Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.

Abstract: The invention described herein provides novel ampiphilic compounds that self-assemble into a hydrogel composition useful for treating wounds, including chronic wounds and diabetic wounds. The compounds of the invention have structural characteristics, such as hydrophilic and hydrophobic moieties, that enable self-assembly into discrete nanostructures, which then entangle to form the hydrogel. Also provided are methods for treating wounds.

Abstract: The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.

Abstract: The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.

Abstract: Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

Abstract: Provided are a micelle composition for nucleic acid delivery using a temperature-sensitive polymer, and a method for producing the micelle. For example, provided is a polyion complex comprising a temperature-sensitive copolymer and a nucleic acid, wherein the temperature-sensitive copolymer comprises a cationic block and a temperature-sensitive block, the cationic block optionally carrying a hydrophilic block linked thereto, and the polyion complex is obtained by mixing the temperature-sensitive copolymer with the nucleic acid under temperature conditions equal to or lower than the lower critical solution temperature (LCST) of the temperature-sensitive copolymer.

Abstract: The present disclosure provides compositions comprising a complex comprising octadecylamine surface-functionalized nanodiamonds with dexamethasone bound to octadecylamine. In another aspect the invention comprises a method for reducing inflammation in a patient comprising locally administering a composition comprising a complex comprising octadecylamine surface-functionalized nanodiamonds with dexamethasone bound to octadecylamine. In a further aspect, the invention comprises a method for reducing inflammation in a patient comprising locally administering a composition comprising octadecylamine surface-functionalized nanodiamonds, wherein no therapeutic agent is bound to the nanodiamonds.

Abstract: A nanoparticle that has a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, a targeting group attached to the outside of the nanoparticle, and a breast cancer therapeutic agent that is encapsulated by the membrane. A nanoparticle that consists of a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, breast cancer therapeutic agent that is encapsulated by the membrane, and an anti-Her2 antibody attached to the outer surface of the nanoparticle. A range of a number average molecular weight of the PEG block is 800 Da to 3 kDa and a range of a number average molecular weight of each of the PLA blocks is from 1 kDa to 5 kDa.

Abstract: The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

Abstract: A method to prevent, inhibit or treat one or more symptoms associated with disease of the central nervous system by intranasally, intrathecally, intracerebrovascularly or intravenously administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease, in an amount effective, e.g., to provide for cross-correction.

Abstract: To provide method for evaluating hematotoxicity of drug to be evaluated, which is excellent in clinical predictability regarding toxicity to the bone marrow, and model for evaluating hematotoxicity of drug to be evaluated. The method for evaluating the hematotoxicity of the drug to be evaluated, the method including: administering the drug to be evaluated to humanized, transgenic NOG mouse, which is obtained by introducing human GM-CSF/IL-3 gene into NOG mouse and the number of human-derived leucocytes in leucocytes in blood thereof is 20% or more; and evaluating that the drug to be evaluated has the hematotoxicity when sample of the humanized, transgenic NOG mouse after the administering the drug to be evaluated is measured for number of cells of human-derived hemocytes, the number of the cells of the human-derived hemocytes is changed compared to control to which vehicle is administered instead of the drug to be evaluated.

Abstract: The disclosure provides methods of generating a murine model of neonatal necrotizing enterocolitis, whereby the generated murine animal exhibits at least one symptom of neonatal necrotizing enterocolitis. The disclosure also provides methods to measure transfusion effects on anemia and methods for identifying and isolating an agent useful for the treatment or prevention of neonatal necrotizing enterocolitis.

Abstract: The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins.

Abstract: The invention relates to a ligand compound having a structure A-B-C, wherein (a) A represents a mono- or polyphosphorylated amino acid linked to part B by its amino group to form an amide bond; B represents (i) a carboxylic acid, and (ii) an amino acid or peptidyl group of 2-10 amino acids, an alkyl or alkenyl group comprising 1-26 carbon atoms, a polyethylene glycol group comprising 1-26 carbon atoms or a combination thereof covalently linked to the carboxylic acid; and C represents a hydrophilic group covalently linked to the group of B (ii) or (b) A represents a mono-or polyphosphorylated amino acid linked to B by its carboxylic acid to form an amide bond; B represents an amino acid or peptidyl group of 2-10 amino acids, an amino substituted alkyl or alkenyl group comprising 1-26 carbon atoms, an amino substituted polyethylene glycol group comprising 1-26 carbon atoms or a combination thereof covalently linked to A by their amino group; C represents a hydrophilic group covalently linked to the group of B.

Abstract: The present invention provides reagents and methods for detecting cancer and precancerous lesions in a patient.

Abstract: The present invention relates to a preheated sterilizing box for medical laboratory equipment, comprising a body, a cover hinged to the body through a hinge, and an attachment device for preventing collision between preheated equipment. The cover comprises a cover housing, a UV lamp disposed on the cover and a transparent cover board. The body is separated by the separator and the heat guiding plate into a first chamber for holding preheated sterilizing equipment, a second chamber disposed with temperature control circuitry, a third chamber disposed with a heating material and a fourth chamber disposed with a battery. An insulating layer is disposed on the inside wall of the first chamber and the third chamber, a temperature sensor is embedded in the insulating layer disposed on the inside wall of the first chamber. A number of heat guiding poles and through holes are disposed on the heat guiding plate. The attachment device is disposed on the through holes.

Abstract: Systems and methods are described for rapid sterilization of items in a vacuum or sterilization chamber. Embodiments include conductively heated, vacuum-based sterilization approaches that can be applied to devices, such as medical devices, electronic devices, and other suitable devices. For example, an item that has been exposed to excessive contamination is placed inside the sterilization chamber. The chamber can be depressurized to a vacuum level sufficient to gasify liquids inside a solid matrix holding a liquid sterilant, and the item can be conductively heated at least to replace latent heat of vaporization lost during the depressurization. Some embodiments include techniques relating to quality processing, monitoring and feedback control, and/or other functionality.

Abstract: A curtain sanitizer device and method, such as for use in the healthcare industry, is disclosed that can sanitize at least a portion of the surface of a hung curtain, e.g. a privacy curtain, by directing UV-C light thereat to kill or inactivate harmful microorganisms thereon that can cause infectious disease, thereby reducing the risk of spreading infectious disease. In one example, at least a portion of opposite surfaces or sides of the hung curtain can be simultaneously sanitized. The curtain sanitizer device and method can allow the curtain to be cleaned in place, and can be easier to use and less costly and time consuming than other currently available methods and devices.

Abstract: An odor reducing composition comprising a scent and silver nanoparticles is disclosed, together with methods of making and using the same, and methods for reducing an odor.

Abstract: An assembly for evaporating a volatile fluid is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough at a frequency of between substantially 20 KHz to substantially 500 KHz and a volatile fluid transport means receiving area containing at least one piece of heat-conducting, non-magnetic metal foil and/or deposited heat-conducting, non-magnetic metal; and wherein the refill comprises a reservoir for the volatile fluid, a volatile fluid transport means to draw the fluid from the reservoir, and at least one magnetic susceptor having a coercivity of substantially 50 ampere/metre (Hc) to substantially 1500 ampere/metre (Hc).

Abstract: A volatile composition dispenser is configured to be used in a vehicle. The volatile composition dispenser comprises a housing and a fan positioned at least partially within the housing. The fan is configured to intermittently activate to move a volume of air. The volatile composition dispenser further comprises a controller in electrical communication with the fan and positioned within the housing, and a replaceable unit configured to be attached to the housing and positioned at least partially within the housing.

Abstract: An absorbent article comprising a topsheet, an outer cover, at least one chassis component, and an absorbent core disposed between the topsheet and the outer cover, wherein at least one of the outer cover or chassis component comprises a dual bilaminate comprising two bilaminates combined, wherein each bilaminate comprises at least one nonwoven layer and at least one multilayer film, and wherein the dual bilaminate has at most about 90 grams per square meter basis weight.

Abstract: A wound dressing having anti-microbial activity comprises a first fibre capable of bonding with silver (1) cations. The wound dressing comprises a blend of the first fibre to which silver (1) cations are bonded and a second fibre which is substantially free from silver. The wound dressing comprises from 0.01 to 5.0 percent by weight of silver (1) cations, based on the weight of fibre.

Abstract: Improved skin-adhesive compositions for bonding a substrate, such as an absorbent article, to skin are disclosed. More particularly, the skin-adhesive composition has an improved, yet gentle, adhesion to the skin of a user, while maintaining strong, effective bonding to various inanimate, non-skin substrates. In one embodiment, the skin-adhesive composition can provide one or more skin benefit agents to the user. The skin-adhesive composition may be applied to an absorbent article, such as a panty-liner, sanitary napkin, or an incontinence article, for directly adhering the article to the skin of a user.

Abstract: A fiber-SAP particle includes a superabsorbent core particle (SAP core particle) and a plurality of fibers attached to the SAP core particle and extending therefrom. The fiber-SAP particles may be formed in a fluidized bed chamber using a spray drying process. The fiber-SAP particles may be incorporated into absorbent cores and articles, such as in disposable diapers.

Abstract: A membrane having at least one strip of a shape memory material and the at least one strip is sandwiched between a first layer and a second layer. A method for guiding bone regeneration which excludes the use of a tenting screw is also disclosed. The membrane may be useful for gradual displacing of the soft tissue covering bones. The gap developing between the bone and the displaced soft tissue may be filled with regenerated bone. The membrane allows the regenerated bone to form while the soft tissue heals. The membrane and method may be useful in dentistry for treating vertical bone defects. The membrane and method may also be useful for regenerating soft tissue between the bone and the displaced soft tissue.

Abstract: Described herein are preparations and applications of gellan gum hydrogel for cell culture and biomedical applications, including 2D coating culture, 3D cell culture, and injection. The gellan gum materials for such application include water soluble low acyl gellan gum, high acyl gellan gum, modified gellan gum and a mixture of gellan gum mixture with other chemical/biological molecules.

Abstract: A composite collagen hydrogel material for use in tissue engineering, and an implantable ophthalmic device comprising such composite material. The composite material comprises: a first collagen network comprising collagen crosslinked with a first crosslinking agent, and/or a second collagen network comprising collagen crosslinked with a second crosslinking agent, and a three dimensional collagen mesh comprising partially and plastically compressed collagen hydrogel with a compression degree of 50-95%, wherein the three dimensional collagen mesh is embedded in the first collagen network and/or second collagen network, and the first collagen network and/or the second collagen network and the three dimensional collagen mesh are physically and chemically interconnected in the composite collagen hydrogel material.

Abstract: Bifunctional coatings and implants coated with the same are described, as well as methods and compositions for making the same.

Abstract: The present invention relates to the field of treatment of bone defects. The invention provides a composition for treatment of bone defects as well as methods for treatment of such defects.

Abstract: Provided herein are soluble soft tissue protein compositions that can contain one or more soft-tissue bioactive factors, methods of making the soluble soft tissue protein compositions, and methods of using the soluble soft tissue protein compositions.

Abstract: Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof Also provided are kits that include the present bone grafts and/or constructs, or components thereof.

Abstract: A composite material for bone repair based on a decellularized biological tissue matrix material and a preparation method thereof. The composite material for bone repair comprises an organic phase of a microfibrillar decellularized animal tissue matrix material and an inorganic phase of a calcium salt bioceramic or other inorganic bioglass. A preparation process for the composite material for bone repair does not need physical or chemical crosslinking. The composite material for bone repair has a three-dimensional porous network structure, and protein components in the biological tissue matrix material maintain a natural triplex structure. The composite material for bone repair has excellent biocompatibility, biodegradability, osteoconductivity, osteoinductivity, and osteogenecity, also has certain mechanical strength and shape memory function, and can be used as a bone filling material or a repair material for large-area bone defect.

Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.

Abstract: Provided is a medical base material that is suitable for regeneration of a cardiovascular system being exposed to high pressure from a lumen, such as an aorta and is absorbed by a living body after transplantation. The medical base material of the present invention has a sheet shape, a tube shape, or a combined shape thereof and is used for regeneration of a cardiovascular system by being transplanted in a body. The medical base material has a multilayer structure at least including an inner layer to be arranged on the intimal side of the cardiovascular system and an outer layer to be arranged on the adventitial side of the cardiovascular system from the inner layer and made from a material at least including a stereo complex polylactic acid. The layer to be arranged on the adventitial side of the cardiovascular system from the inner layer is formed in a porous form such that a nutrient blood vessel reaches the inner layer or enters the vicinity of the inner layer.

Abstract: The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells (Human mesenchymal stem cells, Human fibroblast, Keratinocytes, fibroblast differentiated form mesenchymal stem cells in vitro and keratinocytes differentiated form mesenchymal stem cells in vitro) in vitro for continued periods of time. In the present invention, mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord are inoculated and grown on a pre-established scaffold or matrix made up of chitosan and gelatin. The developed tissue constructs contain cells, growth factors, cytokines and other regulatory factors secreted by cells. The developed bioengineered tissue constructs provide the support, growth factors and essential cytokines for wound healing. Developed tissue construct useful in the treatment of burns wound, diabetic foot ulcer wound and type of chronic skin wounds. It is helpful in healing and regeneration of skin tissue.

Abstract: The present invention relates to a nanoparticle, a preparation method thereof, a stone removing device and its application. The nanoparticle includes a nanoparticle core made of a magnetic material, and a nanoparticle shell formed by attaching a surface modifier monomer to the nanoparticle core with an initiator and/or a crosslinking agent. The prepared nanoparticle can surround stones in ureter, and then small stone remaining in body can be removed quickly without damage from the body under the action of an externally applied magnetic field, that is, the stone can be drawn and moved without injuring ureteral wall, and meanwhile the nanoparticles are placed conveniently without shift.

Abstract: Devices prepared from polyetherimide resins are disclosed. In one aspect, the article can be a medical device configured for use in a body.

Abstract: An aspiration device is described, including a bulb aspirator including a bulb body, a first collar and tip, the bulb body includes an upper portion configured for receiving one end of the first collar and lower portion configured for receiving in a first configuration a stop and in a second different configuration a second collar associated with a suction tube, the tip is configured for insertion into a passageway; the stop being configured for detachable connection to the lower portion of the bulb body when in the first configuration; and the suction tube including the second collar, a tube portion and an adaptor, the second collar is disposed at a first end of the suction tube and being adapted to be coupled to the lower portion of the bulb body, the adaptor is configured to adapt to a human mouth to enable suction to be applied at the adaptor.

Abstract: A device for helping maintain a mouth of a patient in an open position during a dental procedure may include a novel suction device that preferentially aspirates fluids and not the tissues of the mouth.

Abstract: In one example embodiment, a vibration apparatus can augment and enhance negative-pressure therapy systems. The apparatus can be attached to an external surface of a dressing, fluid conductor, or other components. The apparatus can generate low-amplitude vibrations, which can be transmitted through the components. Kinetic energy of the oscillations can agitate fluid in the components, which can lower the viscosity of the fluid and reduce the frequency of blockages in fluid conductors. Vibrations may also agitate a tissue site, which can encourage blood flow and granulation.

Abstract: A vacuum overdressing sealing a wound. The dressing has a layer of overdressing that is generally rectangular with a top side and a bottom side and two longer ends and two shorter ends. The overdressing layer has a port through which a vacuum can be pulled when the wound is sealed by the dressing. The port is located near one of the ends of the dressing.

Abstract: A dressing for treating a tissue site may include a base layer, a sealing member, a first and a second wicking layer, and an absorbent layer. The base layer may have a periphery surrounding a central portion and a plurality of apertures disposed through the periphery and the central portion. The apertures in the periphery may be larger than the apertures in the central portion. The sealing member and the base layer may define an enclosure. The first and the second wicking layer may each be disposed in the enclosure with the absorbent layer positioned between the first and the second wicking layer. Other dressings, systems, and methods are disclosed.

Abstract: Provided are methods for preparing pathogen-inactivated platelet compositions, as well as processing sets and compositions related thereto.

Abstract: The photo therapy apparatus of the present invention comprises one or more light sources which are integrated with a breast pump for providing photo therapy treatment to the breast and nipple of women during pumping of breast milk. The light sources can be lasers, light emitting diodes (LEDs), lamps, or any other types of light sources which produce therapeutic light in a desired wavelength range. The therapeutic light is delivered through the breast-shield or flange of the breast pump to the breast and nipple and produces a variety of photochemical processes, e.g. increase of ATP (adenosine triphosphate), triggering of photo neurological response and activation of enzymes, changes in local pressure, increases in temperature, and deformation of cellular membranes. Such photochemical reaction helps to reduce pain and promote healing of nipple lesion and in the meantime enhance yield of breast milk.

Abstract: A pump apparatus and method for extracting breast milk is disclosed. The pump includes a first interface component to stimulate a Milk Ejection Reflex (MER) and a second interface component to extract breast milk. Milk is extracted through an improved method that more closely replicates the suckling of an infant.

Abstract: A cutting edge of a punch includes side segments and a central segment disposed between the side segments. When the punch head slides into a hollow blade, the central segment of the cutting edge meets the punch head before the side segments meet the punch head. The central segment starts cutting first, which can help avoid a dog-bone shaped hole when the punch is used on a blood vessel, such as the aorta.

Abstract: The application relates to an external drive unit (7) for an implantable heart assist pump. The proposed drive unit (7) comprises a motor (35) for driving the heart assist pump, wherein the motor (35) is connectable to the heart assist pump via a transcutaneous drive shaft (3). The drive unit (7) further comprises a heat spreader (19) comprising a contact surface configured to contact and/or directly contact and/or lie flat against a skin of a patient. The contact surface is connected or connectable with the motor (35) in a thermally-conductive manner to transfer heat generated by the motor (35) to tissue of the patient.

Abstract: A heart pump arrangement including a heart pump and a control apparatus connected thereto, where the control apparatus has a first connector element of a first connection device, and including an intermediate plug-in module, which has a second connector element, which is detachably connectable to the first connector element, wherein the intermediate plug-in module has a second connection device, which is non-detachable or which is detachable within a framework of a second connection, for connection to an electrical power source, and additionally a third connection device, which is non-detachable or which is detachable within a framework of a third connection, for connection to a data processing device, in particular a terminal. By means of the connection possibilities of the intermediate plug-in module on the secondary side, incorrect connections to connected batteries, power supply units, or other apparatuses to be connected are minimised.