Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: A pharmaceutical composition and method for treating or attenuating a mood or stress-related disorder in a subject having normal or low inflammatory state is provided. In some embodiments, the pharmaceutical composition and method of the invention comprise activating or stimulating microglia for treatment of mood or stress-related disorder.

Abstract: The disclosure provides anti-CD70 antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs) comprising an antigen binding molecule that specifically binds to CD70, polynucleotides encoding the same, and in vitro cells comprising the same. The polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered TCR and/or CAR T cell therapy for the treatment of a patient suffering from a cancer. In one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.

Abstract: The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a single-domain antibody. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune re-sponse by regulating T regulatory cells.

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

Abstract: The present invention relates to a method for increasing the galactose content of a recombinant protein produced in mammalian cells, wherein during the cultivation of said cells the pH of the cell culture is changed and a composition comprising nucleosides, transition metal salts and/or sugars is fed.

Abstract: Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed methods and compositions. Also disclosed are methods of restoring adaptive immune T cell tolerance, treating pernicious insulitis, improving immune tolerance, and treating autoimmune diseases using the disclosed methods and compositions.

Abstract: The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.

Abstract: Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

Abstract: Agents and compounds which can be used to modulate the activity of the complement system, novel biological targets associated with such modulation, and pharmaceutical compositions, medicaments and methods of treatment for use in preventing, ameliorating or treating diseases that are characterised by inappropriate complement activity. These diseases include age-related macular degeneration (AMD), meningitis, renal disease, autoimmune disease and inflammation. Therapeutic antibodies and screening assays for identifying agents useful in treating these diseases are also provided.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20X21AFIX25X26LWD (SEQ ID NO. 369). The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.

Abstract: The present invention provides a chimeric protein comprising: a) a single chain variable fragment (scFv) that binds to a mammalian IgE at an epitope within the amino acid sequence VDGQKATNIFPYTAPGTK (SEQ ID NO:1) of canine IgE or at an epitope within the corresponding amino acid sequence of a different mammalian species; b) a linker peptide; and c) an amino acid sequence comprising an IgE high affinity receptor alpha chain, and methods of use thereof.

Abstract: Provided herein are cell penetrating conjugates. The conjugates include non-cell penetrating proteins connected through a phosphorothioate nucleic acid, wherein the phosphorothioate nucleic acid enhances intracellular delivery of the non-cell penetrating proteins. Also provided are methods and kits including the conjugates provided herein.

Abstract: The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents, comprising engineered immunoglobulin alleles. Mutations in the alleles are designed to compromise allelic exclusion and have potential to be exploited for the isolation of bispecific antibodies.

Abstract: A starch-based food thickener with low molecular weight and a preparation method thereof, comprising the steps of: adding starch powders with 5%-30% moisture content into an atmospheric pressure low-temperature dielectric barrier discharge plasma reactor, regulating the discharge gap to 0.2 mm-0.8 mm at atmospheric pressure, the discharge input voltage to 30 V-70 V, and the discharge current to 0.2 A-2.4 A, subjecting the materials in a fluidized state to plasma action in the circulating system by regulating the air flow rate with controlling time longer than 0.5 min, and then taking out the product after the completion of the reaction, i.e., to obtain a starch-based food thickener with low molecular weight. The method has such advantages as a simple technique involved, low cost, recyclable processing, large processing capacity, superior reaction uniformity, etc., and is also capable of efficiently and quickly degrading the molecular weight of starch, e.g., by 1-3 order(s) of magnitude within a short time.

Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.

Abstract: The disclosure relates to benzyl ?-(1?3)-glucan, compositions comprising benzyl ?-(1?3)-glucan, and blends comprising benzyl ?-(1?3)-glucan and one or more polymers. Also disclosed are fibers comprising benzyl ?-(1?3)-glucan, and articles comprising such fibers, including articles such as a carpet, a textile, a fabric, yarn, or apparel.

Abstract: Methods for producing an activated pectin-containing biomass composition are provided. The method includes (A) mixing a starting pectin-containing biomass material comprising an insoluble fiber component and an insoluble protopectin component with an aqueous solution of an alcohol to form a mixture; (B) activating the starting pectin-containing biomass material to form an activated pectin-containing biomass material comprising the insoluble fiber component and a soluble pectin component by subjecting the starting pectin-containing biomass material to (i) an activating solution formed by adding acid to the mixture to adjust the pH of the mixture within the range from at or about 0.5 to at or about 2.

Abstract: A latex processing system and method involves mixing a latex and at least one solvent blend in an extruder, in order to remove resin found in the latex and to coagulate the latex to form a coagulum. The at least one solvent blend has a first solvent configured to coagulate the latex, and a second solvent configured to swell the resulting coagulum. In particular, a series of the solvent blends may be used at different locations along a length of the extruder, and may further include distinct blends of the first solvent and the second solvent, introduced at the different locations, and having different ratios of the first solvent and the second solvent.

Abstract: Disclosed is a latex composition for dip-molding and a dip-molded article produced therefrom. More specifically, a dip-molded article having slow syneresis, less stickiness and superior tensile strength is produce by dip-molding of a carbonic acid-modified nitrile-based copolymer latex having increased molecular stability due to the combined use of alkenylsuccinate, which is an emulsifier crosslinkable with the latex and having a flexible molecular structure.

Abstract: The invention pertains to a method for making a fluoropolymer dispersion, said method comprising an aqueous emulsion polymerization of one or more fluorinated monomers wherein said aqueous emulsion polymerization is carried out in an aqueous medium comprising a surfactant mixture [mixture (S)] comprising: at least one perfluorohexanoic acid or salt thereof [surfactant (C6)], in an amount of 1 to 5 g/I, with respect to said aqueous medium; and at least one linear bifunctional perfluoropolyether surfactant [surfactant (PFPE)] complying with formula (I) here below: XpOOC—CF2-0-(CF20) n(CF2CF20)m-CF2—COOXp (I) wherein: Xp, equal to or different from each other, is a hydrogen atom, a monovalent metal, preferably an alkaline metal, or an ammonium group of formula —N(R?n)4, wherein R?n, equal or different at each occurrence, is a hydrogen atom or a C1-C6hydrocarbon group, preferably an alkyl group; n? and m? are independently integers >0 such that the number average molecular weight of the surfactant (PFPE) is of

Abstract: Novel support material formulations, characterized as providing a cured support material with improved dissolution rate, while maintaining sufficient mechanical strength, are disclosed. The formulations comprise a water-miscible non-curable polymer, a first water-miscible, curable material and a second, water-miscible material that is selected capable of interfering with intermolecular interactions between polymeric chains formed upon exposing the first water-miscible material to curing energy. Methods of fabricating a three-dimensional object, and a three-dimensional object fabricated thereby are also disclosed.

Abstract: A catalyst component comprising Ti, Mg, Cl, and an electron donor compound having porosity of at least 0.2 cm3/g and characterized by the fact that it further comprises Cu oxide, with the proviso that when the electron donor compound is selected from esters of phthalic acids, the porosity is of at least 0.45 cm3/g.

Abstract: A method for producing chlorinated polyvinyl chloride includes placing polyvinyl chloride in a powder form in a reactor; introducing chlorine gas into the reactor, wherein the chlorine gas is brought into contact with polyvinyl chloride; irradiating the polyvinyl chloride with UV light The UV light has a wavelength ranging from 280 to 420 nm and an irradiation intensity in a range of 0.0005 to 7.0 W per kg of the polyvinyl chloride.

Abstract: A ?-phase PVDF is prepared through a controllable dehydrofluorination under either a basic or high temperature condition. PVDF is degraded by losing hydrogen fluoride (HF) and either carbon-carbon double bonds form in the molecular backbone or single bonds form crosslinking the two polymer chains. These changes in structure influence the crystallization behavior of PVDF and therefore, influence the electrical properties by changing the arrangement of the dipoles.

Abstract: A low density polyethylene composition characterized by having a density in range of 0.91 to 0.94 gm/cm3, a melt index in the range of 1 to 5 g/10 minutes, a gel permeation chromatography branching index in the range of 1.2 to 1, a polydispersity index in the range of 3.5 to 7.5, a viscosity ratio in the range of 0.7 to 1, and a long chain branching frequency greater than zero at a log molecular weight (log(MW)) value in the range of 4 to 5.5. Film formed from the polyethylene compositions with favorable haze and gloss characteristics, and a process for forming such film, are also described.

Abstract: The present invention relates to a process for the continuous preparation of polypropylene in a reactor from propylene and optionally ethylene and/or at least one other oolefin monomer, wherein the reactor comprises a fluidized bed, an expanded section located at or near the top of the reactor, a distribution plate located at the lower part of the reactor and an inlet for a recycle stream located under the distribution plate, wherein the process comprises—feeding a polymerization catalyst to the fluidized bed in the area above the distribution plate—feeding the propylene and the optional at least one other oolefin monomer to the reactor—withdrawing the polypropylene from the reactor—circulating fluids from the top of the reactor to the bottom of the reactor, wherein the circulating fluids are compressed using a compressor and cooled using a heat exchanger, resulting in a cooled recycle stream comprising liquid, and wherein the cooled recycle stream is introduced into the reactor using the inlet for the recycl

Abstract: Disclosed in certain embodiments is an electron donor for a polyolefin polymerization catalyst. In some embodiments, a solid catalyst component includes a metal component and the electron donor that form a catalyst on a support.

Abstract: A Prepolymerized catalyst component for the polymerization of olefins comprising a solid catalyst component which comprises Mg, Ti, and chlorine atoms and an electron donor (ID) said prepolymerized catalyst component being characterized by the fact that: the electron donor (ID) is constituted by at least 80% mol of 1,3 diethers with respect to the total molar amount of electron donor compounds; the prepolymerized catalyst has a porosity due to pores with diameters up to 1 ?m of less than 0.2 cm3/g; it contains an amount of ethylene prepolymer of less than 45% with respect to the total weight of prepolymerized catalyst.

Abstract: An ethylene-?-olefin-based copolymer rubber which contains an ethylene unit and an ?-olefin unit having from 3 to 20 carbon atoms, and satisfies the following requirements (a) and (b) is provided. Requirement (a): a content of the ?-olefin unit is 50% by mass or more and 70% by mass or less when a sum of a content of the ethylene unit and the content of the ?-olefin unit is taken as 100% by mass. Requirement (b): a product of monomer reactivity ratios which is a product of a reactivity ratio of ethylene and a reactivity ratio of an ?-olefin is 0.70 or less and the product of monomer reactivity ratios is a value determined from a 13C-NMR spectrum.

Abstract: The present disclosure provides high density polyethylene resins having good low temperature impact resistance. The resins are suitable for use in rotomolding application for large parts. The resin is a bi- or trimodal resin produced using solution phase polymerization in the presence of a single site catalyst.

Abstract: An object of the present invention is to provide a curable resin composition having low viscosity and being capable of forming a cured product which is excellent in the flexibility and the heat resistance. The present invention is a curable resin composition including: a (meth)acrylic group-containing vinyl-based polymer (A), a monomer (B) represented by the following Chemical formula (1), and a radical initiator (C).

Abstract: A method for making a biodegradable ophthalmic lens includes steps of mixing poly[bis(methacrylate)phosphazene], hydrophilic monomers, and a photoinitiator to form a mixture; feeding the mixture into a mold, and heating or exposing the mixture to ultraviolet radiation, thereby causing the poly[bis(methacrylate)phosphazene] to function as a cross-linking agent. Such cross-linking agent undergoes a polymerization reaction with the hydrophilic monomers and the photoinitiator to form a polyphosphazenes hydrogel; and the polyphosphazenes hydrogel is then removed from the mold.

Abstract: One variation of a method for directly casting a thin layer onto a substrate includes: combining a prepolymer, a solvent, and a curing agent to define a viscous material; advancing a substrate from a roll across a surface continuously at a first speed; depositing the viscous material at a viscosity through a deposition head onto the substrate, the viscous material flowing laterally across the substrate to form a thin layer of substantially uniform thickness over the substrate over a period of time while the substrate advances along the surface; and, at a distance from the deposition head depositing the viscous material onto the substrate corresponding to a duration of time for the viscous material to flow laterally across the substrate, heating the viscous material to evaporate solvent and to induce reaction between the curing agent and the prepolymer to cure the viscous material to form a layer.

Abstract: The thermoplastic polyurethane compositions described herein have very good recovery properties, rebound resilience, or both, while also having good softness (i.e. low hardness). It has been difficult to provide thermoplastic polyurethane compositions with this combination of properties. Some compositions described herein also provide low haze and/or good clarity properties. These combination of properties make the thermoplastic polyurethane compositions described herein useful materials for application that require fast recovery, good rebound resilience, or both while also requiring soft materials, and in some embodiments low haze and/or good clarity.

Abstract: The present invention provides a curable composition excellent in curability and capable of forming, through light irradiation, a cured product excellent in light resistance, heat resistance, and transparency. The curable composition contains the following component (A), the following component (B), and the following component (C): the component (A): an alicyclic epoxy compound represented by the following formula (a): the component (B): a light resistance imparting agent having a maximum absorption wavelength in a region between 280 and 320 nm in an ultraviolet-visible light absorption spectrum from 250 to 400 nm; and the component (C): an optical cationic polymerization initiator: wherein R1 to R18 are the same as or different from one another and represent a hydrogen atom, a halogen atom, a hydrocarbon group that may contain an oxygen atom or a halogen atom, or an alkoxy group that may have a substituent; and X represents a single bond or a linking group.

Abstract: Disclosed are a highly functional natural material-derived epoxy resin, a preparation method therefor, and an epoxy resin curing composition using the same. The highly functional natural material-derived epoxy resin represented by chemical formula 1 is obtained by reacting a compound, represented by chemical formula 2, and epichlorohydrin (ECH), which is obtained by using glycerin as a starting material, in the presence of a hydroxide salt.

Abstract: Methods and formulations for distortional thermosets are disclosed that display enhanced composite mechanical performances and robust sorption resistance. The composition includes an epoxy resin of formula (I): and a diamine curing agent. The resultant distortional thermoset compositions possess superior out-life requirements and advantageous reaction kinetics for preparing prepreg compositions and materials.

Abstract: A process for producing cycloalkenamer-containing compositions involves converting at least one cycloalkene by ring-opening metathetic polymerization to obtain a polyalkenamer-containing product mixture. The product mixture is worked up to remove monomers and oligomers of the cycloalkenes to obtain the polyalkenamer-containing composition by extraction with CO2. The extraction involves at least two stages: an extraction with liquid CO2 under the supercritical conditions, and then an extraction with supercritical CO2. Such cycloalkenamer-containing compositions can be used, for example, in the field of packaging materials, especially for food and drink.

Abstract: A polymer compound having a constitutional unit represented by formula (1A) or formula (1B) and a constitutional unit represented by formula (2A) or formula (2B) is provided, wherein each of XM and XN is a crosslinkable group; and RAm, RBm, Ar1m to Ar5m, LM, ArM, m1 to m6, RAn, RBn, Ar1n to Ar5n, ArLn, LN, ArN, n1 to n6, and Ln are as defined in the specification. The polymer compound is excellent in crosslinkability and hole transportability.

Abstract: A method and compositions are described which improve extrusion- and creep-resistance of components for use in a high temperature applications including sealing elements and seal connectors among others. The method includes providing a composition having an aromatic polymer and a crosslinking compound, and subjecting the composition to a heat molding process to form the component and crosslink the aromatic polymer.

Abstract: The present invention relates to a method for preparing polylactic acid. According to the method for preparing polylactic acid, high quality polylactic acid can be provided by effectively removing residual monomers while minimizing property changes of the polylactic acid.

Abstract: The present invention refers to a formulation suitable for the manufacture of a pressure sensitive adhesive, said formulation comprising: a) 40-95 wt % of polyalkylene carbonate having a number average molecular weight higher than 17.000 Da; b) 5-60 wt % of a polyether carbonate polyol having CO2 groups randomly incorporated in the chemical structure thereof, wherein the content of CO2 ranges from 0.5 to 40 wt %, based on the total weight of the polyether carbonate polyol; and c) optionally, less than 30 wt % of a tackifying resin, provided that said formulation does not contain any reticulating agent.

Abstract: Described are a process for producing hydrosilylable polyoxyalkylene ethers, comprising the steps of (1) alkoxylation of at least one terminally unsaturated alcohol with alkylene oxides to afford a polyoxyalkylene ether, (2) etherification of the polyoxyalkylene ether from step (1) and (3) neutralization of the product from step (2) under buffered conditions, and hydrosilylable polyoxyalkylene ether mixtures.

Abstract: A photosensitive resin composition, a black pixel defining layer, and a display device, the composition including a binder polymer including a structural unit represented by Chemical Formula 1; a black colorant; a photopolymerizable monomer; a photopolymerization initiator; and a solvent,

Abstract: A transparent and colorless polyimide resin is provided. The polyimide resin is derived from at least two dianhydride monomers and at least two diamine monomers. At least one monomer in the dianhydride and diamine monomers includes structure of formula (1). The monomer with structure of formula (1) has an amount of moles accounting for 10-50% of total moles of the dianhydride or diamine monomers. In formula (1), X is SO2, C(CH3)2 or C(CF3)2, Y is oxygen.

Abstract: A polyamic acid according to an embodiment is formed by a polymerization reaction of a dianhydride compound, a first diamine compound represented by the following Formula 1, and a second diamine compound, which is different from the first diamine compound.