Abstract: Systems and methods including a device having integrated sensor arrays constructed and configured to measure and analyze multiple biosignatures concurrently in real time and a mobile application to control the device, process data, and transmit data wirelessly via at least one network to at least one remote computing device for analyzing the multiple biosignatures and cross-correlation with at least one external factor resulting in the creation of personal and situation profiles for continued on-going real time monitoring, refinement, alerting, and action recommendations.

Abstract: An intracranial pressure monitoring device includes a housing defining a first internal chamber, a plurality of strain gauges disposed on an inner surface of a diaphragm defined by a wall of the first internal chamber, a device for generating orientation signals, and circuitry coupled to the plurality of strain gauges and to the device. The circuitry is configured to generate intracranial pressure data from signals received from the plurality of strain gauges, generate orientation data based on the orientation signals received from the device, and store the intracranial pressure data and the orientation data in a computer readable storage such that the intracranial pressure data and orientation data are associated with each other.

Abstract: An electrocardiogram analyzing method includes: (a) acquiring electrocardiogram data representing an electrocardiogram waveform having heart beat waveforms; (b) acquiring RR interval data from the electrocardiogram data; (c) detecting at least one premature ventricular contraction causing a compensatory pause; (d) extracting, from the RR interval data, RR intervals during the detected premature ventricular contraction and before and after the detected premature ventricular contraction; (e) extracting a first RR interval group and a second interval group respectively from the RR intervals, wherein the first interval group includes the intervals before the premature ventricular contraction, and the second interval group includes the intervals after the premature ventricular contraction; (f) performing a predetermined frequency analysis on the first RR interval group; (g) performing the frequency analysis on the second RR interval group; and (h) comparing a first analysis result obtained by the step (f) and a se

Abstract: An emergency cardiac and electrocardiogram (ECG) electrode placement device is disclosed herein. The emergency cardiac and electrocardiogram (ECG) electrode placement device incorporates electrical conducting materials and elastic material into a pad that is applied to a chest wall of a patient, which places multiple electrodes in the appropriate anatomic locations on the patient to quickly obtain an ECG in a pre-hospital setting.

Abstract: An apparatus for guiding a biomedical electrode is provided, which guides a biomedical electrode to be brought into close contact with a living body surface of a voluntary muscle into optimum close contact positions on the basis of positions of the voluntary muscle and a neuromuscular junction of the voluntary muscle inside the living body surface. The relative positions of the voluntary muscle and the neuromuscular junction of the voluntary muscle to the living body surface are detected from muscle action potentials detected by myoelectric detection electrodes put into close contact with a large number of positions on the living body surface. On the basis of the relative position information, a close contact position of the biomedical electrode to be brought into close contact with the living body surface of the voluntary muscle is guided to an optimum position.

Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The wearable monitor sits centrally (in the midline) on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and, to a lesser extent, the QRS interval signals indicating ventricular activity in the ECG waveforms. Additionally, the monitor recorder includes an ECG sensing circuit that measures raw cutaneous electrical signals and performs signal processing prior to outputting the processed signals for sampling and storage.

Abstract: A post-processing leakage correction system and method that accounts for bidirectional contrast agent transport between the intravascular and interstitial spaces that commonly occurs in angiogenic high-grade gliomas without a substantial increase in post-processing computation time.

Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: Methods, apparatuses, and systems to differentiate adipose tissue from scar tissue are disclosed. One or more electrophysiology data points, each of which includes an electrophysiological signal associated with a tissue location that possesses certain signal characteristics, can be collected. An adipose tissue probability and/or a scar tissue probability can be computed using the characteristics of the electrophysiological signal, such as signal duration, signal amplitude, signal fractionation, and/or late potentials. The probability computation can also utilize dielectric properties, such as tissue impedance, tissue conductivity, and/or tissue permittivity, measured at the tissue location. Graphical representations of the adipose tissue probability and/or scar tissue probability can also be output.

Abstract: A breath sensor including a main body into which breath can be introduced, a conversion section for converting a gas component contained in the breath to a specific component, and a sensing section for detecting the specific component. The sensing section constitutes a first unit including an integrated detection element and a first heater. The conversion section constitutes a second unit including an integrated catalyst and a second heater. The first unit and the second unit are disposed inside the main body so as to be separated from each other with a gap therebetween, or are in contact with each other via a heat insulating member. The first unit and second unit are in communication with each other through a pipe that allows the breath to pass therethrough, and the pipe is partially bent.

Abstract: A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ECG signal from a patient and a monitored ECG signal from the patient. The memory may be in electrical communication with the heart monitor and adapted to store a plurality of baseline statistical characteristics of the baseline ECG signal and a plurality of monitored statistical characteristics of the monitored ECG signal. The processor may be in electrical communication with the memory and adapted to compare the plurality of baseline statistical characteristics to the plurality of monitored statistical characteristics and determine a likelihood of patient match. The heart monitor may be configured for further collection of the monitored ECG signal if the likelihood of patient match is greater than a threshold level.

Abstract: A system and method are described herein for a sensor device which biomechanically detects in real-time a user's movement state and posture and then provides real-time feedback to the user based on the user's real-time posture. The feedback is provided through immediate sensory feedback through the sensor device (e.g., a sound or vibration) as well as through an avatar within an associated application with which the sensor device communicates. The sensor device detects the user's movement state and posture by capturing data from a tri-axial accelerometer in the sensor device. Streamed data from the accelerometer is normalized to correct for sensor errors as well as variations in sensor placement and orientation. Normalization is based on accelerometer data collected while the user is wearing the device and performing specific actions.

Abstract: Systems and methods provided relate to patient sensors and/or patient monitors that recognize and/or identify a patient with physiological signals obtained from the sensor. A scalogram may be produced by applying a wavelet transform for the physiological signals obtained from the sensor. The scalogram may be a three dimensional model (having time, scale, and magnitude) from which certain physiological information may be obtained. For example, unique human physiological characteristics, also known as biometrics, may be determined from the scalograms. More specifically, monitoring the changes in the morphology of the photoplethysmographic (PPG) waveform transforms (e.g., scalogram) may determine patient-specific information that may be used to recognize and/or identify the patient, and that may be used to determine a proper or improper association between the patient and the wireless sensor and/or patient monitor.

Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

Abstract: The present disclosure relates to a dialysis device (1), more particularly a microdialysis device for the sampling of substances from the surface of a body organ. The device is particularly useful in the context of the monitoring of a moving organ, such as a beating heart, as the device comprises attachment means (2) allowing for a flexible and reliable attachment thereto. Furthermore, the microdialysis device provides for an efficient exchange of substances, such as metabolic substances, between the organ and the dialysis fluid through a semi-permeable material forming part of the device. There is also provided a method encompassing the device of the disclosure.

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Abstract: Systems and methods for comparing a first patient's pulse oximeter data with a second patient's pulse oximeter data. The system of the present invention comprises a pulse oximeter device and a remote server. The method of the present invention comprises acquiring a first patient's pulse oximeter data and inputting one or more markers for various segments of the first patient's acquired pulse oximeter data. A second patient's pulse oximeter data corresponding to a known condition may be displayed with the first patient's pulse oximeter data and the one or more markers to aid the medical personnel in diagnosing the first patient's condition. After diagnosis, the first patient's pulse oximeter may also be simplified to allow the first patient to understand the pulse oximeter data.

Abstract: A wearable optical device is described for optically detecting parameters of interest within muscle, such as during physical activity or when at rest. The parameters of interest include oxygenation level and/or hemoglobin concentrations in some situations. The detected parameters, such as oxygenation level, may be used to assess physical performance, such as the extent to which the muscle is utilizing aerobic or anaerobic processes. Methods for determining the parameters of interest, such as oxygenation level, from the detected optical signals are also described, and feedback may be provided to a user.

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

Abstract: The stress detection and management includes a human interface device having a mouse portion to generate cursor control signals and a stress detection portion. The stress detection portion includes a plurality of sensor probes to detect a user's electrical skin response to stress. A sensor is coupled to the plurality of sensor probes to generate a voltage indicative of the skin response to stress. A neural network, coupled to the sensor, generates a stress classification indication based on the voltage indicative of the skin response and pre-training of the neural network with stress indications. The neural network is retrained by comparing the baseline stress classification with the user inputs, using heuristic rules.

Abstract: The present disclosure refers to a multifunction device for the measurement of the strain on the faces of load cells and displacement on the free ends of load cells. This way, it is possible to measure the traction and/or compression force and energy expended by a muscle or muscle groups of the human body. The present disclosure allows also to determine the force profile, the instantaneous power and the average power. The present disclosure also relates to a device for the measurement, recording and digital monitoring of the evolution of force and respective expended energy.

Abstract: The invention concerns observation, measurement and analysis of a person's eye movements while viewing a screen, for purposes of evaluating brain health, eye coordination or level of ability of a person for various pursuits such as sports.

Abstract: A device (10) for performing an allergy test comprising a container unit (11) having a first surface (12) and a second surface (13). The container unit (11) comprising a plurality of cavities (22) each arranged for receiving an allergen container (14) comprising a supporting material (18) and a pricking tool, which is secured at a location of the supporting material (18). The supporting material (18) is arranged, when a pressure force is applied on the second surface (13), for being compressed thereby causing the pricking tool (19) for being displaced from a first position (25), wherein at said first position the at least one pricking tip (24) is at a first distance from the first surface (12), to a second position (26), wherein at said second position (26) the at least one pricking tip (24) is at a second distance from the first surface (12).

Abstract: The disclosure concerns a medical kit arranged with componentry for fluorescein sodium (FNa)-based diagnosis and trichloroacetic acid (TCA)-based treatment of neoplastic tissue, and related methods for utilizing aspects of the medical kit.

Abstract: One variation of a system for tracking and responding to Sun exposure includes: a housing configured to transiently attach to a port on a first garment; a jack coupled to the housing configured to transiently engage a port on the first garment; a radiation sensor arranged in the housing and configured to detect solar radiation incident on the housing; and a controller configured to: read an identifier of the first garment from the port via the jack; based on the identifier, estimate a skin exposure of a user wearing the first garment; read an solar radiation value from the radiation sensor at a first time; and, based on the solar radiation value and the skin exposure, estimate an solar radiation exposure of the user at the first time.

Abstract: A system and a method predict risk of diabetic foot ulcer by automatically recognizing and tracking physiological activities of a person using a smart textile that has a plurality of pressure sensors and a plurality of temperature sensors. Pressure data indicative of plantar pressure applied to each of the pressure sensors by the person is received from the smart textile. Temperature data indicative of plantar temperature at each of the temperature sensors is received from the smart textile. Plantar parameters are determined from the pressure and temperature data and plantar responses to activity of the person are determined from the plantar parameters. A risk of the person developing a foot ulcer is determined based upon the plantar parameters and the plantar responses.

Abstract: Provided is a non-invasive system and method for determining a fuel value for a target muscle and potentially at least one indicator muscle. The method includes receiving an ultrasound scan of a target muscle; evaluating at least a portion of the ultrasound scan to determine fuel value within the target muscle; recording the determined fuel value for the muscle as an element of a data set for the muscle; evaluating the fuel data set to determine a value range; and in response to the range being at least above a pre-determined threshold, establishing a target score for the muscle as based on an upper portion of the value range. The method may be repeated to identify ranges for a plurality of muscles, the muscle with the greatest range being identified as an indicator muscle. Based on these findings the muscles estimated fuel level, fuel rating and energy status may be determined. An associated system is also disclosed.

Abstract: Consultation advice based on ongoing user monitoring is provided. In various embodiments, first physiological data of a user is collected by a wearable device for a first time period. From the first physiological data individualized physiological data statistics are determined. The individualized physiological data statistics are stored. Second physiological data of the user are collected by the wearable device for a second time period. The second physiological data are compared to the individualized physiological data statistics to detect an abnormality. The user is notified to seek medical attention.

Abstract: A method is disclosed comprising: causing, at least in part, providing or providing an activity information indicative of an activity to be performed by a user, obtaining user activity information, wherein the user activity information is indicative of at least one inclusion criterion, at least one exclusion criterion, at least one controlling criterion, or a combination thereof, wherein at least a first part of the user activity information is gathered by a sensor and at least a second part of the user activity information is received by user input, determining, using a processor of the at least one apparatus, an adaptation of the activity information based on the user activity information, outputting the activity information. It is further disclosed an according apparatus, computer program and system.

Abstract: An activity meter (100) includes (i) a sleep level judging section (112) for repeatedly detecting a sleep level of a user and (ii) a notifying section (113) for automatically notifying the user of specific information only during a period during which a most recent sleep level is less than a predetermined level.

Abstract: A monitor recorder optimized for electrocardiography and respiratory data acquisition and processing is provided.

Abstract: The present invention relates to a device for accurately estimating the energy expenditure of a person, in particular by which the effect of cardiovascular drift is taken into account. The device comprises an input unit (10) for obtaining a movement signal (13) representing physical activity of the person and a heart rate signal (15) representing the heart rate of the person, a cardiovascular drift determination unit (16) for determining cardiovascular drift phases (17) from said movement signal (13) and either said heart rate signal (15) and/or one or more cardiovascular drift related signals (23) carrying information on one or more of amount of sweat, weight loss, temperature rise, blood lactate concentration and physical fatigue of the person, a correction unit (18) for correcting the heart rate signal (15) generated and representing the heart rate during a cardiovascular drift phase, and an estimation unit (20) for estimating the energy expenditure of the person from the corrected heart rate signal (19).

Abstract: A wearable paper-based platform with simultaneous passive and active feedback for monitoring perspiration is provided. The sensor platform comprises two modules: a disposable wicking-based sweat collection patch with discrete colorimetric feedback, and a reusable electronic detachable module for active feedback. The disposable patch comprises a hygroscopic wicking material laminated between two polymeric films. The wicking material is patterned with a radial finger design that offers discretized visual readout of the sensor. The active module attaches to the film and alerts the user when the film collects a pre-determined volume of sweat. The multi-feedback system allows high-performance athletes who value objective quantification of perspiration to better assess their sweat loss during physical activities.

Abstract: This invention provides systems and methods for using spatially localized sensor data to construct a multi-dimensional map of the location of key anatomical features, as well as systems and methods for utilizing this map to present location-based information to the surgeon and/or to an automated surgical navigation system. The location map is updated during surgery, so as to retain accuracy even in the presence of muscle-induced motion or deformation of the anatomy, as well as tissue location changes induced by translations or deformations induced by surgical dissection, surgical instrument contact, or biologically-induced tissue motion associated with activities such as respiration, anesthesia-induced gag reflex, blood flow/pulsation, and/or larger-scale changes in patient posture/positioning.

Abstract: This invention provides a system and method for performing a surgical procedure that effectively locates and allows a user to avoid engagement with hidden nerves in tissue in real-time. The system and method employs an integrated stimulating and sensing array. The array includes a plurality of spaced-apart electrodes, which are selectively stimulated while the electrodes then sense for a neural response. Each of the electrodes is stimulated to map of the sensed tissue region for localization of nerve paths. This localization can be stored and used to control cutting of tissue. The locations can be marked as nerve-free and/or no-go regions so as to avoid nerve-containing regions in subsequent procedures or following a stimulation procedure. This marking can be by any acceptable physical and/or virtual fiducial mechanism. The array can be a single structure with all relevant electrodes or some electrodes can be provided in a separate, remote probe assembly.

Abstract: The invention relates to a sensor module for body parameters and to a method for transmitting, receiving, and storing information about the behavior of a user during sport, movement, and at rest. Said information is determined from at least one of various biometric sensors, GPS chips, girometers, and others, location, speed, movement and other devices (measuring devices) measuring at least one status or a status change. The information is then transmitted by means of at least one radio chip connected to the measuring device, wherein the measuring devices are not networked with or connected to one another, but the transmission is rather carried out directly from the respective measuring device and radio chip, the measuring module, to one or more servers, preferably by means of mobile interne, mobile telephone data link, or another radio link.

Abstract: The disclosure provides a wireless biometric monitoring system that may be capable of acquiring, compiling, analyzing, and transmitting biometric data in near real time/real time. The system may utilize either the most up-to-date Bluetooth protocol (currently Bluetooth Smart) or a similar wireless protocol. The system may further integrate through this wireless protocol with peripheral devices to expand the measurement capacity of the system. In embodiments, the system may be capable of monitoring multiple biometric responses including, but not limited to: skin temperature, core temperature, respirations, heart rate, predicted tidal volume, chest wall movement, abdominal movement in conjunction with inspiration, abdominal movement in conjunction with expiration, HRR (heart rate reserve), HRV (heart rate variability), body position relevant to perpendicular, shoulder position relevant to hip position, general body posture, up time, down time, and malfunctions.

Abstract: A monitoring device suitable for attachment to a surface of a subject, the device having a data collector and a processor. The data collector includes a flexible foil attached to a less flexible socket, where the foil forms a dermal side surface of the data collector for adhesion to a skin surface of a subject to be monitored. To enable communication of electrical signals between the data collector and the processor, the data collector includes a distribution structure formed as a pattern of an electrically conductive material on an outer surface of a foldable sheet. The foldable sheet forms a layer in the flexible foil and having an interface portion which is folded into an aperture in the socket to form a coupling inside the cavity for electrical communication with a matching coupling of the processor when the processor is received in the cavity.

Abstract: Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

Abstract: The invention is directed to a mapping catheter, more particularly to a high resolution mapping catheter for mapping the atrial endocardium in high resolution in order to provide information on the propagation of the electrical signals to treat atrial fibrillation. The catheter is mainly configured for mapping, but—if required—may also be used for ablation, for stimulation and for cardioversion.

Abstract: The present disclosure facilitates capture (e.g., bipolar capture) of differentially-acquired wide-band phase gradient signals (e.g., wide-band cardiac phase gradient signals, wide-band cerebral phase gradient signals) that are simultaneously sampled. Notably, the exemplified system minimizes non-linear distortions (e.g., those that can be introduced via certain filters such as phase distortions) in the acquired wide-band phase gradient signals so as to not affect the information therein that can non-deterministically affect analysis of the wide-band phase gradient signal in the phase space domain. Further, a shield drive circuit and shield-drive voltage plane may be used to facilitate low noise and low interference operation of the acquisition system.

Abstract: A method and system for low-distortion denoising of an ECG signal are disclosed. The method comprises determining at least one beat of the ECG signal for denoising using a beat selection logic and denoising the at least one beat using at least one ensemble averaging filter. The system includes a sensor to detect the ECG signal, a processor coupled to the sensor, wherein the processor includes a beat selection logic unit, and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to determine at least one beat of the ECG signal for denoising using a beat selection logic and to denoise the at least one beat using at least one ensemble averaging filter.

Abstract: According to an example aspect of the present invention, there is provided an apparatus comprising two charge amplifiers configured to receive input from an acceleration sensor and to each produce one first output signal, a differential amplifier configured to receive the first output signals and to amplify a difference between the first output signals to produce two second outputs signals.

Abstract: Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

Abstract: A system that detects heartbeats includes a sensor or a transducer and algorithms based on deep learning. The algorithms employ techniques of artificial intelligence that enable the system to extract heartbeat features under low signal-to-noise-ratio (SNR) conditions when a user is exercising. The algorithms can be applied to various technologies for heart rate monitoring such as ultrasound Doppler, photoplethysmogram (PPG), electrocardiogram (EKG), acoustic, pressure/force sensing and laser/RF Doppler, among other types of sensing methods.

Abstract: A method and apparatus for the quantitative determination of an individual's risk for sudden cardiac death (SCD) is described. Risk determination is accomplished and may have a sensitivity and specificity of greater than 95%, by generating linear and nonlinear mathematical digital ECG-constructed models from digital ECG-type data of an individual's digital ECG, determining stability/instability of digital ECG-constructed control model systems corresponding to the digital ECG-constructed models by a plurality of techniques and transforming stability/instability values obtained by the determining stability/instability into a quantitative value reflecting an individual's risk for SCD.

Abstract: Systems and methods to track and manage individualized redox homeostasis are described. Tracking individualized redox homeostasis detects an increased risk of injury and/or illness thereby allowing appropriate interventions to reduce this risk.

Abstract: Devices (100), systems (200), and methods for automatically evaluating a potential stroke condition in a subject are disclosed and described.

Abstract: This information processing device selects a sensor to be controlled according to the activity plan of a user. The information processing device is attached to the user's body. The information processing device is provided with: a plurality of sensors; an acquisition means for acquiring an activity plan of the user; and a control means that selects a sensor to be controlled from among the plurality of sensors on the basis of the acquired activity plan. The control means activates the sensor suited for the activity plan from among the plurality of sensors and inactivates sensors that are not suited for the activity plan from among the plurality of sensors.