Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).

Abstract: The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass.

Abstract: Novel labeled compounds and metabolites thereof are disclosed, as well as pharmaceutical compositions including the compounds, and methods of using the labeled and unlabeled compounds, and specifically, 2-Amino-5-guanidino-pentanoic acid (3-{4-[3-(2-amino-5-guanidino-pentanoylamino)-propyl]-piperazin-1-yl}-propyl)-amide and metabolites thereof, for imaging, detecting and assessing disorders and diseases, such as arthritis and, more specifically, osteoarthritis by tracking proteoglycan and glycosaminoglycan content of cartilage. Also, pharmaceutical compositions comprising labeled and/or unlabeled 1,4-Bis(3-aminopropyl)piperazine are disclosed and methods of using the same.

Abstract: The present invention provides methods for detecting an enzymatic activity, the method including combining at least one magnetic particle to an enzyme substrate to form a magnetically modified substrate, reacting the magnetically modified substrate with at least one enzyme; and detecting a change in a magnetic property of the magnetically modified substrate or its cleavage products, thereby detecting an activity of said at least one enzyme, wherein the method may be applied to a human subject to detect a disease selected from the group consisting of rheumatitis, arthritis, an injury, Dupuytren's disease, Peyronie's disease, a collagen related disease, steatosis, fibrosis, cirrhosis, metastasis, tissue regeneration, cancer, coronary disease, a liver disease, a metabolic condition, an infection and an inflammatory disease.

Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.

Abstract: Disclosed herein are globular nanostructures having a hydrodynamic diameter (Dh) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (Dc) of 6-90 nm and said peripheral part has an estimated thickness (Tp) so that Dh=Dc+2Tp, wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30% by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30% of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of —COOR1, —P?O(OR1)(OR2), and —S(?O)2OR1, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, a

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.

Abstract: The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension comprising the microsphere or the powder, the use of the microsphere, a method for detecting a tumor, and a therapeutic composition comprising the microsphere, the powder, or the suspension. The invention provides a method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt.

Abstract: The invention relates to a system for treating gases and/or liquids with radiation or for detecting radiation in gases and/or liquids, including at least one optical system and a reactor. The reactor has a hollow body shape which includes lateral surfaces, connecting parts, and an inner chamber which may be open to the front and rear sides, through which a medium flows or in which the medium is present. The reactor is designed, at least partially, in the form of a radiation reflector and is divided into first and second functional areas. This enables a particularly homogeneous radiation distribution in the inner chamber of the reactor, which increases the efficiency of the treatment or detection. Also, due to this arrangement, the system is more compact.

Abstract: A packaging for sterile products, comprising a tray and a hood made from cellular plastic material comprising at least two covering sheets held at a distance from one another by a plurality of spacers having cells longitudinally parallel to each other, the tray and the hood comprising a base and sidewalls cut from a plate of said material and with at least one of said sidewalls having double thickness and being formed by folding two panels of the plate around the folding lines perpendicular to the direction of said spacers. The interior covering sheets are perforated to allow the passage of a sterilizing gas through said covering sheet, the perforations allowing the passage of the gas but preventing the passage of dust, wide cut-outs traversing at least the other covering sheet of the plate in order to ensure communication of said cells with the outside and being provided along the folding lines of said panels.

Abstract: An olfactory display includes a housing and a plurality of fragrance chambers formed in the housing. In each fragrance chamber, a solid-like fragrance source is accommodated and an airflow source is provided to send air into the fragrance chamber from an air intake port. An auxiliary airflow source that emits odorless air is also provided in the housing. The airflow source and the auxiliary airflow source are operated alternately or simultaneously. In response to a user operating an adjustment knob of a controller, operating time periods and stopping time periods of the airflow source and the auxiliary airflow source are changed, or the number of operating times is changed within a predetermined operating time period. A mixing ratio of the fragrance and the odorless air may also be adjusted by changing a voltage value of an alternating voltage to be applied to a piezoelectric device of the airflow source.

Abstract: A chip sanitizing device comprises an area that is substantially enclosed and includes a sanitizing unit comprising a germicidal bulb and a power source. One or more chips is placed within the device and after the germicidal bulb is activated the one or more chips is sanitized. In another embodiment of the invention a chip rack is modified to include a sanitizing unit comprising a germicidal bulb, a power source and a fan stored in a housing attached to the chip rack. The slots are modified to contain openings to allow ultraviolet light to reach the chips sitting atop the rack. The ultraviolet light may sterilize microorganisms such as germs and bacterium found on chips. A fan is used to provide circulation and may increase the likelihood of germs and bacteria coming into contact with the ultraviolet light. In a further embodiment of the invention a lid is provided that substantially covers the chip rack and stores the sanitizing unit.

Abstract: Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are composed of (a) a polyanion in the absence of a polycation, wherein the polyanion comprises at least one crosslinking group capable of covalently crosslinking with itself, and (b) a sufficient amount of a complimentary multivalent cation or multivalent anion to produce the simple coacervate. The adhesives have numerous medical and non-medical applications.

Abstract: One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

Abstract: According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a wound dressing is provided comprising a scaffold coated with a biologically active composition comprising a lipoic acid derivative. In a further embodiment, a system is provided for treating a tissue site of a patient, the system comprising a reduced-pressure source to supply reduced pressure, a manifold to distribute reduced pressure to a tissue site and a scaffold coated with a biologically active composition comprising a lipoic acid derivative. Methods for producing such a system and scaffold are also disclosed.

Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.

Abstract: The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P.

Abstract: The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.

Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.

Abstract: Methods of decellularization of tissue, such as mammalian tissue, through use of cyclical pressure changes are provided, along with methods of making an extracellular matrix (ECM) preparation.

Abstract: The present invention relates to a process for manufacturing an object made of biocompatible hydrogel by molding a polymer solution in a mold made of a particular material, said process comprising the following steps: (i) preparation of a polymer solution by dissolving a copolymer of acrylonitrile and of an olefinically unsaturated co-monomer bearing anionic groups in an aprotic solvent, optionally in the presence of a nonsolvent, (ii) shaping and the start of gelation of the polymer solution obtained at the end of step (i) in a mold consisting of a material containing said nonsolvent or of a material permeable to said nonsolvent, (iii) immersion of the object undergoing gelation resulting from step (ii) in a nonsolvent. The present invention also relates to the objects made of biocompatible hydrogel resulting from this process such as, for example, intracorneal lenses (or lenticules) implantable in the cornea or any other implants usable in ophthalmology.

Abstract: Devices, systems, and methods for treatment of an eye alter aspiration flow from the eye in response to an occlusion of the aspiration conduit pathway. Where aspiration is drawn from the eye using a volumetric pump, the pump can be reversed so as to induce fluid reflux from the aspiration conduit pathway into the eye to help clear the occlusion. The pump may vary the reverse flow in response to sensed aspiration pressure or the like, and the reverse flow may be halted before the pressure within the aspiration conduit pathway adjacent the eye significantly exceeds the irrigation fluid pressure and/or the pressure within the eye. Reflux may alternatively be generated by modulating a vent valve disposed between an irrigation conduit pathway and the aspiration conduit pathway.

Abstract: A tissue removal device includes a rigid aspiration cannula, a valve communicating with the aspiration cannula in a fluid-sealed manner, and a pneumatically-driven actuator configured for moving the valve between an open position and a closed position, wherein at the open position the valve defines an aspiration path through the aspiration cannula and the valve, and at the closed position the valve prevents vacuum from being applied at the distal tip.

Abstract: Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Abstract: A peristaltic pump includes a driver, a pump body, a hose, a rotor and a connecting member. The driver includes a supporting shaft. The pump body includes a chamber housing the rotor. The hose is assembled to an internal side of a wall of the chamber. The connecting member connects the driver with the rotor, and is received in the chamber. The rotor is configured to sequentially squeeze the hose to cause medium in the hose to flow. The connecting member and the rotor rotate about and are supported by the supporting shaft. The medical peristaltic pump has a simple structure and is easy to operate.

Abstract: A device, a kit and a method are presented for permanently augmenting the pump function of the left heart. The basis for the presented innovation is an augmentation of the physiologically up and down movement of the mitral valve during each heart cycle. By means of catheter technique, minimal surgery, or open heart surgery implants are inserted into the left ventricle, the mitral valve annulus, the left atrium and adjacent tissue in order to augment the natural up and down movement of the mitral valve and thereby increasing the left ventricular diastolic filling and the piston effect of the closed mitral valve when moving towards the apex of said heart in systole and/or away from said apex in diastole.

Abstract: A catheter (20), which can be part of an intravascular blood pump, possesses a kink sensor which extends over the total length of the catheter and comprises an optical fiber (28A). The optical fiber is attached to an evaluation device (100) which evaluates a preset light quantity transmitted through the optical fiber as to whether a part of the light quantity is coupled out of the optical fiber along the length of the optical fiber. This is interpreted as a kink event and displayed. The optical fiber preferably utilized for the kink sensor is the optical fiber of an optical pressure sensor.

Abstract: A blood treatment apparatus adapted to preserve a blood treatment unit between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit, ii) fill the blood treatment unit with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit. A related method is also described.

Abstract: A renal therapy apparatus including at least two feedback controls is disclosed. Each control includes an estimated volume calculator to calculate an estimated volume based on a set flow, a comparator to compare the estimated volume with a measured volume, a volume deviation determining means to determine a volume deviation based on the comparison, a correction calculator to calculate a correction based on the volume deviation, a flow control generator to generate a flow control signal based on the calculated correction amount and the set flow, and a feedback control output to output the controlled flow control signal to a pump associated with each feedback control.

Abstract: A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first indwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter. Each connector is equipped with an electrode in contact with the lumen of the connector, the electrodes electrically connected to an electronic circuit that measures the impedance or conductivity of fluid between the first connector and second connectors via a fluid path through the blood vessel, fistula or graft. An electronic controller receives the impedance or conductivity data and processes the data to determine whether a vascular access disconnection has occurred.

Abstract: An apparatus includes a syringe housing and a plunger slidably received within the syringe housing between a first position and a second position. The plunger has a substantially opaque portion and a substantially translucent portion. A light sensor module is disposed on the syringe housing. The light sensor module has a light sensor housing and a first sensor element and a second sensor element. The first sensor element and the second sensor element are disposed within the sensor housing. Positioning the plunger at the first position aligns the substantially translucent portion with the first sensor element and positioning the plunger at the second position aligns the substantially translucent portion with the second sensor element.

Abstract: A clamp assembly for an IV pump, or similar device, is disclosed. Disclosed embodiments include a clamp having a first lever arm with a first clamping end and a second lever arm having a second clamping end. A central axle connects the first lever arm and the second lever arm and allows the first clamping end and the second clamping end to pivot away from and towards each other. A biasing spring biases the first clamping end towards the second clamping end. Also disclosed is a bracket that is connected to the first lever arm and has a pump mounting portion that allows an IV pump, or similar device, to be mounted thereon.

Abstract: Devices and methods are provided for drug delivery. The device may include a housing having a first compartment containing a drug in a dry, solid form, a second compartment containing a liquid carrier for the drug, and an expansion member located within or adjacent to the first or second compartment. The second compartment may be fluidly connectable to the first compartment by a rupturable barrier or mechanical valve. The device may also include an actuation system configured to expand the expansion member to rupture the rupturable barrier or open the mechanical valve and permit the liquid carrier to flow into the first compartment and mix with the drug to form a reconstituted drug solution.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary infusion device includes a motor operable to deliver fluid to a body of a user, a first control module to enable input power for the motor and provide a dosage command for operating the motor, and a second control module coupled to the first control module to receive the dosage command and operate the motor using at least a portion of the input power based at least in part on the dosage command. One of the first control module and the second control module detects an anomalous condition, and in response, disables the input power to the motor, stores diagnostic information for the anomalous condition in its internal memory, and automatically resets thereafter.

Abstract: A device for delivering fluid into the body is provided. The device may comprise a reservoir including at least one wall for retaining fluid and a plunger (400), wherein the plunger is articulated with a drive screw (300) having a distal end (304) that rotates within the plunger and displaces the plunger in a linear direction.

Abstract: A Huber needle assembly with safety capture device includes at least a body, a needle, and a movable arm. The movable arm is pivotable relative to the body, and includes a capture hood at a distal end thereof. The capture hood is cylindrical, includes a perimeter side wall having an outer face and an inner face, and has open proximal end. The capture hood includes a slot through the perimeter side wall, providing access into an internal chamber defined by the perimeter side wall. The slot extends longitudinally over at least a portion of the length of the capture hood, and at least a portion of the slot has a width less than the outside diameter of the needle to capture a tip of the needle therein when the movable arm pivots to a safety-capture position.

Abstract: A system and method for a patch-like, self-contained substance infusion device (700) which can be attached to a skin surface via an adhesive contact surface. A push button (780) activation assembly can then be used to remove an interlock (730), allowing a disk or Belleville spring (735) assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly (710). This allows the release of one or more spring-loaded patient needles (760) into the skin surface, and establishes a fluid communication path between the patient needles (760) and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button (780) activation assembly further allows the release of one or more improved safety mechanisms (794) after use.

Abstract: The invention relates to a safety needle device, particularly for the puncture of a port implanted subcutaneously in a human or animal body, comprising a first housing; a hollow needle, wherein the needle has a first sub-section and a second sub-section, and the first sub-section extends along a puncture axis, which runs at a right angle to the surface of the human or animal body, and the second sub-section of the needle being arranged at a right angle to the first sub-section, substantially parallel to the surface of the human or animal body, wherein the hollow needle is or can be connected to the first housing, particularly in the region of the second sub-section; a cover comprising a through-hole for receiving the first sub-section of the needle, wherein the cover can be moved from a first position into a second position relative to the first housing, wherein the movement occurs substantially along the puncture axis; and an at least partially flexible limiting element for limiting the relative movement bet

Abstract: Disclosed is a fluid dispensing device that includes at least one reservoir to hold the therapeutic fluid, at least one other unit requiring communication with ambient air, at least partly, to operate, and at least one housing defining an interior to retain the at least one reservoir and the at least one other unit. The at least one housing has at least one vent port formed on one or more of its walls. The at least one vent port is adapted to direct or communicate air to maintain pressure equilibrium between the air pressure in the interior of the at least one housing and the ambient air pressure outside the at least one housing, and provide communication with the ambient air to the at least one other unit requiring air to enable operation of the at least one other unit.

Abstract: A drive mechanism having integrated status indication includes a drive housing, a status switch interconnect, a drive biasing member, a piston, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the drive biasing member is configured to bear upon an interface surface of the piston. Drive mechanism may include an incremental status stem having a stem interconnect, wherein the stem resides within the drive housing and the piston, and wherein the stem has an interconnect which engages one or more contacts on the piston to provide incremental feedback. A drug delivery pump with integrated status indication includes a housing and an assembly platform, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection, a power and control system, and the drive mechanism having a drug container may be mounted.

Abstract: An electronic controller for an insulin infusion device includes at least one processor device and at least one memory element that cooperate to provide a processor-implemented closed-loop initiation module. The initiation module is operated to obtain a most recent calibration factor for a continuous glucose sensor, the most recent calibration factor representing a first conversion value applicable to convert a first sensor value to a first blood glucose value. The initiation module also obtains a prior calibration factor for the sensor, and calibration timestamp data for the most recent calibration factor and the prior calibration factor. The initiation module regulates entry into a closed-loop operating mode of the insulin infusion device, based on the most recent calibration factor, the prior calibration factor, and the calibration timestamp data.

Abstract: A reservoir assembly comprising a reservoir housing, a piston, and a locking plug, both movably arranged inside the reservoir housing; wherein the volume between the piston and the locking plug defines a reservoir cavity. The reservoir assembly further comprising a reservoir outlet; and an actuator configured to act on the piston; wherein the locking plug is configured to be movable from a first position to a second position; wherein in the first position the reservoir outlet is not in fluid communication with the reservoir cavity. The reservoir assembly further comprising an interlock configured to prevent movement of at least one of the locking plug and the piston; wherein the interlock having a locked position and an unlocked position.

Abstract: The present invention relates to an assembly line to assemble a medical device and comprising at least one communication member adapted to communicate with a corresponding communication member of an initial component of the device, wherein the assembly line comprises at least one assembly stage adapted to conduct at least one step of assembly being at least influenced by device-related data obtained from the component.

Abstract: A self-lubricating medical syringe is provided for self-lubricating the inner surface of a prefilled syringe barrel. The syringe has a plunger distinguishing a compressible porous cylinder, which can be infused with a lubricant and is sandwiched in between a proximal and distal rubber tip. The self-lubricating medical syringe will be able to compensate for any missing lubricant along the inner surface of the syringe barrel and will also be able to provide for a uniform motion of the plunger.

Abstract: An arrangement comprising an optical element and an indication member for a drug delivery device is provided. The indication member comprises a plurality of indicia. The optical element comprises an imaging section and a light-transmissive non-imaging section, wherein the indication member is movable with respect to the optical element such that the indicia can be successively moved into a display position relative to the optical element. The imaging section is configured such that, when a first indicium is arranged in the display position, the first indicium is imaged by the imaging section into an imaging solid angle. The non-imaging section is configured such that light defining a second indicium is deflected by the non-imaging section such that the second indicium cannot be identified by a user in the imaging solid angle on a viewing side of the optical element.

Abstract: The safety syringe includes a barrel having a clamping slot, a large sealing ring and a zero line; a plunger having a pull pawl and an annular convex clamping disc, an avoiding seams; a rubber plug; a needle connector having annular clamping pawls, an inner sealing ring and a pullback ring; and a locking body made of a polymer material with elasticity and having a sealing disc, a sealing ring, a clamping ring and a checking ring. The sealing disc, large sealing ring, sealing ring and inner sealing ring are engaged to constitute a sealing structure. When the clamping ring meshed with the pull pawl is dragged to retract inwards, the sealing ring and pullback ring are engaged to pull the needle connector to retract, and the checking ring is plugged into the inner cavity of the clamping pawls to fix the clamping pawls in the clamping slot.

Abstract: In an injection device a rotary indicator element (20) indexes angularly between a pre-firing position to an injection complete position to create a visual and audible/tactile signal as the drive plunger (28) arrives at or near its fired position. The indicator element (20) has a saw tooth profile which co-operates with respective abutments (34, 40) on the plunger and a housing part of the device to control and energize indicator movement.

Abstract: The present invention safety device is a one-piece needle assembly that has a base and a housing pivotally connected to the base. The base has a distal portion to which a needle is fitted. At the base there is formed longitudinally along its distal portion a catch mechanism that may be in the form of an anchor projection. At the back wall of the housing there is extended another catch mechanism that may be configured in the form of two clasping fingers. Also providing in the housing is an integral hook. As the housing and the base are pivoted relative to each other, and as the needle makes contact with the hook, the respective catch mechanisms at the base and the housing also make contact with each other, resulting in the coupling of the catch mechanisms and the coupling of the needle to the hook. As a result, the catch mechanisms are interlocked and the needle is fixedly retained by the hook within the housing.

Abstract: The present invention relates to a device comprising at least one fluid reception chamber and at least one hydrophobic filter means, wherein a vertical through the hydrophobic filter means does not have a point of intersection with a fluid level of fluids present in the fluid reception chamber. It further relates to an external functional means as well as a treatment apparatus.