Patents Issued in October 11, 2018
  • Publication number: 20180290929
    Abstract: A coating system disposed on a surface of a substrate is provided. The coating system may include a bond coating layer on the surface of the substrate, a dense TBC layer on the bond coating layer, and a columnar TBC layer on the dense TBC layer, with the columnar TBC layer defines a plurality of elongated surface-connected voids. The dense TBC layer generally includes a ceramic material and has a porosity of about 15% or less. A method is also provided for forming a coating system on a surface of a substrate.
    Type: Application
    Filed: April 7, 2017
    Publication date: October 11, 2018
    Inventors: Michael David Clark, Douglas Gerard Konitzer
  • Publication number: 20180290930
    Abstract: A generally spherical high strength ceramic body for use in an ATR and/or SR unit covering a catalyst media bed. The ceramic body is a fully stabilized YSZ composite composition having at least about 13% yttria YSZ, and more typically from about 12% to about 20% yttria YSZ, with a porosity of less than 20 percent and a diameter of at least 25 mm and, more typically, selected from the group comprising 25 mm, 50 mm, 76 mm and 100 mm.
    Type: Application
    Filed: September 6, 2017
    Publication date: October 11, 2018
    Inventor: Brian K. Osborne
  • Publication number: 20180290931
    Abstract: A corrosion resistant refractory ceramic hexagonal target tile body for use covering a catalyst, including a generally flat hexagonal portion and a plurality of generally right circular cylindrical aperture portions extending therethrough, wherein the hexagonal tile body has a thickness of about 89 mm and a width of about 42 cm and is 13 percent yttria fully stabilized YSZ. Each respective aperture has a diameter of about 19 mm.
    Type: Application
    Filed: September 6, 2017
    Publication date: October 11, 2018
    Inventor: Brian K. Osborne
  • Publication number: 20180290932
    Abstract: Fused grains, in which the grains include a matrix of the zirconia-spinel eutectic coating inclusions composed essentially of a zirconia phase or of a spinel phase, the grains exhibit the following overall chemical composition, as percentages by weight expressed in the form of oxides: more than 45.0% and less than 95.0% of ZrO2, more than 3.0% and less than 40.0% of Al2O3, more than 1.0% and less than 20.0% of MgO, wherein ZrO2, Al2O3 and MgO together represent at least 95.0% of the weight of the grains.
    Type: Application
    Filed: October 19, 2016
    Publication date: October 11, 2018
    Inventors: Stéphane RAFFY, Nabil NAHAS
  • Publication number: 20180290933
    Abstract: A functionally graded carbide body (400) can include a group 5 metal carbide substrate having a bulk composition region (410) that contains at least 70 wt % of a rhombohedral ?-phase carbide. A ?-phase-rich region (420) having a ?-phase-rich composition can be at a surface (430) of the substrate, and a phase composition gradient region (440) can transition from the ?-phase-rich composition region at the surface to the bulk composition region at a gradient depth (450) below the surface.
    Type: Application
    Filed: January 22, 2016
    Publication date: October 11, 2018
    Inventors: Dinesh Shetty, Raymond Cutler, Michael M. Sygnatowicz
  • Publication number: 20180290934
    Abstract: A refractory metal matrix-ceramic compound multi-component composite material with the super-high melting point is disclosed. At least one ceramic compound A and at least one refractory bonding metal B are fused together by the smelting process to make the multi-component composite material. The fused ingredients of the multi-component composite material are mAnB, and 2?(m+n)?13. The positive integer m is the number of the kinds of the ceramic components A, and the positive integer n is the number of the kinds of the refractory bonding metals B. The absolute value of the combining enthalpy of the ceramic compound A is larger than the absolute value of the combining enthalpy between the ceramic compound A and the refractory bonding metal B. The material has the properties including over 3000° C. melting point, high stability, hardness, ductility, and fusibility in high or low temperature, fast production, and low cost.
    Type: Application
    Filed: May 2, 2018
    Publication date: October 11, 2018
    Inventor: Swe-Kai CHEN
  • Publication number: 20180290935
    Abstract: A long-term stabilized aqueous initiator composition, which includes components for curing of a two-component mortar system composition. The long-term stabilized aqueous initiator composition includes an activator component that has an alkali and/or alkaline earth metal salt, an accelerator component that has a water-soluble alkali and/or alkaline earth metal salt, a retarder selected from citric acid, tartaric acid, lactic acid, salicylic, gluconic acid, and a mixture of these components, a mineral filler selected from a limestone filler, corundum, dolomite, alkaline-resistant glass, crushed stone, gravel, pebble, and a mixture of these components, a thickening agent, and water.
    Type: Application
    Filed: October 19, 2016
    Publication date: October 11, 2018
    Applicant: HILTI AKTIENGESELLSCHAFT
    Inventors: Armin PFEIL, Pascal BEROLL
  • Publication number: 20180290936
    Abstract: The present invention relates to separation methods and systems for converting high concentrations of animal wastes into useful products, wherein the separation of the desired useful products is conducted with a cross-flow filtration system having the ability to the separate desired useful energy and/or products from both viscous and non-viscous medium.
    Type: Application
    Filed: May 17, 2018
    Publication date: October 11, 2018
    Inventors: Mark VANDER HOFF, Todd BENSON, Marc PUGH, Jason BELL
  • Publication number: 20180290937
    Abstract: The invention relates to a process for the production of urea ammonium nitrate, a system and a method of modifying a plant. The process comprises treating ammonia-containing off-gas resulting from the production of ammonium nitrate (AN off-gas) with acidic scrubbing liquid in a finishing treatment section having a gas inlet in fluid communication with a gas outlet of a finishing section of a urea production unit, wherein the finishing section is adapted to solidify urea liquid, and wherein said finishing treatment section is adapted to subject ammonia-containing off-gas of the finishing section to treatment with an acidic scrubbing liquid.
    Type: Application
    Filed: December 21, 2016
    Publication date: October 11, 2018
    Applicant: Stamicarbon B.V.
    Inventors: Giusy Elisa PUCI, Joey DOBREE
  • Publication number: 20180290938
    Abstract: Plant supplements that promote plant growth and production and aid in the protection of plants from environmental stress factors such as wind, heat, cold and drought are disclosed. The plant supplements comprise calcium, magnesium and plant-available silica, most typically in a single liquid non-coagulating solution. Optionally, the plant supplements may further comprise iron, nitrogen, willow tree bark extract, humic acid, fulvic acid, aloe vera, trace minerals, electrolytes, beneficial microbes and/or other non-plant food ingredients. Aspects of the present invention also provide methods of formulating and administering plant supplements for promoting plant growth and production, and for protecting plants from environmental stress factors.
    Type: Application
    Filed: April 7, 2017
    Publication date: October 11, 2018
    Inventor: Imran AKHUND
  • Publication number: 20180290939
    Abstract: The present invention provides a fertilizing device having a permeable package for fertilizer and a method for slowly releasing fertilizer by placing the fertilizing device in or onto the soil in the vicinity of the plants or the crops. The permeable package is enclosed with a layer for protecting the package and preventing unintended release of fertilizer from the permeable package.
    Type: Application
    Filed: February 29, 2016
    Publication date: October 11, 2018
    Inventor: KIM FUI NG
  • Publication number: 20180290940
    Abstract: A granular fertilizer product having at least two sources of boron having different solubilities to tailor boron availability during the entire growing season of a plant, while reducing the risk of boron toxicity. A first source of boron can include a sodium-based or highly water soluble boron compound such as sodium tetraborate and/or boric acid, while a second source of boron can include a calcium-based boron compound such as colemanite (CaB3O4(OH)3.(H2O)) (e.g. when the carrier fertilizer is N- or K-based) and/or boron phosphate (BPO4) (e.g. when the carrier fertilizer is P-based). The solubility of the first source of boron is higher than the solubility of the second source of boron such that the sources of boron have different release rates into the soil.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 11, 2018
    Inventors: Michael McLaughlin, Jozefien Degryse, Roslyn Baird, Rodrigo Coqui da Silva, Kyle Freeman, Thomas Fry
  • Publication number: 20180290941
    Abstract: The present invention utilizes a high-speed intensive mixer in fluidizing type solid phase neutralization reactor to blend solid state alkali hydroxide with any humic acid sources. The final product is a dry humic acid salt. The purpose of this innovative method is to eliminate a series of complicated unit operations commonly employed by the traditional process. These removed steps may include dissolving caustic soda, mixing in a paste like formation, extrusion, granulation, drying, and grinding, etc. The new invention contributes to a simplified flowsheet, resulting in sharply reduced equipment investment, the required plant space, and labor and energy costs. All these factors coupled with increased productivity will drastically lower the overall production cost. Also the reduction of dust pollution will greatly minimize the impact in environmental protection and safety issues.
    Type: Application
    Filed: April 10, 2017
    Publication date: October 11, 2018
    Inventor: JAMES CHIN CHENG YANG
  • Publication number: 20180290942
    Abstract: The invention relates to methods for promoting fixed nitrogen from atmospheric nitrogen, and related products. Endophytic bacteria having an exogenous nif cluster promote fixed nitrogen for cereal plants.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 11, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Christopher A. Voigt, Min-Hyung Ryu, Mi Ryoung Song
  • Publication number: 20180290943
    Abstract: The present invention relates to a method of enhancing growth conditions for plants by growing the plants in soil containing, in proximity to the plant roots, both a phosphorus source and at least two strains of the fungus Penicillium, particularly P. bilaiae, more particularly strains NRRL 50162 and NRRL 50169.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Applicant: NOVOZYMES BIOLOGICALS LIMITED
    Inventors: Garry Lawrence Hnatowich, Shelagh Jean Steckler, Mary Leggett, Kari Priest
  • Publication number: 20180290944
    Abstract: An Internet of Things (IoT) BIoTower™ for recycling food wastes into nutrients and for growing organic plants is disclosed which includes a food waste disposable tower for receiving food wastes; a multi-leveled carousels connected to the food waste disposable tower, each containing soils infested with earthworms; and an Internet of Things (IoT) irrigation system designed to provide sustainability to the soils and the organic plants.
    Type: Application
    Filed: April 9, 2017
    Publication date: October 11, 2018
    Inventor: THINH HOANG DO
  • Publication number: 20180290945
    Abstract: A high performance composite pyrotechnic product without lead in its composition, and that can be obtained on an industrial scale without encountering a problem of potlife for the intermediate paste, the product containing organic energetic charges and a combustion catalyst in a plasticized binder including a cured energetic polymer and at least one energetic plasticizer. In characteristic manner, the cured energetic polymer consists of a glycidyle azide polymer (GAP) having number average molecular weight (Mn) lying in the range 700 g/mol to 3000 g/mol, cured via its hydroxyl terminal functions with at least one curing agent of polyisocyanate type; and the combustion catalyst consists of bismuth citrate.
    Type: Application
    Filed: October 27, 2015
    Publication date: October 11, 2018
    Inventors: Fabienne MORIN, Martine GOLFIER, Caroline CARAYON
  • Publication number: 20180290946
    Abstract: Paraffin compositions including mainly even carbon number paraffins, and a method for manufacturing the same, is disclosed herein. In one embodiment, the method involves contacting naturally occurring fatty acid/glycerides with hydrogen in a slurry bubble column reactor containing bimetallic catalysts with equivalent particle diameters from about 10 to about 400 micron. The even carbon number compositions are particularly useful as phase change material.
    Type: Application
    Filed: May 7, 2018
    Publication date: October 11, 2018
    Inventors: Ramin Abhari, H. Lynn Tomlinson, Vladimir Gruver
  • Publication number: 20180290947
    Abstract: A method for producing a conjugated diene, including a step A of allowing an ?-olefin and formaldehyde to react with each other to produce a ?,?-unsaturated alcohol in the presence of an alcohol; and a step B of subjecting the ?,?-unsaturated alcohol to a dehydration reaction at 135 to 210° C. in the presence of an aqueous solution of an acidic catalyst.
    Type: Application
    Filed: June 1, 2016
    Publication date: October 11, 2018
    Applicant: KURARAY CO., LTD.
    Inventors: Yutaka SUZUKI, Masaki SHIMIZU
  • Publication number: 20180290948
    Abstract: A catalyst for hydrogenation reaction processes includes an oxide substrate surface, a MOx promoter, where M is a transition metal or main group elemental oxide, the promoter being deposited on the substrate, and a platinum group catalytic metal.
    Type: Application
    Filed: April 11, 2017
    Publication date: October 11, 2018
    Inventors: Jeffrey C. BUNQUIN, Magali FERRANDON, Massimiliano DELFERRO
  • Publication number: 20180290949
    Abstract: The present invention relates to a palladium-based supported hydrogenation catalyst and a preparation method and application thereof. The catalyst is prepared by the following method: impregnating an Al2O3-containing carrier with an organic solution containing a bipyridine derivative having hydroxy group, optionally drying followed by impregnating with a mixed solution containing the main active component palladium ions and the auxiliary active component Mn+ ions, where M is one selected from Ag, Au, Ni, Pb and Cu; and then optionally drying, and calcining to obtain the catalyst. The preparation method provided by the present invention allows Pd atoms and M atoms to be highly uniformly dispersed on the carrier, which overcomes the adverse impact of the surface tension of the impregnation solution and the solvation effect on the dispersibility of active components.
    Type: Application
    Filed: June 15, 2018
    Publication date: October 11, 2018
    Inventors: Chunxia Che, Yulong Liang, Ying Qian, Wei Han, Feng Zhang, Galian Gou, Xilin Jing, Xiaoxin Chang, Qiang Gui, Lifen Gu, Wei Xie, Zhongdong Zhang, Dehua Huang, Duping Tan, Yuan Gao, Lin Cheng
  • Publication number: 20180290950
    Abstract: Improved methods of oxidative dehydrogenation (ODH) of short chain alkanes or ethylbenzene to the corresponding olefins, and improved methods of oxidative coupling of methane (OCM) to ethylene and/or ethane, are disclosed. The disclosed methods use boron- or nitride-containing catalysts, and result in improved selectivity and/or byproduct profiles than methods using conventional ODH or OCM catalysts.
    Type: Application
    Filed: May 31, 2018
    Publication date: October 11, 2018
    Inventors: Ive Hermans, Joseph Thomas Grant, Carlos Alberto Carrero Marquez, Alessandro Chieregato, Juan Mauricio Venegas
  • Publication number: 20180290951
    Abstract: There is provided a method of producing HFO with which diluent gas is easily separated even at a low boiling point and which has excellent productivity. A method of producing HFO includes: converting HFC of the formula (1) into the HFO of the formula (2) to obtain a first gas composition containing the HFO and the fluorine-containing solvent, CR1R2X1CR3R4X2 (1), CR1R2?CR3R4 (2), where in the formulae, R1 to R3 are H or F, R4 is H, F, CH3, CH2F, CHF2 or CF3, the total number of fluorine atoms of R1 to R4 is one or more, and the total number of hydrogen atoms of R1 to R4 is one or more. One of X1 and X2 is H, and the other of X1 and X2 is F; and separating the fluorine-containing solvent from the first gas composition to obtain a second gas composition containing the HFO.
    Type: Application
    Filed: June 13, 2018
    Publication date: October 11, 2018
    Applicant: ASAHI GLASS COMPANY, LIMITED
    Inventors: Yusuke TOMIYORI, Masahiko NAKAMURA
  • Publication number: 20180290952
    Abstract: Disclosed herein are embodiments of halogenated nanohoop compounds and assemblies thereof that can be used to for a variety of biological and chemical applications. The halogenated nanohoop compounds described herein exhibit non-covalent interactions that promote their ability to stack and form column-like assemblies having uniform pore size and that do not exhibit structural defects typically associated with other column-like structures, such as carbon nanotubes. Assemblies described herein also are capable of non-covalent interactions with other assemblies and thus can be used to form networks of the assemblies described herein.
    Type: Application
    Filed: February 20, 2018
    Publication date: October 11, 2018
    Applicant: University of Oregon
    Inventors: Ramesh Jasti, Jeff Van Raden, Erik Leonhardt
  • Publication number: 20180290953
    Abstract: In accordance with the present invention, disclosed herein is a method comprising the steps for producing lower molecular weight C1-C5 hydrocarbons and alcohols. Also disclosed herein, are systems utilized to produce low molecular weight C1-C5 hydrocarbons and alcohols.
    Type: Application
    Filed: May 5, 2016
    Publication date: October 11, 2018
    Inventors: Labeeb Chaudhary Ahmed, Khalid Karim, Ali Al-Hammad
  • Publication number: 20180290954
    Abstract: Disclosed is a method for recovering phenol and acetone from the cracking reaction product of bisphenol-A residue, by which economic feasibility and efficiency may be improved by utilizing a phenol/acetone purification process used for preparing bisphenol-A.
    Type: Application
    Filed: December 7, 2016
    Publication date: October 11, 2018
    Applicant: LG CHEM, LTD.
    Inventors: Sang-Beom LEE, Joon-Ho SHIN, In-Yong JEONG, Jong-Hui Park, Myeong-Yeon KEUM, Jeong-Ho KIM, Tae-Ho KIM
  • Publication number: 20180290955
    Abstract: An industrial scale continuous process for the production and recovery of cyclohexanone from phenol and hydrogen, said process comprising: hydrogenating phenol in a phenol hydrogenation reactor; separating cyclohexanone from a hydrogenated product stream in a separation and purification section [II] comprising at least 4 distillation sections; wherein at least some of the reaction heat produced in the phenol hydrogenation reaction section [I] is applied for the production of steam; and wherein the molar ratio of cyclohexanone to phenol that is charged to said phenol hydrogenation reactor is from 0.02 to 0.10; and/or wherein the molar ratio of cyclohexanol to phenol that is charged to said phenol hydrogenation reactor is from 0.001 to 0.10.
    Type: Application
    Filed: November 6, 2015
    Publication date: October 11, 2018
    Applicant: CAP III B.V.
    Inventors: Johan Thomas Tinge, Corinne Daguenet, Iris Verschuren, Wilhelmus Rudolf Maria Martens, Roeland Wilhelmus Theodorus Maria Brands, Robert Jan de Korte
  • Publication number: 20180290956
    Abstract: Method for hydroformylating cyclooctadiene using 2-(anthracen-9-yloxy)-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 11, 2018
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Katrin Marie DYBALLA, Robert FRANKE, Dirk FRIDAG, Dieter HESS, Detlef SELENT, Armin BÖRNER
  • Publication number: 20180290957
    Abstract: Process comprising the process steps of: a) initially charging a pentenoic ester, b) adding a ligand of structure 1 or 2: and a compound comprising a metal atom selected from: Rh, Ru, Co, Ir, c) supplying H2 and CO, d) heating the reaction mixture to convert the pentenoic ester to 5-formylpentanoic esters.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 11, 2018
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Stephan BEHRENS, Galina Morales TORRES, Armin BÖRNER, Robert FRANKE, Detlef SELENT
  • Publication number: 20180290958
    Abstract: Method for hydroformylating cyclooctadiene using 4-([1,1?:3?,1?-terphenyl]-2?-yloxy)-S-dinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepine.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 11, 2018
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Katrin Marie DYBALLA, Robert FRANKE, Dirk FRIDAG, Dieter HESS, Detlef SELENT, Armin BÖRNER
  • Publication number: 20180290959
    Abstract: The present invention relates to novel mixtures of cyclopentadecenone isomers, preparation thereof and use thereof as aroma substances, particularly as fragrances, and also aroma substance compositions and agents comprising said mixtures.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 11, 2018
    Inventors: FRAUKE THRUN, Joaquim Henrique TELES, Albert WERNER, Raff PELZER
  • Publication number: 20180290960
    Abstract: The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.
    Type: Application
    Filed: June 15, 2018
    Publication date: October 11, 2018
    Inventors: Li-Huei TSAI, Stephen HAGGARTY, Debasis PATNAIK, Ping-Chieh PAO
  • Publication number: 20180290961
    Abstract: A plant and a process may be utilized to isolate a carboxylic acid from a fermentation broth. The process may involve separating a biomass from the fermentation broth containing a salt of the carboxylic acid to produce a low-biomass solution. The separation of the biomass may be performed in a first step by centrifugation, separation, precoat filtration, or microfiltration, and in a second step by ultrafiltration. The process may further involve concentrating the salt of the carboxylic acid in the low-biomass solution. The concentrated solution may then be acidified. Further, precipitation of the carboxylic acid may be obtained by acidification.
    Type: Application
    Filed: August 26, 2016
    Publication date: October 11, 2018
    Applicants: THYSSENKRUPP INDUSTRIAL SOLUTIONS AG, thyssenkrupp AG
    Inventors: Joachim SCHÜTZE, Gerd BRAUN
  • Publication number: 20180290962
    Abstract: Methods and systems for producing alkyl hydroxyalkanoates from hydroxycarboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxycarboxylic acid recovery bottom, adding a mono-alcohol to the hydroxycarboxylic acid recovery bottom to obtain a first mixture, heating the first mixture, optionally in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
    Type: Application
    Filed: April 4, 2018
    Publication date: October 11, 2018
    Inventors: TIMOTHY WALTER ABRAHAM, RAVI R. GOKARN
  • Publication number: 20180290963
    Abstract: Disclosed herein are compounds for use as antimicrobial agents, having a structure of formula (I):
    Type: Application
    Filed: April 5, 2018
    Publication date: October 11, 2018
    Inventors: Allan James McKinley, Thomas V. Riley, Nigel Lengkeek, Scott Stewart, Ramiz Boulos
  • Publication number: 20180290964
    Abstract: The present invention is generally directed to methods of using novel crystalline forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol and pharmaceutical compositions comprising same.
    Type: Application
    Filed: June 14, 2018
    Publication date: October 11, 2018
    Inventors: Lloyd F. Mackenzie, Jeffery R. Raymond, Curtis Harwig, Ana Fernandez Casares
  • Publication number: 20180290965
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 11, 2018
    Inventors: Luis Brito, Delai Chen, Gabriel Grant Gamber, Andrew Geall, Kevin Love, Thomas Zabawa, Frederic Zecri
  • Publication number: 20180290966
    Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Olivier GAVELLE, Uwe GRETHER, Matthias NETTEKOVEN, Stephan ROEVER, Mark ROGERS-EVANS, Didier ROMBACH
  • Publication number: 20180290967
    Abstract: The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 11, 2018
    Inventors: Amit Basu, Christopher W. Reid, Mary Margaret O'Connor, Ethan Lindsay Magno, Mitchell Evan Jamieson, Ryan Daniel Miller
  • Publication number: 20180290968
    Abstract: The invention relates to a method for an economically and technically improved embodiment of a production interruption in a production method for isocyanates by phosgenation of the corresponding amines, in which the entire production plant is not closed while one or more parts of the plant is taken out of operation, rather the input materials and/or reaction products available in the production plant are recirculated through at least one part of the plant that has not been taken out of operation. The invention further relates to a plant for producing isocyanates and to a method for operating a plant for producing isocyanates.
    Type: Application
    Filed: September 20, 2016
    Publication date: October 11, 2018
    Inventors: Thomas Knauf, Dirk Manzel, Peter Plathen, Jürgen Spriewald
  • Publication number: 20180290969
    Abstract: The invention relates to a stabilizer for L-012 or a salt thereof, a stabilization method for L-012 or a salt thereof, coexisting with the stabilizer and L-012 or a salt thereof, and the like. The stabilizer is represented by Formula [1]: wherein p pieces of M1 each independently represent a hydrogen atom or an alkali metal atom, q pieces of R1 each independently represent a hydroxy group or a sulfonic acid group, m represents 0 or 1, p represents an integer of 1 to 3, q represents an integer of 0 to 4, Y represents a nitrogen atom or a CH group (a methine group), and Z represents an aryl group having a specific structure or a pyrazolyl group having a specific structure.
    Type: Application
    Filed: October 20, 2016
    Publication date: October 11, 2018
    Applicant: FUJIFILM WAKO PURE CHEMICAL CHEMICAL CORPORATION
    Inventors: Shinya KAJI, Toshinari OHASHI, Naoyuki YAMAMOTO
  • Publication number: 20180290970
    Abstract: A compound represented by formula (3): (wherein R1 represents a C1-C6 perfluoroalkyl group, R2 represents a C1-C6 alkyl group, and m represents an integer of 0 to 3) or a salt thereof, which is useful as a production intermediate of pharmaceuticals and agrochemicals, can be produced by reacting an alkali metal salt or zinc salt of a C1-C6 perfluoroalkanesulfinic acid with 2-aminophenol optionally substituted by 1 to 3 C1-C6 alkyl groups or a salt thereof in the presence of an oxidizing agent.
    Type: Application
    Filed: June 1, 2016
    Publication date: October 11, 2018
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Junichi ISHIKAWA, Koji HAGIYA, Mitsunobu KAWAMURA
  • Publication number: 20180290971
    Abstract: The present invention relates to purified compounds of 3-methanesulfonylpropionitrile, in which at least one of the hydrogen, oxygen, sulfur, and nitrogen atoms is substituted with a respective isotope that includes, but not limited to 2H (deuterium), 3H (tritium), 13C, 14C, 15N, 17O, 18O, and 35S. The purified compound has at least 90% purity. Preferred compounds are deuterated 3-methanesulfonylpropionitriles.
    Type: Application
    Filed: April 4, 2018
    Publication date: October 11, 2018
    Inventors: Gerald S. JONES, Scott A. GOODRICH, Joseph P. ST. LAURENT
  • Publication number: 20180290972
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Application
    Filed: April 3, 2018
    Publication date: October 11, 2018
    Inventor: Michael E. Silver
  • Publication number: 20180290973
    Abstract: A method for producing derivatives of N-retinoylaminoalkane sulfonic acid, the method comprising providing retinoic acid, chloroformate, aminoalkanesulfonic acid selected from the group consisting of cysteic acid and alkyl ester thereof, cysteinesulfinic acid and alkyl ester thereof, homocysteic acid and alkyl ester thereof, homocysteinesulfinic acid and alkyl esters thereof, taurine and derivatives thereof, and an organic solvent, and a base, mixing said components under substantial absence of oxidizing compounds thereby forming a reaction mixture comprising a liquid phase, wherein the liquid phase is one phase and the derivatives of N-retinoylaminoalkane sulfonic acid are formed in said liquid phase.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Inventors: Dzianis BABROU, Maryna BUDNIKAVA, Mikael BJÖRKLUND, Julian ALEKSOV
  • Publication number: 20180290974
    Abstract: Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect. The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 11, 2018
    Inventors: Hiroyasu Takahashi, Yoshifumi Saito, Kosuke Tsuda, Mitsuhito Shibasaki, Kohei Ohata
  • Publication number: 20180290975
    Abstract: The disclosure relates to a compound having Formula (I?): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 11, 2018
    Inventors: Nathanael S. GRAY, Michael ECK, Pasi JANNE, Hwan Geun CHOI, Jaebong JANG, Kwok-Kin WONG
  • Publication number: 20180290976
    Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 11, 2018
    Inventors: Brian K. Albrecht, James Edmund Audia, Alexandre Côté, Martin Duplessis, Victor S. Gehling, Jean-Christophe Harmange, Rishi G. Vaswani
  • Publication number: 20180290977
    Abstract: The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.
    Type: Application
    Filed: March 27, 2018
    Publication date: October 11, 2018
    Applicant: Albert-Ludwigs-University Freiburg
    Inventors: Roland Schule, Eric Metzger
  • Publication number: 20180290978
    Abstract: The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.
    Type: Application
    Filed: November 17, 2015
    Publication date: October 11, 2018
    Applicant: NIROGYONE THERAPEUTICS, INC.
    Inventors: Vincent SANDANAYAKA, Qiong WU