Abstract: A method for selectively powering a battery-operated drug-delivery device, the device having a battery and a battery circuit, the method comprising: providing a battery isolator in a first position whereat it interrupts a battery circuit, whereby no power is provided to the device; and activating a fastening mechanism configured for fastening the device to a user, the activating causing the battery circuit to be uninterrupted by the isolator, such that power is provided to the device. Additionally, there is provided a selectively powered battery-operated drug-delivery device, comprising: a selectively-removable isolator disposed in a first position whereat it interrupts a battery circuit; the isolator movable to a second position whereat the battery circuit is uninterrupted by the isolator; and a mechanism for fastening the device to a user, activation of the fastening mechanism moving the isolator from the first position to the second position.

Abstract: Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.

Abstract: A variable flexibility adhesive system may adhere a surface of a medical infusion device to the skin of a user. The system may be configured to hold a location on the surface stationary with respect to a site on the user's skin. The system may include an adhesive substrate for adhering to the user and an interface where the substrate is held to the surface of the device. The interface may totally and/or partially surround the stationary location. A skirt of the substrate may totally and/or partially surround the interface. Parts of the skirt may be stiffened. Optional features may include tabs for activation of the adhesive and/or a location for peeling the infuser away from the skin. Additionally or alternatively, the interface may have variable flexibility. Additionally or alternatively, the stiffener may include a plastic layer.

Abstract: Embodiments of the invention provide multi-stage biodegradable drug delivery platforms and methods for the subcutaneous delivery of therapeutic agents (TA). Embodiments of the platform may be configured to subcutaneously deliver a first dose of a first TA which is absorbed into the body and/or blood stream (BBS) to produce a first therapeutic effect for a first selectable time period (STP), and subsequently after a second STP, deliver a second dose of a second TA which is absorbed into the BBS to produce a second therapeutic effect for a third STP. An embodiment of the platform may comprise a body having a tissue-penetrating end, a primary cavity having a first TA dose and a shell having a secondary cavity having a second TA dose. The first TA dose is released after the first STP and the second TA dose is released after the second STP by biodegradation of the shell.

Abstract: A fluid infusion device including a housing that receives a sealed fluid reservoir is presented here. The fluid infusion device includes a drive motor assembly, an actuation mechanism, a force sensor, and at least one processor in the housing. The processor detects insertion of the fluid reservoir and incrementally rewinds the drive motor assembly to achieve an equilibrium state. The processor advances the drive motor assembly and obtains at least one measure of force using the force sensor until the at least one measure of force indicates that the fluid reservoir has reached an initial seated state. The processor performs a stabilizing cycle with the drive motor assembly. The processor advances the drive motor assembly and obtains at least one subsequent measure of force using the force sensor until the at least one subsequent measure of force indicates that the fluid reservoir has reached a subsequent sealed state.

Abstract: The invention discloses a detection and therapeutic device and remote monitoring shoes. The detection and therapeutic device comprises a power supply module (a) which is connected with modules with electricity needs and used for powering the modules, a main processor module (b) which is used for collecting and processing signals from sensors and controlling working status of an automatic injection module (d), a detection sensor module (c) which comprises a plurality of sensors in connection with the main processor module (b) and is used for examining nerves, organs or secretions and sending back the results to the main processor module (b), an automatic injection module (d) which comprises a plurality of automatic injectors in connection with the main processor module (b) and is used for administrating according to signals for controlling from the main processor module automatically.

Abstract: Methods, systems, and apparatuses integrating medical device data are disclosed. In an example embodiment, a vital sign monitor apparatus includes a renal failure therapy interface configured to receive a renal failure therapy parameter from a renal failure therapy machine performing a renal therapy treatment on a patient and an infusion pump interface configured to receive an infusion parameter from an infusion pump performing an infusion treatment for the same patient. The apparatus also includes a vital sign monitor engine configured to display, within a combination user interface of a vital sign monitor, the renal failure therapy parameter within a renal failure therapy timeline, and the infusion parameter within an infusion timeline that is aligned with the renal failure therapy timeline.

Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.

Abstract: Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.

Abstract: Apparatus for determining information associated with reflection characteristics of a surface comprising a sensor (60) configured to generate sensor output dependent on an intensity of light incident on the sensor and having a field of view directed at an external surface (57) in use; an illumination source (58) configured to emit light onto the external surface in use; an optically transparent window (61) located such as to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface in use; a light concentrator (66) fixed to or integral with the window, the light concentrator being configured to concentrate at least some light from the illumination source onto the external surface in use such that the concentrated light may be reflected from the external surface onto the sensor via the window; and a processor (40) configured to use the sensor output to determine information associated with reflection characteristics of the extern

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: A safety support device for a syringe comprises a support sheath for the body of the syringe and an inner sheath suitable for sliding relative to the support sheath between a waiting, retracted position and the extended position for protecting the needle of the syringe. The device has means for holding the syringe body relative to the support sheath and retaining means suitable for being activated to retain g the inner sheath in the waiting, retracted position inside the support sheath and for being deactivated by the piston of the syringe to allow the inner sheath to extend into its protective, extended position.

Abstract: The device allows the pain associated with the insertion of a needle of a syringe into the skin to be reduced. To do this, this device comprises a sleeve, which has a first rear portion to at least partially receive the syringe with the needle and a second front portion fitted with an end part, through which an opening passes for passage of the needle. A front face of the end part is intended to be applied with pressure against the skin of a person before insertion of the needle into the skin. This front face of the end part is arranged to receive an active substance for desensitizing the skin. The active substance can be applied to the skin at the instant the terminal part presses on the penetration site to desensitize the skin.

Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch.

Abstract: A system is disclosed. The system includes a reservoir for containing a fluidic medium, the reservoir including a front surface, a resilient cylindrical flexure portion connected to the front surface, the resilient cylindrical flexure portion comprising an accordion-like structure that is able to expand and contract to change an interior volume within the resilient cylindrical flexure portion, a central passageway within the resilient cylindrical flexure, and a collection chamber connected to the central passageway. Also, a system including a reservoir, a plunger head located within the reservoir, a plunger arm connected to the plunger head, a driving shaft connected to the plunger arm, and a motor connected to the driving shaft, the motor controllable to move the drive shaft in a first motion and a second motion so as to move the advance plunger head and retract the plunger head within the reservoir.

Abstract: Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices. Formulations and methods of manufacture are provided for dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations.

Abstract: An endotracheal tube apparatus and method includes a tube with a first end and a second end and an inside and an outside. Dual inflatable balloons are connected in spiral relation with the outside of the second end and a suction tube with more than one suction port is connected with the tube such that the more than one suction port captures secretions from the outside of the tube.

Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.

Abstract: The present disclosure relates to a leak detection system and method for tube or catheter placement. The system and method includes acoustically sensing a leak in the seal between a tube or catheter within a body and the body cavity against which it is sealed, assisting the user in adjusting the system until the leak has been substantially sealed, and establishing system parameters to be used thereafter to maintain the system in an operating state that will substantially prevent leakage, all using a noninvasive acoustic technique.

Abstract: A medical device system is provided. The medical device system includes a positioning apparatus having a body section and an upper section, the upper section slidably coupled to the body section such that the upper section slidably moves relative to the body section. The medical device also includes a flexible guide rod extending through the positioning apparatus and configured to be inserted into a passage of a respiratory system of a subject. The flexible guide rod includes a visible light emitter configured to emit visible light within the passage of the respiratory system and is visible outside the subject.

Abstract: A liner for use with a respiratory mask having a frame portion which is detachable from a cushion portion is provided, the liner including a body constructed from an absorbent material, the body having a first end and a second end, the body including a hose aperture adjacent the first end and sized for placement over a hose connector of the respiratory mask, and a mouth aperture adjacent the second end for placement over a mouth opening of the mask to allow air to flow into a user's mouth.

Abstract: A respiratory interface device is provided. The respiratory interface device includes at least one elongated support member structured to contact a user. The support member has at least one conduit portion and at least one porous portion. The conduit portion is structured to allow the passage of gas therethrough. The conduit portion is structured to be in fluid communication with a pressure generating system and with the porous portion. The porous portion is structured to allow for axial passage of gas therethrough and for radial exhaust of gas therefrom.

Abstract: An apparatus and method for resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted. A ventilator is used for delivering a gas mixture to the patient. The ventilator is configured to adjust the partial pressure of CO2 to one or more partial pressures high enough to slow expiration of CO2 from the patient's lungs and thereby maintain a reduced pH in the patient's tissues for a period of time following return of spontaneous circulation.

Abstract: An anesthetic tank includes an insertion mouth for inserting an injection adapter of an anesthetic container, and a storage portion communicating with the insertion mouth. A volatile anesthetic inside of the anesthetic container is injected into the storage portion. An identifying member is arranged on the outside of the insertion mouth and is rotatable around the center axis of the insertion mouth. The identifying member has key groove formed in the internal surface of an insertion hole for inserting the injection adapter. The key groove are used for identifying the type of the volatile anesthetic in collaboration with keys formed in the injection adapter. A cover member has an opening formed in the position facing the insertion mouth and the insertion hole and presses the peripheral part of the identifying member.

Abstract: In summary the invention relates to a stimuli control system configured for finding ambient stimuli from a database in a way so that the ambient stimuli having the most promising effect on stress reduction is selected. The selection may be performed based on a probability distribution created for describing how likely it is that a given ambient stimuli has a positive effect on the stress level for a given patient or other user. The database is a multiuser database which may be updated based on experiences from users' already registered ambient stimuli.

Abstract: An article that includes a guidewire and a removable angled guidewire storage device. The guidewire comprises an angled portion that is at an angle relative to a reminder of the guidewire. A distal end of the removable angled guidewire storage device has a conical shape having a wall that is configured to maintain the angled portion of the guidewire at the angle relative to the reminder of the guidewire. A proximal end of the removable angled guidewire storage device has an opening that is adapted to fit over at least a portion of an introducer. The angled guidewire storage device includes an internal channel having walls extending between the conical shape at the distal end of the removable angled guidewire storage device and the opening at the proximal end of the angled guidewire storage device for receiving and holding the guidewire.

Abstract: Catheters, sheaths, or other tubular devices are provided that include a proximal end, a distal end sized for introduction into a patient's body, and a steerable distal portion carrying a plurality of electrodes. The tubular device includes a primary lumen extending between the proximal and distal ends; a steering element lumen adjacent the primary lumen; a plurality of wires extending proximally from the electrodes, and reinforcement members including windings extending helically along at least the distal portion, at least some of the windings passing between the primary and steering element lumens and wires, and at least some of the windings surrounding the primary lumen and one or both of the steering element lumen and the wires. In one embodiment, a steering element is slidably disposed within the auxiliary lumen. Apparatus and methods for making such tubular devices are also provided.

Abstract: Described herein is a hose, wherein the hose has a length having a distal end and a proximal end, and an inner diameter and an outer diameter. The hose is comprised of a first layer; and a second layer, wherein the first layer and the second layer extend along at least a portion of the length and wherein a longitudinal compressive force applied to either the distal end or the proximal end of the hose causes the first layer to lock against the second layer.

Abstract: A deflectable catheter including an outer member having a proximal portion and a distal portion, an elongated column member extending distally from the outer member and an inner member positioned coaxial with the outer member and attached to the column member. The inner member extends distally of the outer member and has a distal tip portion. A reinforcement member is positioned over the column member to restrict axial movement of the column member such that when one of the inner member or outer member is moved with respect to the other, axial compression of the column member is restricted by the reinforcement member causing the distal tip portion of the inner member to deflect laterally.

Abstract: A deflectable catheter including an outer member having a proximal portion and a distal portion, an elongated column member extending distally from the outer member and an inner member positioned coaxial with the outer member and attached to the column member. The inner member extends distally of the outer member and has a distal tip portion. A reinforcement member is positioned over the column member to restrict axial movement of the column member such that when one of the inner member or outer member is moved with respect to the other, axial compression of the column member is restricted by the reinforcement member causing the distal tip portion of the inner member to deflect laterally.

Abstract: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.

Abstract: Disclosed are devices, systems, and methods for providing access to a patient. The patient access device comprises a proximal end, a distal end and a lumen therethrough. The patient access device further comprises a hollow shaft, an input port and a liquid supply port. At least a portion of the lumen passes through the shaft. The input port is coupled to the lumen, and the lumen and the input port are constructed and arranged to receive an elongate probe. The liquid supply port is in fluid communication with the lumen. The patient access is constructed and arranged to reduce gas from exiting the distal end while a portion of the elongate probe is positioned in the patient access device.

Abstract: Preformed guiding stylet for introducing a septal lead in contact with the septum or other intra-corporal device in contact with body tissue. This stylet includes a flexible wire to be introduced by its distal end in a central lumen of the lead, and a control handle. The wire is elastically deformable in bending and has sufficient rigidity in torsion to enable transmission by the handle rotation of a rotational movement over the entire length of the wire. Unstressed, the wire comprises successively in its distal part a first curvilinear portion a first straight portion a second curvilinear portion and optionally a second straight portion. The first and second curvilinear portions extend in respective planes making an angle between them defining a dihedral which axis comprises the first straight portion. The total length of the first curvilinear portion coincides with the anatomical curvature of the venous system.

Abstract: The present disclosure is directed to multi-segment intraluminal guide wires including an elongate distal portion comprising a first metallic material (e.g., nitinol), an elongate proximal portion comprising a second metallic material (e.g., stainless steel). The distal and proximal portions may be directly joined together end to end by a solid-state weld joint. A diameter of the weld region surrounding the weld joint on either side of the weld joint may be reduced (e.g., ground down) relative to the diameter of the distal and proximal portions of the guide wire on either side of the weld region. A stiffness adjusting sleeve may be disposed over the weld joint so that a transition profile of bending stiffness across the weld region is gradual, rather than abrupt across the distal portion of the guide wire to the proximal portion of the guide wire. A polymer jacket may cover the sleeve and distal portion.

Abstract: A medical device comprising a corewire, sensor core, and coupler is presented. A portion of the corewire is disposed within a first end of the coupler, and a portion of the sensor core is disposed within a second end. Alternatively, the device comprises a corewire and a sensor assembly comprising a sensor core having first and second ends and a bore in the first end. A portion of the corewire is disposed within the bore. A method of manufacture comprises providing a corewire, sensor core, and coupler. The method further comprises inserting a portion of the corewire into a first end of the coupler, and a portion of the sensor core into a second end. Alternatively, the method comprises providing a sensor core having first and second ends, and a corewire. The method further comprises forming a bore in the first end, and inserting the corewire into the bore.

Abstract: A medical instrument is that the first holding portion or the second holding portion is capable of moving so that a distance between a distal end of the first holding portion and a distal end of the second holding portion changes from a first dimension which is larger than a diameter of the wire to a second dimension which is smaller than the diameter of the wire and the space is formed by the first holding portion and the second holding portion such that the wire is capable of rotating about a line connecting a first contact point where the first protrusion portion contacts with the wire with a second contact point where the second protrusion portion contacts with the wire.

Abstract: Disclosed is a method of reinforcing medical balloons by providing equally spaced axial reinforcement yarns around a pressurized and hermetically sealed balloon. The axial reinforcement yarns and the balloon are subsequently wrapped with a circumferential reinforcement yarn and the axial and circumferential reinforcement yarns are bonded to the outer surface of the balloon by the use of an adhesive.

Abstract: An applicator for treating skin conditions includes at least one treatment composition component and a discontinuity identification component. The at least one treatment composition component is configured to selectively deposit a treatment composition at a deposit location on the portion of skin. The discontinuity identification component is operably coupled to an electromagnetic energy detector. The discontinuity identification component includes circuitry configured to monitor a level of the one or more parameters as the applicator traverses the portion of skin and to control the at least one treatment composition component to selectively deposit the treatment composition to the deposit location on the portion of skin based on one or more inputs indicative of a decrease in reflection of an electromagnetic energy interrogation stimulus from the portion of skin at the deposit location.

Abstract: A dual material Y-connector for use in connection with medical tubing systems and the like includes an inner core made of a first material such as a rigid plastic material and an over-layer made of a second material such as a pliable thermoplastic elastomer. The Y-connector comprises a primary arm, a secondary arm and a convergence arm all in fluid communication with one another and may include a tubing segment bonded to the Y-connector convergence arm. The first material can be a transparent copolyester and the second material can be a translucent thermoplastic elastomer. Threaded caps having a multi-indentation configuration can be tethered to one or more arms and be configured to seal one or more Y-connector ports.

Abstract: A catheter connector device is provided including a device housing having a first port and a second port. A fixed sleeve support portion and a flexible, cantilevered sleeve cover extend longitudinally within a housing interior, to carry a flexible tubular sleeve having a sleeve through bore extending from the first port to the second port, for removable insertion of a catheter. The sleeve cover has a first portion, a second portion extending from the first portion and a third portion narrower than the first portion extending from the second portion. A slidable catheter lock switch, or slide button, is positional between a catheter-unlocking position adjacent to the third portion of the sleeve cover and a catheter-locking position engaging the first portion of the sleeve cover and flexing the tubular sleeve cover to crimp the tubular sleeve and retain the catheter within.

Abstract: The invention describes a total isolation diverter valve comprising a valve body whereon a main inlet conduit for inletting a fluid, a first outlet conduit for outletting the fluid and at least one second outlet conduit for outletting the fluid are obtained. The first outlet conduit for outletting the fluid is provided with a first fluid adhesion inner surface and the second fluid outlet conduit is provided with a second fluid adhesion inner surface. Between the main fluid inlet conduit and the two fluid outlet conduits a connection channel is interposed. On the connection channel at least one device for perturbing at least one of the first fluid adhesion inner surface and the second fluid adhesion inner surface is provided. The perturbation device is configured so as to cause a deviation of the fluid flow from the first fluid outlet conduit to the second fluid outlet conduit or vice-versa by exploiting a physical effect called Coand{hacek over (a)} effect.

Abstract: In various embodiments, the invention disclosed herein provides systems, devices and methods for providing electrical stimulation to a patient. An electrical mechanical interconnection is provided to facilitate user friendly systems and devices. Exemplary therapeutic electrical stimulation devices include a shoe connected mechanically and electrically to a conductor that provides signals for electrical stimulation.

Abstract: A method of manufacturing a detection/stimulation lead for implantation into a venous, arterial, or lymphatic network is shown and described. The method includes providing a microcable comprising a sheath of insulating material covering an electrically conductive core. The method further includes surrounding a portion of the microcable with an electrically conductive metal ring. The method also includes crimping the ring such that the thickness of the sheath is penetrated by a portion of the metal ring and such that an electrical connection is formed between the metal ring and the electrically conductive core.

Abstract: Architectures for implantable stimulators having N electrodes are disclosed. The architectures contains X current sources, or DACs. In a single anode/multiple cathode design, one of the electrodes is designated as the anode, and up to X of the electrodes can be designated as cathodes and independently controlled by one of the X DACs, allowing complex patient therapy and current steering between electrodes. The design uses at least X decoupling capacitors: X capacitors in the X cathode paths, or one in the anode path and X?1 in the X cathode paths. In a multiple anode/multiple cathode design having X DACs, a total of X?1 decoupling capacitors are needed. Because the number of DACs X can typically be much less than the total number of electrodes (N), these architectures minimize the number of decoupling capacitors which saves space, and ensures no DC current injection even during current steering.

Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.

Abstract: Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.

Abstract: A lead anchor includes an anchor body having a band section, guide members and a support section. The guide members and the support section are spaced apart from each other and define a band channel. Further, the lead anchor includes a flexible band that is coupleable to the guide members with at least a portion of the flexible band positionable within the band channel. The flexible band and the support section define a first lead channel having a spaced-apart distance between the flexible band and the support section. The first lead channel includes an open side for allowing a lateral ingress or egress of a portion of a lead. The lead anchor further includes a fastener movable relative to the anchor body to reduce or increase the spaced-apart distance of the first lead channel to hold or release, respectively, the portion of the lead within the first lead channel.

Abstract: A tine portion of an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from a distal end of the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, for example, defined by a single radius, preferably tapers from a first width thereof, in proximity to a proximal end thereof, to a smaller, second width thereof, in proximity to the distal end thereof, wherein the tip has a width that is greater than the second width of the hook segment. Alternately, the tine portion may include a hook segment that is defined by two radii and a straight section extending therebetween.

Abstract: A thoracoscopic electroporation device for carrying out electroporation on tissue includes a suction head and a plurality of needle electrodes. The needle electrodes include a central needle providing a first electrode and a plurality of second needles which are spaced-apart around the periphery of the suction head. The electrodes are movable from a retracted configuration to a deployed configuration and in the deployed configuration the needles extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head includes a suitable flexible material for biasing the suction head into the expanded deployed configuration. The suction head has channels for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the peripheral needles.

Abstract: Described is system for mapping user behavior to brain regions of interest. Using a cognitive-behavior model, a behavioral task is selected that is suited for a desired brain state. Using a functional-anatomical model coupled to the cognitive-behavior model, a set of high-definition neurostimulations is selected to be applied to the user during performance of the selected behavioral task. The selected set of high-definition neurostimulations targets specific regions of the user's brain. Changes in the user's brain state are sensed during application of the set of high-definition neurostimulations and performance of the selected behavioral task using at least one brain monitoring technique. The coupled functional-anatomical and cognitive-behavior models are adapted until the desired brain state is reached.