Patents Issued in March 1, 2018
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Publication number: 20180057598Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.Type: ApplicationFiled: August 4, 2017Publication date: March 1, 2018Applicant: Genentech, Inc.Inventors: Greg LAZAR, Yanli YANG, Erin H. CHRISTENSEN, Julie HANG, Jeong KIM, Seth HARRIS
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Publication number: 20180057599Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.Type: ApplicationFiled: October 23, 2017Publication date: March 1, 2018Applicant: La Trobe UniversityInventors: Nicholas Johannes Hoogenraad, Amelia Jane Johnston, John Silke
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Publication number: 20180057600Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.Type: ApplicationFiled: November 8, 2017Publication date: March 1, 2018Applicants: Pfizer Inc., Bristol-Myers Squibb CompanyInventors: Jing MIN, Yanli Wu, Rory F. Finn, Barrett R. Thiele, Wei Liao, Ronald P. Gladue, Arvind Rajpal, Timothy J. Paradis, Peter Brams, Brigitte Devaux, Yi Wu, Kristopher Toy, Heidi N. Leblanc, Haichun Huang
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Publication number: 20180057601Abstract: The present disclosure relates to a novel humanized antibody capable of binding to ADAM17 and also the amino and nucleic acid sequences coding for said antibody. From one aspect, the disclosure relates to a novel humanized antibody, or antigen-binding fragments, capable of binding to ADAM17 with anti-tumour activities. The disclosure also comprises the use of said humanized antibody as a drug for the treatment of cancer. Finally, the invention comprises compositions comprising said humanized antibody, alone or in combination or conjugation with other anticancer compounds, and the use of same for the treatment of cancer.Type: ApplicationFiled: January 4, 2016Publication date: March 1, 2018Inventors: Peter LOWE, Sven BERGER, Michael TESAR
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Publication number: 20180057602Abstract: The present application relates to compositions of chimeric anti-endoglin antibodies and anti-VEGF agents. Another aspect relates to the use of chimeric anti-endoglin antibodies and Bevacizumab. Another aspect relates to the use of the compositions to inhibit VEGF induced sprouting. Another aspect relates to the use of the compositions to inhibit angiogenesis.Type: ApplicationFiled: November 1, 2017Publication date: March 1, 2018Inventors: Charles P. Theuer, Ben K. Seon
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Publication number: 20180057603Abstract: The present invention provides a fusion proteins comprising (a) a first stretch of consecutive amino acids, the sequence of which is the sequence of an anti-p185her2/neu polypeptide or an anti-EGFR polypeptide; (b) a second stretch of consecutive amino acids, the sequence of which is the sequence of a polypeptide capable of binding at least one polypeptide other than p185her2/neu or EGFR; and (c) a third stretch of consecutive amino acids, the sequence of which comprises the sequence of a biologically active portion of interferon-gamma (IFN?), wherein (b) is located at the carboxy-terminal end of (a), and (c) is located at the carboxy-terminal end of (b). The present invention provides methods and compositions treating or preventing cancer and for sensitizing cancer cells to radiation or a chemotherapeutic agent, which comprises administering i) an anti-p185her2/neu antibody, an anti-EGFR antibody or an erbB kinase inhibitor and interferon-gamma (IFN?); or ii) a fusion protein of the invention.Type: ApplicationFiled: February 9, 2016Publication date: March 1, 2018Applicant: The Trustees of the University of PennsylvaniaInventors: Mark Greene, Hongtao Zhang, Hiromichi Tsuchiya, Yasuhiro Nagai, Lian Lam, Aaron Runkle, Jeffrey Drebin, Mei Qing Ji
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Publication number: 20180057604Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.Type: ApplicationFiled: November 18, 2015Publication date: March 1, 2018Applicants: Genentech, Inc., Adimab LLCInventors: Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan WU, Eric Krauland, Michael Feldhaus, Yin Zhang, Joy Yu Zuchero, Jessica Couch, Mark S Dennis, James A Ernst, Gregory A Lazar
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Publication number: 20180057605Abstract: The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries.Type: ApplicationFiled: December 18, 2015Publication date: March 1, 2018Inventors: Carl Innes WEBSTER, Albert George THOM, Lutz U JERMUTUS, Jonathan P HATCHER
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Publication number: 20180057606Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.Type: ApplicationFiled: July 27, 2017Publication date: March 1, 2018Inventors: Lloyd J. Old, Terrance Grant Johns, Con Panousis, Andrew M. Scott, Christoph Renner, Gerd Ritter, Achim Jungbluth, Elisabeth Stockert, Vincent Peter Collins, Webster K. Cavenee, Huei-Jen Su Huang, Antony Wilks Burgess, Edouard Collins Nice, Anne Murray, George Mark
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Publication number: 20180057607Abstract: It is intended to provide a method for efficiently and stably producing a heteromultimer by incubating homo variants of plural types of heavy chain constant region-containing polypeptides differing in antigen-binding activity under a reducing condition that reorganize the inter-polypeptide disulfide bond between cysteine residues outside of core hinge regions. A feature of the production method of the present invention is that amino acid residues in the core hinge regions do not form any disulfide bond.Type: ApplicationFiled: March 31, 2016Publication date: March 1, 2018Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tomoyuki Igawa, Hitoshi Katada, Yuji Hori, Shojiro Kadono
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Publication number: 20180057608Abstract: The present invention relates to a method of treating a disease. The method comprises administering to a patient in need thereof a recombinant bispecific antibody molecule consisting of a Fab fragment comprising a first binding site for a first antigen, a single chain Fv fragment comprising a second binding site for a second antigen and an immunoglobulin IgG1 CH2 domain.Type: ApplicationFiled: June 27, 2017Publication date: March 1, 2018Inventors: Gundram Jung, Michael DURBEN, Ludger Grosse-Hovest
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Publication number: 20180057609Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof.Type: ApplicationFiled: August 30, 2017Publication date: March 1, 2018Inventors: Carl H. June, Yangbing Zhao, Xiaojun Liu
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Publication number: 20180057610Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.Type: ApplicationFiled: November 3, 2017Publication date: March 1, 2018Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
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Publication number: 20180057611Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).Type: ApplicationFiled: November 13, 2017Publication date: March 1, 2018Inventors: Nicolas FISCHER, Giovanni MAGISTRELLI, Francois ROUSSEAU, Krzysztof MASTERNAK, Pauline MALINGE
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Publication number: 20180057612Abstract: Provided is a method for producing HPMCAS capable of reducing the average particle size of HPMCAS particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose acetate succinate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension, a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate, and a drying step of drying the liquid-removed hypromellose acetate succinate.Type: ApplicationFiled: August 22, 2017Publication date: March 1, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Mitsuhiro YOSHIDA, Junichi MATSUBARA, Kazuki KIKUCHI
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Publication number: 20180057613Abstract: Provided is a method for producing HPMCP capable of reducing the average particle size of HPMCP particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose phthalate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension, a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate, and a drying step of drying the liquid-removed hypromellose phthalate.Type: ApplicationFiled: August 22, 2017Publication date: March 1, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Mitsuhiro YOSHIDA, Junichi MATSUBARA
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Publication number: 20180057614Abstract: Depolymerisation of alginic acid by microwave treatment.Type: ApplicationFiled: May 9, 2017Publication date: March 1, 2018Inventors: Markus KLINGER, Toqeer AHMED, Anne Grete JUUL, Dorthe STENBAEK
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Publication number: 20180057615Abstract: A rubber compound containing silicon dioxide for the production of tyres and comprising a polymer base with a cross-linkable unsaturated chain, a filler comprising silicon dioxide, a silane bonding agent and a vulcanization system. The filler further comprises a composite mineral consisting of a mineral of the zeolite family, onto which a layer of silicon dioxide has been deposited.Type: ApplicationFiled: March 11, 2016Publication date: March 1, 2018Applicant: BRIDGESTONE CORPORATIONInventors: Francesco BOTTI, Raffaele DI RONZA
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Publication number: 20180057616Abstract: Copolymers of styrene and vinylpyridine having residual monomer levels of less than about 1000 parts per billion and processes for preparing said copolymers.Type: ApplicationFiled: August 29, 2017Publication date: March 1, 2018Inventors: Xiaojun Wang, Graciela B. Arhancet, Richard Vonder Embse, John Hume
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Publication number: 20180057617Abstract: A polymer having N-functional imide groups is prepared from reactants that include: (a) an ethylenically unsaturated anhydride or diacid monomer; (b) at least one co-monomer that is different from (a) having an ethylenically unsaturated group that is reactive with (a); and at least one compound reactive with the anhydride or diacid functional groups of (a) that is represented by Chemical Formula I: H2N—R1. With respect to Chemical Formula I, R1 is selected from NH2 or OH. Pigment dispersions and coating compositions are also prepared with the polymers having N-functional imide groups.Type: ApplicationFiled: August 29, 2016Publication date: March 1, 2018Inventors: Jonathan Paul Breon, Hongying Zhou, Brian Thomas Dillon, Simion Coca
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Publication number: 20180057618Abstract: An ethylene alpha-olefin copolymer having (a) a density of from about 0.910 g/cc to about 0.940 g/cc; (b) a weight average molecular weight of from about 150,000 g/mol to about 300,000 g/mol; and (c) a melt index at a load of 2.16 kg of from about 0.01 dg/10 min. to about 0.5 dg/min.; wherein a 1 mil blown film formed from the polymer composition is characterized by (i) a Dart Impact strength greater than about 175 g/mil; (ii) an Elmendorf machine direction tear strength greater than about 20 g/mil; and (iii) an Elmendorf transverse direction tear strength greater than about 475 g/mil.Type: ApplicationFiled: November 7, 2017Publication date: March 1, 2018Inventors: Ashish M. SUKHADIA, Guylaine ST. JEAN, Qing YANG, Max P. MCDANIEL
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Publication number: 20180057619Abstract: Disclosed are systems and methods for the production of polyacrylic acid and superabsorbent polymers from ethylene oxidation to form ethylene oxide. Reacting the ethylene oxide with carbon monoxide to form to beta propiolactone (BPL) or polypropiolactone (PPL), or a combination thereof. An outlet configured to provide a carbonylation stream comprising the BPL or PPL, or a combination thereof and using one or more reactors to convert BPL to acrylic acid or to convert at least some of the BPL to PPL, and then to convert PPL to acrylic acid. An outlet configured to provide a PPL stream to a second reactor tm to convert at least some of the PPL to AA or a third reactor to convert at least some of the PPL to AA. The outlet configured to provide an AA stream to a fourth reactor to convert the AA to polyacrylic acid.Type: ApplicationFiled: February 12, 2016Publication date: March 1, 2018Applicant: Novomer, Inc.Inventor: Sadesh H. SOOKRAJ
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Publication number: 20180057620Abstract: A solid catalyst component for the polymerization of olefins made from or containing Mg, Ti, halogen and an electron donor of formula (I) or (II) When activated with an aluminum alkyl and optionally an external electron donor, solid catalyst component can give high activity and stereospecificity in the polymerization of olefins.Type: ApplicationFiled: March 7, 2016Publication date: March 1, 2018Applicant: Basell Poliolefine Italia S.r.l.Inventors: Alessandro MIGNOGNA, Giampiero MORINI, Reynald CHEVALIER
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Publication number: 20180057621Abstract: A solid catalyst component for the polymerization of olefins made from or containing Mg, Ti, halogen and an electron donor of formula (I) or (II): When activated with an aluminum alkyl and optionally an external electron donor, the solid catalyst component can give high activity and stereospecificity in the polymerization of olefins.Type: ApplicationFiled: March 7, 2016Publication date: March 1, 2018Applicant: Basell Poliolefine Italia S.r.l.Inventors: Alessandro MIGNOGNA, Giampiero MORINI
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Publication number: 20180057622Abstract: The present disclosure relates to a catalyst component for the polymerization of olefins comprising Mg. Ti and an electron donor such as mercaptoester derivatives of the general formula (I). in which Z is selected from C, Si, O, N, S or P, with the proviso that the atoms O, S, P and N are not directly linked to either the carboxylic group or the sulfur atom of formula (I), the R2 groups, equal to or different from each other, are selected from hydrogen or a C1-C20 hydrocarbon radicals, optionally containing a heteroatom selected from halogen, P, S, N, O and Si, which can be fused together to form one or more cycles, m is a number satisfying the valences of Z and n is an integer ranging from 1 to 10, X is O or S, Y is —OR3, —NR4R5) or R6 groups in which R1 and R3 are selected from C1-C15 hydrocarbon groups, optionally containing a heteroatom selected from halogen, P, S, N, O, and Si, R4-R5 groups, independently, are hydrogen or R1 groups, and R6 groups have the same composition as R1 groups.Type: ApplicationFiled: March 31, 2016Publication date: March 1, 2018Applicant: BASELL POLIOLEFINE ITALIA S.R.L.Inventors: ALESSANDRO MIGNOGNA, IGOR KASHULIN, GIAMPIERO MORINI, ILYA NIFANT'EV
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Publication number: 20180057623Abstract: Processes of forming polyolefins are described herein. One or more specific embodiments of the processes generally include introducing olefin monomer selected from C2-C3 olefins into a first reaction zone under first polymerization conditions to form a first polyolefin; withdrawing a transfer effluent from the first reaction zone, the transfer effluent including first polyolefin and unreacted olefin monomer; introducing the transfer effluent, a comonomer selected from C4-C8 olefins, and additional olefin monomer to a second reaction zone under second polymerization conditions to form a second reactor product; maintaining an essentially constant comonomer:olefin monomer ratio in the second reaction zone; and withdrawing at least a portion of the second reactor product, wherein the second reactor product includes a bimodal polyolefin.Type: ApplicationFiled: November 6, 2017Publication date: March 1, 2018Applicant: Chevron Phillips Chemical Company LPInventors: Scott E. Kufeld, Joel A. Mutchler
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Publication number: 20180057624Abstract: A low molecular weight copolymer is provided comprising propylene and ethylene, wherein the low molecular weight copolymer has a softening point in the range of 90 to 140° C., wherein the low molecular weight copolymer has a needle penetration that is equal to y, wherein y is defined by the following formula: y??0.000000262249x6+0.000172031278x5?0.046669720165x4+6.701746779438x3?537.286013331959x2+22,802.983472587x?400,204.018086126 wherein x in the above formula is the softening point of the low molecular weight copolymer, and wherein the low molecular weight copolymer has a molecular weight polydispersity index of about 3 to about 25, a crystallinity of about 18% to about 30% measured by X-Ray diffraction, and a Brookfield viscosity in the range of about 1000 to about 4000 cp at 190° C. measured by ASTM D 3236. Adhesive compositions comprising the low molecular weight copolymer are also provided.Type: ApplicationFiled: August 23, 2017Publication date: March 1, 2018Applicant: Eastman Chemical CompanyInventors: Mutombo Joseph Muvundamina, Gary Robert Robe, Timothy Williams, Andrea Gail Hagood, Dhiraj Sudesh Sood, Marc Stacey Somers, Bennett H. Novak, Puthenkovilakom Rajesh Raja, Raymond Prescott Cottle
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Publication number: 20180057625Abstract: A copolymer having tetrafluoroethylene units and units independently represented by formula (I) in a range from 0.02 to 2 mole percent, based on the total amount of the copolymer. Rf is a linear or branched perfluoroalkyl group having from 1 to 8 carbon atoms and optionally interrupted by one or more —0— groups, n is independently from 1 to 6, and z is 0, 1, or 2. The copolymer has a melt flow index in a range from 20 grams per 10 minutes to 40 grams per 10 minutes. The copolymer can be extruded to make articles, such as insulated cables. A method of making the copolymer is also disclosed.Type: ApplicationFiled: February 12, 2016Publication date: March 1, 2018Inventors: Klaus Hintzer, Harald Kaspar, Kai H. Lochhaas, Jens Schrooten, Tilman C. Zipplies, Denis Duchesne
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Publication number: 20180057626Abstract: Provided is a novel copolymer that can express an excellent calcium ion-trapping ability. The copolymer of the present invention includes: 0.1 mol % to 99 mol % of a structural unit (A) derived from a monoethylenically unsaturated monocarboxylic acid (salt) monomer (a); 0.1 mol % to 99 mol % of a structural unit (B) derived from a monomer (b) serving as a monoethylenically unsaturated dicarboxylic acid (salt) or an anhydride thereof; and 0.1 mol % to 50 mol % of a structural unit (C) derived from an ether bond-containing hydrophobic monomer (c).Type: ApplicationFiled: March 4, 2016Publication date: March 1, 2018Inventors: Shigeru Yamaguchi, Rika Matsumoto
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Publication number: 20180057627Abstract: A polymer includes 2-carboxyethyl (meth)acrylate and alkyl (meth)acrylate as constituent units and having an acid value of 7 mg KOH/g to 100 mg KOH/g.Type: ApplicationFiled: May 1, 2017Publication date: March 1, 2018Applicant: FUJI XEROX CO., LTD.Inventor: Takahiro ISHIZUKA
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Publication number: 20180057628Abstract: A nitrile rubber composition comprising a carboxyl group-containing highly saturated nitrile rubber containing ?,?-ethylenically unsaturated nitrile monomer units in a ratio of 5 to 60 wt % and having an iodine value of 120 or less, carbon black, and a polyamine-based cross-linking agent, wherein a content of the carbon black is 100 parts by weight or more and less than 200 parts by weight with respect to 100 parts by weight of the carboxyl group-containing highly saturated nitrile rubber. Accordingly a nitrile rubber composition able to give a cross-linked rubber with excellent in original state physical properties, compression set resistance, and sour gasoline resistance and small in tension set is provided.Type: ApplicationFiled: March 11, 2016Publication date: March 1, 2018Applicant: ZEON CORPORATIONInventors: Shiho MOSAKI, Sayaka INOUE
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Publication number: 20180057629Abstract: The invention relates to a copolymer and a substrate having a surface, at least one part of which is coated with an epilame agent comprising at least one compound in the form of a copolymer comprising V units, N units, optionally at least one M unit, and optionally at least one P unit, linked by covalent bonds by their main chains, wherein wherein W, X, Y, Z are spacer arms, T is a tracer group arranged to determine the concentration of epilame agent in an epilame-coating bath, L is a halogenated, preferably fluorinated, C1-C20 carbon moiety, A is a substrate anchoring moiety, Q is H, CH3, or a hydrocarbon chain different from T. The invention also concerns a method for coating such a substrate with epilame, said method comprising a step of checking the concentration of epilame agent in the epilame-coating bath by means of the tracer group and if necessary, a step of readjusting the concentration of epilame agent in the epilame-coating bath.Type: ApplicationFiled: August 9, 2017Publication date: March 1, 2018Applicant: The Swatch Group Research and Development LtdInventors: Christophe Letondor, Claire Rannoux
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Publication number: 20180057630Abstract: A polyurethane filter foam is provided herein. The polyurethane filter foam may have improved permeability by having both a small cell and a large cell in a range for maximizing the opening property of the foam. In some instance, this is achieved by specifically configuring and foaming a composition of polyether polyol and methylene diphenyl diisocyanate (MDI) to manufacture the polyurethane foam. The polyurethane foam of the present invention can be manufactured without performing a reticulation process.Type: ApplicationFiled: December 27, 2016Publication date: March 1, 2018Applicant: Hyundai Motor CompanyInventors: Byung Guk LIM, Sang Do PARK, Dong Woo JEONG, Seok Nam KANG, Hoon Bok LEE, Kug Hun HAN, Sang Ho KIM, Kwon Yong CHOI, Soon Joon JUNG, Sung Hoon LEE, Mu Young KIM, Kyung Sam KIM, Yoo Kon CHO, Sung Il LEE
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Publication number: 20180057631Abstract: An article of manufacture includes a zinc sulfide layer and a coupling agent adhered to the zinc sulfide layer by a disulfide bond. The coupling agent comprises a functional group extending from the zinc sulfide layer.Type: ApplicationFiled: October 27, 2017Publication date: March 1, 2018Inventors: Thomas M. Deppert, David R. Smith, William C. Mollberg, Brian J. Zelinski
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CONDUCTIVE COMPOSITION FOR FORMING SOLAR CELL COLLECTOR ELECTRODE, SOLAR CELL, AND SOLAR CELL MODULE
Publication number: 20180057632Abstract: An object of the present invention is to provide: a conductive composition for forming a solar cell collector electrode that can form a collector electrode with favorable adhesion with regard to a transparent conductive layer; a solar cell having a collector electrode formed using the composition; and a solar cell module. A conductive composition for forming a solar cell collector electrode, includes: a metal powder (A); an epoxy resin (B); a cationic curing agent (C); and a blocked carboxylic acid (D); wherein the blocked carboxylic acid (D) is a compound obtained by reacting a compound (d1) selected from carboxylic acids and carboxylic acid anhydrides with a vinyl ether compound (d2).Type: ApplicationFiled: June 25, 2015Publication date: March 1, 2018Inventors: Nao SATO, Kazunori ISHIKAWA -
Publication number: 20180057633Abstract: A downhole tool for controlling the flow of a fluid in a wellbore comprises: an annular body having a flow passage therethrough; a frustoconical element disposed about the annular body; a sealing element carried on the annular body and configured to engage a portion of the frustoconical element; and a bottom sub disposed about the annular body; wherein at least one of the frustoconical element and the bottom sub comprise a polymeric composite that includes: a polymer component comprising one or more of the following: a poly(ether ether ketone); or an epoxy, and a filler crosslinked with the polymer component.Type: ApplicationFiled: August 31, 2016Publication date: March 1, 2018Applicant: Baker Hughes IncorporatedInventors: Rostyslav Dolog, Juan Carlos Flores, Darryl Ventura, Valery N. Khabashesku
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Publication number: 20180057634Abstract: Various embodiments disclosed relate to a method of forming a polypeptide. The method includes contacting a first amino acid-derived N-thiocarboxyanhydrosulfide monomer as a crystalline solid with a polymerization initiator (e.g., in an alkane suspension) to give a polypeptide product. The method further includes contacting the polypeptide product with a second amino acid-derived N-thiocarboxyanhydrosulfide monomer in an alkane suspension.Type: ApplicationFiled: August 25, 2017Publication date: March 1, 2018Inventors: Donghui Zhang, Jinbao Cao, Brandon Chan, David Siefker
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Publication number: 20180057635Abstract: Disclosed is a production method comprising a step of obtaining a poly(arylene sulfonium salt) comprising a terminal group including at least one functional group selected from the group consisting of a carboxy group, a hydroxy group and an amino group, and a step of dealkylating or dearylating the poly(arylene sulfonium salt) to obtain a polyarylene sulfide resin, and a polyarylene sulfide resin comprising a terminal group including a functional group obtainable by the production method.Type: ApplicationFiled: February 23, 2016Publication date: March 1, 2018Applicants: DIC Corporation, National University Corporation, Iwate UniversityInventors: Shun ARAKI, Hajime WATANABE, Satoshi OGAWA, Toshikazu TAKATA
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Publication number: 20180057636Abstract: An aromatic polysulfone produced by polymerizing a dihalogeno compound represented by general formula (A) shown below, and a dihydric phenol represented by general formula (B) shown below, the aromatic polysulfone having a value (Mw/Mn) for the ratio between the weight average molecular weight (Mw) and the number average molecular weight (Mn) of less than 1.8, and having a number average molecular weight (Mn) of at least 6,000 but less than 14,000. (In the formula, each of X and X? independently represents a halogen atom; each of R1, R2, R3 and R4 independently represents an alkyl group having a carbon number of 1 to 4 or an alkoxy group having a carbon number of 1 to 4; each of n1, n2, n3 and n4 independently represents an integer of 0 to 4; and when n1, n2, n3 or n4 is an integer of 2 to 4, the plurality of R1, R2, R3 or R4 groups may be the same as, or different from, each other.) Vertical axis: 5% weight reduction temperature (° C.Type: ApplicationFiled: March 15, 2016Publication date: March 1, 2018Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Shinji OHTOMO, Masanobu MATSUBARA
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Publication number: 20180057637Abstract: A method for producing a cross-linked siloxane network comprises the steps of: (a) providing a first part comprising (i) a first siloxane compound comprising at least one cyclic siloxane moiety, (ii) an inorganic particulate material, and (iii) an aminosilane compound, (b) providing a second part, the second part comprising a hydroxide salt, (c) combining the first part and the second part to produce a reaction mixture, (d) heating the reaction mixture to a temperature sufficient for the hydroxide salt to open the ring of the cyclic siloxane moiety, and (e) maintaining the reaction mixture at an elevated temperature so that at least a portion of the opened cyclic siloxane moieties react to produce a cross-linked siloxane network.Type: ApplicationFiled: July 31, 2017Publication date: March 1, 2018Inventor: Russell A. Stapleton
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Publication number: 20180057638Abstract: The present invention provides a silicone resin substrate, including quartz cloth and a silicone resin composition, wherein the silicone resin composition contains a silicon atom-bonded aryl group in an amount of 10% by mol or more and 99% by mol or less based on the whole silicon atom-bonded organic groups contained in the silicone resin composition. The present invention also provides a metal layer-formed silicone resin substrate, a cured silicone resin substrate, and a metal layer-formed cured-silicone resin substrate, using the silicone resin substrate. Each substrate excels in heat resistance and weather resistance as well as dielectric properties at high frequency.Type: ApplicationFiled: July 18, 2017Publication date: March 1, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Saiko KIMURA, Yoshihira HAMAMOTO
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Publication number: 20180057639Abstract: A pore sealing treatment is performed in order to enhance the heat-shielding property of an anode oxide film by blocking at least the openings of open pores. In the first step of the pore sealing treatment, a solvent-typed pore sealing agent (first pore sealing agent) is used, and a first silicon-based oxide film is formed. In the second step of the pore sealing treatment, a non-solvent-typed pore sealing agent (second pore sealing agent) is used, and a second silicon-based oxide film is formed. In contrast to the first pore sealing agent, the second pore sealing agent is substantially free from the volume contraction in the application step or in the firing step. Consequently, even when the incompletely blocked openings remain after the first step, these incompletely blocked openings can be certainly blocked by the second silicon-based oxide film.Type: ApplicationFiled: July 24, 2017Publication date: March 1, 2018Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventor: Hideo YAMASHITA
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Publication number: 20180057640Abstract: An alkoxysilane functionalized polysiloxane polymer can be prepared from a mixture of reactants including: a) a polysiloxane polymer having two or more reactive functional groups selected from -A-NH2, -A-OH, -A-N?C?O, -A-COOH, or combinations thereof; and b) at least one alkoxysilane having a functional group that is reactive with the reactive functional groups on the polysiloxane polymer. The alkoxysilane functionalized polysiloxane polymer can be combined with additional components to form a coating composition.Type: ApplicationFiled: August 31, 2016Publication date: March 1, 2018Inventors: Renlong Gao, Shanti Swarup, Xiangling Xu
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Publication number: 20180057641Abstract: One of the purposes of the present invention is to provide a polysiloxane macromonomer which has high hydrophilicity and a narrow molecular weight distribution and is usable as a material for ophthalmic lenses.Type: ApplicationFiled: August 29, 2017Publication date: March 1, 2018Applicant: Shin-Etsu Chemical Co., Ltd.Inventor: Shoji ICHINOHE
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Publication number: 20180057642Abstract: This invention relates to a process for producing an isotactic polypropylene based composite, comprising: reactive blending of isotactic polypropylene homo-polymer; polypropylene grafted with a carboxylic anhydride or a furan type moiety such as maleic anhydride grafted polypropylene; and an amino silane such as (3-aminopropyl)triethoxysilane to produce an isotactic polypropylene based composite such that the crystallization temperature of the isotactic polypropylene based composite is in a range of about 120° C. to about 126° C. The reactive blending can further take place in the presence of an organically modified nanoclay.Type: ApplicationFiled: August 25, 2017Publication date: March 1, 2018Inventors: Ray Sinha Suprakas, Jayita Bandyopadhyay, Mary Khoza, Vincent Ojijo, Manfred Rudolf Scriba
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Publication number: 20180057643Abstract: The present invention relates to a masterbatch comprising colorant particles, a polyol poly(hydroxy fatty acid) ester dispersing agent and a carrier resin. The masterbatch is used for coloring thermoplastic polymer compositions. The present invention also relates to a method for producing said masterbatch, a colored thermoplastic polymer composition comprising said masterbatch and colored thermoplastic products formed of said colored thermoplastic composition.Type: ApplicationFiled: March 10, 2016Publication date: March 1, 2018Applicant: EINAR A/SInventor: Viggo Creemers NORN
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Publication number: 20180057644Abstract: This invention relates to a polymeric pipe, and more particularly a polymeric pipe where the pipe comprises a cross-linked polyolefin formed from extruded polyolefin comprising a bismaleimido crosslinker. This invention relates to the manufacturing of plastic pipes and tubing of polyolefinic polymers such as polyethylene, with crosslinking by a bismaleimido crosslinker, to produce crosslinked polyethylene (PEX) pipes and tubing.Type: ApplicationFiled: April 20, 2016Publication date: March 1, 2018Inventor: Patrik Roseen
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Publication number: 20180057645Abstract: A two-component type epoxy resin composition for a fiber reinforced composite material is a two-component type epoxy resin composition for a fiber reinforced composite material that includes the following components [A] to [C], wherein the content of the component [C] is 6 to 25 mass parts relative to 100 mass parts of the component [A]. The fiber reinforced composite material is a fiber reinforced composite material made by combining and curing the two-component type epoxy resin composition for the fiber reinforced composite material and a reinforcing fiber, [A]: an epoxy resin, [B]: an acid anhydride and [C]: a quaternary ammonium salt or a quaternary phosphonium halide or an imidazolium salt.Type: ApplicationFiled: March 25, 2016Publication date: March 1, 2018Inventors: Hideki Oka, Nobuyuki Tomioka, Shiro Honda
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Publication number: 20180057646Abstract: Carbon fiber composite additives, media incorporating the carbon fiber composites, and related methods are provided herein. In some aspects, a composition includes at least one medium; and a carbon fiber composite incorporated with the at least one medium, the carbon fiber composite including one or more carbon fibers with an epoxy resin matrix applied thereto to produce a composition having improved characteristics and filtration performance.Type: ApplicationFiled: June 30, 2017Publication date: March 1, 2018Inventors: Gwen Marie Lanphere Gross, Lori Nelson Blair, Deborah Ann Taege
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Publication number: 20180057647Abstract: A wrapping tape may be formed of a length of elastically deformable material with a length, uniform width along the length, a top side, and a bottom side. A first edge of the tape is parallel to a second edge, thereby defining the uniform width. The tape includes a first depression formed into the top side and alongside the entire first edge. A second depression is also formed into the bottom side and alongside the entire second edge. The first depression on the top side is configured to be received into the second depression on the bottom side when the wrapping tape is wrapped around a cylinder, thereby overlapping the tape upon itself as it is wrapped. The depressions prevent the formation of a protruding bulge as the tape is overlapped.Type: ApplicationFiled: August 30, 2017Publication date: March 1, 2018Inventor: Michael Vincent Nasco