Patents Issued in August 9, 2018
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Publication number: 20180222823Abstract: The method according to this disclosure is a method for separating an unsaturated hydrocarbon having 2 or 3 carbon atoms and a halogenated unsaturated carbon compound formed by replacing at least one of hydrogen atoms included in the unsaturated hydrocarbon with a fluorine atom, from each other and is a method for selectively adsorbing either the unsaturated hydrocarbon or the halogenated unsaturated carbon compound by a porous coordination polymer that includes a metallic ion having a valence of 2 to 4 and an aromatic anion having 1 to 6 aromatic ring(s).Type: ApplicationFiled: June 15, 2016Publication date: August 9, 2018Applicants: DAIKIN INDUSTRIES, LTD., KYOTO UNIVERSITYInventors: Tatsuya MORIKAWA, Mana SHIMOKAWA, Katsuki FUJIWARA, Satoshi TOKUNO, Masakazu HIGUCHI, Susumu KITAGAWA
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Publication number: 20180222824Abstract: A process for separating dimethyl biphenyl (DMBP) isomers, including contacting a mixture of 3,3?-DMBP, 3,4?-DMBP and 4,4?-DMBP in a first solvent with a 12-member ring zeolite exchanged with potassium or barium, or combinations thereof, and adsorbing the 3,3?-DMBP onto the 12-member ring zeolite, such as by passing the mixture through at least one packed bed of the potassium and/or barium exchanged 12-member ring zeolite.Type: ApplicationFiled: February 1, 2018Publication date: August 9, 2018Inventors: Benjamin A. McCOOL, Michael P. LANCI, Randall D. PARTRIDGE, Carla S. PEREIRA
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Publication number: 20180222825Abstract: A support structure for a reconfigurable molecule includes a first support portion having a first mounting region; a second support portion having a second mounting region; and a rotatable molecule anchored between the first support portion and the second support portion on the first mounting region and the second mounting region, the rotatable molecule having an internal rotational axis extending from the first mounting region to the second mounting region; wherein the first support portion and the second support portion are mirror images of one another.Type: ApplicationFiled: February 6, 2017Publication date: August 9, 2018Inventors: Michael C. Pitman, Teresa J. Clement, Glafkos K. Stratis, Alphonso A. Samuel, Alex Dely, Wayne L. Sunne
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Publication number: 20180222826Abstract: A reconfigurable polar molecule includes a symmetric nonpolar molecule portion having an elongated shape defined by a longitudinal axis and lateral axis, the longitudinal axis being longer than the lateral axis; a positive ionically charged group at a first end and a negative ionically charged group at a second end of the longitudinal axis, the positive and negative ionically charged groups forming a permanent dipole; a first bridging group and a second bridging group on opposing ends of the lateral axis, the first and second bridging groups being linear nonpolar groups; and a first support portion bonded to the first bridging group, and a second support portion bonded to the second bridging group, the first bridging group and the second bridging group being nonpolar and having structures that enable free rotation of the symmetric nonpolar molecule portion through the first bridging group and the second bridging group.Type: ApplicationFiled: February 6, 2017Publication date: August 9, 2018Inventors: Michael Pitman, Teresa J. Clement, Glafkos K. Stratis, Alphonso A. Samuel, Alex Dely, Wayne L. Sunne
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Publication number: 20180222827Abstract: A chemical reactor system includes: a feed; a methane oxychlorination catalyst, wherein a product of an oxychlorination reaction is dichloromethane; and a dichloromethane conversion catalyst, wherein the dichloromethane conversion catalyst provides a product stream having a dichloromethane selectivity less than 5%. The addition of the dichloromethane conversion catalyst to the reactor bed can decrease the amount of dichloromethane produced and increase the amount of monochloromethane produced. Accordingly, dichloromethane does not have to be separated from the product stream and the monochloromethane can then be used to produce other products, such as olefins.Type: ApplicationFiled: April 4, 2018Publication date: August 9, 2018Inventors: Kaiwalya SABNIS, Dustin FICKEL, Heng SHOU, Edouard MAMEDOV
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Publication number: 20180222828Abstract: The purpose of the present invention is to obtain a fluorine-containing compound which is easily stabilized without irradiation of ultraviolet light, by efficiently converting a C—I bond in an iodine-containing compound having a group represented by —CFRf—I (wherein Rf is a fluorine atom or a perfluoroalkyl group) to a C—H bond. A method for producing a fluorine-containing compound having an iodine atom content reduced than the following iodine-containing compound, which comprises subjecting an iodine-containing compound having a group represented by —CFRf—I (wherein Rf is a fluorine atom or a perfluoroalkyl group) to deiodinating treatment in the presence of an organic peroxide and a hydrogen-containing compound having a group represented by —CHR1—CHR2—CHR3— (wherein R1, R2 and R3 are each independently a hydrogen atom or an alkyl group).Type: ApplicationFiled: April 3, 2018Publication date: August 9, 2018Applicant: ASAHI GLASS COMPANY, LIMITEDInventor: Atsushi Watakabe
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Publication number: 20180222829Abstract: A method for the preparation of polyol from an unsaturated TAG oil that can function similarly to castor oil in certain applications. The method comprises controlled epoxidation of the TAG oil with an acid and an oxidizing agent to obtain a partially epoxidized TAG oil with desired iodine and oxirane values; hydroxylating the partially epoxidized TAG oil using a monoalcohol and a solid acid catalyst to obtain the polyol. The resulting polyols are comprised of a triglyceride structure and hydroxyl values, viscosities, and colors that are similar to castor oil.Type: ApplicationFiled: July 29, 2016Publication date: August 9, 2018Applicant: The Governors of the University of AlbertaInventors: Jonathan M. CURTIS, Tolibjon S. OMONOV, Ereddad KHARRAZ
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Publication number: 20180222830Abstract: Process for preparing monoethylene glycol (MEG) by metal-catalyzed reaction of a dialkyl oxalate of the formula I where R1 and R2 are each, independently of one another, methyl, ethyl, n-propyl or isopropyl, with hydrogen (H2), wherein the dialkyl oxalate (I) is used as melt or as a solution in a solvent, dialkyl oxalate (I) and H2 are used in a molar ratio of H2: dialkyl oxalate (I) in the range from 4.0 to 30 and the reaction is carried out continuously in a reactor at a cross-sectional loading of 10 m/s, a temperature in the range from 150 to 270° C., a pressure in the range from 150 to 390 bar and in the presence of a chromium-free heterogeneous catalyst comprising copper.Type: ApplicationFiled: July 26, 2016Publication date: August 9, 2018Inventors: Alexander DUEFERT, Rolf PINKOS, Michael REISER, Philipp BRUEGGEMANN, Gerhard THEIS
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Publication number: 20180222831Abstract: A method of producing at least one derivate of a carboxylic acid. The method includes reacting a carboxylic acid with an auxiliary alkanol on a first catalyst to form a produced ester. A fraction of the produced ester is optionally separated to form a first separated ester. At least a fraction of said produced ester is reacted with hydrogen on a second catalyst to produce a mixture of product alkanol, auxiliary alkanol and optionally residual ester. The product alkanol is separated from the auxiliary alkanol in the mixture to form separated product alkanol, separated auxiliary alkanol, and optionally a second separated ester. The separated auxiliary alkanol is recycled to the reaction. Methods and catalysts for converting alcohols and acids to hydrocarbon jet and diesel fuels are also described.Type: ApplicationFiled: August 5, 2016Publication date: August 9, 2018Applicant: White Dog Labs, Inc.Inventors: Michael E. WRIGHT, Aharon M. EYAL
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Publication number: 20180222832Abstract: A method having the steps of heating a first mixture to at least 40° C. for a first period of time, wherein the first mixture contains the following two substances: a first aluminum-containing species and an alkylated phenol compound; after heating the first mixture to at least 40° C. for a first period of time, adding water to the first mixture to thereby create a second mixture, wherein the second mixture contains the following two substances: a second aluminum-containing species and the alkylated phenol compound; and removing the second aluminum-containing species from the second mixture by passing the second mixture through a first filter.Type: ApplicationFiled: February 5, 2018Publication date: August 9, 2018Inventors: Mark Barkett, Sangha Kim
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Publication number: 20180222833Abstract: The present invention relates to the technical field of chemical engineering and catalysis. Provided are an application of an ionic liquid in propylene glycol ether synthesis and a method for synthesizing a propylene glycol ether. The ionic liquid is a methyl carbonate ionic liquid, and is used as a catalyst for catalyzing propylene glycol ether synthesis. The method for synthesizing the propylene glycol ether comprises the following steps: placing propylene oxide and an alcohol within a reactor to contact a catalyst, and heating the mixture in an enclosed environment to 50-200° C. to obtain the propylene glycol ether, wherein the catalyst is a methyl carbonate ionic liquid. The method for synthesizing propylene glycol ether provided in the present invention is a green synthesis technique, and does not require special production equipment. The method has simple and easily controllable processes, and can be used in industrial production and applications.Type: ApplicationFiled: November 14, 2016Publication date: August 9, 2018Inventors: Ruixia LIU, Suojiang ZHANG, Ruirui ZHANG, Junping ZHANG, Shengxin CHEN, Fei (6) DAI
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Publication number: 20180222834Abstract: An object of the present invention is to remove a compound A from “sevoflurane containing fluoromethyl-1,1,3,3,3-pentafluoroisopropenyl ether (compound A)” so as to collect high-purity sevoflurane. The present invention concerns a method for producing sevoflurane containing substantially no compound A, comprising the following steps of: bringing a composition containing hydrogen fluoride (HF) and water at a mass ratio of 1:1 to 1:30 into contact with a 1st organic liquid containing sevoflurane and a compound A, thereby obtaining a 2nd organic liquid containing the compound A in an amount that is lower than that in the 1st organic liquid (step 1a); and distilling the 2nd organic liquid under the presence of a degradation inhibitor, thereby obtaining sevoflurane containing substantially no compound A as a main distillation fraction (step 2).Type: ApplicationFiled: March 30, 2017Publication date: August 9, 2018Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Takaaki YOSHIMURA, Toshihiko OONO, Shinya AKIBA, Masaki FUJIWARA
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Publication number: 20180222835Abstract: Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.Type: ApplicationFiled: April 2, 2018Publication date: August 9, 2018Inventors: Ronald C. Bakus, II, Louis Perez, Camille Mol, James Rogers, Gabriel Rodriguez
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Publication number: 20180222836Abstract: A one-pot process is disclosed for the preparation of pharmaceutical grade ferric citrate that includes preparing a ferric hydroxide slurry followed by treatment with a citrate ion source to yield pharmaceutical grade ferric citrate.Type: ApplicationFiled: August 4, 2016Publication date: August 9, 2018Inventors: Anurag Anil Smart, Yogesh Subhash Aher, Sunilkumar Vinubhai Gohel, Rajinder Singh Siyan, Nandu Baban Bhise, Girij Pal Singh
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Publication number: 20180222837Abstract: The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm-based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).Type: ApplicationFiled: April 3, 2018Publication date: August 9, 2018Inventors: Sambandan TG, Chokyun RHA, Ravigadevi SAMBANTHAMURTHI, Anthony J. Sinskey, Yew Ai TAN, Kalyana Sundram P. MANICKAM, Mohd Basri WAHID
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Publication number: 20180222838Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease.Type: ApplicationFiled: November 14, 2017Publication date: August 9, 2018Inventors: Leticia M. Toledo-Sherman, Celia Dominguez, Michael Prime, William Leonard Mitchell, Peter Johnson, Naomi Went
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Publication number: 20180222839Abstract: Disclosed are methods for the heterogeneous catalytic transesterification of compounds having one or more ester groups and groups reactive under transesterification conditions, such as 1,1-disubstituted alkene compounds, with alcohols or esters and novel compositions prepared therefrom. Further disclosed are novel compounds and compositions prepared as a result of the methods.Type: ApplicationFiled: April 3, 2018Publication date: August 9, 2018Inventors: Jeffrey M. Sullivan, William Barrett, Ami Doshi
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Publication number: 20180222840Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: ApplicationFiled: April 5, 2018Publication date: August 9, 2018Applicant: BRACCO IMAGING S.P.A.Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
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Publication number: 20180222841Abstract: A preparation method of vegetable oil polyol, which is obtains by carrying out allylic oxidation treatment of vegetable oil, increasing the content of hydroxyl group in the product and then one step reaction between epoxidation and ring-opening. At the same time, the present invention also discloses novel vegetable oil polyol made by the preparation method and the application of the vegetable oil polyol in preparation of polyurethane foam material. Compared with the prior art, the method has the advantages of simple operation, low energy consumption and low side reaction occurrence rate.Type: ApplicationFiled: January 28, 2016Publication date: August 9, 2018Inventors: Kai GUO, Zheng FANG, Dong JI, Junjie TAO, Xin LI, Li WAN, Ning ZHU, Kai ZHANG, Pingkai OUYANG
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Publication number: 20180222842Abstract: An object of the present invention is to provide a method for efficiently eliminating water from a composition containing an acrylic acid derivative and water. This problem is solved by a method for eliminating water from a composition A containing: (A) an acrylic acid derivative represented by Formula (I): wherein R1 and R2 are identical or different, and each represents alkyl, fluoroalkyl, aryl that may have one or more substituents, halogen, or hydrogen, R3 represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen, and X represents alkyl, fluoroalkyl, halogen, or hydrogen; and (B) water, the method comprising step A of bringing the composition A into contact with a zeolite.Type: ApplicationFiled: August 5, 2016Publication date: August 9, 2018Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Makoto MATSUURA, Yosuke KISHIKAWA, Asako YOSHIYAMA, Sumi ISHIHARA
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Publication number: 20180222843Abstract: The problem solved by the present invention is to provide a method for efficiently purifying acrylic acid derivative (I), more specifically a method for efficiently eliminating alcohol (II) from a composition containing acrylic acid derivative (I) and alcohol (II).Type: ApplicationFiled: August 5, 2016Publication date: August 9, 2018Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Makoto MATSUURA, Yosuke KISHIKAWA, Asako YOSHIYAMA
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Publication number: 20180222844Abstract: A compound represented by formula (1) provides a high performance organic electroluminescence device and a novel material for realizing such an organic electroluminescence device: wherein R1 to R6, a to f, L1 to L3, and Ar are as defined in the description.Type: ApplicationFiled: August 1, 2016Publication date: August 9, 2018Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Tomoki KATO, Taro YAMAKI, Masahiro KAWAMURA, Hirokatsu ITO
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Publication number: 20180222845Abstract: Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.Type: ApplicationFiled: October 18, 2017Publication date: August 9, 2018Inventors: Paul McGlynn, Roger BAKALE, Craig STURGE
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Publication number: 20180222846Abstract: A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic mineral collectors require such varying degrees of solubility and molecular weight. The family of the present invention allows for the optimization of both parameters and an increase in collector efficiency.Type: ApplicationFiled: April 9, 2018Publication date: August 9, 2018Inventor: Thomas P. Daly
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Publication number: 20180222847Abstract: A compound of the general formula (I) in which R1, R2 and R3 are independently selected from C1-4-alkyl and C1-4-hydroxyalkyl; each R4 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; each R5 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; m is 2, 3, 4 or 5; n is 2, 3, 4 or 5; and o is an integer from 0 to 10. A preferred compound of the formula (I) is 2-(2-tert-butylaminoethoxy)ethylamine. Absorbents comprising a compound of the formula (I) have rapid absorption of carbon dioxide from fluid streams and are also suitable for processes for the simultaneous removal of H2S and CO2, where given H2S limits have to be observed but complete removal of CO2 is not required.Type: ApplicationFiled: August 20, 2015Publication date: August 9, 2018Applicant: BASF SEInventors: Thomas INGRAM, Marion DA SILVA, Georg SIEDER
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Publication number: 20180222848Abstract: The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.Type: ApplicationFiled: August 2, 2016Publication date: August 9, 2018Inventors: Thomas VAN DER DOES, Harold Monro MOODY, Weidong LI
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Publication number: 20180222849Abstract: Novel dissymmetric N,N-dialkylamides which meet the following formula (I): where R represents a linear or branched alkyl group at C8 to C15. A method for synthesizing these N,N-dialkylamides, and to the uses of same as extractants, alone or in admixture, in order to extract uranium and/or plutonium from an aqueous acid solution, or to totally or separate uranium from plutonium from an aqueous acid solution and, in particular, an aqueous solution resulting from dissolving spent nuclear fuel in nitric acid. Further, a method for processing an aqueous solution resulting from the dissolution of a spent nuclear fuel in nitric acid, allowing the uranium and plutonium contained in the solution to be extracted, separated and decontaminated in a single cycle, without requiring any plutonium reduction operation, and in which one of the aforementioned N,N-dialkylamides or a mixture of same is used as extractant.Type: ApplicationFiled: July 28, 2016Publication date: August 9, 2018Inventors: Manuel Miguirditchian, Pascal Baron, Sandra Lopes Moreira, Gaëlle Milanole, Cécile Marie
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Publication number: 20180222850Abstract: The present disclosure relates generally to catalyst materials and processes for making and using them. More particularly, the present disclosure relates to molybdenum, bismuth and iron-containing metal oxide catalyst materials useful, for example, in the partial oxidation or ammoxidation of propylene or isobutylene, processes for making them, and processes for making acrolein, methacrolein, acrylonitrile, and methacrylonitrile using such catalysts.Type: ApplicationFiled: February 8, 2017Publication date: August 9, 2018Inventors: Hailian LI, Claus G. LUGMAIR
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Publication number: 20180222851Abstract: The present disclosure relates generally to catalyst materials and processes for making and using them. More particularly, the present disclosure relates to molybdenum, bismuth and iron-containing metal oxide catalyst materials useful, for example, in the partial oxidation or ammoxidation of propylene or isobutylene, processes for making them, and processes for making acrolein, methacrolein, acrylonitrile, and methacrylonitrile using such catalysts.Type: ApplicationFiled: February 8, 2017Publication date: August 9, 2018Inventors: Claus G. LUGMAIR, Hailian LI
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Publication number: 20180222852Abstract: The invention relates to synthesis of methyl carbamate (MC) and dimethyl carbonate (DMC) in presence of stripping inert gas or superheated methanol vapors using packed column reactor and bubble column reactor.Type: ApplicationFiled: January 30, 2018Publication date: August 9, 2018Inventors: Vivek Vinayak Ranade, Ashutosh Anant Kelkar, Vilas Hari Rane, Anil Kisan Kinage, Savita Kiran Shingote, Lalita Sanjib Roy
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Publication number: 20180222853Abstract: The present application relates to compounds represented by general formula (I), general formula (II) or general formula (III), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (I), general formula (II) or general formula (III) have inhibitory activities against isocitrate dehydrogenase 2 (IDH2), thereby being capable of treating IDH2 mutation-induced cancers.Type: ApplicationFiled: July 29, 2016Publication date: August 9, 2018Inventors: Shulong WANG, Na ZHAO, Xijie LIU, Yuandong HU, Hui ZHANG, Hong LUO, Yong PENG, Dengming XIAO, Yongxin HAN, Xiquan ZHANG, Xin TIAN
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Publication number: 20180222854Abstract: Methods of making an alpha-olefin sulfonic dimer acid (AOS dimer acid) are disclosed. In one method, an alpha-olefin is sulfonated, preferably with sulfur trioxide, to produce a mixture comprising an alpha-olefin sulfonic acid (AOS acid) and sulfur dioxide. This mixture is then heated while purging sulfur dioxide and hydrogen sulfide from the reactor to produce an AOS dimer acid composition. In another method, the AOS acid mixture is treated to remove sulfur dioxide and is then heated to produce an AOS dimer acid composition. With either method, the resulting AOS dimer acid composition has at least a 30% decrease in the level of elemental sulfur when compared with that of an AOS dimer acid composition prepared by a similar process in the absence of any active removal of sulfur dioxide or hydrogen sulfide. AOS dimer acid compositions and salts of the AOS dimer acids, which are useful surfactants for oilfield and other applications, are also disclosed.Type: ApplicationFiled: July 28, 2016Publication date: August 9, 2018Inventors: Gregory P. Dado, Aaron Sanders, Xue Min Dong, Carolina E. Rojas
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Publication number: 20180222855Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.Type: ApplicationFiled: February 12, 2018Publication date: August 9, 2018Inventors: Wenjun ZHOU, Kyle GEE, Yolanda TENNICO, Peter SLADE, Hee Chol KANG, Shaheer KHAN, Brian EVANS, James STRAY
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Publication number: 20180222856Abstract: Disclosed are novel compounds—benzenesulfonamides of general formulas (I) and The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression. Also disclosed are method of treatment using such compounds.Type: ApplicationFiled: September 1, 2015Publication date: August 9, 2018Inventors: Daumantas MATULIS, Edita CAPKAUSKAITE, Andrius ZAKSAUSKAS, Vaida MORKUNAITE
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Publication number: 20180222857Abstract: Compound of formula I: wherein: A is selected from: (i) where RF1 is H or F; (ii) (iii) a N-containing C6 heteroaryl group; and B is where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.Type: ApplicationFiled: June 9, 2016Publication date: August 9, 2018Applicants: MONASH UNIVERSITY, The Walter and Eliza Hall Institute of Medical ResearchInventors: Anne Kathrin VOSS, Jonathan BAELL, Huu Nghi NGUYEN, David J. LEAVER, Benjamin L. CLEARY, H. Rachel LAGIAKOS, Bilal Nadeem SHEIKH, Timothy John THOMAS
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Publication number: 20180222858Abstract: The present invention concerns a compound of following formula (I): where: —R1 is H or OH, —R2 is a (C1-C6)alkyl, COOH, COO—((C1-C6)alkyl) or thiazolyl group, —R3 is H or a (C1-C6)alkyl group, and —R4 is: ?a straight-chain or branched, saturated or unsaturated hydrocarbon group having 1 to 8 carbon atoms substituted by one or more groups chosen from among OH and NR5R6, ?—(CH2CH2X1)(CH2CH2X2)a2(CH2CH2X3)a3(CH2CH2X4)a4(CH2CH2X5)a5R7, ?an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or ?a heterocycle-(C1-C8)alkyl group optionally substituted by one or more groups chosen from among (C1-C6)alkyl, OH and NR12R13 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.Type: ApplicationFiled: September 19, 2017Publication date: August 9, 2018Applicant: PIERRE FABRE MEDICAMENTInventors: Michel PEREZ, Ian RILATT, Marie LAMOTHE
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Publication number: 20180222859Abstract: This invention relates to an improved process for the selective production of N-methyl pyrrolidone (NMP) from gamma-butyrolactone and monomethyl amine preferably in aqueous form in the presence of a catalyst under comparatively milder conditions than the processes well known in the prior art of literature. The process is economically viable as it provides higher yield and selectivity for NMP which reduces the cost of separation of NMP from GBL. The catalyst shows good recyclability without significant loss in catalytic activity and no frequent regeneration is required.Type: ApplicationFiled: May 17, 2016Publication date: August 9, 2018Inventors: Indrajit Kumar GHOSH, Suman Lata JAIN, Praveen Kumar KHATRI, Siddharth Sankar RAY, Madhukar Onkarnath GARG
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Publication number: 20180222860Abstract: Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.Type: ApplicationFiled: August 3, 2016Publication date: August 9, 2018Inventors: David A. Claremon, Lawrence Wayne Dillard, Yi Fan, Stephen D. Lotesta, Suresh B. Singh, Colin M. Tice, Wei Zhao, Linghang Zhuang
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Publication number: 20180222861Abstract: Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.Type: ApplicationFiled: April 5, 2018Publication date: August 9, 2018Inventors: Weiping Tang, Xiaoxun Li, Dongxu Shu, Gabrielle N. Winston-McPherson
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Publication number: 20180222862Abstract: A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I.Type: ApplicationFiled: August 4, 2016Publication date: August 9, 2018Inventors: Sacha Ninkovic, Michael Raymond Collins, Stefano Crosignani, Andreas Maderna, Indrawan James McAlpine, Stephanie Anne Scales, Martin Wythes
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Publication number: 20180222863Abstract: What is described is a compound wherein R1 and R2 are the same or different, each a linear or branched alkyl consisting of 1 to 20 carbons, or a linear or branched alkenyl or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a bond, a linear alkylene of 1-18 carbons, or a linear alkenylene consisting of 2 to 18 carbons; L3 is a bond or a linear or branched alkylene consisting of 1 to 6 carbons; L4 is a bond or a methylene; X is S or O, R3 is a linear or branched alkylene consisting of 1 to 6 carbons, and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 9, 2018Publication date: August 9, 2018Inventors: Joseph E. Payne, Padmanabh Chivukula, Steven P. Tanis
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Publication number: 20180222864Abstract: Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.Type: ApplicationFiled: August 18, 2016Publication date: August 9, 2018Inventors: John F. KADOW, B. Narasimhulu NAIDU, Yong TU
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Publication number: 20180222865Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.Type: ApplicationFiled: August 5, 2016Publication date: August 9, 2018Applicant: API CORPORATIONInventors: Naoyuki WATANABE, Takanobu IURA, Hideki OOMIYA, Masaki NAGAHAMA
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Publication number: 20180222866Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.Type: ApplicationFiled: April 4, 2018Publication date: August 9, 2018Applicant: Hoffmann-La Roche Inc.Inventors: Maude GIROUD, Wolfgang HAAP, Bernd KUHN, Rainer E. MARTIN
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Publication number: 20180222867Abstract: The invention provides pyrazolyl guanidine compounds that inhibit F1F0-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.Type: ApplicationFiled: February 14, 2018Publication date: August 9, 2018Inventors: Thomas D. Aicher, Donald J. Skalitzky, Clarke B. Taylor
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Publication number: 20180222868Abstract: A series of substituted indazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.Type: ApplicationFiled: June 7, 2016Publication date: August 9, 2018Inventors: Prafulkumar Tulshibhai Chovatia, Martin Clive Hutchings, Boris Kroeplien, James Thomas Reuberson
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Publication number: 20180222869Abstract: A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. Also described are compositions including the novel drugs and methods of treating AR positive cancer using the compositions.Type: ApplicationFiled: April 3, 2018Publication date: August 9, 2018Inventor: Zhihui Qin
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Publication number: 20180222870Abstract: The present invention relates to the adduct (2E)-but-2-enedioic acid-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-yl)propanoic acid (1:4), methods for preparing this adduct, pharmaceutical compositions comprising this adduct and also the use of this adduct for preparing a medicament for the treatment of a disease.Type: ApplicationFiled: July 22, 2016Publication date: August 9, 2018Applicant: Bayer Pharma AktiengesellschaftInventor: Heiko SCHIRMER
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Publication number: 20180222871Abstract: The present invention relates to a method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives of the general formula (I) in which R1 represents a hydrogen atom or R1 represents a group selected from the series of C1-C3-alkyl-, C1-C3-alkoxy-, C1-C3-haloalkyl- and C1-C3-haloalkoxy-, R2 represents a hydrogen atom or a C1-C3-alkyl group, R3 represents a hydrogen atom or a C1-C3-alkyl group, R4 represents a cyclohexyl group, which is optionally singly or multiply substituted by a C1-C3-alkyl group, and R5 represents a hydrogen atom or a C1-C6-alkyl group; and also intermediates which may be used to prepare substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives.Type: ApplicationFiled: July 25, 2016Publication date: August 9, 2018Applicant: Bayer Pharma AktiengesellschaftInventor: Heiko SCHIRMER
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Publication number: 20180222872Abstract: Fluorene derivatives that are connected in one or more of the 1-, 1?-, 4-, or 4?-positions in any combination to a carbon atom of a diaryl substituted triazinyl or pyrimidinyl derivative. The fluorene derivatives are not spirobifluorene derivatives. The compounds are suitable for use in electronic devices, in particular organic electroluminescent devices, comprising these compounds. In some embodiments, the compounds are used as matrix materials for phosphorescent or fluorescent emitters as well as a hole-blocking or an electron-transport layer.Type: ApplicationFiled: July 1, 2016Publication date: August 9, 2018Applicant: Merck Patent GmbHInventors: Anja Jatsch, Amir Hossain Parham, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber