lateral implants.

Abstract: An expandable interspinous spacer implant that is configured to be inserted into an interspinous space that is defined between a spinous process of a superior vertebral body and a spinous process of an inferior vertebral body is provided. The implant may include a superior housing, an inferior housing, and a distracting member. The superior housing may have an outer surface that is configured to engage the spinous process of the superior vertebral body and the inferior housing may have an outer surface that is configured to engage the spinous process of the inferior vertebral body. The distracting member may be disposed between the superior and inferior housings, such that activation of the distracting member distracts the superior and inferior housings apart from each other.

Abstract: The present invention provides an expandable fusion device capable of being inserted between adjacent vertebrae to facilitate the fusion process. The expandable fusion device may include first and second endplates, a translation member configured to expand an anterior side and/or posterior side of the device, a plurality of joists configured to connect the first and second endplates to the translation member, and first and second actuation members disposed internally to the device such that openings on a back side of the device can be used to expand or compress the anterior side, the posterior side, or both and such openings may also be used to introduce graft material into the device.

Abstract: An intervertebral implant frame that is configured to engage a spacer can include a pair of arms that extend longitudinally from a support member such that the arms engage the spacer. The spacer can be made from bone graft, and include a first spacer body made of cortical bone, and a second spacer body made of cancellous bone.

Abstract: A method for treating a spine is provided. The method includes the steps of: disposing an interbody implant adjacent a first vertebral surface and a second vertebral surface of an intervertebral disc space, the interbody implant engaging the vertebral surfaces at a selected angular orientation; connecting the interbody implant with at least one of the vertebral surfaces via at least one fastener that is engaged with the interbody implant and fixed with the vertebral surface such that the at least one fastener is movable to a plurality of axial orientations relative to the interbody implant; and manipulating the vertebral surfaces such that the at least one fastener is fixed relative to the interbody implant. Spinal implants, surgical instruments and systems are disclosed.

Abstract: The present invention provides an expandable fusion device capable of being inserted between adjacent vertebrae to facilitate the fusion process. A method of installing an expandable fusion device may comprise introducing the expandable fusion device into an intervertebral space, wherein the expandable fusion device comprises a proximal end, a distal end, an anterior side connecting the proximal end and the distal end, and a posterior side connecting the proximal end and the distal end, wherein the expandable fusion device has an anterior height on the anterior side and a posterior height on the posterior side. The method may further comprise adjusting the anterior height of the expandable fusion device independently from adjustment of the posterior height. The method can also include changing the lordotic angle.

Abstract: An intervertebral implant can include a core and a flexible end plate. The core can have a core body that is elongate along a first direction and defines first and second outer surfaces. The flexible end plate can define an inner surface and an opposed bone facing surface that is configured to abut a vertebral body. The flexible end plate can be coupled to the core such that at least a portion of the inner surface faces the first outer surface and is spaced from the first outer surface. The flexible end plate is configured to resiliently flex toward a compressed configuration such that as the flexible end plate flexes toward the compressed configuration, a first end moves relative to the core along the first direction and the portion of the inner surface moves toward the first outer surface.

Abstract: Apparatus and methods for lumbar fusion. An apparatus includes a large footprint interbody cage, a two bladed mini-open retractor, and a pole, the large footprint interbody cage laid into a concavity forward by outwardly bent tines of the two bladed mini-open retractor, the pole for impacting the large footprint interbody cage into an interbody space advanced through a stab incision separate from a main incision and attached to the large footprint interbody cage.

Abstract: The present disclosure provides a provisional tibial prosthesis system for a set of prosthetic knee joints for implantation in a natural knee, the provisional tibial prosthesis system including a bearing component and a bearing support, the spacing of the bearing component from the bearing support is adjustable to allow for representation of a variety of different sized final tibial prostheses. In this system, only one provisional bearing component corresponding to each level of constraint is needed and shims are used to adjust the spacing of the bearing component from the beating support. The shims are slidably insertable between the bearing component and the bearing support in an anterior/posterior direction to allow for adjustment of the spacing of the bearing component from the bearing support. The number of provisional components needed during knee surgery is reduced and adjustment of the system only requires the knee joint to be distracted by a distance equal to the height of a particular shim.

Abstract: A system and method are provided for electronically capturing a subject's anatomy comprising an electronic device with a camera, display screen, and end-user software program to interface with the user. The software program tracks a target placed in view area, and gives visual feedback to the user based on target tracking. The software program includes criteria represented visually, via audio feedback, or haptic feedback, to the user indicating how to position the camera relative to the anatomy. The end-user software program may have means to automatically capture anatomy on the electronic device based on the criteria being met. The end-user software program may have means to electronically transmit the anatomical information to a remote location where said information can be used to build a custom orthotic device. The system may also have the means to detect and distinguish anatomic contours from other objects in the view area.

Abstract: A prosthetic system includes a prosthetic knee having a controller and a hydraulic unit pivotally connected to the controller. The hydraulic includes a reserve hydraulic cylinder, a brake hydraulic cylinder, and a hydraulic cylinder having a lower hydraulic compartment. A flow system fluidly connects the hydraulic cylinder, the reserve hydraulic cylinder, and the brake cylinder. The flow system has first and second flow paths in communication with the lower hydraulic compartment and the reserve hydraulic cylinder. The first flow path is in communication with lower hydraulic compartment and the reserve hydraulic cylinder via the brake cylinder. The second flow path bypasses the brake hydraulic cylinder.

Abstract: A prosthetic socket for a residual limb of the lower extremity or upper extremity of an individual person is provided. The residual limb has particular dimensions and anatomical contours; the prosthetic socket has dimensions and contours that fit the dimensions and contours of the residual limb. The prosthetic socket may also fit in a manner that is biomechanically appropriate for the individual. The prosthetic socket may be an assembly from groups of components that include (a) struts arranged longitudinally with respect to the residual limb, (b) proximal brim members arranged proximally to the struts and connected thereto; and (c) distal socket members disposed at the distal base of the prosthetic socket. The socket components within these groups may be modular in that they can vary with respect to dimensions and/or contours, and yet have common connecting features that permit assembly of the components together to form the prosthetic socket.

Abstract: Barrett's esophagus is a serious complication of GERD. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells (which are usually found lower in the gastrointestinal tract). A method comprising deploying multiple stents to cause pressure ischemia and subsequent necrosis of the mucosal layer of the esophagus which is affected with the Barrett's disease is disclosed. A pair of implantable stents having specific characteristics is disclosed which can be deployed in the esophagus to cause necrosis of the mucosal layer of the esophagus through induction pressure.

Abstract: A stent design reduces the likelihood of contact among structural members when the stent diameter is reduced before insertion into the body. In one approach, an undulating link has a J-shaped profile or has an angled portion on one side at the peak of the link, in order to reduce contact during crimping. The stent may also include structural features that improve such aspects as flexibility, the coatibility of a drug coating onto the stent, flare reduction, stent retention within the body and/or reduction of the minimum diameter of the stent during crimping.

Abstract: An endoluminal stent (100) is described herein. In an embodiment, the endoluminal stent (100) includes a plurality of sinusoidal-shaped expandable ringlets (102) provided in parallel to form a tubular structure of the endoluminal stent (100). Further, adjacent ringlets (102) can be connected to each other by one or more asymmetrical offset connectors (108), the offset connectors (108) being non-linear in structure.

Abstract: A delivery device can provide sequential delivery of a plurality of intraluminal devices held in a compressed state on the delivery device. Delivery platforms on the delivery device can hold an intraluminal device in a compressed position and be positioned between pusher bands that may also be radiopaque markers. A post deployment dilation device can be included. The post deployment dilation device can be a plurality of expansion filaments, a bellows, or a balloon. An intravascular device deployment method can include allowing a self-expanding intravascular device to expand, aligning the post deployment dilation device under the intravascular device, and causing the post deployment dilation device to expand radially to push outward on the intravascular device.

Abstract: Stent delivery device including an inner member having a distal tip, a stent support member, and a stent disposed over a stent receiving region of the stent support member. An elongated outer sheath is slidably disposed over the inner member and the stent. The stent delivery device includes a distal junction removably coupling the distal end of the outer sheath to the distal tip, where the distal junction is actuatable to decouple the outer sheath from the distal tip. The stent delivery device includes a proximal junction removably coupling a distal portion of the outer sheath to a proximal portion of the outer sheath, where the proximal junction is actuatable to decouple the distal portion of the outer sheath from the proximal portion of the outer sheath. The distal and proximal junctions may be separately actuatable by rotating the inner member relative to the proximal portion of the outer sheath.

Abstract: A gastrointestinal implant device (2800) comprises a planar proximal element (220) configured to reside in a stomach to resist distal migration, a distal element (222) configured to reside in an intestine to resist proximal migration and one or more tethers (224) coupling the planar proximal element to the distal element.

Abstract: Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

Abstract: An orthopedic device includes a hinge assembly, a frame having first and second frame components spaced apart from and connected to one another by the hinge assembly, a strap system extending between medial and lateral sides of the first frame component, and at least one tensioning element. The at least one tensioning element has a first end secured to the strap system and a second end coupled to the hinge assembly. Articulation of the hinge assembly pulls the strap system toward the frontal plane by the at least one tensioning element.

Abstract: Disclosed herein is a digit protector device for a foot, toe, hand, and/or finger, which digit protector device, in one embodiment, can be inserted or embedded in the plaster cast for a hand or foot, wrapped into a hand or foot splint bandage, or inserted in an orthopaedic hand or foot brace, boot, or sandal.

Abstract: An adjustable neck brace is provided, including: a neck collar, including a sliding engaging groove, the sliding engaging groove extending in an extension direction and having a first engaging portion; a single positioning mechanism, attached to the neck collar and movable along the sliding engaging groove, having a second engaging portion, the second engaging portion being releasably positioningly engaged with the first engaging portion; a chin support, relatively movably connected to the neck collar; at least one connecting member, connecting the positioning mechanism and the chin support.

Abstract: An inflatable splint can include a sleeve shaped to conform to a specific human body part and a plurality of inflatable chambers disposed on the sleeve. The sleeve, in cooperation with the plurality of chambers in an inflated condition, can be contoured to maintain the specific human body part in a desired position. A method of using an inflatable splint includes admitting a body part into a sleeve of the inflatable splint and positioning the sleeve around the body part One or more of the plurality of air chambers are selectively inflated such that the flexible sleeve in cooperation with the plurality of chambers in inflated condition is contoured and positioned to maintain the specific human body part in a desired position.

Abstract: A particle filled neck brace is used for immobilizing the neck and chin of a patient and includes a vacuum pump disposed on the neck brace, which pump is communicated to the interior of the neck brace. After the neck brace is secured around the neck and chin of the patient, the vacuum pump is manipulated to remove air from the neck brace to form a rigid mold about the patient's neck and chin. The vacuum pump has a one way directional valve so that the neck brace remains in a rigid configuration for as long as the neck brace is applied to the patient. The neck brace also specifically forms a rigid mold over the patient's chin so as to immobilize the patient as well as to provide a comfortable fit without inducing further distracting the patient or restricting the patient's venous return blood flow.

Abstract: An ostomy device for attachment (coupling) to a base plate is disclosed. The ostomy device comprises attachment structures for attachment to a base plate, wherein the ostomy device comprises an attachment ring configured to be detachably attached to the base plate. The ostomy device comprises additional structures provided with attachment elements configured to be detachably attached to the attachment ring. The attachment ring is configured to be detachably attached to the inner side of an attachment recess provided in the locking flange of the base plate.

Abstract: Oral appliances, and systems and methods, which include oral appliances are described herein. An example oral appliance device for treatment of a sleep disorder or condition in a subject can include an upper portion configured to receive at least one maxillary tooth of the subject, and a lower portion configured to receive at least one mandibular tooth of the subject. The upper and lower portions are engageable such that the portions maintain a restricted orientation relative to each other when engaged, and the engaged restricted orientation is configured to maintain the mandible of the subject in a predetermined clinically beneficial orientation relative to the maxilla.

Abstract: A dental appliance is provided. The dental appliance includes a dental form configured to receive a portion of a dental arch of an individual, and an adhesive strip comprising a first side and a second side. The first side of the adhesive strip is attached to a portion of the dental form. The second side of the adhesive strip comprises a mucoadhesive configured to adhere the adhesive strip to a tongue of the individual such that the tongue of the individual can be selectively attached to the dental appliance.

Abstract: A tongue grasping and restraining device holds the tongue securely during sleep in order to minimize the risk of the tongue slipping back and blocking the throat, a condition known as obstructive sleep apnea. Plural tongue gripping projections are coupled to upper and lower supports. The projections engage and hold the tongue. One or more of the upper and lower supports are biased together into a tongue engaging position. A tongue depressor can extend rearwardly and downwardly from the upper support to depress the user's tongue to further open the user's airway. The position of the tongue depressor can be adjustable. The upper support is coupled to the user's upper jaw, for example, to a denture, dental appliance or other form of an upper jaw coupler and can be pivoted thereto. The lower support can be hinged to, fixed to, or otherwise joined to a lower jaw coupler. A tube and rod mechanism in one embodiment couples the upper and lower jaw couplers together.

Abstract: A condom is configured to include a space such that a front glans part of the condom does not excessively come into contact with the penis of a man by selecting a material having moderate elasticity such as soft synthetic resin or synthetic latex rubber or a foamed rubber material conforming thereto or the like for the front part of the condom made from a soft rubber material; and includes embossed sponge layers or fine soft hairs additionally laminated on the inside and outside of the condom, to provide an excellent moisturizing effect such that an excellent contraceptive effect and a sexual pleasure-increasing effect can be simultaneously obtained when a user wears the condom, thereby providing multiple effects such as contributing to the treatment of patients with chronic dyspareunia or patients with anorgasmia and the like.

Abstract: A method for monitoring an environment for a patient on a patient support device can include: receiving a temperature reading from a wireless sensor coupled to a body of the patient; comparing the temperature reading to air flowing through an airflow system associated with the patient support device; and modifying the air flowing through the airflow system.

Abstract: Temperature control device for use in fluid-based hyper/hypothermia systems, comprising a connection unit for connecting the device to a local power network, and a fluid temperature control unit for heating or cooling a fluid. The device includes a power supply unit, by which electrical consuming components of the fluid temperature control unit are supplied with power, and which effects supply of the electrical consuming components with direct current.

Abstract: At least some aspects of the present disclosure feature a combination, comprising: a garment, a configurable convective device, and an attachment device configured to attach the configurable convective device to the garment. The configurable convective device comprises a pneumatic structure having a first portion, a second portion, and an inflatable channel connecting the first portion and the second portion and at least one opening into the pneumatic structure. In some cases, the relative positions of the first portion and the second portion of the pneumatic structure can be rearranged.

Abstract: A therapy pack system provides a reusable self-adhering therapy pack to skin. The therapy pack may be for example, an ice pack, heat pack or hot and cold pack. A sticky polymer gel is mounted onto a polymer casing of the therapy pack. The polymer gel is re-usable to attach the therapy pack to a user's skin at the site needing therapy. The polymer gel also buffers the skin from heat or freezer burn associated with applying a hot/cold pack to skin for an extended period. A chloride based compound may be added to the polymer gel to prevent the gel from freezing. In some embodiments, a non-woven fabric patch may support the polymer gel adhesive providing an additional layer of protection to the skin while simultaneously allowing the gel to self-adhere the therapy pack to the user.

Abstract: A portable moxibustion therapy device includes a main body 20, having a top opening 21, a sidewall 22 and a bottom 23, and the sidewall 22 comprises a plurality of holes 24 on the sidewall 22 of the main body 20; a cover 30 for opening and closing the top opening 21 of the main body 20; a moxa container 40 which is substantially cylindrical and made of yellow soil in the main body 20; a cylindrical support 50 made of yellow soil placed the moxa container 40 blow in the main body 20; and a gauze 60 located between the moxa container 40 and the cylindrical support 50 in the main body 20. The portable moxibustion therapy device includes a plurality of holes to supply air or oxygen to the moxa 90.

Abstract: Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. The treatment probe may have an elongate body with a contact surface at a distal end of the elongate body. A treatment fiber or light source may be housed in the treatment probe and may be configured to direct treatment energy from the contact surface. The contact surface may be configured to couple to a surface of the eye to deliver the energy into the target area. In many embodiments the contact surface may have a convex configuration with a rounded outer shape and edge that facilitates the sweeping of the probe surface across the eye during treatment delivery. In some embodiments the probe may be swept in arc motions while delivering treatment energy to the eye.

Abstract: Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment.

Abstract: Methods and kits for treating or preventing an eye condition or for cleaning an eye area tissue are provided. A method of the invention includes administering an isoprenoidal essential oil to eye area tissue, chafing eye area tissue with an abrasive, and removing the abrasive. A kit according to the invention includes an isoprenoidal essential oil, an abrasive for chafing eye area tissue, and in instruction for use for treating an eye condition or cleansing an eye area tissue. The invention also includes a composition of matter comprising an isoprenoidal essential oil and a plurality of abrasive particles in ophthamologically acceptable base.

Abstract: A vacuum device comprises a vacuum generator and a vacuum interface for fluidically coupling the vacuum generator to a vacuum cavity for affixing an ophthalmological patient interface on a patient's eye. The vacuum device comprises a movement detector which is configured to detect movements of the patient's eye and a control unit that is configured to detect a faulty fluidic coupling of the vacuum cavity on the basis of a pressure that is ascertained by a coupled pressure sensor and to produce a control signal for interrupting an ophthalmological treatment that is carried out by an ophthalmological treatment device if an eye movement is detected by the movement detector at the same time as the detected faulty fluidic coupling of the vacuum cavity.

Abstract: Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed.

Abstract: An atraumatic microsurgical forceps may include an actuation structure, an actuation sleeve having an actuation sleeve distal end and an actuation sleeve proximal end, a surgical blank, and atraumatic forceps jaws of the surgical blank having atraumatic forceps jaws distal ends and atraumatic forceps jaws proximal ends. The surgical blank may be disposed within the actuation sleeve wherein at least a portion of the atraumatic forceps jaws extends from the actuation sleeve distal end. A compression of the actuation structure may be configured to gradually extend the actuation sleeve over the atraumatic forceps jaws proximal ends. An extension of the actuation sleeve over the atraumatic forceps jaws proximal ends may be configured to gradually close the atraumatic forceps jaws wherein the atraumatic forceps jaws initially contact at the atraumatic forceps jaws distal ends.

Abstract: A steerable laser probe may include a handle having a handle distal end and a handle proximal end, an actuation control of the handle, a housing tube having a housing tube distal end and a housing tube proximal end, a first housing tube portion having a first stiffness, a second housing tube portion having a second stiffness, an optic fiber disposed within an inner portion of the handle and the housing tube, and a cable disposed within the housing tube and the actuation control. A rotation of the actuation control may be configured to gradually curve the housing tube and the optic fiber. A rotation of the actuation control may be configured to gradually straighten the housing tube and the optic fiber.

Abstract: A reusable laser probe with single-use optic fiber may include a reusable handle, an optic fiber fixture, and a single-use optic fiber. The single-use optic fiber may include an optic fiber having an optic fiber distal end and an optic fiber proximal end. The optic fiber may be disposed in a first transitory connector having a first transitory connector distal end and a first transitory connector proximal end wherein the optic fiber distal end extends a fixed distance from the transitory connector distal end. The optic fiber may be disposed in a second transitory connector having a second transitory connector distal end and a second transitory connector proximal end wherein the optic fiber proximal end extends a fixed distance from the second transitory connector distal end. The first transitory connector may be inserted in the reusable handle and the second transitory connector may be inserted in the optic fiber fixture.

Abstract: An ophthalmic system may comprise an imaging device having a field of view oriented toward the eye of the patient; a patient interface housing defining a passage therethrough, having a distal end coupled to one or more seals configured to be directly engaged with one or more surfaces of the eye of the patient, and wherein the proximal end is configured to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through the passage; and two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to predetermined geometric markers on the eye of the patient which may also be imaged by the imaging device.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incisions to form a top lenticular incision, a bottom lenticular incision of a lens in the subject's eye, an added shape between the top and bottom incisions where the added shape has no corrective power and a transition ring bisecting both the top and bottom lenticular incisions.

Abstract: Anti-fog, interchangeable-lens goggle adapted for use with a battery comprising: a body with a flexible posterior portion for engaging a user's face and an anterior portion; a lens having a resistive anti-fog element thereon, the lens adapted for engaging the anterior portion of the body; an engagement mechanism for releasably interconnecting the lens and the body; an interconnection mechanism preferably protected by a tortuous path electrical interconnection system and depending from the body adapted for detachably interconnecting the heating element of the lens and the battery, the interconnection means operable or integral with the engagement mechanism such that interconnecting the heating element of the lens with the battery also reinforces interconnecting of the lens with the semi-rigid anterior portion of the body; and a strap adapted for holding the goggle on one of a user's head and helmet.

Abstract: The present invention provides an earcap and an earplug, the earcap has a shell made of a flexible material, the two ends of the shell are respectively provided with a sound inlet and a sound outlet, the interior of the shell is disposed in a through manner, a filter net is disposed at a position close to the sound outlet, in the shell. The earplug comprises an earcap and a filtering core mounted in the earcap, the earcap has a shell made of a flexible material, two ends of the shell are open, the two ends of the shell are respectively provided with a sound inlet and a sound outlet, the interior of the shell is disposed in a through manner, the filtering core is mounted between the sound inlet and the sound outlet, a filter net is disposed at a position close to the sound outlet, in the shell.

Abstract: A porous conduit may be suitable for use in treating a tissue site, and may include a central lumen and a porous wall positioned substantially concentric about the central lumen. The porous wall may have an open porous structure that may define a plurality of interconnected pores in fluid communication with one another. As part of a system, the porous conduit may be used with a manifold adapted to be positioned at a tissue site, a sealing drape adapted to cover the manifold to provide a sealed space relative to the tissue site, and a therapy device including a reduced-pressure source. The porous conduit may be disposed in the sealed space and in fluid communication between the sealed space and the reduced-pressure source.