Abstract: Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.

Abstract: The invention described in the application relates to a panel of gene expression markers for node-negative, ER-positive, HER2-negative breast cancer patients. The invention thus provides methods and compositions, e.g., kits and/or microarrays, for evaluating gene expression levels of the markers and methods of using such gene expression levels to evaluate the likelihood of relapse of a node-negative, ER-positive, HER2-negative breast cancer patient. Such information can be used in determining treatment options for patients.

Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Cyclin Dependent kinase inhibitors (CDKi), methods of determining the sensitivity of a cell to a CDKi, methods of treating a patient with a CDKi and methods of screening for candidate CDKi.

Abstract: This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the disclosure relates to methods for diagnosing prostate cancer, methods of distinguishing between less aggressive and high aggressive prostate cancer, methods of determining predisposition to recurrence of prostate cancer, methods of monitoring progression/regression of prostate cancer, methods of assessing efficacy of compositions for treating prostate cancer, and methods of screening compositions for activity in modulating biomarkers of prostate cancer.

Abstract: The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect methylation of PCDHGA12 gene whose 5?UTR or exon 1 region is specifically methylated in lung cancer cells, and to a method of detecting lung cancer and the stage of its progression using the biomarker. The diagnostic kit according to the present invention makes it possible to diagnose lung cancer at an early stage in an accurate and rapid manner compared to conventional methods and can be used for prognosis and monitoring of lung cancer and the stage of its progression.

Abstract: The present disclosure provides compositions (i.e., amplification primers and probes), methods, and kits that are particularly useful for detecting and/or quantifying nucleic acids present in a sample, such as those derived from HIV or a lentiviral vector.

Abstract: Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used.

Abstract: Methods of accelerating wound healing in diabetic subjects using autologous cell grafts treated to specifically inhibit Protein Kinase C delta (PKC6), as well as cells and compositions for use in these methods. Provided herein are methods for preparing cells for application to a wound in a diabetic subject. The methods include incubating the cells in the presence of an effective amount of a PKC6 inhibitor.

Abstract: Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.

Abstract: A stirrer for a crystallizing evaporator such a crystallizing evaporator for crystallizing sucrose from concentrated beet juice. The stirrer includes at least one active flow-conducting means selected from a group consisting of a plurality of flow-conducting propellers arranged along a shaft of the stirrer and a screw running along the shaft.

Abstract: In some examples, an apparatus includes a pallet supporting a plurality of workpieces, the pallet including through-holes structured to pass a quenching fluid. In some examples, the apparatus further includes a reservoir of quenching fluid configured to provide the quenching fluid, and a plurality of upturned wall portions extending from the pallet and substantially surrounding the exteriors of the plurality of workpieces. The plurality of upturned wall portions may be located in relative orientation to the plurality of workpieces to regulate heat transfer coefficients of the plurality of workpieces during a quenching operation.

Abstract: The present disclosure relates to a method of producing a tube of a duplex stainless steel, in particular a duplex stainless steel suitable for use in fuel injection systems for injection of fuel into the combustion chamber of a combustion engine.

Abstract: A high-strength steel having a specified chemical composition, wherein parameter Peff is 0.050% or more, the relationship (TS0?TS)/TS0?0.050 is satisfied, wherein TS is defined as tensile strength determined at a temperature of 350° C. after aging has been performed under the condition of a Larson-Miller Parameter (LMP) of 15700, and wherein TS0 is defined as tensile strength determined at a temperature of 350° C. before the aging is performed, and having a toughness represented by a vE?20 of 100 J or more in a weld heat-affected zone, which is formed when welding is performed.

Abstract: In the production of a non-oriented electrical stress sheet by hot rolling a slab having a chemical composition comprising, by mass %, C: not more than 0.005, Si: 1.5-6.0, Mn: 0.05-2.0 and P: 0.03-0.15, subjecting to a hot band annealing, if necessary, cold rolling, finish annealing, and forming an insulation coating, the cooling from 700° C. to 500° C. in the finish annealing is conducted in an oxidizing atmosphere with an oxygen potential PH2O/PH2of not less than 0.001 for 1-300 seconds, whereby P is segregated into the surface of the steel sheet after the finish annealing to obtain a non-oriented electrical steel sheet enhancing a crystal grain growth properties in the stress relief annealing.

Abstract: Provided is a grain-oriented electrical steel sheet including a steel sheet having a steel sheet surface in which a groove, which extends in a direction intersecting a rolling direction and of which a groove depth direction matches a sheet thickness direction, is formed. In a case where the groove is seen on a longitudinal groove cross-section including a groove extension direction and the sheet thickness direction, an arithmetic average height Ra of a roughness curve, which constitutes a contour of a groove bottom region of the groove, is 1 ?m to 3 ?m, and an average length RSm of a roughness curve element, which constitutes the contour of the groove bottom region, is 10 ?m to 150 ?m.

Abstract: Ferritic stainless steel sheet which is excellent in ridging resistance which comprises, by mass %, Cr: 10 to 30%, Sn: 0.005 to 1%, C: 0.001 to 0.1%, N: 0.001 to 0.1%, Si: 0.01 to 3.0%, Mn: 0.01 to 3.0%, P: 0.005 to 0.1%, and S: 0.0001 to 0.01% and has a balance of Fe and unavoidable impurities and which has an X-ray diffraction strength in the {100}<012> orientation from a surface layer to t/4 (“t” is sheet thickness) of 2 or more.

Abstract: According to one embodiment, a laser processing device includes a light irradiation section, and a mirror. The light irradiation section is adapted to emit a laser beam from a light source from a tip. The mirror is opposed to the tip of the light irradiation section. The mirror is adapted to reflect the laser beam emitted from the light irradiation section with an aspherical reflecting surface. An angle formed between the laser beam transmitted from the light irradiation section to the mirror and the laser beam reflected by the mirror is equal to or larger than 90 degrees.

Abstract: The proposed invention relates to processes of extraction and concentration of radio nuclides and can be used in radiochemical technologies when processing liquid radioactive wastes. A method for extraction of americium from liquid radioactive wastes and its separation from rare-earth elements comprises simultaneous extraction of americium and rare-earth elements from radioactive nitrate solution with neutral solution of organic extracting agent in polar fluorinated organic solvent, washing of saturated with metals organic phase, selective re-extraction of americium. N,N,N?,N?-tetraalkyl-amide of diglycolic acid is used as an extracting agent and solution containing 5-20 g/L of complexon, 5-60 g/L of nitrogen-containing organic acid and 60-240 g/L of salting-out agent is used as a solution for re-extraction of americium. Technical effect is the extraction of americium from acidic liquid radioactive solutions and its separation from all rare-earth elements in a single extraction cycle.

Abstract: A single-phase alloy is formed, as weight percentages, of N % of gold, M % of tungsten, with N+M=100, M?8 and N?60. Also disclosed is a process for preparing such an alloy use of such an alloy and decorative sheets made from such an alloy.

Abstract: The present invention discloses copper alloy containing cobalt and silicon, which comprises (in percentage of weight): 69% to 92% of copper; 6.5% to 30.5% of zinc; 0.01% to 3% of cobalt; and 0.01% to 0.5% of silicon; wherein the total content of copper and zinc is greater than 95%, and the content of inevitable impurities is less than 0.2%. Preferably, the copper alloy comprises matrix phases of copper-zinc ? solid solution and CoxSiy precipitated phases; the CoxSiy precipitated phases are dispersedly distributed on a matrix phase; the percentage of the matrix phases by area is greater than or equal to 95%; and, the percentage of the CoxSiy precipitated phases by area is 0.01% to 5%.

Abstract: A nickel-based alloy composition consisting, in weight percent, of: between 7.0 and 1.0% chromium, between 4.0 and 14.0% cobalt, between 1.0 and 2.0% rhenium, between 0.5 and 11.0% tungsten, between 0.0 and 0.5% molybdenum, between 4.0 and 6.5% aluminium, between 8.0 and 12.0 tantalum, between 0.0 and up to 0.5% hafnium, between 0.0 and 0.5% niobium, between 0.0 and 0.5% titanium, between 0.0 and 0.5% vanadium, between 0.0 and 0.1% silicon, between 0.0 and 0.1% yttrium, between 0.0 and 0.1% lanthanum, between 0.0 and 0.1% cerium, between 0.0 and 0.003% sulphur, between 0.0 and 0.05% manganese, between 0.0 and 0.05% zirconium, between 0.0 and 0.005% boron, between 0.0 and 0.01% carbon, the balance being nickel and incidental impurities.

Abstract: A modified alloy is disclosed including a base alloy composition and an additive gamma prime antioxidant. The base alloy composition includes a concentration of a gamma prime antioxidant less than an effective concentration of the gamma prime antioxidant. The additive gamma prime antioxidant is intermixed with the base alloy composition to form the modified alloy, preferentially segregating to a gamma prime phase of the modified alloy and increasing the concentration of the gamma prime antioxidant to be at least the effective concentration of the gamma prime antioxidant. The effective concentration imparts reduced oxidation susceptibility of the gamma prime phase. An article is disclosed including the modified alloy. A coated article is disclosed including a coating disposed on a surface of an article having the base alloy composition. The coated article includes a reduced stress accelerated gamma prime oxidation static crack growth susceptibility in comparison with the base alloy composition.

Abstract: A cobalt-based cladding alloy for an engine valve includes, by mass %: Cr: 13% to 35%; Mo: 5% to 30%; Si: 0.1% to 3.0%; C: 0.04% or less; Ni: 15% or less; W: 9% or less; Fe: 30% or less; Mn: 3% or less; S: 0.4% or less; and Co and inevitable impurity elements as a remainder. The amount of Co is 30% or more.

Abstract: A laser cladding or plasma transferred arc overlay welding process may be used advantageously to apply and to control the material properties of a coating designed for protecting the substrate against wear, corrosion and oxidation at elevated temperature. Furthermore, a laser cladding or plasma transferred arc overlay welding process may be used to apply the coating alloy materials in applications where traditional thermal spray or weld-applied coatings are not practical. By using these welding methods very good bonding is achieved by fusion during welding. At the same time the properties of the clad layer is preserved by the limited dilution typical of these two welding methods compared traditional overlay welding, by e.g. Gas Tungsten Arc Welding and the like.

Abstract: To provide a wire rod for bolts that has excellent acid pickling properties and the resistance to delayed fracture after quenching and tempering, and a bolt using the same. Disclosed is a wire rod for bolts that has excellent acid pickling properties and resistance to delayed fracture, including, in percent by mass: C: 0.3 to 0.6%; Si: 1.0 to 3.0%; Mn: 0.1 to 1.5%; P: more than 0% and 0.020% or less; S: more than 0% and 0.020% or less; Cr: 0.3 to 1.5%; Al: 0.02 to 0.10%; and N: 0.001 to 0.020%, with the balance being iron and inevitable impurities, wherein in a d× 1/4 position of the wire rod, where d is a diameter of the wire rod, a ferrite area ratio is in a range of 10 to 40%, with the remaining microstructure being bainite, pearlite and an inevitably formed microstructure, and a C content in a position at a depth of 0.1 mm from a surface layer of the wire rod is in a range of 50 to 100% of a C content in a base material.

Abstract: Disclosed are non-magnetic metal alloy compositions and applications that relate to non-magnetic metal alloys with excellent wear properties for use in dynamic three-body tribological wear environments where an absence of magnetic interference is required. In one aspect, the disclosure can relate to a drilling component for use in directional drilling applications capable of withstanding service abrasion. In a second aspect, a hardbanding for protecting a drilling component for use in directional drilling can be provided. In a third aspect, a method for prolonging service life of a drilling component for use in directional drilling can be provided.

Abstract: Provided are a grain-oriented electrical steel sheet with low iron loss even when including at least one grain boundary segregation element among Sb, Sn, Mo, Cu, and P, and a method for manufacturing the same. In our method, Pr is controlled to satisfy Pr??0.075T+18, where T>10, 5<Pr, T (hr) is the time required after final annealing to reduce the temperature of a secondary recrystallized sheet from 800° C. to 400° C., and Pr (MPa) is the line tension on the secondary recrystallized sheet during flattening annealing. As a result, a grain-oriented electrical steel sheet in which iron loss is low and a dislocation density near crystal grain boundaries of the steel substrate is 1.0×1013 m?2 or less can be obtained even when the grain-oriented electrical steel sheet contains at least one of Sb, Sn, Mo, Cu, and P.

Abstract: The disclosure provides nickel free Zr—Cu—Al metallic glass-forming alloys and metallic glasses comprising at least of Pt, Pd, and Co where the atomic fraction of Zr ranges from 50 to 70, the atomic fraction of Cu ranges from 15 to 45, the atomic fraction of Al ranges from 5 to 15, and the combined atomic fraction of Pt, Pd, and Co ranges from 1 to 10.

Abstract: A blade outer air seal (BOAS) or segment thereof comprises: a metallic substrate having an inner diameter (ID) surface; and a coating system along the inner diameter surface comprises: a bondcoat atop the substrate; and a ceramic barrier coat atop the bondcoat. The bondcoat has a combined content of one or more of molybdenum, chromium, and vanadium of at least 50 percent by weight.

Abstract: A method is provided for coating a cylinder of an internal combustion engine. The cylinder (1) has a cylinder lining surface section (4) with a piston running surface (5) that faces an interior space (3) of the cylinder (1) and along which a piston of the internal combustion engine (2) can be moved. The cylinder (1) also has at least one further surface (13, 14) that adjoins the interior space (3). The further surface (13, 14) may be a bearing section surface (13) for mounting a crankshaft of the internal combustion engine (2), and a run-out section surface (14) between the bearing section (6) and the cylinder lining surface section (4). The method includes forming a defined structure on the further surface (13; 14) and then spraying a coating on the piston running surface (5).

Abstract: A method (100) for pressing at least one article in anarrangement as well as a pressing arrangement (500). The method comprises providing an article inside a load compartment and feeding a pressure medium into the pressure vessel and increasing (140) the pressure in the load compartment; increasing (120) the temperature and maintaining (150) the increased temperature and the increased pressure for selected periods of time (t1, t2); changing (170) the temperature from the first predetermined temperature level to a second predetermined temperature level (T2); feeding (180) a carbon-containing gas into the pressure vessel; maintaining (190) the second predetermined temperature level for a selected period of time (t3); reducing(200) the temperature in the load compartment; and discharging (210) the pressure medium from the pressure vessel and reducing (220) the pressure in the load compartment.

Abstract: There is disclosed an evaporation method, including: evaporating evaporation material and forming evaporation material particles towards one or more transfer substrates by means of an evaporation source, so as to form an intermediate material layer on a surface of the transfer substrate; heating the one or more transfer substrates to evaporate the intermediate material layer located on the transfer substrate towards a target substrate, a temperature of the heated transfer substrate being less than a temperature of the evaporation source. There is further disclosed an evaporation device.

Abstract: A metal mask substrate includes a metal surface to which a resist is to be disposed. A specular reflectance of incident light to the surface is 45.2% or more.

Abstract: A vacuum arc deposition apparatus for forming a ta-C film on a substrate using arc discharge includes a holding unit that holds a target unit, an anode unit into which electrons emitted from the target unit flow, and a power supply that supplies, between the target unit and the anode unit, a current for generating a plasma by arc discharge. The current supplied by the power supply at the time of the arc discharge is generated by superimposing, on a DC current, a pulse current of a pulse frequency not higher than 140 Hz.

Abstract: Wafer boats for the plasma treatment of disc-shaped wafers, in particular semiconductor wafers for semiconductor or photovoltaic applications, and a plasma treatment apparatus for wafers are described. A wafer boat comprises a plurality of first carrier elements which are positioned parallel to one another, wherein each first carrier element has a plurality of carrier slits for receiving the edge of a wafer or wafer pair, and a plurality of second carrier elements which are positioned parallel to one another, which are each electrically conductive and have at least one recess for holding the edge region of at least one wafer or one wafer pair. An alternative wafer boat comprises a plurality of electrically conductive plate shaped carrier elements, which are positioned parallel to one another and which are less than half as high as the wafers to be received, wherein the carrier elements each have on their opposing sides at least three carrier elements for receiving wafers.

Abstract: A Cu—Ga alloy sputtering target of the present invention is made of a Cu—Ga alloy, in which a carbon concentration is 30 ppm by mass or lower. In an observed structure, an area ratio of crystal grains having a grain size of 10 ?m or less is 5% to 50% and an area ratio of crystal grains having a grain size of 100 ?m or more is 1% to 30%.

Abstract: A method is provided for depositing a layer on a substrate inside a vacuum chamber by a magnetron sputtering device comprising at least two magnetron cathodes, each equipped with one target, at least one additional electrode, wherein a separate power supply unit is allocated to each magnetron cathode and wherein, in addition to at least one working gas, at least one reactive gas is introduced into the vacuum chamber. In a first phase, a pulsed negative direct current voltage is conducted from each power supply unit to the corresponding magnetron cathode, wherein the power supply units are operated in the push-pull mode. In a second phase, the pulsed direct current voltages provided by the power supply units are switched between the corresponding magnetron cathode and the additional electrode. An electric voltage is applied to the substrate or an electrode at the back of the substrate.

Abstract: The present invention relates to a raw material for chemical deposition in a formula shown below and including an organoplatinum compound in which an alkenyl amine and an alkyl anion are coordinated to divalent platinum. In the formula, n is 1 or more and 5 or less. Each of substituents R1 to R5 on the alkenyl amine is a hydrogen atom, an alkyl group or the like and has a carbon number of 4 or less. Each of alkyl anions R6 and R7 is an alkyl group having a carbon number of 1 or more and 3 or less. The raw material has high vapor pressure enough to make possible the manufacturing of a platinum thin film at low temperature and also has moderate thermal stability.

Abstract: An apparatus for forming diamond, which contains a reaction chamber, means for providing tetrahedranoidal reactant molecules to the reaction chamber; and means for providing single carbon atoms in the reaction chamber to provide for reaction between the single carbon atoms and tetrahedranoidal reactant molecules.

Abstract: Disclosed is a method of depositing a thin film, which includes supplying a purge gas and a source gas into a plurality of reactors for a first period, stopping supplying of the source gas, and supplying the purge gas and a reaction gas into the plurality of reactors for a second period, and supplying the reaction gas and plasma into the plurality of reactors for a third period.

Abstract: The present invention relates generally to methods and apparatus for the controlled growing of material on substrates. According to embodiments of the present invention, a precursor feed is controlled in order to provide an optimal pulse profile. This may be accomplished by splitting the feed into two paths. One of the paths is restricted in a continuous manner. The other path is restricted in a periodic manner. The output of the two paths converges at a point prior to entry of the reactor. Therefore, a single precursor source is able to fed precursor in to a reactor under two different conditions, one which can be seen as mimicking ALD conditions and one which can be seen as mimicking CVD conditions. This allows for an otherwise single mode reactor to be operated in a plurality of modes including one or more ALD/CVD combination modes. Additionally, the pulse profile of each pulse can be modified.

Abstract: An object of the invention is to provide a thin film manufacturing device which further reduces a load on a substrate. Provided is a thin film manufacturing device for forming a thin film on a substrate by supplying a mist of a solution including a thin-film forming material to the substrate, characterized in that the device includes: a plasma generation unit including a first electrode and a second electrode disposed closer to one surface of the substrate, which generates plasma between the first electrode and the second electrode; and a mist supply unit which passes the mist between the first electrode and the second electrode and supplies the mist to the substrate.

Abstract: A treatment apparatus includes two can rolls provided on a transfer path through which a long resin film is transferred in a roll-to-roll manner in a vacuum chamber; and surface treatment means facing an outer circumference of each of the can rolls to treat a surface of the long resin film cooled by being wound around the outer circumference. The downstream can roll is provided with upper and lower two sets of feeding and sending systems, and one surface of the long resin film in contact with the outer circumference of the downstream can roll at a time when the long resin film travels through the lower one of the two sets of feeding and sending systems is opposite to the other surface of the resin film in contact with the outer circumference of the downstream can roll at a time when the resin film travels through the upper one.

Abstract: A vortical atomizing nozzle assembly, vaporizer, and related methods are disclosed for substrate processing systems. The vaporizer introduces an atomized or vaporized liquid into a substrate processing system and includes a vaporizer chamber, a nozzle assembly coupled to the inlet for the vaporizer chamber, and a carrier gas channel coupled to the nozzle assembly. The nozzle assembly includes a premix chamber, an outlet channel, and an expanding nozzle. The premix chamber includes a liquid inlet to receive the liquid to be vaporized and a gas inlet to receive the carrier gas. The carrier gas channel is positioned with respect to the gas inlet to cause a vortical flow within the premix chamber upon introduction of the carrier gas through the carrier gas channel. The premixed liquid from the premix chamber is received by the outlet channel and exits the outlet channel into the expanding nozzle.

Abstract: A method of processing a substrate according to a PECVD process is described. Temperature profile of the substrate is adjusted to change deposition rate profile across the substrate. Plasma density profile is adjusted to change deposition rate profile across the substrate. Chamber surfaces exposed to the plasma are heated to improve plasma density uniformity and reduce formation of low quality deposits on chamber surfaces. In situ metrology may be used to monitor progress of a deposition process and trigger control actions involving substrate temperature profile, plasma density profile, pressure, temperature, and flow of reactants.

Abstract: A multi-step process for the anti-corrosive pretreatment of components component formed at least partially from metallic materials wherein first components are subjected to a conditioning wet-chemical treatment with an aqueous composition (A) that contains a salt of a quaternary amine and then to an additional wet-chemical treatment based on water-soluble compounds of the elements Zr, Ti and/or Si, in the course of which treatment a corresponding conversion of the surfaces of the metallic materials takes place, said treatment providing an anti-corrosive primer for additionally applied organic coatings.

Abstract: A graphite-metal carbide-rhenium article of manufacture is provided, which is suitable for use as a component in the hot zone of a rocket motor at operating temperatures in excess of approximately 3,000 degrees Celsius. One side of the metal carbide is chemically bonded to the surface of the graphite, and the rhenium containing protective coating is mechanically bonded to the other side of the metal carbide. Rhenium forms a solid solution with carbon at elevated temperatures. The metal carbide interlayer serves as a diffusion barrier to prevent carbon from migrating into contact with the rhenium containing protective coating. The metal carbide is formed by a conversion process wherein a refractory metal carbide former is allowed to react with carbon in the surface of the graphite. This structure is lighter and less expensive than corresponding solid rhenium components.

Abstract: The joining of hollow aluminum oxide particles and an outer glass layer which is produced, in particular, by means of a heat treatment gives particular corrosion protection for ceramic thermal barrier coatings. Disclosed is a special type of corrosion protection for ceramic thermal insulation layers which is produced by joining hollow aluminum oxide particles and an outer glass layer, which is produced in particular by thermal treatment.

Abstract: An improved marine anode sled comprises a single piece casting with high surface to weight ratio providing increased active surfaces and improved reliability. In one embodiment the anode weighs about 2,000 lbs and has an active surface area of about 5,000 square inches and a current output capacity of up to 160 amps. The improved anode has considerably higher current output than existing anode sleds with similar weight. Unlike known anode sleds, the entire exposed surface of new anode sled is anode material and passes current to a surrounding medium. The single piece casting eliminates structural failure when a frame of know anode sleds is damaged, and electrical failure when cables connecting multiple anodes are damaged. Two redundant lead cable are attached proximal to opposite corners to optimize reliability and electrical performance.

Abstract: An enhanced anode includes a modulated body which improves anode current output efficiency by maximizing the surface area to increase surface area to weight ratio. A toroidally modulated embodiment of the enhanced anode enlarges surface area by 48 percent increasing current output efficiency by 48 percent, only increases weight by three percent, and improves surface/weight ratio 44 percent, compared to know cylindrical anodes. The enhanced anode is preferably made from cast iron or other suitable materials (e.g. magnesium, zinc, aluminum) as well, and the design of the improved anode is applicable to galvanic cast anodes in general. The enhanced anode is suitable for molding and casting and does not increase production costs.