Patents Issued in October 9, 2018
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Patent number: 10093575Abstract: A method for continuous production of photo-sensitive glass bodies, glass bodies, and structured glass articles are provided. The glass bodies include a glass having Si4+, at least one crystal-agonist, at least one crystal-antagonist, and at least one pair of nucleating agents. The glass may be used in a method for structuring of glass. The glass bodies may be structured and/or unstructured and used in different applications such as in components or as components in micro-technology, in micro-reaction-technology, in electronic packaging, for micro-fluidic components, in or as FED spacer, for bio-technology (for example titer plates), as interposer, and in or as three-dimensional structurable antennae.Type: GrantFiled: May 18, 2016Date of Patent: October 9, 2018Assignee: SCHOTT AGInventors: Lothar Niessner, Martin Feichtinger, Carsten Renz, Bianca Schreder, Sean Qian, Junming Xue
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Patent number: 10093576Abstract: In order to address the technical problem of allowing an unshaped refractory material using a spinel-containing alumina cement to provide further improved corrosion resistance and slag infiltration resistance while reducing the occurrence of crack/peeling, an unshaped refractory material is provided which comprises a refractory raw material mixture having a particle size of 8 mm or less, with the refractory raw material mixture having an alumina cement at least a part of which is a spinel-containing alumina cement, and, with respect to 100 mass % of the refractory raw material mixture, the alumina cement contains CaO in an amount of 0.5 to 2.5 mass %, and the spinel-containing alumina cement contains spinel in an amount of 3.5 to 10.5 mass %.Type: GrantFiled: March 3, 2014Date of Patent: October 9, 2018Assignee: KROSAKIHARIMA CORPORATIONInventors: Koji Goda, Yoshihiro Sasatani, Koichi Uemura
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Patent number: 10093577Abstract: Provided is a fiber-reinforced carbonated hydraulic inorganic molded plate having a high bulk specific gravity, a high flexural strength, and a small dimensional change rate per specific gravity. (1) A fiber-reinforced carbonated hydraulic inorganic molded plate including: a cement component, a pulp, and a reinforcing fiber having an aspect ratio in a range of 40 to 1000; and being a carbonation-cured molded plate. (2) A molded plate being a cured product of a composition including at least a cement component, a pulp, and a reinforcing fiber, wherein the molded plate is a fiber-reinforced carbonated hydraulic inorganic molded plate and has a carbonation reaction rate of higher than or equal to 30%.Type: GrantFiled: May 3, 2016Date of Patent: October 9, 2018Assignee: KURARAY CO., LTD.Inventors: Yoshinori Hitomi, Shinya Inada, Yoshihiro Iwasaki, Hiroaki Noritake, Saburo Hada, Minoru Morioka, Takayuki Higuchi, Makoto Shoji, Katsuaki Iriuchijima
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Patent number: 10093578Abstract: Roadway maintenance and repair, and, in particular, to enhanced crack filler materials, systems, and methods for filling and repairing cracks in asphalt surfaces, such as asphalt roadways. The enhanced crack filler material includes crack filler and a silane additive. The silane additive includes organosilane, benzyl alcohol, and ethylene glycol. The crack filler can be a conventional crack filler material that, when combined with the silane additive, provide an enhanced crack filling material that enables improved crack filling operations, cleaning, and repair durability beyond conventional crack filler materials alone.Type: GrantFiled: June 29, 2017Date of Patent: October 9, 2018Inventor: Matthew Paul Elam
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Patent number: 10093579Abstract: The invention provides a process for the production of a cementitious material, comprising mixing cement starting materials, a healing agent and a fibrous reinforcing material, wherein the healing agent comprises bacterial material, and wherein the fibrous reinforcing material comprises a biodegradable polymer, having an average molecular weight selected from the range of 10-1500 kg/mol, and wherein the fibrous material comprises fibers having diameters selected from the range of 5-750 ?m, and having lengths selected from the range of 50 ?m-150 mm.Type: GrantFiled: July 17, 2015Date of Patent: October 9, 2018Assignee: GREEN-BASILISK B.V.Inventors: Hendrik Marius Jonkers, Reneé Maria Mors
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Patent number: 10093580Abstract: A refractory article can include a body including a content of alumina of at least 60 wt %, a content of silica of not greater than 20 wt %, a content of zirconia of not greater than 20 wt % for a total weight of the body. In a particular embodiment, the body includes a third phase including composite grains including mullite and zirconia. The third phase including the composite grains can be present within a range including at least 1 wt % and not greater than 35 wt % for a total weight of the body.Type: GrantFiled: July 31, 2017Date of Patent: October 9, 2018Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.Inventors: Allan R. Case, Edmund A. Cortellini, Hansong Huang, Melanie Kuhn, Nancy F. Levoy, Wesley S. Towle
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Patent number: 10093581Abstract: A batch made of refractory mineral materials for lining of assemblies used for nonferrous metal melts, contains over 90% by weight of a mixture of the following constituents:—from 3 to 74% by weight of at least one coarse-grain raw olivine material with at least 70% by weight forsterite content and having grain sizes of 50% by weight over 0.1 mm—from 25 to 49% by weight of at least one ground magnesia with grain sizes of 50% by weight?1 mm—from 0.9 to 14% by weight of at least one ground silicon carbide (SiC) with grain sizes of 50% by weight?1 mm—from 0.1 to 10% by weight of at least one fine-particle dry pulverulent silica with particle sizes?500 ?m—from 0 to 4% by weight of at least one antioxidant known per se for refractory products—from 0 to 4% by weight of at least one additional granulated refractory raw material known per se, more particularly having grain sizes of 50% by weight, in particular of 80% by weight, preferably of 100% by weight over 0.Type: GrantFiled: April 30, 2014Date of Patent: October 9, 2018Assignee: Refratechnik Holding GmbHInventors: Helge Jansen, Volker Stein, Thomas Schemmel
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Patent number: 10093582Abstract: Process for the moderately refractory assembly of at least two articles made of silicon carbide-based materials by non-reactive brazing in an oxidizing atmosphere, in which the articles are placed in contact with a non-reactive brazing composition and the assembly formed by the articles and the brazing composition is heated in an oxidizing atmosphere at a brazing temperature sufficient to melt the brazing composition so as to form a moderately refractory joint, wherein the non-reactive brazing composition is a composition A composed of silica (SiO2), alumina (Al2O3) and calcium oxide (CaO), or alternatively a composition B composed of alumina (Al2O3), calcium oxide (Cao) and magnesium oxide (MgO). Brazing suspension, paste comprising a powder of said brazing composition and an organic binder. Refractory joint and assembly.Type: GrantFiled: August 27, 2009Date of Patent: October 9, 2018Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Olivier Mailliart, Valérie Chaumat, Fiqiri Hodaj
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Patent number: 10093583Abstract: A process is described, for producing zirconia-based multi-phasic ceramic composite materials, comprising the steps of: providing at least one ceramic suspension by dispersing at least one ceramic zirconia powder in at least one aqueous medium to obtain at least one matrix for such composite material; providing at least one aqueous solution containing one or more inorganic precursors and adding such aqueous solution to such ceramic suspension to surface modify such ceramic zirconia powder and obtain at least one additived suspension; quickly drying such additived suspension to obtain at least one additived powder; heat treating such additived powder to obtain at least one zirconia powder coated on its surface by second phases; and forming such zirconia powder coated on its surface by second phases.Type: GrantFiled: February 13, 2015Date of Patent: October 9, 2018Assignees: Politecnico Di Torino, Centre National De La Recherche Scientifique, Decoram Medical Ceramica CMBH, Universite Claude Bernard Lyon, Institut National Des Sciences Appliquees De LyonInventors: Laura Montanaro, Paola Palmero, Jerome Chevalier, Helen Reveron, Tobias Fuerderer
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Patent number: 10093584Abstract: Polymer-derived ceramic composites are described herein. The composites are formed using hexagonal boron nitride nanosheet-functionalized silicon-based ceramic precursor polymers. The composites a matrix of a polymer-derived ceramic and hexagonal boron nitride nanosheets embedded therein. Silicon-derived ceramic precursors such as polysilazane and/or polysiloxane are used to create improved SiCN and/or SiOC ceramic composites.Type: GrantFiled: July 8, 2015Date of Patent: October 9, 2018Assignee: Kansas State University Research FoundationInventors: Gurpreet Singh, Lamuel David
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Patent number: 10093585Abstract: A method of preparing a fiber for use in forming a ceramic matrix composite material comprises the steps of removing an organic sizing from a fiber to provide pyrolyzed remnants on the fiber, and using the pyrolyzed remnants as a reactant to provide an interface coating on the fiber.Type: GrantFiled: May 14, 2015Date of Patent: October 9, 2018Assignee: United Technologies CorporationInventors: Paul Sheedy, Neal Magdefrau
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Patent number: 10093586Abstract: A method for forming a ceramic matrix composite article includes forming by melt infiltration a ceramic matrix composite substrate inducing a ceramic fiber reinforcement material in a ceramic matrix material having a free silicon proportion and forming by chemical vapor infiltration a ceramic matrix composite outer layer including a ceramic fiber reinforcement material in a ceramic matrix material having no free silicon proportion disposed on at least a portion of the substrate.Type: GrantFiled: February 26, 2015Date of Patent: October 9, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Krishan Lal Luthra, Gregory Scot Corman, Badri Narayan Ramamurthi
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Patent number: 10093587Abstract: In a process for manufacturing foamed material an expansion agent, a ceramic base material and water are blended together. The blend is heated and pressurized to homogenize and liquefy or plasticize it. The blend is then extruded through a die where, in the course of the extrusion, superheated water in the blend vaporizes to foam the blend. To make articles of manufacture, extrudate is cut to length, machined and fired, or is injection molded while still malleable and then fired.Type: GrantFiled: June 18, 2014Date of Patent: October 9, 2018Inventors: Robin Crawford, John Douglas
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Patent number: 10093588Abstract: A method is described for rendering char from a biomass fractionator apparatus (BMF char) suitable for addition to soil in high concentrations, the method relying on multiple processes comprising removing detrimental hydrocarbons from BMF char, removing adsorbed gases from BMF char, introducing microorganisms to the BMF char, and adjusting soil pH.Type: GrantFiled: November 14, 2016Date of Patent: October 9, 2018Assignee: COOL PLANET ENERGY SYSTEMS, INC.Inventors: Michael C. Cheiky, Mark L. Jarand, Ronald A. Sills
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Patent number: 10093589Abstract: Disclosed is a stable fertilizer composition including: a sulfur-containing compound; and a reaction product of a potassium-containing compound and a humectant selected from the group consisting of polyhydric alcohols, esters of polyhydric alcohols, polyalkylene glycols, and hydroxylated carboxylic acids. One version of the fertilizer composition also includes a nitrogen-containing compound; a phosphorous-containing compound; and at least one more additional macronutrient or micronutrient. The macronutrient may be selected from the group consisting of calcium and magnesium, and the micronutrient may be selected from the group consisting of zinc, manganese, iron, copper, calcium, magnesium, cobalt, boron, nickel, and molybdenum. The fertilizer composition may be essentially free of chelated metals and chelated metal salts. Methods of using a solution of the fertilizer composition for supplying plant nutrients to a plant are also disclosed.Type: GrantFiled: February 23, 2016Date of Patent: October 9, 2018Assignee: HYDRITE CHEMICAL CO.Inventors: Dean Blankenburg, Eric M. Johnson, Charles A. Krier
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Patent number: 10093590Abstract: The present disclosure provides a method for treating a solid fertilizer. The method comprises contacting the solid fertilizer with an amount of a liquid composition effective for reducing clumping in the fertilizer caused by absorption of water. The liquid composition may comprise one or more organic solvents and/or petroleum distillates. The organic solvents may be selected from the group consisting of glycol, dialkylcarbonate, C1-C4 alcohol, vegetable oil, esters of hydroxyacids, heterocyclic alcohols, cyclic esters of carbonic acid, and esters of dicarboxyacids.Type: GrantFiled: November 14, 2014Date of Patent: October 9, 2018Assignee: AgXplore International, LLCInventor: Paul Hayes
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Patent number: 10093591Abstract: A method of characterizing the structure of a void sensitized liquid energetic material, which method comprises defining the material in terms distribution function, the distribution function representing the fraction of liquid energetic material that occurs at a given point within the void sensitized liquid energetic material.Type: GrantFiled: December 13, 2012Date of Patent: October 9, 2018Assignee: Orica International Pte LtdInventors: John Cooper, Ian John Kirby, Vladimir Sujansky, Sek K Chan
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Patent number: 10093592Abstract: A combustible element includes regions of fuel material interspersed with regions of oxidizer material. The element may be made by additive manufacturing processes, such as three-dimensional printing, with the fuel material regions and the oxidizer material regions placed in appropriate locations in layer of the combustible element. For example, different extruders may be used to extrude and deposit portions of a fuel filament and an oxidizer filament at different locations in each layer of the combustible element. The combustible element may define a combustion chamber within the element, where combustion occurs when the combustible element is ignited. The fuel material and the oxidizer material may be selected, and their relative amounts may be controlled, such that desired relative amounts of fuel and oxidizer are present for combustion with desired characteristics, such as combustion rate.Type: GrantFiled: June 3, 2015Date of Patent: October 9, 2018Assignee: Raytheon CompanyInventors: Jeremy C. Danforth, Mark T. Langhenry, Matt H. Summers, Teresa Perdue
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Patent number: 10093593Abstract: A process is presented for generating light olefins with the methanol to olefins process from a combination of catalysts. The process controls the product distribution for ethylene, propylene and butylenes, to enable shifting of the product distribution. The process includes passing a second catalyst to a reactor while the process is on-going.Type: GrantFiled: June 8, 2017Date of Patent: October 9, 2018Assignee: UOP LLCInventors: Gregory A. Funk, Andrea G. Bozzano, Nicholas J. Schoenfeldt, Thulasidas Chellppannair, Wolfgang A. Spieker, Bipin V. Vora
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Patent number: 10093594Abstract: An isoalkane alkylate base oil and a process to make an isoalkane alkylate base oil having a VI higher than 90, comprising: a. selecting an isoalkane feed containing at least one isoalkane and an olefin feed containing at least one linear olefin such that a combined carbon number of the isoalkane feed and the olefin feed is from 20 to 60; and b. alkylating the isoalkane feed with the olefin feed in the presence of an acidic alkylation catalyst under alkylation conditions to make the isoalkane alkylate base oil having the VI higher than 90; wherein the isoalkane alkylate base oil has a kinematic viscosity at 100° C. from 2 to 30 mm2/s, a pour point less than 0° C., and a bromine index less than 2000 mg Br/100 g.Type: GrantFiled: May 19, 2016Date of Patent: October 9, 2018Assignee: Chevron U.S.A. Inc.Inventor: Sven Ivar Hommeltoft
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Patent number: 10093595Abstract: A process of catalytically dehydrogenating an alkane to an alkene, using Cr2O3 as a catalyst, where the catalyst is reduced concurrently with the dehydrogenation by using CO as a reducing gas. In reducing the catalyst with CO, CO2 is produced, which may be reacted with H2 produced by the dehydrogenation, to form CO and H2O by the reverse water-gas shift reaction. A Cu O heat-releasing material may be included with the catalyst in the reactor. The CO reducing gas reduces CuO to form Cu and CO2, releasing heat. The CO2 produced by reducing the Cu O may also be reacted with H2 produced by the dehydrogenation, to form CO and H2O by the reverse water-gas shift reaction.Type: GrantFiled: November 25, 2015Date of Patent: October 9, 2018Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: YongMan Choi, Ramsey Bunama, Khalid M. El-Yahyaoui
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Patent number: 10093596Abstract: The present invention is, in a first embodiment, a process for removing oxygenated contaminants from an ethylene stream comprising: a) providing a dried ethylene stream (A) comprising essentially ethylene, up to 1 w % oxygenates, ethane, CO, CO2, H2, CH4 and C3+ hydrocarbons, b) sending said stream (A) to a stripper (also referred to as a demethanizer) to produce an overhead stream comprising essentially CO, H2 and CH4, a bottom stream comprising essentially ethylene, oxygenates, ethane, CO2 and C3+ hydrocarbons, c) sending said bottom stream of step b) to a deethanizer to produce a bottom stream comprising essentially ethane, oxygenates and C3+ hydrocarbons, an overhead stream consisting essentially of ethylene and CO2, d) sending said overhead of step c) to a fixed bed CO2 adsorption zone to recover an ethylene stream essentially free of CO2. In another embodiment the CO2 adsorption zone can be located at the inlet of the deethanizer. In another embodiment the demethanizer is replaced by two demethanizers.Type: GrantFiled: April 5, 2018Date of Patent: October 9, 2018Assignees: Total Research & Technology Feluy, IFP Energies NouvellesInventors: Babua Das, Manuela Arratia, Catherine Boutrot
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Patent number: 10093597Abstract: In a process for separating one or more 3,3?-, 3,4?- and 4,4?-dimethyl biphenyl isomers, a feed comprising the isomers is contacted with an adsorbent containing a zeolite having a largest diffuse along dimension of at least 4 Angstroms. The adsorbents provide selective adsorption of 4,4?-dimethyl biphenyl.Type: GrantFiled: February 1, 2018Date of Patent: October 9, 2018Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Changyub Paek, Michael P. Lanci, Randall D. Partridge, Allen W. Burton, Peter I. Ravikovitch, Sumathy Raman
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Patent number: 10093598Abstract: A process is described for separating paraxylene from a multicomponent fluid mixture of C8 aromatics. A mixture of C8 aromatics is fed to a simulated moving-bed adsorptive apparatus. The location of the feed to the apparatus is moved at set intervals. The rate of flow of feed to the apparatus is varied during each interval to enhance the separation of paraxylene from the multicomponent mixture.Type: GrantFiled: December 28, 2015Date of Patent: October 9, 2018Assignees: EXXONMOBIL CHEMICAL PATENTS INC., GEORGIA TECH RESEARCH CORPORATIONInventors: John D. Ou, Jeevan S. Abichandani, Yoshiaki Kawajiri, Siwei Guo
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Patent number: 10093599Abstract: The present invention is a method for producing a fluorinated hydrocarbon represented by a structural formula (3), wherein an ether compound represented by a structural formula (1) and an acid fluoride represented by a structural formula (2) are brought into contact with each other in a hydrocarbon-based solvent, in the presence of a catalyst in which boron trifluoride is supported on a metal oxide: wherein R1 and R2 represent an alkyl group having 1 to 3 carbon atoms, R3 represents a hydrogen atom, a methyl group or an ethyl group, and R4 and R5 represent a methyl group or an ethyl group; and R1 and R2 may be bonded to each other to form a cyclic structure. Through the present invention, a method for industrially advantageously producing 2-fluorobutane is provided.Type: GrantFiled: July 26, 2016Date of Patent: October 9, 2018Assignee: ZEON CORPORATIONInventor: Tatsuya Sugimoto
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Patent number: 10093600Abstract: A method to efficiently and stably produce trifluoroethylene from 1,1,1,2-tetrafluoroethane is provided. In the method, a material gas containing 1,1,1,2-tetrafluoroethane in a gaseous phase and calcium oxide in a solid phase are brought into contact with each other in a reactor. Clogging of the reactor is less likely to occur, the load of the moisture removal process is light, and problems such as a decrease in the yield of trifluoroethylene do not arise.Type: GrantFiled: July 25, 2016Date of Patent: October 9, 2018Assignee: AGC Inc.Inventors: Masahiko Nakamura, Hidekazu Okamoto
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Patent number: 10093601Abstract: Compounds with fire extinguishing properties having the formula: wherein R1 is —CR5R6R7 or —CR5R6CR8R9R10 as well as fire extinguishing units including one or more of the compounds.Type: GrantFiled: June 29, 2015Date of Patent: October 9, 2018Assignee: The Boeing CompanyInventors: Kimberly-Alice D. Gregersen, James Craig Moreland, Ekaterina A. Badaeva, Andrew M. Zweig
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Patent number: 10093602Abstract: The invention provides a process for the catalytic conversion of a saccharide-containing feedstock in a reactor, wherein saccharide-containing feedstock is provided to the reactor as a feed stream through a feed pipe and is contacted with a catalyst system in the reactor and wherein, as the saccharide-containing feedstock is fed through the feed pipe, a solvent stream, initially comprising essentially no saccharide, is fed along the internal walls of the feed pipe.Type: GrantFiled: September 9, 2015Date of Patent: October 9, 2018Assignee: SHELL OIL COMPANYInventors: Evert Van Der Heide, Pieter Huizenga
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Patent number: 10093603Abstract: The present disclosure relates to an apparatus for generating glycol and a method thereof. More particularly, the present disclosure relates to an apparatus for generating glycol including (a) an aldol reactor; (b) an extractor for extracting an aldol product, unsaturated aldehyde, using an organic solvent that is not mixed with water; (c) a distillation column for removing a raw material from a solution extract that is discharged from the extractor; (d) a hydrogenation reactor for hydrogenating a solution extract that is discharged from the distillation column; and (e) a divided-wall distillation column for isolating glycol from a hydrogenated solution product that is discharged from the hydrogenation reactor, wherein the hydrogenation reactor is a fixed-bed catalytic reactor that is filled with a copper-based catalyst, and a method of preparing the same.Type: GrantFiled: August 25, 2016Date of Patent: October 9, 2018Assignee: LG Chem, Ltd.Inventors: Sung Shik Eom, Da Won Jung, Tae Yun Kim, Jung Uk Choi, Dong Hyun Ko, Mi Young Kim, Min Ji Choi
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Patent number: 10093604Abstract: Novel heterocyclic selenabisphosphites, process for preparation thereof and use thereof as ligand unit for preparing ligands for use in complexes.Type: GrantFiled: December 6, 2016Date of Patent: October 9, 2018Assignee: EVONIK DEGUSSA GMBHInventors: Katrin Marie Dyballa, Robert Franke, Claudia Weilbeer, Detlef Selent, Armin Börner
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Patent number: 10093605Abstract: The present invention provides a novel process for producing 2,6,6-trimethyl-2-cyclohexene-1,4-dione (keto-isophorone) by catalytic oxidation of 3,5,5-trimethylcyclohexa-3-ene-1-one (?-isophorone) with hydrogen peroxide as the oxidant. In particular, the novel process includes phase transfer reagent in a biphasic system including an organic phase and an aqueous phase wherein the biphasic system includes 1) a tungsten polyoxyometallate as catalyst and hydrogen peroxide, and/or 2) a mixture of a) a mineral acid, b) hydrogen peroxide, and c) a metal tungstate.Type: GrantFiled: November 27, 2017Date of Patent: October 9, 2018Assignee: Evonik Degussa GmbHInventors: Stephanie Bajus, Jan Caßens, Jens Döring, Jörg-Joachim Nitz, Stephan Kohlstruk, Robert Jansen
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Patent number: 10093606Abstract: The present invention relates to a process for preparing farnesyl acetone.Type: GrantFiled: April 29, 2015Date of Patent: October 9, 2018Assignee: BASF SE (REITSTÖTTER, KINZEBACH & PARTNER)Inventors: Mathias Schelwies, Rocco Paciello, Heinz Eckhardt, Martine Dehn
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Patent number: 10093607Abstract: The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R?, wherein R? is —(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR?, wherein X is an alkali metal, and R? is defined as above.Type: GrantFiled: October 2, 2014Date of Patent: October 9, 2018Assignee: BASF SEInventors: Eric George Klauber, Michael Rack, Thomas Zierke, Nicole Holub, David Cortes, Gerald Schmelebeck, Junmin Ji
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Patent number: 10093608Abstract: The invention pertains to a method for preparing succinic acid which comprises providing an aqueous magnesium succinate solution to an acidification step, wherein the magnesium succinate solution is acidified by the addition of hydrogen chloride, thereby obtaining an aqueous solution comprising succinic acid and magnesium chloride and subjecting the aqueous solution comprising succinic acid and magnesium chloride derived from the acidification step to a treatment step with active carbon followed by precipitating succinic acid from an aqueous mixture comprising succinic acid and magnesium chloride resulting from the active carbon treatment step in a precipitation step to form solid succinic acid. It has been found that the method according to the invention leads to succinic acid crystals with better properties than a comparable method wherein no active carbon treatment is used.Type: GrantFiled: July 14, 2016Date of Patent: October 9, 2018Assignee: PURAC BIOCHEM B.V.Inventors: Jan Van Breugel, Peter Paul Jansen, Jose Maria Vidal Lancis, Tanja Dekic Zivkovic, Adriaan Dirk Kon
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Patent number: 10093609Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.Type: GrantFiled: September 4, 2017Date of Patent: October 9, 2018Assignee: Emory UniversityInventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
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Patent number: 10093610Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.Type: GrantFiled: September 14, 2017Date of Patent: October 9, 2018Assignee: DIPHARMA S.A.Inventor: Emanuele Attolino
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Patent number: 10093611Abstract: The present invention relates to fungicidal benzocycloalkene carboxamides or their thiocarboxamide derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.Type: GrantFiled: September 30, 2015Date of Patent: October 9, 2018Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Juergen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Ulrike Wachendorff-Neumann
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Patent number: 10093612Abstract: The present invention relates to a process to prepare N,N?-di(2-hydroxybenzyl) ethylenediamine-N,N?-diacetic acid and salts thereof comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof and phenol at a pH of between 3 and 7 and a temperature below 60° C. wherein the reaction mixture contains 0.2 to 1.1 molar equivalents of alkali metalions on the molar amount of EDDA.Type: GrantFiled: June 23, 2016Date of Patent: October 9, 2018Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Adrianus Maria Reichwein, Hubertus Johannes Jongen, Marjolein Groote
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Patent number: 10093613Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: GrantFiled: December 4, 2017Date of Patent: October 9, 2018Assignees: GTX, INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Charles B. Duke, Christopher C. Coss, Amanda Jones, James T. Dalton
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Patent number: 10093614Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: GrantFiled: June 6, 2017Date of Patent: October 9, 2018Assignee: REATA PHARMACEUTICALS, INC.Inventors: Eric Anderson, Xin Jiang, Melean Visnick
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Patent number: 10093615Abstract: The invention relates to a process for preparing isocyanates by reacting primary amines with phosgene in a solvent, where the solvent comprises a dialkyl carbonate.Type: GrantFiled: April 21, 2015Date of Patent: October 9, 2018Assignee: BASF SEInventors: Manfred Heilig, Thomas Schulz, Torsten Mattke, Filip Nevejans, Kai Thiele, Stefan Maixner
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Patent number: 10093616Abstract: Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.Type: GrantFiled: August 16, 2016Date of Patent: October 9, 2018Assignee: THERACOS SUB, LLCInventors: Jacques Roberge, Carine Vaxelaire, Baohu Liu, Ge Xu, Jian Zhang, Xinxing Tang, Baihua Xu
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Patent number: 10093617Abstract: A compound represented by formula (3): (wherein R1 represents a C1-C6 alkyl group optionally having one or more halogen atoms, R2 represents a C1-C6 alkyl group, and m represents an integer of 0 to 3) can be produced by reacting a C1-C6 alkanesulfinic acid salt optionally having one or more halogen atoms with a compound represented by formula (2): (wherein R2 and m are as defined above) in the presence of a protonic acid.Type: GrantFiled: October 10, 2016Date of Patent: October 9, 2018Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Junichi Ishikawa, Yuta Honda
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Patent number: 10093618Abstract: The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acceptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.Type: GrantFiled: July 23, 2014Date of Patent: October 9, 2018Assignee: Avexxin ASInventors: Marcel Sanderberg, Inger-Reidun Aukrust
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Patent number: 10093619Abstract: A method of producing an organopolysulfide or salt thereof is provided which includes a step of mixing an organomonosulfide or salt thereof and elemental sulfur, wherein the mixing is carried out at a temperature not greater than 95 C and in the absence of any added liquid phase for a time effective to produce the organopolysulfide or salt thereof. The described method makes possible the preparation of organopolysulfides and organopolysulfide salts without the use of solvent or catalyst.Type: GrantFiled: April 29, 2016Date of Patent: October 9, 2018Assignee: Arkema Inc.Inventors: George C. Fortman, Gary S. Smith
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Patent number: 10093620Abstract: Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.Type: GrantFiled: September 11, 2015Date of Patent: October 9, 2018Assignee: PELLFICURE PHARMACEUTICALS, INC.Inventors: Per Borgström, Adrian Chrastina, Veronique Therese Baron, Parisa Abedinpour
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Patent number: 10093621Abstract: The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is —COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO— wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.Type: GrantFiled: September 16, 2015Date of Patent: October 9, 2018Assignee: FONDAZIONE IRCCS INSTITUTO NAZIONALE DEI TUMORIInventors: Maria Grazia Daidone, Valentina Appierto, Paola Tiberio, Sabrina Dallavalle, Loana Musso, Elisa Niccolini
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Patent number: 10093622Abstract: Disclosed herein is an efficient, economical, industrially advantageous, straight-through process for the preparation of cyclic amides, also referred as lactams, in substantially pure form and high yield, from the corresponding cyclic ketones and a hydroxylammonium salt, using a combination of amphoteric metal oxide or amphoteric masked metal oxide and a base.Type: GrantFiled: June 4, 2015Date of Patent: October 9, 2018Assignee: ANTHEA AROMATICS PRIVATE LIMITEDInventors: Manoj Kumar Mohapatra, Ramamohanrao Bendapudi, Paul Vincent Menacherry, Vincent Paul
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Patent number: 10093623Abstract: Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.Type: GrantFiled: March 21, 2013Date of Patent: October 9, 2018Assignee: MERCK PATENT GmbHInventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
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Patent number: 10093624Abstract: Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.Type: GrantFiled: October 12, 2015Date of Patent: October 9, 2018Assignee: AbbVie Inc.Inventors: Rick F. Clark, Michael L. Curtain, Todd M. Hansen, Howard R. Heyman, Helmut Mack, Michael Michaelides, Marina A. Pliushchev, Omar J. Shah, Bryan K. Sorensen, Ramzi Sweis, Chris Tse, Anil Vasudevan, Kevin R. Woller