Patents Issued in July 26, 2018
  • Publication number: 20180207080
    Abstract: The invention relates to the use of specific fluorosurfactants for increasing the efficacy of antioxidants, in particular in cosmetic, dermatological preparations and medicinal products, and to specific mixtures and preparations
    Type: Application
    Filed: June 16, 2016
    Publication date: July 26, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Manuela LOCH, Reiner FRIEDRICH
  • Publication number: 20180207081
    Abstract: Provided is a gelled composition that exhibits, despite having 50 mass % or more of a polyhydric alcohol content, a strong thickening effect, while providing a smooth feeling of use on the skin, and even excellent dispersibility. The gelled composition of the present invention contains (A) a polymer of an ethylenically unsaturated carboxylic acid monomer crosslinked with a water-soluble crosslinking agent, (B) a polyhydric alcohol, and (C) water, wherein component (A) is present in an amount of 0.1 to 5 mass %, component (B) is present in an amount of 50 to 95 mass %, and component (C) is present in an amount of 1 to 10 mass %.
    Type: Application
    Filed: August 1, 2016
    Publication date: July 26, 2018
    Applicant: SUMITOMO SEIKA CHEMICALS CO., LTD.
    Inventors: Akio NAKATSUKA, Makiko KAWANO, Yousuke NAKAMURA
  • Publication number: 20180207082
    Abstract: The present invention provides: an aqueous hair care composition comprising; a. 0.5 to 3 w.t. of cationic polymer, b. one or more hair benefit agents, wherein the composition is substantially free of fatty materials, and wherein the benefit agent is selected from glycerine and silicone.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 26, 2018
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventor: Stephen Leonard BRIGGS
  • Publication number: 20180207083
    Abstract: The present invention provides a hair treatment composition comprising; a. 40-99 w.t. % of a dispersion of a loosely reticulated silicone elastomer solvent; b. a compound selected from; i. 0.005-8 w.t % temporary dye ii. 0.005-12 w.t. % semi-permanent dye iii. 0.001-6 w.t. % pigment and mixtures thereof, c. 0.005 w.t. % to 59 w.t.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 26, 2018
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Aikaterini BOUA, Lalitesh CHANDRA
  • Publication number: 20180207084
    Abstract: The present invention relates to a nail care system containing (1) at least one composition containing at least one adhesive agent, at least one primary film former and at least one plasticizer; and (2) an applicator.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 26, 2018
    Applicant: L'ORÉAL
    Inventors: Ruisong XU, Aline Aude GUIMONT, Allen SHA, Ramakrishnan HARIHARAN, Chaitrali Makarand GOTHE, Christopher John TARLING
  • Publication number: 20180207085
    Abstract: Cosmetic composition for healing and treating the skin, the formula of which consists exclusively of compounds functional for the skin and/or compounds functional both for the skin and also for the structure of the formula.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 26, 2018
    Inventor: Raffaella Gregoris
  • Publication number: 20180207086
    Abstract: The present invention relates to an emollient composition comprising emu oil, jojoba oil, a dermatological base and a metal or metalloid oxide, hydroxide or carbonate. The composition has efficacy in the prevention or treatment of a range of skin conditions.
    Type: Application
    Filed: August 4, 2016
    Publication date: July 26, 2018
    Applicant: EUPHARMA PTY LTD.
    Inventor: Alec EUTICK
  • Publication number: 20180207087
    Abstract: A kit and an aesthetic system for the prevention of skin aging includes a telomerase activating composition, a skin dermis irradiating laser, a composition for topical fat removal including a hyaluronidase, and a skin muscle layer irradiating laser, as well as a process for preventing skin aging in humans using said kit and system. The kit and aesthetic system for the prevention of skin aging have comprehensive effects concerning skin aging including instantaneous wrinkle improvement, skin contouring, elasticity enhancement, wrinkle improvement, topical fat removal, and skin hydration improvement as well as long-lasting maintenance effects up to 1 year to 1.5 years, despite their short treatment time.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Inventor: Youna Son
  • Publication number: 20180207088
    Abstract: This invention is a natural face cream/lotion that exploits the benefits of Dead Sea salt for helping moisturize the skin of a human face. The lotion consists of natural ingredients such as organic aloe vera juice, shea butter, preferably unrefined, emulsified wax, Dead Sea salt, hydrolyzed wheat protein, essential oils (particularly lavender, rosehip seed oil and carrot seed oil), apple cider vinegar, and xanthan gum. They are included with a preservative made from leuconostoc/radish root ferment filtrate and phenoxyethanol.
    Type: Application
    Filed: February 9, 2018
    Publication date: July 26, 2018
    Inventor: Noha N. Hakim
  • Publication number: 20180207089
    Abstract: The present invention relates to compositions forming a low viscosity mixture of: i) a non-polymeric slow-release matrix ii) at least one biocompatible, (preferably oxygen containing) organic solvent; iii) at least one peptide active agent; and iv) at least one lipid soluble acid. The invention further relates to methods of treatment comprising administration of such compositions, especially in treating diabetes, and to pre-filled administration devices and kits containing the formulations.
    Type: Application
    Filed: October 26, 2017
    Publication date: July 26, 2018
    Applicant: CAMURUS AB
    Inventors: Catalin NISTOR, Markus JOHNSSON, Fredrik TIBERG
  • Publication number: 20180207090
    Abstract: Described is an intra-mammary teat sealant and a corresponding method of forming a physical barrier in the teat canal of a non-human animal for prophylactic treatment of mammary disorders during the animal's dry period. The method includes the step of infusing a teat seal formulation including a metal salt in a glyceride-containing gel base into the teat canal of the animal. The method also prevents the formation of black spot defect in dairy products, especially cheddar cheese, made from the milk of animals so treated.
    Type: Application
    Filed: March 21, 2018
    Publication date: July 26, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Scott A. Rankin
  • Publication number: 20180207091
    Abstract: The invention is directed to delivering therapeutic agents to the eye for the purpose of treating ophthalmic disorders, diseases and injuries. In particular, the invention is directed to delivering therapeutic agents to the eye for the purpose of treating ophthalmic disorders, diseases and injuries by targeted intranasal administration of the therapeutic agents. The invention is specifically directed to treating disorders, diseases and injuries of the cornea and ocular surface, treating retinal disorders, diseases and injuries and optic nerve disorders, diseases and injuries by targeted intranasal administration of the therapeutic agents.
    Type: Application
    Filed: March 21, 2018
    Publication date: July 26, 2018
    Applicant: Noveome Biotherapeutics, Inc.
    Inventor: Larry R. Brown
  • Publication number: 20180207092
    Abstract: The invention is directed to a method for preventing nasolacrimal duct obstruction (NLDO) in a patient receiving high dose radioactive iodine for treatment of cancer. The method includes administering an effective amount of perchlorate anion to the eyes of the patient.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Applicant: KEM PATENT HOLDINGS, LLC
    Inventor: Kenneth Eli Morgenstern
  • Publication number: 20180207093
    Abstract: The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.
    Type: Application
    Filed: May 29, 2016
    Publication date: July 26, 2018
    Applicants: The Texas A&M University System, Th Board of Regents of the University of Texas System
    Inventors: Carolyn L. Cannon, Parth N. Shah, Justin A. Smolen, Hugh D. Smyth, Ashkan K. Yazdi, Matthew J. Herpin
  • Publication number: 20180207094
    Abstract: A topical formulation comprising an oil-in-water (o/w) emulsion of ketoprofen in a racemic or (s)-enantiomer form is provided herein. In some embodiments, the topical formulation is a cream. In some embodiments, the topical formulation includes one or more oily substances, higher alcohols, drug solubilizing vehicles, surfactants, permeation enhancers, buffering agents, antioxidants, preservatives, and water.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 26, 2018
    Inventors: Samir Roy, Charlotte P. Clark
  • Publication number: 20180207095
    Abstract: Described herein is a cell tissue gel containing collagen and hyaluronan at a weight ratio of 0.01-100:1.
    Type: Application
    Filed: March 26, 2018
    Publication date: July 26, 2018
    Inventor: Lynn L.H. Huang
  • Publication number: 20180207096
    Abstract: A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.
    Type: Application
    Filed: July 22, 2016
    Publication date: July 26, 2018
    Inventors: Gaelle Corne, Damien Lenoble, Jean-Sebastien Thomann
  • Publication number: 20180207097
    Abstract: A non-toxic vehicle for hormone therapy. The non-toxic vehicle includes a cationic lipid or a neutral lipid and polyethylene glycol.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 26, 2018
    Applicant: Government of the United States as Represented by the Secretary of the Air Force
    Inventors: Thomas Shaak, Suizhao Wang
  • Publication number: 20180207098
    Abstract: A composition for use in the treatment of fistula, the composition comprising activated carbon.
    Type: Application
    Filed: April 11, 2018
    Publication date: July 26, 2018
    Inventors: Soren Halskov, Mats Ekelund
  • Publication number: 20180207099
    Abstract: New non-mechanical process of micronization, capable to reduce the particle size of digoxin from ordinary level to a selected micrometer range. Micronization is obtained via a specific treatment, to be performed on a purified and concentrated digoxin solution in an organic solvent. The purified and concentrated digoxin solution is obtainable via a sequence of solvent treatments; then, after reaching the required concentration, the solution is further concentrated, obtaining the precipitation of digoxin; the reaction mixture is then added with methanol under stirring for a suitable time. The recovered precipitate consists in a digoxin with particle size comprised between 20 and 30 micrometers for at least 90% by weight of the obtained particles, and is exempt from degradation products.
    Type: Application
    Filed: July 21, 2016
    Publication date: July 26, 2018
    Inventor: Raman MEHTA
  • Publication number: 20180207100
    Abstract: The present invention relates to solid dosage forms of palbociclib comprising a water-soluble acid. The dosage forms described herein have desirable pharmacokinetic characteristics.
    Type: Application
    Filed: May 24, 2016
    Publication date: July 26, 2018
    Applicant: PFIZER INC.
    Inventors: Fady Makram Louiz Ibrahim, Matthew Patrick Mullarney, Ravi M. Shanker, Barbara Rodriguez Spong, Jian Wang
  • Publication number: 20180207101
    Abstract: The present invention relates to premixes for the production of active compound-containing tablets which comprise polyvinyl alcohols (PVAs). The invention also relates to active compound-containing tablets which comprise a corresponding premix.
    Type: Application
    Filed: July 3, 2015
    Publication date: July 26, 2018
    Applicant: Merck Patent GmbH
    Inventors: Roberto OGNIBENE, Finn BAUER, Thorsten WEDEL, Guenter MODDELMOG
  • Publication number: 20180207102
    Abstract: The present invention relates to a complex containing celecoxib and tramadol. The present invention is designed such that, even though two different active ingredients are prepared into a single dosage form, the release patterns of respective drugs are optimized in the expression of synergy effects, with respect to pain, of the respective drugs, through the new prescription.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 26, 2018
    Inventors: Jung Ju KIM, Dong Min LEE, Sun Kyoung KIM
  • Publication number: 20180207103
    Abstract: In one form of the invention, there is provided a method for treating osteoarthritis, the method comprising applying a broad spectrum antimicrobial formulation to the subchondral bone of a mammal. In another form of the invention, there is provided a pharmaceutical composition for treating infections, including infections leading to arthritis.
    Type: Application
    Filed: March 22, 2018
    Publication date: July 26, 2018
    Inventors: Bruce E. Reidenberg, Robert DiLuccio
  • Publication number: 20180207104
    Abstract: Nanopaiticle compositions described herein comprise combinations of prodrugs of therapeutic agents that achieve enhanced therapeutic effects as compared to those observed when combinations of free forms of these therapeutic agents are administered.
    Type: Application
    Filed: July 14, 2016
    Publication date: July 26, 2018
    Applicant: CELATOR PHARMACEUTICALS, INC.
    Inventors: Leon WAN, Winnie LUI, Paul TARDI, Lawrence MAYER
  • Publication number: 20180207105
    Abstract: A method of manufacturing a therapeutic agent for the treatment of infections includes the steps of preparing a homogeneous solution of poly(DL-lactide-co-glycolide acid), preparing a solution of a peroxygen donor, preparing a solution of an acetyl donor, adding each of the solutions to a quantity of the poly(DL-lactide-co-glycolide acid) solution to produce a resultant mixture, preparing encapsulated nano- or micro-scale particles from the resultant mixture using a microencapsulator, collecting the nano- or micro-scale particles, and subsequently subjecting the particles to a lyophilization process.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 26, 2018
    Inventor: Adrian Neville FELLOWS
  • Publication number: 20180207106
    Abstract: The invention relates generally to the field of nanoparticles, and more specifically, in one embodiment, to bio-nanoparticle elements formed from materials comprised of self-assembling protein molecules, which are capable of coating one or more type of elements. In another invention embodiment, the invention relates to a protein that coats one or more elements in order to modify or improve one or more characteristic of the element, including, but not limited to, stability, rigidity, or functionality of the element that is coated with the instant invention.
    Type: Application
    Filed: February 26, 2018
    Publication date: July 26, 2018
    Inventors: Franco Vitaliano, Gordana Dragan Vitaliano
  • Publication number: 20180207107
    Abstract: Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering ?-Klotho (?Klotho) protein or DNA to a subject.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 26, 2018
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Connie HSIA, Yi HONG, Orson W. MOE, Kytai NGUYEN
  • Publication number: 20180207108
    Abstract: The present invention provides a method for manufacturing a patch comprising a backing and an adhesive layer laminated on the backing, comprising: a step of mixing an acid addition salt of asenapine, a (meth)acrylic acid ester (co)polymer and a desalting agent to obtain an adhesive composition; and a step of shaping the adhesive composition to obtain the adhesive layer.
    Type: Application
    Filed: July 21, 2016
    Publication date: July 26, 2018
    Inventors: Atsushi SONOBE, Takashi YASUKOCHI
  • Publication number: 20180207109
    Abstract: The present invention relates to the use of multiple doses of Cladribine combined with beta interferon for the treatment of multiple sclerosis in patients who are refractory to at least one conventional therapy.
    Type: Application
    Filed: March 22, 2018
    Publication date: July 26, 2018
    Inventors: H. JAMES BRENTZEL, Jr., MARIA LOPEZ-BRESNAHAN, NAZIH AMMOURY
  • Publication number: 20180207110
    Abstract: The presently claimed and disclosed invention(s) provides a therapeutically effective composition and method of inhibiting nerve cell transmission. In a preferred embodiment of the presently claimed and disclosed invention(s), the treatment of neuropathic pain utilizing terpene compounds isolated from plant essential oils or manufactured synthetically is detailed. These compounds, such as geraniol and citronellol, as well as chemical analogs thereof, used in combination or individually, can be used alone or in a composition with a pharmaceutically acceptable carrier in a suitable dosage form.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 26, 2018
    Inventors: Alexander McLellan, Frank Greenway
  • Publication number: 20180207111
    Abstract: Methods for increasing susceptibility of cancer cells to immunotherapeutic agents and methods for assessing the effectiveness of a cancer treatment.
    Type: Application
    Filed: July 22, 2015
    Publication date: July 26, 2018
    Inventor: Carmen DE TORRES GÓMEZ-PALLETE
  • Publication number: 20180207112
    Abstract: The present invention provides compositions and methods of their use in treating dystroglycanopathy, muscular dystrophy and other disorders.
    Type: Application
    Filed: January 25, 2018
    Publication date: July 26, 2018
    Inventors: Qi Long Lu, Bo Wu
  • Publication number: 20180207113
    Abstract: An in vivo intracellular reprogramming method for both somatic and stem cell pools in the mammal's body using, C60 fullerenes can be added to enhance mitochondrial ATP production and Biogenesis, Metformin, Everolimus, Seligilene, Danasitab, Venetoclaxalong with Quercitin may act as agent to enhance autophagy and apoptosis helping to decrease their ongoing formation and a novel resveratrol complex along ribonucleasies worth together to help decrease heterchromation dysregulation aid in DNA repair enhancement and nutraceuticals is disclosed. The present in vivo reprogramming invention works at the epigenetic level and promotor region of the genome inside the nucleus of the cell, and other intracellular organelles, rather than outside the body.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 26, 2018
    Inventor: Vincent C Giampapa
  • Publication number: 20180207114
    Abstract: Brown adipose tissue (BAT) plays a role in keeping an organism warm in response to a cold environment. In response to cold, transcription factors, including peroxisome proliferator receptor alpha (PGC1?), mediate the adaptive changes in the expression of oxidative and thermogenic genes in BAT. However, even without cold, BAT exhibits high expression of these genes relative to white adipose tissue (WAT). It is shown herein that estrogen related receptor gamma (ERR?) is a critical factor that controls the expression of key metabolic genes in BAT under basal conditions. ERR? is highly expressed in BAT versus WAT, yet is not transcriptionally induced by cold, suggesting it plays an important role in innate basal BAT function rather than in the adaptive response to cold. Based on these observations, methods of increasing thermogenesis in a subject by administering a therapeutically effective amount of one or more agents that increase ERR? activity are provided.
    Type: Application
    Filed: March 21, 2018
    Publication date: July 26, 2018
    Applicant: Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Ruth T. Yu, Maryam Ahmadian
  • Publication number: 20180207115
    Abstract: Provided is a means effective in treating dermatomycosis. An external therapeutic agent for treating dermatomycosis containing a trialkali metal salt of citric acid.
    Type: Application
    Filed: June 20, 2016
    Publication date: July 26, 2018
    Inventor: Shiro Yoshizaki
  • Publication number: 20180207116
    Abstract: Methods of quantifying N2-carboxyethyl-2?-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 26, 2018
    Inventors: Samuel Rahbar, Timothy W. Synold, John Termini
  • Publication number: 20180207117
    Abstract: Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Kenneth C. Cundy, Srikonda Sastry, Manshiu Leung, Balaji V. Kadri, Paul E. Stach
  • Publication number: 20180207118
    Abstract: This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 26, 2018
    Inventors: Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
  • Publication number: 20180207119
    Abstract: This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 26, 2018
    Inventors: Michael Hamill, Raffi Afeyan, William Comb
  • Publication number: 20180207120
    Abstract: A composition comprising azelaic acid as an active ingredient suppresses accumulation of lipids in adipose tissue and improves lipid metabolism in adipose tissue.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 26, 2018
    Inventors: Sung-Joon Lee, Chunyan Wu
  • Publication number: 20180207121
    Abstract: This invention relates to compositions and methods for the therapy and diagnosis of neurodegenerative or neuromuscular disorders. More particularly, this invention relates to use of anaplerotic agents for treating, preventing, or delaying the onset of a neurodegenerative or neuromuscular disorder.
    Type: Application
    Filed: November 29, 2017
    Publication date: July 26, 2018
    Inventors: Karin BORGES, Shyuan T. NGO
  • Publication number: 20180207122
    Abstract: Methods of delaying the onset of an infection or preventing an infection caused by a microbial organism in an internal cavity of a subject are provided. Methods of killing or inactivating microorganisms in at least a portion of the urethra of a subject are provided.
    Type: Application
    Filed: March 20, 2018
    Publication date: July 26, 2018
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Matthew T. Scholz, Terry R. Hobbs, DanLi Wang
  • Publication number: 20180207123
    Abstract: The invention provides a compound of formula (I): (I) wherein R1-R4 have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer).
    Type: Application
    Filed: July 19, 2016
    Publication date: July 26, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Richard Lutz, Eric Andrianasolo, Paul Falkowski, Eileen White, Liti Haramaty
  • Publication number: 20180207124
    Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)—wherein R7 is a hydrogen atom, a (C1-C6) alkyl group and the like, or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Applicant: PITNEY PHARMACEUTICALS PTY LIMITED
    Inventors: Nobuharu ANDOH, Osamu SANPEI, Tetsuo TOGA, David MORRIS, Roger ASTON, Koji TANAKA, Tomokazu HINO
  • Publication number: 20180207125
    Abstract: The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Inventors: Carl E. Wagner, Pamela A. Marshall, Peter W. Jurutka
  • Publication number: 20180207126
    Abstract: The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Inventors: Carl E. Wagner, Pamela A. Marshall, Peter W. Jurutka
  • Publication number: 20180207127
    Abstract: The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the ?-amyloid protein (A?) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of A? in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered.
    Type: Application
    Filed: June 21, 2017
    Publication date: July 26, 2018
    Inventors: Hong-Lin SU, Chia-Yu CHANG, Shiaw-Min HWANG, Huai-En LU, Horng-Jyh HARN, Shinn-Zong LIN, Ping-Shan LAI
  • Publication number: 20180207128
    Abstract: The present invention concerns a dosage form, preferably for immediate release, comprising siponimod, a moisture-protective-agent and further pharmaceutical excipients and methods for producing said dosage form.
    Type: Application
    Filed: March 20, 2018
    Publication date: July 26, 2018
    Inventors: Philippe Michel Rene Bouillot, Emeric Reynaud
  • Publication number: 20180207129
    Abstract: Derivatives of licofelone for the treatment of chronic inflammatory diseases and epithelial cancers associated with chronic inflammation are disclosed. The agents target mPGES-1 and 5-LOX.
    Type: Application
    Filed: July 13, 2016
    Publication date: July 26, 2018
    Inventors: Chinthalapally V. Rao, Naveena B. Janakiram, Hariprasad Gali, Alaf Mohammed, Gopal Pathuri