Abstract: A method of folding and unfolding an active accommodating intraocular lens system includes folding an active lens element along at least one folding line. The at least one folding line is defined by mechanical indentations disposed on a perimeter of the active lens element, and a first pair of the mechanical indentations define terminal ends of a first folding line extending between the first pair of the mechanical indentations. The active lens element is unfolded.

Abstract: A device includes an annular, elastic band having a rectangular cross section. A foil band is affixed to a surface of the elastic band. A contiguous fabric sheath is configured to encase the elastic band and foil band.

Abstract: A prosthetic heart valve includes a frame having a plurality of strut members, an inflow end, and an outflow end. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering has a first layer and a second layer, wherein the second layer has a plush surface. The first layer is folded over a circumferential edge portion of the second layer to form a protective portion that extends beyond the strut members in a direction along a longitudinal axis of the prosthetic heart valve.

Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a non-sewn mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with apertures located within the leaflet attachment region of a leaflet. Some embodiments are further directed toward pulmonary valved conduits incorporating such leaflet and leaflet frame constructs. Methods of making and using such prosthetic valve devices are also described amongst others.

Abstract: A two-step delivery method, system and device is disclosed comprising, in various embodiments, a self-expanding frame. A self-expanding frame is delivered and expanded within a heart chamber followed by delivery of a prosthetic valve comprising prosthetic valves thereon into the expanded self-expanding frame, which is in turn connected to a valve connection region defined on and by the delivered and expanded frame.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: The present invention relates to a delivery apparatus for delivering a radially self-expanding medical device (2) having a proximal portion and a distal portion, said delivery apparatus comprising an elongated tubular member having a proximal end, a distal end and a lumen (122) extending along a longitudinal axis from the proximal end to the distal end; a sheath (11), said sheath (11) being coaxially disposed around the elongated tubular member (12); wherein the elongated tubular member (12) is movable relative to the sheath (11); and wherein the sheath (11) is configured for receiving the radially self-expanding medical device (2) in a radially compressed state; and a holding and retrieving mechanism configured to constrain radially the proximal portion of the radially self-expanding medical device (2) such that in response to a proximal movement of the elongated tubular member (12) relative to the sheath (11), the holding and retrieving mechanism (13) constrains radially the proximal portion of the radially

Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.

Abstract: A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves introducing a chordae tendineae capturing device into a ventricle of a heart, the chordae tendineae capturing device comprising a central hub component and a plurality of spokes, extending the plurality of spokes outward from the central hub component, rotating the chordae tendineae capturing device in a first direction to bring at least one of the plurality of spokes into physical contact with one or more cords of chordae tendineae disposed in the ventricle, further rotating the chordae tendineae capturing device in the first direction to bring the one or more cords inward towards the central hub component, and closing the plurality of spokes at least partially over the one or more cords to secure the one or more cords.

Abstract: Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a first section having a generally spiral shape and a second section connected to the first section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the first section and positioning the second section on an opposite side of the heart valve. The first section may be turned in a manner such that the chords move closer to the center of the first section. The first section draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing.

Abstract: Embodiments relate generally to channel implants used for surgical reconstruction and/or repair. Certain embodiments of the channel implants are designed for craniofacial surgery, reconstruction, and/or augmentation. More specifically, some embodiments find particular use in orbital reconstructive surgery, such as repair of the orbital floor or supraorbital ridge (brow ridge). Embodiments also relate to methods for using and for manufacturing the channel implants disclosed.

Abstract: An artificial cartilage was invented based on JOINT-ELECTRICITY THEORY that first in the world created in 2010, and verified in 2011, both by the present inventor, Sue-May Kang. The said artificial cartilage has sleek joint-surface and individualized appropriate shape, is made of proper piezoelectric material, and to be placed into the indication-joints, including at least the natural joints with lack or defect in cartilage and artificial joints, those suffering from impairment in generating Joint-Electricity. After surgical placement (yet, any surgery is not included in the present invention), it can be subjected to the dynamic force within the said joint in its effective range, and thus, continuously generate intra-articular electricity (is the so-called Joint-Electricity), and consequently supplements the wanted Joint-Electricity to the said joint and its related muscles.

Abstract: According to one example, a tibial replacement assembly for a knee arthroplasty can be configured to couple to a resected proximal surface of a tibia of a human knee. The tibial replacement assembly can include a tibial tray and a first spike. The tibial tray can include a proximal surface and a distal surface opposing the proximal surface. The distal surface can be configured to be disposed on a resected proximal surface of a tibia. The first spike can be removably secured to the tibial tray and can extend generally distally away from the distal surface. The first spike can be configured to extend beneath the resected proximal surface of the tibia.

Abstract: The present invention relates to an asymmetric artificial knee joint that includes a bearing member having a medial sulcus and a lateral sulcus, and a femoral component having a medial condyle and a lateral condyle and disposed on the bearing member.

Abstract: A total knee replacement prosthesis assembly (10) comprising a femoral component (20), a tibial component (30) having a tibial platform (32), and a bearing component (40), the bearing component having an inferior side (40b) and a superior side (40a), the bearing component being adapted to be arranged between the femoral component and tibial platform when assembled, the tibial platform having a post (36) upstanding from it and the bearing component having a post recess (46) in its inferior side for receiving the post, the bearing component being rotatable about the post when assembled, the post and bearing component each having a transverse bore and the assembly further comprising an axle (60), at least part of the axle being received through the transverse bore (38) in the post when assembled and at least part of the axle being received through the transverse bore (52) in the bearing component when assembled, the axle being configured to provide an axis of rotation between the femoral component and bearing co

Abstract: A stand-alone expandable interbody spinal fusion device including a superior component, an inferior component, an expansion mechanism arranged to displace the superior component in a first direction relative to the inferior component, and a self-piercing screw mechanism arranged within the superior component or inferior component. When torque is applied to the expansion mechanism, torque is transferred 90 degrees thereby displacing a threaded rod or toothed shaft in a first direction thereby displacing the superior component in a first direction relative to the inferior component. When torque is applied to the self-piercing screw mechanism, torque is transferred 90 degrees thereby displacing a self-piercing screw body in a first direction to engage an anchor layer and the bone material of vertebrae thereby holding the interbody spinal fusion device it in place within a disc space.

Abstract: The present invention relates to an intervertebral disc prosthesis comprising at least three pieces including an upper plate, a lower plate, and a movable core at least in relation to a plate, wherein it also comprises at least one elongated movable osseous anchor comprising an insertion end disposed at a first longitudinal end of the anchor and a retention end disposed at a second longitudinal end of the anchor and a plate-like body disposed between the insertion end and the retention end.

Abstract: An expandable intervertebral implant is provided for insertion into an intervertebral space defined by adjacent vertebrae. The expandable intervertebral implant includes a pair of outer sleeve portions and an inner core disposed between the outer sleeve portions. Movement of the inner core relative to the outer sleeve portions causes the outers sleeve portions to deflect away from each other, thereby engaging the expandable intervertebral implant with the vertebrae and adjusting the height of the intervertebral space.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: An expandable interbody implant adapted for insertion at least into a disc space, between two adjacent vertebrae of a spine. An upper member and a lower member are pivotally connected at least by a drive link. A bone graft storage portion packed with a selected volume of bone growth material. A translational wall is provided between the bone graft storage portion and a trailing end of the implant. An actuator engages the bone graft storage portion, pushing it forward into engagement with the drive link, which pivots upward, moving the upper member upward away from the lower member. Upward movement of the upper member raises the translational wall to a position to assist in retention of the selected volume bone graft material within the hollow portion of the bone graft storage portion. Upward rotation of the drive link brings a face thereof into contact with a front of the bone graft storage portion, thereby retaining near constant volume of the bone graft material.

Abstract: Disc degeneration and chronic back pain are caused by a transport hindrance of oxygen, nutrients and pH buffer from capillaries in endplates into mid-layer of the intervertebral disc. A fluid absorbing conduit is inserted into the intervertebral disc, drawing and delivering the oxygen, nutrients and pH buffer in fluid of body circulation from capillaries at endplates into the mid-layer of the disc. The disc undergoes thousands of relaxation and compression cycles each day from daily activity of the patient. During relaxation phase, the fluid of body circulation containing oxygen, nutrients, and pH buffer is infused into the fluid absorbing conduit. During compression phase, the oxygen, nutrients, and pH buffer in the fluid absorbing conduit is dispersed into the mid-layer of the disc. The pH buffer, bicarbonate, neutralizes the lactic acid to relieve the discogenic pain. Oxygen inhibits hypoxic inflammation and production of lactic acid to further reduce the discogenic pain.

Abstract: A prosthetic hand includes a main frame, a hold unit and a drive unit. The hold unit includes a first finger, and a second finger. The first finger has a first proximal end portion, and a first distal end portion opposite to the first proximal end portion. The drive unit includes a drive mechanism and a first transmission mechanism. The first transmission mechanism is coupled to the drive mechanism and the first finger. The drive mechanism drives the first transmission mechanism to rotate the first finger about a first axis between a first closed position and a first open position, and to rotate the first finger about a second axis transverse to the first axis between the first open position and an eversion position.

Abstract: A device is provided to allow adaptation of a prosthetic or robotic foot in the medial-lateral direction, including pronation and supination of the foot using a series of articulations. Articulations are permitted in the disclosed device due to linkage systems positioned at various locations of the prosthetic foot. In particular, the device includes multiple connected linkage systems each including upper and lower portions with an articulating contact surface designed for load carriage and stability. The point of contact between the contact surfaces of each linkage system comprises the position-dependent instantaneous center of rotation of the upper portion with respect to the lower portion. The device also includes a platform coupled between the linkage systems and a base.

Abstract: An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device.

Abstract: A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.

Abstract: Medical devices including vascular access kits and related system and methods are disclosed. In some embodiments, a vascular access system may include a first conduit, a second conduit, and an expandable stent that is coupled to both the first and second conduits such that there is a continuous lumen between the first conduit and the second conduit. Methods of deploying the vascular access system within the body of a mammal, more particularly, a human patient are disclosed. Methods of bypassing a section of vasculature of a mammal, more particularly, a human patient are disclosed. The vascular access system, when implanted and assembled, may be a fully subcutaneous surgical implant.

Abstract: Described is an apparatus for transcatheter detachment of a stent from a delivery device. A single-ended draw line with loops is inserted through a restraining hole in a glide and a release line is inserted through the loops. The single-ended draw line is thus prevented from pulling through the restraining hole while the release line is through the loops. The single-ended draw line is free to pass through the restraining hole after the release line is pulled out of the loops and thereafter pulled free of stent holes formed through a stent, thereby detaching the stent at a desired location.

Abstract: A delivery system includes an elongated shaft component, a self-expanding valve prosthesis, at least one cinching suture, and a radially-expandable sleeve. The valve prosthesis is disposed over a distal portion of the elongated shaft component and includes a compressed configuration for delivery and an expanded configuration for deployment. The at least one cinching suture removably couples the valve prosthesis to the elongated shaft component and radially compresses the valve prosthesis into the compressed configuration for delivery. The sleeve is secured to and encircles an outer surface of the valve prosthesis. The sleeve has a delivery state with a first diameter extending over a full length of the valve prosthesis in the compressed configuration and a deployed state with a greater second diameter extending over the full length of the valve prosthesis in the expanded configuration. The sleeve is configured to prevent paravalvular leakage in situ in the deployed state.

Abstract: Devices for delivering and deploying an endoluminal prosthesis are disclosed and comprise a delivery catheter, an endoluminal prosthesis disposed at a distal end portion of the delivery catheter, and a wire. The prosthesis comprises a tubular graft having at least one fenestration. The wire extends distally from a first wire end through an axial lumen of the delivery catheter and the prosthesis, and through the fenestration in the graft. The wire extends proximally through a lumen of the prosthesis and through an axial lumen of the delivery catheter towards a second wire end. Additional devices, systems, and methods are disclosed.

Abstract: A delivery system for delivering an implantable stented device to a lumen of a patient, the delivery system including an elongated body having a proximal end and a distal end, a driver mechanism positioned at the proximal end of the elongated body, an elongated threaded rod located axially distal to the driver mechanism, and a sheath including an elongated tubular portion having a hollow interior portion with a first diameter that is sized for compression and retention of the implantable stented device in a compressed configuration for delivery to a body lumen.

Abstract: A device that is inserted through the abdominal wall and into the digestive tract of a human is disclosed. The device may be placed through a method such as percutaneous endoscopic gastrostomy (PEG). The device includes a gastrostomy style structure that provides fluid communication with the external environment of the patient with the internal contents of the stomach. The device is produced with a series of slotted collection channels that preferentially, when connected to a source of negative relative pressure, directs a significant volume of the high calorie fluidic components of the chyme out of the digestive tract, preventing exposure to the absorptive tissues of the digestive tract when simple sugars and carbohydrates are consumed.

Abstract: A system for supporting and manipulating a leg of a patient, the system including a base configured to be releasably secured to the ground, a first elongate guide rail coupled to the base, wherein the first elongate guide rail has a longitudinal axis, a boot moveably coupled to the first elongate guide rail, wherein the boot is configured to receive and retain at least a portion of a foot of the patient, a drape hanger assembly coupled to the base and configured to support a drape, wherein the drape hanger assembly includes a pair of drape hangers oriented parallel to the longitudinal axis of the first elongate guide rail, wherein the pair of drape hangers are disposed on opposite sides of the first elongate guide rail in top view, and a drape attached to each drape hanger and positioned between the boot and the first elongate guide rail.

Abstract: A protective shield having a tubular shape is used for protecting a wound on a limb of an animal. The protective shield includes a first sleeve half, a second sleeve half, and a hinge connecting the first and second sleeve halves for enabling the protective shield to move between open and closed positions. A first splint overlies the inner surface of said first sleeve half, and a first splint attachment strip is secured to the inner surface of the first sleeve half and extends between upper and lower ends of the first sleeve half. The first splint attachment strip has a plurality of splint mounting positions provided thereon for enabling the first splint to be secured to the first sleeve half at different locations between the upper and lower ends of the first sleeve half. A second splint overlies the inner surface of the second sleeve half, and a second splint attachment strip is secured to the inner surface of the second sleeve half and extends between upper and lower ends of the second sleeve half.

Abstract: A rehabilitation aid for use by persons having a need for a sling. The rehabilitation aid can be incorporated into an article of clothing and have a sleeve positioned beneath an arm of a user. The sleeve can be configured to support at least a portion of the weight of the arm and help to substantially immobilize, constrain, or restrict the movement of the upper arm. An adjustable attachment can be included to adjust arm angle. Reinforcements can also be incorporated to help distribute supported weight throughout the article of clothing.

Abstract: An arm support for use in a medical procedure, comprises an arm support strap and a hand support. The arm support strap comprises a first end that is configured to pass around the arm of a patient and secure to a region of the arm support strap, a support region for supporting an arm of the patient, and a second end configured to pass across the torso of the patient to be secured so as to support the arm securely against a side of the torso in a position substantially co-planar with the torso. The hand support comprises a first region adapted to secure the hand support to the arm support strap, and a second region adapted to engage with a hand of the patient for securing an associated forearm of the patient in a supinated, externally rotated position. The support is for use in radial access procedures, securing the patient's wrist in a dorsiflexed position.

Abstract: A stomal irrigation support device including an irrigation sleeve support and a waste receptacle stop is provided. The irrigation sleeve support can have a structural configuration to support an irrigation sleeve and to extend across a portion of a user's body and onto a waste receptacle during use. The waste receptacle stop can be coupled to the irrigation sleeve support and can be positioned to impede movement of the irrigation sleeve support toward the waste receptacle during use.

Abstract: An apparatus for providing breathing assistance includes a body for positioning within an oral cavity of a user, the body defining at least one first opening for allowing airflow between lips of the user. Two second openings are provided in the oral cavity to allow air flow into and out of a posterior region thereof. Two channels each connect a respective second opening to the at least one first opening. Each channel passes at least one of at least partially along the buccal cavity and at least partially between the teeth to thereby provide an airway at least partially bypassing the nasal passage to act to replicate a healthy nasal passage and pharyngeal space. A tongue retaining portion includes a cavity for receiving a portion of a tongue, the tongue retaining portion configured to retain the tongue in an extended position to project at least partially between the teeth.

Abstract: Disclosed is a mandibular advancement device including a first frame, a second frame, a first rib on the first frame, the first rib extending generally from a front side of the first frame to a back side of the first frame, a first upstanding sidewall facing the first rib, a first channel on the second frame, the first channel in relative position to interface with the first rib, and an opening of the first channel, the opening of the first channel having a width that is narrower than a width of the first rib.

Abstract: Provided is a soft flexible oral appliance having protuberances that mimic naturally occurring dental Tori. An upper, palatial appliance and a lower, mandibular appliance may be used in conjunction or separately to alleviate a variety of disorders, improve facial tone, and increase physical performance. The appliances are lightweight, thin, and do not prohibit normal speech patterns when in use Small protuberances are strategically molded along key surfaces of each appliance to stimulate nerves in the tongue and affect forward protrusion. Forward positioning of the tongue dilates the airways of the throat improving breathing while the use is sleeping, playing sports, or talking. It also reduces bruxing or grinding of the teeth. A method is further provided, for adding protuberances to other types of oral appliances, thereby conferring some of the benefits listed above on appliances originally intended for other dental uses.

Abstract: A process and an apparatus for loading, insertion and placement of an intrauterine contraceptive device (IUD) for its proper and hygienic placement in the uterus, the apparatus in a sterile pouch having a transparent cover and a base; the apparatus having a loader with a passage having a first opening and a second opening running along its elongated body, a graduated tube mounted onto loader through its second opening, an IUD and a push rod miming inside the graduated tube. The IUD is parked in the loader in an expanded condition, required to maintain inside the uterus. The loader has a guide means forming the front portion of the loader and pusher means forming rear portion of the loader. A platform connects the guide means and the pusher means of the loader. The passage runs along an elongated body of the loader.

Abstract: The present disclosure includes devices, systems and related methods useable for controlling a patient's body temperature by endovascular heat exchange as well as body surface heat exchange.

Abstract: A controlled temperature therapy system has a pump, a reservoir, and a therapy component. The reservoir has an inlet in communication with the therapy component and an outlet in communication with the pump. The reservoir may also include a baffle adjacent the outlet.

Abstract: A conformal thermal device is described that can conform to one or more body parts of a user for either warming or cooling the body parts to within a desired or therapeutic temperature range. Some embodiments of the conformal thermal device include features that indicate a cooling and/or heating temperature. In addition, some embodiments of the conformal thermal device include modular extensions for adapting the shape of the conformal thermal device to a part of the body. Various other features and functions associated with the conformal thermal device are described herein.

Abstract: Example heat exchange pads are described herein. A heat exchange pad can include an input compartment, an output compartment arranged in fluid connection with the input compartment, and an internal member disposed between the input and output compartments. The internal member can include an array of holes formed therein. Additionally, the internal member can be configured to produce impinging flow convection heat transfer in proximity to a heat exchange surface of the output compartment.

Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.

Abstract: The methods and apparatus disclosed herein can be used to treat glaucoma of the eye. The methods and apparatus can be configured to apply energy to the sclera, cornea, and/or other regions of the eye in order to shrink collagenous tissue near Schlemm's canal. Juxtacanalicular treatment of the sclera and/or cornea adjacent Schlemm's canal can be used to dilate Schlemm's canal, collector channels, and/or the Trabecular Meshwork. The methods and apparatus can be configured to apply energy to the sclera to generate scleral vacuoles in the sclera to improve uveoscleral outflow.