Patents Issued in May 1, 2018
  • Patent number: 9957461
    Abstract: A polyester composition, suitable for use as a dispersant in lubricating oils, is disclosed. The polyester composition is prepared by reacting (a) an acylating agent selected from an aliphatic-substituted succinic acylating agent, an aromatic polycarboxylic acylating agent, and combinations thereof; and (b) a hydroxyalkyl-substituted tertiary amine compound of the following structure: wherein R? is a C1-24 aliphatic group; R in each of the x (RO), y (RO) and z (RO) groups is independently C2-4 alkylene; x+y is in a range of 2 to 7; and z is in a range of 1 to 5.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: May 1, 2018
    Assignee: Chevron U.S.A. Inc.
    Inventor: William Raymond Ruhe, Jr.
  • Patent number: 9957462
    Abstract: The present disclosure concerns engine lubricant compositions including at least one base oil, at least one viscosity index improver polymer and at least one polyalkylene glycol, obtained by polymerization or copolymerization of alkylene oxides comprising from 3 to 8 carbon atoms, including at least one butylene oxide, the quantity of polyalkylene glycol being from 1 to 28% by mass with respect to the total mass of lubricant composition. Using at least one polyalkylene glycol, obtained by polymerization or copolymerization of alkylene oxides including from 3 to 8 carbon atoms, further including at least one butylene oxide in a base oil improves engine cleanliness while not increasing, or indeed while decreasing, the consumption of petrol or diesel fuels by the engine.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: May 1, 2018
    Assignees: Total Marketing Services, Dow Global Technologies LLC
    Inventors: Julien Guerin, Nicholas Obrecht, Nadjet Khelidj
  • Patent number: 9957463
    Abstract: A power transmitting fluid comprises a major amount of a lubricating oil and a minor amount of an additive composition. The additive composition comprises: (a) a friction modifier of the formula: (b) an oil-soluble phosphorus compound; and, (c) an ashless dispersant; wherein R1 and R2 may be the same or different and represent linear or branched, saturated or unsaturated hydrocarbyl groups having from 8 to 20 carbon atoms. Z represents a polyoxyalkylene segment or a polyalkoxylated alkyl amine segment. The friction modifiers provide the fluid with improved fluoroelastomer seal compatibility and enhanced copper corrosion compatibility.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 1, 2018
    Assignee: INFINEUM INTERNATIONAL LIMITED
    Inventors: Raymond F. Watts, Keith R. Gorda
  • Patent number: 9957464
    Abstract: Methods and devices for economically producing a purified biodiesel product from feedstocks. Some embodiments of the methods comprise using at least one of a crude feedstock pretreatment process and a free fatty acid refining process prior to transesterification and the formation of crude biodiesel and glycerin. The crude biodiesel is then subjected to at least one biodiesel refining process which, in conjunction with feedstock pretreatment and free fatty acid refining produces a purified biodiesel product that meets multiple commercial specifications. A wide variety of feedstocks may be used to make biodiesel that otherwise would not meet the same commercial specifications, including corn oil, used cooking oil, poultry fats, fatty acid distillates, pennycress oil, and algal oils.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: May 1, 2018
    Assignee: Renewable Energy Group, Inc.
    Inventors: David A Slade, Cody J Ellens, Bradley N Albin, Derek J Winkel, Jared A Downey
  • Patent number: 9957465
    Abstract: One or more techniques are disclosed for a process of preparing stearic acid from animal and/or plant sources may comprise: 1) deodorizing and distilling a fat; 2) concentrating fatty acids of the fat; and 3) hydrogenating the fatty acid to provide stearic acid. The process may include the use of co-products from plant and/or animal sources. The process may also include distilling the stearic acid to provide palmitic acid and/or fully hydrogenated fatty acid. Tallow fatty acid, vegetable fatty acid, stearic acid, and palmitic acid prepared from the process described are also disclosed.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: May 1, 2018
    Assignee: Magnus International Group, Inc.
    Inventor: Eric E. Lofquist
  • Patent number: 9957466
    Abstract: A solid free-flowing particulate laundry detergent composition including: (a) from 0.1 wt % to 5 wt % polymer particle comprising: (i) from 70 wt % to 90 wt % co-polymer and (ii) from 10 wt % to 30 wt % salt; and (b) from 35 wt % to 80 wt % spray-dried particle including: (i) from 8 wt % to 24 wt % alkyl benzene sulphonate anionic detersive surfactant; (ii) from 5 w % to 18 wt % silicate salt; (iii) from 0 wt % to 10 wt % sodium carbonate; and (iv) from 0 wt % to 5 wt % carboxylate polymer.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 1, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Hossam Hassan Tantawy, Adam Porter, Andre Chieffi, Jill Robyn Dorgan, Anthony McMeekin, Paul Anthony Gould
  • Patent number: 9957467
    Abstract: The need for a liquid hard surface cleaning composition which provides improved shine, reduced slipperiness during drying, and also improved drying times is met formulating the composition using a ethoxylated alkoxylated nonionic surfactant, in combination with a detersive surfactant.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: May 1, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Gloria Di Capua, Geert Andre Deleersnyder, Stefanos Kantaridis, Felicetta Landi, Stefano Scialla
  • Patent number: 9957468
    Abstract: Shaped particles having a longitudinal length (L) and a predetermined complex cross-sectional shape extending on a plane perpendicular to said longitudinal length (L). The cross-sectional shape has at least one vertex. An edge extends along the length L from the vertex. The particles further comprise an anchoring element disposed away from the edge. The ratio of said length (L) to a perimeter-equivalent diameter of said predetermined cross-sectional shape “ECD PHull” is between about 0.5 and about 5.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: May 1, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Denis Alfred Gonzales, Michael Leslie Groombridge, Michael McDonnell
  • Patent number: 9957469
    Abstract: There are provided metal corrosion inhibition cleaning compositions, methods and system for copper (Cu), tungsten (W), titanium (Ti), tantalum (Ta), cobalt (Co), and aluminum (Al). The metal corrosion inhibition cleaning compositions provide corrosion inhibition effects by use a combination of two chemicals—at least one multi-functional amine that has more than one amino groups; and at least one multi-functional acid that has more than one carboxylate groups. The metal corrosion inhibition cleaning compositions are effective for cleaning the residues deriving from high density plasma etching followed by ashing with oxygen containing plasmas; and slurry particles and residues remaining after chemical mechanical polishing (CMP).
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: May 1, 2018
    Assignee: VERSUM MATERIALS US, LLC
    Inventors: Wen Dar Liu, Seiji Inaoka, Yi-Chia Lee, Agnes Derecskei-Kovacs
  • Patent number: 9957470
    Abstract: A solid free-flowing particulate laundry detergent composition comprising: (a) from 0.1 wt % to 5 wt % hueing agent particle comprising: (i) from 2 wt % to 10 wt % hueing agent, wherein the hueing agent has the following structure: wherein: R1 and R2 are independently selected from H; alkyl; alkoxy; alkyleneoxy; alkyl capped alkyleneoxy; urea; and amido; R3 is a substituted aryl group; X is a substituted group comprising sulfonamide moiety; and (ii) from 60 wt % to 98 wt % clay; and (b) from 35 wt % to 80 wt % spray-dried particle comprising: (a) from 8 wt % to 24 wt % alkyl benzene sulphonate anionic detersive surfactant; (b) from 5w % to 18 wt % silicate salt; (c) from 0 wt % to 10 wt % sodium carbonate; and (d) from 0 wt % to 5 wt % carboxylate polymer.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 1, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Hossam Hassan Tantawy, Adam Porter, Andre Chieffi, Jill Robyn Dorgan, Anthony McMeekin, Paul Anthony Gould, William Alexander Caufield
  • Patent number: 9957471
    Abstract: Liquid laundry detergent compositions. Water-soluble unit dose articles that include a gel and a particle.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 1, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Mauro Vaccaro, Anju Deepali Massey Brooker, Nigel Patrick Somerville-Roberts, Alan Thomas Brooker, Eric San Jose Robles, Melissa Cuthbertson, Lynn Donlon
  • Patent number: 9957472
    Abstract: A microfluidic platform for single-cell capture, stimulation, and imaging. It passively traps 4,000 single cells on a 4.5 mm2 footprint in 30 seconds, with a single-cell loading efficiency of 95%. The array format and optimized geometry allows for easy, robust and efficient single-cell loading, while maintaining captured cells in a low shear stress environment for long-term studies. Because cells are captured sequentially, the system is adequate for rare cell samples. Trapped cells can be exposed to various environmental conditions and chemical stimulus and their dynamic response can be monitored over time. The information gained from high-throughput, single-cell time lapsed imaging presents new opportunities in quantifying cellular responses, as averaged information by other measurement methods eliminates sub-population phenotypes.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: May 1, 2018
    Assignee: Georgia Tech Research Corporation
    Inventors: Kwanghun Chung, Catherine Rivet, Hang Lu, Melissa Kemp
  • Patent number: 9957473
    Abstract: A device for preparing biological samples including a fixed support of which the base extends in a first plane, a filtration block that can be removable, the filtration block including a collecting tank that itself includes a filtering device extending in a second plane and dividing the collecting tank into a collection area and a suction area, the suction area being designed to be connected to a suction device, the second plane of the filtering device being inclined relative to the plane of the base of the fixed support.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 1, 2018
    Assignee: BIOMERIEUX
    Inventors: Patrick Broyer, Laurent Veron, Hervé Rostaing
  • Patent number: 9957474
    Abstract: A centrifuge layering insert configured for insertion into a centrifuge tube includes a tube having a first open end and a second open end. The centrifuge layering insert also includes a casing having an outer wall, an inner wall, a first open end, and a second substantially closed end. The casing forms an annular space around the tube between the tube first end and the tube second end. The tube has at least a portion of the length extending beyond the first open end of the casing in a direction opposite the second open end of the tube.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 1, 2018
    Assignee: Safely Art, LLC
    Inventor: Vera Johnson
  • Patent number: 9957475
    Abstract: Aspects of the present invention provide novel apparatus and methods for sampling microbial organisms present on surfaces. Preferred apparatus comprises: a reservoir suitable for providing microbial collection fluid; a sterilizable sample collection chamber; a sterilizable, integrated collection fluid delivery and collection fluid recovery member, suitable to deliver collection fluid to a target surface, and contemporaneously recover the delivered fluid from the surface; delivery means, in communication with both the reservoir and the integrated member, and operable to aseptically deliver collection fluid from the reservoir to the integrated member; and vacuum means, in communication with both the sample collection chamber and the integrated member, and operable to direct collection fluid, delivered and recovered by the integrated member, to the sample collection chamber.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: May 1, 2018
    Assignee: Institute for Environmental Health, Inc.
    Inventor: Mansour Samadpour
  • Patent number: 9957476
    Abstract: A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: May 1, 2018
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
    Inventors: Frank Gunn-Moore, Kishan Dholakia, Yoshihiko Arita
  • Patent number: 9957477
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 1, 2018
    Assignee: LifeCell Corporation
    Inventors: Yi Chen, Hui Xu, Li Ting Huang, Wenquan Sun, Hua Wan
  • Patent number: 9957478
    Abstract: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 1, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Brian Michael Davis, Evelina Roxana Loghin, Kenneth Roger Conway, Andrew Arthur Paul Burns, David Gilles Gascoyne
  • Patent number: 9957479
    Abstract: The invention relates to mammalian haploid embryonic stem cells and methods for the production of such stem cells. The inventions also relates to a cell culture and a cell line of mammalian haploid embryonic stem cells.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 1, 2018
    Inventors: Anton Wutz, Martin Leeb
  • Patent number: 9957480
    Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: May 1, 2018
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Charles L. Sentman
  • Patent number: 9957481
    Abstract: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: May 1, 2018
    Assignee: Academia Sinica
    Inventors: Keng-Hui Lin, Narayan Mishra, Yen-Liang Liu, Chen-Chie Wang
  • Patent number: 9957482
    Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: May 1, 2018
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Casey Stankewicz, Matt Riley, Nathaniel Beardsley, Wen Bo Wang, Peter Fuhrken, Steven Kattman
  • Patent number: 9957483
    Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: May 1, 2018
    Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
  • Patent number: 9957484
    Abstract: The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks involving such kinases are also identified that may be advantageously targeted to significantly increase reprogramming efficiency as well as direct differentiation of induced pluripotent stem (iPS) cells.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 1, 2018
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Tariq M. Rana
  • Patent number: 9957485
    Abstract: The present invention provides a closed system to propagate virus-infected cells without the effect of shear force, while providing quicker access to nutrients than is available conventionally. This system design allows for a high density of infected cell growth to increase the virus yields and to maintain homogeneity of the contents of the main container. The system further provides a nuclease to degrade the cellular DNA prior for purification of the virus or viral components. As the system is designed for maximum containment at low risk, the live virus can be a hazardous virus such as a Bio-safety Level 3 (BSL 3), BSL 4 or BSL5 virus.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: May 1, 2018
    Assignee: Inventprise, LLC
    Inventor: Subhash V. Kapre
  • Patent number: 9957486
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 1, 2018
    Assignees: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, The Research Foundation For the State University of New York
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • Patent number: 9957487
    Abstract: Luciferases which are different from those known heretofore have been desired. A luciferase mutant comprising an amino acid sequence in which at least one amino acid selected from the group consisting of valine at the position of 44, alanine at the position of 54 and tyrosine at the position of 138 is substituted with other amino acid(s) in the amino acid sequence of SEQ ID NO: 2.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 1, 2018
    Assignee: JNC CORPORATION
    Inventors: Satoshi Inouye, Junichi Sato
  • Patent number: 9957488
    Abstract: The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: May 1, 2018
    Assignee: INSITUT NATIONAL DES SCIENCES APPLIQUEES (INSA)
    Inventors: Sophie Anne Michèle Bozonnet, Magali Martine Claude Remaud-Simeon, René-Marc Lucien Willemot, Pierre Emmanuel Frédéric Monsan
  • Patent number: 9957489
    Abstract: The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: May 1, 2018
    Assignee: Shire Pharmaceuticals Ireland Limited
    Inventors: Jens Fogh, Claes Andersson, Cecilia Weigelt, Christer Moller, Pia Hyden
  • Patent number: 9957490
    Abstract: The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. Also, methods are disclosed for making and using the engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: May 1, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Paul Daniel Donohoue, Andrew Paul May
  • Patent number: 9957491
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 1, 2018
    Assignee: Novozymes, Inc.
    Inventors: Yu Zhang, Lan Tang, Svend Hostgaard Bang Henriksen
  • Patent number: 9957492
    Abstract: Provided are isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 1, 2018
    Assignee: Novozymes A/S
    Inventors: Lan Tang, Ye Liu, Yu Zhang
  • Patent number: 9957493
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: May 1, 2018
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Elena Vlasenko, Brett McBrayer, Mary Stringer, Kirk Schnorr
  • Patent number: 9957494
    Abstract: In some embodiments, the present invention provides method of identifying compounds that bind to phosphoinositol 4-phosphate adaptor protein-2 (FAPP2), including the steps of computationally identifying a compound that binds to FAPP2 using the atomic coordinates of at least the amino acids which make up the substrate binding pocket of FAPP2. Also provided are methods of designing, selecting and/or optimizing a compound that binds to FAPP2.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: May 1, 2018
    Assignees: SHIRE HUMAN GENETIC THERAPIES, INC., FONDAZIONE TELETHON
    Inventors: Muthuraman Meiyappan, Maria A. DeMatteis
  • Patent number: 9957495
    Abstract: The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to the wild-type protein.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: May 1, 2018
    Assignees: VIB VZW, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D
    Inventors: Frederic Rousseau, Joost Schymkowitz, Ashok Ganesan, Aleksandra Siekierska, Frederik De Smet, Joost Van Durme
  • Patent number: 9957496
    Abstract: Provided are a method for regulating acid resistance of a microorganism by suppressing the expression of the fadD gene therein and a screening method for a microorganism having acid resistance by using the expression level of the fadD gene as an index. A method for regulating acid resistance of a microorganism, including suppressing the expression of fadD gene present in the microorganism.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: May 1, 2018
    Assignee: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hoshitaka Matsumoto, Mika Miura, Mayumi Kiwaki, Tohru Iino
  • Patent number: 9957497
    Abstract: A hydrocarbon synthase gene encoding protein having excellent capacity to synthesize a hydrocarbon such as alkane and novel functions is provided. The gene encodes a protein comprising an amino acid sequence comprising a motif sequence shown in SEQ ID NO: 1 and having activity of synthesizing a hydrocarbon with a carbon number one less than that of an aldehyde compound from the aldehyde compound.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: May 1, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Masayoshi Muramatsu, Masakazu Ito
  • Patent number: 9957498
    Abstract: The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: May 1, 2018
    Assignee: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Arthur Henry Winter, Christie Lynn Beck, Kaitlyn Marie Mahoney, Toshia Renee Albright, Pratik Pran Goswami
  • Patent number: 9957499
    Abstract: The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising in vitro synthesized mRNA to a denaturing condition, and purifying the mRNA from the impure preparation from step (a) by tangential flow filtration, wherein the mRNA purified from step (b) is substantially free of prematurely aborted RNA sequences and/or enzyme reagents used in in vitro synthesis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 1, 2018
    Assignee: TRANSLATE BIO, INC.
    Inventors: Michael Heartlein, Frank DeRosa, Anusha Dias, Shirang Karve
  • Patent number: 9957500
    Abstract: A continuous flow nucleic acid extraction apparatus comprising a piston column apparatus for the extraction of nucleic acids from a nucleic acid sample. The disclosure also includes a method of using the continuous flow nucleic acid extraction apparatus.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: May 1, 2018
    Assignee: Stem Arts Projects, LLC
    Inventors: Abraham Oommen, Matthew Greenleaf, Adam Koch
  • Patent number: 9957501
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: May 1, 2018
    Assignees: Sangamo Therapeutics, Inc., University Of Washington
    Inventors: Andreas Reik, John A. Stamatoyannopoulos, Jeff Vierstra
  • Patent number: 9957502
    Abstract: The present invention relates to a single-stranded nucleic acid molecule for use in a method for the production of a nucleic acid, whereby the nucleic acid molecule comprises a part A and a part B, whereby part A comprises a sequence, which corresponds at least to a partial sequence of the recognition site of a type IIS restriction enzyme, and part B comprises an arbitrary but defined sequence of nucleotides. By using such nucleic acid molecules it is possible to assemble different fragments in a sequence-independent manner and thus conduct the synthesis of a nucleic acid with recourse to standardized elements.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: May 1, 2018
    Assignee: SLONING BIOTECHNOLOGY GMBH
    Inventors: Octavian Schatz, Timothy O'Connell
  • Patent number: 9957503
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Lipid transport and metabolism gene, in particular, by targeting natural antisense polynucleotide of a Lipid transport and metabolism gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of a Lipid transport and metabolism genes.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: May 1, 2018
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman
  • Patent number: 9957504
    Abstract: Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 1, 2018
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Thazha P. Prakash, Punit P. Seth, Eric E. Swayze, Mark J. Graham
  • Patent number: 9957505
    Abstract: The present invention includes bivalent or multivalent nucleic acid molecules or complexes of nucleic acid molecules having two or more target-specific regions, in which the target-specific regions are complementary to a single target gene at more than one distinct nucleotide site, and/or in which the target regions are complementary to more than one target gene or target sequence. Also included are compositions comprising such nucleic acid molecules and methods of using the same for multivalent RNA interference and the treatment of a variety of diseases and infections.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: May 1, 2018
    Assignee: HALO-BIO RNAI THERAPEUTICS, INC.
    Inventor: Todd M. Hauser
  • Patent number: 9957506
    Abstract: Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 1, 2018
    Assignee: Cornell University
    Inventors: Juan R. Cubillos-Ruiz, Laurie H. Glimcher
  • Patent number: 9957507
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: May 1, 2018
    Assignees: ALNYLAM PHARMACEUTICALS, INC., LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
    Inventors: Dinah Sah, Pamela Tan, Webster Cavenee, Frank Furnari, Maria del Mar Inda Perez, Rudy Bonavia
  • Patent number: 9957508
    Abstract: Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the oligonucleotides to treat long QT syndrome in a subject are disclosed. The oligonucleotides include antisense sequences corresponding to sites termed DSE-1 and DSE-2 in intron 9.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 1, 2018
    Assignee: Oregon Health & Science University
    Inventors: Zhengfeng Zhou, Qiuming Gong, Matthew Stump
  • Patent number: 9957509
    Abstract: Methods for making synthetic gene clusters are described.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 1, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ethan Mirsky, Karsten Temme, Christopher A. Voigt, Dehua Zhao
  • Patent number: 9957510
    Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription or transcription or transcriptional control using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 1, 2018
    Assignee: Battelle Energy Alliance, LLC
    Inventors: Brady D. Lee, David N. Thompson, William A. Apel, Vicki S. Thompson, David W. Reed, Jeffrey A. Lacey