Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

Abstract: The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.

Abstract: The invention relates to a genetically encoded fluorescent sensor for nicotinamide adenine dinucleotide, as well as methods of preparation and uses thereof. In one aspect, this invention relates to a sensor for detecting nicotinamide adenine dinucleotide, particularly, a recombinant fluorescent fusion protein sensor for detecting nicotinamide adenine dinucleotide. In one specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting reduced nicotinamide adenine dinucleotide (NADH); in another specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting oxidized nicotinamide adenine dinucleotide (NAD+); in yet another aspect, the invention relates to a recombinant fluorescent fusion protein sensor for detecting the ratio of reduced to oxidized nicotinamide adenine dinucleotide.

Abstract: The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising the steps consisting of i) determining the density of B cells at the invasive margin of the tumor (im) in a tumor tissue sample obtained from said patient, ii) comparing said density with a predetermined reference value and iii) providing a good prognosis when the density of B cells at the invasive margin of the tumor is higher than the predetermined reference value and a poor prognosis when the density of B cells at the invasive margin of the tumor is lower than the predetermined reference value.

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer.

Abstract: Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.

Abstract: The present disclosure provides synthetic antibodies specific for a disease-associated antigen, and methods of using the antibodies in disease therapy. The present disclosure further provides diagnostic assays involving detecting the presence and/or level in biological sample of an antibody specific for a disease-associated antigen.

Abstract: Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.

Abstract: Disclosed herein is a protein standard for gel electrophoresis. The standard may be detected using multiple modalities. These modalities include, for example, observation of color or fluorescence arising from dyes, porphyrins, or haloalkylated tryptophan residues covalently linked to proteins of the standard; or detection of fluorescence or chemiluminescence arising from antibodies or other binding partners bound to proteins of the standard through polypeptide epitopes or affinity tags. The protein standard comprises multiple protein sets, each set corresponding to a different gel band, and proteins within a set may be detectable with one or more modalities.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: The invention comprises a method for determining degree of modified potency of a bipathic medicament. A bipathic medicine is a medicament comprising a therapeutic component and a homeopathic component, wherein the homeopathic component has some physical, chemical or biological affect on the therapeutic component and/or the pharmacological efficacy thereof. An analytical measurement of at least one characteristic parameter of the therapeutic form is made prior to its interaction with the activated-potentiated form. The same analytical measurement(s) are made and after interaction between the therapeutic and activated-potentiated forms. This data is used to confirm the presence of any modified potency is caused by the presence of molecular form in the activated-potentiated form.

Abstract: Herein is reported a method for the detection of free antigen of a multispecific antibody in a sample, whereby the antigen to be detected can be specifically bound by a first binding site of the multispecific antibody, comprising the step of incubating a sample comprising free antigen and multispecific antibody with an anti-idiotypic antibody, which specifically binds to a second binding specificity of the bispecific antibody, which is different from the first binding specificity, whereby the anti-idiotypic antibody is bound to a solid phase.

Abstract: Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent and for determining whether an individual is maintaining responsiveness to an anti-CD47 agent by assaying biological samples for the level of at least one biomarker in a biological sample.

Abstract: The present invention relates to a method for assessing a subject's risk of having a cardiovascular disease comprising the step of measuring the level of IF1 in a body fluid sample obtained from said subject wherein the level of EF1 is negatively correlated with the risk of said subject of having cardiovascular disease.

Abstract: Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions.

Abstract: The present invention relates to methods and kits for predicting the risk of respiratory failure, renal failure or thrombopenia in a septic patient. More particularly, the present invention relates to a method for predicting the risk of having an organ failure selected from the group consisting of respiratory failure, renal failure and thrombopenia in a septic patient comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said septic patient.

Abstract: The present invention relates to a marker which can be used to diagnose a diabetic retinopathy patient and determine the progression of diabetic retinopathy, a composition for diagnosing diabetic retinopathy, which comprises an agent for measuring the level of a gene or protein associated with the marker, and the use thereof.

Abstract: Methods, compositions, and kits for determining whether a subject has non-alcoholic fatty liver disease (NAFLD) are provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatosis are also provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatohepatitis (NASH) are also provided.

Abstract: The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth disease (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow-up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease subtypes and assessing the responsiveness to treatments and the efficacy of treatments in subjects having CMT or a related disorder.

Abstract: Immunoassay methods and their requisite components for the detection and determination of phenethylamines of the 2C and DO sub-families are described.

Abstract: Various embodiments for a hand-held device to determine a level of one or more cannabinoid compounds in exhaled human breath are provided; some embodiments may also determine a level of alcohol in the exhaled breath. The device may perform any of the following steps: capture, concentrate, separate, identify, and quantify the level of cannabinoids in the exhaled human breath. The device may use solvent extraction and liquid chromatography to concentrate and separate cannabinoids from breath contaminants, followed by selective chemical modification of the cannabinoids with a fluorescent indicator for quantification. The measurement methodology may also include real time calibration of the device and detection protocol using known cannabinoid standards, which are simultaneously analyzed along with an unknown, to quantify the level of cannabinoids captured from the breath sample.

Abstract: A cell smearing apparatus comprising: a mixed solution container accommodation unit accommodating a mixed solution container containing a mixed solution of cells and a preservation solution; a suction unit suctioning the mixed solution from the mixed solution container accommodated in the mixed solution container accommodation unit; a sensor unit sensing variation of the mixed solution suctioned by the suction unit; and a controller controlling a suctioning speed of the suction unit based on a value sensed by the sensor unit. The present invention allows cells to be examined to be smeared as a monolayer on a slide for microscopic examination.

Abstract: According to one embodiment, an automatic analyzer includes a magnetic field generator, a photometric unit, a measurement unit, and a decision unit. The magnetic field generator causes magnetic separation in a reaction liquid stored in a cuvette by magnetic particles. The photometric unit includes a light source unit configured to generate light, and a detection unit configured to detect the light generated by the light source unit and generate an output signal corresponding to the detected light. The measurement unit measures a measurement item based on the output signal. The decision unit decides the use range of the output signal to be used to measure the measurement item in accordance with spatial unevenness of the magnetic separation by the magnetic field generator.

Abstract: After an analysis start instruction is input in a state where a sample is not dispensed to all of reaction containers 104 mounted on a reaction disc 105, before completing an analysis preparation washing process for washing the reaction container 104 to be used in analyzing the sample to be first analyzed, a soaking and washing process for performing soaking and washing during a predetermined period of time is controlled to be started by dispensing a soaking and washing detergent to another reaction container 104 different from the reaction container 104. In this manner, the soaking and washing can be efficiently performed on the reaction container without hindering an analysis process.

Abstract: ABSTRACT The present invention lies in the field of automated analysis apparatuses and relates to a method for transferring a liquid volume from a first liquid vessel into a second liquid vessel. The method ensures increased pipetting accuracy, even from liquid vessels which have foam on the surface of the liquid.

Abstract: A pipetting system includes a rail; a carriage to engage the rail, the carriage movable relative to the rail substantially along a first axis; a pipette pump slidably engaged with the carriage, the pipette pump slidable relative to the carriage substantially along the first axis; and a sensor to detect movement of the pipette pump relative to the carriage.

Abstract: According to an embodiment, a method of measuring wind speed includes measuring atmospheric pressure at a first pressure sensor arranged inside a case and shielded from wind, measuring air pressure at a second pressure sensor arranged at an opening in the case, and determining wind speed at the opening in the case based on measuring the atmospheric pressure and the air pressure.

Abstract: An adjustable clamping device for mechanical and electrical connection to sides of a conductor includes a first clamping member having a first base and a first arm, a second clamping member having a second base and a second arm, and a coupling member configured to adjustably couple the first clamping member with the second clamping member such that the first arm is spaced from the second arm by a desired distance. The coupling member is also configured to prevent decoupling of the first clamping member from the second clamping member.

Abstract: An electrical current detection device is provided with a shunt resistor that includes a first conducting part, a second conducting part, a center conducting part disposed between the first conducting part and the second conducting part, a first resistor disposed between the first conducting part and the center conducting part, and a second resistor disposed between the second conducting part and the center conducting part, the second resistor having a greater resistance value than the first resistor. The electrical current detection device is further provided with: a signal output unit; an estimation unit that estimates a first estimated current value from the first detection signal, and estimates a second estimated current value from the second detection signal; and an determination unit that compares the first estimated current value and the second estimated current value, and determines the abnormality of the shunt resistor.

Abstract: A measuring apparatus has a physical amount transformer that transforms a physical amount into a current, a measuring circuit that measures an output current of the physical amount transformer, a power supply circuit that inputs an output of the measuring circuit, a circuit switching unit that switches between a first state and a second state, the first state constituting a circuit inputting the output of the measuring circuit into the power supply circuit, the second state constituting a circuit directly inputting the output of the measuring circuit into the physical amount transformer, and a switching controller driven by the power supply circuit to control the circuit switching unit.

Abstract: A high output voltage VOH level and a low output voltage VOL level parametric test system may include test circuitry coupled to output nodes of input/output (I/O) driver circuits. The test circuitry may source and sink current to the output nodes while the I/O driver circuits are in pull down and pull up states, respectively, in order to generate output voltages on the output nodes. The parametric test system may compare the output voltages with a plurality of high and low reference levels to determine ranges of the output voltages. The ranges may be used to determine whether the I/O driver circuits pass the VOH and VOL test requirements. The VOH/VOL test system may be implemented on-chip with other components of the external device, which may eliminate the need to perform other parametric testing with external test equipment.

Abstract: A method detects power theft in a branch of a distribution system by distinguishing between technical losses that are inevitable during the course of normal operation of the system, and non-technical losses that can be attributed to power theft. The method assumes a specific circuit corresponding to that branch, collects data for energy consumed and currents at regular intervals by means of a smart or traditional power meter, estimates the likely resistances of the lines connecting the consumption points to the distribution transformed by means of least squares regression, and uses the estimated resistances to predict technical losses in future time intervals. By comparing the total power losses measured during future intervals with the estimates of the technical losses, the amount of non-technical losses can be estimated, and theft can be signaled when this amount is unusually high.

Abstract: In a method for monitoring power, preset information that defines periods in which one or more preset electric devices are scheduled to operate is received, an amount of power available, which is an estimated amount of power available in the building in each period, is calculated, estimated power consumption, which is estimated power consumption in the building in each period, is calculated using power consumption information, to which power consumption of the electric devices to be preset is registered in advance, and the preset information, an alternative instruction with which the estimated power consumption becomes lower than or equal to the amount of power available is generated, and the alternative instruction is displayed on a terminal apparatus. And at least one of the receiving, the calculating the amount of power available, the calculating the estimated power consumption, the generating and the displaying is performed by a processor.

Abstract: A charge measuring device detects focused ion beam attacks on an integrated semiconductor circuit with a capacitor, a field effect transistor, and a charge collecting device all manufactured in the integrated semiconductor circuit and insulated from additional circuit elements. A first pole of the capacitor is conductively connected to the charge collecting device and a gate of the field effect transistor. When a voltage is applied to the second pole of the capacitor, a drain source current flows through the field effect transistor, and a relationship between the voltage and the drain source current is ascertained. A comparison of the relationship with a previously ascertained relationship indicates a change of the charge quantity stored in the capacitor by the charge collecting device.

Abstract: An illustrative wire processing machine includes at least one blade configured for at least one of cutting a conductor or at least piercing an insulation layer on the conductor. At least one gripper assembly includes a gripper configured to at least temporarily grasp a portion of a conductor during a wire processing operation. A generator, which is part of the gripper assembly, is configured to radiate a field toward a conductor. The gripper assembly also includes a detector that is configured to detect at least some of the field propagated along the conductor. A processor is configured to determine when a change in the propagated field detected by the detector indicates contact between a conductor and the blade.

Abstract: A programmable logic circuit assigns a value to an outlet of a power distribution unit (PDU) that comprises a power source at an input of the PDU and at least one light-emitting diode (LED) associated with the outlet. The programmable logic circuit sends the value to a program on a hardware device that comprises one or more power supplies. The programmable logic circuit receives information from the program. Subsequently, an illumination state of the LED is modified based on the information.

Abstract: The present disclosure provides systems and methods for detecting arc faults. For some embodiments, arc faults are detected from waveforms that are acquired and processed, preferably using an Average Magnitude Difference Function (AMDF). The characteristics of the waveform provide an indication of whether or not an arcing fault occurred.

Abstract: An antenna checking circuit includes an antenna-connection-input terminal, a check-request-input terminal, a check-result-output terminal, a switching element having a control end connected to the check-request-input terminal, an input end connected to the antenna-connection-input terminal, and an output end connected to the check-result-output terminal, and a first resistance connected between the check-request-input terminal and the check-result-output terminal. A DC impedance of an antenna between a power supplying point and a ground point is 0?, and when a high-level check-request signal is applied to the check-request-input terminal, in a case where the antenna is connected to an antenna-connection terminal, the switching element turns on, and in a case where the antenna is not connected to the antenna-connection terminal, the switching element turns off. Check-result signals that are output to the check-result-output terminal in these cases are different from each other.

Abstract: Systems and methods for measuring the integrity of insulation components in electrical systems. In preferred embodiments, an active sensor is coupled to a test tap of a bushing, the active sensor having an electrical circuit electrically coupled to the test tap, and wherein the electrical circuit includes a high pass filter that divides the electrical circuit into a high frequency bus and a power frequency bus. A grounded high frequency voltage is injected into the test tap via the frequency bus circuit. Resulting voltages and currents may be measured and compared to a reference voltage to determine capacitances and power factors for both the inner and outer sections of the bushing. Once the capacitances and power factors of the bushings are known, grounded and ungrounded high frequency voltages may be injected to determine capacitances and power factors of a connected transformer or reactor.

Abstract: Systems and methods are disclosed for on-line monitoring of the condition of insulation in electrical devices employing a differential current sensor. In certain embodiments a monitor that can be fitted to existing electrical devices by attachment of the sensor to a pair of phase cables is provided. In other embodiments, an electrical device configured with an insulation monitor is provided.

Abstract: A method for measuring the efficiency of an optical element is disclosed.

Abstract: In accordance with an embodiment of the present invention, a method of testing a plurality of semiconductor devices includes applying a stress voltage having a peak voltage on a shield line disposed over a substrate. The substrate has functional circuitry of a semiconductor device. A fixed voltage is applied to a first metal line disposed above the substrate adjacent the shield line. The first metal line is coupled to the functional circuitry and is configured to be coupled to a high voltage node during operation. The peak voltage is greater than a maximum fixed voltage. The shield line separates the first metal line from an adjacent second metal line configured to be coupled to a low voltage node during operation. The method further includes measuring a current through the shield line in response to the stress voltage, determining the current through the shield line of the semiconductor device, and based on the determination, identifying the semiconductor device as passing the test.

Abstract: A radio frequency front end testing method and a radio frequency front end testing device are provided in the present disclosure. The radio frequency front end testing device includes a processing module, a first multiplexing module and a second multiplexing module. The radio frequency front end testing method includes the steps of: transmitting a radio frequency front end testing control signal; switching a plurality of output channel terminals of the first multiplexing module and the second multiplexing module, and providing a testing data signal and a radio frequency front end testing clock signal to a plurality of devices under test; and executing a test procedure on the devices under test based on the testing data signal and the radio frequency front end testing clock signal.

Abstract: Many systems implement calibration schemes to measure and correct for the non-idealities. Such systems can be complex, which makes them impractical to implement since the cost can potentially outweigh the benefits of the calibration scheme. To implement efficient and effective calibration, non-idealities or errors of a system are detected, in foreground or in background, in a piecewise fashion based on, e.g., correlations of an output signal with an uncorrelated random signal, where the correlation results are processed separately for different open intervals of an error signal. Second order and third order correction terms can be easily determined based on three open intervals. In various embodiments, the calibration scheme can detect and correct for linear errors, (linear and non-linear) memory/frequency dependent errors, static nonlinearity errors, Hammerstein-style non-linearity errors, and Wiener-style non-linearity errors (cross-terms).

Abstract: A burn-in test process is omitted for some or all lots. In burn-in necessity determination processing, whether each semiconductor chip requires a burn-in test to be performed is determined based on measurement data obtained in a probe test process. In an assembly process, based on the results of determination made in the burn-in necessity determination processing, the assembled packages are sorted into a first lot which includes packages each including a semiconductor chip determined to require a burn-in test to be performed and a second lot which includes packages each including a semiconductor chip determined to require no burn-in test to be performed. In a burn-in test process, only the packages of the first lot are subjected to a burn-in test.

Abstract: This invention enhances reliability of an electrical test. A semiconductor device manufacturing method in which a potential (first potential) is supplied by bringing a plurality of first and second test terminals into contact with a plurality of leads, respectively in the step of supplying the potential to the leads (first leads) to carry out the electrical test. The first test terminals come into contact with the leads, individually, and the second test terminals come into contact with the leads in one batch.

Abstract: An apparatus for performing a scan test of IC chip includes a shift-frequency searching unit that executes first scan test for first scan pattern whole or part of which constituting first scan section and second scan test for second scan pattern whole or part of which constituting second scan section, and searches usable shift frequency for the second scan section. The first scan pattern is scan pattern inputted to scan path right before the second scan pattern. The shift-frequency searching unit shifts the first scan section to the scan path with first shift frequency in the first scan test, shifts the second scan section to the scan path with second shift frequency in the second scan test, and determines, when both results of the first scan test and the second scan test indicate pass, the second shift frequency as the usable shift frequency for the second scan section.

Abstract: A reception circuit receives, via a cable, a transmission signal STX generated by a DUT. A comparator circuit compares a reception signal SRX after signal transmission with at least one threshold signal VTH, and generates a judgment value DOUT that represents a comparison result for every sampling timing. A threshold generation circuit generates at least one threshold signal VTH. A threshold control circuit adjusts each level of at least one threshold signal VTH at a given sampling timing based on the history of the judgment value DOUT acquired at a past sampling timing.

Abstract: A test device for testing a device under test (DUT) includes an integrated control interface adaptable for a plurality of different communication standards. The integrated control interface can be adapted to be compliant with the communication standard used by a DUT connected to the test device.

Abstract: A method of determining a fault condition in a synchronous machine. The method includes a) obtaining a field current signal and a shaft voltage signal of the synchronous machine, b) transforming the field current signal and the shaft voltage signal to obtain a field current frequency spectrum and a shaft voltage frequency spectrum, and c) determining whether a fault condition is present, and in case a fault condition is present identifying a type of the fault condition, based on harmonic content of the field current frequency spectrum and harmonic content of the shaft voltage frequency spectrum, wherein c) includes comparing the harmonic content of the field current frequency spectrum with fault condition field current signature spectra and comparing the harmonic content of the shaft voltage frequency spectrum with fault condition shaft voltage signature spectra.