Patents Issued in August 2, 2018
  • Publication number: 20180217110
    Abstract: Systems, methods, and media for detecting abnormalities in equipment that emit ultrasonic energy into a solid medium during failure are provided. In some embodiments, devices for monitoring a piece of equipment are provided, the devices comprising: a piezo microphone having a signal output; a mechanical structure acoustically coupling the piezo microphone to the piece of equipment; a hardware processor configured to: receive intensity signals based on the signal output of the piezo microphone; perform a fast Fourier transform on the received intensity signals to produce a set of output band values for each of a plurality of frequency bands; average at least some of the output band values to produce an average value; and calculate a sum of at least some of the output band values; and a transceiver that transmits the sum to a remote device.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Inventors: Peter Owens, David Micallef
  • Publication number: 20180217111
    Abstract: A method for analyzing a sample can include obtaining an exclusion list of retention time and mass-to-charge ranges corresponding to high abundance compounds within a sample; separating components of the sample using the chromatographic column; obtaining a first mass data set using the mass analyzer while excluding ions within retention time and mass-to-charge ranges of the exclusion list; generating an inclusion list of features of the first mass data set; fragmenting ions corresponding to features of the inclusion list; obtaining a second mass data set from the fragmented ions; and identifying and/or quantifying low abundance compounds based on the second mass data set.
    Type: Application
    Filed: January 31, 2017
    Publication date: August 2, 2018
    Inventors: Iman MOHTASHEMI, Timothy STRATTON, Michael A. BLANK
  • Publication number: 20180217112
    Abstract: A method for evaluating a degree of transformation ratio of kerogen to oil and/or gas and/or gas to oil generation index using a pyrolysis gas chromatography is disclosed. The method comprises providing a rock sample in powdered form; determining, by a source rock analysis instrument, total organic carbon in said rock sample, remaining hydrocarbon generation potential in rock sample, and a maturity of rock sample; feeding said sample in a pyrolyzer if said sample satisfies a pre-defined condition; analyzing, said sample in said pyrolyzer, by heating said sample at a pre-specified pyrolysis temperature in pre-specified pyrolysis steps and for pre-specified pyrolysis time; determining, by a gas chromatograph, a peak area of hydrocarbons present in said sample analyzed; evaluating, in a said degree of transformation ratio of said sample to oil and/or gas and/or said gas to oil generation index.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicant: OIL INDIA LIMITED
    Inventor: Neeraj MATHUR
  • Publication number: 20180217113
    Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Applicant: Ajinomoto Co., Inc.
    Inventors: Masashi Harada, Sachise Karakawa, Kazutaka Shimbo, Naoyuki Yamada
  • Publication number: 20180217114
    Abstract: A purpose of the present invention is to provide a temperature history indicator that allows for visual confirmation of whether the temperature is at or below a prescribed temperature as well as simple conversion of this information into data. A temperature history indicator according to the present invention is characterized by being provided with a label layer and a temperature-indicating layer laminated above or below the label layer, wherein the temperature-indicating layer includes a substance having at crystallization starting temperature of 10° C. or lower and a melting point at least 20° C. higher than the crystallization starting temperature.
    Type: Application
    Filed: July 22, 2016
    Publication date: August 2, 2018
    Inventors: Sukekazu ARATANI, Hiroshi SASAKI, Toyotaka YUASA, Kohhei AIDA, Yasuhiko TADA, Masahiro KAWASAKI
  • Publication number: 20180217115
    Abstract: An analyte sensing probe for attachment to a ferromagnetic surface, the probe comprising a flexible collector plate for placing against the surface, the collector plate having a hole in communication with one end of a capillary and defining when placed against the surface a gap through which air may flow from the periphery of the plate to the capillary, the air entraining any analyte passing through the surface for measurement by an instrument connected in use to the capillary, wherein, in order to cause the collector plate to conform to the surface, the probe further comprises a flexible magnetic assembly positioned on the side of the collector plate remote from the surface, the assembly being composed of a plurality of mutually articulated segments of which at least some are magnetically attracted to the surface.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 2, 2018
    Inventors: William Francis DEAN, Andrew WITTY, Matthew BRADY, Aki LAAKSO
  • Publication number: 20180217116
    Abstract: A gas detector is tested by releasing detectable gas from a storage medium and delivering it to the gas detector. A cartridge for delivering detectable gas includes a container with an outlet and a storage medium in the container. Detectable gas is stored in the storage medium for being desorbed from the storage medium. A test device can include a receptacle for receiving the cartridge, an interface for fluidly coupling the device to a gas detector, and passaging to provide fluid communication between the interface and both the cartridge received in the receptacle and external air. A pump can pump external air and the detectable gas released from the cartridge through the passaging and interface such that the pumped detectable gas and air form a proportioned mixture for testing the gas detector.
    Type: Application
    Filed: February 2, 2018
    Publication date: August 2, 2018
    Applicant: Ideal Labs Research Laboratories, LLC
    Inventors: Ferrel D. Moore, James Robert Moore
  • Publication number: 20180217117
    Abstract: A device includes an upper metallic layer, a lower layer, and a nano sensor array positioned between the upper and lower layers to detect a presence of a gas, a chemical, or a biological object, wherein each sensor's electrical characteristic changes when encountering the gas, chemical or biological object.
    Type: Application
    Filed: March 14, 2018
    Publication date: August 2, 2018
    Inventor: Bao Tran
  • Publication number: 20180217118
    Abstract: An average spoilage temperature for a product is obtained. The average spoilage temperature is the temperature when the product becomes not viable for customer use. In real-time, the current temperature of the retail store in which the product resides is measured. In real-time, a perishability time for the product is calculated using the average spoilage temperature of the product, and the current temperature of the retail store. In real-time, the location of the product and the time since the product has left a first shelf are tracked. The first shelf is a location where a shelf temperature is maintained to adequately preserve the product. In real-time, the perishability time is compared to the time since the product has left the first shelf. When the time since the product has left the first shelf exceeds the perishability time, an action is taken.
    Type: Application
    Filed: January 3, 2018
    Publication date: August 2, 2018
    Inventors: Michael L. Payne, Joshua R. Freeman, Jacob A. Jones, Winston E. D. Spencer
  • Publication number: 20180217119
    Abstract: Disclosed is an enhancement of a carbon sequestration process and method for calculating the quantity of atmospheric carbon sequestration manifested by enhanced oceanic photosynthetic productivity through the process of Iron fertilization. This method and process comprises (1) defining a project boundary, (2) obtaining certain baseline measurements, metrics and observations within and beyond the project boundary, (3) applying an Iron compound within the project boundary to enhance photosynthesis, (4) obtaining certain measurements, metrics and observations within and adjacent to the project boundary prior to and after the introduction of Iron compound and last, (5) applying a method based on the measurements from steps 2 and 4 to determine the net quantity of atmospheric carbon that is sequestered.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Inventor: Peter GROSS
  • Publication number: 20180217120
    Abstract: The delivery of fuel oil through a fuel oil delivery pipe is monitored to measure the flow rate, temperature, viscosity, density and dielectric constant of the fuel oil as it moves through the delivery pipe. The digital data signals from the sensors which are a function of the measured parameters are recorded in a memory. An IR sensor detects the presence of air in the pipe and prevents the data signals from being recorded. The actual total quantity of fuel oil delivered through the pipe is calculated based upon the recorded data signals, which may be adjusted to take into account the temperature of the fuel oil being delivered. A clock circuit generates a timing signal reflecting the date and time the measurements were taken. Information as to the quantity delivered and the time of delivery may be sent to a remote location.
    Type: Application
    Filed: March 8, 2018
    Publication date: August 2, 2018
    Inventor: GREG HABER
  • Publication number: 20180217121
    Abstract: A method for determining a mixing ratio A of n organic, miscible components in a mixture of the components. The method includes the following steps: i) preparing n components in pre-defined quantities, where n is an integer ?2; ii) mixing a respective inorganic marker with one of the respective components in a pre-defined mixing ratio for each of the respective inorganic markers to the respective component, at least one component being mixed with one inorganic marker, and the inorganic markers being of different chemical natures; iii) producing a mixture of the components; (iv) performing an analysis for the quantitative determination of the quantities of the inorganic markers; and v) determining the mixing ratio A of the n components from the defined quantities of the inorganic markers by means of the pre-defined mixing ratios for each of the respective inorganic markers to the respective component.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 2, 2018
    Inventors: Daniel LAESSIG, Ines NIKOLEIZIG, Florian HESSING
  • Publication number: 20180217122
    Abstract: A system for molecular mapping includes a semiconductor substrate defining a reservoir to receive a sample of molecules and a nanofluidic channel in fluid communication with the reservoir. The system also includes a plurality of electrodes, in electrical communication with the nanofluidic channel, to electrophoretically trap the sample of molecules in the nanofluidic channel. At least one avalanche photodiode is fabricated in the semiconductor substrate and disposed within an optical near-field of the nanofluidic channel to detect fluorescence emission from at least one molecule in the sample of molecules.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Inventors: Huaiyu Meng, Rajeev Ram
  • Publication number: 20180217123
    Abstract: To slow down the speed of a biopolymer passing through a nanopore during electrophoresis to such a speed that enables a monomer sequence analysis to be performed. A biopolymer analysis device includes two tanks 101a and 101b each capable of storing a solution containing a biopolymer and an electrolyte, a pair of electrodes 105a and 105b, a thin film 104 with a nanopore, and a three-dimensional structure 103 disposed on the thin film. The three-dimensional structure has a void that can store a solution, and the void forms a flow channel, the flow channel being adapted to allow the solution to pass therethrough from the nanopore to a portion above the three-dimensional structure, and having on its surface a functional group capable of adsorbing the biopolymer. Thus, when a voltage is applied, the three-dimensional structure is not re-dispersed in the solution at least in the range of a hemisphere having the nanopore as the center and having a biopolymer trapping length r as the radius.
    Type: Application
    Filed: July 6, 2015
    Publication date: August 2, 2018
    Inventors: Yusuke GOTO, Takanobu HAGA
  • Publication number: 20180217124
    Abstract: The invention features a method for a model for a determination of an evolution of a level of kidney function over time in a cat. The invention also features a method of assessing an effectiveness of a treatment protocol for affecting kidney function in a cat.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Inventor: Patrick J. Casey
  • Publication number: 20180217125
    Abstract: A method for assessing the quality of a blood product sample, comprises determining in said sample the value of the markers of at least one marker panel of the invention, comparing the values determined with corresponding references, and assessing the quality of said blood sample.
    Type: Application
    Filed: March 26, 2015
    Publication date: August 2, 2018
    Inventors: Beate Kamlage, Oliver Schmitz
  • Publication number: 20180217126
    Abstract: An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. A method for calibrating a flux analyzer is provided which uses an artificial standard rather than a biological standard.
    Type: Application
    Filed: January 31, 2017
    Publication date: August 2, 2018
    Inventor: Andrew C. Neilson
  • Publication number: 20180217127
    Abstract: In the various illustrative embodiments herein, test devices are described with opposing sensor arrays and same side contacts.
    Type: Application
    Filed: July 25, 2016
    Publication date: August 2, 2018
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jennifer A. Samproni, Todd Andrade, Marlene Shi
  • Publication number: 20180217128
    Abstract: The present invention provides means for evaluating harmfulness of a chemical substance before occurrence of cell death, that is, more quickly and sensitively compared to conventional methods wherein the remaining viable cell count is determined using a reductive coloring reagent after a period of time required for occurrence of cell death due to the chemical substance. A double-stranded RNA probe comprising an RNA strand labeled with a fluorescent dye A that emits fluorescence, and an RNA strand labeled with a fluorescent dye B that quenches emission from a fluorescent dye in the vicinity thereof, wherein the fluorescence is quenched in a double-stranded state due to occurrence of fluorescence resonance energy transfer (FRET) between the two kinds of fluorescent dyes.
    Type: Application
    Filed: July 6, 2016
    Publication date: August 2, 2018
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hidenori TANI, Masaki TORIMURA, Hiroaki SATO
  • Publication number: 20180217129
    Abstract: The present invention provides methods of assessing protein modification status and identifying biomarkers linked to cell signaling pathways. The invention provides a method of creating a dataset of modification sites, comprising grouping modification sites on modified peptides from a first sample which has been treated with a first modulator of a protein modifying enzyme and modification sites on modified peptides from a second sample which has been treated with a second modulator of the same protein modifying enzyme into a single group, according to the effect of said first and second modulators of said protein modifying enzyme on said modification sites, wherein said first and second modulators of said protein modifying enzyme are different. The invention further provides a method of preparing a database, methods of treatment and methods of diagnosis.
    Type: Application
    Filed: June 3, 2016
    Publication date: August 2, 2018
    Applicant: Queen Mary University of London
    Inventors: Pedro Rodriguez Cutillas, Edmund Wilkes
  • Publication number: 20180217130
    Abstract: The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NF?B and/or the amount of I?B. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NF?B and/or the amount of I?B is materially unaltered.
    Type: Application
    Filed: January 16, 2018
    Publication date: August 2, 2018
    Inventors: Rongzhen Lu, James Barsoum, Yumiko Wada
  • Publication number: 20180217131
    Abstract: The present invention relates to cell-based assays involving the estrogen receptor and/or aromatase. The assays use assay cells that are transfected with linear cassettes containing the ESR1 or the CYP19A1 gene of interest and measure the effect of mutations on the activity of the estrogen receptor and/or aromatase, and on their response to inhibitors.
    Type: Application
    Filed: January 27, 2017
    Publication date: August 2, 2018
    Applicant: Medical Diagnostic Laboratories, LLC
    Inventor: Yick Loi Raymond Yu
  • Publication number: 20180217132
    Abstract: A measurement method includes a measurement step of measuring a first single value and a second signal value, the first signal value being based on a reaction between a first reacting substance and the sample, the second signal value being based on a reaction between a second reacting substance and the sample, the first reacting substance having a higher reactivity to a second detection target than to a first detection target, the second reacting substance having a higher reactivity to the first detection target than to the second detection target.
    Type: Application
    Filed: May 31, 2016
    Publication date: August 2, 2018
    Applicant: KYOCERA CORPORATION
    Inventors: Kyosuke KISHIMOTO, Hideharu KURIOKA, Atsuomi FUKUURA
  • Publication number: 20180217133
    Abstract: The process of aging and the development of age-related diseases are related to the emerging phenotypes of increasingly damaged and progressively malfunctioning proteomes. The present invention provides methods of preventing aging and age-related diseases in mammals by assessment of protein-specific oxidative damage. Methods of providing treatments that reduce intracellular reactive oxygen and/or nitrogen species, or protein-specific damage caused by reactive oxygen and/or nitrogen species, are disclosed. Furthermore, methods of screening for compounds that reduce intracellular reactive oxidative species, and/or molecules that prevent protein-specific damage by protecting the susceptible protein from such damage and therefore prevent or treat degenerative or age-related diseases, are also disclosed.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 2, 2018
    Inventors: Miroslav Radman, Anita Krisko
  • Publication number: 20180217134
    Abstract: A sensor system that employs sub-pixel sized beads for assays is disclosed. The sensor system includes a first plurality of sensor pixels that define a first active sensor area. The first active sensor area is configured to receive a first portion of a fluid sample. The first portion is mixed with a plurality of first functionalized beads for performing a first assay. The sensor system also includes at least a second plurality of sensor pixels that define a second active sensor area. The second active sensor area is configured to receive a second portion of the fluid sample. The second portion is mixed with a second plurality of functionalized beads for performing a second assay. The first assay and the second assay may be configured to detect different concentration ranges of an analyte in the fluid sample.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Inventors: Ronald B. Koo, Henry Grage
  • Publication number: 20180217135
    Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Applicant: Abbott Point of Care Inc.
    Inventors: Cary James MILLER, Jinghua HU
  • Publication number: 20180217136
    Abstract: Disclosed herein are chips, devices, methods of making the same, and methods of detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.
    Type: Application
    Filed: July 15, 2016
    Publication date: August 2, 2018
    Inventors: Ashutosh Chilkoti, Angus Hucknall
  • Publication number: 20180217137
    Abstract: Understanding the amount of exposure individuals have had to common chemical pollutants critically requires the ability to detect those compounds in a simple, sensitive, and specific manner. Doing so using label-free biosensor technology has proven challenging, however, given the small molecular weight of many pollutants of interest. To address this issue, a pollutant microarray based on the label-free Arrayed Imaging Reflectometry (AIR) detection platform was developed. The sensor that has undergone a two-step blocking process is able to detect three common environmental contaminants (benzo[a]pyrene 200, bisphenol A, and acrolein) in human serum via a competitive binding scheme.
    Type: Application
    Filed: July 25, 2016
    Publication date: August 2, 2018
    Applicant: ADARZA BIOSYSTEMS, INC.
    Inventors: Jared A. CARTER, Emily J. TRIPLETT, Christopher C. STREIMER, Benjamin L. MILLER
  • Publication number: 20180217138
    Abstract: A plasmonic photoconductor sensing platform is provided. The plasmonic photoconductor sensing platform includes an insulating substrate; a semiconducting film placed on top of the insulating substrate; two metal contacts placed at least in part on the semiconducting film to enforce an electric field; a plurality of plasmonic nanostructures deposited on the semiconducting film and physically separated from metal contacts; an insulating layer, the insulating electrically isolating the plasmonic nanostructures from semiconductor; at least one energy source; and at least one microfluidic channel disposed on the insulating layer.
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Inventors: Xu HAN, Hossein Shokri KOJORI, Roger M. LeBLANC, Sung Jin KIM
  • Publication number: 20180217139
    Abstract: An apparatus for testing a fluid sample including a sample receiving member having an opening for receiving a fluid sample, wherein the sample receiving member comprises at least a first and second sample collection chambers, a sample retention member, in fluid communication with the first sample collection chamber, to retain a portion of the fluid sample, and at least one test strip, in fluid communication with the second collection chamber, to indicate the presence or absence of at least one analyte in the fluid sample, wherein the first collection chamber is not in fluid communication with the second collection chamber.
    Type: Application
    Filed: January 27, 2017
    Publication date: August 2, 2018
    Inventor: Raouf A. Guirguis
  • Publication number: 20180217140
    Abstract: Lateral flow devices, methods and kits for performing lateral flow assays are provided.
    Type: Application
    Filed: January 23, 2018
    Publication date: August 2, 2018
    Inventors: William Strong, Clayton T. McKee
  • Publication number: 20180217141
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include placing a subject on a therapeutic regimen and subsequently performing an immunoassay to generate a score based on quantitative data for expression of biomarkers relating to inflammatory biomarkers. The methods further include recommending that the subject either remains on the therapeutic regimen, or is removed from the therapeutic regimen, based on the score.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Inventor: Eric Sasso
  • Publication number: 20180217142
    Abstract: The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.
    Type: Application
    Filed: March 23, 2018
    Publication date: August 2, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Robert Siman
  • Publication number: 20180217143
    Abstract: Provided herein are biomarkers and methods for generating scores useful for assessing psoriatic arthritis (PsA) disease activity in subjects previously diagnosed with PsA. The invention also provides predictive model methods based on the biomarkers, as well as computer systems, software embodiments of the models for scoring and optionally classifying samples, and methods of recommending optimal therapeutic regimens.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Inventors: Eric Sasso, Paul Scott Eastman, Rebecca Bolce, Arthur Kavanaugh
  • Publication number: 20180217144
    Abstract: The present invention relates to methods for identifying the presence or elevated levels of IgG2 specific for O-antigen of Gram-negative bacteria in a subject. The method comprises providing a binding agent specific for said IgG2, contacting the binding agent with the sample, allowing the binding agent and IgG2 to form a complex and thereafter directly or indirectly detecting the complex. Also provided are methods for assessing the severity of infection and/or a worsening of a patient's condition. The present invention also relates to isolated O-antigens.
    Type: Application
    Filed: July 20, 2016
    Publication date: August 2, 2018
    Applicant: The University of Birmingham
    Inventors: Ian Robert Henderson, Timothy Wells
  • Publication number: 20180217145
    Abstract: Apparatuses for sampling mucous from within a sinus to determine if a single sample includes one or more bacterial types indicating bacterial sinusitis comprising an indicator to guide the angle at which a user inserts the apparatus relative to the patient.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Inventors: Joseph SKRABA, Oriana E. HAWKINS, Mohan RAJASEKARAN, Aaron SZYMANSKI, Rishwa BAXI, David SEEBAUER
  • Publication number: 20180217146
    Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis.
    Type: Application
    Filed: March 28, 2016
    Publication date: August 2, 2018
    Inventors: Navin Varadarajan, Gabrielle Romain, Ivan Liadi, Victor Sendra, Badrinath Roysam
  • Publication number: 20180217147
    Abstract: Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.
    Type: Application
    Filed: December 15, 2017
    Publication date: August 2, 2018
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Levi A. Garraway, Caroline Emery, Nikhil Wagle
  • Publication number: 20180217148
    Abstract: The invention described herein relates generally to methods, sensors, devices and kits for electrochemical detection of a target analyte in a sample. In certain aspects, the methods, sensors, devices and kits described herein can be used to detect low concentrations of at least one target analyte using small sample volumes. In some embodiments, methods, sensors and kits for detecting a microbe, microbe fragment or released endotoxin in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces, are also provided herein.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 2, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donald E. INGBER, Olivier Y.F. HENRY, Michael SUPER
  • Publication number: 20180217149
    Abstract: The invention relates to a method which can be used to analyse oxidising species in a sample, comprising the steps which consist of: placing (12) the sample in contact with a first photoluminescent agent, and a second optically active agent, at least the first photoluminescent agent including nanoparticles doped with rare earth elements and being oxidisable, the luminescence of the first photoluminescent agent varying, at least at one first wavelength, with the amount of oxidising species, and the signal emitted by the second optically active agent being constant or varying, at least at one second wavelength other than the first wavelength, with the amount of oxidising species in a direction opposite to the luminescence of the first photoluminescent agent; energising (16) the first and second agents in the sample; measuring (18) the light intensity of the sample at least at said first and second wavelengths; and assessing the presence and/or the amount of oxidising species by interpreting (20) said measured l
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Inventors: Cédric BOUZIGUES, Mouna ABDESSELEM, Antigoni ALEXANDROU, Thierry GACOIN, Jean-Pierre BOILOT
  • Publication number: 20180217150
    Abstract: A system for making molecules, and proteins in particular, suitable for detection by a surface-selective nonlinear optical technique. A first use of the invention is for determining a protein's structure in real space and real time. A second use of the invention is to detect a protein or its activity (conformational change). A third use of the invention is for drug screening. A further aspect of the present invention is measuring probe tilt angle orientation in an oriented protein.
    Type: Application
    Filed: December 13, 2017
    Publication date: August 2, 2018
    Inventor: Joshua S. Salafsky
  • Publication number: 20180217151
    Abstract: The present invention provides a method for reversible labeling an antigen A of a biological specimen comprising said antigen A with a monovalent antigen binding molecule K comprising a binding site B for specifically binding said antigen A, the method comprising the steps a) contacting said biological specimen comprising said antigen A with said antigen binding molecule K, thereby generating a complex of A/K, b) removing the monovalent antigen binding molecule K that is not bound in said complex of A/K, wherein the equilibrium dissociation constant (KD) for the binding of said antigen A and said monovalent antigen binding molecule K has a value of equal or greater than 0.5E-08 M and wherein the dissociation rate constant (k(off)) of said binding has a value of equal or greater than 1E-03 sec-1. In some embodiments of the invention a multimerization component F for multimerization of monovalent antigen binding molecules (F/K complex) is included in the method, wherein said F/K complex can be disrupted.
    Type: Application
    Filed: December 13, 2017
    Publication date: August 2, 2018
    Inventors: Volker NÖLLE, Jennifer PANKRATZ, Gritt GÜNTHER
  • Publication number: 20180217152
    Abstract: Gold nanoparticles functionalized with thiolated, bidentate Schiff base ligands. The Schiff base ligands form a ligand monolayer surrounding and binding to the surface of a gold nanoparticle core through Au—S linkages. The functionalized gold nanoparticle composites have a spherical shape, an average diameter of 7-15 nm and a narrow particle size distribution. Methods of assessing these functionalized gold nanoparticle composites as fluorescent probes in Fe(III) chemosensing applications, methods of preparing the functionalized gold nanoparticle composites and methods of detecting Fe(III) ions with the same are also provided.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Mohammed Nasiruzzaman SHAIKH, Aasif HELAL, Abiola Azeez JIMOH
  • Publication number: 20180217153
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 2, 2018
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Publication number: 20180217154
    Abstract: Disclosed are methods of diagnosing and treating endometriosis, and in particular, endometriosis-associated infertility.
    Type: Application
    Filed: July 20, 2016
    Publication date: August 2, 2018
    Applicant: Saint Louis University
    Inventors: Patrick YEUNG, JR., Daniela SALVEMINI
  • Publication number: 20180217155
    Abstract: Some embodiments are directed to a method for the subcellular proteomic analysis of a test biological sample, including metabolic isotopic labelling of proteins of a test biological sample, fixing of the sample, labelling of the test subcellular compartment, laser microdissection of said subcellular compartment, extracting the proteins of said subcellular compartment, reversion of the fixing and proteolysis, analyzing the peptides obtained by mass spectrometry, and identifying the analyzed peptides.
    Type: Application
    Filed: July 13, 2016
    Publication date: August 2, 2018
    Inventors: Frédéric SALTEL, Anne-Aurélie RAYMOND, Zakaria EZZOUKHRY
  • Publication number: 20180217156
    Abstract: The present invention relates to a use of a tertiary amine as buffer in sample preparation, preferably for mass spectrometry and/or UV/vis spectroscopy, wherein the sample comprises proteins, polypeptides and/or peptides, and said sample preparation comprises: (a) protein, polypeptide and peptide denaturation; and (b) chemical isotope labelling and/or chemical cross-linking, wherein said sample preparation does not use primary amine buffers.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Inventors: Nils A. KULAK, Garwin PICHLER, Matthias MANN
  • Publication number: 20180217157
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: March 28, 2018
    Publication date: August 2, 2018
    Inventors: Nigel CLARKE, Zhaohui CHEN
  • Publication number: 20180217158
    Abstract: The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer.
    Type: Application
    Filed: January 25, 2018
    Publication date: August 2, 2018
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Karl Erik Hellstrom, Ingegerd Hellstrom, Pu Liu, Jade Jaffar, Elizabeth Swisher
  • Publication number: 20180217159
    Abstract: The present invention provides a method and a kit for predicting the response to an immunomodulatory treatment in patients that present an inflammatory disease such as multiple sclerosis, which are based on the quantification of the plasma levels ratio of cytokines IL-17F, IFN-? and IL-10 in a biological sample from the patient taken before initiating the treatment.
    Type: Application
    Filed: May 6, 2016
    Publication date: August 2, 2018
    Inventors: Rodrigo Antonio NAVES PICHUANTE, Claudia CÁRCAMO RODRÍGUEZ