Abstract: The present specification discloses an endoscope having a tip section equipped with multiple viewing elements. Each of the viewing elements' field of view is illuminated by a discrete illuminator, such as a LED, being operated in a flash mode. The flash mode of operation of the LEDs enable doctors to obtain a position of the endoscope tip within a patient's body from outside by viewing the light emitted by the LEDs. Since the light is emitted for short pre-defined periods of time, the heat generated by the LEDs during their periods of operation is within a safe threshold value, and does not cause any burn injury inside the patient's body.

Abstract: Disclosed embodiments integrate a camera into an intraoral mirror. Integrating a camera into an intraoral mirror provides an efficient way to record and display what is visible to the healthcare provider in the mirror.

Abstract: Disclosed is a video laryngoscope having a body, an insertion section extending from the body generally parallel to a median plane of the laryngoscope extending through the body, and a display screen assembly extending from the body generally perpendicular to the median plane, the body comprising a grip portion intermediate the display screen assembly and the insertion section. The display screen assembly, comprising a display screen, extends laterally from the body and the inner edge of the display screen falls within the lateral extent of the body. The grip portion is also of a minimum size to allow an adult to grip the laryngoscope, the hand abutting the screen assembly.

Abstract: Improvements to user interfaces for ophthalmic imaging systems, in particular Optical Coherence Tomography (OCT) systems are described to improve how diagnostic data are displayed, analyzed and presented to the user. The improvements include user customization of display and reports, protocol driven work flow, bookmarking of particular B-scans, accessing information from a reference library, customized normative databases, and ordering of follow-up scans directly from a review screen. A further aspect is the ability to optimize the contrast and quality of displayed B-scans using a single control parameter. Virtual real time z-tracking is described that maintains displayed data in the same depth location regardless of motion.

Abstract: An optical coherence tomography imaging device (1) for imaging a retina of a human subject comprises a base (10) having a planar contact surface (11), an optical unit (30) providing a sample beam to scan the retina of the human subject and a head support (80) to be contacted by a head portion of the human subject, the head support (80) defining an entrance position of the sample beam entering an eye of the human subject. An angle between the sample beam at the entrance position and the planar contact surface (11) of the base (10) is 50 to 90°. This arrangement ensures that the head rests in a stable and well defined position with respect to the OCT optics. The risk of negative effects on the imaging process due to head movements, in particular due to movements during the scan time of the OCT device is considerably reduced. Furthermore, the device may assume a compact form factor.

Abstract: An eye imaging apparatus can include a housing, an optical imaging system in the housing, and a light source in the housing to illuminate an eye. The optical imaging system can include an optical window at a front end of the housing with a concave front surface for receiving the eye as well as an imaging lens disposed rearward the optical window. The apparatus can comprise a light conditioning element configured to receive light from the light source and direct said light to the eye. The apparatus can further include an image sensor in the housing disposed to receive an image of the eye from the optical imaging system. In various embodiments, light conditioning element includes at least one multi-segment surface. In some embodiments, the housing is provided with at least one hermitic seal, for example, with the optical window. In some embodiments, time sequential illumination is employed.

Abstract: An eye imaging apparatus can include a housing, an optical imaging system in the housing, and a light source in the housing to illuminate an eye. The optical imaging system can include an optical window at a front end of the housing with a concave front surface for receiving the eye as well as an imaging lens disposed rearward the optical window. The apparatus can comprise a light conditioning element configured to receive light from the light source and direct said light to the eye. The apparatus can further include an image sensor in the housing disposed to receive an image of the eye from the optical imaging system. In various embodiments, light conditioning element includes at least one multi-segment surface. In some embodiments, the housing is provided with at least one hermitic seal, for example, with the optical window. In some embodiments, time sequential illumination is employed.

Abstract: Techniques for combining physiological and health information are provided. An example method includes receiving one or more physiological parameters of a user from one or more devices in data formats specific to the devices, translating the received physiological parameters from their respective data formats into a common data format, storing the translated physiological parameters into a common data structure configured to store data in the common data format, retrieving the stored physiological parameters for display in a user interface, wherein the user interface displays one or more human-readable physiological characteristics of the user based on the retrieved physiological parameters, and repeating the translating, the storing and the retrieving, upon receipt of one or more other physiological parameters from the devices, to update the displayed human-readable physiological characteristics.

Abstract: A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.

Abstract: Various aspects of the instant disclosure are directed to imaging tissue. As may be implemented in accordance with one or more embodiments, aspects of the present disclosure are directed to apparatuses and methods involving the following. A light source includes an array of light emitters that illuminate a tissue region of a heart wall with light at different wavelength ranges. A light collector collects multispectral images including respective images collected at each of the different wavelength ranges at which the tissue region is illuminated. A catheter positions the light source and light collector proximate the tissue region of the heart wall for respectively illuminating the tissue region and collecting the multispectral images. A display circuit collects and displays one or more images depicting a condition of the health of heart wall tissue, based on the respective images collected at the different ones of the wavelength ranges.

Abstract: A disease diagnosis and skin age measurement apparatus includes: a first light collection unit; a second light collection unit; a spectrometer configured to measure a spectrum of the light which is collected by the second light collection unit; a spectrum data comparison unit for disease diagnosis configured to compare the spectrum measured by the spectrometer and reference spectrum data for disease diagnosis; a CCD; an image data comparison unit configured to compare the digital image converted by the CCD and a reference image; a disease diagnosis unit configured to determine whether there is a disease in the body tissue; and/or a spectrum data comparison unit for skin age measurement configured to measure skin age by comparing a spectrum measured by the spectrometer and reference spectrum data for skin age measurement, wherein the light projected onto the body tissue is collimate light.

Abstract: A system includes a processor; a cellular, WiFi, or Bluetooth transceiver coupled to the processor; an accelerometer or a motion sensor coupled to the processor; and a sensor coupled to the processor to sense mood, wherein text, image, sound, or video is rendered in response to the sensed mood.

Abstract: The present invention relates to a device (22) for processing input signals (34a, 34b) related to a vital sign of a subject (10), comprising an interface (24) for receiving a non-invasively detected input signal (34a, 34b), a feature extraction module (26) for extracting at least one feature of the input signal (34a, 34b), said at least one feature including an instantaneous frequency representation (40a, 40b) of the input signal (34a, 34b) and/or an instantaneous amplitude representation (42a, 42b) of the input signal (34a, 34b), a processing module (28) for determining a signal information content parameter (52) for the input signal (34a, 34b) based on the at least one extracted feature, said signal information content parameter (52) being indicative of information on a vital sign of the subject (10) included in the input signal (34a, 34b) and a combination module (30) for combining a plurality of input signals based on the signal information content parameters (52) of the plurality of input signals into a

Abstract: The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.

Abstract: A system for applying an electrical stimulation includes a lead and a stylet slidably disposed within a lumen of the lead body and extending proximally therefrom. The lead includes a plurality of insulated conductor wires electrically isolated from one another and each having a distal segment terminating at distal end, an intermediate segment, and a proximal segment terminating at a proximal end, wherein the distal ends are electrically coupled to a respective one of the stimulating electrodes and the intermediate segments extend proximal the lead body and are characterized as having a non-coiled configuration.

Abstract: A system for managing care of a person receiving emergency cardiac assistance includes one or more capacitors arranged to deliver a defibrillating shock to a person; one or more electronic ports for receiving a plurality of signals from sensors for obtaining indications of an electrocardiogram (ECG) for the person; and a patient treatment module executable on one or more computer processors using code stored in non-transitory media and to provide a determination of a likelihood of success from delivering a future defibrillating shock to the person with the one or more capacitors, using a mathematical computation applied to a vector value defined by signals from at least two of the plurality of signals.

Abstract: This document provides methods and materials related to the non-invasive measurement of analytes in blood.

Abstract: The invention relates generally to methods of detecting reactive oxygen species (ROS) in cardiac tissue and treatment modalities for ablating ROS-associated tissue in cardiac disease. The methods rely upon targeting ROS-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded atrial EGMs for a tissue to assess ROS content and underlying AF organization as a function of ROS blockade conditions.

Abstract: An electrophysiologic catheter with a distal electrode assembly carrying very closely-spaced bipole microelectrodes on a plurality of divergent spines that can flexibly spread over tissue surface area minimized detection of undesirable noise, including far-field signals. Each spine has a flexible microelectrode panel having a substrate, at least one pair of microelectrodes, a trace for each microelectrode, and a soldering pad. Adjacent microelectrodes of a bipole pair are separated by a space gap distance ranging between about 50-300 microns. Each microelectrode may have a width of about 200 or 300 microns.

Abstract: A data collection unit obtains physiological data from a subject interface on a subject. The subject interface can be connected to the data collection unit. When the subject interface is connected to the data collection unit, subject interface contacts on the subject interface make contact with data collection unit contacts on the data collection unit. Some of the data collection unit contacts are for communicating physiological data from the subject interface to the data collection unit. Some of the contacts are for powering the data collection unit upon the subject interface being connected to the data collection unit and for powering down the data collection unit upon the subject interface being disconnected from the data collection unit.

Abstract: Example devices are disclosed herein that include a first elongated band coupled to a first housing to be located on a first side of a head of a subject and a second housing to be located near a second side of the head of the subject, the first elongated band comprising a first set of electrodes. The example device also includes a second elongated band coupled to the first housing and to the second housing, the second elongated band comprising a second set of electrodes. In addition, the device includes a third elongated band coupled to the first housing and to the second housing, the third elongated band comprising a third set of electrodes.

Abstract: A system and method is disclosed for measuring muscle reflexes (e.g., a bulbocavernosus reflex) as a tool for identifying/diagnosing dysfunctions (e.g., spinal cord abnormalities, bladder voiding dysfunction, and sexual organ dysfunction) non-invasively by using mechanical stimulation. The system and method includes a probe having a predetermined patient contacting portion, wherein when the contacting portion is moved into contact with a particular area of the patient (e.g., the patient's genitals), the contact induces a muscle reflex. The probe detects the pressure resulting from the contacting portion being abruptly and forcibly brought into contact with the particular area. Such detection is used to electronically initiate capture of electrical responses from a plurality of electrodes placed on the patient's skin in proximity to the particular area. Such electrical responses are processed to determine characteristics of the patient's reflexes of one or more muscles adjacent to the electrodes.

Abstract: Concepts presented herein include an apparatus for monitoring EMG signals of a patient's laryngeal muscles. The apparatus includes an endobronchial tube having an exterior surface and two lumens for providing ventilation. Conductive ink electrodes are formed on the exterior surface of the endobronchial tube. The conductive ink electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least one conductor is coupled to the conductive ink electrodes and is configured to carry the EMG signals received by the conductive ink electrodes to a processing apparatus.

Abstract: A system and method for treating Alzheimer's disease by delivery of an agent within the brain. At least one image of a target region is acquired, and at least one magnetic resonance diffusion tensor imaging (MR-DTI) scan of the target region is acquired. A diffusion tensor is calculated from the at least one MR-DTI scan, and at least one of an agent distribution and an agent concentration from the images and the calculated diffusion tensor is calculated. Using at least one of the calculated diffusion tensor, the images, the calculated agent distribution, and the calculated agent concentration, the placement of a delivery instrument is planned to deliver the agent to the target region to achieve a desired agent concentration and/or agent distribution within the target region.

Abstract: Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.

Abstract: The subject matter discloses a noninvasive method and device for detection, measurement and monitoring of Pulmonary Interstitial fluid—Extravascular Lung Water —volumes in inpatient settings: Intensive Care Units, Emergency Rooms, Internal Hospital Departments, and daily monitoring of chronic patient in outpatient settings: outpatient departments, rehab centers and Home monitoring. The disclosed method is based on the analysis of lung tissue thermodynamic properties, and their deviation from normal value. The device measures the rate of temperature change of a lung tissue by measuring the exhaled gas temperature changing rate during cooling/heating of lung tissue. The cooling/heating of lung tissue may be achieved by prompt changing one of the inhaled gas parameters temperature, and/or humidity, and/or rate of breathing, and/or tidal volume, and/or type of gas and etc. The change is performed at the beginning of measurement, and is kept during entire measurement time.

Abstract: A high intensity preparation, physical exercise and recovery system configured to prepare muscles for workout through vibration, accept muscular input of high intensity, recover muscles through vibration. Embodiments provide an exercise system that enables a user to obtain a high intensity workout in a small amount of time, for example 15 minutes, and yet increase the user's metabolic rate for hours. Embodiments of the invention may further perform an initial and/or ongoing analysis in terms of body composition analysis and/or extremity composition analysis/score in order to target particular muscles, fat and/or skeletal areas. In one or more embodiments the system may provide outputs including suggested alterations in physical activity and/or food to consume in order to achieve targeted goals for example as compared to the user's trends of change over time, or in comparison to other user's trends down to the granularity of extremities and not just overall body metrics.

Abstract: This disclosure relates to a hierarchy of classifiers, including linear discriminant analysis (LDA) classifiers, arranged to provide simultaneous control of multiple degrees of freedom of a prosthetic. The high accuracy of the hierarchical approach allows pattern recognition techniques to be extended to permit simultaneous control, potentially allowing amputees to produce more fluid, life-like movements, ultimately increasing their quality of life. The hierarchy may also be used to control a biological interface that allows input to computers for persons with disabilities, used as a potential video-game controller, and used as an input interface for tablets, and phones.

Abstract: A lancing device comprising a lancet holder for holding an exchangeable lancet and comprising a drive element for driving the lancet holder. The drive element has two spring elements comprising a lancing spring element for accelerating the lancet holder in the lancing direction and a restoring spring element for accelerating the lancet holder counter to the lancing direction. The drive element has a carriage unit with a spring-tensioning carriage part and a lancing carriage part, and the spring-tensioning carriage part and the lancing carriage part are arranged to be displaceable in translation relative to one another and form a lancing spring element receiving region and a restoring spring element receiving region. The lancing spring element receiving region can be reduced by translational displacement of the spring-tensioning carriage part relative to the lancing carriage part, in order to pre-tension the lancing spring element within the lancing spring element receiving region.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Abstract: Methods, devices, and systems are provided for correcting lag in measurements of analyte concentration level in interstitial fluid. The invention includes receiving a signal representative of sensor data from an analyte monitoring system related to an analyte level measured over time, computing rates of change of the sensor data for a time period of the sensor data, computing a rate distribution of the rates of change, transforming the rate distribution into a linear arrangement, determining a best-fit line for the transformed rate distribution, computing a slope of the best-fit line; and using the slope of the best-fit line as a representation of a variability of the analyte level to adjust an amount of lag correction applied to the sensor data. Numerous additional features are disclosed.

Abstract: There are provided an endoscope system processor device, an endoscope system, an operation method for an endoscope system processor device, and an operation method for an endoscope system for calculating objective diagnostic information, which is easier to understand than the oxygen saturation, based on the oxygen saturation. The endoscope system processor device includes: a receiving unit that receives an image signal obtained by imaging an observation target with an endoscope; an oxygen saturation calculation unit that calculates an oxygen saturation based on the image signal; a pixel specification unit that specifies an out-of-range pixel in which the oxygen saturation deviates from a specific range set in advance; and a diagnostic information calculation unit that calculates diagnostic information as a numerical value using information of the out-of-range pixel.

Abstract: A near infrared spectrometer and method for wavelength and path length correction are disclosed. The spectrometer includes a number of photodiodes that transmit broadband near infrared measurement light into the tissue and at least one broadband detector which measures the light signal transmitted through the tissue. A processor estimates chromophore concentrations through a comparison of measured light attenuation and modeled light attenuation. The light attenuation model utilizes a light path length distribution derived from a Monte Carlo model and accounts for the spectral shape of the light source as a function of temperature.

Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Abstract: The present invention relates to a biological probe structure, as well as apparatuses, systems, and methods employing this structure. In particular embodiments, the structure includes a hermetically sealed unit configured to receive and transmit one or more optical signals. Furthermore, the structure can be implanted subcutaneously and interrogated externally. In this manner, a minimally invasive method can be employed to detect, treat, and/or assess the biological target. Additional methods and systems are also provided.

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods.

Abstract: A body-mountable device may be formed of a polymeric material. A molding form can define a cavity and polymeric material can be formed using the mold to create a device shaped in accordance with the cavity. Electronics disposed on a substrate can be encapsulated within the polymeric material by forming a first layer of polymeric material, positioning the substrate on the first layer, and then forming a second layer of polymeric material over the substrate. A channel can expose a sensor disposed on the substrate. The channel may be formed while molding the second layer of polymeric material over the substrate. The molding form can include a protrusion that extends toward the sensor. A sacrificial sealant material can be applied to the sensor or the protrusion to create a seal between the protrusion and the sensor. The polymeric material forms around the sealed protrusion to create the channel.

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

Abstract: A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.

Abstract: Provided are sensor systems and methods for detecting analytes of bodily fluids. The systems can be used to reduce the administration volume of certain compounds and/or fluids during medical monitoring or other procedures by providing a calibration path configured to receive a first fluid, a sample path isolated from the calibration path, the sample path configured to receive a bodily fluid from a subject, and a sensor apparatus comprising at least one sensor selectively positionable between the calibration path and the sample path.

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract: The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

Abstract: Technologies are generally described for measuring skin moisture using a skin moisture measuring device. Example devices and systems described herein may include one or more of an elongated enclosure, an inlet, a moisture sensor, and/or a cooling unit. The inlet may be arranged at a first end of the elongated enclosure, and may be configured to be in contact with skin and receive moisture transpiring from the skin. The moisture sensor may be arranged between the first end and a second end inside the elongated enclosure, and configured to detect an amount of the moisture. Further, the cooling unit may be arranged at the second end of the elongated enclosure, and configured to cool and condense the moisture. The cooling unit may be controlled to maintain a substantially constant temperature difference between a first temperature proximate the moisture sensor and a second temperature proximate the cooling unit.

Abstract: The present invention relates to a method of diagnosing, or providing a prognosis to, or for providing the likelihood of developing, malignant melanoma in a subject, the method comprising the steps of: (a) measuring two or more markers in blood perfusion dynamics at and/or around a skin lesion site; and (b) determining if the two or more markers is different to a normal value. The invention also relates to a device for diagnosing/providing a prognosis to/for malignant melanoma in a subject.

Abstract: An apparatus and system diabetes management.

Abstract: An alcohol consumption determination method includes: detecting an effective frame of an input voice signal; detecting a difference signal of an original signal of the effective frame; performing fast Fourier conversion on the original signal and the difference signal; and determining, in the frequency domain, whether alcohol has been consumed based on a slope difference between the fast-Fourier-transformed original signal and the fast-Fourier-transformed difference signal. Accordingly, it is also possible to determine whether a driver or an operator from a remote location has consumed alcohol and a degree of the consumption, thus preventing an accident caused by an individual operating a vehicle under the influence.

Abstract: To improve convenience in a wearable electronic apparatus that measures biological information. An electronic apparatus includes a sensor mechanism, a main body, and a retaining mechanism. The sensor mechanism acquires biological information of a user. The main body supports the sensor mechanism in a movable manner in an upper/lower direction. The retaining mechanism changes the sensor mechanism and the user's body between an unpress state and a press state by moving the sensor mechanism at the main body. With the electronic apparatus, a displacement of the sensor mechanism from the body is prevented and the maintenance of a contact condition is secured, an optical measurement becomes possible; therefore, it is thereby possible to improve convenience for a user without adjusting a position, etc.

Abstract: Breaths of a subject are identified based on the concentration of carbon dioxide at or near the airway of the subject. Troughs corresponding to inhalation are identified and plateaus corresponding to exhalation are identified. A breath is identified responsive to a trough being followed by a plateau.