Patents Issued in September 25, 2018
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Patent number: 10081572Abstract: A copolymer includes a main hydrocarbon chain and side groups including carboxylic groups and polyoxyalkylate groups. The copolymer further includes gem-bisphosphonate groups. A composition, such as n admixture for suspensions of mineral particles, includes the copolymer. The copolymer can be used for fluidifying suspensions of mineral particles and maintaining the fluidity of such suspensions. The copolymer can also be used for reducing the sensitivity of hydraulic compositions to clays and alkaline sulfates.Type: GrantFiled: April 13, 2012Date of Patent: September 25, 2018Assignee: CHRYSOInventors: Kamel Chougrani, Frederic Leising
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Patent number: 10081573Abstract: Cementitious mixtures, compositions for use in cementitious mixtures, and methods of producing cementitious mixtures wherein the compositions are suitable for modifying or improving certain properties of the cementitious mixtures. The compositions include a superabsorbent polymer (SAP) hydrogel having a macromolecular network structure, and at least one pozzolanic material that is chemically incorporated into the macromolecular network structure of the SAP hydrogel.Type: GrantFiled: April 25, 2016Date of Patent: September 25, 2018Assignee: Purdue Research FoundationInventor: Kendra Ann Erk
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Patent number: 10081574Abstract: Method of converting calcium bentonite to sodium bentonite that is suitable for use as drilling mud or a cement additive. After the addition of a calcium bentonite sample to a prepared soda ash solution at predetermined soda ash/bentonite weight ratios, the bentonite suspension is continuously heated and stirred for up to 24 h. The heating and stirring are crucial towards enhancing the sodium activation of the bentonite, as well as other rheological properties of the bentonite.Type: GrantFiled: May 5, 2017Date of Patent: September 25, 2018Assignee: King Fahd University of Petroleum and MineralsInventors: Musaab Ibrahim Magzoub, Mustafa Saleh Nasser, Ibnelwaleed Ali Hussein, Mohamed Ahmed Nasr Eldin Mahmoud, Abdullah Saad Sultan
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Patent number: 10081575Abstract: A sintered ceramic component can have a final composition including at least 50 wt. % MgO and at least one desired dopant, wherein each dopant of the at least one desired dopant has a desired dopant content of at least 0.1 wt. %. All impurities (not including the desired dopant(s)) are present at a combined impurity content of less than 0.7 wt. %. A remainder can include Al2O3. The selection of dopants can allow for better control over the visual appearance of the sintered ceramic component, reduces the presence of undesired impurities that may adversely affect another part of an apparatus, or both. The addition of the dopant(s) can help to improve the sintering characteristics and density as compared to a sintered ceramic component that includes the material with no dopant and a relatively low impurity content.Type: GrantFiled: March 22, 2017Date of Patent: September 25, 2018Assignees: SAINT-GOBAIN CERAMICS & PLASTICS, INC., SAINT-GOBAIN CENTRE DE RECHERCHE ET D'ETUDES EUROPÉENInventors: Guangyong Lin, Yeshwanth Narendar, Brian C. LaCourse, Wesley R. Robbins, Daniel René Urffer
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Patent number: 10081576Abstract: According to one embodiment, a structure includes a polycrystalline substance of yttrium oxyfluoride as a main component. The yttrium oxyfluoride has a rhombohedral crystal structure, and an average crystallite size of the polycrystalline substance is less than 100 nanometers. When taking a peak intensity of rhombohedron detected near diffraction angle 2?=13.8° by X-ray diffraction as r1, taking a peak intensity of rhombohedron detected near diffraction angle 2?=36.1° as r2, and taking a proportion ?1 as ?1(%)=r2/r1×100, the proportion ?1 is not less than 0% and less than 100%.Type: GrantFiled: September 27, 2017Date of Patent: September 25, 2018Assignee: Toto Ltd.Inventors: Hiroaki Ashizawa, Masakatsu Kiyohara
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Patent number: 10081577Abstract: A cBN sintered body has 40%-85% cBN by volume and 15% to 60% binder phase by volume. and inevitable impurities. The binder phase has an Al compound including Al and at least one element selected from N, O and B, and a Zr compound including Zr and at least one element selected from C, N, O and B. The Zr compound includes ZrO, or ZrO and ZrO2. In an X-ray diffraction, where a peak intensity of a (111) plane of the ZrO is I1, a peak intensity of a (101) plane of tetragonal ZrO2 is I2t and a peak intensity of a (111) plane of cubic ZrO2 is I2c, a ratio of the intensity of I1 to total intensities of I1, I2t and I2c is 0.6-1.0, and an average grain size of the Al compound is 80 nm-300 nm.Type: GrantFiled: December 24, 2015Date of Patent: September 25, 2018Assignee: TUNGALOY CORPORATIONInventors: Yusuke Hirano, Kentaro Shiro
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Patent number: 10081578Abstract: Disclosed is a hydrophobic coating material that includes a wax-based material and a polyethylene- or polypropylene-based polymer material. Also disclosed is a coated fertilizer composition that includes a fertilizer granule and the hydrophobic coating material coated on the fertilizer granule. Further disclosed is a method of manufacturing a coated fertilizer composition that includes the steps of providing a fertilizer granule and coating the fertilizer granule with the hydrophobic coating material.Type: GrantFiled: May 3, 2016Date of Patent: September 25, 2018Assignee: HONEYWELL INTERNATIONAL INC.Inventors: Michael Jablon, Maria Anatolyevna Azimova, Gerald Smith
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Patent number: 10081579Abstract: An explosive composition comprising a liquid energetic material and sensitizing voids, wherein the sensitizing voids are present in the liquid energetic material with a non-random distribution, wherein the liquid energetic material comprises (a) regions in which the sensitizing voids are sufficiently concentrated to render those regions detonable and (b) regions in which the sensitizing voids are not so concentrated and wherein the explosive composition does not contain ammonium nitrate prill.Type: GrantFiled: December 13, 2012Date of Patent: September 25, 2018Assignee: ORICA INTERNATIONAL PTE LTDInventors: John Cooper, Ian John Kirby, Richard Goodridge, Vladimir Sujansky, Simon James Ferguson
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Patent number: 10081580Abstract: The present invention relates to a process for preparing cyclohexane by isomerizing a hydrocarbon mixture (HM1) comprising methylcyclopentane (MCP) in the presence of a catalyst. The catalyst is preferably an acidic ionic liquid. The starting material used is a stream (S1) which originates from a steamcracking process. The hydrocarbon mixture (HM1) obtained from this stream (S1) in an apparatus for aromatics removal has a reduced aromatics content compared to stream (S1), and (HM1) may optionally also be (virtually) free of aromatics. Depending on the type and amount of the aromatics remaining in the hydrocarbon mixture (HM1), especially in the case that benzene is present, the isomerization may additionally be preceded by performance of a hydrogenation of (HM1). In addition, depending on the presence of other components of (HM1), further purification steps may optionally be performed prior to or after the isomerization or hydrogenation.Type: GrantFiled: October 15, 2013Date of Patent: September 25, 2018Assignee: BASF SEInventors: Steffen Tschirschwitz, Kathrin Wissel-Stoll, Jochen Bürkle, Albena Kostova, Markus Schmitt, Veronika Wloka, Stephan Deuerlein, Marco Bosch, Steffen Oehlenschläger, Michael Schreiber, Gauthier Luc Maurice Averlant, Joni Joni, Roman Prochazka, Martin Bock, Alois Kindler, Daniela Malkowsky, Katharina Spuhl, Stefan Bitterlich, Daniel Pfeiffer
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Patent number: 10081581Abstract: A process for recovering butadiene from a C4 fraction is disclosed. The process may include: contacting a mixed C4 stream comprising butane, butene, and butadiene, with a solvent comprising an organic solvent and water in a butadiene pre-absorber column to recover an overheads fraction comprising at least a portion of the butane, butene, and water, and a first bottoms fraction comprising the organic solvent, butadiene, and at least a portion of the butene; and feeding the first bottoms fraction to a butadiene extraction unit to recover a butene fraction, a crude butadiene fraction, and a solvent fraction.Type: GrantFiled: July 7, 2016Date of Patent: September 25, 2018Assignee: Lummus Technology Inc.Inventors: Kevin John Schwint, Robert John Brummer
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Patent number: 10081582Abstract: The preparation of chlorinated hydrocarbons by reacting a chlorinated alkane substrate, such as 1,1,1,3-tetrachloropropane, with a source of chlorine, such as chlorine (Cl2), in the presence of a polyvalent molybdenum compound, such as molybdenum pentachloride, is described. With the method of the present invention, the chlorinated alkane product has covalently bonded thereto at least one more chlorine group than the chlorinated alkane substrate, and the chlorinated alkane substrate and the chlorinated alkane product each have a carbon backbone structure that is in each case the same.Type: GrantFiled: October 20, 2015Date of Patent: September 25, 2018Assignee: Eagle US 2 LLCInventors: Scott A. Sherwood, Stephen Robert Lester
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Patent number: 10081583Abstract: The present invention relates to a stripping method capable of recovering, by an environmentally friendly method, a high-purity ester-based compound without concern over the oxidation of an ester-based compound from a mixture containing the ester-based compound. The stripping method has advantages of generating no wastewater, enabling equipment costs to be reduced by simplifying the process, removing concern over the oxidation of an ester-based compound during the process, and enabling the reuse of the components recovered in the process.Type: GrantFiled: December 7, 2015Date of Patent: September 25, 2018Assignee: HANWHA CHEMICAL CORPORATIONInventors: Ki Taeg Jung, Hyo Suk Kim, Young Jo Kim, Kyong Jun Yoon, Kee Do Han
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Patent number: 10081584Abstract: The invention provides a process for the separation of MEG from a glycol stream comprising MEG and 1,2-BDO, said process comprising the steps of: (a) providing the glycol stream and an azeotrope-forming agent to a distillation column, (b) subjecting the glycol stream and the azeotrope-forming agent to distillation at a distillation temperature and a distillation pressure; (c) obtaining a first overhead stream comprising an azeotrope of MEG and the azeotrope-forming agent and a first bottoms stream comprising 1,2-BDO; and (d) subjecting the first overhead stream to phase separation in the presence of water to obtain an MEG-rich aqueous stream and an azeotrope-forming agent rich stream, wherein the azeotrope-forming agent is an organic solvent that forms a homogeneous azeotrope with MEG and does not form an azeotrope with 1,2-BDO at the distillation temperature and pressure.Type: GrantFiled: December 16, 2015Date of Patent: September 25, 2018Assignee: SHELL OIL COMPANYInventors: Kai Jürgen Fischer, Waldo Eugene De Villiers, Pieter Huizenga, Carmelo Perez Golf
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Patent number: 10081585Abstract: There are provided a compound containing a phenolic hydroxyl group, which exhibits excellent heat resistance and excellent flame retardancy in terms of a cured product thereof, a phenolic resin including the same, a curable composition and a cured product thereof, a semiconductor sealing material, and a printed circuit board. The compound containing a phenolic hydroxyl group has a molecular structure represented by the following General Formula (I): wherein X is a structural site represented by the following Structural Formula (x1) or (x2); wherein, in Formula (x1) or (x2), k is an integer of 1 to 3, m is 1 or 2, Ar is a structural site represented by the following Structural Formula (Ar1), and in a case where when k or m is 2 or greater, a plurality of Ar's may be the same as or different from each other; wherein r is 1 or 2.Type: GrantFiled: February 21, 2014Date of Patent: September 25, 2018Assignee: DIC CorporationInventors: Yutaka Satou, Ayumi Takahashi
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Patent number: 10081586Abstract: The present invention relates to a novel process for the synthesis of 9,9-bis(methoxymethyl)fluorene. The syntheses from fluorene to 9,9-bis(hydroxymethyl)fluorene via a hydroxymethylation and further to 9,9-bis(methoxymethyl)fluorene via a etherification are known. 9,9-bis(methoxymethyl)fluorene is a compound that is used as an electron donor for Ziegler-Natta catalysts. The present invention is related to an improvement in the synthesis of 9,9-bis(methoxymethyl)fluorene leading to a decrease in the amount of solvent used and an easier work up while achieving high yield and purity.Type: GrantFiled: May 30, 2016Date of Patent: September 25, 2018Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventor: Jaiprakash Brijlal Sainani
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Patent number: 10081587Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.Type: GrantFiled: June 14, 2016Date of Patent: September 25, 2018Assignee: Genomatica, Inc.Inventors: Mark J. Burk, Priti Pharkya, Stephen J. Van Dien, Anthony P. Burgard, Christophe H. Schilling
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Patent number: 10081588Abstract: A reactive distillation method comprises introducing a feed stream to a reactive distillation column, wherein the feed stream comprises ethanol, contacting the feed stream with one or more catalysts in the reactive distillation column during a distillation, and removing butyl acetate during the distillation from the reactive distillation column as a bottoms stream. The feed stream reacts in the presence of the one or more catalysts to produce a reaction product comprising ethyl acetate, butanol, and water, wherein the butanol and the ethyl acetate react to produce a reaction product comprising the butyl acetate.Type: GrantFiled: December 3, 2014Date of Patent: September 25, 2018Assignee: ResCurve, LLCInventors: Sagar B. Gadewar, Brian Christopher Vicente, Peter K. Stoimenov
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Patent number: 10081589Abstract: A method for manufacturing an ?-bromoacetophenone compound includes brominating a specific phenyl compound by reacting the specific phenyl compound with bromine in a solvent including at least one organic acid ester compound so as to obtain the ?-bromoacetophenone compound that is a liquid at 5° C. to 30° C.Type: GrantFiled: October 13, 2016Date of Patent: September 25, 2018Assignee: FUJIFILM CorporationInventors: Katsuhiro Shimono, Katsuyuki Yofu
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Patent number: 10081590Abstract: A device and a process for producing undecylenic acid methyl ester using methyl ricinoleate as raw material are provided. The device comprises a feed pump, a raw material pre-heater, a microwave catalytic reactor, a microwave generator, a temperature controller and an infrared sensor, a condenser, a product tank and a discharge pump. The feed pump is connected with the raw material pre-heater, which is connected with the inlet of the microwave catalytic reactor. The outlet of the microwave catalytic reactor is connected with the condenser, which is connected to the product tank and the discharge pump. The microwave catalytic reactor is located in the microwave generator, which is connected with the temperature controller and the infrared sensor. The process is as follows: high-purity methyl ricinoleate, used as the raw material, is converted to methyl undecene and heptaldehyde by microwave-assisted pyrolysis process, followed by isolation and purification to produce methyl undecene.Type: GrantFiled: August 26, 2017Date of Patent: September 25, 2018Assignee: Zhejiang University of TechnologyInventors: Yong Nie, Ying Duan, Ruchao Gong, Shangzhi Yu, Meizhen Lu, Jianbing Ji
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Patent number: 10081591Abstract: [6,6]-Phenyl C71 butyric acid derivatives (C70-PCBR3) having a selectivity of greater than 95 wt % of the ?-isomer are provided by reacting fullerene C70 with a dialkyl sulfonium tetrafluoroborate having the formula:Type: GrantFiled: December 23, 2016Date of Patent: September 25, 2018Assignee: NANO-C, INC.Inventors: Edward A. Jackson, Henning Richter
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Patent number: 10081592Abstract: The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.Type: GrantFiled: March 25, 2013Date of Patent: September 25, 2018Assignee: The Board of Trustees of the University of IllinoisInventors: Paul J. Hergenrother, Robert W. Huigens, III, Karen C. Morrison, Robert W. Hicklin, II, Timothy A. Flood, Jr.
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Patent number: 10081593Abstract: Provided are compounds of the following: wherein R1 is a saturated or unsaturated cyclic hydrocarbon optionally substituted with an alkyl and/or an OXO-ester, and R2 is a C4 to C14 hydrocarbyl, preferably the residue of a C4 to C14 OXO-alcohol. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.Type: GrantFiled: October 2, 2017Date of Patent: September 25, 2018Assignee: ExxonMobil Chemical Patents Inc.Inventors: Jihad M. Dakka, Christine A. Costello, Edmund J. Mozeleski, Stephen Zushma, Diana S. Smirnova, Catherine A. Faler, Victor DeFlorio
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Patent number: 10081594Abstract: Systems and methods for the production of phenol and acetone from cumene oxidation products. One method includes reacting cumene and an oxidizing agent to produce a cumene oxidation product including cumene hydroperoxide and dimethyl benzyl alcohol, converting at least a portion of the dimethyl benzyl alcohol to cumene hydroperoxide by reacting the at least a portion of the dimethyl benzyl alcohol with hydrogen peroxide in both an organic phase and an aqueous to produce a converted cumene oxidation product, and cleaving the converted cumene oxidation product to produce an output product including one or more of phenol, acetone, and alpha-methylstyrene.Type: GrantFiled: August 7, 2015Date of Patent: September 25, 2018Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Mark Erik Nelson, Arkady Samuilovich Dykman, Andrey Vladimirovich Zinenkov, Victor Vladimiovich Pinson
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Patent number: 10081595Abstract: The present invention is directed towards novel methods of synthesis of molindone, synthesis of the intermediates of molindone, and high-purity compositions of molindone. In particular, the invention relates to the methods of synthesis of molindone through the Mannich reaction.Type: GrantFiled: October 3, 2017Date of Patent: September 25, 2018Assignee: Supernus Pharmaceuticals, Inc.Inventors: Martin Hanbauer, Zarghun Nazir, Peter Hildebrand, Attilia Figini, Likan Liang, Tiziano Fumagalli
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Patent number: 10081596Abstract: The present invention relates to novel bis-indolylmethanes, a process for their preparation and their use in the preparation of technical textiles and PPE's (Personal Protective Equipments), namely in the preparation of UV-protective and anti-infective textiles and garments.Type: GrantFiled: October 4, 2016Date of Patent: September 25, 2018Assignee: SANKO TEKSTIL ISLETMELERI SAN VE TIC. A.S.Inventors: Acelya Aker, Nuket Ocal, Hikmet Nil Ergindemir, Agamirze Hamitbeyli
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Patent number: 10081597Abstract: The present invention relates to a process for preparation of dexmethylphenidate hydrochloride from racemic methylphenidate. The process involves the treatment of racemic mixture of dl-threo-methylphenidate base in the presence of di-pivaloyl-D-tartaric acid (D-DPTA) in a solvent to isolate dipivaloyl tartrate salt of d-threo-methylphenidate. The dipivaloyl tartrate salt of d-threo-methylphenidate is treated with a base to obtain a d-threo-methylphenidate base, which is extracted using a suitable solvent. The d-threo-methylphenidate base is treated with hydrochloric acid-isopropyl alcohol solution to obtain slurry of d-threo-methylphenidate hydrochloride also known as dexmethylphenidate hydrochloride. The dexmethylphenidate hydrochloride slurry is filtered and washed with acetone. The invention also discloses a process for recovery of D-DPTA from the salt mother liquor and from the spent aqueous layer.Type: GrantFiled: November 3, 2014Date of Patent: September 25, 2018Assignee: Embio LimitedInventors: Ashutosh Digambar Gupte, Sunil Vaman Joshi, Amit Hari Pakhurde
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Patent number: 10081598Abstract: The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 24, 2015Date of Patent: September 25, 2018Assignees: Eisai R&D Management Co., Ltd., Sogo Pharmaceutical Co., Ltd.Inventors: Yuta Suzuki, Kenji Hyodo, Yohei Tanaka
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Patent number: 10081599Abstract: The present invention relates to a preparation method of 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-formamide capable of enabling 4-chlorine-N-methylpyridine-2-formamide to react with 4-amino-3-fluorophenol in the presence of an inorganic base. The present invention employs the inorganic base to replace potassium t-butoxide in the prior art, thus effectively solving the problem of a potential safety hazard of the potassium t-butoxide in industrial production. In addition, after the reaction is completed, the present invention employs a crystallization method for separation to obtain a reaction product; thus compared with the methods of extraction, concentration and column isolation and purification employed in the prior art, the present invention has a simpler operation and a lower cost, results in less environment pollution and a higher yield, and is very suitable for industrial production.Type: GrantFiled: November 9, 2015Date of Patent: September 25, 2018Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Guan Wang, Xufeng Yu, Guo Wei, Jian Chai, Zhiqing Yang
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Patent number: 10081600Abstract: The invention features 2-alkoxy-11-hydroxyaporphine derivatives that selectively bind D2high receptors. The compounds are useful for imaging D2high receptors and for the treatment of diseases, such as Parkinson's disease, sexual dysfunction, and depressive disorders.Type: GrantFiled: November 9, 2016Date of Patent: September 25, 2018Assignee: The McLean Hospital CorporationInventors: John L. Neumeyer, Yu-Gui Si, Anna Waclawa Sromek
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Patent number: 10081601Abstract: The invention provides compounds for modulating glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.Type: GrantFiled: September 21, 2017Date of Patent: September 25, 2018Assignee: Alectos Therapeutics Inc.Inventors: Ramesh Kaul, Ernest J. McEachern, Jianyu Sun, David J. Vocadlo, Yuanxi Zhou, Yongbao Zhu
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Patent number: 10081602Abstract: Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.Type: GrantFiled: May 24, 2017Date of Patent: September 25, 2018Assignee: Nektar TherapeuticsInventors: Franco J. Duarte, Neel K. Anand, Pankaj Sharma, Devendrapratap Singh
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Patent number: 10081603Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.Type: GrantFiled: February 1, 2017Date of Patent: September 25, 2018Assignee: Epizyme Inc.Inventors: Richard Chesworth, Lorna Helen Mitchell, Gideon Shapiro, Kerren Kalai Swinger
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Patent number: 10081604Abstract: An imidazoline compound, a mobility control system, a plugging agent for gas channelling, and a method for carbon dioxide flooding. The structure of the imidazoline compound is represented by formula (1), in which R is pentadecyl, heptadecenyl, or heptadecyl. A mobility control system that contains the imidazoline compound can interact with carbon dioxide to form a plugging agent for gas channelling, and thereby attains a plugging effect for carbon dioxide channelling in a carbon dioxide flooding process.Type: GrantFiled: September 26, 2017Date of Patent: September 25, 2018Assignee: China University of Geosciences (Beijing)Inventors: Qing You, Caili Dai, Yan Zhang, Yifei Liu, Jichao Fang, Huan Wang
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Patent number: 10081605Abstract: Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.Type: GrantFiled: March 11, 2016Date of Patent: September 25, 2018Assignee: Lumos Pharma, Inc.Inventors: William R. Cantrell, Jr., William E. Bauta
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Patent number: 10081606Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.Type: GrantFiled: September 15, 2017Date of Patent: September 25, 2018Assignee: Celgene CAR LLCInventors: Kwangho Lee, Deqiang Niu, Russell C. Petter, Juswinder Singh
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Patent number: 10081607Abstract: Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.Type: GrantFiled: October 31, 2014Date of Patent: September 25, 2018Assignee: University of South FloridaInventors: Roman Manetsch, Lindsey Neil Shaw, Kurt Steven Van Horn, Whittney Nicole Burda
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Patent number: 10081608Abstract: Disclosed are triazine derivative compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides.Type: GrantFiled: December 29, 2016Date of Patent: September 25, 2018Assignee: FMC CORPORATIONInventors: Atsushi Shibayama, Ryu Kajiki, Masami Kobayashi, Takashi Mitsunari, Atsushi Nagamatsu
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Patent number: 10081609Abstract: The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.Type: GrantFiled: March 14, 2014Date of Patent: September 25, 2018Assignees: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: Sangeeta Bhatia, Jing Shan, Michelle Palmer, Nathan Ross
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Patent number: 10081610Abstract: Methods of synthesizing 2-(1?H-indole-3?-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ITE or its structural analogs.Type: GrantFiled: September 10, 2015Date of Patent: September 25, 2018Assignee: ARIAGEN, INC.Inventors: Jiasheng Song, Suoming Zhang, Guodong Li, Luquing Yang
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Patent number: 10081611Abstract: An improved process for acid-catalyzed acylation using water-tolerant Lewis acid catalysts is described. The method involves reacting a reduction products of 5-(hydroxylmethyl)-furfural (HMF), in particular either furan-2,5-dimethanol (FDM) or bis-2,5-(hydroxymethyl)-tetrahydrofuran (bHMTHFs), with an excess of an organic acid in the presence of a Lewis acid metal triflate at a temperature and time sufficient to produce esters. The conversions of the reduction products of HMF to corresponding diesters can be quantitative with certain favored Lewis acids catalysts.Type: GrantFiled: November 21, 2014Date of Patent: September 25, 2018Inventor: Kenneth Stensrud
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Patent number: 10081612Abstract: Industrial scale conversions of 5-hydroxymethylfurfural to commodity chemicals such as 1,2,6-hexanetriol and 1,6-hexanediol by chemocatalytic conversions using hydrogen and a heterogeneous reduction catalyst are provided. The reactions are suitable for use in continuous flow reactors. Methods of carrying out the conversions are provided, as are product and catalyst compositions.Type: GrantFiled: January 26, 2017Date of Patent: September 25, 2018Assignee: ARCHER-DANIELS-MIDLAND COMPANYInventors: Valery Sokolovskii, Mayya Lavrenko, Alfred Hagemeyer, Eric L. Dias, James A. W. Shoemaker, Vincent J. Murphy
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Patent number: 10081613Abstract: Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2Type: GrantFiled: July 6, 2017Date of Patent: September 25, 2018Assignee: Givaudan, S.A.Inventors: Fridtjof Schröder, Urs Mueller, Jürg Daniel Oetiker
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Patent number: 10081614Abstract: The present invention relates to bis(sulfonamide) compounds and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as a medicament for the treatment and/or prevention of a disease, disorder or condition in which modulation of microsomal prostaglandin E synthase-1 activity is beneficial, such as pain, inflammation and cancer.Type: GrantFiled: November 24, 2015Date of Patent: September 25, 2018Assignee: ACTURUM REAL ESTATE ABInventors: Peter Söderman, Mats A. Svensson, Annika Kers, Liselott Öhberg, Katharina Högdin, Andreas Hettman, Jesper Hallberg, Maria Ek, Johan Bylund, Johan Nord
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Patent number: 10081615Abstract: The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain.Type: GrantFiled: December 12, 2014Date of Patent: September 25, 2018Assignee: Bio-Pharm Solutions Co., Ltd.Inventor: Yong Moon Choi
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Patent number: 10081616Abstract: The present invention features compounds having soluble epoxide hydrolase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.Type: GrantFiled: August 26, 2015Date of Patent: September 25, 2018Inventors: Ying Zhang, Anthony D. Keefe, Christoph Dumelin
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Patent number: 10081617Abstract: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.Type: GrantFiled: April 11, 2016Date of Patent: September 25, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Eric Mertz, Scott D. Edmondson, Sung-Sau So, Wanying Sun, Weiguo Liu, Santhosh F. Neelamkavil, Ying-Duo Gao, Alan Hruza, Yi Zang, Amjad Ali, Rudrajit Mal, Jiafang He, Rongze Kuang, Heping Wu, Anthony K. Ogawa, Andrew F. Nolting
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Patent number: 10081618Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.Type: GrantFiled: January 27, 2014Date of Patent: September 25, 2018Assignee: Janssen Sciences Ireland UCInventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie-Bernard Raboisson, Samuël Dominique Demin
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Patent number: 10081619Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.Type: GrantFiled: September 8, 2017Date of Patent: September 25, 2018Assignee: BIOGEN MA INC.Inventors: Brian T. Hopkins, Bin Ma, Timothy Raymond Chan, Lihong Sun, Lei Zhang, Gnanasambandam Kumaravel, Joseph P. Lyssikatos, Kevin Koch, Hua Miao
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Patent number: 10081620Abstract: There is provided a labeling precursor compound represented by the following general formula (2): wherein R1 represents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a monocyclic or condensed polycyclic aryl group or a nitrogen-containing heterocycle; R2 and R3 each independently represent an alkyl group or a hydroxyalkyl group which hydroxy group may be protected with a protecting group, and n is an integer of 1 or 2; R6 represents an alkyl group or —CONR11R12 wherein R11 and R12 each independently represent an alkyl group or a monocyclic or condensed polycyclic aryl group; and R4, R5, R7 and R8 each independently represent a hydrogen atom, an alkyl group or an alkoxy group.Type: GrantFiled: September 1, 2016Date of Patent: September 25, 2018Assignees: NIHON MEDI-PHYSICS CO., LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Masahito Toyama, Masato Kiriu, Hiroshi Tanaka
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Patent number: 10081621Abstract: The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.Type: GrantFiled: April 1, 2015Date of Patent: September 25, 2018Assignee: Vertex Pharmaceuticals IncorporatedInventors: Ali Keshavarz-Shokri, Beili Zhang, Tim Edward Alcacio, Elaine Chungmin Lee, Yuegang Zhang, Mariusz Krawiec