Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Abstract: A wiring loop structure of a skin electrode pad production machine includes a first transmission means for transmitting a strip clad substrate portion, a second transmission means for transmitting a strip conductive adhesive portion, a circulation conveyor belt with plural positioning fixtures, and two laminating rollers for laminating the clad substrate portion and the conductive adhesive portion. The first transmission means includes an assembling roller disposed above an end of the circulation conveyor belt, and the positioning fixture is provided for positioning an electrode lead, and the assembling roller strip clad is provided for adhering the substrate portion to the electrode lead, and the two laminating rollers are provided for attaching the strip clad substrate portion and the conductive adhesive portion after being laminated by the two laminating rollers, so as to facilitate the electrode lead to assemble and manufacture the electrode pad.

Abstract: Systems and methods for treating a gastrointestinal condition of a patient includes minimally invasively implanting a modular stimulator system in a patient's treatment site. The modular stimulator system comprises a microstimulator module, a small power source module and a macrostimulator module that are detachably attachable to each other. For the first phase of treatment, the microstimulator module and power source are implanted with a stimulating electrode proximate a target tissue. Electrical stimulation is provided for a short period of time and treatment efficacy is evaluated through clinical results and patient reporting. If therapy is not effective, stimulation parameters can be changed and/or the implantation site can be moved. If therapy is effective, portions of the microstimulator module and/or small power source are replaced with the macrostimulator module for long term therapy of the second phase of treatment.

Abstract: Electrode arrays for biological implants are disclosed. Electrodes are arranged in such a way so that electrical traces overlap other electrical traces in a separate layer without X shaped crossing, while overlapping to a degree sufficient to prevent dielectric breakdown of the insulating, separating layer.

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

Abstract: A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity and methods for manufacturing the same. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Abstract: An implantable electrical stimulation lead including a lead body having a distal end, a proximal end, and a longitudinal length, wherein the distal end of the lead body is formed into a hook or coil shape; a plurality of electrodes disposed along the hook or coil at the distal end of the lead body; a plurality of terminals disposed on the proximal end of the lead body; and a plurality of conductors, each conductor electrically coupling at least one of the electrodes to at least one of the terminals. The lead can be used to stimulate, for example, a dorsal root ganglion with the hook-shaped or coil-shaped distal end disposed around a portion of the dorsal root ganglion.

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Abstract: Disclosed is a skin treatment device including a treatment unit inserted into skin to stimulate the skin, a holder unit for detachably mounting the treatment unit thereonto to transfer a signal to the treatment unit, and a handpiece unit for mounting the holder unit thereonto to supply the signal to the holder unit, thereby rapidly exchanging the treatment unit.

Abstract: Disclosed herein are methods and devices for stimulating an immune response to a disease in a subject, which involves passing sub-microsecond long pulses of electric fields having an amplitude between 5 kV/cm and 68 kV/cm through an abnormal growth of a subject sufficient to suppress myeloid-derived suppressor cell (MDSC) or regulatory T cell (Treg) production, increase adenosine triphosphate (ATP) or high mobility group box 1 (HMGB1) production, or stimulate dendritic cell activation in the subject.

Abstract: A device positioned in the vagina includes a sensor. The sensor data is used to determine whether a condition is met or exists to trigger a therapeutic response by the device. A device for stimulating nerves adjacent the vagina includes a nerve stimulating element coupled to a main body. The nerve stimulating element is positioned and designed to stimulate the vesical, Frankenhauser's and/or inferior hypogastric plexuses. The device may reside in the vaginal fornices. An implant is also provided which has a nerve stimulating element in contact with a uterosacral ligament. The device positioned in the vagina may be used to charge a power source for an implant, which may be a capacitor.

Abstract: In general, techniques, methods, systems, and devices for delivering high frequency neurostimulation to control one or more pelvic disorders are described. In one example, a method includes identifying, by a medical device configured to be at least partially implanted in a patient, an indication to inhibit bladder activity. The medical device generates, in response to identifying the indication, electrical stimulation therapy comprising first electrical stimulation pulses comprising a first frequency greater than or equal to about 500 Hertz and less than or equal to about 5,000 Hertz. Further, the medical device delivers the electrical stimulation therapy to a target nerve selected from a group consisting of: a sacral nerve, a pelvic nerve, a tibial nerve, and a pudendal nerve of the patient.

Abstract: Some embodiments relate to a method of treating a waste evacuation dysfunction, comprising administering transcutaneous electrical stimulation to at least one lumbar or abdominal region for at least one treatment period per day over a treatment term of at least one week.

Abstract: One example provides a nerve stimulation treatment using electrodes coupled to a user. Examples determine a target charge level and output a series of pulses from the electrodes. For each pulse outputted, examples measure a charge value of the pulse and compare the charge value to the target charge level. If the charge value is greater than the target charge level, examples reduce a strength level of a subsequent outputted pulse. If the charge value is less than the target charge level, examples increase the strength level of a subsequent outputted pulse.

Abstract: Neuromodulation devices and methods of their use are described in which a therapeutic device is configured to generate a treatment for treating pain such as the reduction of the symptoms of chronic and acute pain as well as for treating other conditions. The neuromodulation device generates an output electrical signal in the form of pulses with a fast rise-time spike waveform followed by a longer-duration, lower amplitude primary phase waveform. The output signal includes a broad range of frequency components, with time constants tuned so as to interact with specific cell membrane or cellular components. The output signal may be conducted to the patient via electrodes. The pulses are triggered at variable intervals which prevent habituation.

Abstract: Described is a system for treating traumatic memories. During a wake stage, a virtual environment is displayed to a subject. A traumatic episode that may be similar to a traumatic memory of the subject is displayed to the user in the virtual environment in a benign setting. A transcranial current stimulation (tCS) controller applies a pattern of transcranial direct current stimulation (tDCS) to the subject during the traumatic episode, such that the traumatic memory in a benign setting is associated with the pattern of tDCS. During a sleep stage, if slow-wave sleep in the subject is detected via electroencephalogram (EEG) recordings, then in a first time period, the tCS controller may a transcranial alternating current stimulation (tACS) to the subject followed by a second time period without stimulation. In a third time period, the tCS controller may apply the pattern of tDCS to the subject. The sleep stage may be repeated until a desired weakening of the traumatic memory is reached.

Abstract: An electric stimulator that effectively improves the brain function of patients suffering from brain disorders by applying electric stimulation to the brain of the patient effectively. The electric stimulator can include main electrodes H to be stuck to particular sites of the patient's body extending from the neck part to the head tip part. The particular site may be the temple part, the forehead part above the eyes, the cheek part and the rear neck part. The electric signal to be applied to the main electrodes H is set so as for weak electric current of 100 ?A or less to flow through the patient's body and stimulate the brain. In addition to the application of electric stimulation by the main electrodes H, auxiliary electrodes S may be stuck to the back of the patient.

Abstract: A system for controlling parameter settings of an auditory device includes: an auditory device processor; an auditory device output mechanism including modifiable parameter settings; an auditory input sensor that detects an environmental sound; a database in communication with the auditory device processor, the database pairing each of a plurality of sets of parameter settings with a corresponding sound profile; a memory in communication with the processor and including instructions that, when executed by the processor, cause the processor to: receive the environmental sound detected by the auditory input sensor; analyze a frequency content of the environmental sound; compare the frequency content of the environmental sound with the sound profiles stored in the database and, in response to the comparison, select one of the sound profiles; and automatically adjust the parameter settings of the auditory device output mechanism to match the set of parameter settings associated with the selected sound profile.

Abstract: Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or conditions. The systems and methods can employ a microstimulator that is configured to be placed within an anatomical structure of a subject. The microstimulator can be capacitively linked to an external electronic device to provide neuromodulation to a biological target site proximal to the anatomical structure. The microstimulator can include a body and an electrically conductive insert arranged within the body to create a capacitively coupled link with the external electronic device. The electrically conductive insert can receive a power signal from an external electronic device and convert the power signal to deliver a therapy signal to the biological target site.

Abstract: A deep brain stimulation device including: a probe (60) having a transparent distal portion, crossed by a channel (28) open at a proximal end of the probe, and including electrodes (20a, 20b, 20c, 20d) affixed to the distal portion of the probe and electrode terminals (22a, 22b, 22c, 22d) affixed to a proximal portion of the probe; an electrical housing including a channel open at its two ends and housing electrical terminals in contact with the terminals (22a, 22b, 22c, 22d) of the probe; and an electrical extension lead affixed to the housing and connected to the terminals of the housing. The channel of the housing is open at the other one of its ends and the device further includes: a waveguide (50) at least partly housed in the central channel (28) of the probe, all the way to the distal portion of the probe; and a transmitter housing capable of being connected to the waveguide (50) for the injection of a predetermined wavelength.

Abstract: Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined.

Abstract: An intracardiac ventricular pacemaker is configured to operate in in a selected one of an atrial-tracking ventricular pacing mode and a non-atrial tracking ventricular pacing mode. A control circuit of the pacemaker determines at least one motion signal metric from the motion signal, compares the at least one motion signal metric to pacing mode switching criteria; and responsive to the pacing mode switching criteria being satisfied, switches from the selected one of the non-atrial tracking pacing mode and the atrial tracking pacing mode to the other one of the non-atrial tracking pacing mode and the atrial tracking pacing mode for controlling ventricular pacing pulses delivered by the pacemaker.

Abstract: Neuromodulation devices for delivering neuromodulation therapy to distal vascular portions and proximal vascular portions and associated systems and methods. A neuromodulation device can include an elongated shaft having a proximal portion and a distal portion, each portion being sized and shaped for simultaneous positioning and deployment within respective proximal and distal vascular portions of a human vasculature. The elongated shaft can have an outer cross-sectional dimension that decrementally changes towards the distal end. The elongated shaft can also have a plurality of sections, each section configured to be independently shaped upon deployment in the intended distal or proximal vascular portion.

Abstract: Methods and systems for selecting electrical stimulation parameters for an electrical stimulation device implanted in a patient can use an iterative process for identifying electrodes for stimulation, as well as suitable stimulation parameters. The process begins with an initial set of electrode combinations to identify regions of the nerve or other tissue for stimulation. This leads to selection of other electrode combinations to test, followed by the selection of multiple electrode groups (which can include three or more electrodes) for stimulation.

Abstract: The present invention is generally directed to methods, systems, and computer program products for coordinating musculoskeletal and cardiovascular hemodynamics. In some embodiments, a heart pacing signal causes heart contractions to occur with an essentially constant time relationship with respect to rhythmic musculoskeletal activity. In other embodiments, prompts (e.g., audio, graphical, etc.) are provided to a user to assist them in timing of their rhythmic musculoskeletal activity relative to timing of their cardiovascular cycle. In further embodiments, accurately indicating a heart condition during a cardiac stress test is increased.

Abstract: An implantable photovoltaic device. The implantable photovoltaic device includes: at least two solar microcells configured to absorb sunlight; a thin film wire configured to connecting the at least two solar microcells to each other; a film configured to support the solar microcells; an upper encapsulation layer configured to encapsulate an upper side of the solar microcells and shield the solar microcells from the outside; and a lower encapsulation layer configured to encapsulate a lower side of the film and connect to the encapsulation layer. According to the idea of the present invention, it is possible to obtain a photovoltaic device which stably and harmlessly operates in a living body.

Abstract: Medical devices provide metallic connector enclosures. The metallic connector enclosures may be constructed with relatively thin walls in comparison to polymer connector enclosures to aid in miniaturizing the medical device. The metallic connector enclosures may be constructed with interior surfaces that deviate less from an ideal inner surface shape in comparison to polymer connector enclosures to allow for better concentricity of electrical connectors. The metallic connector enclosures may include a panel that allows access to the cavity of the connector enclosure where set screw blocks, lead connectors, spacers, seals, and the like may be located. Furthermore, the lead connectors within the metallic connector enclosures may be separated from the metallic connector enclosure by being positioned within non-conductive seals that reside within features included in cavity walls of the connector enclosure.

Abstract: An electrical stimulation system provides stimulation therapy to a patient. The system includes a neurostimulation lead that contacts patient tissue and couples with an implantable stimulation device, such as an implantable pulse generator, that receives stimulation parameters for providing stimulation therapy to a patient. The implantable stimulation device includes a header with a plurality of connector assemblies that receive an end of the neurostimulation lead, and a case containing a charging coil and a telemetry coil coupled to programming circuitry on a printed circuit board, which is in turn coupled to the connector assemblies via a feedthrough assembly. The telemetry coil receives data from an external programmer and transmits the data to the programming circuitry, which in turn uses the data to communicate to the connector assemblies and the neurostimulation lead to provide stimulation therapy to a patient.

Abstract: A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.

Abstract: Patient support apparatuses, such as beds, cots, stretchers, chairs, or the like, include wireless communication systems that are adapted to communicate with a non-local wireless receiver positioned outside of the healthcare facility and not associated with the healthcare facility. A computer positioned within the healthcare facility and coupled a local area network of the healthcare facility receives messages from the patient support apparatuses that have been forwarded by the non-local wireless receiver to the local area network. In some embodiments, the wireless receiver is local and positioned within the healthcare facility. In such instances, a second computer, such as a server, forwards a first subset of the patient support apparatus messages to a first computer via the local area network and a second subset of the patient support apparatus messages to a device remote from the healthcare facility. Patient support apparatuses that communicate using visible light are also disclosed.

Abstract: A system includes a first computing device comprising a processor coupled to a memory. The processor and the memory are configured to receive at least one of (i) information indicative of treatment of a victim by a first caregiver using the first computing device and (ii) information indicative of a health status of the victim; determine that treatment of the victim by the first caregiver using the first computing device is completed; and transmit the received information to a second computing device.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Methods of stimulating a target deep brain region using multiple Transcranial Magnetic Stimulation (TMS) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying TMS so that the applied TMS induces spatial summation and thereby modulation of the target deep brain region.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for modulating nerves. The medical device may include an elongate shaft having a distal region. Two or more electrodes may be positioned adjacent to the distal end region of the elongate shaft. A control unit may supply power and control algorithms to the electrodes. The control algorithm may allow the electrodes to be operated simultaneously and individually.

Abstract: The present disclosure relates to a system and method for providing a smart communication device-based light therapy service in which a light therapy device is operated in conjunction with a smart communication device and an information providing server to perform a light therapy, and when a user purchases a lightceutical clinical code corresponding to a certain disease using the smart communication device, the information providing server generates the lightceutical clinical code of the disease containing a wavelength of light, an intensity of light, an irradiation time of light, and an irradiation pattern of light and sends the generated lightceutical clinical code to the smart communication device, and the smart communication device sends the received lightceutical clinical code to the light therapy device or generates a light therapy device control signal in accordance with the lightceutical clinical code and transmits the generated light therapy device control signal to the light therapy device to operat

Abstract: A therapeutic wavelength emitter is provided with one or more infrared light bulbs disposed within a case. The case is provided with a transparent lid having a plurality of cuprorivaite particles.

Abstract: A stationary trans-skull optogenetic stimulation module is provided and includes a sleeve to be inserted and positioned in a drilled hole of a skull of a subject, an optogenetic stimulating element, and a cover. The sleeve has a large aperture portion and a small aperture portion, and the optogenetic stimulating element and the cover can be installed with or disassembled from the large aperture portion. Thus, the operation time of syringe injection and phototherapeutic irradiation can be reduced, and the operation efficiency can be increased.

Abstract: The invention, in some aspects, relates to methods to alter activity in cells and the use of such method to treat disorders and conditions. The methods involve, in part, expressing stimulus-activated opsin polypeptides in neurons involved in memory and behavior and activating the opsin polypeptides to modulate activity of cells in which they are expressed and/or cells to which the cells that express the opsin polypeptides project.

Abstract: A system and method for light stimulation within a medium. Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract: The present invention provides for devices and methods of treating wounds, including general wounds, gum disease and gingival tissues post scaling/root planning, using a diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm). Further disclosed are devices and methods capable of stimulating tissue regeneration at the site of a wound.

Abstract: A device (10) for light based skin treatment is provided. The device (10) comprises a light source (18) for providing an incident light beam (21) for treating a skin (30), optical elements for focusing the incident light beam (21) in a focal point (22) inside the skin (30), and a skin interface element (11) for, during use of the device (10), providing optical coupling of the incident light beam (21) from the device (10) into the skin (30). The skin interface element (11) comprises a transparent exit window (12) for allowing the incident light beam (21) to leave the device (10), on top of the exit window (12), a transparent mixture (13) of a polar substance and an apolar substance, and on top of the transparent mixture (13), a transparent foil (14), the transparent foil (14) being more hydrophobic than the exit window (12).

Abstract: A method and system are provided. The method includes condensing, by a processor, an original voxel-beamlet matrix stored in a memory device into a reduced dataset for proton beam simulation and therapy. The original voxel-beamlet matrix has a row for each of a plurality of voxels in a three-dimensional patient volume and a column for each of a plurality of radiation beamlets. The condensing step includes determining protobeams to be extracted from the original voxel-beamlet matrix. The protobeams are columns (i) selected from the original voxel-beamlet matrix based on comparisons performed between the columns in the original voxel-beamlet matrix or (ii) created by combining at least some of the columns in the original voxel-beamlet matrix, in a matrix condensing process. The condensing step further includes extracting the protobeams from the original voxel-beamlet matrix. The condensing step also includes storing the protobeams as the reduced dataset in the memory device.

Abstract: A method and system are provided. The method includes splitting, by a processor based on radiation beamlet contributions to neighboring voxels, at least one row in a voxel-beamlet matrix and corresponding elements of a target dose vector prior to, and in preparation for, a regression operation. The voxel-beamlet matrix has a row for each of a plurality of voxels in a three-dimensional patient volume and a column for each of a plurality of radiation beamlets. The target dose vector represents a desired energy amount for each of the plurality of voxels in the three-dimensional patient volume. The target dose vector corresponds voxel-by-voxel to rows in the voxel-beamlet matrix. The method further includes performing, by the processor, the regression operation on the voxel-beamlet matrix and target dose vector to obtain beamlet weights. The method also includes determining an actual radiation dosing scheme for a given patient based on the beamlet weights.

Abstract: A method and system are provided for converting clinical criteria constraints for a target structure of radiation therapy into a second set of constraints. The method includes selecting, by a hardware processor, a plurality of clusters of voxels in the target structure based on pre-specified criteria. The method further includes assigning, by the hardware processor, each of the plurality of clusters of voxels a respective constraint that specifies one or more bounds on a radiation dose applied to each voxel in a corresponding one of the plurality of clusters of voxels. The method also includes storing, in a memory device, the respective constraint for each of the plurality of clusters of voxels.

Abstract: A radiation therapy planning system (100) includes a radiation therapy optimization unit (124), which receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image, and generates an optimized plan (126) based on at least one modified objective function. The optimized plan (126) includes a planned radiation dose for each voxel.

Abstract: A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug.

Abstract: A method for determining MLC leaf sequences for radiation treatment includes obtaining BEV projections of a first target volume and a second target volume along one or more treatment paths of a radiation treatment plan, analyzing the BEV projections to determine one or more contiguous ranges of spatial points where there exists an interstitial region between the first target volume and the second target volume in the direction of MLC leaf motion, and determining a first set of MLC leaf sequences such that an aperture formed by the MLC in a first portion of the one or more contiguous ranges of spatial points exposes radiation to the first target volume but not the second target volume, and an aperture formed by the MLC in a second portion of the one or more contiguous ranges of spatial points exposes radiation to the second target volume but not the first target volume.

Abstract: An X-ray fluoroscopic apparatus is capable of irradiating exactly a therapeutic beam considering a specific-regional area, and in addition is able to perform an easy confirmation of the specific region even when the specific region is difficult to visually recognize by a user. A control element 30 has a DRR image generation element 31, an X-ray fluoroscopic radiograph generation element 32, a template area selection element 33, a template generation element 34, a position detection element 35, a radiation area projection element 36, a specific region projection element 37, a superimposition element 38, an image display element 39, a gating element 40 and a memory storing element 41 that stores a variety of data including image data.

Abstract: Devices and method for magnetic resonance guided rotation of an object positioned within a bore of a magnetic resonance device are provided. The devices and method involve obtaining magnetic resonance measurements and rotating the object based on at least one magnetic resonance measurement. Systems comprise at least one irradiation unit configured to deliver radiation to a specified target in a treated object, and a magnetic resonance device (MRD) configured to derive magnetic resonance images of the treated object, the MRD comprising a positioning unit configured to position the treated object at at least two positions, wherein the MRD is configured to detect at least two locations of the specified target at the corresponding at least two positions of the treated object, wherein the system is further configured to adjust the at least one irradiation unit to deliver radiation to the detected at least two locations.

Abstract: Provided is a method for measuring a depth profile of a particle beam, the method including providing first sensors in a first direction in auditory organs of a human body, providing second sensors in a second direction that intersects with the first direction on a top of a head and in a mouth of the human body, providing a particle beam into the head of the human body, detecting an acoustic signal generated by the particle beam through the first and second sensors, and calculating a depth profile of the first and second directions of the particle beam corresponding to a Bragg peak position of the particle beam in the head using the acoustic signal.