Abstract: Composition for an acrylic bone cement for surgical or orthopedic use including a solid phase including a ternary mixture, consisting of a polymethyl methacrylate (or PMMA) homopolymer, a methyl methacrylate-styrene (or MMA-styrene) copolymer and a methacrylate-methyl acrylate (or MMA-MA) copolymer, and a liquid phase containing at least an acrylic monomer.

Abstract: The present invention discloses a method for producing the alpha-calcium sulfate hemihydrate bone graft, which comprises the following steps: mixing calcium sulfate dihydrate and deionized water to produce calcium sulfate dihydrate paste; stirring and heating the calcium sulfate dihydrate paste at least 160° C. within 100-350 psi to produce the conversion calcium sulfate hemihydrate, filtering the conversion calcium sulfate hemihydrate with high temperature to produce the filtered calcium sulfate hemihydrate, and washing the filtered calcium sulfate hemihydrate by absolute alcohol to get the alpha-calcium sulfate hemihydrate bone graft. The present invention does not use any catalyst, possesses a high purity, high mechanical strength, and good biocompatibility, facilitates bone growth and angiogenesis, requires only 31° C., the highest temperature, during the curing process. It makes the present invention more secure in the biomedical applications.

Abstract: The invention relates to electrospun three-dimensional (3D) nanofibrous scaffolds (with controllable porosities as high as about 96%) and methods of preparing the same. The electrospun 3D scaffolds possess interconnected and hierarchically structured pores with sizes ranging from tens of nanometers to hundreds of micrometers. In embodiments, the 3D scaffolds can be biocompatible and/or biodegradable. In some embodiments, the 3D scaffolds can be conductive. In some embodiments, the 3D scaffolds can contain bioactive species.

Abstract: A supramolecular polymer blend includes a thermoplastic elastomer functionalized with at least one bis-urea moiety and a functional component which is functionalized with at least one bis-urea moiety which is present in an amount of 0.5-40 wt % based on the total mass of the polymer blend. The functional component is selected from polyalkylene glycol, betaine, polysaccharide, zwitterion, polyol or taurine and derivatives thereof. Implants including the polymer blend and a process to manufacture the implants are also provided.

Abstract: The invention relates to self-assembled organosilane coatings for resorbable medical implant devices. The coatings can be prepared from coating compositions containing organosilane and can be applied to metal or metal alloy substrates. Prior to applying the coatings, the surfaces of the substrates can be pre-treated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be applied using various techniques and apparatus, more particularly, by a deep-coating process conducted at ambient conditions.

Abstract: The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.

Abstract: This invention concerns a biomimetic material based on energy-rich amorphous magnesium polyphosphate (Mg-polyP) microparticles that enhance cartilage synthesis and regeneration. One preferred formulation of the inventive material is a hyaluronic acid-Mg/Ca-polyP paste that can be produced from a water-soluble salt of polyP and water-soluble hyaluronic acid in the presence of water-insoluble/nearly insoluble calcium carbonate. Surprisingly, the inventor found that this cartilage-like material comprising amorphous Mg/Ca-polyP microparticles promotes the adhesion of chondrocytes and strongly upregulates the expression of the chondrocyte marker genes encoding alkaline phosphatase, collagen type 3A1, aggrecan and Sox9.

Abstract: A bone repairing material comprises a composition including an ?-calcium sulfate hemihydrate and an autologous bone powder, wherein the bone repairing material contains 20˜60 weight percent of the autologous bone powder and 40˜80 weight percent of the ?-calcium sulfate hemihydrate. The bone repairing material has a particle size in the range of 50˜1,000 ?m. A method for producing the bone repairing material comprises the following steps: producing the ?-calcium sulfate hemihydrate from a calcium sulfate dihydrate by microwave heating; grinding an autologous bone for generating the autologous bone powder; and, mixing the ?-calcium sulfate hemihydrate and the autologous bone powder to form the bone repairing material.

Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.

Abstract: Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-?-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.

Abstract: The present disclosure generally relates to implantable devices including a releasable nitrite ion and to methods of preparing and using such compositions and devices. In one embodiment, the device is a stent, for example, a vascular stent. In another embodiment, the nitrite ion is ionically bound to an inorganic ion.

Abstract: An incontinence aid may include a pad body. The pad body may include a liquid receiving area. The incontinence aid may further include a liquid passage connected to the pad body. The liquid passage may form a boundary about a majority of the liquid receiving area. The liquid passage may include at least one lateral opening facing the liquid receiving area.

Abstract: A blood filter device having an iron-chelating molecule, a haem-binding molecule and a haemoglobin-binding molecule bound to a support. Use of the device in a vessel containing blood, for example a blood bag or a flow line, removes haemolysis-derived components from the blood.

Abstract: The invention relates to a motor with a stator (2, 2?) and a rotor (1, 1?), which can be driven about an axial direction (4). The invention is characterized in that at least one of the stator and the rotor, in particular the stator, which has a winding arrangement that can be supplied with a current, can be radially compressed and expanded.

Abstract: The present disclosure provides for a method, control device, and implantable system, for acquiring a plurality of flow rate data points over time, each data point indicative of a flow rate of blood through the pump, calculating, based on the plurality of acquired flow rate data points, a value characterizing one or more features of a waveform formed from the plurality of flow rate data points; and determining, based on the value, the presence or absence of a suction condition in the pump.

Abstract: A system for cleaning an implanted blood pump, comprising: an inflow catheter having an expandable inflow member positioned about the periphery thereof; an inflow tube coupled with the inflow catheter; a valve assembly coupled to the inflow tube; an outflow tube coupled to the valve assembly; and an outflow catheter having an expandable outflow member positioned about the periphery thereof, the outflow catheter being coupled to the outflow tube. In use, the inflow tube and outflow tube extend through the skin of a human body, the inflow catheter and outflow catheter are positioned within the human body, and the valve assembly is positioned outside the human body.

Abstract: A display device for a medical apparatus including a projection surface arranged on the medical apparatus and configured to present a predetermined display content in a way visible to a user of the medical apparatus, and a projection device arranged on the medical apparatus and configured to project the predetermined display content from a rear side of the projection surface onto the projection surface. The projection surface and the projection device are configured as a head-up display unit for visual field presentation of the display content, and the medical apparatus may be an apparatus for carrying out extracorporeal blood treatment including the display device.

Abstract: The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing.

Abstract: A packaging body is configured to house a prefilled syringe that comprises an outer cylinder fillable with a liquid and a plunger movable with respect to the outer cylinder. The packaging body includes a container comprising a housing portion configured to house the prefilled syringe. The housing portion is configured to house the prefilled syringes with various protrusion lengths of the plungers from the outer cylinders, and comprises a first regulating portion that regulates movement of the plunger in a distal end direction in a housed state in which the prefilled syringe is housed in the housing portion.

Abstract: A method for pairing a portable device with a medical device can include displaying an association code on a dynamic display of the medical device and determining whether the portable device is positioned relative to the medical device within a predetermined range of positioning parameters. If the portable device is positioned relative to the medical device within the predetermined range of positioning parameters, the method can include optically reading the association code from the dynamic display of the medical device with the portable device. Only if the portable device is positioned relative to the medical device within the predetermined range of positioning parameters, and the association code is optically read from the dynamic display of the medical device with the portable device, then the method can include pairing the portable and medical devices such that the medical device responds to commands sent from the portable device to the medical device.

Abstract: There are disclosed devices and methods for protecting a user from a sharp tip of a medical needle. In an embodiment, a device includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a hook-and-loop fastening system disposed on at least one of the wings, and configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. In another embodiment, a method includes withdrawing a sharp tip of a medical needle from a patient, closing a pair of wings with the medical needle positioned between the wings, and fastening the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: A drip chamber for an infusion tube, including: a first end including a drip tube; a second end including an exit port; and a wall connecting the first and second ends and including an interior surface with a hydrophobic portion. The drip chamber includes a space enclosed by the interior wall and the first and second ends. The hydrophobic portion of the interior surface repels liquid contacting the hydrophobic coating. The hydrophobic portion of the interior surface enables light to refract through the hydrophobic portion and the wall in the same manner as is the case when the hydrophobic portion is not present on the interior surface.

Abstract: Provided is a medical pump for achieving continuous administration of a medicine by performing sequential driving with another medical pump. The medical pump includes: a pump driving unit for administering the medicine in accordance with a setting; a communication unit for performing communication between the other medical pump; a control unit for controlling individual driving of the pump driving unit and the communication unit; and an operation unit connected to the control unit. In a single administration period, the control unit judges a timing of starting cooperative administration of simultaneously driving the pump driving unit together with a pump driving unit of the other medical pump on the basis of the setting and on the basis of an input from the operation unit.

Abstract: A liquid medicine administration device for administration of a liquid medicine includes a liquid delivery unit; a control unit configured to control the liquid delivery unit; an activity detection unit; a storage unit configured to store data indicating an amount of the liquid medicine that has already been delivered into the living body; and a calculation unit configured to calculate a residual amount of the liquid medicine in the living body on the basis of (i) the data indicating the amount of the liquid medicine that has already been delivered by the liquid delivery unit into the living body, and (ii) the activity detected by the activity detection unit, and calculate a scheduled delivery amount of the liquid medicine to be administered into the living body on the basis of the residual amount of the liquid medicine.

Abstract: The present invention provides an injection pen system comprising of a driver assembly for a drug container; a syringe assembly; a power source for generating electrical energy; electrical communication means in each of the driver assembly and syringe assembly wherein the driver assembly and syringe assembly are in electrical communication; and at least one microprocessor programmed to monitor electrical signals produced by the injection pen components. The electrical signals may be produced at predefined intervals and they may be wirelessly transmitted. The transmitted signals may trigger commands within a computer program monitoring the injection process. The computer program may be spaced from the injection and driver assemblies. The injection pen system may incorporate a two-way switch activated by a trigger initiated by pulling a cap from a primary drug container or pushing the drug container adjacent a subject. The activation may cause the mixing of a lyophilised substrate with a fluid for injection.

Abstract: Systems and methods for measuring and damping forces within autoinjectors in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an injection system comprises a syringe disposed within a housing, the syringe having a first end and a second end; a needle disposed at the second end of the syringe; a plunger disposed at the first end of the syringe and configured to move toward the second end of the syringe; a stopper disposed between the plunger and the second end of the syringe; a first damper disposed between the plunger and the stopper, such that the first damper is capable of damping a first event occurring between the plunger and the stopper; and a second damper disposed at the second end of the syringe, such that the second damper is capable of damping a second event occurring at the second end of the syringe.

Abstract: The present invention relates to a prefilled plastic container, such as a plastic syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled plastic container is stable for a prolonged time period. Furthermore, the present invention relates to a kit comprising the prefilled plastic container, and to the use of the prefilled plastic container for therapeutic and cosmetic purposes.

Abstract: An injection device includes a housing for receiving a syringe or cartridge for containing a medicament; a rotary driveshaft mounted for rotation relative to the housing; and an elongate coiled torsion spring having respective formations at opposite ends thereof, with a first formation being anchored in a seat on the rotary drive shaft and a second formation being anchored in a seat on a reaction component. In use relative rotation of the rotary driveshaft and the reaction component in one angular direction strains the torsion drive spring, and release of the strained torsion drive spring causes expression of medicament from the syringe or cartridge. The torsion spring is longitudinally resiliently compressible between its end formations whereby during assembly of the injection device, the torsion spring may be longitudinally compressed and then rotated, thereby urging the end formations of the torsion drive spring into engagement with the respective seats.

Abstract: For a plunger for a syringe, particularly an injection syringe, which comprises a hollow body receiving the plunger, comprising a plunger head for fluid dense limiting a fluid chamber of the syringe, and a piston rod fixed to the plunger head with an actuation section, at which the plunger can be actuated for inserting into the hollow body, wherein the piston rod is formed by several longitudinally extending axial webs that comprise an outwardly radial extension rK from the longitudinal axis and lead into a common crossing section, which receives the longitudinal axis, wherein at least one free activation edge, which radially protrudes the radial extension rK, is provided on the piston rod, which when inserting the plunger, is engageable with a vibration activator of the hollow body such that an acoustic signal is emitted, it is intended, that a swinging arm body arranged between two axial webs couples the activation edge with the crossing section such that in case of a vibration activation in an axial direct

Abstract: A multi-dose medicament delivery device is presented having a housing, a medicament container assembly, a dose drum, a plunger rod, and an activation assembly. The dose drum is supported in the housing via a threaded connection, wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered, and axially movable with respect to the housing in a forward direction from said dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set. The plunger rod is operationally associated with the stopper and supported in the housing via a threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction.

Abstract: An injection needle assembly includes: a needle tube, a needle hub which holds the needle tube, a protector, a biasing member, a retaining member, and a restriction mechanism. The protector is movable between a first position at which the needle tip of the needle tube is covered and a second position at which the needle tip of the needle tube is exposed, the protector comprising an abutment piece. The restriction mechanism is configured such that, after the protector has moved from the first position to the second position and has further returned from the second position to the first position, the restriction member restricts the protector from moving from the first position to the second position again.

Abstract: A syringe cap is configured to be removably attached to a barrel to seal a needle hole in a puncture needle held by a barrel tip portion of the barrel, and comprises a first member that is configured to be pierced with the puncture needle and that comprises an elastic material having a Young's modulus in the range of 1 to 10 MPa; and a second member that comprises an elastic hollow body having a Young's modulus in the range of 1 to 10 MPa and that is configured form a closed space between the first member and the barrel. A vapor permeability of a material from which the first member is formed is lower than a vapor permeability of a material from which the second member is formed.

Abstract: An injection needle assembly includes a needle tube, a needle hub, a main body portion, a connecting portion, and an biasing portion. The main body portion is configured to move between a first position in which the needle tip of the needle tube is exposed and a second position in which the main body portion covers the needle tip of the needle tube.

Abstract: An injection needle assembly includes a needle tube, a needle hub configured to hold the needle tube, a protector, a biasing member, and a restriction mechanism. The restriction mechanism is configured such that, after the protector has moved from the first position to the second position and has further returned from the second position to the first position, the restriction member restricts the protector from moving from the first position to the second position again. At least a portion of the biasing member is disposed on a needle tip side of the restriction mechanism in the axial direction.

Abstract: A protection device is attachable to a syringe that includes a needle. The protection device includes an inner cylinder having a cam structure with at least one protrusion; an outer cylinder that covers the inner cylinder and the needle; and a spring. The outer cylinder has a guiding path structure including at least one guiding path. The guiding path structure includes an elastic member allowing the cam structure to move; and an inner edge provided at a position in a peripheral wall of the outer cylinder different from the elastic member. The inner edge is configured to regulate movement of the cam structure by engaging with the cam structure.

Abstract: An injection needle assembly includes a needle tube, a needle hub holding the needle tube, a protector, a biasing member, a sliding groove, and a sliding protrusion. The protector is movable between a first position at which the needle tip of the needle tube is covered and a second position at which the needle tip of the needle tube is exposed. The sliding groove is located at one of the needle hub or the protector.

Abstract: A portable vein viewer apparatus may be battery powered and hand-held to reveal patient vasculature information to aid in venipuncture processes. The apparatus comprises a first laser diode emitting infrared light, and a second laser diode emitting only visible wavelengths, wherein vasculature absorbs a portion of the infrared light causing reflection of a contrasted infrared image. A pair of silicon PIN photodiodes, responsive to the contrasted infrared image, causes transmission of a corresponding signal. The signal is processed through circuitry to amplify, sum, and filter the outputted signals, and with the use of an image processing algorithm, the contrasted image is projected onto the patient's skin surface using the second laser diode. Revealed information may comprise vein location, depth, diameter, and degree of certainty of vein locations. Projection of vein images may be a positive or a negative image. Venipuncture needles may be coated to provide visibility in projected images.

Abstract: A needle assembly, comprising hub, a needle fixedly connected to said hub, an outer cover for removably receiving said hub and said needle, said outer cover covering a first end of said needle and an inner shield adapted to be connected to said hub for covering a second end of said hub.

Abstract: The aerosol-generating article include a plurality of elements coaxially aligned and assembled within a wrapper, the article having an outlet end and a distal end upstream from the outlet end. The article includes a liquid aerosol-forming substrate, and a liquid retention medium for retaining the liquid aerosol-forming substrate. The wrapper is formed from a sheet of liquid-impervious material, the liquid retention medium being in a first element of the plurality of elements.

Abstract: A method and apparatus is provided for spraying a solution, such as a cleaning solution a barrier material, out of a spray canister device to a surface area of a human body. The spray canister device generally includes a removable sleeved cover element covering an inner canister element. The spray canister device with the removable sleeved cover is easy to carry and easy to spray, and can be handled manually or functions together with other devices.

Abstract: The invention relates to a handset (1) for delivering a pharmaceutical substance, with a housing (2) that exhibits a mouthpiece (8), wherein the mouthpiece (8) can be sealed with a cap (9), and the cap (9) is attached to the housing (2) by means of a spring (16), and can be swiveled around a swivel axis (x) to release the mouthpiece (8). In order to further improve a handset of the kind in question, in particular as relates to attaching the cap to the handset, it is proposed that the spring (16) have an angled progression in a top view, in which the swivel axis (x) is imaged as a line.

Abstract: A handheld nebulizer includes a body having a control assembly and an actuation assembly. The control assembly is in electrical communication with the actuation assembly for delivering nebulized particles of a compound to a subject. A nebulizing chamber accommodates a removable cartridge for conducting nebulization. The removable cartridge holds a mixture of a compound to be nebulized into nebulized particles. A nebulizing element is affixed or detachably mounted to the removable cartridge, and the removable cartridge is in electrical communication with the control assembly. A removable cartridge for a handheld nebulizer is also provided.

Abstract: The present invention refers to a single piece spacer chamber, a base end and a tip end, the base end having a diameter larger than a diameter of the tip end, single piece chamber is made entirely of a flexible material. A medication container is connected to the tip end. The chamber has a truncated cone shape, a plurality of external zigzag popoid folds circumferentially formed through the external side of the chamber, and a plurality of internal folds circumferentially formed through the internal side of the chamber. The popoid folds have a size that decreases from the base end to the tip end. In a collapsed position each popoid folds against an adjacent popoid and fits entirely inside the adjacent popoid.

Abstract: An improved medicant delivery system is disclosed wherein the carrier for the medicant is a fluid that can be atomized or vaporized by exposure to heat. The system provides for repeatable dose of medicant, can be stored in any orientation, and/or has an ability to maximize energy efficiency.

Abstract: A gas washout vent for a patient interface may be configured to allow a flow of patient exhaled gas to an exterior of the patient interface to minimise rebreathing of exhaled gas by the patient and the vent may include: a plurality of vent passages extending between a first and a second side of the vent, each vent passage may include: a plurality of first openings extending from the first side towards the second side, said first openings being uniform in size and shape; a plurality of second openings extending from the second side towards the first side, said second openings being uniform in size and shape; and wherein the first openings and the second openings partially overlap each other at an interface to form constricted passages therebetween.

Abstract: The system, method and computer-readable storage medium are for detection of ventilator and patient disconnections using patient lung compliance estimated on both inhalation and exhalation phases of a breath. A ventilator breathing system (10) provides breathing gas to a patient, and includes a gas supply (12), a patient tubing circuit (14) coupled to the gas supply, and a gas monitoring system (16, 18) associated with the patient tubing circuit and configured to monitor at least flow and pressure. A control unit (20) is coupled to the monitoring system and configured to determine a patient disconnection from the system by estimating a patient lung compliance ratio based upon determined volumes of gas delivered during the inhalation phase of the breath cycle and exiting during the exhalation phase of the breath cycle, and monitored pressures in the patient tubing circuit during the inhalation and exhalation phases of the breath cycle.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: A speaking valve which is applied to a respiration opening of a tracheostomy tube comprises: a main body portion which has a passage portion communicating with the respiration opening; a balloon which makes a motion between an opened state for opening the passage portion of the main body portion and a closed state for closing the passage portion; a syringe which is provided away from the main body portion and accepts a pushing operation to a plunger by a patient; and a coupling tube which couples the syringe and the balloon with each other and makes the balloon in a shrink state transform to a bloat state by the operation to the syringe, so that the motion from the opened state to the closed state is made.

Abstract: A nasal interface for a device that attached to a user's nose is described. The nasal interface is particularly adaptable for a CPAP device and includes a device body having air passages through the body terminating in a pair of end portions, with each end portion having at least one outlet in a first surface of the end portion and a nasal interface supported on the body, the nasal interface comprising a pair of nose buds having flared fittings at end portions thereof.

Abstract: An enhanced flexibility catheter shaft having an elongate flexible body with a proximal end, a distal end, and at least one lumen extending therethrough.