Patents Issued in January 18, 2018
  • Publication number: 20180016199
    Abstract: Pyrazole derivatives as nitrification inhibitors are described herein.
    Type: Application
    Filed: February 5, 2016
    Publication date: January 18, 2018
    Inventors: Barbara Nave, Joachim Dickhaut, Peter Nesvadba, Mihiret Tekeste Sisay, Alexander Wissemeier, Wolfram Zerulla, Gregor Pasda, Olof Wallquist, Allan F Cunningham
  • Publication number: 20180016200
    Abstract: This invention relates to an improved urea-nitrogen stabilizer composition and methods, systems and apparatti for making thereof. The nitrogen stabilizer composition is incorporated into molten urea to result in a composition that contains less biuret, NMP, nitrogen stabilizer and/or impurities and provides an effective solid fertilizer. These compositions are useful in in odor control.
    Type: Application
    Filed: September 13, 2017
    Publication date: January 18, 2018
    Applicant: Koch Agronomic Services, LLC
    Inventors: KURT D. GABRIELSON, Allen Sutton
  • Publication number: 20180016201
    Abstract: The invention refers to a free-flowing ammonium nitrate (AN) product which comprises a mixture of AN particles and beads or granules of activated alumina, a process for preparing the same and the use of said beads or granules as free-flowing additive for AN particles.
    Type: Application
    Filed: February 9, 2016
    Publication date: January 18, 2018
    Inventors: Unai Elizundia Eriz, Mateusz Marek Hass
  • Publication number: 20180016202
    Abstract: An enhanced pyrotechnic composition including an obscurant, a fuel, an oxidizer, and a nonivamide-cyclic anhydride adduct.
    Type: Application
    Filed: March 28, 2017
    Publication date: January 18, 2018
    Inventor: JOHN L. LOMBARDI
  • Publication number: 20180016203
    Abstract: Disclosed is a process for purifying one or more chemical constituents from plant matter using extraction with a fluid that is not a solvent, for example, with a vegetable oil. The extracted chemical constituents may then optionally be further processed by heating in order to induce desired chemical transformations. The extracted chemical constituents are also processed by concentrating at reduced pressure, for example, by distillation.
    Type: Application
    Filed: August 14, 2017
    Publication date: January 18, 2018
    Inventors: Jeffrey Charles Raber, Sytze Elzinga
  • Publication number: 20180016204
    Abstract: A composition comprising olefin oligomers of one or more olefin monomers, the olefin monomers comprising a branched C10 olefin monomer comprising i) 3-propyl-1-heptene, ii) 4-ethyl-1-octene, iii) 5-methyl-1-nonene, or iv) any combination thereof. A composition comprising substantially hydrogenated olefin oligomers, wherein the olefin oligomers are oligomers of one or more olefin monomers, the olefin monomers comprising a branched C10 olefin monomer comprising i) 3-propyl-1-heptene, ii) 4-ethyl-1-octene, iii) 5-methyl-1-nonene, or iv) any combination thereof. A process comprising a) contacting 1) a catalyst system and 2) a monomer feedstock comprising a branched C10 olefin monomer comprising i) 3-propyl-1-heptene, ii) 4-ethyl-1-octene, iii) 5-methyl-1-nonene, or iv) any combination thereof in a reaction zone; and b) forming olefin oligomers.
    Type: Application
    Filed: July 12, 2016
    Publication date: January 18, 2018
    Inventors: Robert C. COFFIN, Steven M. BISCHOF, Lauren M. KATTCHEE, Kenneth M. LASSEN, Jason L. KREIDER
  • Publication number: 20180016205
    Abstract: An object of the present invention is to provide a method for efficiently producing an ?-olefin low polymer at a high ?-olefin low polymer selectivity and a high ?-olefin low polymer yield with suppressing the deterioration of catalytic activity with time, and the invention relates to a method for producing an ?-olefin low polymer, which comprises performing a low polymerization reaction of an ?-olefin in the presence of a catalyst containing a chlorine atom-containing compound (d) and a reaction solvent, wherein the chlorine atom-containing compound (d) that are at least two compounds having specific chlorine atom elimination rate is supplied in predetermined ratio.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 18, 2018
    Inventor: Hiroki EMOTO
  • Publication number: 20180016206
    Abstract: Disclosed herein is a method of preparing 1-octene at high activity and high selectivity while stably maintaining reaction activity by tetramerizing ethylene using a chromium-based catalyst system comprising a transition metal or a transition metal precursor, a cocatalyst, and a P—C—C—P backbone structure ligand represented by (R1)(R2)P—(R5)CHCH(R6)—P(R3)(R4).
    Type: Application
    Filed: October 4, 2017
    Publication date: January 18, 2018
    Inventors: Taek Kyu HAN, Myung Ahn OK, Sung Seok CHAE, Sang Ook KANG, Jae Ho JUNG
  • Publication number: 20180016207
    Abstract: In a process and system for treatment of feed stocks comprising alkylating agent and metal salts, the metal salts are removed from the feedstock by an efficient combination of separations processes. The processes may take place in one or more stages, each stage taking place in one or more vessels. Such treatment processes may remove 99.9% or more of metal salts from a feedstock, while recovering 99.9% or more of the alkylating agent from the feedstock for use in an alkylation reaction, especially of aromatics such as toluene and benzene. Preferred alkylating agents include methanol and mixtures of carbon monoxide and hydrogen, for methylation of toluene and/or benzene. The methylation proceeds over an aluminosilicate catalyst and preferably yields para-xylene with 75% or greater selectivity.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 18, 2018
    Applicant: ExxonMobil Chemical Patents Inc.
    Inventors: Robert G. Tinger, Indulis J. Eilands, John R. Porter, Larry L. Iaccino
  • Publication number: 20180016208
    Abstract: A method for producing a conjugated diolefin is configured as follows. A monoolefin having four or more carbon atoms is fed from a monoolefin feed nozzle(s) installed at n place(s) (n=1, 2, . . . , n). In addition, at least 50% or more of a total amount of an oxygen-containing gas is fed from an oxygen-containing gas feed nozzle located at a bottom of a fluidized bed reactor. Furthermore, the monoolefin feed nozzles at distances a1, a2, . . . , an from the oxygen-containing gas feed nozzle feed the monoolefin having four or more carbon atoms at ratios of b1, b2, . . . , bn (b1+b2+ . . . +bn=1), respectively, and an arithmetic mean value represented by the following formula and obtained from the above distances and the above ratios is 100 mm or more. arithmetic mean value=a1*b1+a2*b2+ . . .
    Type: Application
    Filed: August 4, 2017
    Publication date: January 18, 2018
    Applicant: Asahi Kasei Chemicals Corporation
    Inventors: Hideo MIDORIKAWA, Mamoru WATANABE
  • Publication number: 20180016209
    Abstract: A method for separating an alkyl aromatic hydrocarbon, the method having a step of adding a first diluent and an extractant having a superacid to a mixture comprising the alkyl aromatic hydrocarbon and one or more isomers thereof to carry out an acid-base extraction to thereby form a complex of the alkyl aromatic hydrocarbon with the superacid, and thereafter separating the complex from the mixture, and a step of adding an eliminating agent having a relative basicity in a range of 0.06 to 10 with respect to the alkyl aromatic hydrocarbon and a second diluent to the complex, and carrying out complex exchange of the alkyl aromatic hydrocarbon for the eliminating agent to thereby separate the alkyl aromatic hydrocarbon from the complex.
    Type: Application
    Filed: September 25, 2017
    Publication date: January 18, 2018
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Junya NISHIUCHI, Shinichi NAGAO, Yoshitaka TANAKA, Mitsuharu KITAMURA, Hiroaki OKA
  • Publication number: 20180016210
    Abstract: A process is provided to remove impurities including water, mercaptans, carbonyl sulfide and hydrogen sulfide from hydrocarbon streams containing from 100 to 900 ppm light olefins. In the process, a compound bed containing multiple layers of molecular sieves is used to remove the specific impurities. In situations when the regeneration gas may contain sulfur compounds, a sulfur guard bed may be used to treat the regeneration gas prior to regenerating the compound adsorbent bed.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Bart J. T. Beuckels, Bruno A. De Jonckheere, Luk G. J. Verhulst, Kris A. P. Eeman, Fedrik K. Vancraeynest
  • Publication number: 20180016211
    Abstract: The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula II, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II, wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Applicant: Syngenta Crop Protection, LLC
    Inventors: Denis GRIBKOV, Bjorn ANTELMANN, Fanny BOIS, Harald WALTER, Alain DE MESMAEKER
  • Publication number: 20180016212
    Abstract: Various compositions, including particularly aerosol compositions, containing fluorinated olefins, including particularly tetra- and penta-fluoropropenes, in a variety of applications are disclosed.
    Type: Application
    Filed: August 11, 2017
    Publication date: January 18, 2018
    Inventors: Rajiv R. Singh, Hang T. Pham, Gary Knopeck
  • Publication number: 20180016213
    Abstract: To provide a method for stably storing tetrafluoropropene filled in a container for e.g. storage or transportation, without occurrence of reaction such as polymerization. A method for storing tetrafluoropropene in a gaseous-liquid state composed of a gas phase and a liquid phase in a closed container, wherein the oxygen concentration (content) in the above gas phase is adjusted to at least 3 vol ppm and less than 3,000 vol ppm at a temperature of 25° C.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Applicant: ASAHI GLASS COMPANY, LIMITED
    Inventors: Masato Fukushima, Masaaki TSUZAKI, Maki SHIGEMATSU
  • Publication number: 20180016214
    Abstract: A process is described for directly converting a high fructose feedstock to a product mixture including one or more lower polyols in which 1,2-propanediol is produced in preference to any other lower polyols, wherein a high fructose feed and a source of hydrogen are supplied to a reaction vessel and reacted in the presence of a copper-containing, supported ruthenium catalyst to provide the product mixture.
    Type: Application
    Filed: February 2, 2016
    Publication date: January 18, 2018
    Inventor: Chi Cheng Ma
  • Publication number: 20180016215
    Abstract: Provided are methods for removing one or more components from a butanol based composition. The methods comprise providing a butanol based composition comprising one or more components, targeting at least one component or a combination thereof for reduction, and processing said butanol based composition such that the at least one targeted component is substantially removed. The butanol based composition can, for example, be bio-produced.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 18, 2018
    Inventors: Cecilia CHENG, Ian David DOBSON, Andrew John HOGBEN, Andrew Richard LUCY, John Glenn SUNLEY, Leslie William BOLTON
  • Publication number: 20180016216
    Abstract: Provided is a decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass in which the hemp extract or hemp biomass is heated to a temperature of 40° C. to 100° C. in the presence of one or more divalent or monovalent reagents.
    Type: Application
    Filed: June 26, 2017
    Publication date: January 18, 2018
    Inventors: Jeremy Leker, John Paul Maye
  • Publication number: 20180016217
    Abstract: Methods for generating glycerol tert-butyl ethers include reacting isobutylene and glycerol in the presence of a catalyst and a co-solvent cum co-reactant to produce a mono-, di-, or tri-glycerol tert-butyl ether, where the isobutylene and glycerol are partially miscible.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 18, 2018
    Applicant: SABIC Global Technologies, B.V.
    Inventors: Sunil Shivajirao Dhumal, Vinod Sankaran Nair, Rekha Mahadevaiah, Umesh Krishna Hasyagar
  • Publication number: 20180016218
    Abstract: Methods and systems or devices for synthesis of dimethyl ether (DME) from carbon dioxide and hydrogen are provided. A high surface area hollow fiber catalytic membrane reactor such as with hollow fibers coated with a water permeable membrane material is used. The reactor also contains a bi-functional methanol synthesis component and dehydration catalyst component such that the two-step reaction takes place on the catalyst surface. Produced water permeates through the membrane, exiting the reactor immediately after it is formed. Unreacted reactants and products flow to the reactor exit.
    Type: Application
    Filed: March 23, 2017
    Publication date: January 18, 2018
    Applicant: GAS TECHNOLOGY INSTITUTE
    Inventors: Naomi KLINGHOFFER, Shiguang LI
  • Publication number: 20180016219
    Abstract: Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.
    Type: Application
    Filed: February 12, 2016
    Publication date: January 18, 2018
    Applicant: Novomer, Inc.
    Inventors: Jay J. FARMER, Peter GALEBACH, Kyle SHERRY, Sadesh H. SOOKRAJ
  • Publication number: 20180016220
    Abstract: This invention provides a method for producing high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, high-purity iron(III) citrate substantially free of beta-iron hydroxide oxide, and medical uses thereof.
    Type: Application
    Filed: March 3, 2017
    Publication date: January 18, 2018
    Applicant: Japan Tobacco Inc.
    Inventors: Koji Ando, Naoki Manta
  • Publication number: 20180016221
    Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 18, 2018
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dmitry TSVELIKHOVSKY, Avi PRIEL
  • Publication number: 20180016222
    Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
    Type: Application
    Filed: June 8, 2017
    Publication date: January 18, 2018
    Inventors: Xiaoming ZHANG, Meenakshi S. VENKATRAMAN, Cyrus K. BECKER
  • Publication number: 20180016223
    Abstract: A fluorine-containing ether monocarboxylic acid aminoalkyl ester represented by the general formula: CnF2n+1O[CF(CF3)CF2O]aCF(CF3)COO(CH2)bNR1R2 (wherein R1 is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group, preferably an alkyl group having 1to 6 carbon atoms or an aryl group; R2 is an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group, preferably an alkyl group having 1to 6 carbon atoms or an aryl group; n is an integer of 1 to 3; a is an integer of 2 to 20, preferably an integer of 4 to 10; and b is an integer of 1 to 12, preferably an integer of 1 to 3). Such a fluorine-containing ether monocarboxylic acid ester having an amino group at the end of the ester group is produced by reacting a perfluoroether carboxylic acid fluoride compound CnF2n+1O[CF(CF3)CF2O]1CF(CF3)COF and a hydroxyalkyl amine compound HO(CH2)bNR1R2 in the presence of an alkali metal fluoride.
    Type: Application
    Filed: February 3, 2015
    Publication date: January 18, 2018
    Inventor: Keisuke KOKIN
  • Publication number: 20180016224
    Abstract: This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine sub structure.
    Type: Application
    Filed: April 27, 2017
    Publication date: January 18, 2018
    Inventors: Hang ZHAO, Stefan G. KOENIG, Charles P. VANDENBOSSCHE, Surendra SINGH, Harold Scott WILKINSON, Roger P. BAKALE
  • Publication number: 20180016225
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 15, 2017
    Publication date: January 18, 2018
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20180016226
    Abstract: Neat 4-azidobutylamine and sails of 4-azidobutylamine and processes for producing the same are described herein. Amines represent a large class of organic compounds containing a basic nitrogen atom having a lone pair of electrons and one or more substituent groups. Many amines are used as precursors and feedstocks in a wide variety of industries such as textiles, agriculture, plastics, and pharmaceuticals. One such amine is 4-azidobutylamine, N3-(CH2)4NH2, an amine of butane that also includes an azide.
    Type: Application
    Filed: February 5, 2016
    Publication date: January 18, 2018
    Inventors: Stephen E. SCHNEIDER, David Eugene PEREIRA
  • Publication number: 20180016227
    Abstract: The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in particular as precursors for medicines for the treatment of diseases, disorders or conditions.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 18, 2018
    Applicant: Trillium Therapeutics Inc.
    Inventors: Abdelmalik Slassi, Peter Dove
  • Publication number: 20180016228
    Abstract: This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Applicant: WYETH LLC
    Inventors: Justin Keith MORAN, Jianxin GU
  • Publication number: 20180016229
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers and/or activity modifiers.
    Type: Application
    Filed: August 14, 2017
    Publication date: January 18, 2018
    Inventor: Michael E. Silver
  • Publication number: 20180016230
    Abstract: The present invention relates to crystalline 1-adamantanamine salts, and polymorphic forms thereof, of prostaglandin analog intermediates of formula 3a, 4a and 6a, useful in the preparation of Tafluprost and Lubiprostone and processes for their preparation. The process includes combining 1-adamantanamine, water, an organic solvent, and a compound of Formula 3 or 6, thereby obtaining a suspension. The process also includes isolating the solid salt of Formula 3a or 6a from the suspension.
    Type: Application
    Filed: December 10, 2015
    Publication date: January 18, 2018
    Inventors: Yajun Zhao, Yonggang Li, Uma Kotipalli, Sammy Chris Duncan, Honghai Lv, Kangying Li
  • Publication number: 20180016231
    Abstract: Provided is a method for preparing a structure directing agent (SDA) for crystalline molecular sieve synthesis comprising the steps of (a) hydrolyzing analkyl sulfate counterion of a quaternary ammonium salt to produce an organic ammonium salt having a hydrogen sulfate counterion; and (b) contacting the organic ammonium salt having the hydrogen sulfate counterion with a source of hydroxide in solution to form an organic ammonium salt having a hydroxide counterion; wherein the organic ammonium salt is a structure directing agent (SDA) for crystalline molecular sieve synthesis.
    Type: Application
    Filed: April 20, 2016
    Publication date: January 18, 2018
    Inventors: Steven COLLIER, Da-Ming GOU, Jeremy WILT
  • Publication number: 20180016232
    Abstract: Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 18, 2018
    Applicant: AM Chemicals LLC
    Inventors: Andrei Pavel GUZAEV, Vladimir V. VVEDENSKIY, Khirud GOGOI
  • Publication number: 20180016233
    Abstract: The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing cyclic compounds capable of absorbing electromagnetic radiation energy and having improved photostability due to the presence and location of one or more fluorine groups in relation to the double bond of the ring.
    Type: Application
    Filed: November 28, 2016
    Publication date: January 18, 2018
    Applicant: Commonwealth Scientific and Industrial Research Or ganisation
    Inventors: John Ryan, Mark York
  • Publication number: 20180016234
    Abstract: The present invention relates to phenylpyridines of formula (I) wherein the variables are defined according to the description, processes and intermediates for preparing the phenylpyridines of the formula (I), compositions comprising them and their use as herbicides, i.e. for controlling harmful plants, and also a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one phenylpyridine of the formula (I) to act on plants, their seed and/or their habitat.
    Type: Application
    Filed: January 19, 2016
    Publication date: January 18, 2018
    Inventors: Matthias WITSCHEL, Tobias SEISER, Manuel JOHANNES, Dario MASSA, Trevor William NEWTON, Richard EVANS, Raphael APONTE
  • Publication number: 20180016235
    Abstract: The invention relates to pyridone amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: August 3, 2017
    Publication date: January 18, 2018
    Inventors: Sara Sabina Hadida-Ruah, Corey Anderson, Vijayalaksmi Arumugam, Iuliana Luci Asgian, Brian Richard Bear, Andreas P. Termin, James Philip Johnson
  • Publication number: 20180016236
    Abstract: Compounds for the preparation of pyridone derivatives are provided. In particular, compounds of formula (IA) are provided, wherein the variable groups are as defined in the specification. The compounds of formula (IA) can be used as intermediates in the preparation of pyridone derivatives useful as mitogen-activated protein kinase kinase (MEK) inhibitors and therapeutic agents for treating cancer.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Inventors: Wangyang TU, Haitang ZHANG, Guoji XU, Jiangtao CHI
  • Publication number: 20180016237
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Application
    Filed: May 15, 2017
    Publication date: January 18, 2018
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Publication number: 20180016238
    Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 18, 2018
    Inventors: Qiang YANG, Beth LORSBACH, Gregory WHITEKER, Gary ROTH, Carl DeAMICIS, Thomas CLARK, Kaitlyn GRAY, Belgin CANTURK, Elisabeth J. KANE, Yu ZHANG, Joseck M. MUHUHI
  • Publication number: 20180016239
    Abstract: The present invention relates to compounds according to Formula (I-1) and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
    Type: Application
    Filed: February 11, 2016
    Publication date: January 18, 2018
    Inventors: Blair T. Lapointe, Peter H. Fuller, Hakan Gunaydin, Kun Liu, Nunzio Sciammetta, Benjamin Wesley Trotter, Hongjun Zhang, Kenneth J. Barr, John K. F. Maclean, Danielle F. Molinari, Vladimir Simov
  • Publication number: 20180016240
    Abstract: The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.
    Type: Application
    Filed: May 3, 2017
    Publication date: January 18, 2018
    Inventor: Congxin Liang
  • Publication number: 20180016241
    Abstract: The present invention relates to a process for preparing a statin precursor, which process comprises a first reaction step, wherein a hydroxy-pyrimidine-carbonitrile is reacted with an organic sulfonyl halide to form the sulfonate-pyrimidine-carbonitrile; a second reaction step, wherein the sulfonate-pyrimidine-carbonitrile is reacted with N-methylmethane sulfonamide to form a pyrimidinyl-sulfonamide; and optionally a third reaction step, wherein the pyrimidinyl-sulfonamide is reacted with a reducing agent. All steps are conducted in toluene as the main solvent.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 18, 2018
    Inventors: Ben De Lange, Karin Henderika Maria Bessembinder, Dennis Heemskerk
  • Publication number: 20180016242
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Application
    Filed: December 11, 2015
    Publication date: January 18, 2018
    Inventors: Alison E. MCGONAGLE, Allan JORDAN, Bohdan WASZKOWYCZ, Colin HUTTON, Ian WADDELL, James R. HITCHIN, Kate Mary SMITH, Niall M. HAMILTON
  • Publication number: 20180016243
    Abstract: The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.
    Type: Application
    Filed: February 12, 2016
    Publication date: January 18, 2018
    Inventors: Andreas MEYERHANS, Miguel-Angel MARTINEZ DE LA SIERRA, Annalaura BRAI, Roberta FAZI, Cristina TINTORI, Maurizio BOTTA, Jose-Este ARAQUE, Javier MARTINEZ
  • Publication number: 20180016244
    Abstract: Described are deuterated modulators of S1P1 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: March 25, 2016
    Publication date: January 18, 2018
    Inventors: Chengzhi Zhang, Justin Chakma
  • Publication number: 20180016245
    Abstract: Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease. Yet further disclosed are methods for treating renal cell carcinoma and melanoma. Still further disclosed are methods for reducing metastasis of malignant cells and/or preventing the proliferation of carcinoma cells via spreading due to vascular leakage.
    Type: Application
    Filed: February 27, 2017
    Publication date: January 18, 2018
    Inventors: Robert Shalwitz, Kevin Gene Peters
  • Publication number: 20180016246
    Abstract: The present invention is directed to process for preparation of ?-form crystal of Mirabegron, (R)-2-(2-aminothiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl) amino) ethyl) phenyl) acetamide of formula (1).
    Type: Application
    Filed: February 2, 2016
    Publication date: January 18, 2018
    Inventors: Girij Pal Singh, Dhananjai Shrivastava, Paramvir Bhadwal, Malhari Deoram Bhor, Suryabhan Prabhakar Dange, Sonaraj Bholenath Jangam
  • Publication number: 20180016247
    Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Jagabandhu Das, Ramesh Padmanabha, Ping Chen, Derek J. Norris, Arthur M.P. Doweyko, Joel C. Barrish, John Wityak
  • Publication number: 20180016248
    Abstract: A method for producing ethylene oxide comprising: a) providing one or more feed components, wherein the one or more feed components contains at least ethylene obtained by dehydrating ethanol; b) contacting the one or more feed components with an ethylene oxide catalyst bed disposed in a reactor tube, the ethylene oxide catalyst bed comprising: (1) an upstream ethylene oxide catalyst having a first cesium concentration and (2) a downstream ethylene oxide catalyst having a second cesium concentration, wherein the first cesium concentration is higher than the second cesium concentration.
    Type: Application
    Filed: July 17, 2017
    Publication date: January 18, 2018
    Applicant: Scientific Design Company, Inc.
    Inventor: Ashok S. Padia