Abstract: The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.

Abstract: Provided herein are anti-angiogenic monoclonal antibodies and antigen-binding antibody fragments that selectively and specifically bind to an epitope in both fibronectin and either fibrinogen or fibrin fragment E, compositions containing these antibodies and antibody fragments, and methods of using these antibodies and antibody fragments.

Abstract: The invention provides monoclonal antibody 5C1 and related antibodies. The 5C1 antibody binds to an epitope within residues 118-126 of ?-synuclein. The antibodies of the invention are useful, for example, for treating and/or diagnosing disorders associated with ?-synuclein, particularly accumulation of ?-synuclein deposits. Such disorders include Lewy body diseases, such as Parkinson's disease, Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy (MSA).

Abstract: This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are disclosed which bind to M-CSF and which inhibit binding of M-CSF to the M-CSF receptor with an IC50 of 10 pM or less. The invention also relates to nucleic acids, vectors and host cells capable of expressing the antibodies or fragments thereof of the invention, pharmaceutical compositions comprising the antibodies or fragments thereof and uses of said antibodies or fragments thereof and compositions for treatment of specific diseases.

Abstract: Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.

Abstract: Interleukin-18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.

Abstract: This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to methods of preventing platelet ectodomain shedding, preventing platelet clearance and degradation, maintaining and increasing platelet blood serum levels for in vitro or in vivo applications. In some embodiments, the disclosure relates to the production, diagnostic use, and therapeutic use of monoclonal and polyclonal antibodies, and the antigen-binding fragments thereof, which specifically bind GPIba. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies for specific binding agent. Compositions and methods for inhibiting shedding, clearance, or degradation, or treating diseases associated with GPIba ectodomain shedding are also described.

Abstract: The present invention provides compositions comprising anti-CEACAM1 antibodies, compositions comprising antibodies capable of inhibiting or blocking the interaction between PD-1 and its ligands, and methods for their combined use in treating cancer.

Abstract: Anti-SIRP? antibodies, including multi-specific anti-SIRP? antibodies, are provided, as are related compositions and methods. The antibodies of the disclosure bind to SIRP? and can block the interaction of CD47 on one cell with SIRP? on a phagocytic cell. Antibodies that are bispecific for SIRP? and a second antigen are termed Bi-specific Macrophage Enhancing (BiME) antibodies and have emergent properties. The subject anti-SIRP? antibodies find use in various therapeutic methods. Embodiments of the disclosure include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the anti-SIRP? antibodies; and cell lines that produce the antibodies. Also provided are amino acid sequences of exemplary anti-SIRP? antibodies.

Abstract: Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-LAG-3 antibody in combination with an anti-PD-1 antibody.

Abstract: The invention provides antibodies which bind to LY75. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including pancreatic cancer, ovarian cancer, breast cancer, colorectal cancer, esophageal cancer, skin cancer, thyroid cancer, lung cancer, bladder cancer, multiple myeloma and lymphoma.

Abstract: The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for hemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP).

Abstract: Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.

Abstract: The present teachings show that it is possible to polymerize 1,1-disubstituted alkene compounds in an emulsion (for example using a water based carrier liquid), despite the possible reactions between the monomer and water. Polymerization of 1,1-disubstituted alkene compounds in an emulsion provides opportunities to better control the polymerization compared with bulk polymerization. The emulsion polymerization techniques can be employed for preparing homopolymers, copolymers (e.g., random copolymers), and block copolymers.

Abstract: A process for the preparation of a copolymer of propylene and ethylene comprising polymerizing propylene and ethylene in the gas phase in the presence of a solid particulate catalyst free from an external carrier comprising: (i) a symmetrical complex of formula (I), wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R?2C—, —R?2C—CR?2—, —R?2Si—, —R?2Si—SiR?2—, —R?2Ge—, wherein each R? is independently a hydrogen atom, C1-C20-alkyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl; R2 is a C1-C20 hydrocarbyl radical; m is 2 to 5; R9 is a H or C1-C20 hydrocarbyl radical; R7 is a hydrogen atom or a C1-10 hydrocarbyl radical; n is 0 to 3; R1 is a C1-C20 hydrocarbyl radical and optionally two adjacent R1 groups taken together can form a further mono or multicyclic ring condensed to Ph ring optionally substituted by one or two groups R4; and R4 is a C1-C10 alkyl radical; and (ii) a cocatalyst, preferably comprising an organometallic compound of

Abstract: The present disclosure relates to a process for chlorination of a polymer. The process of the present disclosure includes minimum use of light and maximum chlorine utilization for getting maximum chlorination yield. The chlorinated polymer obtained by the process of the present disclosure exhibit improved properties viz. thermal stability, color, inherent viscosity and mechanical properties.

Abstract: A method for preparing a functionalized polymer, the method comprising the steps of polymerizing monomer to form a reactive polymer, and reacting the reactive polymer with a polycyano compound.

Abstract: The invention relates to a method for preparing a dry cationic hydrogel polymer product. The method comprises polymerization of a reaction mixture comprising ethylenically unsaturated monomers in presence of water and initiator(s) by radical polymerization and obtaining a hydrogel polymer. The hydrogel polymer is comminuted by chopping or shredding, and dried, whereby a dry hydrogel polymer product in powder form is obtained. At least one cationic reverse phase emulsion polymer is added to the hydro polymer at the comminuting step. The invention relates also to a dry cationic hydrogel polymer composition prepared by the method and its use.

Abstract: Provided are a powdery diacetal clarifying agent and a method of preparing the same. The powdery diacetal clarifying agent comprises a diacetal compound and an inorganic silicon-containing compound having a pH value equal to or more than 6 and equal to or less than 12. The powdery diacetal clarifying agent of the composition can have excellent flowability, dispersability, thermal resistance, and color stability. Accordingly, the powdery diacetal clarifying agent does not release stinking odor and incur yellowing at high temperature, allowing the plastic articles to have improved appearance and visual appeal.

Abstract: The present invention relates to crosslinkable compositions comprising vinylidene fluoride (VDF)/trifluoroethylene (TrFE) polymers and a fluorine-containing crosslinking agent of formula (A) [agent (Cz)]: {N3[S(O)g1]s1}na—(RH)nh—Rf—(R?H)nh?—{[S(O)g2]s2N3}na?, formula (A) wherein each of g1 and g2, equal to or different from each other, is 1 or 2, each of s1 and s2, equal to or different from each other, is 0 or 1, each of na and na? is independently zero or an integer of 1 to 3, provided that the sum na+na? is at least 2, each of RH and R?H, equal to or different from each other, is a C1-C12 hydrocarbon group free of fluorine atoms, nh and nh?, equal or different from each other are independently 0 or 1, and Rf is selected from the group consisting of i) a C3-C20 fluorocarbon group, possibly comprising one or more ethereal oxygen atoms, ii) an oligomer comprising copolymerized units of vinylidene fluoride and trifluoroethylene, to a process for the manufacture of said compositions, to a method for curing the

Abstract: A retardation material-forming resin composition for providing an orientation material that has high photoreaction efficiency and with which a polymerizable liquid crystal can be aligned in a highly sensitive manner. A retardation material-forming resin composition being thermally curable wherein including a resin (component (A)) having a photo-aligning group to which a thermally reactive moiety is bonded directly or connected via a linking group; an orientation material obtained by use of the composition, and a retardation material formed by use of a cured film obtained from the composition.

Abstract: The present invention is directed to a copolymer of a first monomer and a second monomer, wherein the first monomer is selected from the group consisting of 1,3-butadiene, isoprene, and styrene; and the second monomer is of formula I or V wherein R1 is a covalent bond, phenylene, a linear or branched alkane diyl group containing 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; R2 and R3 are independently linear or branched alkyl groups containing 1 to 10 carbon atoms; R4 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; and R5 is a linear or branched alkane diyl group containing 1 to 20 carbon atoms, or a bridging aromatic group. The invention is further directed to a rubber composition including the copolymer, and a pneumatic tire containing the rubber composition. The invention is further directed to a method of making such a copolymer.

Abstract: A cross-linked rubber obtained by cross-linking a nitrile rubber composition, wherein the nitrile rubber composition contains a carboxyl group-containing nitrile rubber (a) with an iodine value of 120 or less and a diurethane compound (b) represented by a following general formula (1), a content of the diurethane compound (b) in the nitrile rubber composition is 5 to 15 parts by weight with respect to 100 parts by weight of the carboxyl group-containing nitrile rubber (a), and a tensile strength of the cross-linked rubber based on JIS K6251 is 15 MPa or more and an elongation at break of the cross-linked rubber based on JIS K6251 is 300% or more, is provided.

Abstract: This disclosure is directed to a self-crosslinkable polymer and and an aqueous dispersion comprising particles of the polymer. The self-crosslinkable polymer has a molecular skeleton containing urethane linkages, and a hydrazide functional group and a carbonyl functional group capable of reacting with the hydrazide functional group chemically bonded to the molecular skeleton.

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: The present application provides the block copolymers and their application. The block copolymer has an excellent self assembling property and phase separation and various required functions can be freely applied thereto as necessary.

Abstract: A rubber composition contains a diene rubber component containing at least 20 mass % of a modified conjugated diene rubber, a silica, and a silane coupling agent; the modified conjugated diene rubber having at least one modified part and at least one conjugated diene rubber part; the conjugated diene rubber part having a conjugated diene copolymer block and an isoprene block containing from 70 mass % to 100 mass % of isoprene units in each conjugated diene rubber part; the modified part bonding to an end of the conjugated diene rubber part and having a functional group which interacts with the silica; a content of the silica being from 60 to 200 parts by mass per 100 parts by mass of the diene rubber component; the silane coupling agent being a polysiloxane represented by formula (1), (A)a(B)b(C)c(D)d(R1)eSiO(4-2a-b-c-d-e)/2, and having a content from 1.0 to 20 mass % of the content of the silica.

Abstract: Additives for making polyurethanes are disclosed. The additives are based on combining specific carboxylic acids or carboxylic di-acids together with a gelling catalysts obtained when mixing an isocyanate-reactive tertiary amine catalysts with dimethyl tin di carboxylate salts and/or dimethyltin mercaptide salts.

Abstract: An aspect of the present invention relates to a composition, which is a composition for a magnetic recording medium and comprises an isocyanate compound in the form of an adduct of a polyhydroxyl compound having one or more aromatic carbon rings and three or more hydroxyl groups per molecule with a polyisocyanate having two or more isocyanate groups per molecule.

Abstract: Disclosed are compositions that comprise water and a polyether polyol derived from sucrose and an alkylene oxide, as well as polyurethane foam systems comprising such compositions, methods for their production, and the resulting polyurethane foams.

Abstract: Disclosed is a polymerizable composition for an optical material containing polyisocyanate (a) including aliphatic polyisocyanate (a1) and a modified aliphatic polyisocyanate (a2); and polythiol (b) having a di- or higher functional thiol group, in which the modified aliphatic polyisocyanate (a2) is contained in the polyisocyanate (a) in the amount of less than or equal to 60 weight %.

Abstract: The disclosure relates to at least one partially reacted product of an isocyanate and an amine (e.g., a reaction product comprising at least one adducted compound). The reaction product comprises polyurea oligomers. The reaction product can be combined with at least one amine in order to formulate a curing agent for epoxy resins wherein the cured epoxy resin has enhanced fracture toughness. The at least partially reacted product does not increase the viscosity of the curing agent and is at least partially soluble in the amine component of the curing agent.

Abstract: The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.

Abstract: A process of forming a side-chain-functionalized polyhydroxyalkanoate (PHA) material is disclosed. The process includes forming a PHA material having a vinyl-terminated side-chain from a vinyl-terminated fatty acid via a bacterial fermentation process. The process also includes forming a PHA material having a hydroxyl-terminated side-chain from the PHA material having the vinyl-terminated side-chain. The process further includes chemically reacting the PHA material having the hydroxyl-terminated side-chain with 1,4-phenylenedimethanethiol or a chlorocoumarin or 2-furoyl chloride to form a side-chain-functionalized PHA material having a side-chain with a terminal cross-linkable group (e.g., thiol, coumarin, or furoyl group).

Abstract: The object of the present invention is to provide a polycarbonate resin which is excellent in various properties, such as heat resistance, optical properties, melt processability, etc., and an optical film composed of the same and the present invention relates to a polycarbonate resin containing at least a structural unit represented by the following formula (1) and a structural unit represented by the following formula (2): wherein in the formula (1), R1 to R6 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, an alkoxy group having 1 to 12 carbon atoms, or a halogen atom.

Abstract: The present invention relates to a polycarbonate copolymer and a preparation method therefor and, more specifically, to a polycarbonate copolymer comprising a fluorene ester oligomer and a polycarbonate as polymerization units, and a preparation method therefor.

Abstract: A branched polyarylene sulfide resin includes an —S— substituent group with a cleaved disulfide compound, which has a halogen content of 4,000 ppm or less, a melt viscosity as measured at a temperature of 330° C. and a shear rate of 2 sec?1 of 1.0×104 to 50.0×104 Pa·s, and a melt viscoelasticity tan ? as measured at a temperature of 310° C. and an angular velocity of 1 rad/sec of 0.1 to 0.6.

Abstract: The invention relates to a method to reduce or prevent agglomeration of rubber particles in aqueous media by LCST compounds and elastomers obtained thereby. The invention further relates to elastomer products comprising the same or derived therefrom.

Abstract: Provided is a process for preparing an improved compounded product and a compounded product prepared by the described process.

Abstract: Described herein is a composite comprising a matrix comprising a polymeric material; and at least one sized fiber selected from the group consisting of polyetherimide-sized fibers, epoxy-sized fibers, and combinations thereof.

Abstract: To provide a biaxially oriented polyamide-based resin film being excellent in laminate strength, pin-hole resistance under a low-temperature environment, impact resistance, and transparency, and which retains satisfactory a good external appearance even after being sterilized in hot water. A biaxially oriented polyamide-based resin film comprising a polyamide resin and 1 to 5% by mass of a polyamide-based block copolymer, wherein the polyamide-based block copolymer comprises a hard part including a residue of cyclic lactam having 4 to 10 carbon atoms, and a soft part including a residue of polyoxypropylene glycol or polyoxytetramethylene glycol having a weight average molecular weight of 500 to 3000, and the content X of the hard part and the content Y and the weight average molecular weight Mw of the soft part satisfy the following formulae (1) and (2): X+Y=100(parts by mass)??(1) 478.74×Mw?0.2989?Y?93(parts by mass)??(2).

Abstract: A microvascular system comprising a polymeric matrix and a planar structure, where the planar structure comprises a plurality of branched microfluidic channels in the matrix. At least a portion of the microfluidic channels are interconnected, and the interconnections between the channels are located in a plane defined by a longitudinal section of the planar structure.

Abstract: A thermoplastic elastomer foam is made by incorporating a gaseous or supercritical blowing agent under pressure into a molten thermoplastic elastomer comprising polymeric polymeric crystalline domains, then releasing the pressure to foam the thermoplastic elastomer.

Abstract: (A) a polymer composition (especially a polyester composition) which includes a compound of tungsten and oxygen (especially tungsten oxide particles) and an additional additive, wherein said additional additive is selected from an acetaldehyde scavenger and a colourant, wherein when said polymer composition includes an acetaldehyde scavenger, said polymer composition includes at least 10 ppm (suitably at least 25 ppm, preferably at least 50 ppm) of said acetaldehyde scavenger and when said polymer composition includes a colourant, said polymer composition includes at least SOpprh (suitably at least 75 ppm, preferably at least 100 ppm) of said colourant, wherein: preferably said article is a preform for a container; or (B) a sheet comprising a polymer composition (especially a polyester, polycarbonate or polyolefin composition) which includes a compound of tungsten and oxygen (especially tungsten oxide particles), wherein said sheet has a width of at least G.3 m.

Abstract: A resin particle composition includes resin particles, polishing agent particles having an average circle-equivalent diameter of 0.1 ?m to 3.0 ?m, and silica particles having a compression aggregation degree of 60% to 95% and a particle compression ratio of 0.20 to 0.40.

Abstract: A thermoplastic resin composition for automobiles, and a molded product produced from the composition, includes a semi-aromatic polyamide resin; a first chelate agent that includes an amino radical and at least one of a carboxylic acid and salt thereof; a second chelate agent that includes an aliphatic multivalent C1 to C10 carboxylic acid (not including a carbon atom of a carboxylic radical) having 2 to 4 carboxylic radicals; and a filler.

Abstract: The present invention discloses a modified polypropylene composition with higher flow activation energy and reduced necking in extrusion film/coat, wherein the composition comprises long chain branched polypropylene; a free radical initiator; a primary antioxidant; a secondary antioxidant; an acid neutralizer; and optionally a multifunctional monomer. Further the said composition of polypropylene shows higher sensitivity of viscosity to temperature, with improved stretchability.

Abstract: An aqueous silane coupling agent composition is obtained from cohydrolytic reaction of (i) a succinic anhydride-containing silane coupling agent and (ii) a mercapto-containing silane coupling agent in a molar ratio of 99:1 to 1:1. The composition has improved storage stability under high-temperature conditions and is effective as modifier.

Abstract: A method and apparatus for forming a composite structure. The apparatus comprises a fiber layer. The fiber layer comprises a plurality of fiber bundles and a number of filler portions. The plurality of fiber bundles has a number of spaces between the plurality of fiber bundles. A number of filler is comprised of discontinuous filaments that substantially fill the number of spaces between the plurality of fiber bundles.

Abstract: A tire tread comprises a composition based on at least an elastomer matrix comprising a polyisoprene and an unsaturated thermoplastic styrene elastomer which represents at most 50% by weight of the elastomer matrix, a reinforcing filler and a crosslinking system. The unsaturated thermoplastic styrene elastomer comprises at least one rigid styrene segment and at least one flexible isoprene segment, which at least one flexible isoprene segment has a glass transition temperature of less than ?20° C. Such a tread exhibits an improved resistance to crack propagation.