Patents Issued in May 1, 2018
  • Process for the preparation of 2,3,3,3-tetrafluoropropene
    Patent number: 9957210
    Abstract: The invention provides a process for the preparation of 1234yf comprising (a) contacting 1,1,2,3,3,3-hexafluoropropene (1216) with hydrogen in the presence of a hydrogenation catalyst to produce 1,1,2,3,3,3-hexafluoropropane (236ea); (b) dehydrofluorinating 236ea to produce 1,2,3,3,3-pentafluoropropene (1225ye); (c) contacting 1225ye with hydrogen in the presence of a hydrogenation catalyst to produce 1,2,3,3,3-pentafluoropropane (245eb); and (d) dehydrofluorinating 245eb to produce 1234yf.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: May 1, 2018
    Assignee: MEXICHEM AMANCO HOLDINGS S.A. DE C.V.
    Inventors: John W. Smith, Claire McGuinness, Andrew P. Sharratt, Andrew M. Taylor
  • Methods and systems for separating C4 crude streams
    Patent number: 9957211
    Abstract: The present invention provides, among other things, new processes for separating and purifying C4 fractions from a crude C4 stream. Compared to prior methods, the processes of the present invention simplify the C4 separation processes, afford more possible configurations for separation and purification, and are more cost effective. The processes and systems provided herein can be used as part of a cost-effective and efficient method for synthesizing methyl tertiary-butyl ether.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: May 1, 2018
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Guillermo Leal, Zeeshan Nawaz, Renaat Hennus, Antonio Matarredona, Faisal Baksh
  • Process for producing 2,5-dihalophenolethers
    Patent number: 9957212
    Abstract: The present invention relates to a process for providing a compound of formula (IV): wherein R1 and R2 are each independently C1-C4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R1 and Hal is defined as above, to obtain a compound of formula (III) wherein R1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: May 1, 2018
    Assignee: BASF SE
    Inventors: Eric George Klauber, Michael Rack, Thomas Zierke, Nicole Holub, Gerald Schmelebeck, Junmin Ji, David Cortes
  • Organic compound, liquid crystal composition, liquid crystal element, and liquid crystal display device
    Patent number: 9957213
    Abstract: A novel organic compound that can be used in a variety of liquid crystal devices or a liquid crystal composition containing the novel organic compound is provided. An organic compound represented by General Formula (G1) is provided. A novel liquid crystal composition containing the organic compound is provided. In General Formula (G1), Ar1 and Ar2 separately represent a substituted or unsubstituted arylene group having 6 to 12 carbon atoms, a substituted or unsubstituted cycloalkylene group having 3 to 12 carbon atoms, or a substituted or unsubstituted cycloalkenylene group having 3 to 12 carbon atoms. In addition, m and n separately represent 0 or 1. R1 and R2 separately represent a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 11 carbon atoms, or a substituted or unsubstituted alkoxy group having 1 to 11 carbon atoms.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: May 1, 2018
    Assignee: SEMICONDUCTOR ENERGY LABORATORY CO.
    Inventors: Momoko Kato, Yasuhiro Niikura, Makoto Ikenaga, Manabu Kobayashi, Tetsuji Ishitani
  • Multifunctional radical quenchers
    Patent number: 9957214
    Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: May 1, 2018
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Manikandadas Mathilakathu Madathil, Omar Khdour, Sidney Hecht
  • Plant extract compositions for forming protective coatings
    Patent number: 9957215
    Abstract: Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: May 1, 2018
    Assignee: aPEEL Technology, Inc.
    Inventors: Louis Perez, Camille Mol, Ronald C. Bakus, II, James Rogers, Gabriel Rodriguez
  • Processes for producing acetic acid
    Patent number: 9957216
    Abstract: Process for producing acetic acid are disclosed in which a vapor sidedraw is withdrawn from the second column in the primary purification train. The vapor sidedraw comprises acetic acid and lithium-containing compounds at a concentration of no more than 100 wppb. A bottoms stream that is enriched in lithium-containing compounds, such as lithium acetate, or lithium acetate dihydrate, is also withdrawn from the second column. Advantageously, the vapor sidedraw, or a condensed portion thereof, is directly fed to a metal-exchanged ion exchange resin having acid cation exchange sites to produce purified acetic acid. This prevents displacement of the metals in the ion exchange resin.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 1, 2018
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: Ronald D. Shaver, Yaw-Hwa Liu, Mark O. Scates
  • Conversion of alcohols to carboxylic acids using heterogeneous palladium-based catalysts
    Patent number: 9957217
    Abstract: Disclosed are methods for synthesizing an ester or a carboxylic acid from an organic alcohol. To form the ester one reacts, in the presence of oxygen gas, the alcohol with methanol or ethanol. This reaction occurs in the presence of a catalyst comprising palladium and a co-catalyst comprising bismuth, tellurium, lead, cerium, titanium, zinc and/or niobium (most preferably at least bismuth and tellurium). Alternatively that catalyst can be used to generate an acid from that alcohol, when water is also added to the reaction mix.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 1, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shannon S. Stahl, Adam B. Powell, Thatcher W. Root, David S. Mannel, Maaz S. Ahmed
  • Isomerization of muconic acid
    Patent number: 9957218
    Abstract: Various embodiments disclosed relate to isomerization of muconic acid. In various embodiments, the present invention provides a method of forming trans,trans-muconic acid. The method includes heating a starting material composition to form a product composition including trans,trans-muconic acid. The starting material composition includes cis,cis-muconic acid, cis,trans-muconic acid, or a combination thereof. The starting material composition also includes an electrophilic compound, an organic solvent, or a combination thereof.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 1, 2018
    Assignee: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Jean-Philippe Tessonnier, Jack M. Carraher, Toni Pfennig, Brent Shanks
  • Antidiabetic bicyclic compounds
    Patent number: 9957219
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: May 1, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Thomas Bara, Harry R. Chobanian, Yan Guo, Hubert Josien, Michael Miller, Barbara Pio, Christopher W. Plummer, Cangming Yang, Dong Xiao
  • Treprostinil derivatives and compositions and uses thereof
    Patent number: 9957220
    Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: May 1, 2018
    Assignee: CORSAIR PHARMA, INC.
    Inventors: Xiaoming Zhang, Meenakshi S. Venkatraman, Cyrus K. Becker
  • Fruity odorant
    Patent number: 9957221
    Abstract: The present invention concerns the use as perfuming ingredient (of the fruity type) of a compound of formula (I) in the form of any one of its stereoisomers or of a mixture thereof, and wherein R1 represents a C1-3 alkyl or alkenyl group, R2 represents a methyl or ethyl group, R3 represents a C1-4 alkyl or alkenyl group, and said compound (I) has from 8 to 12 carbon atoms.
    Type: Grant
    Filed: May 25, 2009
    Date of Patent: May 1, 2018
    Assignee: Firmenich SA
    Inventors: Christian Vial, Roger Leslie Snowden
  • Organic oligomers of acylglycerol
    Patent number: 9957222
    Abstract: Organic oligomers of acylglycerol having general formula (I): Formula (I), in which M1 and Q1 are organic groups; G11 is a hydroxylpropyl group; G12 and G13 are ?/??-acylglycerols; n is a natural integer from the range [0; 8]; m is a natural integer from the range [0; 4]; and p is a natural integer from the range [0; 3].
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 1, 2018
    Assignees: Agronutrition, Institut National Polytechnique de Toulouse, Institut National de la Recherche Agronomique
    Inventors: Zephirin Mouloungui, Zaher Abdel Baki, Romain Valentin, Bachar Zebib
  • Bis(aryloxyalkyl) esters of aromatic polycarboxylic acids and method of preparation
    Patent number: 9957223
    Abstract: The invention provides a compound of the formula: wherein Ar is selected from the group consisting of aryl, monosubstituted aryl and polysubstituted aryl, heteroaryl, monosubstituted heteroaryl and polysubstituted heteroaryl; Ar? is selected from the group consisting of aryl, monosubstituted aryl and polysubstituted aryl, heteroaryl, monosubstituted heteroaryl and polysubstituted heteroaryl; R is an alkylene radical having 2-20 carbon atoms; and n=1-20. The compounds of the invention are used with polymer resins to enhance their gas barrier properties.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 1, 2018
    Assignee: ETHOX CHEMICALS LLC
    Inventor: James T Tanner
  • Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
    Patent number: 9957224
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: May 1, 2018
    Assignee: ACUCELA INC
    Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
  • Treatment of friedreich's ataxia using histone deacetylase inhibitors
    Patent number: 9957225
    Abstract: The invention provides methods of treating Friedreich's ataxia and other neurodegenerative or neuromuscular conditions using histone deacetylase inhibitors.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: May 1, 2018
    Assignee: The Scripps Research Institute
    Inventors: Joel M. Gottesfeld, Ann-Kristin Jenssen, David M. Herman, Ryan Burnett, C. James Chou
  • Antimicrobial compounds
    Patent number: 9957226
    Abstract: The invention provides compounds for use in treating microbial infection in an animal. Example compounds include Pyridin-3-ylmethyl (4-((2-aminophenyl)-carbamoyl)benzyl)carbamate (“Entinostat”). The compounds can act via induction of the innate antimicrobial peptide defense system, and stimulation of autophagy.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: May 1, 2018
    Assignee: Akthelia Pharmaceuticals
    Inventors: Roger Stromberg, Hakan Ottoson, Birgitta Agerberth, Gudmundur Gudmundsson, Erica Miraglia, Frank Nylen
  • Pharmaceutical formulations of HDAC inhibitors
    Patent number: 9957227
    Abstract: This invention pertains to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., which inhibit HDAC (histone deacetylase) activity) (e.g., PXD-101, N hydroxyl-3-(3-phenylsulfamoyl-phenyl)-acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine, and meglumine. The present invention also pertains to the use of such compositions, for example, in the inhibition of HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: May 1, 2018
    Assignee: TopoTarget UK Limited
    Inventors: Richard J. Bastin, Nicholas J. Hughes
  • Process of production of 7,8-dihydro-C15-aldehyde
    Patent number: 9957228
    Abstract: The present invention relates to a new method to produce 7,8-dihydro-C15-aldehyde.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 1, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jan Schuetz, Thomas Netscher, Bettina Wuestenberg
  • Amido compounds and their use as pharmaceuticals
    Patent number: 9957229
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: May 1, 2018
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Colin Zhang, Brian W. Metcalf, Chunhong He, Ding-Quan Qian
  • Synergistic compositions
    Patent number: 9957230
    Abstract: The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (1a) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of: these novel salts and use thereof.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: May 1, 2018
    Assignee: Cadila Healthcare Limited
    Inventors: Mukul R. Jain, Suresh Giri, Himanshu M. Kothari, Kaushik Banerjee, Rashmikant Kachhiya
  • Iodine(II)-mediated radiofluorination
    Patent number: 9957231
    Abstract: A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 1, 2018
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Benjamin H. Rotstein, Nickeisha A. Stephenson, Huan Liang
  • 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
    Patent number: 9957232
    Abstract: The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
    Type: Grant
    Filed: September 29, 2007
    Date of Patent: May 1, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Alfons Grunenberg, Juergen Stiehl, Katharina Tenbieg, Birgit Keil
  • Process for preparing substituted quinolin-4-ol compounds
    Patent number: 9957233
    Abstract: The invention relates to a process for preparing substituted quinolin-4-ol compounds useful for preparing protein tyrosine kinase (PTK) inhibitors which are useful in treating cancer.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: May 1, 2018
    Assignees: CALITOR SCIENCES, LLC, SUNSHIRE LAKE PHARMA CO., LTD.
    Inventor: Ning Xi
  • Polymorphs of Ivacaftor, process for its preparation and pharmaceutical composition thereof
    Patent number: 9957234
    Abstract: The present invention relates to novel polymorphic forms of ivacaftor, process for its preparation and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: May 1, 2018
    Assignee: Laurus Labs Limited
    Inventors: Ram Thaimattam, Venkata Srinivasa Rao Dama, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
  • Benzimidazol-2-amines as mIDH1 inhibitors
    Patent number: 9957235
    Abstract: The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: May 1, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Hartmut Rehwinkel, Olaf Panknin, Sven Ring, Sonja Anlauf, Holger Siebeneicher, Duy Nguyen, Wolfgang Schwede, Marcus Bauser, Katja Zimmermann, Stefan Kaulfuss, Roland Neuhaus, Paul Matthew Blaney
  • Selective inhibitors interfering with fibroblast growth factor receptor and FRS2 interaction for the prevention and treatment of cancer and other diseases
    Patent number: 9957236
    Abstract: The present technology relates to medicine and includes the use of inhibitors which selectively interfere with the interaction between a fibroblast growth factor receptor and FRS2, and with the interaction with other components of the FRS2 complex. Use of the selective inhibitors described in the present technology leads to a proven increase in anti-tumor efficacy relative to other inhibitors and monoclonal antibodies, a decrease in the toxicity of treatment, and the possibility of achieving complete blockage using a low agent concentration and of conducting long-term treatment. The advantage of the technology includes the development of a novel class of medicinal agents for treating malignant neoplasms and other diseases.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 1, 2018
    Assignee: LIMITED LIABILITY COMPANY “RUSSIAN PHARMACEUTICAL TECHNOLOGIES”
    Inventors: Sergey Alexeevich Tjulandin, Mikhail Yur'evich Byakhov, Ilya Valer'evich Tsimafeyeu
  • Crystal form of neptinib di-p-methylbenzenesulfonate, preparation method thereof, and pharmaceutical composition containing same
    Patent number: 9957237
    Abstract: Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide p-toluene sulfonate 1.5 hydrate ?-polymorph. The ?-polymorph has a stable form, a defined melting point, a good chemical stability, and a good endurance to high temperature and light irradiation, and is suitable for pharmaceutical use.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 1, 2018
    Assignee: SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.
    Inventors: Tian Tang, Feng Jin, Yanqing Wang, Jing Wu, Xiarou Liu, Jing'an Yang, Hanlin Feng, Lin Yu
  • Arylalkyl-and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
    Patent number: 9957238
    Abstract: The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: May 1, 2018
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Process and plant for the synthesis of urea and melamine
    Patent number: 9957239
    Abstract: An integrated process for the synthesis of urea and melamine, wherein: urea is synthesized with a stripping process in a high-pressure synthesis loop comprising a reactor, a stripper and a carbamate condenser, and the urea solution leaving said stripper is sent to a recovery section to produce a concentrated urea product and a recovered carbamate solution; at least part of said urea product is converted to melamine, and the off-gas from the synthesis of melamine are recycled to the urea synthesis by mixing with the gas phase from the stripper and with said recovered carbamate solution, thus forming a mixed flow which is then condensed in said carbamate condenser, and the condensate is eventually directed to the reactor.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 1, 2018
    Assignee: Casale SA
    Inventors: Paolo Bertini, Gabriele Di Carlo
  • Crystalline forms of trisodium supramolecular complex comprising valsartan and AHU-377 and methods thereof
    Patent number: 9957240
    Abstract: Novel crystalline Forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3?-methyl-T-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 1, 2018
    Assignees: CRYSTAL PHARMATECH CO., LTD, SUZHOU PENGXU PHARMATECH CO., LTD.
    Inventors: Minhua Chen, Yanfeng Zhang, Chaohui Yang, Xiaoyu Zhang, Jiaoyang Li, Peng Wang, Pixu Li
  • Aromatic diamine, an intermediate therefor, a method for producing the aromatic diamine, and a method for producing the intermediate therefor
    Patent number: 9957241
    Abstract: A novel asymmetric diamine, diamino-2-(benzothiazole-2-yl)diphenyl ether, derivatives therefor, and an intermediate for the compound such as aminonitro-2-(benzothiazole-2-yl)diphenyl ether, dinitro-2-(benzothiazole-2-yl)diphenyl ether, and derivatives from these. Additionally, another novel asymmetric diamine, diamino-2-(benzoxazole-2-yl)diphenyl ether, derivatives therefor, and intermediate for the compound such as aminonitro-2-(benzoxazole-2-yl)diphenyl ether, dinitro-2-(benzoxazole-2-yl)diphenyl ether, and derivatives from these, and methods for preparing them.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: May 1, 2018
    Assignee: SEIKA CORPORATION
    Inventors: Motonori Takeda, Masahiro Kasamatsu, Akihiro Tamaki, Seiichi Mori, Mitsutaka Imoto, Yoshihisa Takeda
  • Carbamate compounds and methods of making and using same
    Patent number: 9957242
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: May 1, 2018
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, ABIDE THERAPEUTICS, INC.
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M Lum, Benjamin F. Cravatt
  • Vinyl-containing compounds and processes for making the same
    Patent number: 9957243
    Abstract: The present invention provides a process for forming vinyl-containing compounds including the steps of: a) reacting in a nitrogen atmosphere a dicarboxylic acid and/or anhydride and a functional mono or polyfunctional alcohol to provide a hydroxyl-containing polyester; b) reacting the hydroxyl-containing polyester with a vinyl-containing organic acid in the presence of an esterification catalyst, a polymerization inhibitor and an azeotropic agent; and c) reacting the vinyl functional esterified intermediate, residual esterification catalyst and residual vinyl-containing organic acid with an epoxy to provide the vinyl-containing compound.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: May 1, 2018
    Assignee: Reichhold LLC 2
    Inventors: Hildeberto Nava, Yongning Liu
  • Catalyst and process for producing 2,5-furandicarboxylic acid from hydroxymethylfurfural in water
    Patent number: 9957244
    Abstract: A process is described for converting hydroxymethylfurfural to furanic products inclusive of 2,5-furandicarboxylic acid, comprising combining a quantity of hydroxymethylfurfural with water to provide an aqueous solution containing at least about five percent by weight of hydroxymethylfurfural, and combining the aqueous solution with an oxygen source in the presence of a heterogeneous ruthenium-based catalyst and under conditions which are effective for oxidizing hydroxymethylfurfural to furanic oxidation products inclusive of 2,5-furandicarboxylic acid, but in the substantial absence of any solvent for either hydroxymethylfurfural or 2,5-furandicarboxylic acid other than water.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: May 1, 2018
    Assignee: Archer Daniels Midland Company
    Inventor: Alexandra Sanborn
  • Catalyst for synthesizing theaflavins and method for synthesizing theaflavins
    Patent number: 9957245
    Abstract: The objective/problem addressed by the present invention is to provide a novel technique pertaining to theaflavins synthesis. The present invention pertains to: a theaflavins synthesis catalyst characterized in having a base comprising an inorganic material, and metal nanoparticles anchored to the base, said particles measuring 0.5-100 nm in diameter; and a theaflavins synthesis method in which the catalyst is used.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 1, 2018
    Assignee: NBC MESHTEC INC.
    Inventors: Yoshie Fujimori, Tsuruo Nakayama, Tomokazu Nagao
  • Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same
    Patent number: 9957246
    Abstract: Described herein are ?9-THC prodrugs, methods of making ?9-THC prodrugs, formulations comprising ?9-THC prodrugs and methods of using ?9-THC. One embodiment described herein relates to the transdermal administration of a ?9-THC prodrug for treating and preventing diseases and/or disorders.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: May 1, 2018
    Assignee: ZYNERBA PHARMACEUTICALS, INC.
    Inventors: Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammell, Jeffery Lynn Howard
  • SecA inhibitors and methods of making and using thereof
    Patent number: 9957247
    Abstract: Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: May 1, 2018
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Binghe Wang, Phang-Cheng Tai, Jinshan Jin, Yinghsin Hsieh, Ying-Ju Ritter, Jianmei Cui, Arpana S. Chaudhary, Chaofeng Dai, Krishna Damera, Weixuan Chen
  • Substituted 5-hydroxy-2-heteroaryl-3-phenylpentanonitrile derivatives, processes for their preparation and their use as herbicides and/or plant growth regulators
    Patent number: 9957248
    Abstract: Primarily, the present invention relates to compounds of the formula (I) defined below and to their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention also relates to herbicidal or plant growth-regulating compositions comprising one or more compounds of the formula (I). Moreover, the present invention relates to processes for preparing the compounds of the formula (I).
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: May 1, 2018
    Assignee: Bayer Cropscience Aktiengesellshaft
    Inventors: Marc Mosrin, Harald Jakobi, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Saturated nitrogen and N-acylated heterocycles potentiating the activity of an active antibiotic against
    Patent number: 9957249
    Abstract: The present invention concerns a compound of general formula (I): in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 1, 2018
    Assignee: UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
    Inventors: Nicolas Willand, Benoit Deprez, Alain Baulard, Priscille Brodin, Marion Flipo, Lucie Maingot
  • Compounds and uses thereof for the modulation of hemoglobin
    Patent number: 9957250
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 1, 2018
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Jason R. Harris, Zhe Li, Stephen L. Gwaltney, II
  • Heterocyclic compound
    Patent number: 9957251
    Abstract: The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 1, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Takaharu Hirayama, Jun Fujimoto, Douglas Robert Cary, Masanori Okaniwa, Yasuhiro Hirata
  • Metalloenzyme inhibitor compounds as fungicides
    Patent number: 9957252
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: May 1, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Triaminopyrimidine compounds useful for preventing or treating malaria
    Patent number: 9957253
    Abstract: The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and/or prevention of malaria caused by plasmodium species, and to their methods of preparation.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 1, 2018
    Assignee: MMV MEDICINES FOR MALARIA VENTURE
    Inventors: Shahul Hameed Peer Mohamed, Vikas Patil, Kannan Murugan, Eknath Vithalrao Bellale, Anandkumar Raichurkar, Sudhir Landge, Jayashree Puttur, Nilanjana Roy Choudhury, Gajanan Shanbhag, Krishna Koushik, Pravin Iyer, Vasan Kirthika Sambandamurthy, Suresh Solapure, Shridhar Narayanan
  • Cyclohexen-1-yl-pyridin-2-yl-1h-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators
    Patent number: 9957254
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: May 1, 2018
    Assignee: Novartis AG
    Inventors: Christopher M. Adams, David B. Belanger, Doug Bevan, Philippe Bolduc, Takeru Ehara, Luciana Ferrara, Nan Ji, Mitsunori Kato, Erik Meredith, Muneto Mogi, James J. Powers, Ganesh Prasanna
  • Benzotriazole derivatives as modulators of TNF activity
    Patent number: 9957255
    Abstract: A series of substituted benzotriazole derivatives, being potent modulators of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 1, 2018
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Daniel Christopher Brookings, Boris Kroeplien
  • Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
    Patent number: 9957256
    Abstract: A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) as described herein and further reactions with this compound.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: May 1, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Sergii Pazenok, Norbert Lui, Christian Funke
  • Amide compounds as 5-HT4 receptor agonists
    Patent number: 9957257
    Abstract: The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: May 1, 2018
    Assignee: SUVEN LIFE SCIENCES LIMITED
    Inventors: Ramakrishna Nirogi, Anil Karbhari Shinde, Abdul Rasheed Mohammed, Sangram Keshari Saraf, Narsimha Bogaraju, Ramkumar Subramanian, Pradeep Jayarajan, Gopinadh Bhyrapuneni, Venkateswarlu Jasti
  • Oxime ester photoinitiators
    Patent number: 9957258
    Abstract: Disclosed are oxime ester compounds which have specific benzo (unsaturated 5-membered ring)-carbonyl group and their use as photoinitiators in photopolymerizable compositions, in particular in photoresist formulations for display applications, e.g. liquid crystal display (LCD), organic light emitting diode (OLED) and touch panel.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: May 1, 2018
    Assignee: BASF SE
    Inventors: Kazuhiko Kunimoto, Hisatoshi Kura, Hiroshi Yamamoto, Yumiko Nakagawa, Toshikage Asakura, Kaori Sameshima
  • Selective HDAC1 and HDAC2 inhibitors
    Patent number: 9957259
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1 and/or HDAC2. Such diseases include cancer, sickle-cell anemia, beta-thalassemia, and HIV.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: May 1, 2018
    Assignee: REGENACY PHARMACEUTICALS, LLC
    Inventors: John H. van Duzer, Ralph Mazitschek