Patents Issued in August 16, 2018
  • Publication number: 20180228372
    Abstract: An apparatus for turbid sample measurement comprising a plurality of light sources for illuminating a turbid sample target area with non-spatial structured light, a projection system for illuminating the turbid sample target area with spatial structured light, a sensor for collecting light from the turbid sample target area, and a processor to analyze the data captured by the sensor to yield scattering and absorption coefficients of the turbid sample. A method comprises illuminating the sample with spatial structured light, collecting light reflected from the sample at a number of wavelengths, illuminating the sample with non-spatial structured light, collecting light reflected from the sample at a number of wavelengths, and combining the measurements of the collected light to obtain the optical properties of the sample and/or the concentration of absorbing or fluorescent molecules. The wavelengths of the spatial and non-spatial light sources are preferably different.
    Type: Application
    Filed: January 17, 2018
    Publication date: August 16, 2018
    Inventors: David Cuccia, Amaan Mazhar
  • Publication number: 20180228373
    Abstract: A scan head for scanning skin includes a frame and a camera coupled to the frame. A controllable probe is coupled to the frame and is configured to change an orientation of hair on the skin to be examined and imaged with the camera.
    Type: Application
    Filed: March 2, 2018
    Publication date: August 16, 2018
    Inventors: Mani Abedini, Rajib Chakravorty, Rahil Garnavi, Lenin Mehedy
  • Publication number: 20180228374
    Abstract: Optics for apodizing an optical imaging probe beam, and methods for fabricating optics for apodizing an optical imaging probe beam are provided. In some embodiments, optics for apodizing an electrical comprises: an optical fiber; a focusing element coaxially aligned with the optical fiber; an element having a cylindrical bore and an angled reflective surface, wherein a first portion of a beam focused by the focusing element enters the cylindrical bore and a second portion of the beam is reflected at an angle to produce a beam with a generally annular-shaped profile.
    Type: Application
    Filed: February 12, 2018
    Publication date: August 16, 2018
    Inventors: Dongyao Cui, Kengyeh K. Chu, Guillermo J. Tearney
  • Publication number: 20180228375
    Abstract: Provided herein is a method of optically recording neural activity in one or more regions of a target tissue. Also provided is a method of optically modulating the activity of a neural tissue. Further provided is a system that finds use in performing the present methods.
    Type: Application
    Filed: November 16, 2016
    Publication date: August 16, 2018
    Inventors: Christina K. KIM, Samuel J. YANG, Karl A. DEISSEROTH, Isaac V. KAUVAR
  • Publication number: 20180228376
    Abstract: A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.
    Type: Application
    Filed: April 11, 2018
    Publication date: August 16, 2018
    Inventors: Lior GREENSTEIN, Gilad A. DAVARA, Gad GANON, David AVIV
  • Publication number: 20180228377
    Abstract: An object information acquiring apparatus is provided, which includes: a light irradiator emitting with light at first and with light at second wavelength; a receiving unit receiving an acoustic wave and outputs a signal; a processing unit generating structural information and functional information; and a display controlling unit, wherein a first irradiation at the first wavelength, a second irradiation at the second wavelength, and a third irradiation at the first wavelength are performed, the receiving unit outputs first to third signals, the processing unit generates first functional information based on the first and second signals and generates second functional information based on the second and third signals.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 16, 2018
    Inventor: Naoto Abe
  • Publication number: 20180228378
    Abstract: A device for measuring blood measure measures variations in electrical charges on the body as a result of heart activity. A method using the same is also described. The method acquires ECG signal collected by a collection unit of the device for measuring blood measure, processes the ECG signal, extracts feature from the ECG signal, and computes blood pressure according to the feature extracted from the ECG signal.
    Type: Application
    Filed: July 19, 2017
    Publication date: August 16, 2018
    Inventor: KO-MAI LI
  • Publication number: 20180228379
    Abstract: A method of measuring blood pressure, including: sensing an atmospheric pressure, an applied pressure, and a blood pressure of a blood vessel delivered to a skin and outputting an electrical signal indicating a result of sensing the pressures; dividing the electrical signal into a divided electrical signal which includes a direct current (DC) signal and an alternating current (AC) signal; processing the divided electrical signal; calculating the applied pressure using the processed electrical signal; and calculating a blood pressure average using the calculated applied pressure and a swing value of the processed electrical signal.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Applicant: UMEDIX CORPORATION LIMITED
    Inventors: Sung Hun WOO, Yun Young CHOI, Yun Seok CHANG
  • Publication number: 20180228380
    Abstract: A method for determining a calibrated aortic pressure waveform from a brachial cuff waveform involves the use of one or more generalized transfer functions. The one or more generalized transfer functions are specific for predetermined brachial cuff pressure ranges, such as below diastolic pressure, between diastolic and systolic pressure, and above systolic pressure. The brachial cuff is inflated to a pressure within the pressure range appropriate for the generalized transfer function to be applied to the brachial cuff waveform to generate the aortic pressure waveform. In some circumstances, it may be necessary to use a calibration transfer function to generate a calibrated aortic waveform. In other circumstances, the calibration transfer function is not necessary.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Applicant: AtCor Medical Pty Ltd
    Inventor: Ahmad Qasem
  • Publication number: 20180228381
    Abstract: An earpiece monitor configured to be worn by a subject includes a battery, an earpiece fitting configured to be inserted within an ear canal of an ear of the subject, a reflective pulse oximeter configured to measure pulse rate and pulse intensity of the subject, a motion sensor configured to monitor footsteps and head motion of the subject, a digital memory for storing at least one algorithm, and a processor configured to process signals from the reflective pulse oximeter and the motion sensor using the at least one algorithm to generate as assessment of a health state of the subject. The earpiece fitting is configured to transmit sound to the inner ear or eardrum of the subject. The assessment of the health state of the subject may include an assessment of subject physiological stress and/or an assessment of overall subject health.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 16, 2018
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
  • Publication number: 20180228382
    Abstract: Systems and methods are provided for assessing patient blood flow using video image processing. According to one aspect, a method of analyzing at least one blood flow characteristic of a patient includes capturing a video including a plurality of frames of an arterio-venous (AV) fistula on the patient; amplifying motion in the video to produce a motion-amplified video; determining a difference in intensity between consecutive frames in the motion-amplified video to produce a time-function of an amplitude of the optic flow representing movement in an area of interest on the patient; and determining the at least one blood flow characteristic of the patient based on the time-function.
    Type: Application
    Filed: April 18, 2018
    Publication date: August 16, 2018
    Inventors: Peter Kotanko, Fansan Zhu
  • Publication number: 20180228383
    Abstract: Provided are a blood pressure measuring device, a blood pressure measurement method and a blood pressure measurement program that allow calculating blood pressure properly even for ambulatory users.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 16, 2018
    Inventors: Shinichi WARISAWA, Rui FUKUI, Haruyuki SANUKI
  • Publication number: 20180228384
    Abstract: A method for estimating blood pressure (BP) values comprises: measuring at a first PTT value, a second PTT value, and further PPT values using a method comprising measuring a first arterial pressure pulse arrival time (PAT) and measuring a second PAT value; calculating a PTT value from the difference between the first PAT value and the second PAT value; processing a sequence of electrical impedance tomography (EIT) images to identify at least one region of interest (ROI); and estimating at least one of the first and second PAT value from the variation of impedance value determined from the at least one ROI. The method allows for the non-invasive and continuous determination of the PB values by using a calibration factor.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 16, 2018
    Inventors: Josep Sola i Caros, Josef X. Brunner, Damien Ferrario, Andrew Adler, Martin Proenca
  • Publication number: 20180228385
    Abstract: An optical connector including a first optical fiber having a first diameter and having a core that includes a thermally expanded core portion adjacent a first end of the first optical fiber, a second optical fiber spliced to a second end of the first optical fiber, the second optical fiber having a second diameter less than the first diameter, and a connector bore having a first bore portion configured to receive the first end of the first optical fiber.
    Type: Application
    Filed: October 7, 2016
    Publication date: August 16, 2018
    Inventors: Michael J. Eberle, Diana Margaret Tasker, Howard Neil Rourke
  • Publication number: 20180228386
    Abstract: A patient monitor configured to receive patient-information electrical signals from an invasive patient sensor and a minimally invasive patient sensor, the patient monitor including a base unit and a detachable user interface unit for displaying hemodynamic parameters determined by the base unit. The base unit and user interface unit can be docked together, tethered together through a cabled connection, or physically separated from one another using wireless communication to transmit and receive information. The base unit and the user interface unit may pair before the user interface unit displays data to link the base unit with the user interface unit. The patient monitor can be configured to switch between invasive and minimally invasive monitoring of hemodynamic parameters of a patient, using invasive measurements to calibrate minimally invasive measurements.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Tom McCall, David Snider, Timothy John Hughes, Lina Derderian, James Cobb, Alison D. Burcar
  • Publication number: 20180228387
    Abstract: An intravascular system includes at least one pressure-sensing instrument sized and shaped for introduction into a vessel of a patient; a processing unit in communication with the pressure-sensing instrument, the processing unit configured to: obtain proximal pressure measurements for at least one cardiac cycle of the patient while the pressure-sensing instrument is positioned proximal of a stenosis of the vessel; obtain distal pressure measurements while the pressure-sensing instrument is positioned distal of the stenosis; select a diagnostic window within a cardiac cycle by identifying a change in sign of a slope associated with the proximal and/or distal pressure measurements, wherein the diagnostic window encompasses only a portion of the cardiac cycle of the patient; calculate a pressure ratio between the distal and proximal obtained during the diagnostic window; and output the calculated pressure ratio to a display device in communication with the processing unit.
    Type: Application
    Filed: July 15, 2016
    Publication date: August 16, 2018
    Inventors: Jinhyoung PARK, Fergus MERRITT
  • Publication number: 20180228388
    Abstract: A main body portion is shaped in a cylinder and formed with an intake port which is a hole through which air from an outside flows into the cylinder. The main body portion has one end, which is provided with one-way valve to impede inflow of air from the outside, and the other end, which is not provided with the one-way valve and through which the subject breathes. The resistance setting unit variably sets a magnitude of an inflow resistance to air flowing into the main body portion. The pressure measurement unit measures a pressure of air moving in the cylinder of the main body portion as the intraoral pressure.
    Type: Application
    Filed: July 12, 2016
    Publication date: August 16, 2018
    Inventors: Shinya KUROSAWA, Rie OSAKI, Kazuo TOKUSHIMA
  • Publication number: 20180228389
    Abstract: Systems and methods for determining prevalence of a cardiac phenomenon based on electrophysiological (EP) data from a tissue of a body are provided. The EP data is measured by at least one sensor disposed on at least one medical device that is positionable near the tissue of the body. A system includes an electronic control unit communicatively coupled to a display device and configured to, for each of the plurality of locations, detect, at each of a plurality of discrete times occurring during a predetermined time period, whether a cardiac phenomenon occurs at the location based on the EP data, determine a prevalence of the cardiac phenomenon based on the detecting, and display information indicative of the determined prevalence of the cardiac phenomenon on the display device.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 16, 2018
    Inventor: Srijoy Mahapatra
  • Publication number: 20180228390
    Abstract: A computer-implemented method for processing ECG data may include: receiving, over an electronic network, ECG data, wherein the ECG data represents a plurality of heartbeats; analyzing the ECG data, by at least one processor, to determine whether each of the plurality of heartbeats is a normal heartbeat or an abnormal heartbeat; associating, by the at least one processor, each of the abnormal heartbeats with either only one of a plurality of existing templates or a new template; receiving, from a user, input related to each new template, wherein the input includes either: a) a confirmation that the new template represents an abnormal heartbeat, or b) a reclassification of the new template as representing a normal heartbeat or a different abnormal heartbeat; and in response to the user input, updating, by the at least one processor, a label of each of the heartbeats associated with each confirmed new template and each of the heartbeats associated with each reclassified new template.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Applicant: InfoBionic, Inc.
    Inventors: Lev KORZINOV, Eric BAUMANN, Anna McNAMARA
  • Publication number: 20180228391
    Abstract: A method is provided for processing a neural measurement obtained in the presence of noise, in order to detect whether a locally evoked neural response is present in the neural measurement. A first neural measurement is obtained from a first sense electrode. A second neural measurement is contemporaneously obtained from a second sense electrode spaced apart from the first electrode along a neural pathway of the neural response. A neural response decay is determined, being a measure of the decay in the neural response from the first sense electrode to the second sense electrode. A ratio of the neural response decay to an amplitude normalising term is calculated. From the ratio it is determined whether a locally evoked neural response is present in the neural measurement.
    Type: Application
    Filed: November 17, 2015
    Publication date: August 16, 2018
    Applicant: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, Milan Obradovic
  • Publication number: 20180228392
    Abstract: A position sensor includes a flexible substrate formed into a three-dimensional (3D) shape. At least first and second field-sensing coils are formed in first and second respective layers of the flexible substrate, such that in the 3D shape the first and second field-sensing coils have first and second respective axes that are not parallel to one another.
    Type: Application
    Filed: February 15, 2017
    Publication date: August 16, 2018
    Applicant: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: ASSAF GOVARI, MEIR BAR-TAL, AVI REUVENI
  • Publication number: 20180228393
    Abstract: An electrophysiologic device may be constructed with an elongated body having proximal and distal ends a lumen. At least one coil may be formed around a distal portion of the elongated body from a plurality of helical wraps of a continuous wire that extends to the proximal end of the elongated body through the lumen. One or more coils may be provided and each may be configured to function as either a ring electrode or a location sensor.
    Type: Application
    Filed: February 15, 2017
    Publication date: August 16, 2018
    Inventors: Raymond Yue-Sing Tang, Anabel Haro
  • Publication number: 20180228394
    Abstract: Systems and methods for assisting a subject to voluntarily alter a brain state. One aspect of the method includes: (i) fitting the subject with equipment to monitor biologic data, the biologic data including a plurality of frequencies in a frequency range; (ii) requesting the subject retain the eyes in a normal open and blinking position for a second time period; (iii) monitoring biologic data during the second time period for the occurrence of a predetermined brain state; (iv) upon the detection of the predetermined brain state, presenting a stimulus to the subject, the stimulus designed to evoke an action performed by the subject; and (v) repeating steps (iii) and (iv).
    Type: Application
    Filed: October 20, 2017
    Publication date: August 16, 2018
    Applicant: Emtee Associates, L.P.
    Inventor: Michael Anselme Tansey
  • Publication number: 20180228395
    Abstract: An apparatus for detecting relative positioning of medical devices located within a human body, the apparatus comprising an inner elongate member comprising a plurality of electrodes and a first sensor member, where the first sensor member is located a known distance from each of the plurality of electrodes, and an outer elongate member comprising a first sensor, and an outer sensor member located between the first sensor and an inner wall of the outer elongate member, where the inner elongate member is configured to move within the outer elongate member and the first sensor is configured to sense a signal generated by movement of the inner elongate member relative to the outer elongate member, and a position detection module including an electronic control unit configured to detect a position of the first sensor member relative to the first sensor based on the signal.
    Type: Application
    Filed: February 13, 2018
    Publication date: August 16, 2018
    Inventors: Ryan K. Buesseler, Troy T. Tegg, Kevin Edmunds
  • Publication number: 20180228396
    Abstract: The biosensor of the present invention includes two or more electrodes and a support supporting the two or more electrodes. One or more of the electrodes each include a substrate having a metal surface, and a protective layer covering at least part of the surface. The protective layer is a continuous film made of carbon and having a thickness of at least 1 ?m.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Applicant: Toppan Printing Co., Ltd.
    Inventors: Toshikazu OKUBO, Ryo WARIGAYA, Masahiro KOSUGI, Kazuyo MINOWA
  • Publication number: 20180228397
    Abstract: A relay device (201) is described for relaying radio frequency signals received from an antenna implanted within a patient's body to another device located outside the patient's body, the relay device comprising a first slot antenna for detecting radio frequency signals sent from the antenna implanted within the patient's body and a second slot antenna for transmitting radio frequency signals to the other device located outside the patient's body, whereby the first and second slot antennas comprise elongated slots (209, 211) on opposite sides of a cavity (203). The signals to be transmitted by the second slot antenna are to be used to relay information conveyed by the signals detected by the first slot antenna. The relay device also comprises switching means (215, 217) for switching the first and second slot antennas between active and inactive configurations.
    Type: Application
    Filed: March 20, 2015
    Publication date: August 16, 2018
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventor: Sema DUMANLI OKTAR
  • Publication number: 20180228398
    Abstract: This disclosure concerns improved capabilities for evaluating whether additional medical tests need to be conducted for a diagnosis of a pulmonary arterial hypertension (PAH) condition in a patient. The method includes determining that the patient is at rest and measuring a partial pressure of carbon dioxide in a composite gas, comprising: transferring an expiration from the patient's mouth to a carbon dioxide analyzer; measuring end tidal carbon dioxide (EtCO2) from each of a plurality of oral expirations from the patient; and calculating a composite EtCO2 value. The method further includes comparing the composite EtCO2 value to a range of stored carbon dioxide partial pressure values; generating a signal indicating whether additional medical tests need to be conducted in response to the comparing; and providing the generated signal to an indicator, the indicator adapted to respond to the generated signal to provide an output in a human cognizable format.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Anna R. Hemnes, Alexander Newman, John Newman
  • Publication number: 20180228399
    Abstract: A capnograph device (10) includes a carbon dioxide measurement component (20) and an electronic processor (30) programmed to generate a capnogram (40) comprising carbon dioxide level sample values measured as a function of time. End-tidal carbon dioxide (etC02) is determined from the capnogram, and an etC02 parameter quality index (etC02 PQI) (44) is computed using one or more quantitative capnogram waveform metrics computed from the capnogram. A respiration rate (RR) value is also determined from the capnogram, and a RR PQI (46) computed using the RR value and the etC02 PQI. A respiratory well-being index (RWI) (50) may be computed from the etC02 and RR values and the etC02 and RR PQI values. In some embodiments the one or more capnogram waveform metrics are computed from a capnogram histogram generated from the capnogram.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 16, 2018
    Inventors: JOSEPH ALLEN ORR, LARA MARIE BREWER, PAUL BRUCE GUNNESON
  • Publication number: 20180228400
    Abstract: To provide a mask capable of reducing a load of a patient while suppressing lowering of accuracy at which a subject's exhaled air is measured. A mask to be put on a subject's face includes a mask body portion demarcating an internal space in a state of covering part of the subject's face and a cup-shaped nasal cup covering a subject's nose in a state of being arranged inside the internal space, in which the nasal cup includes a first wall portion covering the subject's nose, a second wall portion arranged under the subject's nostrils, and an exhaled air discharge portion guiding an exhaled air from the subject's nose to an exhaled air sensor, and at least part of the exhaled air from the subject's nose is guided toward the exhaled air discharge portion by the second guide portion in a state where the nasal cup covers the subject's nose.
    Type: Application
    Filed: February 13, 2018
    Publication date: August 16, 2018
    Inventors: Yuya Baba, Isao Matsubara, Masayuki Inoue, Kenichiro Kabumoto, Fumihiko Takatori
  • Publication number: 20180228401
    Abstract: A method and apparatus for generating a custom made orthotic or insole for footwear. Information relating to the pressure applied by the sole of a person's foot is used to custom produce an orthotic or insole for the person by using softer material or different structural components, selectively located at pressure points of a particular individual, to unload pressure on the foot at those points. Pressure readings taken for the foot of an individual identify pressure points for that foot. The pressure points are quantified and the foot is “mapped” in a grid format on a pressure map. Once mapped, structural components corresponding to a particular pressure value are positioned in the orthotic based on the mapping. The compression cells are created via 3D printing methods based on an individual's pressure readings and results from an electronic pressure plate utilizing pressure response sensors.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 16, 2018
    Inventors: Laurence SCHWARTZ, Evan SCHWARTZ
  • Publication number: 20180228402
    Abstract: A method, including performing an initial ablation of a tissue using an electrode in a probe distal end to apply a first power to the tissue, and measuring a change of temperature of the distal end while applying the first power. The method also includes estimating a thickness of the tissue in response to the measured change of temperature, and in response to the estimated thickness, computing at least one of a second power required and a time period for ablation, to complete ablation of the tissue. The method further includes performing a subsequent ablation of the tissue using the computed at least one of the second power and the time period for ablation.
    Type: Application
    Filed: January 11, 2018
    Publication date: August 16, 2018
    Inventor: Assaf Govari
  • Publication number: 20180228403
    Abstract: A posture monitoring apparatus, comprising: at least one processor; and at least one sensor configured to sense position and posture of a wearer of the device; wherein the at least one processor receives and processes input from the at least one sensor, and where necessary, indicates the wearer's posture needs correction, and operates an alarm module to signal the wearer to correct the wearer's posture; wherein the apparatus is worn above the shoulders of the wearer.
    Type: Application
    Filed: February 13, 2017
    Publication date: August 16, 2018
    Inventor: Conghua Li
  • Publication number: 20180228404
    Abstract: Various embodiments of a fall prediction system and method of using such system are disclosed. The system includes a hearing device for a wearer, a sensor operatively connected to the hearing device and adapted to detect a characteristic of the wearer and generate a sensor signal based on the characteristic, and a controller operatively connected to the hearing device. The controller is adapted to determine a fall risk value based on the sensor signal, compare the fall risk value to a fall risk threshold, and generate a fall prevention output if the fall risk value exceeds the fall risk threshold.
    Type: Application
    Filed: December 29, 2017
    Publication date: August 16, 2018
    Inventors: Sourav K. Bhunia, Justin R. Burwinkel, Jason A. Galster, Buye Xu, Peter J. Tetrick
  • Publication number: 20180228405
    Abstract: Various embodiments of a fall prediction system and method of using such system are disclosed. The system includes a hearing device for a user, a sensor operatively connected to the hearing device and adapted to detect a characteristic of the user and generate a sensor signal based on the characteristic, an accessory operatively connected to the hearing device, and a controller operatively connected to the hearing device. The controller is adapted to determine a fall risk value based on the sensor signal, compare the fall risk value to a fall risk threshold, and generate a fall prevention output if the fall risk value exceeds the fall risk threshold.
    Type: Application
    Filed: December 29, 2017
    Publication date: August 16, 2018
    Inventors: Justin R. Burwinkle, Sourav K. Bhunia, Jason A. Galster, Buye Xu, Peter J. Tetrick
  • Publication number: 20180228406
    Abstract: According to an embodiment of the present invention, a physical monitoring device is in the form of a necklace or pendant and includes an object (e.g., stone, gem, glass, crystal, or other transparent or translucent object that conveys light signals or color). The physical activity monitoring device includes one or more sensors to measure physical activity or motion of the user (e.g., steps, distance traveled by foot, body motion, etc.). The object is illuminated or changed to different colors to openly and outwardly indicate a level of physical activity of the user.
    Type: Application
    Filed: February 7, 2018
    Publication date: August 16, 2018
    Inventor: Steven M. Mendelsohn
  • Publication number: 20180228407
    Abstract: Provided is a system for hand rehabilitation comprising an enclosure comprising a top surface and a bottom surface opposite the top surface; a wrist support attached to the top surface and configured to support and rigidly hold a wrist in position with respect to the top surface; a finger retention support arranged on the top surface, sized to accommodate at least a fingertip, and arranged to allow the finger to exert forces on the finger retention support in any direction; a sensor housed within the enclosure and in communication with the finger retention support, the sensor configured to detect and convert forces exerted by the finger on the finger retention support in multiple degrees of freedom into an electrical signal; and a processor in electrical communication with the sensor and configured to receive the electrical signal and provide feedback to a user.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 16, 2018
    Inventors: Kevin C. Olds, Omar Ahmad, Promit Roy, John Krakauer
  • Publication number: 20180228408
    Abstract: An analyte monitoring system may include one or more sensors, one or more transceivers, one or more primary display devices, a remote computing device, and one or more secondary display devices. Each sensor may be in communication with a respective transceiver, and each transceiver may be in communication with a respective primary display device. A patient application may be stored as computer readable instructions in a storage medium of a primary display device, and an observer application is stored as computer readable instructions in a storage medium of a secondary display device. The patient application may be configured to allow a user of the primary display device to share analyte information with a secondary display device. The observer application may be configured to allow a user of the secondary display device to receive and display the shared analyte information.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 16, 2018
    Applicant: Senseonics, Incorporated
    Inventors: Barkha Raisoni, Barbara Montgomery, Andrew Dehennis
  • Publication number: 20180228409
    Abstract: Disclosed in an embodiment is an operating method of portable apparatus for noninvasively measuring blood glucose levels. The method includes: (a) measuring a first signal value according to ambient environmental light when an LED for measuring signals which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to light which is scattered by or transmitted through subject tissue and enters a photodetecting unit when the LED for measuring signals is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) adjusting the quantity of the light radiated from the LED for measuring signals by feeding the difference between the glucose concentration measurement and a pre-established first reference value back to the driving current for the LED for measuring signals.
    Type: Application
    Filed: February 12, 2017
    Publication date: August 16, 2018
    Inventor: Hoon KIM
  • Publication number: 20180228410
    Abstract: Presented are systems and methods that perform noninvasive glucose monitoring using mid-infrared self-emission of the human body that acts as a background radiation emitter. Various embodiments accomplish this by taking advantage of the guided-mode resonance (GMR) effect in a number of bandpass filters that are constructed as an array of coplanar filters. The filter array acts as a spectral separator that uses a grating layer and a thin film waveguide to form reflection and transmission filters for particular wavelengths. Unlike, common multi-layer optical filter designs that utilize numerous individual optical filters, a novel GMR filter design comprises an array of filters that may be fabricated from CMOS-compatible materials using only a few thin film and grating layers to filter light. Advantageously, this reduces manufacturing cost and allows for simultaneous monitoring of a number of wavelengths of the glucose spectrum.
    Type: Application
    Filed: February 6, 2018
    Publication date: August 16, 2018
    Inventors: Yen-Chun Yeh, Sheng Yang, Dominik J. Schmidt
  • Publication number: 20180228411
    Abstract: Various embodiments of the invention provide systems and methods for low-cost, low-power Array Waveguide Grating (AWG)-based miniaturized Raman spectroscopy for use in non-invasive glucose monitoring systems, such as in wearable devices that require no replenishment of chemicals or enzymes. The AWG may be manufactured using VLSI processing technology, which significantly reduces manufacturing cost and replaces holographic grating as the dispersive component of light. In embodiments, the AWG is integrated with a number of PIN photodiode detectors on a substrate to further reduce cost and signal loss. In embodiments, a prism-coupling method eliminates alignment problems associated with traditional approaches that utilize fiber-coupling methods.
    Type: Application
    Filed: February 6, 2018
    Publication date: August 16, 2018
    Inventors: Sheng Yang, Yen-Chun Yeh, Dominik Schmidt
  • Publication number: 20180228412
    Abstract: A transmission-mode optical spectroscopy method includes illuminating a first face of a skinfold with first light having plural wavelengths and detecting second light that emerges from a second face of the skinfold. The skinfold has a thickness of less than 1.5 millimeters.
    Type: Application
    Filed: February 7, 2018
    Publication date: August 16, 2018
    Inventor: Craig M. Gardner
  • Publication number: 20180228413
    Abstract: Provided is a method for measuring blood glucose levels of a subject with a portable apparatus for noninvasively measuring blood glucose levels including at least one light receiving element for detecting light by using different light integration times, including: (a) switching on an LED for emitting light having wavelength absorbed in or scattered by glucose; (b) measuring a first signal value according to light which is reflected off the surface skin layer of the subject and enters in response to a first light integration time in the situation where the light is radiated; (c) adjusting a second light integration time for measuring light reflected off the inner skin layer of the subject based on the first signal value; (d) measuring a second signal value according to the light which is reflected off the inner skin layer of the subject and enters in response to the adjusted second light integration time; and (e) producing the blood glucose level of the subject by using a third signal value according to light
    Type: Application
    Filed: February 12, 2017
    Publication date: August 16, 2018
    Inventor: Hoon KIM
  • Publication number: 20180228414
    Abstract: This relates to an electronic device configured for optical sensing having shared windows and including light restriction designs. The light restriction designs can include one or more of optical layers, optical films, lenses, and window systems configured to reduce or eliminate crosstalk between optical components. A plurality of accepting sections and a plurality of blocking sections can be employed to selectively allow light having an angle of incidence within one or more acceptance viewing angles and block light with angles of incidence outside of the acceptance viewing angles. In some examples, the light restriction designs can include variations in optical and structural properties can allow the light restriction designs to have spatially varying acceptance angles. Variations in structural properties can include, but are not limited to, differences in widths, heights, and/or tilts of the accepting sections and/or blocking sections.
    Type: Application
    Filed: January 18, 2018
    Publication date: August 16, 2018
    Inventors: Guocheng SHAO, Mathieu CHARBONNEAU-LEFORT, Ueyn L. BLOCK
  • Publication number: 20180228415
    Abstract: A system for sensing glucose concentration is provided and includesZZ following components. A light source generates a light beam. The system may include a polarization state generator (PSG) for changing the polarization of the light beam, and then the light beam is emitted to a biological tissue. A polarization state analyzer (PSA) receives the light beam reflected from the biological tissue, and the received light beam is used to calculate Stokes vectors. A Mueller matrix is calculated according to the Stokes vectors. In some embodiments, the system includes an optical coherence tomography (OCT) in which the light beam is sensed by a detector for calculating the Mueller matrix. An optical rotation angle and a depolarization index are calculated in accordance with the differential Mueller matrix formalism. The glucose concentration is calculated in accordance with the optical rotation angle and the depolarization index.
    Type: Application
    Filed: January 4, 2018
    Publication date: August 16, 2018
    Inventors: Yu-Lung LO, Quoc-Hung PHAN, Chia-Chi LIAO
  • Publication number: 20180228416
    Abstract: Various examples are described for needle alignment for wearable biosensors. One example device includes a housing comprising an upper portion and a lower portion, the housing defining a cavity between the upper portion and the lower portion and configured to be worn on a wearer's skin, wherein: the upper portion defines a first opening extending through the upper portion to the cavity, and the lower portion defines a second opening extending through the lower portion to the cavity, the cavity establishing a substantially unobstructed pathway including the first opening and the second opening to enable an insertion needle to be inserted through the housing; and a needle guide extending into and along a portion of the pathway and aligned with a sensor wire to enable alignment between the insertion needle and the sensor wire.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 16, 2018
    Applicant: Verily Life Sciences LLC
    Inventor: Sean Frick
  • Publication number: 20180228417
    Abstract: An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle. The needle is optionally removed and blood dispensed from the body into a test or collection device by actuating the ejector.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 16, 2018
    Inventors: John Richard Sink, Jasper N. Pollard, Gustavo Pena, Deborah Asion, Mitchell Hockett, Joy Parr Drach, Martha Payne, David A. Calderwood
  • Publication number: 20180228418
    Abstract: Various collection devices, systems and methods relating to the use of devices with open microfluidic channels disposed within a housing defining a lumen. These devices make use of microneedles passed through apertures to induce fluid flow into microfluidic channel networks for collection and analysis. The device can be actuated via button when placed on the skin of a patient to collect a fluid sample, such as a blood draw.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Inventors: Erwin Berthier, Ben Casavant, Ben Moga
  • Publication number: 20180228419
    Abstract: Over 350 million people worldwide suffer from depression, a third of whom are medication resistant. Seizure therapy remains the most effective treatment in depression, even when many treatments fail. The utility of seizure therapy is limited due to its cognitive side effects and stigma. The biological targets of seizure therapy remain unknown, hindering design of new treatments with comparable efficacy. Seizures impact the brains temporal dynamicity observed through electroencephalography. This dynamicity reflects richness of information processing across distributed brain networks subserving affective and cognitive processes. We investigated the hypothesis that seizure therapy impacts mood (depressive symptoms) and cognition by modulating brain temporal dynamicity. We obtained resting-state EEG from thirty-four patients (age=46.0±14.0, 21 females) receiving two types of seizure treatments—electroconvulsive therapy or magnetic seizure therapy.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 16, 2018
    Inventor: Faranak Farzan
  • Publication number: 20180228420
    Abstract: Provided is a system for monitoring a state of a user. The system includes a chair including a backrest and a seat plate, at least one flexible tactile sensor positioned in the back plate or seat plate and configured to sense a motion of a user who sits on the chair. The system further includes a monitoring apparatus configured to monitor the state of the user based on the sensed value received from at least one flexible tactile sensor.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Kunnyun KIM, Kwang Bum PARK, Won Hyo KIM, Yeon Hwa KWAK
  • Publication number: 20180228421
    Abstract: Disclosed are methods for detecting neuronal oscillation in the spinal cord of a subject. The methods can be utilized to determine that the subject has a disease or disorder of the spinal cord. The methods are useful for treating or reducing the likelihood of pain in a subject by detecting neuronal oscillation in the spinal cord and, e.g., administering a therapeutic agent to the subject. The electrode (LFP) methods disclosed herein may also be utilized to screen for a therapeutic agent that decreases neuronal oscillation in the spinal cord using a non-human animal subject.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 16, 2018
    Inventor: Carl SAAB