Patents Issued in September 27, 2018
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Publication number: 20180273854Abstract: The present disclosure provides a method for removing sulfur compounds from a fuel containing sulfur compounds. The method includes contacting the fuel with an adsorbent that comprises a carbonaceous material doped with nanoparticles of aluminum oxide to reduce the concentrations of the sulfur compounds. The carbonaceous material is at least one selected from the group consisting of activated carbon, carbon nanotubes, and graphene oxide, and the adsorbent has a weight ratio of C to Al in the range from 3:1 to 30:1, and a weight ratio of C to O in the range from 1:1 to 10:1.Type: ApplicationFiled: May 29, 2018Publication date: September 27, 2018Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALSInventors: Mazen Mohammad KHALED, Mazen Khaled NAZAL, Muataz Ali ATIEH
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Publication number: 20180273855Abstract: A process is presented for the removal of contaminants like sulfur compounds from hydrocarbons. The sulfur compounds are removed from hydrocarbons that may be a feed to cracking units. A feed stream is treated with a clinoptilolite or a barium exchanged zeolite adsorbent to effectively remove carbon disulfides from the feed hydrocarbon. The adsorbent may be regenerated by a hydrogen stream, a hydrocarbon stream or a mixture thereof.Type: ApplicationFiled: May 25, 2018Publication date: September 27, 2018
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Publication number: 20180273856Abstract: The present invention relates to a process for the treatment of refinery purge streams, containing a hydrocarbon component in slurry phase having a boiling point higher than or equal to 140° C., characterized by the presence of quantities of asphaltenes higher than or equal to 5% by weight and characterized by the presence of a solid content higher than or equal to 5% by weight. The process provides that said purge be mixed with a suitable fluxing agent according to appropriate ratios and under certain conditions, forming a suspension with a content higher than or equal to 10% by weight of compounds having a boiling point TbP lower than or equal to 350° C. After mixing, the suspension is sent to a liquid/solid separation step which operates under suitable conditions, separating a solid phase containing a residual organic component and a solid component, called cake, and a liquid phase containing residual solids. The solid phase obtained is cooled to below 60° C.Type: ApplicationFiled: December 21, 2016Publication date: September 27, 2018Applicant: ENI S.p.A.Inventor: Andrea BARTOLINI
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Publication number: 20180273857Abstract: The present invention relates to a process for producing monoaromatic hydrocarbons from a hydrocarbon feed comprising polyaromatics, the process comprising contacting said feed in the presence of hydrogen with a M/zeolite catalyst under hydrocracking process conditions.Type: ApplicationFiled: September 15, 2016Publication date: September 27, 2018Inventors: Luis Aramburo, Emiel van Kimmenade, Dustin Farmer, Scott A. Stevenson
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Publication number: 20180273858Abstract: The invention relates to various nonlimiting embodiments that include methods, apparatuses or systems for processing natural gas comprising a heavies removal column processing natural gas and light oil reflux. The overhead stream goes to heavies treated natural gas storage. The heavies removal column reboiler bottoms stream product is input to a debutanizer column. The debutanizer column overhead lights are input to a flash drum where the bottoms is pumped through a heat exchanger as a light oil reflux input to the heavies removal column, while the debutanizer reboiler bottoms product is stored as stabilized condensate. Alternatively, debutanizer column overhead lights are sent to heavies treated gas storage and the bottoms stream product goes to a depentanizer column, the overhead lights are pumped through a heat exchanger as a light oil reflux input to the heavies removal column, while the depentanizer reboiler bottoms product is stabilized condensate.Type: ApplicationFiled: March 20, 2018Publication date: September 27, 2018Inventors: Paul R. DAVIES, Michael J. CALDERON, Dale L. EMBRY, David W. LARKIN, Qi MA
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Publication number: 20180273859Abstract: A process and apparatus for making aromatics are described. The process includes reforming a naphtha stream in a reforming zone to form a reformer effluent comprising aromatic compounds and non-aromatic compounds, wherein at least a portion of the aromatic compounds contain alkyl groups. The reformer effluent is heated and passed directly to an acid cracking reaction zone. The non-aromatic compounds are selectively cracked and at least a portion of the alkyl groups on the aromatic compounds are selectively dealkylated in the presence of an acid cracking catalyst to form a cracked reformer effluent comprising the aromatic compounds and cracked olefins.Type: ApplicationFiled: June 1, 2018Publication date: September 27, 2018Inventors: Stanley J. Frey, Hayim Abrevaya, Gregory R. Werba
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Publication number: 20180273860Abstract: A refinery built around a slurry phase hydrocracking process unit, such as a Veba Combi-Cracker (VCC), is simpler, produces more liquid product as transportation fuels and has much higher net cash margin than a refinery built around a coker or other bottoms upgrading processes. The VCC unit replaces one or more processing steps normally included in refineries as separate and distinct processing units including heavy distillate/gas oil cracking and optionally bottoms upgrading and deep desulfurization of diesel and gasoline range cuts. The refinery design is especially suited for heavy crude upgrading and can be tuned to provide a wide range of gasoline to distillate production ratios. The refinery design is “bottomless” in the sense that it produces no heavy fuel oil or asphalt as product and no solid fuel (e.g., petroleum coke).Type: ApplicationFiled: November 4, 2015Publication date: September 27, 2018Inventors: Andreas Schleiffer, Paul M. Ziegelaar
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Publication number: 20180273861Abstract: The use of a copolymer as a detergent additive in an internal combustion engine liquid fuel. The copolymer obtained by copolymerization of at least: an alkyl acrylate or alkyl methacrylate monomer ma and a styrenic monomer mb chosen from styrenics derivatives, the aromatic ring of which is substituted by at least one group R or at least one linear or branched C1 to C12 hydrocarbon-based chain substituted by at least one group R being chosen from: the hydroxyl group, a group —OR?, a group —(OCyH2yO)f—H, a group —(OCyH2yO)f—R?, a group —O—(CO)—R?, and a group —(CO)—OR?, where y is an integer ranging from 2 to 8, f is an integer ranging from 1 to 10, and R? is chosen from C1 to C24 alkyl chains. Also, a process for maintaining the cleanliness of and/or for cleaning at least one of the internal parts of an internal combustion engine.Type: ApplicationFiled: September 15, 2016Publication date: September 27, 2018Applicant: TOTAL MARKETING SERVICESInventor: Julie PREVOST
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Publication number: 20180273862Abstract: Disclosed herein is a method for synthesizing a nano-emulsion fuel composition. The method may include forming a water-in-fossil fuel emulsion by dispersing water into a fossil fuel in the presence of a surfactant, synthesizing carbon quantum dots with an average diameter between 0.5 nanometers to 20 nanometers, forming a mixture of the synthesized carbon quantum dots and the water-in-fossil fuel emulsion by dispersing the synthesized carbon quantum dots into the water-in-fossil fuel emulsion; the carbon quantum dots comprising 1 ppm to 10000 ppm of the mixture, and forming a nano-emulsion fuel composition by mixing a biofuel into the mixture of carbon quantum dots and the water-in-fossil fuel emulsion.Type: ApplicationFiled: May 30, 2018Publication date: September 27, 2018Applicants: Tarbiat Modares UniversityInventors: Ehsanollah Ettefaghi, Alimorad Rashidi, Barat Ghobadian, Gholamhasan Najafi, Mohammad Hadi Khoshtaghaza, Sepideh Pourhashem, Aliasghar Khalili, Zeinab Hajjar
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Publication number: 20180273863Abstract: An emulsion comprising water and an immiscible predominantly hydrocarbon-based liquid, wherein the emulsion further comprises at least one protein for inhibiting the growth of microorganisms, said protein containing or being capable of binding to one of: a monosaccharide and an oligosaccharide. Uses of the invention include, but are not limited to: applications in oil well/fracking operations where it is necessary or desirable to neutralise bacteria in the extracted liquid; as an additive emulsion for bio-diesel to reduce emissions, such as NOx etc.; and as an additive in the water of heating/cooling systems for its biocidal properties.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Inventor: Paul Hope
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Publication number: 20180273864Abstract: A process for producing methane from a biomass, biomass-containing and/or biomass-derived feedstock is provided. The process comprises: a) providing in a hydropyrolysis reactor vessel a hydropyrolysis catalyst composition, said composition comprising one or more active metals supported on an oxide-based support, said one or more active metals comprising at least one of cobalt and nickel and said one or more active metals being present in total in an amount in the range of from 2 to 75 wt % based on the overall weight of the catalyst composition; b) contacting the feedstock with said hydropyrolysis catalyst composition and molecular hydrogen in said hydropyrolysis reactor vessel, to produce a first product stream comprising char, catalyst fines and gases comprising hydrogen and hydrocarbons, of which hydrocarbons at least 70 wt % is methane and, optionally, CO and CO2; and c) removing said char and catalyst fines from said first product stream.Type: ApplicationFiled: September 23, 2016Publication date: September 27, 2018Applicant: Shell Oil CompanyInventors: Vikrant Nanasaheb URADE, Laxmi Narasimhan CHILKOOR SOUNDARARAJAN, Madhusudhan Rao PANCHAGNULA, Dhairya Dilip MEHTA
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Publication number: 20180273865Abstract: A method of producing atomic or quantum fuel includes the steps of providing a plurality of spinning bodies having mass, angularly accelerating the spinning bodies so as to spin each spinning body at angular velocities approaching the speed of light to thereby store energy in the spinning bodies, and in one embodiment so as to cause time dilation, triggering a conversion of the stored energy from an angular momentum of at least parts of the spinning bodies so as to convert the stored energy to translational or radiation energy.Type: ApplicationFiled: March 26, 2018Publication date: September 27, 2018Inventor: James Andrew Leskosek
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Publication number: 20180273866Abstract: A method for removing nitrogen from natural gas includes contacting substantially dry natural gas that contains unwanted nitrogen with lithium metal. The nitrogen reacts with lithium to form lithium nitride, which is recovered for further processing, and pipeline quality natural gas. The natural gas may optionally contain other chemical species that may be reduced by lithium, such as carbon dioxide, hydrogen sulfide, and small amounts of water. These lithium reducible species may be removed from the natural gas concurrently with the removal of nitrogen. The lithium nitride is subjected to an electrochemical process to regenerate lithium metal. In an alternative embodiment, lithium nitride is reacted with sulfur to form lithium sulfide and nitrogen. The lithium sulfide is subjected to an electrochemical process to regenerate lithium metal and sulfur. The electrochemical processes are advantageously performed in an electrolytic cell containing a lithium ion selective membrane separator.Type: ApplicationFiled: May 30, 2018Publication date: September 27, 2018Inventors: Ashok V. JOSHI, Sai BHAVARAJU
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Publication number: 20180273867Abstract: A process for torrefaction of biomass is provided in which biomass are passed into a fluidized bed or a non-fluidized bed reactor and heated to a predetermined temperature in an oxidizing environment. The dried biomass is then fed to a cooler where the temperature of the product is reduced to approximately 100 degrees Fahrenheit.Type: ApplicationFiled: June 4, 2018Publication date: September 27, 2018Inventors: Vijay Sethi, Clinton B. Camper, Jerrod D. Isaak
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Publication number: 20180273868Abstract: The present invention relates to a process for cooling hot torrefied biomass, which process comprises the steps of a) applying water onto the hot torrefied biomass, resulting in steam with entrained dust and organic volatiles, and cooled torrefied biomass comprising water; b) condensing the steam with entrained dust and organic volatiles to form a condensate comprising dust and organic volatiles; and c) recycling the condensate comprising dust and organic volatiles to step a). The invention also relates to a cooling device for cooling hot torrefied biomass enabling the cooling process according to the invention, and a system for producing torrefied biomass comprising such a cooling device.Type: ApplicationFiled: February 11, 2016Publication date: September 27, 2018Inventors: Peter Christiaan Albert BERGMAN, Maarten Kees HERREBRUGH, Timo KLEINGELD
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Publication number: 20180273869Abstract: To provide a steel wire rod having a lubricating coating, which can achieve both corrosion resistance such as long-term rust prevention property, and excellent appearance after heading. The steel wire rod of the present disclosure includes a lubricating coating on a surface thereof, wherein the lubricating coating includes silicon (A), tungsten (B) and an alkali metal salt of fatty acid (C), a dry mass ratio of (B)/(A) is in a range of 1.3 to 18 and a dry mass ratio of (C)/{(A)+(B)} is in a range of 0.14 to 2.0, and the lubricating coating contains no phosphorus.Type: ApplicationFiled: September 27, 2016Publication date: September 27, 2018Applicants: Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.), NIHON PARKERIZING CO., LTD.Inventors: Hirotaka ITO, Shigehiro YAMANE, Pham Van DUC, Tsuyoshi HATAKEYAMA, Shinobu KOMIYAMA
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Publication number: 20180273870Abstract: A method for improving fuel efficiency and energy efficiency, while maintaining or improving deposit control and cleanliness performance, in an engine lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil includes a base oil mixture. The base oil mixture includes a lubricating oil base stock as a major component, and at least one cobase stock, as a minor component. The at least one cobase stock is present in an amount sufficient to reduce kinematic viscosity (Kv100) of the base oil mixture as determined by ASTM D445, while maintaining or controlling cold cranking simulator viscosity (CCSV) of the lubricating oil as determined by ASTM D5293-15, such that the lubricating oil meets both kinematic viscosity (Kv100) and cold cranking simulator viscosity (CCSV) requirements for a SAE engine oil grade as determined by SAE J300 viscosity grade classification system.Type: ApplicationFiled: March 22, 2018Publication date: September 27, 2018Inventors: Raymond G. Burns, III, Smruti A. Dance, Douglas E. Deckman, Mark P. Hagemeister
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Publication number: 20180273871Abstract: A lubricant composition includes a perfluoropolyether as a base oil, a fluororesin as a thickener, and a polyol ester, a urea grease and a zinc dialkyldithiophosphate as additives, wherein a mass ratio of content of the perfluoropolyether to total content of the polyol ester and the urea grease ranges from 78/22 to 95/5, a mass ratio of content of the perfluoropolyether to content of the polyol ester ranges from 90/10 to 96.5/3.5, a mass ratio of content of the polyol ester to content of the urea grease ranges from 40/60 to 65/35, content of the fluororesin ranges from 15 mass % to 24 mass % based on a total amount of the lubricant composition, and content of the zinc dialkyldithiophosphate ranges from 0.5 mass % to 4 mass % based on the total amount of the lubricant composition.Type: ApplicationFiled: June 1, 2018Publication date: September 27, 2018Inventors: Takeshi HISHINUMA, Keita NAKASHI, Nobuaki IZAWA, Miwa KOMATSU
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Publication number: 20180273872Abstract: This disclosure relates to cold cranking simulator viscosity (“CCSV”) boosting base stocks that allow flexibility for engine oil formulations to meet both high and low temperature viscosity requirements while maximizing fuel efficiency. The CCSV-boosting base stocks can include C28-C60 hydrocarbon materials, linear esters, tertiary amides, dialkyl carbonates, aromatic alcohols, and aromatic ethers. This disclosure also relates to lubricating oil formulations containing the CCSV-boosting base stocks, and a method for improving fuel efficiency in an engine by using as engine oil a lubricating oil formulation containing one or more of the CCSV-boosting base stocks.Type: ApplicationFiled: February 26, 2018Publication date: September 27, 2018Inventors: Kyle G. Lewis, Patrick C. Chen, Mark P. Hagemeister, Omkar A. Namjoshi
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Publication number: 20180273873Abstract: A low S marine fuel trunk piston diesel engine lubricant includes an overbased metal detergent; a zinc dihydrocarbyl dithiophosphate; optionally an aminic antioxidant; and a borated ashless dispersant. The lubricant exhibits improved thermal and oxidative stability and improved high temperature detergency.Type: ApplicationFiled: March 22, 2018Publication date: September 27, 2018Applicant: Infineum International LimitedInventors: Adam P. Marsh, Jonathan M. Hughes
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Publication number: 20180273874Abstract: This disclosure relates to cold cranking simulator viscosity (“CCSV”) boosting base stocks that allow flexibility for engine oil formulations to meet both high and low temperature viscosity requirements while maximizing fuel efficiency. The CCSV-boosting base stocks can include C28-C60 hydrocarbon materials, linear esters, tertiary amides, dialkyl carbonates, aromatic alcohols, and aromatic ethers. This disclosure also relates to lubricating oil formulations containing the CCSV-boosting base stocks, and a method for determining the CCSV-boosting efficacy of a base stock.Type: ApplicationFiled: February 26, 2018Publication date: September 27, 2018Inventor: Kyle G. Lewis
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Publication number: 20180273875Abstract: This disclosure relates to cold cranking simulator viscosity (“CCSV”) boosting base stocks that allow flexibility for engine oil formulations to meet both high and low temperature viscosity requirements while maximizing fuel efficiency. The CCSV-boosting base stocks can include C28-C60 hydrocarbon materials, linear esters, tertiary amides, dialkyl carbonates, aromatic alcohols, and aromatic ethers. This disclosure also relates to lubricating oil formulations containing the CCSV-boosting base stocks, and a method for improving fuel efficiency in an engine by using as the engine oil a lubricating oil formulation containing one or more of the CCSV-boosting base stocks and/or cobase stocks.Type: ApplicationFiled: February 26, 2018Publication date: September 27, 2018Inventors: Kyle G. Lewis, Mark P. Hagemeister
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Publication number: 20180273876Abstract: To extract oil from oil seeds in a mechanical pressing operation, the oil seeds may be conditioned and then cooked before being subsequently pressed to release the oil contained in the seeds. In one application, a conditioning vessel is used that includes a shell through which the oil seeds move during operation and multiple heat transfer stages. Downstream of the conditioning vessel, a cooking vessel receives the oil seeds pre-conditioned in the conditioning vessel and cooks the oil seeds, generating a gas-containing stream that includes water vapor. The gas-containing stream is recycled back to one or more of the heat transfer stages of the conditioning vessel, providing direct heat transfer from the cooking vessel to the conditioning vessel. This arrangement can increase the energy efficiency of the operation and improve the performance of the system.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Inventors: Corey Alan Paulson, Benjamin Wayne Floan
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Publication number: 20180273877Abstract: Docosahexaenoic acid-containing oil containing docosahexaenoic acid in a concentration of 40 wt. % or more of the total weight of fatty acids in the oil, and having an endothermic peak temperature determined by differential scanning calorimetry (DSC) of 15° C. or lower; a biomass including the same; and a method for producing docosahexaenoic acid-containing oil including obtaining a biomass by culturing microorganisms of the genus Aurantiochytrium capable of producing this docosahexaenoic acid-containing oil, recovering the biomass after culture, and extracting the oil from the biomass after recovery.Type: ApplicationFiled: May 31, 2018Publication date: September 27, 2018Applicant: Nippon Suisan Kaisha, Ltd.Inventors: Takayoshi SEKIGUCHI, Yuji OKITA, Yumiko NISHIZAWA
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Publication number: 20180273878Abstract: The invention provides methods and compositions for recovering oil from stillage. The method comprises the addition of a surfactant and a microparticle comprising hydrophilic silica to a grain to ethanol stillage. The methods and compositions of the present invention release oil trapped in solid aggregates, increasing the total amount of oil extracted from the stillage.Type: ApplicationFiled: May 31, 2018Publication date: September 27, 2018Applicant: Ecolab USA Inc.Inventors: Lan Xiao, Xiaodong Huang, Xuejun Wang, Philip Eastin, Jason Van't Hul
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Publication number: 20180273879Abstract: A natural oil cover scent mixture containing a mixture of a base oil and a strong fragrance oil, cloaks and masks the odor of a hunter from detection by game animals being hunted, consisting primarily of a mixture of natural and beneficial topical oils, preferably jojoba oil, and a strong natural oil, primarily a cedar oil.Type: ApplicationFiled: March 16, 2018Publication date: September 27, 2018Inventor: Bradley Kyle Craig
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Publication number: 20180273880Abstract: A cleaner for silicon wafer and a method for cleaning silicon wafer are provided. The cleaner for silicon wafer is essentially consisted of 1-3 wt % of citric acid, 2.5-5 wt % of sodium bicarbonate, limonene, potassium hydroxide and water. The cleaning efficiency may be improved by using the cleaner for silicon wafer to clean the silicon wafer.Type: ApplicationFiled: January 11, 2018Publication date: September 27, 2018Applicant: Sino-American Silicon Products Inc.Inventors: Jian-Yu Lin, Chun-Ho Chen, I-Ching Li, Sung-Lin Hsu
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Publication number: 20180273881Abstract: The present disclosure relates to detergent compositions comprising polypeptides having xanthan degrading activity. The disclosure also relates to methods for producing said detergent compositions and to the use of said detergent compositions in cleaning applications.Type: ApplicationFiled: September 15, 2016Publication date: September 27, 2018Applicant: Henkel AG & Co. KGaAInventors: Timothy O'Connell, Susanne Tondera, Nina Mussmann, Daniela Herbst, Dorotea R.S. Raventos, Lars Anderson, Lorena Palmén, Liv Christiansen, Peter Hallin, Leigh Murphy, Mette Louise Dissing Overgaard, Rune Nygaard Monrad
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Publication number: 20180273882Abstract: Provided are various methods and systems for producing peroxycarboxylic acid compositions, and in particular, nonequilibrium compositions of peracetic acid. The methods and systems control flow rates and proportions of feedstocks/reactants, perform the required sequence of reaction steps to produce high yield peroxycarboxcylic acid solutions in a continuous manner, and provide optimal reaction time and reactant mixing for continuous and safe on-site production.Type: ApplicationFiled: June 1, 2018Publication date: September 27, 2018Applicant: Eltron Research & Development, LLCInventors: Andrew Del Negro, Paul Grimmer
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Publication number: 20180273883Abstract: Embodiments herein disclosed relate to a computer-controlled germination system built around a rotating vessel within which a germinating process takes place. The system includes automatable controls over air flow, water flow, temperature, and vessel rotation; and air and water recirculation mechanisms provide energy efficient control over air and water temperature, humidity, and/or CO2 content.Type: ApplicationFiled: May 25, 2018Publication date: September 27, 2018Inventors: William D. Redding, Wayne E. Carpenter
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Publication number: 20180273884Abstract: Method of production of a new kind of alcoholic drink, named Airag Vodka. Airag Vodka is made purely from fermented horse milk called kurnis. The production process includes distillation and two-stage filtering. The production process entails no use of outside water to the raw material. Airag Vodka is original. It is uniquely distinct both from the traditional kumis moonshines and from traditional kinds of vodka made from vegetable material.Type: ApplicationFiled: June 1, 2018Publication date: September 27, 2018Inventors: Nurbek Mukambetov, Emilbek Khudoyarov
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Publication number: 20180273885Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: ApplicationFiled: October 28, 2016Publication date: September 27, 2018Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20180273886Abstract: [Problem] It is an object to provide a biological tissue fabrication information generating device that generates biological tissue fabrication information for fabrication of tissue imitative of the structure of the biological tissue of a patient, a biological tissue fabrication system that fabricates biological tissue based on biological tissue fabrication information, and a medical expense calculation system that calculates the medical expense of a patient receiving therapeutic graft of biological tissue.Type: ApplicationFiled: September 5, 2016Publication date: September 27, 2018Applicant: KANEKA CORPORATIONInventors: Hirokazu AKIYAMA, Masaki ICHIMURA, Hirotoshi MATSUTA
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Publication number: 20180273887Abstract: In one aspect, the present disclosure provides a device. The device includes a body comprising a waterproof base, a waterproof coversheet attached to the base, and a channel disposed between the base and the coversheet. The channel has a perimeter and an opening that provides liquid access to the channel. A portion of the perimeter is defined by a waterproof seal. A dry first oxygen-scavenging reagent and an indicator reagent for detecting sulfate reduction by a sulfate-reducing bacterium are disposed in the device between the base and the coversheet. The waterproof base comprises a plurality of open microcompartment structures facing the coversheet.Type: ApplicationFiled: September 27, 2016Publication date: September 27, 2018Inventors: Evan D. Brutinel, Jason W. Bjork, Adam J. Stanenas
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Publication number: 20180273888Abstract: A microfluidic device includes a base comprising a chamber configured to receive a microfluidic component. A sealing member includes a body, an inlet reservoir, and an outlet reservoir, where the inlet reservoir and the outlet reservoir communicate with the chamber through fluid passages when the sealing member and base are removably coupled. A microfluidic component removably within the chamber includes microfluidic channels on a surface thereof and a tissue culture chamber coupled to at least one of the microfluidic channels. The microfluidic channels and the tissue culture chamber are in fluid communication with the inlet and outlet reservoirs through the fluid passages to form a fluid circuit for directing fluid from the inlet reservoir, through the tissue culture chamber, to the outlet reservoir, and from the outlet reservoir back to the inlet reservoir upon tilting the microfluidic device to a forward tilted position and to a reverse tilted position, respectively.Type: ApplicationFiled: October 3, 2016Publication date: September 27, 2018Inventor: Mandy Brigitte ESCH
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Publication number: 20180273889Abstract: Described is a device comprising an anchor, a tray including a well adapted to receive the anchor, and a cover adapted to engage the tray and cover the well. The device may be used to form a membrane-cell matrix having a substantially uniform distribution of the cells on the membrane in at least two dimensions.Type: ApplicationFiled: May 31, 2018Publication date: September 27, 2018Inventors: Yongzhong Wang, Christopher KELLY, Stephen RAPKO, Frank QUINNO, Barbara SEYMOUR
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Publication number: 20180273890Abstract: A lower chamber is to contain a culture that emits a volatile organic compound. A sensor is within an upper chamber. A transport accelerator/selector transports the volatile organic compound in the lower chamber towards the sensor.Type: ApplicationFiled: October 27, 2015Publication date: September 27, 2018Inventors: Viktor Shkolnikov, Anita Rogace
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Publication number: 20180273891Abstract: The present invention provides a stem cell manufacturing system comprising: a sending channel (20) through which a solution containing cells flows; an apparatus (30) which is connected to the sending channel (20) and transfers a pluripotency inducer into the cells to produce cells harboring the inducer; and an apparatus (40) which cultures the cells harboring the inducer to produce cell clusters consisting of stem cells.Type: ApplicationFiled: August 30, 2016Publication date: September 27, 2018Inventors: Koji TANABE, Brendan KELLY, Kenta SUTO
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Publication number: 20180273892Abstract: Herein described is an apparatus for disgregating a biological tissue, such as an adipose tissue including stem and/or multipotent cells for use in regenerative medicine. The apparatus comprises a disposable device having a first duct for the passage of the biological tissue, the first duct having a first end and a second end. Each end of the first duct is configured for connection to an inlet/outlet opening of a respective handling and/or collecting device, particularly a pump device, such as a syringe. The disposable device further comprises an adjustment arrangement operable to cause a reduction of a passage section of the first duct.Type: ApplicationFiled: September 22, 2016Publication date: September 27, 2018Applicant: ELTEK S.P.A.Inventors: Marco PIZZI, Massimo ZANIN, Enrica MORTARA
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Publication number: 20180273893Abstract: Disclosed herein are standardized and optimized, modular single-use kits and methods for sterile or non-sterile preparation of biological material, such as cells or tissue, for immediate use, further preparation, or storage. These single-use kits comprise at least one single-use component necessary for the preparation of biological material in accordance with a particular method as set forth in the instructions for use included with each particular type of single-use kit that set forth a unique method for using that particular type of single-use kit. The single-use kit of the invention comprises at least one modular, single-use packaging frame wherein at least one modular, single-use tray with an identifying is disposed, wherein at least one single-use component is organized. The identifying label on each modular single-use tray corresponds to (correlates with) a sequence of steps set forth in the instructions included with each single-use kit.Type: ApplicationFiled: May 30, 2018Publication date: September 27, 2018Inventors: GREGORY G. BENDIS, LESLIE E. FRILLING, JOHN D. MURRAY, ROBERT L. CAFFERATA, GARY A. GRANFIELD
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Publication number: 20180273894Abstract: The disclosure relates to the biotechnology field, and a method for preparing degradable materials, which comprises: inoculating Ceriporia lacerata into a culture medium containing lignocellulose debris for solid-state fermentation. The accession number of the C. lacerata is CGMCC No. 10485. The disclosure also relates to a degradable material obtained by the method and a method for cultivating the C. lacerata. The mycelia of the C. lacerata used herein can enwind and fix the culture medium debris (a lignocellulose material). By dint of the C. lacerata, the lignocellulose material can be prepared into a degradable material without sterilization or anti-bacterial treatment, and the preparation process doesn't require a sterile environment; thus, the preparation cost is decreased remarkably.Type: ApplicationFiled: March 21, 2017Publication date: September 27, 2018Applicant: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Wenxia Jiang, Ping Yang, Guobing Shao, Qi Liu
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Publication number: 20180273895Abstract: The present invention relates to novel Lactic Acid Bacteria strains Lactobacillus reuteri selected from the group comprising Lactobacillus reuteri DSM 32229, Lactobacillus reuteri DSM 32230, Lactobacillus reuteri DSM 32231 and Lactobacillus reuteri DSM 32232 and products comprising these strains. The present invention also relates to a use of one or more Lactic Acid Bacteria strains as a probiotic for the treatment of an inflammation and infection, such as mastitis and/or thrush, especially after topical administration of said strains.Type: ApplicationFiled: January 14, 2016Publication date: September 27, 2018Inventors: Bo Möllstam, Eamonn Connolly
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Publication number: 20180273896Abstract: A method of growing a microorganism by culturing the microorganism in a an aqueous solution of carbohydrates containing C6-sugar monomers or C5-sugar monomers, wherein the aqueous solution of carbohydrates is made by reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. The product mixture is then partitioned or extracted to yield an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone. The aqueous layer is used for growing the microorganisms.Type: ApplicationFiled: May 29, 2018Publication date: September 27, 2018Inventors: James A. Dumesic, Brian Pfleger, Jeremy S. Luterbacher, Jacqueline Rand
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Publication number: 20180273897Abstract: This invention provides ex vivo methods for making modified immune cell, e.g., T cell, compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof.Type: ApplicationFiled: September 16, 2016Publication date: September 27, 2018Inventors: Mark C. Poznansky, Fabrizio Vianello
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Publication number: 20180273898Abstract: The present invention provides a biological material including a parylene C film; and first proteins which are adsorbed on the surface of the parylene C film. According to an embodiment of the present invention, the biological material further includes second proteins different from the first proteins adsorbed on the surface of the parylene C film. According to an embodiment of the present invention, the first proteins or the second proteins include BMP-2, fibronectin or PRP.Type: ApplicationFiled: May 4, 2017Publication date: September 27, 2018Inventors: Hsien-Yeh Chen, Zhen-Yu Guan
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Publication number: 20180273899Abstract: A three-dimensional cell culture system that includes a keratin-based hydrogel precursor solution and a cell culture vessel is provided. The precursor solution includes solubilized keratin that has been functionalized to include a crosslinking moiety. The crosslinking moiety exhibits controllable crosslinking, e.g., a photopolymerizable crosslinking moiety. The crosslinking functionality is bonded to the keratin via cysteines following reduction of disulfide bonds of the native keratin. The precursor solution can be combined with cells to form a cell suspension that is disposed on a surface of the cell culture vessel. Alternatively, the cells can be added to a surface of a keratin-based hydrogel that has been formed on a surface of the cell culture vessel. The resulting three-dimensional cell culture system is a biomimetic/biologic, trypsin-degradable cell culture system for expansion of mammalian cells. The expanded cells are expected to possess a morphology similar to the primary cells prior to cultivation.Type: ApplicationFiled: November 16, 2017Publication date: September 27, 2018Inventor: Esmaiel Jabbari
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Publication number: 20180273900Abstract: There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. There is also provided a process for their preparation and several uses thereof.Type: ApplicationFiled: September 23, 2016Publication date: September 27, 2018Inventors: Luis Manuel LIZ-MARZÁN, Juan José GINER CASARES, Malou HENRIKSEN-LACEY, Alexander JOHNSON
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Publication number: 20180273901Abstract: This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.Type: ApplicationFiled: April 23, 2018Publication date: September 27, 2018Applicant: Stemcyte Inc.Inventors: Wise Young, Dongming Sun, Robert Fleischaker, Kam Sze Kent Tsang
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Publication number: 20180273902Abstract: The invention relates to mammalian haploid embryonic stem cells and methods for the production of such stem cells. The inventions also relates to a cell culture and a cell line of mammalian haploid embryonic stem cells.Type: ApplicationFiled: March 20, 2018Publication date: September 27, 2018Inventors: Anton WUTZ, Martin LEEB
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Publication number: 20180273903Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 28, 2017Publication date: September 27, 2018Applicant: Celularity, Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg