Abstract: Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.

Abstract: Antibodies (e.g., isolated antibodies) that specifically bind to human integrin ?8 and inhibit adhesion of latency associated peptide (LAP) to ?v?8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin ?8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to ??8 with an IC50 below 5 nM.

Abstract: The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.

Abstract: The disclosure relates to uses and regimens for accelerating/improving physical recovery in a patient with disuse atrophy triggered by reduced mobility due to a hip fracture and consequent major surgery, which employ a therapeutically effective amount of a myostatin antagonist, e.g., a myostatin binding molecule, e.g., a myostatin antibody or an ActRII receptor binding molecule, an ActRII receptor antibody, such as the bimagrumab antibody.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies that bind CD123, CD123-antibody binding fragments and derivatives of such antibodies, and CD123-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

Abstract: The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.

Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.

Abstract: The present invention provides an anti-human Notch4 antibody or a Notch4 binding fragment thereof that may have neutralizing activity against human Notch4, as well as a pharmaceutical composition comprising the same as the active ingredient. The present inventors obtained a mouse anti-human Notch4 antibody that has high neutralizing activity and binding affinity towards human Notch4 and determined the complementarity determining region (CDR) sequence of the mouse anti-human Notch4 antibody. This enabled the production of a humanized antibody comprising the variable region of heavy and light chains as well as the CDR sequence of the mouse anti-human Notch4 antibody.

Abstract: The present invention is relevant to the generation of multi-specific antibodies, antibodies that are distinguished by their ability to bind to multiple antigens with specificity and with affinity. In particular, the present invention is related to bi-specific antibodies.

Abstract: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Abstract: A method for manufacturing a fibrillated cellulose powder suitable for being dispersed in an aqueous medium, comprising a step of adding a monovalent salt (e.g., sodium chloride, potassium chloride, and lithium chloride) to a fibrillated cellulose suspension, followed by a lyophilization step to provide the fibrillated cellulose powder. Also disclosed are a method of dispersing the fibrillated cellulose powder comprising the method for manufacturing with the further steps of suspending the fibrillated cellulose powder in an aqueous medium and subsequent dialysis of the suspension.

Abstract: A method for catalytic oxidation of cellulose using a heterocyclic nitroxyl radical as catalyst and main oxidant acting as oxygen source comprises, before the catalytic oxidation of the cellulose, pretreatment of the cellulose—in an alkaline pretreatment step, where the cellulose is treated in alkaline solution having hydroxide concentration of above 0.3 M, and—in a washing step, where the cellulose treated in the alkaline solution is washed to lower the pH.

Abstract: The present invention relates to a compound which is a phenyl glycidyl ether adduct of maltodextrin and its method of preparation. The compound of the present invention is useful as an open time additive in paint formulations.

Abstract: The present invention relates to an integrated process for processing and utilizing every part of the guayule plant (Parthenium argnetatum) which comprises the following steps in sequence: separating the stem and branches from the leaves of said plant with a mechanical treatment; treating the leaves to produce waxes and essential oils, and a fraction containing cellulose, hemicellulose (carbohydrates) and, to a minor extent, salts, organic compounds and lignin; extracting from the stem and branches a liquid phase, so forming a first solid woody residue, indicated with bagasse in the present text; treating said first solid woody residue to prepare sugars, resin, rubber and lignin.

Abstract: The present teachings show that it is possible to polymerize 1,1-disubstituted alkene compounds in a solution (for example using one or more solvents). Polymerization of 1,1-disubstituted alkene compounds in an solution provides opportunities to better control the polymerization compared with bulk polymerization. The solution polymerization techniques can be employed for preparing homopolymers, copolymers (e.g., random copolymers), and block copolymers.

Abstract: Films or sheets of polypropylene, particularly biaxially oriented polypropylene (BOPP) films, exhibiting excellent physical and mechanical properties combined with good processing characteristics can be prepared from propylene polymers prepared in the presence of Ziegler-Natta catalysts comprising a succinate and a diether compound.

Abstract: Propylene copolymer having a melt flow rate MFR2 (230° C.) in the range of more than 0.5 to below 2.5 g/10 min, a xylene cold soluble content (XCS) in the range of 30.0 to 40.0 wt-%, a comonomer content in the range of more than 7.5 to 12.0 wt.-%, wherein further the comonomer content of xylene cold soluble (XCS) fraction of the propylene copolymer is in the range of 16.0 to 28.0 wt.-%.

Abstract: The present invention provides multifunctional monomers, including, but not limited to include multifunctional methylene malonate and methylene beta-ketoester monomers; methods for producing the same; and compositions and products formed therefrom. The multifunctional monomers of the invention may be produced by transesterification or by direct synthesis from monofunctional methylene malonate monomers or methylene beta-ketoester monomers. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

Abstract: Herein, we describe polymerized ionic liquids, demonstrate the synthesis of polymerized ionic liquids, and demonstrate the polymerization of triazolium monomers. One embodiment shows the polymeriazation of the triazolium monomers with bis(trifluoromethanesulfonyl)imide anions. In another embodiment we show the feasibility of copolymerizing with commodity monomers such as styrene using free radical polymerization techniques.

Abstract: The present invention provides an optically transparent peroxide cured article made from a peroxide curable butyl rubber ionomer comprising repeating units derived from the reaction product of one or more multiolefin monomers and at least one nitrogen or phosphorous based nucleophile comprising a pendant vinyl group. A process is also disclosed for making the optically transparent article.

Abstract: The present disclosure relates to a process for polymerization of hydrocarbons. In accordance with the process of the present disclosure, a hydrocarbon and a photo-initiator is introduced in a reaction vessel and then agitated for a predetermined time period. In the next step, the reaction vessel containing the agitating hydrocarbon and the photo-initiator is irradiated with visible light to obtain a polymerized hydrocarbon. The process of present disclosure is carried out in an atmosphere containing oxygen less than 0.65% in the reaction vessel.

Abstract: A method of producing ultra high molecular weight (UHMW) C4-C30 ?-olefin drag reducing agent (DRA). The method includes polymerizing in a reactor a first ?-olefin monomer in the presence of catalyst and hydrocarbon solvent to produce the DRA. The catalyst consists essentially of at least one tertiary monophenyl amine having a formula R1R2N-aryl, where R1 and R2 are the same or different, and each is a hydrogen, an alkyl, or a cycloalkyl group, where at least one of R1 and R2 contain at least one carbon atom; at least one titanium halide having a formula TiXm, where m is from 2.5 to 4.0 and X is a halogen containing moiety; and at least one cocatalyst having a formula AlRnY3-n where R is a hydrocarbon radical, Y is a halogen or hydrogen, and n is 1-20. Further, the catalyst is absent of a carrier or support.

Abstract: A process capable of producing an ethylene/?-olefin copolymer having a high molecular weight even under the conditions of a high polymerization temperature is provided. The process for producing an ethylene/?-olefin copolymer includes copolymerizing ethylene and an ?-olefin having 3 or more carbon atoms in the presence of an olefin polymerization catalyst including a crosslinked metallocene compound (A) represented by the following general formula [I] and a cocatalyst component (B). In the general formula [I], Y is selected from a carbon atom, etc., M is a hafnium atom or the like, R1 to R12 are each selected from a hydrogen atom, a hydrocarbon group, etc., R13 and R14 are each a substituted aryl group or the like, at least one of R13 and R14 is a substituted aryl group having one or more electron-donating substituents having a Hammett substituent constant ? of not more than ?0.2, Q is selected from a halogen atom, etc., and j is an integer of 1 to 4.

Abstract: Linear low density polyethylene (LLDPE) is produced from an ethylene-only feed over a tandem catalyst system consisting of a phenoxy-imine titanium trimerization catalyst and a silylene-linked cyclopentadienyl/amido titanium polymerization catalyst co-supported on the same methylaluminoxane/silica particles. The level of 1-hexene incorporation in the LLDPE can be controlled by varying the ethylene pressure. Tandem, co-silica-supported ethylene trimerization and ethylene/1-hexene copolymerization catalysts produce linear low density polyethylene (LLDPE) from an ethylene-only feedstock. The percentage 1-hexene incorporation in the LLDPE may be varied by adjusting the amounts of the two catalysts on the silica support.

Abstract: The present invention provides a polymer compound containing a repeating unit shown by the following general formula (1). There can be provided a polymer compound usable in a negative resist composition that can achieve high resolution of 50 nm or less and small LER and cause very few defects, a negative resist composition using the polymer compound, and a patterning process using the negative resist composition.

Abstract: A copolymer includes a first structural unit selected from Chemical Formula 1, Chemical Formula 2, and a combination thereof and a second structural unit selected from Chemical Formula 3, Chemical Formula 4, and a combination thereof; and a composition including the copolymer and an article manufactured from the composition are provided. Definitions of Chemical Formulae 1 to 4 are the same as described in the detailed description.

Abstract: The present invention is directed to a copolymer of 1,3-butadiene or isoprene and a monomer of formula I or formula II where R1 is a covalent bond or C1 to C8 linear or branched alkanediyl; R2, R3, R4 are independently C1 to C8 linear or branched alkyl or —OR6, where R6 is C1 to C8 linear or branched alkyl, with the proviso that at least one of R2, R3, and R4 is —OR6, and where R5 is hydrogen or C1 to C8 linear or branched alkyl. The invention is further directed to a rubber composition including the copolymer, and a pneumatic tire containing the rubber composition. The invention is further directed to a method of making such a copolymer.

Abstract: Disclosed are a modified conjugated diene-based polymer represented by Chemical Formula 1, a method of preparing the same, and a rubber composition including the same.

Abstract: Cold flow-reduced polymers having good processing characteristics have, at the ends of the polymer chains, a silane-containing carboxyl group of the formula (I) where R1 and R2 are the same or different and are each an H, alkyl, alkoxy, cycloalkyl, cycloalkoxy, aryl, aryloxy, alkaryl, alkaryloxy, aralkyl or aralkoxy; R3 and R4 are the same or different and are each an H, alkyl, cycloalkyl, aryl, alkaryl or aralkyl radical; A is a divalent organic radical.

Abstract: A wax dispersant for a toner including a polymer obtained by graft polymerization of a styrene-acrylic resin onto a hydrocarbon compound, wherein the styrene-acrylic resin has a structural segment derived from a saturated alicyclic compound, and a toner including a toner particle that contains a binder resin, a wax, and a polymer obtained by graft polymerization of a styrene-acrylic resin onto a hydrocarbon compound, wherein the styrene-acrylic resin has a structural segment derived from a saturated alicyclic compound.

Abstract: Provided is a polycarbonate-modified acrylic resin obtained by reacting an unsaturated monomer mixture (B), which contains, as essential components, methyl methacrylate, an unsaturated monomer (b1) having a hydroxyl group, an unsaturated monomer (b2) having a carboxyl group, and an unsaturated monomer (b3) having an alkyl group of 2 to 8 carbon atoms, in the presence of a polycarbonate diol (A) which is produced using 1,5-pentanediol and 1,6-hexanediol as starting materials, characterized in that the mass ratio of the unsaturated monomer (b2) in the unsaturated monomer mixture (B) is in the range of 0.1% to 1.6% by mass. The polycarbonate-modified acrylic resin has high adhesion to a plastic substrate and is capable of forming a coating film having excellent abrasion resistance, chemical resistance, feel, and appearance. Therefore, the polycarbonate-modified acrylic resin can be suitably used for a coating.

Abstract: A radical-polymerizable resin composition comprising one or more metal-containing compounds (A) selected from a metal soap (A1) and a ?-diketone skeleton-containing metal complex (A2); one or more thiol compounds (B) selected from a secondary thiol compound (B1) and a tertiary thiol compound (B2); and a radical-polymerizable compound (C) can stably cure under a dry condition, in water and in seawater and further on a wet substrate. The radical-polymerizable resin composition is useful as a repairing material for inorganic structure, a radical-polymerizable coating composition, a concrete spall preventing curable material, a reinforcing fiber-containing composite material, etc.

Abstract: Polyisocyanate-based polymers are formed by curing a reaction mixture containing at least one polyisocyanate and at least one isocyanate-reactive compound having at least two isocyanate-reactive groups in the presence of a tertiary amine catalyst having a molecular weight of up to 300 and from 0.01 to 1.0 mole per mole of the tertiary amine compound(s) of a non-protic, non-catalytic, metal-containing Lewis acid.

Abstract: In a resin film configured to have a cured product layer formed from a curable resin composition on the surface of a substrate, the present invention aims to ensure not only the processability and other properties of the resin, but also the performance required for recent high-hardness coating films. The above problem was solved by a curable resin composition comprising the intended polyfunctional urethane (meth)acrylate oligomer, which is capable of forming a cured product layer when applied to and cured on a resin substrate.

Abstract: The present invention relates to a method for preparing a linear or branched hydroxylated and/or carboxylated polyester resin that is free of unsaturated fatty acids, comprising reacting an acid component with an alcohol component, said acid component comprising at least one C4 to C6 polycarboxylic acid or anhydride, and at least one C8 to C54 polycarboxylic acid or anhydride, and said alcohol component comprising at least one biobased polyol having a functionality of at least 2 bearing a 1,4:3,6-dianhydrohexitol unit, and at least one of two polyols b2) and b3).

Abstract: The present invention relates to a copolycarbonate and a molded article comprising the same. The copolycarbonates according to the present invention has a structure in which a specific siloxane compound is introduced in a main chain of the polycarbonate, and has effects of improving impact strength at room temperature, impact strength at low temperature, and melt index properties.

Abstract: Provided is a method of preparing poly(alkylene carbonate) using a molecular weight regulator in a process of preparing a copolymer of carbon dioxide/epoxide using a novel complex synthesized from salen-type ligand including a quaternary ammonium salt as a catalyst. According to the present invention, even though the molecular weight regulator is used, an activity of the catalyst may be stably maintained, whereby the low molecular weight of poly(alkylene carbonate) having a desirable level may be effectively provided. In addition, it is expected that since the novel complex as the catalyst of the present invention has a simple structure as compared to the existing copolymerization catalyst, due to the economical preparation cost thereof, the novel complex may be effectively applied to a large-scale commercial process.

Abstract: A polymer (A) having, at one terminal moiety thereof, a terminal structure having two or more carbon-carbon unsaturated bonds. A reactive-silicon-group-containing polymer (B) having, at one terminal moiety thereof, a terminal structure having two or more reactive silicon groups.

Abstract: The present invention relates to silicone polymer ligands for binding to quantum dots. The silicone polymer ligands contain a multiplicity of amine, carboxy, and/or phosphine binding groups suitable for attachment to quantum dots. The present invention also describes a process for the preparation of quantum dot binding ligands.

Abstract: Flame retardant compositions for polyurethanes may include hydroxyl-containing poly(alkylene phosphates) that have 5 mol % or less of phosphorus from phosphorus-containing compounds having a 31P NMR resonance signal at a chemical shift in the range from 13 ppm to 18 ppm relative to 85 wt % phosphoric acid.

Abstract: A gluten-derived flame retardant macromolecule includes a phosphorus moiety chemically bonded to an amino acid side chain of a gluten protein.

Abstract: The present invention relates to a method of producing liquid crystal elastomer (LCE) based components. The method comprises the steps of (i) providing or creating micro-sized or nano-sized LCE particles, (ii) dispersing the particles in an uncured liquid polymer, (iii) aligning the nematic directors of the particles and, (iv) shaping and curing the matrix/particles mixture. The composite material formed by this method is a polymer dispersed liquid crystal elastomer (PDLCE) with custom-tailored properties which can be shaped into arbitrary forms.

Abstract: Provided are aqueous fluoropolymer dispersions containing at least one tetrafluoroethene homopolymer or tetrafluoroethene copolymer and at least one non-aromatic polyhydroxy surfactant. The dispersions contain from 0 to 100 ppm based on the total weight of the dispersion of fluorinated surfactants. Also provided are methods of coating using the dispersions and substrate coated with the dispersions.

Abstract: The present invention relates to a process for drying particulate polymers, comprising the steps of: a) providing a particulate polymer comprising from 60 wt % to 90 wt % of at least one solvent based on the total weight of particulate polymer and solvent, b) mechanically predrying the particulate polymer to a content of the at least one solvent of from 20 wt % to 50 wt % based on the total weight of particulate polymer and solvent, wherein the mechanical predrying in step b) is carried out with a roller press, and c) end-drying the particulate polymer to a content of the at least one solvent of from 0 wt % to 15 wt % based on the total weight of particulate polymer and solvent, wherein the particulate polymer is a polymer comprising repeating units of formulae I, II and/or III The present invention further relates to a process for working up particulate polymers.

Abstract: Acido-basic properties of a system containing a polymer obtained by decomposing by oxidative cleavage of a carbon-carbon double bond, and a trifunctional molecule having an alkoxysilyl group in the structure as represented by the formula (A) are changed such that the system is changed into a basic system when the system is acidic and the system is changed into an acidic system when the system is basic to combine the decomposed polymer and the trifunctional molecule, thereby introducing the alkoxysilyl group into the main chain. Furthermore, acido-basic properties of a system containing a polymer obtained by decomposing by oxidative cleavage of a carbon-carbon double bond to decrease the molecular weight, and a functional molecule having an alkoxysilyl group as represented by the formula (a) are changed in the same manner as above to combine the decomposed polymer and the functional molecule, thereby introducing the alkoxysilyl group in a molecular terminal.

Abstract: In a method for controlling shrinkage of a composite, a dried hydrophobically modified cellulose-based fiber is exposed to a slow acting resin system having a first curing time. An excess amount of the slow acting resin system is removed to separate out the pre-wetted hydrophobically modified cellulose-based fiber. The pre-wetted hydrophobically modified cellulose-based fiber is mixed with a fast acting resin system to form a mixture. The fast acting resin system has a second curing time that is less than the first curing time. The mixture is molded at a predetermined temperature. The fast acting resin system is cured prior to the slow acting resin system, and the slow acting resin system flows into free space within the curing fast acting resin system prior to the slow acting resin system being cured.

Abstract: Epoxy formulations comprising a polyfunctional epoxy resin, a solid bisphenol A epoxy resin, a phenolic end capped bisphenol A resin, a rubber epoxy adduct and a curative are provided as is their use in prepregs and as matrix materials in laminates of metal foil and fiber reinforced epoxy resins.

Abstract: Means for solving the problems The thermoplastic resin composition (X1) of the present invention comprises (A1), (B1), (C1), and optionally (D1) below: 1 to 90 wt % of an isotactic polypropylene (A1); 9 to 98 wt % of a propylene/ethylene/?-olefin copolymer (B1) containing 45 to 89 mol % of propylene-derived structural units, 10 to 25 mol % of ethylene-derived structural units, and optionally, 0 to 30 mol % of C4-C20 ?-olefin-derived structural units (a1); 1 to 80 wt % of a styrene-based elastomer (C1); and 0 to 70 wt % of an ethylene/?-olefin copolymer (D1) whose density is in the range of 0.850 to 0.910 g/cm3, wherein (A1)+(B1)+(C1)+(D1)=100 wt %.