Patents Issued in October 9, 2018
  • Patent number: 10093575
    Abstract: A method for continuous production of photo-sensitive glass bodies, glass bodies, and structured glass articles are provided. The glass bodies include a glass having Si4+, at least one crystal-agonist, at least one crystal-antagonist, and at least one pair of nucleating agents. The glass may be used in a method for structuring of glass. The glass bodies may be structured and/or unstructured and used in different applications such as in components or as components in micro-technology, in micro-reaction-technology, in electronic packaging, for micro-fluidic components, in or as FED spacer, for bio-technology (for example titer plates), as interposer, and in or as three-dimensional structurable antennae.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: October 9, 2018
    Assignee: SCHOTT AG
    Inventors: Lothar Niessner, Martin Feichtinger, Carsten Renz, Bianca Schreder, Sean Qian, Junming Xue
  • Patent number: 10093576
    Abstract: In order to address the technical problem of allowing an unshaped refractory material using a spinel-containing alumina cement to provide further improved corrosion resistance and slag infiltration resistance while reducing the occurrence of crack/peeling, an unshaped refractory material is provided which comprises a refractory raw material mixture having a particle size of 8 mm or less, with the refractory raw material mixture having an alumina cement at least a part of which is a spinel-containing alumina cement, and, with respect to 100 mass % of the refractory raw material mixture, the alumina cement contains CaO in an amount of 0.5 to 2.5 mass %, and the spinel-containing alumina cement contains spinel in an amount of 3.5 to 10.5 mass %.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: October 9, 2018
    Assignee: KROSAKIHARIMA CORPORATION
    Inventors: Koji Goda, Yoshihiro Sasatani, Koichi Uemura
  • Patent number: 10093577
    Abstract: Provided is a fiber-reinforced carbonated hydraulic inorganic molded plate having a high bulk specific gravity, a high flexural strength, and a small dimensional change rate per specific gravity. (1) A fiber-reinforced carbonated hydraulic inorganic molded plate including: a cement component, a pulp, and a reinforcing fiber having an aspect ratio in a range of 40 to 1000; and being a carbonation-cured molded plate. (2) A molded plate being a cured product of a composition including at least a cement component, a pulp, and a reinforcing fiber, wherein the molded plate is a fiber-reinforced carbonated hydraulic inorganic molded plate and has a carbonation reaction rate of higher than or equal to 30%.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: October 9, 2018
    Assignee: KURARAY CO., LTD.
    Inventors: Yoshinori Hitomi, Shinya Inada, Yoshihiro Iwasaki, Hiroaki Noritake, Saburo Hada, Minoru Morioka, Takayuki Higuchi, Makoto Shoji, Katsuaki Iriuchijima
  • Patent number: 10093578
    Abstract: Roadway maintenance and repair, and, in particular, to enhanced crack filler materials, systems, and methods for filling and repairing cracks in asphalt surfaces, such as asphalt roadways. The enhanced crack filler material includes crack filler and a silane additive. The silane additive includes organosilane, benzyl alcohol, and ethylene glycol. The crack filler can be a conventional crack filler material that, when combined with the silane additive, provide an enhanced crack filling material that enables improved crack filling operations, cleaning, and repair durability beyond conventional crack filler materials alone.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 9, 2018
    Inventor: Matthew Paul Elam
  • Patent number: 10093579
    Abstract: The invention provides a process for the production of a cementitious material, comprising mixing cement starting materials, a healing agent and a fibrous reinforcing material, wherein the healing agent comprises bacterial material, and wherein the fibrous reinforcing material comprises a biodegradable polymer, having an average molecular weight selected from the range of 10-1500 kg/mol, and wherein the fibrous material comprises fibers having diameters selected from the range of 5-750 ?m, and having lengths selected from the range of 50 ?m-150 mm.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: October 9, 2018
    Assignee: GREEN-BASILISK B.V.
    Inventors: Hendrik Marius Jonkers, Reneé Maria Mors
  • Patent number: 10093580
    Abstract: A refractory article can include a body including a content of alumina of at least 60 wt %, a content of silica of not greater than 20 wt %, a content of zirconia of not greater than 20 wt % for a total weight of the body. In a particular embodiment, the body includes a third phase including composite grains including mullite and zirconia. The third phase including the composite grains can be present within a range including at least 1 wt % and not greater than 35 wt % for a total weight of the body.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 9, 2018
    Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.
    Inventors: Allan R. Case, Edmund A. Cortellini, Hansong Huang, Melanie Kuhn, Nancy F. Levoy, Wesley S. Towle
  • Patent number: 10093581
    Abstract: A batch made of refractory mineral materials for lining of assemblies used for nonferrous metal melts, contains over 90% by weight of a mixture of the following constituents:—from 3 to 74% by weight of at least one coarse-grain raw olivine material with at least 70% by weight forsterite content and having grain sizes of 50% by weight over 0.1 mm—from 25 to 49% by weight of at least one ground magnesia with grain sizes of 50% by weight?1 mm—from 0.9 to 14% by weight of at least one ground silicon carbide (SiC) with grain sizes of 50% by weight?1 mm—from 0.1 to 10% by weight of at least one fine-particle dry pulverulent silica with particle sizes?500 ?m—from 0 to 4% by weight of at least one antioxidant known per se for refractory products—from 0 to 4% by weight of at least one additional granulated refractory raw material known per se, more particularly having grain sizes of 50% by weight, in particular of 80% by weight, preferably of 100% by weight over 0.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: October 9, 2018
    Assignee: Refratechnik Holding GmbH
    Inventors: Helge Jansen, Volker Stein, Thomas Schemmel
  • Patent number: 10093582
    Abstract: Process for the moderately refractory assembly of at least two articles made of silicon carbide-based materials by non-reactive brazing in an oxidizing atmosphere, in which the articles are placed in contact with a non-reactive brazing composition and the assembly formed by the articles and the brazing composition is heated in an oxidizing atmosphere at a brazing temperature sufficient to melt the brazing composition so as to form a moderately refractory joint, wherein the non-reactive brazing composition is a composition A composed of silica (SiO2), alumina (Al2O3) and calcium oxide (CaO), or alternatively a composition B composed of alumina (Al2O3), calcium oxide (Cao) and magnesium oxide (MgO). Brazing suspension, paste comprising a powder of said brazing composition and an organic binder. Refractory joint and assembly.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: October 9, 2018
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Olivier Mailliart, Valérie Chaumat, Fiqiri Hodaj
  • Patent number: 10093583
    Abstract: A process is described, for producing zirconia-based multi-phasic ceramic composite materials, comprising the steps of: providing at least one ceramic suspension by dispersing at least one ceramic zirconia powder in at least one aqueous medium to obtain at least one matrix for such composite material; providing at least one aqueous solution containing one or more inorganic precursors and adding such aqueous solution to such ceramic suspension to surface modify such ceramic zirconia powder and obtain at least one additived suspension; quickly drying such additived suspension to obtain at least one additived powder; heat treating such additived powder to obtain at least one zirconia powder coated on its surface by second phases; and forming such zirconia powder coated on its surface by second phases.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: October 9, 2018
    Assignees: Politecnico Di Torino, Centre National De La Recherche Scientifique, Decoram Medical Ceramica CMBH, Universite Claude Bernard Lyon, Institut National Des Sciences Appliquees De Lyon
    Inventors: Laura Montanaro, Paola Palmero, Jerome Chevalier, Helen Reveron, Tobias Fuerderer
  • Patent number: 10093584
    Abstract: Polymer-derived ceramic composites are described herein. The composites are formed using hexagonal boron nitride nanosheet-functionalized silicon-based ceramic precursor polymers. The composites a matrix of a polymer-derived ceramic and hexagonal boron nitride nanosheets embedded therein. Silicon-derived ceramic precursors such as polysilazane and/or polysiloxane are used to create improved SiCN and/or SiOC ceramic composites.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: October 9, 2018
    Assignee: Kansas State University Research Foundation
    Inventors: Gurpreet Singh, Lamuel David
  • Patent number: 10093585
    Abstract: A method of preparing a fiber for use in forming a ceramic matrix composite material comprises the steps of removing an organic sizing from a fiber to provide pyrolyzed remnants on the fiber, and using the pyrolyzed remnants as a reactant to provide an interface coating on the fiber.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: October 9, 2018
    Assignee: United Technologies Corporation
    Inventors: Paul Sheedy, Neal Magdefrau
  • Patent number: 10093586
    Abstract: A method for forming a ceramic matrix composite article includes forming by melt infiltration a ceramic matrix composite substrate inducing a ceramic fiber reinforcement material in a ceramic matrix material having a free silicon proportion and forming by chemical vapor infiltration a ceramic matrix composite outer layer including a ceramic fiber reinforcement material in a ceramic matrix material having no free silicon proportion disposed on at least a portion of the substrate.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 9, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Krishan Lal Luthra, Gregory Scot Corman, Badri Narayan Ramamurthi
  • Patent number: 10093587
    Abstract: In a process for manufacturing foamed material an expansion agent, a ceramic base material and water are blended together. The blend is heated and pressurized to homogenize and liquefy or plasticize it. The blend is then extruded through a die where, in the course of the extrusion, superheated water in the blend vaporizes to foam the blend. To make articles of manufacture, extrudate is cut to length, machined and fired, or is injection molded while still malleable and then fired.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: October 9, 2018
    Inventors: Robin Crawford, John Douglas
  • Patent number: 10093588
    Abstract: A method is described for rendering char from a biomass fractionator apparatus (BMF char) suitable for addition to soil in high concentrations, the method relying on multiple processes comprising removing detrimental hydrocarbons from BMF char, removing adsorbed gases from BMF char, introducing microorganisms to the BMF char, and adjusting soil pH.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: October 9, 2018
    Assignee: COOL PLANET ENERGY SYSTEMS, INC.
    Inventors: Michael C. Cheiky, Mark L. Jarand, Ronald A. Sills
  • Patent number: 10093589
    Abstract: Disclosed is a stable fertilizer composition including: a sulfur-containing compound; and a reaction product of a potassium-containing compound and a humectant selected from the group consisting of polyhydric alcohols, esters of polyhydric alcohols, polyalkylene glycols, and hydroxylated carboxylic acids. One version of the fertilizer composition also includes a nitrogen-containing compound; a phosphorous-containing compound; and at least one more additional macronutrient or micronutrient. The macronutrient may be selected from the group consisting of calcium and magnesium, and the micronutrient may be selected from the group consisting of zinc, manganese, iron, copper, calcium, magnesium, cobalt, boron, nickel, and molybdenum. The fertilizer composition may be essentially free of chelated metals and chelated metal salts. Methods of using a solution of the fertilizer composition for supplying plant nutrients to a plant are also disclosed.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: October 9, 2018
    Assignee: HYDRITE CHEMICAL CO.
    Inventors: Dean Blankenburg, Eric M. Johnson, Charles A. Krier
  • Patent number: 10093590
    Abstract: The present disclosure provides a method for treating a solid fertilizer. The method comprises contacting the solid fertilizer with an amount of a liquid composition effective for reducing clumping in the fertilizer caused by absorption of water. The liquid composition may comprise one or more organic solvents and/or petroleum distillates. The organic solvents may be selected from the group consisting of glycol, dialkylcarbonate, C1-C4 alcohol, vegetable oil, esters of hydroxyacids, heterocyclic alcohols, cyclic esters of carbonic acid, and esters of dicarboxyacids.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: October 9, 2018
    Assignee: AgXplore International, LLC
    Inventor: Paul Hayes
  • Patent number: 10093591
    Abstract: A method of characterizing the structure of a void sensitized liquid energetic material, which method comprises defining the material in terms distribution function, the distribution function representing the fraction of liquid energetic material that occurs at a given point within the void sensitized liquid energetic material.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: October 9, 2018
    Assignee: Orica International Pte Ltd
    Inventors: John Cooper, Ian John Kirby, Vladimir Sujansky, Sek K Chan
  • Patent number: 10093592
    Abstract: A combustible element includes regions of fuel material interspersed with regions of oxidizer material. The element may be made by additive manufacturing processes, such as three-dimensional printing, with the fuel material regions and the oxidizer material regions placed in appropriate locations in layer of the combustible element. For example, different extruders may be used to extrude and deposit portions of a fuel filament and an oxidizer filament at different locations in each layer of the combustible element. The combustible element may define a combustion chamber within the element, where combustion occurs when the combustible element is ignited. The fuel material and the oxidizer material may be selected, and their relative amounts may be controlled, such that desired relative amounts of fuel and oxidizer are present for combustion with desired characteristics, such as combustion rate.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: October 9, 2018
    Assignee: Raytheon Company
    Inventors: Jeremy C. Danforth, Mark T. Langhenry, Matt H. Summers, Teresa Perdue
  • Patent number: 10093593
    Abstract: A process is presented for generating light olefins with the methanol to olefins process from a combination of catalysts. The process controls the product distribution for ethylene, propylene and butylenes, to enable shifting of the product distribution. The process includes passing a second catalyst to a reactor while the process is on-going.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: October 9, 2018
    Assignee: UOP LLC
    Inventors: Gregory A. Funk, Andrea G. Bozzano, Nicholas J. Schoenfeldt, Thulasidas Chellppannair, Wolfgang A. Spieker, Bipin V. Vora
  • Patent number: 10093594
    Abstract: An isoalkane alkylate base oil and a process to make an isoalkane alkylate base oil having a VI higher than 90, comprising: a. selecting an isoalkane feed containing at least one isoalkane and an olefin feed containing at least one linear olefin such that a combined carbon number of the isoalkane feed and the olefin feed is from 20 to 60; and b. alkylating the isoalkane feed with the olefin feed in the presence of an acidic alkylation catalyst under alkylation conditions to make the isoalkane alkylate base oil having the VI higher than 90; wherein the isoalkane alkylate base oil has a kinematic viscosity at 100° C. from 2 to 30 mm2/s, a pour point less than 0° C., and a bromine index less than 2000 mg Br/100 g.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: October 9, 2018
    Assignee: Chevron U.S.A. Inc.
    Inventor: Sven Ivar Hommeltoft
  • Patent number: 10093595
    Abstract: A process of catalytically dehydrogenating an alkane to an alkene, using Cr2O3 as a catalyst, where the catalyst is reduced concurrently with the dehydrogenation by using CO as a reducing gas. In reducing the catalyst with CO, CO2 is produced, which may be reacted with H2 produced by the dehydrogenation, to form CO and H2O by the reverse water-gas shift reaction. A Cu O heat-releasing material may be included with the catalyst in the reactor. The CO reducing gas reduces CuO to form Cu and CO2, releasing heat. The CO2 produced by reducing the Cu O may also be reacted with H2 produced by the dehydrogenation, to form CO and H2O by the reverse water-gas shift reaction.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: October 9, 2018
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: YongMan Choi, Ramsey Bunama, Khalid M. El-Yahyaoui
  • Patent number: 10093596
    Abstract: The present invention is, in a first embodiment, a process for removing oxygenated contaminants from an ethylene stream comprising: a) providing a dried ethylene stream (A) comprising essentially ethylene, up to 1 w % oxygenates, ethane, CO, CO2, H2, CH4 and C3+ hydrocarbons, b) sending said stream (A) to a stripper (also referred to as a demethanizer) to produce an overhead stream comprising essentially CO, H2 and CH4, a bottom stream comprising essentially ethylene, oxygenates, ethane, CO2 and C3+ hydrocarbons, c) sending said bottom stream of step b) to a deethanizer to produce a bottom stream comprising essentially ethane, oxygenates and C3+ hydrocarbons, an overhead stream consisting essentially of ethylene and CO2, d) sending said overhead of step c) to a fixed bed CO2 adsorption zone to recover an ethylene stream essentially free of CO2. In another embodiment the CO2 adsorption zone can be located at the inlet of the deethanizer. In another embodiment the demethanizer is replaced by two demethanizers.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: October 9, 2018
    Assignees: Total Research & Technology Feluy, IFP Energies Nouvelles
    Inventors: Babua Das, Manuela Arratia, Catherine Boutrot
  • Patent number: 10093597
    Abstract: In a process for separating one or more 3,3?-, 3,4?- and 4,4?-dimethyl biphenyl isomers, a feed comprising the isomers is contacted with an adsorbent containing a zeolite having a largest diffuse along dimension of at least 4 Angstroms. The adsorbents provide selective adsorption of 4,4?-dimethyl biphenyl.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 9, 2018
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Changyub Paek, Michael P. Lanci, Randall D. Partridge, Allen W. Burton, Peter I. Ravikovitch, Sumathy Raman
  • Patent number: 10093598
    Abstract: A process is described for separating paraxylene from a multicomponent fluid mixture of C8 aromatics. A mixture of C8 aromatics is fed to a simulated moving-bed adsorptive apparatus. The location of the feed to the apparatus is moved at set intervals. The rate of flow of feed to the apparatus is varied during each interval to enhance the separation of paraxylene from the multicomponent mixture.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: October 9, 2018
    Assignees: EXXONMOBIL CHEMICAL PATENTS INC., GEORGIA TECH RESEARCH CORPORATION
    Inventors: John D. Ou, Jeevan S. Abichandani, Yoshiaki Kawajiri, Siwei Guo
  • Patent number: 10093599
    Abstract: The present invention is a method for producing a fluorinated hydrocarbon represented by a structural formula (3), wherein an ether compound represented by a structural formula (1) and an acid fluoride represented by a structural formula (2) are brought into contact with each other in a hydrocarbon-based solvent, in the presence of a catalyst in which boron trifluoride is supported on a metal oxide: wherein R1 and R2 represent an alkyl group having 1 to 3 carbon atoms, R3 represents a hydrogen atom, a methyl group or an ethyl group, and R4 and R5 represent a methyl group or an ethyl group; and R1 and R2 may be bonded to each other to form a cyclic structure. Through the present invention, a method for industrially advantageously producing 2-fluorobutane is provided.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: October 9, 2018
    Assignee: ZEON CORPORATION
    Inventor: Tatsuya Sugimoto
  • Patent number: 10093600
    Abstract: A method to efficiently and stably produce trifluoroethylene from 1,1,1,2-tetrafluoroethane is provided. In the method, a material gas containing 1,1,1,2-tetrafluoroethane in a gaseous phase and calcium oxide in a solid phase are brought into contact with each other in a reactor. Clogging of the reactor is less likely to occur, the load of the moisture removal process is light, and problems such as a decrease in the yield of trifluoroethylene do not arise.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: October 9, 2018
    Assignee: AGC Inc.
    Inventors: Masahiko Nakamura, Hidekazu Okamoto
  • Patent number: 10093601
    Abstract: Compounds with fire extinguishing properties having the formula: wherein R1 is —CR5R6R7 or —CR5R6CR8R9R10 as well as fire extinguishing units including one or more of the compounds.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: October 9, 2018
    Assignee: The Boeing Company
    Inventors: Kimberly-Alice D. Gregersen, James Craig Moreland, Ekaterina A. Badaeva, Andrew M. Zweig
  • Patent number: 10093602
    Abstract: The invention provides a process for the catalytic conversion of a saccharide-containing feedstock in a reactor, wherein saccharide-containing feedstock is provided to the reactor as a feed stream through a feed pipe and is contacted with a catalyst system in the reactor and wherein, as the saccharide-containing feedstock is fed through the feed pipe, a solvent stream, initially comprising essentially no saccharide, is fed along the internal walls of the feed pipe.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 9, 2018
    Assignee: SHELL OIL COMPANY
    Inventors: Evert Van Der Heide, Pieter Huizenga
  • Patent number: 10093603
    Abstract: The present disclosure relates to an apparatus for generating glycol and a method thereof. More particularly, the present disclosure relates to an apparatus for generating glycol including (a) an aldol reactor; (b) an extractor for extracting an aldol product, unsaturated aldehyde, using an organic solvent that is not mixed with water; (c) a distillation column for removing a raw material from a solution extract that is discharged from the extractor; (d) a hydrogenation reactor for hydrogenating a solution extract that is discharged from the distillation column; and (e) a divided-wall distillation column for isolating glycol from a hydrogenated solution product that is discharged from the hydrogenation reactor, wherein the hydrogenation reactor is a fixed-bed catalytic reactor that is filled with a copper-based catalyst, and a method of preparing the same.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: October 9, 2018
    Assignee: LG Chem, Ltd.
    Inventors: Sung Shik Eom, Da Won Jung, Tae Yun Kim, Jung Uk Choi, Dong Hyun Ko, Mi Young Kim, Min Ji Choi
  • Patent number: 10093604
    Abstract: Novel heterocyclic selenabisphosphites, process for preparation thereof and use thereof as ligand unit for preparing ligands for use in complexes.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: October 9, 2018
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Katrin Marie Dyballa, Robert Franke, Claudia Weilbeer, Detlef Selent, Armin Börner
  • Patent number: 10093605
    Abstract: The present invention provides a novel process for producing 2,6,6-trimethyl-2-cyclohexene-1,4-dione (keto-isophorone) by catalytic oxidation of 3,5,5-trimethylcyclohexa-3-ene-1-one (?-isophorone) with hydrogen peroxide as the oxidant. In particular, the novel process includes phase transfer reagent in a biphasic system including an organic phase and an aqueous phase wherein the biphasic system includes 1) a tungsten polyoxyometallate as catalyst and hydrogen peroxide, and/or 2) a mixture of a) a mineral acid, b) hydrogen peroxide, and c) a metal tungstate.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: October 9, 2018
    Assignee: Evonik Degussa GmbH
    Inventors: Stephanie Bajus, Jan Caßens, Jens Döring, Jörg-Joachim Nitz, Stephan Kohlstruk, Robert Jansen
  • Patent number: 10093606
    Abstract: The present invention relates to a process for preparing farnesyl acetone.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: October 9, 2018
    Assignee: BASF SE (REITSTÖTTER, KINZEBACH & PARTNER)
    Inventors: Mathias Schelwies, Rocco Paciello, Heinz Eckhardt, Martine Dehn
  • Patent number: 10093607
    Abstract: The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R?, wherein R? is —(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR?, wherein X is an alkali metal, and R? is defined as above.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: October 9, 2018
    Assignee: BASF SE
    Inventors: Eric George Klauber, Michael Rack, Thomas Zierke, Nicole Holub, David Cortes, Gerald Schmelebeck, Junmin Ji
  • Patent number: 10093608
    Abstract: The invention pertains to a method for preparing succinic acid which comprises providing an aqueous magnesium succinate solution to an acidification step, wherein the magnesium succinate solution is acidified by the addition of hydrogen chloride, thereby obtaining an aqueous solution comprising succinic acid and magnesium chloride and subjecting the aqueous solution comprising succinic acid and magnesium chloride derived from the acidification step to a treatment step with active carbon followed by precipitating succinic acid from an aqueous mixture comprising succinic acid and magnesium chloride resulting from the active carbon treatment step in a precipitation step to form solid succinic acid. It has been found that the method according to the invention leads to succinic acid crystals with better properties than a comparable method wherein no active carbon treatment is used.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 9, 2018
    Assignee: PURAC BIOCHEM B.V.
    Inventors: Jan Van Breugel, Peter Paul Jansen, Jose Maria Vidal Lancis, Tanja Dekic Zivkovic, Adriaan Dirk Kon
  • Patent number: 10093609
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: October 9, 2018
    Assignee: Emory University
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • Patent number: 10093610
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 9, 2018
    Assignee: DIPHARMA S.A.
    Inventor: Emanuele Attolino
  • Patent number: 10093611
    Abstract: The present invention relates to fungicidal benzocycloalkene carboxamides or their thiocarboxamide derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: October 9, 2018
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Ulrike Wachendorff-Neumann
  • Patent number: 10093612
    Abstract: The present invention relates to a process to prepare N,N?-di(2-hydroxybenzyl) ethylenediamine-N,N?-diacetic acid and salts thereof comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof and phenol at a pH of between 3 and 7 and a temperature below 60° C. wherein the reaction mixture contains 0.2 to 1.1 molar equivalents of alkali metalions on the molar amount of EDDA.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 9, 2018
    Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Adrianus Maria Reichwein, Hubertus Johannes Jongen, Marjolein Groote
  • Patent number: 10093613
    Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: October 9, 2018
    Assignees: GTX, INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Charles B. Duke, Christopher C. Coss, Amanda Jones, James T. Dalton
  • Patent number: 10093614
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: October 9, 2018
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Eric Anderson, Xin Jiang, Melean Visnick
  • Patent number: 10093615
    Abstract: The invention relates to a process for preparing isocyanates by reacting primary amines with phosgene in a solvent, where the solvent comprises a dialkyl carbonate.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: October 9, 2018
    Assignee: BASF SE
    Inventors: Manfred Heilig, Thomas Schulz, Torsten Mattke, Filip Nevejans, Kai Thiele, Stefan Maixner
  • Patent number: 10093616
    Abstract: Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 9, 2018
    Assignee: THERACOS SUB, LLC
    Inventors: Jacques Roberge, Carine Vaxelaire, Baohu Liu, Ge Xu, Jian Zhang, Xinxing Tang, Baihua Xu
  • Patent number: 10093617
    Abstract: A compound represented by formula (3): (wherein R1 represents a C1-C6 alkyl group optionally having one or more halogen atoms, R2 represents a C1-C6 alkyl group, and m represents an integer of 0 to 3) can be produced by reacting a C1-C6 alkanesulfinic acid salt optionally having one or more halogen atoms with a compound represented by formula (2): (wherein R2 and m are as defined above) in the presence of a protonic acid.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 9, 2018
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Junichi Ishikawa, Yuta Honda
  • Patent number: 10093618
    Abstract: The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acceptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: October 9, 2018
    Assignee: Avexxin AS
    Inventors: Marcel Sanderberg, Inger-Reidun Aukrust
  • Patent number: 10093619
    Abstract: A method of producing an organopolysulfide or salt thereof is provided which includes a step of mixing an organomonosulfide or salt thereof and elemental sulfur, wherein the mixing is carried out at a temperature not greater than 95 C and in the absence of any added liquid phase for a time effective to produce the organopolysulfide or salt thereof. The described method makes possible the preparation of organopolysulfides and organopolysulfide salts without the use of solvent or catalyst.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 9, 2018
    Assignee: Arkema Inc.
    Inventors: George C. Fortman, Gary S. Smith
  • Patent number: 10093620
    Abstract: Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 9, 2018
    Assignee: PELLFICURE PHARMACEUTICALS, INC.
    Inventors: Per Borgström, Adrian Chrastina, Veronique Therese Baron, Parisa Abedinpour
  • Patent number: 10093621
    Abstract: The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein: X is —COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO— wherein R2 is straight or branched C1-C10 alkyl, for use as antitumoral agents.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: October 9, 2018
    Assignee: FONDAZIONE IRCCS INSTITUTO NAZIONALE DEI TUMORI
    Inventors: Maria Grazia Daidone, Valentina Appierto, Paola Tiberio, Sabrina Dallavalle, Loana Musso, Elisa Niccolini
  • Patent number: 10093622
    Abstract: Disclosed herein is an efficient, economical, industrially advantageous, straight-through process for the preparation of cyclic amides, also referred as lactams, in substantially pure form and high yield, from the corresponding cyclic ketones and a hydroxylammonium salt, using a combination of amphoteric metal oxide or amphoteric masked metal oxide and a base.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 9, 2018
    Assignee: ANTHEA AROMATICS PRIVATE LIMITED
    Inventors: Manoj Kumar Mohapatra, Ramamohanrao Bendapudi, Paul Vincent Menacherry, Vincent Paul
  • Patent number: 10093623
    Abstract: Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 9, 2018
    Assignee: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • Patent number: 10093624
    Abstract: Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 9, 2018
    Assignee: AbbVie Inc.
    Inventors: Rick F. Clark, Michael L. Curtain, Todd M. Hansen, Howard R. Heyman, Helmut Mack, Michael Michaelides, Marina A. Pliushchev, Omar J. Shah, Bryan K. Sorensen, Ramzi Sweis, Chris Tse, Anil Vasudevan, Kevin R. Woller