Patents Issued in June 19, 2018
  • Methods of sequencing with linked fragments
    Patent number: 10000799
    Abstract: The invention generally relates to sequencing library preparation methods. In certain embodiments, two template nucleic acids are joined together by a linking molecule, such as a PEG derivative. The linked template nucleic acids is amplified, creating linked amplicons.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 19, 2018
    Assignee: Boreal Genomics, Inc.
    Inventors: Milenko Despotovic, Joel Pel, Andrea Marziali
  • Nucleic acid constructs and methods of use
    Patent number: 10000800
    Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 19, 2018
    Assignee: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
    Patent number: 10000801
    Abstract: This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 19, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Sequencing method
    Patent number: 10000802
    Abstract: Disclosed is a method for determining the sequence of nucleotide bases in a polynucleotide analyte characterised by the steps of: a. generating a stream of droplets at least some of which contain a single nucleotide and wherein the order of single nucleotides in the droplet stream corresponds to the sequence of nucleotides in the analyte; b. introducing into each droplet a plurality of biological probe types each type (i) comprising a different detectable element in an undetectable state and (ii) being adapted to capture a different complimentary single nucleotide from which the analyte is constituted; c. causing the single nucleotide contained in the droplet to bind to its complimentary probe to create a used probe; and d. causing the detectable element to be released from the used probe in a detectable state.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: June 19, 2018
    Assignee: BASE4 INNOVATION LTD
    Inventors: Cameron Alexander Frayling, Barnaby Balmforth, Bruno Flavio Nogueira de Sousa Soares, Thomas Henry Isaac, Boris Breiner, Alessandra Natale, Michele Amasio
  • Polynucleotide mapping and sequencing
    Patent number: 10000803
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 19, 2018
    Assignee: BioNano Genomics, Inc.
    Inventors: Ming Xiao, Han Cao, Parikshit A. Deshpande, Michael Boyce-Jacino
  • Methods of macromolecular analysis using nanochannel arrays
    Patent number: 10000804
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 19, 2018
    Assignee: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • Isolation of polymerase-nucleic acid complexes
    Patent number: 10000805
    Abstract: Compositions, methods and systems are provided for isolating DNA having a modified or unnatural base. Circular DNA fragments, each comprising a double stranded DNA central region and single stranded regions on the ends of the double stranded regions, are obtained. Some of the fragments have one or more modified or unnatural base. The DNA fragments are treated with a primer and a polymerase such that the polymerase extends the primer to copy at least one of the strand of the double stranded region. This results in rendering the other strand single stranded. A binding protein or antibody that is specific to the modified or unnatural base is then used to isolate strands containing the modified or unnatural bases. Methods for loading such complexes onto substrates and for single molecule sequencing of such complexes are also provided.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: June 19, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Thang Pham, Arunashree Bhamidipati, Kevin Travers, Eric Olivares, Tyson A. Clark, Jonas Korlach
  • Triplex event-specific reaction used to quantify specific events and possible contaminating events
    Patent number: 10000806
    Abstract: Disclosed herein are methods for determining if a contaminating integration of a nucleotide sequence is present in a set of nucleic acids. Further disclosed herein are methods for determining the copy number/zygosity of a nucleic acid sequence of interest. The methods disclosed herein may be performed using quantitative PCR.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 19, 2018
    Assignee: Dow AgroSciences LLC
    Inventors: Tina Marie Kaiser, Stephen Novak
  • Materials and methods for identifying gyrase inhibitors
    Patent number: 10000807
    Abstract: The disclosure describes the effects of transcription mediated from a promoter on the transcription mediated by divergently coupled supercoiling-sensitive promoter. Transcription initiated from a promoter inhibits transcription mediated by a specific supercoiling-sensitive promoter that is divergently coupled to the promoter. A gyrase inhibitor relieves this inhibition and substantially increases the transcription mediated by the specific supercoiling-sensitive promoter that is divergently coupled to another promoter. Accordingly, the invention pertains to a method for identifying a compound as a gyrase inhibitor or not a gyrase inhibitor based on differential expression of genes under the control of divergently coupled promoters in the presence of the compound. Another embodiment of the invention provides an assay for identifying one or more compounds from a library of compounds as a gyrase inhibitor.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: June 19, 2018
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Fenfei Leng, Xiaoduo Zhi, Samantha Dages, Kelley Dages
  • Methods of detecting cervical cancer
    Patent number: 10000808
    Abstract: Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are also provided.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: June 19, 2018
    Assignee: Cepheid
    Inventors: Cecilia Svanholm Barrie, Olivier Delfour, David H. Persing
  • Methods for determining risk of chronic lung allograft dysfunction (CLAD) and subtypes thereof
    Patent number: 10000809
    Abstract: Methods for assaying a donor lung for chronic allograft lung dysfunction (CLAD) optionally bronchiolitis obliterans syndrome (BOS) subtype or restrictive allograft syndrome (RAS) subtype of CLAD or risk of developing BOS subtype or RAS subtype CLAD post-transplant, the method comprising: a. measuring a normalized expression level of an RNA transcript of IL-6 or an expression product thereof in a sample of the donor lung pre-transplant or a normalized expression level of one or more S100 protein, optionally S100A8 and/or S100A9, polypeptide expression product in a sample from the donor lung post-transplant; b.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 19, 2018
    Assignee: University Health Network
    Inventors: Shaf Keshavjee, Mingyao Liu, Marcelo Cypel
  • MiRNA fingerprint in the diagnosis of multiple sclerosis
    Patent number: 10000810
    Abstract: The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 19, 2018
    Assignee: Hummingbird Diagnostics GmbH
    Inventors: Andreas Keller, Eckart Meese, Anne Borries, Peer Friedrich Staehler, Markus Beier
  • Markers to predict macrocyclic lactone drug resistance in dirofilaria immitis, the causative agent of heartworm disease
    Patent number: 10000811
    Abstract: Disclosed are nucleic acid molecules from the genome of Dirofilaria spp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species of Dirofilaria is Dirofilaria immitis (the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with a Dirofilaria spp. nematode, and kits for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: June 19, 2018
    Assignee: Elanco US Inc. and McGill University
    Inventors: Roger K. Prichard, Catherine Bourguinat, Timothy G. Geary
  • Treatment of disease
    Patent number: 10000812
    Abstract: The invention relates to the use of angiogenin, or a fragment or variant thereof, to treat diseases or conditions characterized by neuronal injury or death, or axonal degeneration, especially neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). The invention also describes a plurality of mutations of the human angiogenin gene which are associated with a neurodegenerative disease phenotype, and particularly a ALS phenotype. Also described is a method of assessing whether an individual is afflicted with, or generically predisposed to develop, a disease or condition characterized by neuronal injury or death, or axonal degeneration.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: June 19, 2018
    Assignee: Royal College of Surgeons in Ireland
    Inventors: Matt Greenway, Orla Hardiman
  • Method of diagnosing and treating cancer using B-catenin splice variants
    Patent number: 10000813
    Abstract: The invention relates to method and compositions for treating and diagnosing cancer, in particular ?-catenin related cancers. In general, the methods include administering RNAi constructs. The invention further relates to methods of identifying CTNNB1 related cancer therapeutics.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: June 19, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Mark J. Roth, Konrad Huppi
  • ALK and NTRK1 fusion molecules and uses thereof
    Patent number: 10000814
    Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: June 19, 2018
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Doron Lipson, Roman Yelensky
  • Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
    Patent number: 10000815
    Abstract: Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: June 19, 2018
    Assignees: THE GENERAL HOSPITAL CORPORATION, DANA-FARBER CANCER INSTITUTE, INC
    Inventors: Daphne Winifred Bell, Daniel A. Haber, Pasi Antero Janne, Bruce E. Johnson, Thomas J. Lynch, Matthew Meyerson, Juan Guillermo Paez, William R. Sellers, Jeffrey E. Settleman, Raffaella Sordella
  • Method for detecting an increased risk of developing skin cancer and a use of a genotype variant of the GRHL3 gene
    Patent number: 10000816
    Abstract: The present invention is directed to methods of identifying SNP markers associated with skin cancers, and use of these markers to explain individual susceptibility to skin cancer development. In addition, described SNPs have been identified as potentially crucial for proper GRHL3 protein function.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 19, 2018
    Assignee: INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
    Inventors: Agnieszka Kikulska, Tomasz Michal Wilanowski, Piotr Lukasz Rutkowski
  • Mutation detection assay
    Patent number: 10000817
    Abstract: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3? terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3? terminal nucleotide; and b) detecting the presence of said product in said amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: June 19, 2018
    Assignee: EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: Hongzhi Zou, Graham P. Lidgard, Michael J. Domanico, Hatim Allawi
  • Prevention and diagnosis of visceral fat
    Patent number: 10000818
    Abstract: The invention is based on a correlation observed between visceral fat and gut flora. The invention relates to a product increasing the relative proportion of bifidobacteria in the intestines and to be used for preventing formation of visceral fat or for reducing the amount thereof in the body. In particular, the product increases the ratio of bifidobacteria to Clostridia. The invention also relates to determining visceral fat in the body by determining the relative proportion of bifidobacteria or Clostridia or their ratio to each other in the intestines. The invention further relates to a method for estimating, in the same manner, the health risk associated with obesity.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: June 19, 2018
    Assignee: Gut Guide Oy
    Inventors: Annika Mayra-Makinen, Eveliina Munukka
  • Sequences and their use for detection and characterization of O157:H7
    Patent number: 10000819
    Abstract: This invention relates to a rapid method for detection and characterization of Escherichia coli bacteria serotype O157:H7 based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect E. coli O157:H7 in a food or water sample, such as a beef enrichment. The present invention further relates to replication compositions and kits for carrying out the method of the present invention.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: June 19, 2018
    Assignee: Qualicon Diagnostics LLC
    Inventors: Daniel R. Demarco, Mark A. Jensen, Stephen Varkey
  • Genetic loci associated with resistance of soybean to cyst nematode and methods of use
    Patent number: 10000820
    Abstract: Various compositions and methods are provided for identifying and selecting plants with enhanced resistance to soybean cyst nematode (SCN). Further provided are transgenic plants, plant parts, and seed and methods of their use comprising a heterologous polynucleotide operably linked to a promoter active in the plant are provided, as are methods of making such plants and methods of use, wherein said heterologous polynucleotide comprises at least one, or any combination thereof, of Glyma18g2580, Glyma18g2590, Glyma18g2600, Glyma18g2610; and Glyma18g2570 or an active variant or fragment thereof. Expression of the heterologous polynucleotide enhances the resistance of the plant to cyst nematode.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 19, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Bryce Reid Daines, David Hyten, Nichole Lynn Schneider, John Bryan Woodward
  • Direct smelting process
    Patent number: 10000821
    Abstract: A molten bath-based direct smelting process includes controlling the process conditions in a direct smelting vessel so that molten slag in a molten bath of metal and slag in the vessel has a viscosity in a range of 0.5-5 poise in an operating temperature range for the process.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 19, 2018
    Assignee: Tata Steel Limited
    Inventors: Rodney James Dry, Jacques Pilote
  • Method for hardening sheet metal material
    Patent number: 10000822
    Abstract: Methods for hardening a metal sheet material include applying at least one peening stream to the metal sheet material, wherein at least one peening stream is applied, in each case, to a front side of the metal sheet material and a rear side of the metal sheet material, respectively, at least at times simultaneously. In one example, the metal sheet material is a stainless steel material, wherein the at least one peening stream is generated from a peening material in which at least 50% by weight of the peening material has a largest particle diameter of at least 0.8 mm and wherein the metal sheet material has a mean final surface hardness after the application of the at least one peening stream of at least approximately 300 HV.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: June 19, 2018
    Assignee: BLANCO GmbH + Co KG
    Inventor: Markus Schiebol
  • Method and device for partially hardening sheet metal components
    Patent number: 10000823
    Abstract: The invention relates to a method for producing partially-hardened components from steel sheets, in which a component that is cold-formed from a hardenable steel sheet material is heated, in a furnace, to a temperature below the austenitization temperature (<AC3), and a radiating element acts upon the component in sections where said component is to be austenitized (<AC3), this radiating element having a component-side contour that corresponds to the contour of the component in the section to be austenitized. The invention also relates to a device for carrying out said method.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: June 19, 2018
    Assignee: voestalpine Metal Forming GmbH
    Inventors: Dieter Hartmann, Roland Ziegler, Tobias Hägele
  • Material for cold-rolled stainless steel sheet and production method therefor
    Patent number: 10000824
    Abstract: A material for stainless steel cold rolling suitable for producing a cold-rolled stainless steel sheet that has sufficient corrosion resistance and ridging resistance as well as excellent formability and surface properties is provided. The material for stainless steel cold rolling according to the present invention contains, in terms of % by mass, C: 0.007% to 0.05%, Si: 0.02% to 0.50%, Mn: 0.05% to 1.0%, P: 0.04% or less, S: 0.01% or less, Cr: 15.5% to 18.0%, Al: 0.001% to 0.10%, N: 0.01% to 0.06%, and the balance being Fe and unavoidable impurities, wherein the material has a microstructure that includes 10% to 60% of a martensite phase in terms of area fraction, with the remainder being a ferrite phase, and the martensite phase has a hardness of HV500 or less.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: June 19, 2018
    Assignee: JFE STEEL CORPORATION
    Inventors: Masataka Yoshino, Hiroki Ota, Ayako Ta, Yukihiro Matsubara, Akito Mizutani, Mitsuyuki Fujisawa
  • Process, method and plant for recovering scandium
    Patent number: 10000825
    Abstract: The present invention relates to a process, method and plant for recovering scandium and ions containing scandium using an ion exchange resin from a feed stream. The feed stream may be, but is by no means limited to, a leach liquor or leach pulp.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: June 19, 2018
    Assignee: Clean TeQ Pty Ltd
    Inventors: Peter Voight, Nikolai Zontov, John Carr
  • Alpha-beta titanium alloy having improved elevated temperature properties and superplasticity
    Patent number: 10000826
    Abstract: A high strength alpha-beta alloy is provided that has improved high temperature oxidation resistance, high temperature strength and creep resistance, and improved superplasticity. In one form, the alloy comprises about 4.5 wt % to about 5.5 wt % aluminum, about 3.0 wt % to about 5.0 wt % vanadium, about 0.3 wt % to about 1.8 wt % molybdenum, about 0.2 wt % to about 1.2 wt % iron, about 0.12 wt % to about 0.25 wt % oxygen, about 0.10 wt % to about 0.40 wt % silicon, with the balance titanium and incidental impurities, with each being less than about 0.1 wt % and about 0.5 wt %, respectively, in total.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: June 19, 2018
    Assignee: Titanium Metals Corporation
    Inventor: Yoji Kosaka
  • Method of forming a sintered nickel-titanium-rare earth (Ni—Ti—RE) alloy
    Patent number: 10000827
    Abstract: A method of forming a sintered nickel-titanium-rare earth (Ni—Ti-RE) alloy includes adding one or more powders comprising Ni, Ti, and a rare earth constituent to a powder consolidation unit comprising an electrically conductive die and punch connectable to a power supply. The one or more powders are heated at a ramp rate of about 35° C./min or less to a sintering temperature, and pressure is applied to the powders at the sintering temperature, thereby forming a sintered Ni—Ti-RE alloy.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: June 19, 2018
    Assignee: UNIVERSITY OF LIMERICK
    Inventors: Syed Ansar Md. Tofail, James Butler
  • Aluminum alloy having an excellent combination of strength, extrudability and corrosion resistance
    Patent number: 10000828
    Abstract: An aluminum alloy having an excellent combination of strength, extrudability and corrosion resistance may include in weight percent, about 0.01% or less copper; about 0.15% or less iron; about 0.60 to about 0.90% manganese, where manganese and iron are present in the alloy in a Mn:Fe ratio of at least about 6.6; about 0.02% or less nickel; about 0.08 to about 0.30% silicon; about 0.10 to about 0.20% titanium; and about 0.05 to about 0.20% zinc; the balance being aluminum and unavoidable impurities. Extruded articles and other articles may be formed using the alloy. Methods of forming such articles may include homogenizing a billet of the alloy prior to forming the article.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: June 19, 2018
    Assignee: Rio Tinto Alcan International Limited
    Inventors: Nicholas Charles Parson, Raynald Guay, Alexandre Maltais
  • Hot-rolled steel sheet
    Patent number: 10000829
    Abstract: A hot-rolled steel sheet includes a specified chemical composition and includes a steel structure represented by an area ratio of ferrite being 5% to 50%, an area ratio of bainite composed of an aggregate of bainitic ferrite whose grain average misorientation is 0.4° to 3° being 50% to 90%, and a total area ratio of martensite, pearlite, and retained austenite being 5% or less.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: June 19, 2018
    Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Yuri Toda, Masafumi Azuma, Akihiro Uenishi, Genichi Shigesato
  • Method for manufacturing martensite-based precipitation strengthening stainless steel
    Patent number: 10000830
    Abstract: The present invention is to provide a method for manufacturing a martensite-based precipitation strengthening stainless steel, which effectively enables crystal grains to become finer by improving a solution treatment method. The method for manufacturing a martensite-based precipitation strengthening stainless steel containing 0.01 to 0.05 mass % of C, 0.2 mass % or less of Si, 0.4 mass % or less of Mn, 7.5 to 11.0 mass % of Ni, 10.5 to 14.5 mass % of Cr, 1.75 to 2.50 mass % of Mo, 0.9 to 2.0 mass % of Al, less than 0.2 mass % of Ti, and Fe and impurities as a remainder, which is provided by the present invention, includes performing a solid solution treatment at 845 to 895° C. once or more.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 19, 2018
    Assignee: HITACHI METALS, LTD.
    Inventors: Ryutaro Abe, Tomonori Ueno, Eiji Shimohira, Gang Han
  • Highly durable coil spring steel
    Patent number: 10000831
    Abstract: Disclosed are a steel composition and a spring steel comprising the same. The steel composition comprises: an amount of about 0.51 to 0.57% by weight of carbon (C), an amount of about 1.35 to 1.45% by weight of silicon (Si), an amount of about 0.95 to 1.05% by weight of manganese (Mn), an amount of about 0.60 to 0.80% by weight of chromium (Cr), an amount of about 0.25 to 0.35% by weight of copper (Cu), an amount of about 0.05 to 0.15% by weight of vanadium (V), an amount of about 0.25 to 0.35% by weight of nickel (Ni), an amount of about 0.003 to 0.015% by weight of phosphorus (P), an amount of about 0.003 to 0.010% by weight of sulfur (S), and iron (Fe) constituting the remaining balance of the steel composition, all the % by weights are based on the total weight of the steel composition.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: June 19, 2018
    Assignees: Hyundai Motor Company, Hyundai Steel Company
    Inventors: Jeen Woo Park, Sung Chul Cha, Jong Hwi Park, Kyu Ho Lee
  • Duplex stainless steel
    Patent number: 10000832
    Abstract: Provided is duplex stainless steel having high strength, SCC resistance and SSC resistance excellent in a high-temperature chloride environment, and capable of suppressing precipitation of a ? phase. The duplex stainless steel of the present embodiment includes, in mass %, of: C: at most 0.03%; Si: 0.2 to 1%; Mn: more than 5.0% to at most 10%; P: at most 0.040%; S: at most 0.010%; Ni: 4.5 to 8%; sol. Al: at most 0.040%; N: more than 0.2% to at most 0.4%; Cr: 24 to 29%; Mo: 0.5 to less than 1.5%; Cu: 1.5 to 3.5%; W: 0.05 to 0.2%; the balance being Fe and impurities, wherein the duplex stainless steel satisfies Formula (1): Cr+8Ni+Cu+Mo+W/2?65 . . . (1), where a symbol of each element in Formula (1) represents a content of the element (in mass %).
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: June 19, 2018
    Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Hideki Takabe, Hisashi Amaya, Kazuhiro Ogawa
  • Thick, tough, high tensile strength steel plate and production method therefor
    Patent number: 10000833
    Abstract: A thick, high-toughness high-strength steel plate has excellent strength and toughness in the central area through the plate thickness. The thick steel plate has a specific chemical composition and includes a microstructure having, throughout an entire region in the plate thickness direction, an average prior austenite grain size of not more than 50 ?m and a martensite and/or bainite phase area fraction of not less than 80%. A continuously cast slab having the specific chemical composition is heated to 1200° C. to 1350° C., hot worked with a strain rate of not more than 3/s and a cumulative working reduction of not less than 15%, and thereafter hot rolled and heat treated.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 19, 2018
    Assignee: JFE STEEL CORPORATION
    Inventors: Shigeki Kitsuya, Naoki Matsunaga, Katsuyuki Ichimiya, Kazukuni Hase, Shigeru Endo
  • Bulk nickel-chromium-phosphorus glasses bearing niobium and boron exhibiting high strength and/or high thermal stability of the supercooled liquid
    Patent number: 10000834
    Abstract: Ni—Cr—Nb—P—B alloys and metallic glasses are provided, where Nb and B are varied such as to achieve alloys with good glass forming ability that form metallic glasses which may exhibit unexpectedly high strength and/or high thermal stability of the supercooled liquid. Specifically, the alloys of the current disclosure are capable of forming metallic glasses and have critical rod diameters of at least 3 mm, while the metallic glasses exhibit yield strength greater than 2550 MPa and stability of the supercooled liquid of at least 45° C.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: June 19, 2018
    Assignees: Glassimetal Technology, Inc., Apple Inc.
    Inventors: Jong Hyun Na, Maximilien Launey, Danielle Duggins, Oscar Abarca, Marios D. Demetriou, William L. Johnson
  • Cooling method and cooling device for Al alloy manufactured casting
    Patent number: 10000835
    Abstract: A method includes product side showering of showering a first surface (the surface of a product (11) opposite to a feeder head (12)) of an Al alloy casting (10) including the product (11) and the feeder head (12) with mist of cooling liquid, and feeder head side showering of showering a second surface (the surface of the feeder head (12) opposite to the product (11)) of the Al alloy casting (10) with the mist of the cooling liquid. The feeder head side showering starts showering the second surface of the Al alloy casting (10) after a start and before an end of the product side showering to quench and cool the Al alloy casting (10) together with the product side showering.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 19, 2018
    Assignee: MAZDA MOTOR CORPORATION
    Inventors: Tomohide Kubota, Naoaki Yamamoto, Shuichi Hashimoto, Yasuyuki Misawa
  • Low-cost fine-grain weak-texture magnesium alloy sheet and method of manufacturing the same
    Patent number: 10000836
    Abstract: The present invention discloses a Mg—Ca—Zn—Zr magnesium alloy sheet, having the chemical compositions in weight percentage: Ca: 0.5˜1.0%, Zn: 0.4˜1.0%, Zr: 0.5˜1.0%, the remainders being Mg and unavoidable impurities; wherein the magnesium alloy sheet has an average grain size of less than or equal to 10 ?m, an interarea texture strength of less than or equal to 5, an interarea texture strength after annealing at 250˜400° C. of less than or equal to 3, and a limiting drawing ratio at room temperature of more than AZ31; and the grain size thereof is remarkably less than that of AZ31B sheet produced in the same conditions, and the sheet texture is notably weakened.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 19, 2018
    Assignee: Baoshan Iron & Steel Co., Ltd.
    Inventors: Gaofei Liang, Yongjie Zhang, Qi Yang, Gang Wang
  • Methods and apparatus for forming bulk metallic glass parts using an amorphous coated mold to reduce crystallization
    Patent number: 10000837
    Abstract: Embodiments herein relate to methods and apparatuses for casting of BMG-containing parts. The surfaces of the mold that come into contact with the molten amorphous alloy comprise an amorphous material. In accordance with the disclosure, the mold may be coated with an amorphous material, e.g., to reduce, minimize, or eliminate crystallization of the molded BMG-containing part. The surfaces of the mold are coated, in certain aspects, so as to reduce or eliminate potential grain-boundary nucleation sites for BMG crystallization. The amorphous material may be selected based on the particular molten amorphous alloy to be cast, e.g., based on the wetting properties, the melting and cooling properties, etc.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: June 19, 2018
    Assignee: Apple Inc.
    Inventors: Douglas J. Weber, Kazuya Takagi, Theodore A. Waniuk
  • Titanium alloys exhibiting resistance to impact or shock loading
    Patent number: 10000838
    Abstract: Titanium alloys formed into a part or component used in applications where a key design criterion is the energy absorbed during deformation of the part when exposed to impact, explosive blast, and/or other forms of shock loading is described. The titanium alloys generally comprise a titanium base with added amounts of aluminum, an isomorphous beta stabilizing element such as vanadium, a eutectoid beta stabilizing element such as silicon and iron, and incidental impurities. The titanium alloys exhibit up to 70% or more improvement in ductility and up to a 16% improvement in ballistic impact resistance over a Ti-6Al-4V alloy, as well as absorbing up to 50% more energy than the Ti-6Al-4V alloy in Charpy impact tests. A method of forming a part that incorporates the titanium alloys and uses a combination of recycled materials and new materials is also described.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: June 19, 2018
    Assignee: Titanium Metals Corporation
    Inventors: Roger Thomas, Yoji Kosaka, Steven James, Paul Garratt
  • Thermal spray composition and component made therewith
    Patent number: 10000839
    Abstract: Thermal spray coating compositions, methods of using thermal spray coating compositions, and remanufactured components are disclosed herein. A thermal spray coating composition can include about 7% to about 9% by weight aluminum, about 5% to about 7% by weight silicon, about 1% to about 3% by weight manganese, about 1% to about 14% by weight copper, with a remaining balance of iron. The thermal spray coating composition can include about 2% to about 12% by weight copper.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: June 19, 2018
    Assignee: Caterpillar Inc.
    Inventor: Daniel Sordelet
  • Piston ring for internal combustion engines
    Patent number: 10000840
    Abstract: The invention relates to a piston ring which is produced from a carrier material, especially steel or a cast material. The piston ring has a wear-resistant coating from a periodic multilayer system, every periodicity consisting of at least two individual metal nitride layers. The multilayer system has superlattice structures, the thickness of an individual layer being ?2 nm to <15 nm and the thickness of the multilayer system being >4.5 ?m and adjacent individual layers within the periodicity having different metallic elements.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: June 19, 2018
    Assignee: Federal-Mogul Burscheid GmbH
    Inventors: Manfred Fischer, Ralf Lammers, Christiane Bauer, Steffen Hoppe
  • Hydrophilic-hydrophobic transformable composite film and the method of fabricating the same
    Patent number: 10000841
    Abstract: A hydrophilic-hydrophobic transformable composite film is disclosed, which has an iron-containing substrate; a silicon-containing layer formed on the iron-containing substrate; and a titanium oxide layer formed on the silicon-containing layer. The hydrophilic-hydrophobic transformable composite film uses UV-light to switch its hydrophilic and hydrophobic property. Also, a method of fabricating the above composite film is disclosed. According to the present invention, an anatase oxide layer can be obtained from the sol-gel techniques, in which the particle size of the titanium dioxide is controlled and a modified surface coating with evident photo-catalyticity is achieved.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: June 19, 2018
    Assignees: Tatung University, Tatung Company, Metal Industries Research & Development Centre
    Inventors: Tair-I Wu, Chien-Lung Huang
  • Oxide sintered body, sputtering target, and oxide semiconductor thin film obtained using sputtering target
    Patent number: 10000842
    Abstract: Provided is an oxide sintered body that, when used to obtain an oxide semiconductor thin film by sputtering, can achieve a low carrier concentration and a high carrier mobility. Also provided is a sputtering target using the oxide sintered body. The oxide sintered body contains, as oxides, indium, gallium, and at least one positive divalent element selected from the group consisting of nickel, cobalt, calcium, strontium, and lead. The gallium content, in terms of the atomic ratio Ga/(In+Ga), is from 0.20 to 0.45, and the positive divalent element content, in terms of the atomic ratio M/(In+Ga+M), is from 0.0001 to 0.05. The amorphous oxide semiconductor thin film, which is formed using the oxide sintered body as a sputtering target, can achieve a carrier concentration of less than 3.0×1018 cm?3 and a carrier mobility of at least 10 cm2V?1 sec?1.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: June 19, 2018
    Assignee: SUMITOMO METAL MINING CO., LTD.
    Inventors: Tokuyuki Nakayama, Eiichiro Nishimura, Fumihiko Matsumura, Masashi Iwara
  • Coating process for non-conductive substrates and devices made from the coating process
    Patent number: 10000843
    Abstract: A method for manufacturing a surgical implant. A metal layer is deposited onto a polyaryletherketone (PAEK) substrate by generating a series of pulses using a high power impulse magnetron sputtering process. Each pulse is applied in a series of micro pulse steps comprising (i) micro pulse on steps ranging from 10 ?s to 100 ?s and (ii) micro pulse off steps ranging from 5 ?s as to 400 ?s; at a repetition frequency ranging from 50-2000 Hz with 2 micropulses to 20 micropulses per repetition, a total pulse on time ranging from 25 ?s to 800 ?s for 5 minutes to 300 minutes at averaged power ranging from 200 W to 3000 W. The series of pulses are performed in a unipolar mode or a bipolar mode.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 19, 2018
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Paul Barker, Jörg Patscheider, Götz Thorwarth
  • Magnetic field generator, magnetron cathode and spattering apparatus
    Patent number: 10000844
    Abstract: A magnetic field generator arranged behind a target and for generating a magnetic field on a front surface of the target based on magnetic force lines can include a ring-shaped outer magnetic body having a pole axis in a parallel direction (X-direction) with respect to the target surface, a center magnetic body arranged on an inner side of the outer magnetic body and having a pole axis in a parallel direction (X-direction) with the direction of the pole axis of the outer magnetic body, a yoke plate for supporting the outer magnetic body and the center magnetic body from behind, and a magnetic permeable plate for changing a magnetic field distribution of the front surface of the target. The magnetic permeable plate is arranged so as to be supported by the yoke plate from behind.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 19, 2018
    Assignees: SHINCRON CO., LTD., UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Wei Kong, Zijing Lin, Ming Li, Bin Xie, Haiqian Wang, Yousong Jiang, Ekishu Nagae
  • MOCVD system for growth of III-nitride and other semiconductors
    Patent number: 10000845
    Abstract: An MOCVD system for growing a semiconductor layer on a substrate is provided. The MOCVD system includes an MOCVD growth chamber defined by a jacket having an interior surface and an exterior surface; a water flow chamber surrounding an exterior surface of the jacket of the MOCVD growth chamber; an electronic control system, wherein the electronic control system facilitates pulsed growth of the semiconductor layer; a supply tube comprising a head formed from a hollow structure defining a fitting end and an opposite, shower end, wherein the fitting end has an initial diameter that is less than a diameter at the shower end; and a susceptor configured to hold the substrate and facing the shower end of the supply tube, wherein the MOCVD system operates at a temperature greater than or equal to 1500° C.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: June 19, 2018
    Assignee: University of South Carolina
    Inventor: Asif Khan
  • Method for producing a tribologically distressed laminate, a laminate and use of an organometallic compound for producing a functional layer of the laminate
    Patent number: 10000846
    Abstract: A method for producing a laminate that has to undergo frictional loads, including a substrate and a functional layer formed from tungsten-containing, amorphous diamond-like carbon. To be able to produce such functional layers easily, they are applied by means of a tungsten-containing precursor and by using a PACVD process. A laminate including a functional layer produced by means of a precursor and to the use of a metallo-organic compound as a precursor for producing a functional layer.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: June 19, 2018
    Assignee: Schaeffler Technologies GmbH & Co. KG.
    Inventors: Andreas Schneider, Yashar Musayev, Tim Matthias Hosenfeldt
  • Graphite susceptor
    Patent number: 10000847
    Abstract: Embodiments described herein include a susceptor for semiconductor processing including an oriented graphite plate that may have a thickness of at least 1 mm. The susceptor may have a support member, and the oriented graphite plate may be disposed on the support member. The support member may have a center thermal conduit and an edge thermal conduit, and may be substantially solid between the center thermal conduit and the edge thermal conduit.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: June 19, 2018
    Assignee: APPLIED MATERIALS, INC.
    Inventors: Preetham Rao, Subramani Iyer, Kartik Shah, Mehran Behdjat
  • Method and use of a binder for providing a metallic coat covering a surface
    Patent number: 10000848
    Abstract: A method for providing a metallic coat covering a surface is disclosed, which comprises: (i) applying an electrically conductive two component binder on said surface; (ii) electrostatic spraying a metal powder on the binder applied in step (i); wherein the metal powder comprises metal particles with an average diameter less than 80 micron.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: June 19, 2018
    Assignee: DE HELLER DESIGN B.V.
    Inventors: Robert Alexander Jonker, Arnoldus Gijsbertus Wilhelmus Van Andel