Abstract: An orthotic device for assisting a user in walking includes an underarm support assembly configured to support a user's weight without damage to their nerves, and upright support pivotally connected to the underarm support assembly and a ground engaging assembly pivotally connected to the upright support. In one embodiment, the underarm support assembly is spring biased relative to the upright support to bias the upright support to an orientation substantially perpendicular to a longitudinal dimension of the underarm support. The ground engaging assembly is also biased to bias the ground engaging assembly to a position perpendicular to the longitudinal axis of the upright support while allowing the ground engaging assembly to pivot about an axis perpendicular to the longitudinal dimension of the upright support and about an axis parallel to the longitudinal dimension of the upright support.

Abstract: Methods, systems, and products estimate distances to aid a visually impaired user of a mobile device. As the user carries the mobile device, a camera in the mobile device captures images of a walking cane. The images of the walking cane are analyzed to infer a distance between a tip of the walking cane and the mobile device. The distance may then be used by navigational tools to aid the visually impaired user.

Abstract: A massage mechanism includes a housing, a massage rock arm group, massage heads, and a drive apparatus. The massage rock arm group includes a left rock arm group and a right rock arm group. Each rock arm group may rock under limitation of spacing grooves and spacing shafts when driven by the drive apparatus. The drive apparatus implements asynchronous actions of the left rock arm group and the right rock arm group. A swing arm connected in a seesaw manner is disposed on each rock arm, so that the massage heads can automatically fit an S curve of a back of a human body, and can be automatically attached to the human body. The present application implements a synchronous kneading function, an asynchronous rubbing function, and a function of performing massage by massage heads that can be automatically attached to a human body, thereby improving user experience.

Abstract: A manipulation therapy apparatus, system, and method is disclosed which allows a user to perform manual manipulation therapy through traction to a treatment area on their own, to easily control the amount and direction of manipulation without the need for lubrication. The manipulation therapy apparatus comprises a vacuum chamber with a handle and an air cavity, a skin sealing gasket, a pressure relief valve, and a brace.

Abstract: The present invention provides a device with a pressure control system and methods for controlling the application of negative pressure to an external surface of an individual for creating and/or maintaining patency of the upper airway passage. The device is configured to fit under the chin of a subject at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The pressure control system contains control module elements that may include circuit board elements, digital output barometer elements, sensor elements, processing elements and memory elements to optimize device function and safety of the device through regulation of the flow rate of the air pump.

Abstract: A seat assembly includes first and second bladders and a controller. The first bladder has a sensor configured to detect a pressure of the first bladder. The controller is configured to inflate the first bladder to a target pressure, as detected by the sensor, and to inflate the second bladder based on time expended for the first bladder to be inflated to the target pressure.

Abstract: A therapeutic roller includes an elongate, cylindrical body having an elastomer surface forming a tread pattern, a thermoplastic core interior to the surface, and an adhesive layer affixing the surface to the core.

Abstract: Aspects of the present disclosure involve an attachment system that combines a fitness mat to another fitness related accessory. The accessory attachment attaches to a fitness mat but is not limited to such attachment. The fitness accessory attachment may include an apparatus with internal weights. The fitness accessory may have detachable and adjustable handles with a removably adjustable and slidable attachment mechanism. The provided handle caps can be removed for various reasons such as using connecting pieces or adding weight to the interior of the handles. Fitness bands or any training tools available can run through the fitness accessory apparatus' core and connect to the attachment mechanism provided on the handles for training use. This system also provides compaction for travel and ease of portability.

Abstract: A system and method for the present invention utilizes a generator, in combination with a radiation unit, to direct waveform energy towards a target tissue using a predetermined protocol directed by titration-like feedback. The effect of the waveform energy on cellular structures of the target tissue is periodically monitored, and the predetermined protocol is halted when the cellular structure has been transformed into a desired phenotype.

Abstract: Devices, mediums, systems and methods for promoting female sexual arousal are provided and described. In one embodiment, the device includes a pump for evacuating a suction chamber when attaching the suction chamber to the female's tissue and a controller configured to self-regulate to turn on and off the pump to maintain a certain level of pressure. The controller is additionally or alternatively configured to activate the pump and to activate a feedback indicator distinct from the pump upon the sensor detecting a pressure value above ambient pressure whereby the feedback indicator advises the female as to the status of evacuation. The device can further additionally or alternatively include at least one sensor for measuring the temperature of the at least one stimulator in the vicinity of the stimulation and a controller electrically coupled to the at least one stimulator and the at least one sensor for controlling the at least one stimulator during a maximum power session.

Abstract: An elevation device used in the performance of cardiopulmonary resuscitation (CPR) includes a base and an upper support pivotably coupled to the base. The upper support is configured to elevate the individual's upper back, shoulders and head when pivoted. The upper support is expandable lengthwise. The upper support includes a neck support that is configured to support the individual's spine in a region of the individual's C7 and C8 vertebrae throughout elevation of the upper back, shoulders and head.

Abstract: A soaking basin is provided having a magnetic jet assembly positioned to provide a therapeutic liquid circulation within the basin. The magnetic jet includes an impeller assembly and a drive assembly. The impeller assembly operatively coupled to the magnetic drive assembly only via magnetic attraction, such that a basin wall and a disposable liner are disposed between the impeller assembly and the magnetic drive assembly.

Abstract: A device for storing pharmaceuticals that includes a bottom portion having wells and a lid having correlating well covers. The wells and cover are manufactured from an insulating material which protects the medication from heat and moisture. The bottom portion and lid preferably includes matching tabs to assist the user in lining up the lid with the bottom. The device may include a child resistant rim on the bottom portion that “locks” the lid onto the device when it is closed. The lid of the device may include a protrusion which interlocks with a complimentary indentation in the bottom of an additional device to allow for easy transport of additional pharmaceuticals. The device may further include a hanger hole for easy transport of the device.

Abstract: A bio-container assembly that includes a bio-container having an interior surface, an exterior surface, and a container thickness from about 0.2 mm to about 2 mm; at least one port coupled to the bio-container; a holder element comprising a polymeric material; and a cushion affixed to the holder element in contact with one or more primary exterior surfaces of the bio-container. Further, the element and the cushion are configured to enclose the bio-container. The holder element may also include a window, the bio-container being viewable through the window. The holder element may also include one or more of the following features affixed to it: a handle, a plurality of feet, a plurality of ribs, and a plurality of tabs.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: The protecting package for a flexible pouch specially designed to contain a biopharmaceutical fluid, includes two frames which respectively form a lower frame and an upper frame and which have a peripheral area, respectively to a main plane of the frames, each frame has an opening on a central area, the two frames are fixed to each other such that they are able to respectively surround two plates which sandwich the flexible pouch.

Abstract: The invention relates to a plastic container product, in particular produced by the blow-molding, filling, and sealing method, having a container wall which can be pierced by means of a cannula in predefinable areas for the purpose of access to the container content. Said plastic container product is characterized in that, in order to avoid punched parts which arise when the container wall is pierced with a cannula, the mathematical product of the container wall thickness in the piercing area and the tensile modulus of the plastic material to ISO 527 is less than 400 MPa·mm, in particular preferably less than 300 MPa·mm.

Abstract: A bio-container that includes a single-use container having an interior surface, an exterior surface, and a container thickness from about 0.2 mm to about 2 mm; and at least one port coupled to the container. Further, the container has a glass composition with no materials that are leachable in excess of a Permitted Daily Exposure (PDE) upon exposure to contents of the container. In some implementations, the container can include a compressive stress region that extends to a selected depth in the thickness and a maximum compressive stress at one or both of the interior and exterior surfaces. Further, the container can comprise a laminated sheet having a plurality of glass layers spanning the container thickness. These layers can comprise glass compositions with a CTE mismatch and the compressive stress region is based at least in part on the CTE mismatch.

Abstract: The protecting body for a flexible pouch is specially designed to contain a biopharmaceutical fluid. It includes two substantially planar plates which respectively form a lower surface and an upper surface and which are fixed to each other. The two plates are able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and includes, on a peripheral side, at least one opening able to receive at least one port of the flexible pouch.

Abstract: Methods and systems for a cartridge assembly for use with an injection system are provided. An example cartridge assembly may include an ampule containing a pharmaceutical product that is sealed at a distal end with a pierceable diaphragm. The cartridge assembly may also include a hub comprising a proximal portion defining a cavity that is configured to engage the distal end of the ampule and a piercing member positioned within the cavity. The piercing member may include a fluid pathway between a proximal end portion comprising an opening and a distal end in fluid communication with a distal opening of the hub. The proximal end portion may engage the pierceable diaphragm, and the piercing member may apply a force to the pierceable diaphragm in the inactivated position without penetrating the pierceable diaphragm.

Abstract: In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

Abstract: This invention relates to modifications to the traditional manually operated pill counting tray that is broadly used throughout the world to provide features that permit semi-automatic operation that is faster and more accurate than manual-only operation when counting pharmaceutical pills. The tray modifications are based on electronic weight-based sensing technology including the addition of (1) a weighing load sensor to determine the weight of the pills to be counted, (2) a motion sensor and latch for the trough lid to aid operation and performance, (3) a microprocessor that can convert the measured weight of the pills to a pill count, and (4) an output display to show the number of pills counted. This apparatus includes novel features to improve pill counting speed and accuracy, as well as ease of use, that are only possible when employing electronic counting.

Abstract: Disclosed is a blister pack smart dispensing package that has an overlay with conductors located over blister pack pockets that are broken when a user retrieves a solid medication, such as a pill, from the blister pack. The date and time that the user retrieved the solid medication from the smart pack is recorded by an electronics and communications package on the smart pack. A local communications device then receives this adherence data and transmits this data to a server, which generates a data structure containing adherence data. A blister pack overlay can be used which changes colors to indicate that the medication is about to expire, or has expired.

Abstract: A spring loaded nipple assembly includes a cover including a top wall and a perimeter wall that is attached to and extends downwardly from the top wall. The perimeter wall has a cylindrical shape and the top wall has a central opening extending therethrough. A nipple is integrally coupled to the top wall and extends upwardly therefrom. The nipple extends around the opening and forms a seal around the opening. The nipple has a distal end with respect to the top wall and the distal end has an aperture extending therethrough. A threading engagement member is positioned on an inner surface of the perimeter wall. The threading engagement member engages threading on a neck of a fluid container.

Abstract: Silver sulfadiazine-immobilized inorganic fillers are described, and their synthesis is presented. The fillers are believed to have utility in dental composites and dental adhesives to achieve potent, long-term, and none-leaching antimicrobial effects.

Abstract: The present invention relates to a kit of parts comprising Paste (A), Paste (B) and Paste (C), the pastes being characterized as follows: Paste (A) comprising at least one polyorganosiloxane with at least two olefinically unsaturated groups, and at least one organohydrogenpolysiloxane, at least one alkylsiloxane having at least one carbinol, silanol, alkoxy, carboxyl or amino group, optionally filler(s) and optionally additive(s); Paste (B) comprising at least one polyorganosiloxane optionally with olefinically unsaturated groups, at least one addition cure catalyst, optionally at least one alkylsiloxane having at least one carbinol, silanol, alkoxy, carboxyl or amino group, optionally filler(s) and optionally additive(s) Paste (C) comprising a softener, a condensation cure catalyst, optionally filler(s), and optionally additive(s) optionally at least one polyorganosiloxane optionally with olefinically unsaturated groups.

Abstract: According to the present invention, provided is a core-shell structured chromic microcapsule having a size of 50-1,500 ?m, comprising: a core comprising a colorant core (A) and an optional inner color layer (B); and a shell comprising a pressure sensitive destructible wall layer (C) encompassing the core, an optional outer color layer (D) and an optional outermost protective layer (E), wherein the colorant core allows a high content of a colorant to be contained, and the pressure sensitive destructible wall layer comprises carbon dioxide particles and a binder comprising one or more wall-forming materials and one or more lipid-base materials.

Abstract: A cosmetic or dermatological composition in the form of an oil-in-water nanoemulsion, including: a lipophilic phase (a) including at least one hydrocarbonated oil comprising at least one isoparaffin, and at least one cycloalkane, an emulsifying system (b) including at least one non-ionic emulsifier, and an aqueous phase (c), where the ratio between the lipophilic phase (a) and the emulsifying system (b) is higher than, or equal to, 0.5 in terms of weight.

Abstract: Cosmetic compositions comprising water, at least one estolide ester compound of Formula (3) wherein n is from 1 to 10, preferably from 2 to 8, and R is selected from branched or linear C3-20-alkyl, and B) optionally at least one surfactant component B, C) optionally at least one thickener component C, D) optionally at least one hair conditioning component D, and E) optionally at least one further component E, different to A to D, can be used for improved hair treatment.

Abstract: Methods and kits for treating hair or preventing damage in the relaxing of hair are disclosed herein. Hair that is damaged during a relaxing treatment with hydroxide-containing relaxing agents, can be treated with formulations containing one or more active agents. The active agent formulations can be applied simultaneously with the hair relaxing formulation, or optionally applied immediately following application of the relaxing formulation, to reduce damage and breakage. Use of the active agent formulation along with a relaxing treatment can be used to control the level of curl achieved or retained in the relaxed hair, as compared to the natural amount of curl in the untreated hair.

Abstract: The present invention relates to an oral care composition having an anionic surfactant, a cationic or amphoteric surfactant, and a potassium salt, wherein the oral care composition does not include a non-ionic surfactant.

Abstract: Disclosed herein are teeth whitening compositions generally including an oxidizing agent (e.g., a peroxide), and an activating agent that has an emission wavelength between about 400 nm and about 570 nm (e.g., Eosin B). Methods of employing these compositions to whiten teeth, methods of making these compositions and kits that include some or part of the composition ingredients, are also described.

Abstract: This application provides, among other things, novel aqueous biphasic compositions comprising two distinct aqueous phases, useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with anionic polymers, e.g. that protect against erosion and staining, by addition of a stabilizing amount of a polyamine, e.g. lysine, and methods for making and using the same.

Abstract: This application provides, among other things, novel aqueous biphasic compositions comprising two distinct aqueous phases, useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with anionic polymers, e.g. that protect against erosion and staining, by addition of a stabilizing amount of a polyamine, e.g. lysine, and methods for making and using the same.

Abstract: The present invention relates to the use of a composition comprising a peroxidic compound and a particular, generically defined copolymer for tooth bleaching.

Abstract: A composition for visible light dryable nail coating includes a base acrylate copolymer; a photo-initiator; and a photo-initiator monomer; wherein the photo-initiator is able to initiate natural light polymerization of chemically unsaturated monomers and prepolymers. A method for applying a visible light dryable nail coating includes steps of: applying a visible light dryable nail coating on a nail surface; curing the visible light dryable nail coating by a light source; and removing the visible light dryable nail coating from the nail surface in a solvent.

Abstract: A skin adhesive sheet is disclosed which is good in tackiness to the skin surface, does not easily dry even when used for a long time, can maintain flexibility, and is small in the shape variation. The skin adhesive sheet includes a copolymer containing the following components A and C as polymerization components, and having a water content less than 10% by mass: component A: a polysiloxane macromonomer having a plurality of polymerizable functional groups per molecule, and having a number average molecular weight of 6,000 or more; and component C: a polymerizable monomer having an alkyl group and having no fluoroalkyl group.

Abstract: Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting ?2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Abstract: The present invention relates to a sublingual dosage form comprising decarboxylated cannabis plant material, and a dispenser for delivering at least one pharmacologically active cannabinoid from the decarboxylated cannabis plant material contained inside the dispenser into the sublingual cavity of a subject when the dispenser is placed within the subject's sublingual cavity with the decarboxylated cannabis plant material contained therein. Also disclosed are a method and apparatus for preparing the sublingual dosage form, and compositions and kits comprising the sublingual dosage form.

Abstract: Topical compositions containing at least one ingredient that stimulates Mir-146a activity in skin cells, methods for treating skin and methods for screening for ingredients that stimulate Mir-146a activity.

Abstract: A transdermal composition comprising ibuprofen or salts thereof and a gelling agent which can be used for the treatment of such disorders as pain, inflammation, arthritis, muscle spasm and associated symptoms in humans and animals.

Abstract: An implantable device comprising a nanochanneled membrane is described. The device uses nanofluidics to control the delivery of diagnostic and/or therapeutic agents intratumorally. The devices can be used for chemotherapy, radiosensitization, immunomodulation, and imaging contrast.

Abstract: Disclosed herein are methods for modulation of gel temperature of poloxamer-containing formulations. Also described herein are sustained release pharmaceutical formulations that gel upon contact with the body and are administered by direct application of these compositions and formulations onto or via perfusion into the targeted structure(s).

Abstract: The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, nm) of 100-500 nm, where the oil phase comprises clopidogrel free base dispersed in pharmaceutical acceptable oil(s). The emulsion uses clopidogrel free base or premix of clopidogrel free base in oil(s) as the starting materials and may also contain one or more excipients such as surfactant and or co-surfactant, osmotic agent, pH adjustment agent, antioxidant, preservative, sweetener, and/or suspending agent, etc.

Abstract: The present disclosure provides an apparatus and methods of use for isolating particles. An example apparatus includes (a) a vessel defining a pressurizable chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet of the pressurizable chamber at the proximal end of the vessel, (c) a nozzle positioned within the pressurizable chamber, wherein the nozzle includes an inlet tube in fluid communication with the inlet of the pressurizable chamber, wherein the nozzle includes an outlet aperture, wherein the nozzle is adjustable to alter a distance between the proximal end of the vessel and the outlet aperture of the nozzle, and wherein the nozzle is adjustable to alter an angle between a longitudinal axis of the vessel and a longitudinal axis of the nozzle, and (d) an outlet of the pressurizable chamber at the distal end of the vessel.

Abstract: The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such formulation and the use of such formulation in the treatment of gastrointestinal disorders.

Abstract: The present invention relates to a rivastigmine-containing sustained-release pharmaceutical composition and, more specifically, to a rivastigmine-containing sustained-release pharmaceutical composition, which is a sustained-release preparation containing a pH-dependent delayed release phase, wherein, by controlling the release of the pharmaceutical composition to be minimized in the stomach at the initial stage of administration, the pharmaceutical composition can lower the maximum blood concentration (Cmax) compared with existing products while arriving at an effective blood concentration, thereby reducing side effects, and thereafter, maintaining the effective blood concentration through the sustained-release of main ingredients.

Abstract: Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Abstract: The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of treatment. In one embodiment, the oral dosage form can include a therapeutically effective amount of testosterone undecanoate and a pharmaceutically acceptable carrier. The dosage form can be formulated such that, when measured using a USP Type II apparatus in 1000 mL of 8 wt % Triton X-100 in water at 37° C. and 100 rpm, the oral dosage form releases at least 20% more testosterone undecanoate after the first 120 minutes than an equivalent dose testosterone undecanoate containing oral dosage form without the pharmaceutically acceptable carrier.

Abstract: Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.