Abstract: A bed supporting device adapted to be installed to a bottom seat of a bed includes a leg unit; a first link board connected to an upper end of the leg unit, and formed with a first through hole; and a second link board for connection to the bottom seat, installed on the first link board and formed with a second through hole corresponding to the first through hole; wherein, either the first or second through hole is elongated such that a fixing screw can extend through the first and second through holes in the first and second link boards for coupling a fastener, thereby immobilizing the first and second link boards.

Abstract: A method for alleviating the dizziness symptoms of a person suffering from benign paroxysmal positional vertigo comprising the steps of: positioning the head of the person on a head-rest device that is formed of a first pillow structure; a second pillow structure with at least one slanted surface; and a non-permanent fastener on at least one surface of the first pillow structure and one surface of the second pillow structure so that the first and the second pillow can be placed in a user-selected configuration one on top of the other and the relative positions of the first pillow structure to the second pillow structure is fixed by the non-permanent fastener. The second pillow structure overhangs the first pillow structure so as to define an overhang region. The method includes the step of adjusting the second pillow structure so as to position a sleeping surface of the second pillow structure at an angle between about 20 degrees and 60 degrees relative to a horizontal reference surface.

Abstract: A bedpan assembly includes a bedpan that may be placed on a bed. Thus, a bedridden user may urinate and defecate into the bedpan. A cushion is coupled to the bedpan and the cushion enhances comfort of the bedridden user. A valve is coupled to the bedpan to receive the bedridden user's urine. The valve is selectively positioned between an open position and a closed position. Thus, the valve inhibits the urine from back splashing onto the bedridden user.

Abstract: A patient support structure includes a pair of independently height-adjustable supports, each connected to a patient support. The supports may be independently raised, lowered, rolled or tilted about a longitudinal axis, laterally shifted and angled upwardly or downwardly. Position sensors are provided to sense all of the foregoing movements. The sensors communicate data to a computer for coordinated adjustment and maintenance of the inboard ends of the patient supports in an approximated position during such movements. A longitudinal translator provides for compensation in the length of the structure when the supports are angled upwardly or downwardly. A patient trunk translator provides coordinated translational movement of the patient's upper body along the respective patient support in a caudad or cephalad direction as the patient supports are angled upwardly or downwardly for maintaining proper spinal biomechanics and avoiding undue spinal traction or compression.

Abstract: An exercise training apparatus attached to a trainee who performs a body exercise training, includes movable bodies, actuators, sensors and a processor. The movable bodies each having a fixed member which a part of a trainee's body is fixed to and exercising a trainee's extremities by rotating around shafts, respectively. The sensors each detecting a physical quantity that changes depending on force applied to the fixed members by a trainee. The processor, in response to a detection of a predetermined change in a physical quantity by the sensors, driving the actuators, rotating the movable bodies in a first direction and successively rotating the movable bodies in a second direction opposite to the first direction.

Abstract: A stretching device comprises a wearable body harness with an adjustable central hold arranged around the upper body connected with an adjustable extension strap configured to engage a foot at a distal end. The extension strap is slidably connected to the central strap to move along the length of the central strap. The extension strap comprises a non-elastic material, divided by a single elastic segment. The extension strap having incremental markings designating amount of adjustment. The device and method of using the device provides a comfortable tension, facilitates hands free stretching in the supine position, improving duration of stretching and range of motion. An independent adjustable stretching strap for upper body and shoulder stretching, further comprises a non-elastic material looped at each distal end, divided by a discrete elastic segment and having incremental visual markings designating amount of adjustment.

Abstract: A stimulation device is provided in accordance with one embodiment. The stimulation device includes a chamber which has a flexible wall portion. A drive unit of the stimulation device is in physical communication with the flexible wall portion so as to cause deflections of the flexible wall portion in opposing directions, thereby resulting in a changing volume of the chamber. The changing volume of the chamber results in modulated positive and negative pressures with respect to a reference pressure. An opening of the stimulation device is for applying the modulated positive and negative pressures to a body part. An appendage of the stimulation device may be used as a handle to allow a user to position the stimulation device over the body part. The stimulation device includes a control device for controlling the drive unit.

Abstract: A spa jet replacement system uses a hollow tubular positioning sleeve having an opening located proximate a first end thereof. A spa jet is inserted into the first end of the sleeve and the sleeve is inserted into the nozzle system of a spa until the opening of the sleeve aligns with an air inlet of the nozzle system, thereby positioning the spa jet upstream of the air flow of the spa fluid system. The outside diameter of the sleeve approximates the pipe(s) of the nozzle into which the sleeve is inserted so that the sleeve is friction held in place after insertion. A longitudinal slit may be located on the sleeve for ease of insertion.

Abstract: An article is described including an article surface and a coating set comprising an optional tie coating or layer, a barrier coating or layer, and a pH protective layer. The respective coatings or layers can be applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. Examples of such an article are a prefilled thermoplastic syringe or thermoplastic pharmaceutical vial with a coated interior portion containing a pharmaceutical preparation or other fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic syringe or vial. The tie coating or layer, if present, and the pH protective coating or layer protect the barrier layer from the contents of the syringe or vial.

Abstract: A pharmaceutical order filling system receives pharmaceutical orders and uses a loading device to label containers and load the labeled containers onto a pallet. The loading device is configured with at least one container drop assembly that receives containers to be labelled and loaded onto the pallet and that is in communication with a label assembly configured to print and apply labels to the containers. The loading device also includes at least one loading rotary wheel configured to receive the labelled containers and hold the labelled containers in a pick position to be moved from the pick position to a predetermined position on the pallet. The loading device may be configured to accommodate multiple sizes of containers and to consolidate multiple sizes of labelled containers into a single loading rotary wheel for loading onto the pallet.

Abstract: A portable medicine feeder includes at least two medicine boxes placed in juxtaposition to be integrally arranged. Each medicine box has an accommodation portion and block walls perpendicularly extending upwards from a bottom of the accommodation portion wherein at least one block wall is shared. A gradually-reduced guide channel extends forwards and upwards from the bottom of the accommodation portion. An included angle of at least 120 degrees is defined between the slope of the gradually-reduced guide channel and the bottom of the accommodation portion so that an outlet formed at a front end of the gradually-reduced guide channel has a width much smaller than that of the accommodation portion. A gap is formed between the adjacent outlets of the adjacent medicine boxes. The gap and the gradually-reduced guide channel can go into the corner of the mouth and the lower lip of the taker.

Abstract: The invention relates to a self-expandable tube having a catheter body with a double lumen in which one lumen allows for suctioning or decompression and another lumen for a feeding tube. A self-expandable portion collects secretions above the expandable portion or in the anatomical lumen and a suction source coupled to the self-expandable tube removes the secretions as is disclosed herein.

Abstract: The emesis receptacle is a container that is adapted for use in receiving and storing discharge of emesis. The emesis receptacle is designed to receive the discharge with a minimum of spillage. The emesis receptacle further provides storage areas for the purpose of containing domestic articles necessary for maintaining comfort and cleanliness throughout the discharge process. The emesis receptacle comprises a hollow container, a plurality of handles, one or more pockets, a drawer, a false bottom, and a chin extension. The plurality of handles, the chin extension, and the one or more pockets are attached to the container. The drawer is installed within the container. The false bottom is positioned within the container such that the false bottom protects the contents of the drawer from the discharge of emesis.

Abstract: The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.

Abstract: The invention provides a high strength dental composition including polymerizable dental resins. The dental composition is useful as restorative material and for making various dental devices, such as artificial teeth, crowns and bridges of high strength dental polymeric material.

Abstract: The invention relates to a kit of parts comprising part A and part B, part A comprising a polymerizable component having an acid group in the molecule, an initiator, part B comprising an activator, and a film former with a molecular weight of at least 1000. The invention also relates to a composition obtainable by mixing the components contained in the kit of parts and to a process for producing the kit of parts comprising the steps of bringing the components contained in part B of the kit in contact with a surface, drying the surface to form a film.

Abstract: Provided is a fluoroaluminosilicate glass powder that can provide a dental glass ionomer cement hardened body excellent in acid resistance, the glass powder including sodium and potassium which have an effect of lowering the reflective index of glass. A mass ratio of potassium to sodium in the component is in the range of from 1.2 to 1.9 in terms of oxide.

Abstract: A wet wiper for cleaning accumulated oral debris from removable dental appliances. The wet wiper comprises a water insoluble substrate and a physiologically acceptable cleansing composition, wherein the cleansing composition comprises: (i) a liquid carrier consisting of a solution of water and ethyl alcohol, wherein the ethyl alcohol is about 3% to about 90% by weight of the cleansing composition, and wherein the water is q.s. to 100%; and (ii) about 0.001% to about 5% by weight of the cleansing composition of a flavor. Methods for cleaning removable dental appliances are also provided, such methods comprising the step of contacting, for a time sufficient to reduce oral debris, the removable dental appliances, with a wet wiper of the present invention.

Abstract: A particle comprising:—(a) a spacer which is a polyethylene glycol (PEG) chain with molecular weight Mw (and therefore the required length) of the spacer extending from the particle from 3000 to 400,000; (b) a deposition aid; and (c) a benefit agent, wherein the spacer is attached directly to the particle and the deposition aid is attached to the end of the spacer.

Abstract: The present invention concerns a translucent gel system, notably a hair conditioner gel, comprising at least a carboxylic acid, an alkoxylated alkyl or alkenyl amine and a cationic surfactant. Such a translucent gel system provides an excellent conditioning effect for washing skin and/or hair and a high transmittance.

Abstract: A consumer product comprises: (a) a porous dissolvable solid structure, (b) a first hydrophobic coating comprising a first benefit agent, and (c) a second hydrophobic coating comprising a second benefit agent. The first and second hydrophobic coatings are discretely applied to the porous dissolvable solid structure. A method of forming an aqueous treatment liquor comprises the steps of: (a) providing a consumer product, (b) providing an aqueous solution, and (c) dissolving the consumer product in the aqueous solution to form an aqueous treatment liquor comprising a hydrophobic portion and an aqueous portion.

Abstract: Zinc oxide compositions as well as techniques for doping ZnO particles for sunscreen applications are provided herein. A method includes selecting one or more dopants to be incorporated into one or more zinc oxide particles in a sunscreen composition, wherein the one or more dopants comprise chromium, cobalt, gallium, and/or tin, and wherein said selecting is based on one or more optical properties associated with each of the dopants, and incorporating the selected dopants into the zinc oxide particles to create the sunscreen composition. A composition includes multiple zinc oxide particles suspended within a medium forming sunscreen composition, and one or more dopants incorporated into each of the multiple zinc oxide particles, wherein the one or more dopants comprise chromium, cobalt, gallium, and/or tin, and wherein each of the dopants imparts one or more optical properties to the zinc oxide particle within which the dopant is incorporated.

Abstract: A solid stick antiperspirant composition is provided. The antiperspirant composition includes aluminum zirconium tetrachlorohydrex glycine having a concentration from about 10% to about 35% by weight of the composition, an anhydrous liquid carrier, one or more structurants having a concentration from about 15% to about 25% by weight of the composition, wherein the one or more structurants comprises one or more waxes and a non-ionic exthoxylated linear alcohol having a carbon chain length from about 20 to about 40. The solid stick antiperspirant composition is a single phase.

Abstract: An object of the present disclosure is to investigate fluorescent substance being safe and having a high color developing property, and obtain an inorganic red fluorescent substance consisting of an element which exerts no bad influence upon human bodies. A cosmetic containing inorganic particles consisting of a compound represented by a general formula: MgxTiyO(x+2y+2z):Mn4+z wherein 1.5<x<2.5, 0.5<y?1.5, and 0.0001<z<0.1.

Abstract: Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.

Abstract: Described herein are oral care compositions comprising a whitening agent having the formula: R1—O—O—R2; and an aliphatic ketone; wherein R1 and R2 are independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 carbonyl, SO3, and phenyl; and methods of making and using the same.

Abstract: A method of reducing hair loss (alopecia) in a patient undergoing or scheduled to undergo chemotherapy is claimed. The method involves administering brimonidine or a pharmaceutically acceptable salt thereof to the site of the hair follicles.

Abstract: Compositions of the present invention include an anionic surfactant, a zwitterionic surfactant, a superhydrophilic amphiphilic copolymer, an organic acid; and a polymer selected from the group consisting of a non-hydrophobically modified alkali-swellable emulsion polymer and a non-crosslinked hydrophobically modified acid-swellable emulsion polymer, wherein, when the composition contains the non-hydrophobically modified alkali-swellable emulsion polymer, the non-hydrophobically modified alkali-swellable emulsion polymer is present in an amount of about 0.1% to 5% by weight, and when the composition contains the non-crosslinked hydrophobically modified acid-swellable emulsion polymer, the non-hydrophobically modified acid-swellable emulsion polymer is present in an amount of about 0.1% to 5% by weight, and wherein the composition has an NTU value of 95 or less, a yield value of about 0.1 Pascal or more and pH of from about 3 to about 6.5.

Abstract: Disclosed are compositions and methods for their use that can be used individually or in combination. The compositions have the ability to treat a wide range of skin and skin conditions, and particularly men's skin.

Abstract: This document relates to methods and materials involved in providing a tooth, tooth component, or inorganic dental material (e.g., a human tooth, a human tooth component, or an inorganic dental material within a human's mouth) with a white appearance. For example, a whitening adhesive containing a conjugate of at least a polyamine, a polyphosphate, and one or more whitening agents (e.g., titanium dioxide, zinc oxide, and/or hydroxyapatite) can be used to provide a tooth, tooth component, or inorganic dental material with a whiter appearance.

Abstract: The present invention relates to a formulation for external application to the skin containing tacrolimus, which is a poorly soluble drug used as a second therapeutic agent for atopic dermatitis and, more specifically, to a composition of a hydrophilic external gel formulation capable of enhancing skin permeability of tacrolimus, and a preparation method therefor. The hydrophilic external gel formulation loaded with tacrolimus of the present invention is in an easily preparable practical form with excellent moisturizing performance, and is excellent in spreadability and has improved drug delivery, skin permeability and skin residual capacity when applied to the skin, compared to conventional ointments, and thus can be usefully used for the treatment of atopic dermatitis and other immune diseases.

Abstract: The present invention provides a pharmaceutical composition for delivering palonosetron through the buccal mucosa or sublingual mucosa. The pharmaceutical composition comprises 0.05-35% (w/w) of palonosetron, 40-90% of a film forming agent, 1-10% (w/w) of a plasticizer, 5-25% (w/v) of an adhesive agent, and 0.1-5% of a penetration enhancing agent. A preferred plasticizer is a polysorbate. A preferred adhesive agent is polyvinylpyrrolidone or carboxymethylcellulose. A preferred penetration enhancing agent is peppermint oil or menthol.

Abstract: A dissolvable film for delivering a pharmaceutical agent comprises a first water soluble polymer in an amount of from 2 to 35 weight percent and having a molecular weight from about 5,000 daltons to about 49,000 daltons; a second water soluble polymer in an amount of from 2 to 35 weight percent and having a molecular weight greater than 60,000 daltons; and a pharmaceutically active ingredient. The film has a thickness of about 20 microns to about 1200 microns and is configured to disintegrate after contact with a mucous membrane and thereby release the active ingredient.

Abstract: Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

Abstract: The invention provides intradialytic parenteral nutrition (IDPN) solutions with low carbohydrate for the treatment of malnutrition in dialysis patients. The IDPN solutions of the invention are particularly advantageous for the treatment of malnutrition in patients who are diabetic or suffer from other glucose management related pathologies or patients who require strict fluid management.

Abstract: Disclosed herein are methods, processes, compositions, and kits for generating bone graft materials for use at a site of bone defect that utilizes a composition which contains liposomal Wnt polypeptide, such as liposomal Wnt3a polypeptide, liposomal Wnt5a polypeptide, or liposomal Wnt10b polypeptide. Also disclosed herein are methods, processes, compositions, and kits for enhancing mammalian bone marrow cells that utilizes a composition which contains liposomal Wnt polypeptide, such as liposomal Wnt3a polypeptide, liposomal Wnt5a polypeptide, or liposomal Wnt10b polypeptide.

Abstract: An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.

Abstract: Provided herein are methods and compositions for the delivery of bioactive compounds to a cell, tissue, or physiological site. The compositions comprise delivery system complexes comprising liposomes encapsulating a biodegradable ionic precipitate having incorporated therein a bioactive compound and delivery system complexes comprising a biodegradable ionic precipitate ionically bound to a surrounding lipid bilayer, wherein the biodegradable ionic precipitate comprises a bioactive compound. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering the delivery system complexes comprising bioactive compounds that have therapeutic activity against the disease or unwanted condition to the subject.

Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

Abstract: Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or IOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.

Abstract: Co-agglomerates of crystalline mannitol and granular starch, characterized in that they have a compressibility, as determined according to a test A, higher than 120 N, and preferably of 200 to 450 N, and a flow time, as determined according to a test B, of 3 to 15 seconds, and preferably of 4 to 8 seconds.

Abstract: A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).

Abstract: The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.

Abstract: The present invention provides compositions suitable for topical administration to a mammalian subject including sodium hyaluronate and a pharmaceutically acceptable excipient. The present invention also provides methods for making and using the same.

Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.

Abstract: Methods of preventing, ameliorating and/or treating radiation induced gastrointestinal tract injury comprising the administration of a therapeutically effective amount of Mesna to a patient are provided. Methods for preventing, treating and/or ameliorating gastrointestinal tract injury induced by radiation therapy, alone or in combination with other therapies for diseases or conditions such as gastrointestinal malignancies, urogenital malignancies, gynecologic malignancies, and osteogenic and other sarcomatous malignancies in which pelvic structures are involved.

Abstract: Compositions and methods that are useful for treating a subject suffering from one or more cancers are provided herein. Such compositions and methods can contain an effective amount of magnesium threonate to be used to support or improve the mental state of a subject. The composition and methods comprising magnesium threonate can also be used to support a cancer treatment.

Abstract: The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.

Abstract: ?-Substituted ?-amino acids, ?-substituted ?-amino acid derivatives, and ?-substituted ?-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The ?-substituted ?-amino acid derivatives and ?-substituted ?-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the ?-substituted ?-amino acid derivatives and ?-substituted ?-amino acid analogs and (bio)isosteres and methods of using the compounds for treating tumors are also disclosed. The ?-substituted ?-amino acid derivatives and ?-substituted ?-amino acid analogs and (bio)isosteres exhibit an improved selectivity toward tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo.

Abstract: The present disclosure includes a formulation of branched chain amino acids and arginine for treatment of diseases for which the pathological mechanism includes autophagy. The formulation includes defined ratios of the branched chain amino acids Isoleucine, Leucine, and Valine along with Arginine. These disease indications include congestive heart failure, myocardial infarction, and ischemia reperfusion injury. Diseases of other organs that involve autophagy are also disclosed. Additionally, methods of using the disclosed formulation to treat these disease indications are provided. The disclosure also describes a kit that includes a lyophilized form of the formulation, a solvent for reconstitution, and instructions directing reconstitution.