Patents Issued in February 22, 2018
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Publication number: 20180050111Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.Type: ApplicationFiled: June 30, 2017Publication date: February 22, 2018Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
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Publication number: 20180050112Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.Type: ApplicationFiled: February 19, 2016Publication date: February 22, 2018Inventors: Takeshi Onda, Akira Masuda, Ken Yamakawa, Chisato Tomiyama, Yasushi Yoneta, Yuichi Akatsu, Keiichirou Yamamoto, Ayaka Mochizuki
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Publication number: 20180050113Abstract: A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.Type: ApplicationFiled: November 2, 2017Publication date: February 22, 2018Applicant: OPKO Biologics Ltd.Inventors: Udi Eyal Fima, Oren Hershkovitz
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Publication number: 20180050114Abstract: A method of manufacturing a complex for cancer cell chemotherapy comprises an aptamer preparation step of preparing a nucleic acid aptamer having an aptamer base sequence specifically binding to HER2, and a complex formation step of forming an aptamer-anticancer drug complex by reacting the aptamer prepared in the aptamer preparation step with an anticancer drug.Type: ApplicationFiled: January 17, 2017Publication date: February 22, 2018Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATIONInventors: Jae-Hong SEO, CHANG ILL BAN, Hun-Ho JO, Ji-Young Kim, Young-Kwan Cho
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Publication number: 20180050115Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.Type: ApplicationFiled: August 18, 2017Publication date: February 22, 2018Inventors: Chung-Yuan MOU, Nai-Yuan KOU, Si-Han WU, Yi-Ping CHEN
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Publication number: 20180050116Abstract: Pharmaceutical formulations for parenteral administration comprising taxane compounds complexed with cyclodextrins and polyethylene glycol, methods of making the pharmaceutical formulations and methods of treating cancer patients using the pharmaceutical formulations.Type: ApplicationFiled: March 14, 2016Publication date: February 22, 2018Inventors: William W. Zhao, John K. Thottathil, Denise Smith, Xiaodong Sun, Xiangyu Dong
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Publication number: 20180050117Abstract: The present invention relates to a vector which comprises a nucleic acid sequence encoding for the frataxin (FXN) gene for use in the prevention and treatment of neurological phenotype associated with Friedreich ataxia in a subject in need thereof.Type: ApplicationFiled: March 22, 2016Publication date: February 22, 2018Inventors: Hélène PUCCIO, Françoise PIGUET
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Publication number: 20180050118Abstract: Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA target sequence is located in the untranslated or translated region of the nucleic acid encoding the viral protein. Also provided are vector systems, compositions and cells comprising the provided helper nucleic acids and a vector of replicon. Methods of making virus-like replicon particles and populations of virus-like replicon particles (VRP) are also provided.Type: ApplicationFiled: March 15, 2017Publication date: February 22, 2018Inventors: Vernon McNeil COFFIELD, III, Kurt I. KAMRUD, Jonathan F. SMITH
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Publication number: 20180050119Abstract: The objective of the present invention to provide a method for accurately and safely specifying a leakage part of cerebrospinal fluid in a cerebrospinal fluid hypovolemia patient, and a method for effectively treating cerebrospinal fluid hypovolemia with utilizing the specifying method. The method for specifying a leakage part of cerebrospinal fluid in a cerebrospinal fluid hypovolemia patient according to the present invention is characterized in comprising the steps of injecting saline into a bone-marrow space of a spine of the cerebrospinal fluid hypovolemia patient, and detecting the cerebrospinal fluid or the injected saline leaked from a dura mater of the spine to specify the leakage part of the cerebrospinal fluid.Type: ApplicationFiled: August 19, 2016Publication date: February 22, 2018Applicant: NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITYInventor: Eiichi NAKAI
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Publication number: 20180050120Abstract: A method of forming metal nanoparticles includes applying a substance to an area of interest, applying cold plasma to the area of interest, and synthesizing nanoparticles from the substance using the cold plasma in the area of interest, wherein the substance is a solution that contains metal ions, and the nanoparticles synthesized are metallic in nature.Type: ApplicationFiled: June 1, 2017Publication date: February 22, 2018Inventor: Emilia M. Kulaga
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Publication number: 20180050121Abstract: An apparatus for sterilizing a dialyzer for extracorporeal blood treatment includes a pulsed electric field generator arranged for generating a pulsed electric field penetrating the dialyzer received between a first electrode and a second electrode, when a pulsed electric voltage is applied between the first electrode and the second electrode of the generator. A method of sterilizing a dialyzer for extracorporeal blood treatment adapted to be executed using the apparatus incorporates, in a process for preparing or manufacturing the dialyzer, at least the steps of generating a pulsed electric field using a predetermined number of electric pulses of defined electric voltage, defined pulse duration and defined pulse-off time between the pulses, and applying the pulsed electric field to the dialyzer.Type: ApplicationFiled: August 21, 2017Publication date: February 22, 2018Inventors: Christian Starke, Sina Burkert
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Publication number: 20180050122Abstract: A system and method of sanitizing one or more structures within an enclosed space includes operatively coupling an ozone ventilation control unit to an ultraviolet (UV) light assembly, an ozone sensor, and an exhaust fan, using the ozone ventilation control unit to operate the UV light assembly to emit UV light into or onto structure(s) of the enclosed space during a cleaning cycle, receiving, by the ozone ventilation control unit, an ozone presence signal indicative of an amount of ozone within the enclosed space from an ozone sensor that detects the amount of ozone within the enclosed space, using the ozone ventilation control unit to selectively activate and deactivate the exhaust fan based on the amount of ozone within the enclosed space, and using the ozone ventilation control unit to selectively activate and deactivate the UV light assembly based on the amount of ozone within the enclosed space.Type: ApplicationFiled: August 19, 2016Publication date: February 22, 2018Applicant: THE BOEING COMPANYInventors: Chao-Hsin Lin, Sharon L. Norris
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Publication number: 20180050123Abstract: An apparatus (100 and/or 200) and corresponding method (500) for air sterilization and disinfection can include an electronics and control module (110 and/or 210), a means for drawing air from the surrounding environment into the apparatus (120 and/or 220), an air management chamber (130 and/or 230), and a housing (170 and/or 270). The means for drawing air from the surrounding environment into the apparatus (120 and/or 220) mobilizes latent pathogens in the environment and draws them into the apparatus (100 and/or 200) for sterilization and disinfection. The air management chamber (130 and/or 230) provides for exposure of the airborne pathogens to UV radiation, via UV LEDs (150 and/or 250), with a dosage sufficient to penetrate the cell walls and destroy the pathogens. The electronics and control module (110 and/or 210) powers the apparatus (100 and/or 200) and interfaces with the electronic components. The housing (170) forms the outer shell of the apparatus (100).Type: ApplicationFiled: October 30, 2014Publication date: February 22, 2018Inventor: Mark D. Krosney
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Publication number: 20180050124Abstract: The present invention relates to an air refining and purifying sterilization module and an air refining and purifying sterilizer including the same, and more particularly, to an air refining and purifying sterilization module and an air refining and purifying sterilizer including the same with excellent sterilization, purification, deodorization, and ventilation performance with respect to various pollutants generated in smoking rooms including tobacco smoke and carbon monoxide and every living spaces as improved catalyst performance. The present invention provides an air purifying sterilizer module in which the photocatalyst unit is formed of an alloy coated metal foam carried with a photocatalytic material and an air purifying sterilizer including the same in the air purifying sterilizer module including a filter unit, a photocatalyst unit, and an ultraviolet lamp.Type: ApplicationFiled: November 27, 2015Publication date: February 22, 2018Applicant: PURESYS CO., LTD.Inventor: Woo-Young LEE
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Publication number: 20180050125Abstract: A method for the reduction and/or removal of pathogenic agents and microorganisms contained in solids, comprising the steps of purification of the starting material to dispose of materials that combine a great size and extreme hardness and malleability; and the adjustment of the humidity degree of the material obtained in step of purification, and the grinding and heating of the material obtained in the step of adjuisting the humidity, where the grinding and heating are carried out simultaneously by subjecting the material to a high pressure while at the same time its temperature is increased by means of an increase in the pressure on the material and the friction caused between the material and the grinding means.Type: ApplicationFiled: April 6, 2017Publication date: February 22, 2018Inventor: ANDRES ADALBERTO ANER
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Publication number: 20180050126Abstract: A lotion composition is provided. The lotion composition includes a) about 1% to about 90%, by weight, of a rheology structurant; and a b) carrier.Type: ApplicationFiled: October 17, 2017Publication date: February 22, 2018Inventors: Robert Ya-lin Pan, Debora Christine Ebert, Peter Christopher Ellingson, Raphael Warren
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Publication number: 20180050127Abstract: The present disclosure is directed to blood dotting compositions comprising platelet microparticles, method of using said compositions, and methods of preparing the same.Type: ApplicationFiled: March 4, 2016Publication date: February 22, 2018Inventor: Majed A. REFAAI
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Publication number: 20180050128Abstract: Delivery articles for wound and surgical site treatment to prevent adhesion, provide antimicrobial benefits, and provide tissue scaffolding or support. The articles include (1) a dispensing unit or similar apparatus, the dispensing unit being selected from a pressurized or pressurizable apparatus. The dispensing unit contains (2) (a) a PGS resin, optionally including micronized PGS thermoset resin (b) a solvent (c) optionally, a propellant or other dispersant, (d) optionally, a mixture or suspension or dispersion or solution of one or more biologic tissue engineering ECM-compatible biologic components, antimicrobials, drugs, growth enhancers, stimulants, trophic agents, tissues, tissue matrices, and cells, and (e) optionally, one or a combination of structural matrix materials, fibers and fillers, gelatin and collagen.Type: ApplicationFiled: August 18, 2017Publication date: February 22, 2018Inventors: Peter D. GABRIELE, Michael S. FLEMMENS, Jeremy J. HARRIS, Jeffrey H. ROBERTSON, Kayla WROBLESKY
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Publication number: 20180050129Abstract: Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.Type: ApplicationFiled: April 5, 2017Publication date: February 22, 2018Inventors: Syed H. Askari, George Horng
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Publication number: 20180050130Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.Type: ApplicationFiled: February 14, 2017Publication date: February 22, 2018Inventors: Xuesong Jiang, Sashank Reddy, Gerald Brandacher, Hai-Quan Mao, Justin Sacks, Xiaowei Li, Kevin Feng, Russell Martin, George C. Yalanis, Ji Suk Choi
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Publication number: 20180050131Abstract: Implantable medicine delivery systems, devices, and associated methods are disclosed herein. In one embodiment, a method of enhancing bone regeneration in a human or animal body includes implanting a three-dimensional scaffold in the human or animal body. The three-dimensional scaffold is constructed from a porous ceramic material, a ceramic-polymer composite of a biodegradable ceramic material and a polymer, or a ceramic-polymer-metal composite of a biodegradable ceramic material, a polymer, and a metal and embedded with curcumin in the porous ceramic material, the curcumin at least partially coating an exterior surface of the porous ceramic material. The method also includes directly and controllably releasing the embedded curcumin into a circulatory system of the human or animal body according to a release profile, thereby achieving enhanced bone regeneration in the human or animal body.Type: ApplicationFiled: July 28, 2017Publication date: February 22, 2018Inventors: Susmita Bose, Amit Bandyopadhyay, Dishary Banerjee, Naboneeta Sarkar
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Publication number: 20180050132Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: ApplicationFiled: October 26, 2017Publication date: February 22, 2018Applicant: ATRIUM MEDICAL CORPORATIONInventors: Keith M. FAUCHER, Hui TANG, Paul MARTAKOS, Theodore KARWOSKI, Allison SULLIVAN, Greg MELVILLE, Scott E. CORBEIL
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Publication number: 20180050133Abstract: Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.Type: ApplicationFiled: March 31, 2017Publication date: February 22, 2018Applicant: Massachusetts Institute of TechnologyInventors: J. David Smith, Rajeev Dhiman, Adam T. Paxson, Christopher J. Love, Brian R. Solomon, Kripa K. Varanasi
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Publication number: 20180050134Abstract: A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.Type: ApplicationFiled: April 20, 2017Publication date: February 22, 2018Inventor: Edward J. Kaplan
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Publication number: 20180050135Abstract: A system (1) for collecting liquid, including a main collecting chamber (10), a main duct section (11, 12, 13) connected to the main collecting chamber (10) in a fluid-communicating manner, and an auxiliary collecting chamber (20, 30, 40). The system (1) has an auxiliary duct section (21, 38, 39) connected to the auxiliary collecting chamber (20, 30, 40) in a fluid-communicating manner for connection to the main duct section (11, 12, 13). The main duct section (11, 12, 13) and the auxiliary duct section (21, 38, 39) form a duct (35, 36, 37) when the main duct section is connected to the auxiliary duct section. A water-soluble closing component (14, 15, 16) closes the duct (35, 36, 37). A hygienic collecting device for liquid, which has a short evacuation time and a flexible collection volume, is provided with the system (1).Type: ApplicationFiled: August 17, 2017Publication date: February 22, 2018Inventor: Thomas REINBOTH
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Publication number: 20180050136Abstract: The invention relates to a chest drainage system (100) for creating and maintaining a sub-atmospheric pressure within the pleural cavity and/or the mediastinum of a patient (P). The system has a chest drainage unit (CDU, 10) with an internal cavity (C) having a first chamber part (C1, 11) and a second chamber part (C2, 12) with an air outlet from the CDU, and a liquid seal chamber (LSC, 13). The second chamber part (C2, 12) of the chest drainage unit is connected to a carbon dioxide sensor (CO2S, 15) for detecting carbon dioxide in any air passing through the liquid seal chamber (LSC, 13), the carbon dioxide sensor being capable of detecting carbon dioxide by a visible color change from a chemical reaction occurring in the carbon dioxide sensor between carbon dioxide and a detector reactant (DC) positioned in the carbon dioxide sensor.Type: ApplicationFiled: March 22, 2016Publication date: February 22, 2018Applicant: Region SyddanmarkInventor: Jens Eckardt
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Publication number: 20180050137Abstract: A wound treatment method capable of promoting the treatment of a wound is provided. The wound treatment method comprising: placing a foam dressing at a wound site; sealing the wound site by attaching a film dressing to the skin adjacent to the wound site; lowering pressure in a sealed space, which is formed between the film dressing and the wound site, to a target negative pressure level by supplying negative pressure generated by a negative pressure generation unit to the sealed space; maintaining the pressure in the sealed space at the target negative pressure level for a first setting period; stopping the supply of the negative pressure for a second setting period, which follows the first setting period; and injecting a medication into the wound site within the second setting period.Type: ApplicationFiled: January 19, 2016Publication date: February 22, 2018Inventors: Hyun Seung RYU, Joon Pio Hong, Jun Hyuk Seo, Hee Jun Park, Soon Gee Hong, Kang Jin Jeon, Hoon Kim
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Publication number: 20180050138Abstract: Systems, methods, and devices for milk expression are provided. In one aspect, a system includes an expression apparatus having an interface configured to engage a breast and an actuation assembly operably coupled to the interface. Actuation of the actuation assembly causes the interface to apply vacuum pressure against the breast to express milk from the breast. The system also includes various sensors for quantifying characteristics of the expressed milk, and a unique identifier allows inventory management of the expressed milk.Type: ApplicationFiled: March 6, 2017Publication date: February 22, 2018Inventors: Jeffery B. Alvarez, Janica B. Alvarez, Nathaniel Gaskin, Polina Segalova
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Publication number: 20180050139Abstract: A blood pump (1) comprises a pump casing (2) having a blood flow inlet (5) and a blood flow outlet (6) connected by a passage (7), and an impeller (3) arranged in said pump casing (2) so as to be rotatable about an axis of rotation (9). The impeller (2) is provided with blades (4) sized and shaped for conveying blood along the passage (7) from the blood flow inlet (5) to the blood flow outlet (6), the impeller (3) being rotatably supported in the pump casing (2) by at least one bearing (10, 20). A surface of the impeller (3) faces a surface of the pump casing (2) spaced from said surface of the impeller (3) by a clearance (31), the clearance (31) being in fluid connection with the passage (7) at a clearance transition point (36). In order to wash out the clearance, at least one wash out channel (30) extends through the impeller (3) and is in fluid connection with the passage (7) via a first opening (34) and with the clearance (31) via a second opening (35).Type: ApplicationFiled: March 16, 2016Publication date: February 22, 2018Inventors: Thorsten Siess, Walid Aboul-Hosn
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Publication number: 20180050140Abstract: A blood pump (1) comprises a pump casing (2) having a blood flow inlet (5) and a blood flow outlet (6) connected by a passage (7), and an impeller (3) arranged in said pump casing (2) so as to be rotatable about an axis of rotation (9). The impeller (3) is provided with blades (4) sized and shaped for conveying blood along the passage (7) from the blood flow inlet (5) to the blood flow outlet (6), the impeller (3) being rotatably supported in the pump casing (2) by at least one contact-type bearing (20) comprising a bearing surface of the impeller (3) facing a bearing surface of the pump casing (2). At least one wash out channel (30) extends through the impeller (3) and is in fluid connection with the passage (7) via a first opening (34) and with the bearing (20) via a second opening (35).Type: ApplicationFiled: March 16, 2016Publication date: February 22, 2018Inventors: Thorsten Siess, Walid Aboul-Hosn
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Publication number: 20180050141Abstract: Blood pump assemblies and methods of manufacturing and operating blood pump assemblies are provided. The blood pump assembly includes a pump and an impeller blade rotatably coupled to the pump. The blood pump assembly also includes a pump housing component sized for passage through a body lumen and coupled to the pump. The pump housing component includes a peripheral wall extending about a rotation axis of the impeller blade. The peripheral wall includes an inner peripheral wall surface and an outer peripheral wall surface. The peripheral wall also includes one or more blood exhaust apertures. Each blood exhaust aperture in the one or more blood exhaust apertures is defined by an inner aperture edge and an outer aperture edge. Each inner aperture edge is chamfered between the inner peripheral wall surface and the outer peripheral wall surface.Type: ApplicationFiled: October 16, 2017Publication date: February 22, 2018Inventors: Scott C. Corbett, Zhongwei Qi, Kar Lee
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Publication number: 20180050142Abstract: A blood pump (1) comprises a pump casing (2) having a blood flow inlet (5) and a blood flow outlet (6) connected by a passage (7), and an impeller (3) arranged in said pump casing (2) so as to be rotatable about an axis of rotation (9). The impeller (3) is provided with blades (4) sized and shaped for conveying blood along the passage (7) from the blood flow inlet (5) to the blood flow outlet (6), and is rotatably supported in the pump casing (2) by a first bearing (10) at a first axial end of the impeller (3) and a second bearing (20) axially spaced apart from the first bearing (10).Type: ApplicationFiled: March 16, 2016Publication date: February 22, 2018Inventors: Thorsten Siess, Walid Aboul-Hosn
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Publication number: 20180050143Abstract: At least some embodiments of the disclosure may advantageously limit bleeding and the occurrence of blood leaks after heart pump implantation. In some embodiments, a base may be provided that includes a flexible layer mechanically coupled with a conduit. The flexible layer may be coupled with the proximal end of the conduit. The conduit may be configured to receive a cannula of the heart pump therethrough. The outer surface of the conduit may be configured to engage a surface of the heart formed after coring the heart. The conduit may be metal and may have a flared and/or beveled distal end. The conduit may be a flexible material. A distal flexible layer may be provided at a distal end of the conduit that is configured to engage with an inner surface of the heart.Type: ApplicationFiled: August 21, 2017Publication date: February 22, 2018Inventors: John Duc Nguyen, Huy Ngo, Carine Hoarau, Fabian Franco
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Publication number: 20180050144Abstract: A method for determining the dry weight of a patient after dialysis therapy, wherein the patient's blood volume is monitored and blood volume values are output. The blood volume values are recorded and evaluated for a predetermined period of time after reaching an ultrafiltration volume appropriately predetermined for the patient, wherein the dry weight of the patient then is determined on the basis of the rate of change of the blood volume during the predetermined period of time.Type: ApplicationFiled: August 17, 2017Publication date: February 22, 2018Inventors: RICHARD ATALLAH, FLORIAN BAUER
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Publication number: 20180050145Abstract: An apparatus for extracorporeal blood treatment includes a body and a monitor unit fixed in the tilt direction which includes a display unit. The apparatus for extracorporeal blood treatment may be configured as a dialysis machine including a housing for accommodating operational components for the extracorporeal blood treatment. The monitor unit includes a display content representation influencing device.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Inventors: OLIVER SCHÄFER, Christian Schleicher
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Publication number: 20180050146Abstract: A blood gas analysis method (100) is provided for determining the partial pressure of oxygen of arterial blood exiting an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to an oxygenation gas and releases excess oxygenation gas as exhaust gas. The method (100) comprises a step (140) of determining an estimate of the partial pressure of oxygen in the exhaust gas, a step (150) of determining the blood oxygen uptake in the oxygenator, and a step (160) of determining the partial pressure of oxygen in the arterial blood by adjusting the estimate using the blood oxygen uptake value. Used in a clinical setting, the method (100) allows a more accurate output of the partial pressure of oxygen in the arterial blood to be provided, which facilitates oxygenator operation.Type: ApplicationFiled: March 3, 2016Publication date: February 22, 2018Inventor: Stephen Turner
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Publication number: 20180050147Abstract: A hemodialysis device which includes a main tube, a first linking tube, a second linking tube and a third linking tube is disclosed. The main tube includes a central tube, an annular tube, a plurality of dialysis holes, a first end and a second end. The central tube includes a blood passage. The annular tube includes a waste passage which surrounds the central tube. The plurality of dialysis holes are located on the central tube, wherein the blood passage is connected to the waste passage via the plurality of dialysis holes. The first end and the second end are the two opposite ends of the main tube. The first linking tube is connected to the first end and to the central tube. The second linking tube is connected to the second end and to the central tube.Type: ApplicationFiled: March 2, 2017Publication date: February 22, 2018Inventor: Hsien-Chang SHIH
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METHODS FOR DELIVERING REGIONAL CITRATE ANTICOAGULATION (RCA) DURING EXTRACORPOREAL BLOOD TREATMENTS
Publication number: 20180050148Abstract: Disclosed are methods, compositions, and devices for improved delivery of regional citrate anticoagulation during extracorporeal blood treatments. Methods comprise quantification of the clearance of calcium and/or citrate using one or more on-line/in-line sensors, establishing a correlation between the differential conductivity between afferent and efferent dialysate and the clearance of calcium and/or citrate. The methods described herein further include quantifying citrate clearance using glucose as a surrogate.Type: ApplicationFiled: April 20, 2016Publication date: February 22, 2018Inventor: Rodney S. Kenley -
Publication number: 20180050149Abstract: An IV pole attachment apparatus includes an attachment portion, a first appendage, a second appendage, a receiving portion, protrusions, and an appendage connection portion. The IV pole attachment apparatus is constructed of silicone or another form of elastomeric substance. One end of IV pole attachment apparatus is a ring-shaped attachment portion. The attachment portion is seamlessly molded to the appendage connection portion. Appendage connection portion is seamlessly connected to the first appendage and the second appendage. The first appendage contains three spaced protrusions molded in a linear consecutive arrangement into the appendage. The first appendage is pulled through the receiving portion. The greater diameter of the protrusions keeps them from easily passing back thorough the aperture of the receiving portion and allows for a buckling action that secures the IV pole attachment apparatus to an IV pole.Type: ApplicationFiled: August 18, 2016Publication date: February 22, 2018Inventors: Lauren McNeill, Christopher Lienhop
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Publication number: 20180050150Abstract: A device for securing tubing or wiring to an article of clothing can be formed from plastic by injection molding. The device includes a primary body portion formed with a shaped opening therein. The shaped opening has an enlarged circular part and an integral linear part. The device also includes a closure button formed with a narrow neck attached to a support member, which in turn is connected to the primary body portion by a tether. The button is sized to fit through the circular opening so that the neck can slide into the linear part and trap an article of clothing between the closure member and the primary body portion. The primary body portion is also formed with a pair of clips that are appropriately sized to receive tubing, such as IV tubing, that can be supported on the patient's clothing and facilitate mobility for the patient.Type: ApplicationFiled: August 19, 2016Publication date: February 22, 2018Inventor: Ruth Carey-Hench
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Publication number: 20180050151Abstract: A needle guard assembly having a resilient arm extending from a base situated to slide along the shaft of a needle. In one implementation the needle guard has an elongate containment member that rides with the resilient arm and is co-operable with the resilient arm to effectuate a covering of the entire distal tip of the needle upon the needle being retracted into the needle guard.Type: ApplicationFiled: November 3, 2017Publication date: February 22, 2018Inventor: Thomas C. KURACINA
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Publication number: 20180050152Abstract: An automatic sensing and warning device for placing an intravenous drip includes a transmitter unit, a blocking unit, a receiver unit, and a fixing device. The transmitter unit is attachable to an injection site on a patient's hand and is operable to transmit an identification signal. The receiver unit is arranged on the blocking unit and includes a drive circuit and a warning device. The fixing device supports the blocking unit and the receiver unit on the intravenous drip pole. The RF receiver is set at a predetermined vertical distance from a drip chamber and areas above and below the RF receiver are respectively defined as dangerous and safe areas. When the injection site is spaced from the drip chamber by a distance shorter than the predetermined distance, the RF receiver receives the identification signal from the RF transmitter and the drive circuit activates the warning device to issue warnings.Type: ApplicationFiled: August 11, 2017Publication date: February 22, 2018Inventors: Ming-Chuan Kuo, Zu-Chun Lin, Chia-Hui Chu, Ping-I Li, Chia-Liang Lu
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Publication number: 20180050153Abstract: An administration set for an infusion pump includes a free-flow prevention device having a movable plunger that includes a cam surface defining an uneven profile along a direction of movement of the plunger, wherein the shape of the cam surface profile indicates the administration set is authorized for use with the infusion pump and may further indicate the specific type of administration set. A sensor in the infusion pump senses movement of the plunger as a platen of the infusion pump is latched and generates a profile signal in the time domain representative of the cam surface profile. A processor evaluates the profile signal and controls operation of the pump to protect a patient from improper loading of an administration set, use of an unauthorized administration set, and/or use of an invalid type of administration set for a chosen infusion protocol.Type: ApplicationFiled: August 22, 2016Publication date: February 22, 2018Inventors: Azur AZAPAGIC, Mohan Jonathan BARKLEY
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Publication number: 20180050154Abstract: Embodiments include methods and systems for maintaining glucose homeostasis. Systems can include a pump, a first reservoir including a homeostasis agent, an umbilical catheter capable of being advanced in the umbilical vein or in the falciform ligament, and a sensor. Systems can also include a biocompatible coating, a microprocessor in communication with the pump and the sensor, and a power supply. Methods can include implanting a pump and reservoir subcutaneously in a patient, advancing a catheter in the umbilical vein or in the falciform ligament, measuring a blood glucose level, pumping a homeostasis agent, and administering the homeostasis agent to the portal venous system.Type: ApplicationFiled: August 17, 2016Publication date: February 22, 2018Inventor: Amos Cahan
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Publication number: 20180050155Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing and at least two separate component parts, wherein for example at least one of these component parts performs a movement relative to the housing during dose setting and for example at least one of these component parts performs a movement relative to the housing during dose dispensing, and wherein the relative movement of the at least two separate component parts with respect to each other during dose setting differs from the relative movement of the at least two separate component parts with respect to each other during dose dispensing.Type: ApplicationFiled: March 11, 2016Publication date: February 22, 2018Inventors: Richard James Vincent Avery, Matthew Meredith Jones, William Marsh, Anthony Paul Morris, David Aubrey Plumptre, Samuel Keir Steel, Robert Frederick Veasey
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Publication number: 20180050156Abstract: An injector includes a trigger mechanism including: a trigger member disposed about an axis having an aperture and a protrusion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a trigger engagement member configured to engage the aperture of the trigger member when the trigger member is in a pre-firing condition; an energy source associated with the ram for powering the ram to expel the medicament; and a user-operable firing-initiation member having an aperture engaged with the protrusion of the trigger member and operable for causing an axial translation of the trigger member in a proximal direction from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.Type: ApplicationFiled: October 13, 2017Publication date: February 22, 2018Applicant: Antares Pharma, Inc.Inventor: Michael Travanty
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Publication number: 20180050157Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.Type: ApplicationFiled: April 3, 2017Publication date: February 22, 2018Inventors: Richard WHALLEY, James WHITE
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Publication number: 20180050158Abstract: A prefilled syringe includes a syringe body filled with a medical fluid, which has a nozzle at a front side, the nozzle being closed with a cap, and which is closed at a rear side with a displaceable plunger; and a plunger rod that can be inserted into the syringe body via the rear side. The plunger rod has a connecting portion at a front side, via which the plunger rod can be connected to the plunger. At least three annular elements, which extend at least in some sections about a longitudinal axis of the rod, are arranged on a rear side of the connecting portion on the plunger rod in such a manner that they are located in the syringe body when the plunger rod is fully connected to the plunger. The three annular elements support a coaxial connection of the rod to the plunger positioned in the syringe.Type: ApplicationFiled: March 2, 2016Publication date: February 22, 2018Inventors: Wolfgang Baldauf, Jörg Heinrich, Christoph Zauner
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Publication number: 20180050159Abstract: A medicament delivery device is presented having a housing, a medicament container holder, arranged movable in relation to the housing and capable of accommodating a medicament container. An activator is arranged in the housing and capable of, upon activation, acting on a medicament container for expelling a dose of medicament, where the activator has a plunger rod, a manually operable dose setting nut rotatably connected to the housing and arranged with first threads. Second threads are arranged on the medicament container holder being arranged to cooperate with said dose setting nut, wherein operation of the dose setting nut will cause the medicament container holder with the medicament container to move towards the plunger rod for setting a dose of medicament to be delivered.Type: ApplicationFiled: February 2, 2016Publication date: February 22, 2018Inventors: Kasper Enge, Gunnar Elmén, Anders Holmqvist
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Publication number: 20180050160Abstract: The disclosure refers to an injection device for automatic spring driven injection of a liquid drug by which doses of an individual size can be set by a user. The injection device comprises a housing defining an interior space and having a longitudinal window, a rotatable dose dial axially retained in relation to the housing, a rotatable scale drum carrying indicia for indicating the size of the set dose, wherein the scale drum is functionally coupled to the dose dial to rotate when the dose dial is rotated to set a dose, a sliding element provided with a sliding window, which sliding element is adapted to slide axially in relation to the housing during dose setting, and through which sliding window the indicia carried by the scale drum is visible. The longitudinal window and the sliding window in combination with the indicia form a dose size display. The scale drum rotates within the interior space defined by the housing during dose setting.Type: ApplicationFiled: October 9, 2015Publication date: February 22, 2018Inventors: Simon Lewis Bilton, Matthew Meredith Jones, William Marsh, Anthony Paul Morris