Abstract: Apparatus and methods for use of apparatus for applying targeted stimulation at or adjacent the base of the area of the glans of the penis, wherein the apparatus comprises a contact portion having a first contact surface conforming substantially to the longitudinal profile of the penis, the contact portion further having a second contact surface, raised, in use, inwardly of the first contact surface towards the penis, to project in use into positive engagement with the area at or adjacent the base of the glans of the penis are provided.

Abstract: A footbath has a base member defining a platform. A flexible continuous side wall extends from a proximal end region connected about a periphery of the base member to a distal end region. The side wall has a collapsed position and an extended position. The platform of the base member and the side wall cooperate to define a bath chamber for retaining water with the bath chamber sized to receive a body part. A retention member is supported by the base member to extend from the base member to the distal end region of the side wall to retain the side wall in the extended position.

Abstract: Embodiments of the present invention provide an apparatus for performing quantum reflex integration. A signal generator (106) is configured and disposed to generate an output pattern (220). In embodiments, the pattern may comprise discrete frequency pulses spanning a given frequency range. In some embodiments, the frequency ranges from 1 Hz to 2000 Hz. Embodiments may further comprise a transducer (116) coupled to the signal generator (106), such that the transducer (116) outputs a response that corresponds to the output pattern (220). The transducer may include, but is not limited to, a speaker (114), and an electromagnetic coil. Embodiments may further comprise one or more cold lasers (110). In some embodiments, multiple lasers may be used. Embodiments may include lasers of different wavelengths. In some embodiments, the lasers may include a red laser, a violet laser, and an infrared laser.

Abstract: Low-friction coatings and glass articles with low-friction coatings are disclosed. According to one embodiment, a coated glass article may include a glass body comprising a first surface and a low-friction coating positioned on at least a portion of the first surface of the glass body. The low-friction coating may include a polymer chemical composition. The coated glass article may be thermally stable at a temperature of at least about 260° C. for 30 minutes. A light transmission through the coated glass article may be greater than or equal to about 55% of a light transmission through an uncoated glass article for wavelengths from about 400 nm to about 700 nm. The low-friction coating may have a mass loss of less than about 5% of its mass when heated from a temperature of 150° C. to 350° C. at a ramp rate of about 10° C./minute.

Abstract: A drawer assembly is disclosed that includes a removable container ad a receiving tray. The container has a housing having at least one shaped surface and at least one horizontal alignment element coupled to and projecting from the housing. The receiving tray has a base having a redirection feature and at least one horizontal alignment hole in the base that is configured to accept the horizontal alignment element. The container and receiving tray are configured such that downward motion of the container with the shaped surface of the housing in contact with the redirection feature of the base induces a lateral motion of the container according to the engagement of the shaped surface and the redirection feature that causes the horizontal alignment element to slide into the horizontal alignment hole.

Abstract: A method for blow-fill-seal (BFS) packaging of a product and a BFS package. The method forms a BFS package with a twist-off top, container body and information panel in a main mold. The container is filled via a fill opening located distal to the twist-off top and the fill opening is sealed with a base portion. This provides a container having a twist-off top that is more reliably secured to the container body. A plurality of containers may be attached to a single information panel. The BFS packaging system may employ a quick change insert to reduce lost production time when changing products or lots. The package includes an information panel integrally formed with a plurality of twist-off tops, each of which is removably attached to a container body whereby each container body can be removed from the package without removing the remaining container bodies from the information panel.

Abstract: A device for packaging, conserving, and extemporaneously preparing a plurality of active principles, including a reservoir having a compartment for containing a volume of liquid, the reservoir including a neck defining a dispenser opening; a head that is movable relative to the reservoir between a first distal position for conservation and a second proximate position for preparation; a leaktight closure mechanism; and a rupture mechanism for rupturing the closure mechanism. The closure mechanism is formed by a blister that contains at least two active principles and has at least two compartments, each compartment containing an active principle. The blister is fastened on the neck of the reservoir so as to close it, such that after opening the blister by the rupture mechanism, the active principles enter into contact with the liquid and dissolve therein.

Abstract: A bottle for containing pharmacological and/or nutritional active substances is described. The bottle comprises a closing cap pierceable by the pressure exerted with the luer of a needle-free syringe. The closing cap is made as a single piece including a check valve and closing lips which can be opened by introducing a syringe luer and can be elastically closed back upon the extraction of the luer introduced, and a membrane which is pierceable and elastically resealable to hermetically close the inlet end of the check valve.

Abstract: A container suitable for the preparation, storage and dispensing of compounded suppositories is provided. Methods of preparing, storing and dispensing compounded suppositories utilizing such a container and related kits are also provided.

Abstract: A system for administering a medicament includes a plurality of capsules, a capsule dispenser, and a capsule activator. Each of the capsules includes a reservoir containing a medicament and an outlet in communication with the reservoir through which the medicament exits the capsule. The capsule dispenser releasably contains the ingestible capsules and is adapted to dispense the capsules to a user in accordance with a predetermined schedule. The capsule activator activates the dispensed capsules prior to administration to the user.

Abstract: A smart medication container for providing an automatic, audible playback of recorded and timing information each time it is opened. The smart medication container includes a container base which is an open top container portion and a smart cap connected to the container base through a flexible cord and movable between an open position and closed position. The smart cap includes a sensor for determining when it is removed from the closed position and an audio playback system that plays a prerecorded dosing message and a generated time since last opening message when the smart cap is moved to the open position. The prerecorded dosing message may be stored on a removable storage media so as to allow it to be added, updated or changed by simply providing such a storage media.

Abstract: Medicinal container bags are presented. Bags can include openers capable of sealing an opening of the bag. Disclosed bags further comprise electronic assemblies configured to detect opening or closing events as the openers move along the rims of the bag opening. The assemblies can compile usage data based on opener movement, and then provide the data to remote monitoring systems.

Abstract: A method in which a tube assembly is configured to be used in conjunction with an electromagnetic tube assembly guidance system. The tube assembly includes a first connector, a feeding tube connected to the first connector, a second connector connected to the feeding tube, and a suctioning tube connected to the second connector. The suctioning tube is configured to receive the feeding tube. The feeding tube is configured to allow enteral feeding while the suctioning tube is configured to allow suctioning or decompression of a patient's stomach.

Abstract: Dental adhesives and their uses, for instance an adhesive containing at least one first component A and at least one second component B, characterized in that said at least one first component A comprises a methyl methacrylate, a copolymer of methyl methacrylate dissolved in excess methyl methacrylate, at least one polyfunctional (meth)acrylate and a peroxide-based free-radical initiator, wherein said copolymer of methyl methacrylate is present in an amount of 30-50 parts by weight dissolved in a solution of 65-85 parts by weight of monomeric methyl methacrylate and 3-15 parts by weight of the polyfunctional (meth)acrylate, especially the triethylene glycol dimethacrylate (TEGDMA), mixed with a solution of 0.5 to 3 parts by weight of said peroxide-based free-radical initiator, especially dibenzoyl peroxide, in 70-90 parts by weight of monomeric methyl methacrylate, and said at least one second component B comprises methyl methacrylate and a tertiary amine.

Abstract: A composition comprising a film or a plurality of film fragments entrained in a carrier is disclosed. The film or plurality of film fragments can comprise a functional material. The film or plurality of film fragments can comprise repeated shapes. Also disclosed is a composition comprising a plurality of discernable lamellar fragments entrained in a carrier. Also disclosed is a method for administering a functional material to a human or animal subject in need thereof, the method comprising applying to the subject a composition comprising a film or a plurality of film fragments entrained in a carrier, wherein the film comprises the functional material.

Abstract: A method for the oxidative dyeing of keratinic fibers includes the following steps: applying a cosmetic agent (M1) to the keratinic fibers, allowing agent (M1) to act on the keratinic fibers for a time period of 30 seconds to 40 minutes at a temperature of at least 25° C., applying a cosmetic agent (M2) to the keratinic fibers treated with cosmetic agent (M1), allowing cosmetic agents (M1) and (M2) to act on the keratinic fibers for a time period of 1 to 70 minutes, and rinsing out of cosmetic agents (M1) and (M2). Cosmetic agent (M1) includes at least one oxidation dye precursor of the developer type (M1-1), at least one oxidation dye precursor of the coupler type (M1-2), at least one direct dye (M1-3), and at least one surfactant (M1-4). Cosmetic agent (M2) includes at least one oxidation dye precursor (M2-1) and at least one oxidizing agent (M2-2).

Abstract: A meta-stable composition, a product including the meta-stable composition, and a method of protecting a keratinous substrate from UV radiation by applying the product are provided. The meta-stable cosmetic composition includes at least one water-in-oil emulsifier having a hydrophilic-lipophilic balance (HLB) of less than 6, at least one non-ionic oil-in-water emulsifier having an HLB of greater than 9, at least one ionic surfactant, and at least one skin care active ingredient. The weight ratio of the at least one non-ionic oil-in-water emulsifier to the at least one water-in-oil emulsifier is about 0.02 to about 2.0. The meta-stable cosmetic composition converts from an oil-in-water (O/W) emulsion to a water-in-oil (W/O) emulsion upon rubbing.

Abstract: Disclosed is a water-in-silicone emulsion comprising a discontinuous water phase, a continuous silicone phase, and a silicone polyglucoside containing emulsifier, wherein the discontinuous water phase does not include a salt.

Abstract: The present invention relates to conditioning cosmetic compositions comprising a nanostructured system formed by lipidic nanoparticles based on at least one from oil, butter and wax, which encapsulate at least one cationic surfactant, as well as the use thereof in cosmetic preparations. Besides, the invention relates to a conditioning shampoo comprising said cosmetic composition.

Abstract: Process for heat treating precipitated silica to improve stability. Oral care compositions comprising such heat treated precipitated silica abrasives and a stannous ion source.

Abstract: Disclosed are personal care compositions for use on hair, skin, oral cavity, throat and other mucosal surfaces containing a flavor/perfume system comprising one or more coolants, wherein the pleasant cool and refreshing sensation provided by the coolant is enhanced in terms of quicker onset, greater intensity or impact and/or longer duration, thereby improving appeal and acceptability of the compositions to consumers. In one embodiment the invention provides oral care compositions comprising (a) a flavor composition comprising one or more non-menthol coolants and optionally one or more additional flavor ingredients, (b) a calcium ion source and/or a calcium transport agent sufficient to potentiate and/or modulate the cooling and refreshing sensation provided by the coolant(s), and (c) an orally-acceptable carrier.

Abstract: The ingredient comprises a mixture of unsaturated dicarboxylic acids comprising the Z and E isomers of at least one mono-unsaturated dicarboxylic C12-C24 acid, the concentration of the E isomer being of at least 25% by weight based on the total weight of Z and E isomers. The ingredient can be used to form cosmetic or dermatological compositions, in particular for lightening the skin, improving the clarity and unification of the skin complexion.

Abstract: The invention relates to styling agents, comprising—with respect to the weight thereof—0.1 to 20 wt % of strengthening polymer(s) and 0.1 to 5 wt % of esters of the formula (I), in which R1 stands for —H or CH3, R2 stands for a straight-chain or branched alkyl group having 7 to 15 carbon atoms, and n stands for an integer from the group 1, 2, 3, 4, 5, 6, 7, 8. Said styling agents effect significantly improved curl retention, in particular significantly improved high-humidity curl retention, thus a higher degree of curl retention even in a humid environment in addition to further improved hold and improved hair feel, such as texture and combability.

Abstract: The present invention provides tooth-whitening compositions comprising a bleaching agent and a basic amino acid, together with devices for application thereof, and methods of use therefor.

Abstract: Described herein is a method of dyeing the hair. The method includes applying to the hair a hair color composition including one or more direct dye compounds and rinsing the hair with water. The one or more direct dye compounds each include a yellow chromophore, one or two permanent cations, one to four incipient cations, and one or more hydrophobic moieties. The incipient cations are pendant to the core structure and are neutral. The one or more direct dye compounds enter the hair shaft after the hair color composition is applied to the hair. The hair color composition has a pH of from about 7 to about 11. The pH of the hair after rinsing is from about 3.5 to about 6. The rinsing of the hair causes one or more of the one to four incipient cations to change from neutral to positively charged inside of the hair shaft.

Abstract: The present invention relates to a dentifrice composition which removes a fine stain and a stain adhering to the surface of teeth sufficiently, enhances the whitening effect on teeth and the gloss-imparting effect on teeth, also increases the amount of fluorine adsorption to teeth, and decreases the feeling of astringency. The oral composition of the present invention comprises the following component (A): phytic acid or an alkali metal salt thereof in an amount of 0.04% by mass or more and 1% by mass or less in terms of phytic acid; and component (B): monofluorophosphoric acid or an alkali metal salt thereof in an amount of 500 ppm or more and 1500 ppm or less in terms of fluorine atoms, wherein a mass ratio of the component (A) to the component (B), ((A)/(B)), is 0.1 or more and 1.

Abstract: The present invention relates to a method of shaping a fibrous material and treatment compositions therefor. The method comprises providing a treatment composition comprising an active agent and a photocatalyst, applying the treatment composition to the fibrous material to form a treated fibrous material, mechanically shaping the treated fibrous material, and exposing the treated fibrous material to electromagnetic radiation. The treatment composition comprises an active agent, wherein the active agent comprises a sugar; and a photocatalyst.

Abstract: The present disclosure relates to leave-on hair styling compositions comprising: (a) calcium carbonate: (b) one or more sugar alcohols; (c) one or more thickening polymers; and (d) water. The leave-on hair styling compositions do not require synthetic film-forming polymers nor do they require silicones. The leave-on hair styling compositions are particularly useful in methods for imparting durable styling or shaping benefits, providing volume and fullness, and imparting frizz control to hair.

Abstract: The present disclosure relates to leave-on hair styling compositions comprising: (a) one or more guar compounds: (b) one or more cellulose compounds; (c) one or more glycerol esters of fatty acids; and (d) water. The leave-on hair styling compositions do not require synthetic film-forming polymers nor do they require silicones. The leave-on hair styling compositions are particularly useful in methods for imparting durable styling or shaping benefits and/or frizz control to hair.

Abstract: Methods and compositions for use in tissue volume replacement are provided. The present invention comprises compositions comprising a combination of materials, comprising preferably a solid polymer particle phase and a gel phase, and also comprises single phase compositions. More particularly, preferred embodiments comprise a solid polymer particle phase made of materials comprising Gore-Tex (micronized e-PTFE), PDS II (polydioxanone, a monofilament), NUROLON (a long chain aliphatic polymer Nylon 6 or Nylon 6,6) ETHILON (a long chain aliphatic polymer Nylon 6 and Nylon 6,6), PROLENE (Polypropylene, isotactic crystalline stereoisomer of polypropylene, a synthetic linear polyolefin.), VICRYL (copolymer made from 90% glycolide and 10% L-lactide), silk, MONACRYL (poly ?-caprolactone.

Abstract: The present invention relates to a composition comprising particles of at least one polymer that is surface-stabilized with a stabilizer, the polymer of the particles being a C1-C4 alkyl (meth)acrylate polymer; the stabilizer being an isobornyl (meth)acrylate polymer chosen from isobornyl (meth)acrylate homopolymer and statistical copolymers of isobornyl (meth)acrylate and of C1-C4 alkyl (meth)acrylate present in an isobornyl (meth)acrylate/C1-C4 alkyl (meth)acrylate weight ratio of greater than 4; at least one hydrocarbon-based oil, at least alkyl cellulose, the alkyl residue of which comprises between 2 and 6 carbon atoms; and water. The invention also relates to a process for making up and/or caring for human keratin materials, in which the composition according to any one of the preceding claims is applied.

Abstract: Provided is a mouth rinse composition comprising a phosphate/acrylate co-polymer and an orally acceptable carrier and methods of using the same.

Abstract: The invention relates to a composition in the form of an oil-in-water emulsion and its use that contains in a physiologically acceptable medium, i) at least 0.005% by weight, preferably at least 0.01% by weight, relative to the total weight of the composition, of at least one inulin modified with hydrophobic chains, and ii) at least 0.01% by weight, preferably at least 0.05% by weight, of active substance relative to the total weight of the composition, of at least one hydrophilic acrylic polymer selected from the at least partially neutralized, crosslinked acrylic homopolymers or copolymers, the polyacrylamidomethylpropanesulphonic acid (AMPS) homopolymers and mixtures thereof.

Abstract: A method for dyeing keratin fibers, in particular human hair, in which, after a thickened pretreatment agent (M1) including at least one oxidation dye precursor has been applied and left to act, directly thereafter and without rinsing a coloring agent (M2) is applied and left to act. By virtue of this method, in one dyeing step the hair can be colored and at the same time a multi-tonal dyeing with lighter (“highlights”) or darker (“lowlights”) sections (strands) can be produced.

Abstract: The present invention provides a processed plant product having an excellent TRPM8 activating action, a method for producing the same, and a cooling agent and a TRPM8 activator comprising the processed plant product. A method for producing a processed nutmeg product, comprising a step of simultaneously treating nutmeg or an extract thereof with an alcohol or a 25% (v/v) or more alcohol aqueous solution and one or more selected from a protonic acid and an H-type cation exchange resin.

Abstract: A method for providing a customized skin care product to a customer and skin care kit are disclosed. The method includes obtaining information from a customer regarding current skin conditions, analyzing the information to identify a plurality of target skin conditions in response to the current skin conditions, correlating booster compositions to the target skin conditions, the booster compositions including active ingredients corresponding to the target skin conditions, and assembling a skin care kit, the skin care kit including a base oil composition and a plurality of booster compositions having actives corresponding to the target skin conditions. The base oil composition and plurality of boosters are mixable to obtain a treatment composition at any point in time prior to application to skin.

Abstract: Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods and apparatuses for delivery of zolmitriptan for achieving a Tmax as quick as 2 minutes and not later than 30 minutes in the majority of subjects.

Abstract: The present invention discloses a medicine for treatment or adjuvant treatment of acquired immunodeficiency syndrome, a preparation method thereof and use methods thereof. The medicine comprises: lightyellow sophora root, glabrous greenbrier rhizome, bark of Chinese corktree, raw sessile stemona root, alumen, coptis root, cortex dictamni, chinaberry bark and root-bark, pangolin scales, amber, eucommia bark, tree peony bark, clematis root, common cnidium fruit, Chinese angelica, licorice root, common macrocarpium fruit, barbary wolfberry fruit, medicinal indianmulberry root, cherokee rose fruit, chinaroot greenbier rhizome, akebia fruit, milkvetch root, Japanese climbing fern spore, asiatic pennywort herb, mulberry leaf and frankincense.

Abstract: The present invention relates to biocompatible microemulsion systems designed for controlled release drug delivery applications formulated with phospholipids such as lecithin (surfactant), a lipophilic additive (linker) containing 9 or more carbons in their alkyl group and hydrophilic-lipophilic balance (HLB) of 5 or less, and a surfactant-like hydrophilic additive (linker) containing between 6 to 9 carbon atoms in their alkyl tail. The combination of linkers and phospholipids produce formulations capable of delivering high concentrations of poorly soluble drugs into epithelial tissue using low surfactant concentrations, with minimum cytotoxic side effects.

Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).

Abstract: The present invention provides a pharmaceutical composition in a powder form for providing wound protection, hemostasis, or anti-adhesion in the gastrointestinal tract, which comprises a certain mucoadhesive polymer; and a certain hygroscopic agent.

Abstract: An object of the present invention is to provide a method for producing selectively a powder particle consisting of the ?-form crystal of D-mannitol, using the spray-drying method. It is a method for selective production of powder particles consisting of the ?-form crystal of D-mannitol, wherein a D-mannitol solution containing a water-soluble polymer is spray-dried.

Abstract: Disclosed are pharmaceutical compositions comprising a compound having the formula: or a pharmaceutically acceptable salt thereof, or a hydrate of thereof, and at least one pharmaceutically acceptable polymer. The pharmaceutically acceptable salt of the compound of Formula I, or a hydrate thereof, can be a mesylate salt, including, for example, a mono-mesylate or a bis-mesylate salt, or a hydrate thereof. Also disclosed are methods of use for the pharmaceutical composition.

Abstract: A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.

Abstract: Method for producing enteric microcapsules without coating, containing diclofenac or one of the salts thereof with satisfactory anti-inflammatory activity and low gastric aggressiveness; and a pharmaceutical composition containing them. The method comprises a) preparing a mixture in water-ethanol with an alginate salt, adding diclofenac or one of the salts thereof previously diluted with a surfactant and sodium bicarbonate; b) adding the previous solution to a solution with a calcium salt; c) resuspending the microcapsules obtained and isolated in an aqueous solution of the alginate salt; and d) isolating, drying and sieving through 1000 and 250 micron meshes the microcapsules obtained; and selecting the fraction comprised between both meshes. The pharmaceutical composition can be an oral composition, tablets, chewable tablets, or a powder for suspension in water.

Abstract: The disclosure relates to substantially uniform, high density microspheres and methods of making the microspheres. The microspheres can be made to be small in size with a narrow range of particle size distribution and a high sphericity. In one aspect, the microspheres provided herein are provided in the form of spherical cores comprising maltodextrin or maltodextrin and starch and are prepared using a centrifugal tumbling-granulating-coating apparatus. In another aspect, the spherical cores can be powder-coated with one or more layers of small particles, such as starch particles. The microspheres provided herein can be used as cores for multi-particulate solid dosage delivery systems as well as other pharmaceutical, nutraceutical, food, personal care, and other applications.

Abstract: Systems and methods are provided for the removal of endotoxins from fluids. The methods can include the use of polymeric nanoparticles for binding endotoxins present in a fluid. The polymeric nanoparticles can be associated with a support member. The polymeric nanoparticles can have an endotoxin removal capacity of at least 1×109 endotoxin units per gram of polymeric nanoparticle (EU/g) and/or a removal efficacy per unit surface area of the polymeric nanoparticles of at least 1×106 EU/cm2.

Abstract: A method of forming a membrane on a patch of skin using a gel, for the purpose of protecting the skin area or administering pharmacologically active substances to or through the skin area. The main ingredients of the gel are an alkyl acrylate crosspolymer such as Carbopol Ultrez 20 and a water soluble polymer such as polyvinylpyrrolidone (PVP). The gel may also contain other ingredients such as water, ethanol, antioxidants, lubricants, and neutralizers. The gel has the properties of being colorless and clear, low skin and nose irritability, easy to administer, fast membrane forming time, and removable by washing with water.

Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer satisfies the following two conditions: 5 to 13.2% by mass relative to a total mass of the adhesive agent layer, and 0.12 to 2.7 mg/cm2 per unit area of the adhesive agent layer.

Abstract: A petrolatum composition comprises from 10 to 60 wt % of a wax having an average number of carbon atoms per molecule of between 25 and 70, and having between 5 and 50 wt % branched paraffins in which the branches are selected from methyl and ethyl branches; from 10 to 60 wt % of a linear paraffin having an average number of carbon atoms per molecule of between 10 and 20; and optionally, a low melt wax. The petrolatum composition has a drop melt point of from 35° C. to 80° C.