Patents Issued in April 26, 2018
  • 3-ARYL-2H-PYRAZOLO[4,3-b]PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111925
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Brian Ngo Laforteza, Brad M. Savall, Warren Stanfield Wade, Stephen Todd Meyer, Márió Gyuris
  • NEW PYRIDOPYRIMIDINES DERIVATIVES COMPOUNDS
    Publication number: 20180111926
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Application
    Filed: September 11, 2015
    Publication date: April 26, 2018
    Inventor: Gilberto De Nucci
  • HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20180111927
    Abstract: The present invention relates to heterocyclic-imidazole derivatives, a preparation method therefor, and a medical use thereof, and particularly to new heterocyclic-imidazole derivatives as represented by general formula (I), a preparation method therefor, pharmaceutical compositions comprising same, and a use thereof as a therapeutic agent, particularly as a poly(ADP-ribose)polymerase (PARP) inhibitor.
    Type: Application
    Filed: April 15, 2016
    Publication date: April 26, 2018
    Inventors: Xing FAN, Jihong QIN
  • PHARMACEUTICAL SALT FORMS OF AN INHIBITOR OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO)
    Publication number: 20180111928
    Abstract: The mesylate and sulphate salts of (3S)-Tetrahydrofuran-3-yl (4S)-4-isopropyl-,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate mesylate, and hydrates thereof, and their use in medicine.
    Type: Application
    Filed: April 22, 2016
    Publication date: April 26, 2018
    Applicant: PROXIMAGEN LIMITED
    Inventors: Edward SAVORY, Michael HIGGINBOTTOM
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20180111929
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: May 25, 2017
    Publication date: April 26, 2018
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOSITIONS AND USES THEREOF
    Publication number: 20180111930
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Application
    Filed: May 26, 2017
    Publication date: April 26, 2018
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephen Lauper, Johannes Pudewell, Frank Wierschem
  • CHEMICAL COMPOUNDS
    Publication number: 20180111931
    Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.
    Type: Application
    Filed: October 13, 2017
    Publication date: April 26, 2018
    Inventors: Bernard Christophe BARLAAM, Daniel Hillebrand O'DONOVAN, Samantha Jayne HUGHES, Thomas Andrew MOSS, Johannes Wilhelmus Maria NISSINK, James Stewart SCOTT, Bin YANG
  • NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA
    Publication number: 20180111932
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 26, 2018
    Inventors: Guillaume BARBE, Gregory Raymond BEBERNITZ, Sicong GENG, Hatice Belgin GULGEZE EFTHYMIOU, Lv LIAO, Fupeng MA, Ruowei MO, David Thomas PARKER, Yunshan PENG, Stefan PEUKERT, Ken YAMADA, Kayo YASOSHIMA
  • FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111933
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Márió Gyuris, Brian Ngo Laforteza, Terry Patrick Lebold, Stephen Todd Meyer, Suchitra Ravula, Brad M. Savall, Brock T. Shireman, Warren Stanfield Wade, János Gerencsér
  • HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF
    Publication number: 20180111934
    Abstract: The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and Z are defined as set forth in the specification. In certain embodiments, the invention is also directed to compounds of Formula II-VII and the pharmaceutically acceptable salts and solvates thereof. The invention is also directed to use of compounds of Formula I to VII, and the pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the invention are especially useful for treating pain.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 26, 2018
    Inventors: Laykea Tafesse, Mark A. Youngman
  • SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20180111935
    Abstract: The present invention relates to spiro-isoquinoline-1,4?-piperidine compounds having dual pharmacological activity towards both the sigma (?) receptor and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 20, 2015
    Publication date: April 26, 2018
    Inventors: Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ, Ana-Maria CAAMANO-MOURE
  • SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS
    Publication number: 20180111936
    Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
    Type: Application
    Filed: March 17, 2016
    Publication date: April 26, 2018
    Inventors: Hai-Yun XIAO, Murali T.G. DHAR, Jingwu DUAN, Bin JIANG, Andrew J. TEBBEN
  • TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF
    Publication number: 20180111937
    Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: —(CR3R3)2-5-, —(CR3R3)x-Y—(CR3R3)y-, —Y—(CR3R3)2-3-Y—, —CR3R3-Y—(CR3R3)2-Y—, —Y—(CR3R3)2-Y—CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
    Type: Application
    Filed: March 17, 2016
    Publication date: April 26, 2018
    Inventors: Stephen T. WROBLESKI, Gregory D. BROWN, Shuqun LIN, Jingwu DUAN, Zhonghui LU, Murali T.G. DHAR, Hai-Yun XIAO, Andrew J. TEBBEN
  • Synthesis of Intermediates Used in the Manufacture of Anti-HIV Agents
    Publication number: 20180111938
    Abstract: The present invention relates to a process of preparing intermediates of Formula (I). The process comprises of reacting compound of Formula (III) with compound of Formula (V) in the presence of a solvent selected from an alcohol, ether or water to form compound of Formula (I) wherein, R1 is selected from —NH2, Cl, Br, NHCOR?, wherein R? is alkyl, aryl, Schiff's base of formula N?CHR?, wherein R? is alkyl or aryl; R2 is selected from H, alkyl; R3 and R4, each independently is H; R5 and R6, each independently is H, alkyl; R7 is H, alkyl; and R8 is H, alkyl.
    Type: Application
    Filed: May 4, 2016
    Publication date: April 26, 2018
    Inventors: Braja Sundar PRADHAN, Kommireddy AMARNATH, Naresh VEMPALA, Md. Ataur RAHMAN
  • 7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFALMMATORY DISEASES OR CANCER
    Publication number: 20180111939
    Abstract: A compound of the general formula (I) wherein Y represents —CH2— or >C=0; R1 is selected from the group consisting of A1, A2 and A3; R2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R3 is selected from the group consisting of H, halogen, and C1-C4 alkyl; R4 is selected from the group consisting of C1-C4 alkyl, C3-C4-cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.
    Type: Application
    Filed: March 30, 2016
    Publication date: April 26, 2018
    Inventors: Barbara DYMEK, Marcin ZAGOZDA, Maciej WIECZOREK, Krzysztof DUBIEL, Aleksandra STANCZAK, Daria ZDZALIK, Pawel GUNERKA, Mariola SEKULAR, Maciej DZIACHAN
  • IMIDAZOPYRAZINE DERIVED COMPOUNDS FOR ELECTRONIC DEVICES
    Publication number: 20180111940
    Abstract: The invention provides a composition comprising at least one compound of Formula 1 through Formula 8, each as described herein. These compounds, containing an imidazopyrazine moiety, are useful in organic electroluminescence devices.
    Type: Application
    Filed: June 22, 2016
    Publication date: April 26, 2018
    Inventors: Mark E. Ondari, Dean M. Welsh, Robert DJ Froese, Hong-Yeop Na
  • BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
    Publication number: 20180111941
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Application
    Filed: September 27, 2017
    Publication date: April 26, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
    Publication number: 20180111942
    Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).
    Type: Application
    Filed: October 23, 2017
    Publication date: April 26, 2018
    Applicant: Janssen Pharmaceutica NV
    Inventors: Michael K. Ameriks, Brian Ngo Laforteza, Terry Patrick Lebold, Suchitra Ravula, Brad M. Savall, Brock T. Shireman
  • NOVEL N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS
    Publication number: 20180111943
    Abstract: A method for treating and/or preventing polycystic ovary syndrome (PCOS) including the administration, to a patient in need thereof, of a pharmaceutically effective amount of a compound of Formula I or a pharmaceutically acceptable solvate thereof.
    Type: Application
    Filed: October 27, 2017
    Publication date: April 26, 2018
    Inventors: Hamid HOVEYDA, Guillaume DUTHEUIL, Graeme FRASER
  • (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
    Publication number: 20180111944
    Abstract: (R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and prevention of pain.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 26, 2018
    Applicant: Tecnimede Sociedade Tecnico-Medicinal S.A.
    Inventors: Augusto Eugénio Pardal Filipe, Pedro Filipe Eufrásio Pedroso, Susana Marques Almeida Pecorelli, Carlos Alberto Eufrásio Casimiro Caixado, Ana Sofia da Conceição Lopes, João Carlos Ramos Damil
  • Chlorin e6 Derivative and Pharmaceutically Acceptable Salt Thereof and Process for Preparing and Use of the Same
    Publication number: 20180111945
    Abstract: Chlorin e6 derivatives and pharmaceutically acceptable salt thereof, as well as preparation and use thereof, which belongs to the medicine field. The chlorin e6 ether amino acid derivative has general structural formula I and optical isomers thereof. The preparation process has etherification of 3-vinyl in chlorin e6, A peptide is produced from 15-carboxylethyl and amino acid. The chlorin e6 ether amino acid derivative and pharmaceutically acceptable salt thereof can be used as a photodynamic anti-tumor drug. Compared with the prior similar photosensitizer Talaporfin used in clinic, the chlorin e6 ether amino acid derivative of the present application possess improved photodynamic anti-tumor activities and a high ratio of darktoxicity-phototoxicity.
    Type: Application
    Filed: May 25, 2017
    Publication date: April 26, 2018
    Inventor: Hui LIU
  • PROCESS FOR IMPROVED OPIOID SYNTHESIS
    Publication number: 20180111946
    Abstract: Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
    Type: Application
    Filed: September 11, 2017
    Publication date: April 26, 2018
    Applicant: RHODES TECHNOLOGIES
    Inventors: Stuart James GEBBIE, Joshua R. Giguere, Keith McCarthy, Lonn S. Rider
  • Method for Producing Levoglucosenone
    Publication number: 20180111947
    Abstract: There is described a method of producing (?)-levoglucosenone, said method comprising, heating lignin to a temperature in excess of 150° C. for a time sufficient to convert a proportion of the lignin to (?)-evoglucosenone.
    Type: Application
    Filed: April 20, 2016
    Publication date: April 26, 2018
    Applicant: University of York
    Inventors: James Hanley Clark, Mario De Bruyn, Vitaliy Lvovich Budarin
  • HERBICIDAL COMPOUNDS
    Publication number: 20180111948
    Abstract: The present invention relates to herbicidal benzyloxy-substituted phenyl diones and benzyloxy-substituted phenyl-di-oxo-thiazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants.
    Type: Application
    Filed: April 27, 2016
    Publication date: April 26, 2018
    Applicant: Syngenta Participations AG
    Inventors: Stephen Edward SHANAHAN, Timothy Jeremiah Cornelius O'RIORDAN
  • NOVEL INDUSTRIAL CRYSTALLIZATION METHOD OF CEFUROXIME SODIUM AND PREPARATION THEREOF
    Publication number: 20180111949
    Abstract: It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.
    Type: Application
    Filed: August 25, 2017
    Publication date: April 26, 2018
    Applicants: HAINAN LINGKANG PHARMACEUTICAL CO., LTD, TIANJIN UNIVERSITY
    Inventors: Linggang TAO, Hongxun HAO, Jingkang WANG
  • SUBSTITUTED AMINO SIX-MEMBERED SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS
    Publication number: 20180111950
    Abstract: The present application relates to a substituted amino six-membered saturated heteroalicycle represented by formula I as a long-acting DPP-IV inhibitor, a method for preparing the same, a pharmaceutical composition comprising the same, and a use of the same in treating and/or preventing diseases and disorders benefitting from DPP-IV inhibition.
    Type: Application
    Filed: February 4, 2016
    Publication date: April 26, 2018
    Inventors: Xinhe XU, Yu SHEN, Dengming XIAO, Hong LUO, Yong PENG, Yongxin HAN, Aiming ZHANG, Ling YANG
  • ANTICANCER ACTIVITY OF GOLD(III) COMPLEXES OF MESO-1,2-DI(1-NAPHTHYL)-1,2-DIAMINOETHANE
    Publication number: 20180111951
    Abstract: A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl2]Cl.2H2O (1) or [Au(npen)2]Cl3 (2); the complexes, and methods for making them.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 26, 2018
    Applicant: King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein A. ISAB, Muhammad ALTAF
  • COMPOUND AND ORGANIC PHOTOELECTRONIC DEVICE AND IMAGE SENSOR
    Publication number: 20180111952
    Abstract: A compound may be represented by Chemical Formula 1, an organic photoelectronic device may include a first electrode and a second electrode facing each other with an active layer that includes the compound represented by Chemical Formula 1 between the first electrode and the second electrode, and an image sensor may include the organic photoelectronic device.
    Type: Application
    Filed: December 21, 2017
    Publication date: April 26, 2018
    Applicant: Samsung Electronics Co., Ltd.
    Inventors: Moon Gyu Han, Seon-Jeong Lim, Takkyun Ro, Kwang Hee Lee, Dong-Seok Leem, Yong Wan Jin, Kyung Bae Park, Sung Young Yun, Gae Hwang Lee, Chul Joon Heo
  • METHOD FOR SYNTHESIS OF MONOCYCLOPENTADIENYL COMPLEXES OF ZIRCONIUM AND HAFNIUM
    Publication number: 20180111953
    Abstract: Catalyst systems and methods for making and using the same are disclosed. In an example, a method of synthesizing a monocyclopentadienyl compound is provided. The method includes melting a dicyclopentadienyl compound including the following structure: (A). As used herein, M is hafnium or zirconium. Each R is independently an H, a hydrocarbyl group, a substituted hydrocarbyl group, a heteroatom group. Each X is a leaving group selected from a halogen or a heteroatom group. A reaction melt is formed by adding a metal salt including the following structure: (B). A monocyclopentadienyl compound is deposited from a vapor formed over the reaction melt, wherein the monocyclopentadienyl compound includes the following structure: (C).
    Type: Application
    Filed: April 14, 2016
    Publication date: April 26, 2018
    Applicant: Univation Technologies, LLC
    Inventor: C. Jeff Harlan
  • PROCESS FOR MAKING PHOSPHORAMIDATE PROTECTED NUCLEOSIDE COMPOUNDS
    Publication number: 20180111954
    Abstract: The present invention is directed to process for making Compounds of Formula (II): (II), and salts thereof, wherein B, X, R2, R3, R4 R7, R8 and R9 are defined herein.
    Type: Application
    Filed: March 28, 2016
    Publication date: April 26, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Steven M. Silverman, Bryon Ladd Simmons, Zhuqing Liu, Jing Liao, Artis Klapars, Kevin R. Campos, Ana Inés Bellomo Peraza
  • THIOSACCHARIDE MUCOLYTIC AGENTS
    Publication number: 20180111955
    Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
    Type: Application
    Filed: November 27, 2017
    Publication date: April 26, 2018
    Inventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
  • SYNTHESIS OF DESOSAMINES
    Publication number: 20180111956
    Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A?) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D?) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.
    Type: Application
    Filed: March 25, 2016
    Publication date: April 26, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Ziyang Zhang
  • POLYMETHINE COMPOUNDS WITH LONG STOKES SHIFTS AND THEIR USE AS FLUORESCENT LABELS
    Publication number: 20180111957
    Abstract: The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. The labels are advantageous due to their long Stokes shifts.
    Type: Application
    Filed: May 23, 2016
    Publication date: April 26, 2018
    Inventors: Nikolai Romanov, Xiaolin Wu
  • METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS
    Publication number: 20180111958
    Abstract: Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
    Type: Application
    Filed: May 30, 2017
    Publication date: April 26, 2018
    Inventors: Takeshi Wada, Mamoru Shimizu
  • COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS
    Publication number: 20180111959
    Abstract: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.
    Type: Application
    Filed: May 8, 2017
    Publication date: April 26, 2018
    Applicant: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Chao-Chi Pan, Jenn-Yeh Fann, Shang-Chia Chang, Tsu-Ju Fu
  • METHODS FOR PREPARING DEOXYCHOLIC ACID
    Publication number: 20180111960
    Abstract: The present invention discloses method for preparing deoxycholic acid (DCA) or an ester thereof or a pharmaceutically acceptable salt thereof. Said compounds may be applied to remove a fat deposition.
    Type: Application
    Filed: February 26, 2016
    Publication date: April 26, 2018
    Applicant: NORATECH PHARMACEUTICALS, INC.
    Inventors: Cheng-Gang LIN, Li GUI, Pan CHEN, Zhi-Xuan WANG, Tong-Wei GUAN, Yuan-Yuan YIN, Yu-Ling LU
  • Purification method for divalent cation binding proteins by anion exchange chromatography
    Publication number: 20180111961
    Abstract: The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.
    Type: Application
    Filed: June 6, 2017
    Publication date: April 26, 2018
    Inventors: Artur Mitterer, Meinhard Hasslacher, Christian Fiedler
  • CALCIUM BINDING COMPOUNDS BASED ON GAMMA-CARBOXY GLUTAMATE
    Publication number: 20180111962
    Abstract: Compounds capable of binding calcium ions comprising a certain number of gamma-carboxy glutamate units have been found useful in treating and/or preventing mucus accumulation and stagnation in the respiratory tract. Pharmaceutical compositions comprising such compounds are disclosed. Such compounds and pharmaceutical compositions may be used for treatment of disorders of the respiratory tract.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 26, 2018
    Inventor: Gunnar C. Hansson
  • ANTI-MICROBIAL SUPRAMOLECULAR STRUCTURES
    Publication number: 20180111963
    Abstract: Supramolecular structures comprising noncovalently associated peptide amphiphiles and lipids are provided. In particular, provided herein are supramolecular nanostructures of peptide amphiphiles and lipids, co-assembly of which is driven by anion-n interactions, and methods of preparation and use (e.g., as an antimicrobial agent) thereof.
    Type: Application
    Filed: October 20, 2017
    Publication date: April 26, 2018
    Inventors: Samuel I. Stupp, Zhilin Yu, Nam-Joon Cho, Joshua A. Jackman
  • Fusion polypeptide for immuno-enhancement and method for enhancing stimulation of immune response using the same
    Publication number: 20180111964
    Abstract: A fusion polypeptide is disclosed, which includes: (a) a mucosa targeting polypeptide; (b) a translocating peptide for translocation; and (c) a antigenic epitope. In addition, a method for enhancing a stimulation of an immune response using the aforementioned fusion polypeptide is also disclosed.
    Type: Application
    Filed: October 26, 2017
    Publication date: April 26, 2018
    Inventors: Chao-Wei LIAO, Chung-Chin CHEN
  • CAPSID
    Publication number: 20180111965
    Abstract: There is described an AAV capsid protein having an amino acid sequence which has at least 98% identity to the sequence of SEQ ID NO: 3 or at least 94% identity to the sequence of SEQ ID NO: 4. Also described is a pharmaceutical composition, an AAV capsid and a viral particle comprising the capsid protein, a recombinant AAV vector comprising a nucleotide sequence which encodes for the capsid protein, and a host cell and a transgenic animal comprising the capsid protein or the vector. In addition, there is described a method of transferring a nucleic acid of interest into a mammal comprising introducing a recombinant AAV vector into the mammal, wherein the recombinant AAV vector comprises a gene of interest which is encapsidated into a capsid comprising the capsid protein.
    Type: Application
    Filed: May 10, 2016
    Publication date: April 26, 2018
    Inventors: Amit Nathwani, Allison Dane
  • PR13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES
    Publication number: 20180111966
    Abstract: The invention encompasses recombinant poxviruses, preferably modified Vaccinia Ankara (MVA) viruses, comprising a Pr13.5 promoter operably linked to a nucleotide sequence encoding an antigen and uses thereof. The invention is drawn to compositions and methods for the induction of strong CD8 T cell and antibody responses to a specific antigen(s) by administering one or more immunizations of the recombinant MVA to a mammal, preferably a human.
    Type: Application
    Filed: November 22, 2017
    Publication date: April 26, 2018
    Applicant: Bavarian Nordic A/S
    Inventors: Robin Steigerwald, Kay Brinkmann
  • STRUCTURE BASED METHODS FOR MODIFICATION OF PIP-72 POLYPEPTIDES AND PIP-72 POLYPEPTIDES DERIVED THEREFROM
    Publication number: 20180111967
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: April 26, 2018
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: LU LIU, JARRED KENNETH ORAL, BRAD POLAND, UTE SCHELLENBERGER
  • CELL-DIRECTED SYNTHESIS OF MULTIFUNCTIONAL NANOPATTERNS AND NANOMATERIALS
    Publication number: 20180111968
    Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
    Type: Application
    Filed: February 17, 2017
    Publication date: April 26, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Allen Yuyin Chen
  • A NUCLEIC ACID MOLECULE FOR CONFERRING INSECTICIDAL PROPERTIES IN PLANTS
    Publication number: 20180111969
    Abstract: The present invention is drawn to a nucleic acid sequence which confers expression of the insecticidal proteins mCry3A and eCry3.1Ab when introduced into a cell.
    Type: Application
    Filed: April 27, 2016
    Publication date: April 26, 2018
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Volker Mittendorf, Jared Conville, John Daniel Hipskind, Kasimalai Azhakanandam, Andrew Noe, Xiaoyin Fei, Kevin V. Donohue
  • LONG UNIFORM RECOMBINANT PROTEIN FIBERS
    Publication number: 20180111970
    Abstract: The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
    Type: Application
    Filed: September 14, 2017
    Publication date: April 26, 2018
    Inventors: David Breslauer, Joshua Kittleson, Loren Perelman, Lindsay Wray
  • CYCLIC, AMYLOID BETA-BINDING PEPTIDES AND THE USE THEREOF.
    Publication number: 20180111971
    Abstract: A peptide comprising at least one peptide binding to an amyloid beta species, wherein the peptide includes an amino acid sequence that is present in cyclized form. The use of the peptides in medicine, in particular for treating Alzheimer's disease, is disclosed.
    Type: Application
    Filed: September 23, 2014
    Publication date: April 26, 2018
    Inventors: Dieter WILLBOLD, Oleksandr BRENER
  • HYBRID CHIMERA POLYPEPTIDES AS DUAL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND PLATELET-DERIVED GROWTH FACTOR RECEPTOR
    Publication number: 20180111972
    Abstract: Polypeptides comprising hybrid VEGF and PDGF sequences are provided. The polypeptides are useful in inhibition of angiogenesis and treatment of diseases characterized by pathologic neovascularization.
    Type: Application
    Filed: January 15, 2016
    Publication date: April 26, 2018
    Inventors: Jennifer R. Cochran, Cheuk Lun Leung, Shiven Kapur, Mark S. Blumenkranz
  • PURIFICATION OF BONE MORPHOGENETIC PROTEINS (BMPS)
    Publication number: 20180111973
    Abstract: The present invention relates to a method for purifying a protein belonging to the transforming growth factor-? (TGF-?) superfamily, said method comprising subjecting a cell culture medium containing the protein to a Hydrophobic Charge 5 Interaction Chromatography (HCIC).
    Type: Application
    Filed: March 16, 2016
    Publication date: April 26, 2018
    Applicant: ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.P.A.
    Inventors: Fabio CENTOLA, Leonardo SIBILIO
  • METHODS OF PRODUCING LONG ACTING CTP-MODIFIED GROWTH HORMONE POLYPEPTIDES
    Publication number: 20180111974
    Abstract: Disclosed herein is a method for manufacturing a recombinant human growth hormone (h GH) modified by a CTP extension in a mammalian cells culture system.
    Type: Application
    Filed: December 10, 2015
    Publication date: April 26, 2018
    Inventors: Oren HERSHKOVITZ, Laura MOSCHCOVICH