Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.

Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.

Abstract: Methods of separating chitin from a chitinous biomass that contains chitin and non-chitin material by a chemical pulping process that uses a protic ionic liquid or a composition comprising acid and base precursor molecules are described. Also described are methods for purifying chemically pulped chitin resulting in a pure chitin material with a high molecular weight and a higher degree of acetylation in comparison to traditional pulping and ionic liquid extraction based methods.

Abstract: The present invention is related to a process for the preparation of polymers containing amino groups by hydrogenation of nitrile groups containing polymers by heterogeneous catalysis.

Abstract: Process for functionalizing a polymer by treating said polymer at a temperature in the range 80-250° C. with a mono-azide of the formula wherein m is 0 or 1, n is 0 or 1, n+m=1 or 2, X is a linear or branched, aliphatic or aromatic hydrocarbon moiety with 1-12 carbon atoms, optionally containing heteroatoms, Rb is selected from the group consisting of hydrogen, linear and branched alkyl groups with 1-6 carbon atoms optionally substituted with O, S, P, Si, or N-containing functional groups, alkoxy groups with 1-6 carbon atoms, and halogens, and each Ra is individually selected from hydrogen, linear or branched alkyl groups with 1-6 carbon atoms, or may form a saturated or unsaturated aliphatic or aromatic ring structure with at least one other Ra.

Abstract: A method for manufacturing a polymer compound which has a constituent unit (a10) which includes a hydroxy group and a constituent unit (a1) which includes an acid decomposable group of which a polarity increases due to an effect of an acid, the method including copolymerizing a monomer for deriving a constituent unit (a0) which includes a group which protects a phenolic hydroxyl group or a hydroxy group of a carboxy group with an organic silicon compound and a monomer for deriving the constituent unit (a1) and obtaining a prepolymer which has the constituent unit (a0) and the constituent unit (a1), and selectively deprotecting the constituent unit (a0) by reacting a compound which has a fluoride anion with the prepolymer and obtaining a polymer compound which has the constituent unit (a10) and the constituent unit (a1).

Abstract: Processes for preparing a polyethylene in at least one continuously stirred tank reactor are described herein. The process may comprise the step of: polymerizing ethylene in the presence of at least one supported metallocene catalyst, a diluent, optionally one or more co-monomers, and optionally hydrogen, thereby obtaining the polyethylene, wherein the supported metallocene catalyst comprises a solid support, a co-catalyst and at least one metallocene, wherein the solid support has a surface area within the range of from 100 to 500 m2/g, and has a D50 value within the range of from 4 ?m to 18 ?m, with D50 being defined as the particle size for which fifty percent by weight of the particles has a size lower than the D50; and D50 being measured by laser diffraction analysis on a Malvern type analyzer. Polyethylene obtained by the disclosed process and articles comprising the polyethylene are also described.

Abstract: The present invention provides a solid organomagnesium precursor having formula {Mg(OR?)X}.a{MgX2}.b{Mg(OR?)2}.c{R?OH}, wherein R? is selected from a hydrocarbon group, X is selected from a halide group, and a:b:c is in range of 0.01-0.5:0.01-0.5:0.01-5 and process for preparing the same, said process comprising contacting a magnesium source with a solvating agent, an organohalide and an alcohol to obtain the solid organomagnesium precursor. The present invention also provides a process for preparing a catalyst system using the organomagnesium precursor and its use thereof for polymerization of olefins.

Abstract: Alkoxylated fatty acids are disclosed herein, as well as methods of making and using such compounds. In some embodiments, the alkoxylated fatty acids are formed from monomers derived from natural oils. In some embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic latex by emulsion polymerization. In some other embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic rubber, such as styrene-butadiene rubber. In some other embodiments, the alkoxylated fatty acids are used as surfactants in a composition for treatment of gas or oil wells, for cleaning applications, for use in various laundry-related applications, for use in personal care compositions, or for use as solvents for coating applications, such as reactive and non-reactive waterborne coating applications.

Abstract: Provided is a dispersant used for dispersion of metal particles, the dispersant including: a constituent unit derived from a compound represented by General Formula (I) below; and a constituent unit derived from a compound having an ionic group, where in General Formula (I) above, R1 is a hydrogen atom or a methyl group, x is a natural number of 2 or greater, and n is a natural number of 1 or greater.

Abstract: A silane-grafted polyolefin composition is disclosed, and includes a desired reduced specific weight material. The composition finds application in a wide array of uses, and in particular automotive and uses such as hoses, where this composition is used in place of conventional materials such as TPV and EPDM rubber formulations.

Abstract: Materials having structure (1), wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or a C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a non-polar polymer formed by metallocene catalysis and polymer B is a polymer formed by radical catalysis of a polar monomer are used as polymer additives particularly to improve the compatibility of mixtures of polymers.

Abstract: Tertiary amine catalysts having isocyanate reactive groups that are capable of forming thermally stable covalent bonds able to withstand temperatures up to 120° C. are disclosed. These catalyst can be used to produce polyurethane foam having the following desirable characteristics: a) very low chemical emissions over a wide range of environmental conditions and isocyanate indexes (e.g. indexes as low as 65 but higher than 60) while meeting all physical property requirements; b) sufficient hydrolytic stability to maintain the catalyst covalently bound to foam without leaching of tertiary amine catalyst when foam is exposed to water or aqueous solutions even at temperatures higher than ambient (temperature range 25° C. to 90° C.

Abstract: The invention provides a polyphenylene ether modified phenol-benzaldehyde multifunctional epoxy resin with formula (I) wherein A is: PPE are: Z are: Y are: Their manufactured is following steps: polyphenylene ether 100 parts is dissolved in solvent, then phenol-benzaldehyde multifunctional epoxy resin 100˜450 parts and catalyst 0.01˜5 parts are added, stirred and mixed at 90˜180, for 1˜4 hour, to obtain formula (I) solution. Said product is formulated with compositions for laminate, having excellent electrical properties and heat resistance. The dielectric constant is 4.03(1 GHz), dissipation factor is 0.0046(1 GHz) and no delamination longer than 60 minutes dipping in 288 soldering test after 2 hours pressure cooking test. Application is insulating materials for highly reliable electronic components such as EMC, PCB substrates, laminate and insulating plates.

Abstract: Described herein are heterocyclic organic compounds. More specifically, described herein are compounds based on the combination of fused pyrrole structures with diketopyrrolopyrrole structures, methods for making these compounds, and uses thereof. The compounds disclosed have improved electronic, polymerization and stability properties that allow for improved material processability and inclusion in organic semiconductor devices.

Abstract: The present invention provides a method of preparing an amine-functionalized (e.g. amine-terminated) polyaryletherketone polymer, or imide- or sulphone-copolymer thereof and amine-protected analogs thereof, said method comprising the step of polymerizing a monomer system in a reaction medium comprising a capping agent comprising —NR2, —NRH or a protected amine group.

Abstract: Polymers, including polyesters and polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock, and methods of making and using those polyesters and polycarbonates are described. The method includes reacting a bis-furan diol with a dicarboxylic acid in the presence of a carbodiimide to produce the bis-furan containing polymers. In certain embodiments, the dicarboxylic acid is succinic acid, the bis-furan diol is the 5,5?-(propane-2,2-diyl)bis(furan-2,5-diyl) dimethanol, and the carbodiimide is of N,N-diisopropylcarbodiimide.

Abstract: The present invention relates to a compound obtainable by the condensation of a polyol having 3-4 hydroxyl groups, adicarboxylic acid or a derivative thereof, an alkanolamine and a fatty acid, followed by reaction with an alkylating agent. This compound is useful as a collector in a process for the reverse froth flotation of non-sulfidic ores containing silicate as impurities, especially phosphate ores.

Abstract: An organic zinc catalyst having more uniform and fine particle size and showing more improved activity in a polymerization process for the preparation of a poly(alkylene carbonate) resin and a preparation method thereof, and a method of preparing a poly(alkylene carbonate) resin using the organic zinc catalyst, are provided. The preparation method of the organic zinc catalyst includes the steps of surface-treating a zinc precursor with a dispersant, and reacting the surface-treated zinc precursor with dicarboxylic acid to form a zinc dicarboxylate-based catalyst.

Abstract: The present invention provides specific alkoxylation products, a process for preparing them, compositions which comprise these alkoxylation products, and the use thereof.

Abstract: A process of living ring-opening polymerization comprising the step of exposing ?-amino acid N-carboxyanhydride monomers to an initiator having a formula NH2CH2[CH2NHCH2]nCH2NH2, wherein n is an integer with value of 1-3 to obtain amino acid polymers, including homopolymers or block copolymers. Use of triethylenetetramine, diethylenetriamine and tetraethylenepentamine exemplified. Representative examples of block copolymers include poly(benzyl-L-glutamate) and poly(benzyl-L-lysine).

Abstract: Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.

Abstract: A composition for preparing a polyimide including a tetracarboxylic dianhydride mixture including a tetracarboxylic dianhydride represented by Chemical Formula 1A, Chemical Formula 1B, or a combination thereof, a tetracarboxylic dianhydride represented by Chemical Formula 2, and a diamine represented by Chemical Formula 3: NH2—R1—NH2??Chemical Formula 3 wherein in Chemical Formulae 1A, 1B, 2 and 3, definitions of groups and substituents are described in the specification.

Abstract: The present invention relates to a polymer, and a composition containing a particulate solid, an aqueous medium, and a polymer chain having at least one fused aromatic imide pendant group. The invention further provides compositions for millbases, dispersions, coatings and inks.

Abstract: A poly(imide-amide) copolymer includes: an imide structural unit which is a reaction product of a first diamine and a dianhydride, and an amide structural unit which is a reaction product of a second diamine and a diacyl halide, wherein each of the first diamine and the second diamine includes 2,2?-bis-trifluoromethyl-4,4?-biphenyldiamine, and at least one of the first diamine and the second diamine further includes a compound represented by Chemical Formula 1, wherein the dianhydride includes 3,3?,4,4?-biphenyltetracarboxylic dianhydride and 4,4?-hexafluoroisopropylidene diphthalic anhydride, wherein the diacyl halide includes terephthaloyl chloride (TPCl), and wherein an amount of the compound represented by Chemical Formula 1 is less than or equal to about 10 mole percent based on the total amount of the first diamine and the second diamine: NH2-A-NH2??Chemical Formula 1 wherein in Chemical Formula 1, A is the same as described in the detailed description.

Abstract: In some cases, fabricating a high refractive index polymer composite may include combining a thiol monomer and an ene monomer to yield a composite mixture, heating the composite mixture to yield a homogenous composite mixture, and curing the homogeneous composite mixture to yield a polymer composite, wherein the ene monomer comprises zirconium oxo (meth)acrylate clusters. The refractive index of the high refractive index polymer composite may be at least 1.70. In certain cases, fabricating a high reactive index polymer composite includes combining a vinyl (ene) monomer, a thiol monomer, and zirconium oxo (meth)acrylate clusters to yield a composite mixture, heating the composite mixture to yield a homogenous composite mixture, and curing the homogeneous composite mixture to yield a polymer composite. The refractive index of the high refractive index polymer composite may be at least 1.75.

Abstract: The present invention relates to a polyorganosiloxane and a moisture and radiation curable adhesive composition comprising the same, in particular, to a polyorganosiloxane and a moisture and radiation curable adhesive composition used in a liquid optical clear adhesive (LOCA) for handheld device and display (HHDD).

Abstract: The curable resin composition of the present technology includes: (A) a straight-chain organopolysiloxane having at least two silicon-bonded hydrogen atoms and at least one aryl group in one molecule and having an average degree of polymerization of greater than 10; (B) a branched-chain organopolysiloxane having at least three alkenyl groups and at least one aryl group in one molecule; and (C) a hydrosilylation reaction catalyst; wherein a proportion of diphenylsiloxane units relative to an amount of all siloxane units is 10 mol % or greater, and the all siloxane units containing siloxane units derived from the straight-chain organopolysiloxane (A) and the branched-chain organopolysiloxane (B).

Abstract: The invention relates to a method for making a lignin component from lignin material by an acid treatment, the method comprising: subjecting the lignin material to at least one acid treatment stage by mixing the lignin material with an acid composition to produce an acid treatment mixture, wherein at least one acid treatment stage has a retention time over 6 hours and wherein the acid treatment mixture is held at a temperature of over 60° C. and a pH of 0.5-4 for the retention time of the acid treatment in order to increase dry solids content of the lignin component and decrease ash and carbohydrates of the lignin component. Further, the invention relates to corresponding lignin components, a use of the lignin component and a product.

Abstract: The present invention deals with a process for producing pellets from olefin copolymers. The process comprises: (i) melting the olefin copolymer in an extruder; (ii) extruding the molten olefin copolymer through a die plate into a pellet water bath in a pelletizer thereby producing strands of the olefin copolymer; (iii) cutting the strands of the olefin copolymer in the pelletizer into pellets; and (iv) drying the pellets. The pellet water in the pelletizer contains from 0.1 to 5% by weight of a colloidal silica based on the weight of the water.

Abstract: A masterbatch having reactive silicone as a hydrophobic additive, the polyester compound that the silicone-containing masterbatch has been let down into, and the plastic articles and films from such compounds having enhanced hydrophobic properties are disclosed. Films having a Water Contact Angle of at least 76° (ASTM D7490-08) are exemplified.

Abstract: Disclosed herein is a superabsorbent polymer with a surface crosslinked with a water-soluble polyvalent cationic salt, a polycarbonic acid-based copolymer, and a surface crosslinking agent wherein an improvement is brought about in physical properties, with the concomitant reduction of process time and cost. Also, a method is provided for preparing the surface-crosslinked superabsorbent polymer.

Abstract: The present disclosure relates to a polyamide-based polymer composition with superior fluidity and a polyamide-based composite material with superior mechanical strength prepared therefrom. More specifically, it relates to a polyamide-based polymer composition containing 0.1-5 parts by weight of dicyclohexylmethane bisdecanoamide, which is a cyclic compound, as a fluidity control agent based on 100 parts by weight of a mixture consisting of 20-90 wt % of a polyamide-based resin and 10-80 wt % of a reinforcing fiber, a polyamide-based composite material prepared using the same, and a method for preparing the same. The polymer composition according to the present disclosure, wherein dicyclohexylmethane bisdecanoamide is used as a fluidity control agent, provides an effect of reducing friction between a molten resin and a processing machine and greatly reducing torque by effectively dispersing a reinforcing fiber in a polyamide-based resin.

Abstract: Provided is a windable thin single layer film comprising a xylylenediamine-based polyamide resin. A polyamide resin film comprising a polyamide resin (C) obtained by polycondensing a diamine structural unit of which 70 mol % or more is derived from xylylenediamine (A) with a dicarboxylic acid (B), wherein the film has a thickness of 10 to 50 ?m and is textured on the surface.

Abstract: The present invention provides crosslinked epoxy-functional copolymer films and microarrays built from the crosslinked epoxy-functional copolymer films. Microarrays incorporating the copolymers include a substrate on which a film of the crosslinked epoxy-functional copolymer is disposed and target molecules bound to the copolymer film. The crosslinked polymer films are well-suited for use as scaffolds for target molecules in microarrays because they provide a high density of binding sites for the target molecules, are mechanically stable, and may be coated onto a wide range of substrates.

Abstract: A manufacturing method that forms a multilayer thin film on the inner surface of a housing forming a transparent appearance of an electronic product to provide a deep metal texture and an electronic product having a metal texture provided at the inner surface of the housing. The multilayer thin film manufacturing method includes reforming an inner surface of a housing having an outer surface and the inner surface through plasma processing, depositing at least one hardness reinforcement layer on the inner surface, and depositing a color layer on the hardness reinforcement layer.

Abstract: Siliconized release film for the production of polymer moldings from fiber composites using a mold, which comprises a support film which is capable of vacuum deep drawing at room temperature and a coating which can be applied in liquid form and consists, optionally after removal of any solvent, of more than 90 atom % of silicon, carbon and/or oxygen, more than 45 atom % of carbon and more than 20 atom % of silicon, in each case based on the total coating and measured by XPS, characterized in that the coating has been crosslinked by means of condensation reactions, addition reactions or radiation.

Abstract: A method of producing a polyethylene resin expanded molded product includes filling a mold with expanded polyethylene resin particles, wherein an internal pressure of 0.12 to 0.16 MPa is applied to the expanded polyethylene resin particles in the mold, and forming the polyethylene resin expanded molded product by heating the expanded polyethylene resin particles and fusing the expanded polyethylene resin particles. The expanded polyethylene resin particles includes 100 parts by weight of a polyethylene resin, 0.08 to 0.25 parts by weight of a cell nucleating agent, 0.3 to 0.8 parts by weight of a polyhydric alcohol fatty acid ester, and 0.01 to 10 parts by weight of a hydrophilic compound, each of the expanded polyethylene resin particles having a weight of 2.5 to 3.5 mg. The polyethylene resin expanded molded product has a density of 0.017 to 0.021 g/cm3 and a thickness of 10 to 40 mm.

Abstract: The invention relates to a method for producing a binder foam for producing asphalt. In a pressurized stream of heated binder a liquid, which has a lower evaporation temperature under atmospheric pressure than the temperature of the heated binder stream is injected at an angle (?) of greater than 90° relative to the flow direction (S) of the binder stream such that a pressurized mixture stream of the binder with drops of liquid distributed therein or with drops of liquid distributed therein and vapor bubbles resulting from said drops is provided downstream of the injection point (D). The pressure of said mixture stream is then decreased whereby the binder is foamed as a result of an evaporation of the drops of liquid contained in the binder and/or as a result of the expansion of the vapor bubbles resulting from the drops of liquid.

Abstract: The inventions is directed to a method for recovering support materials used in an additive manufacturing process. The method comprises exposing a precursor additive manufactured article comprised of a water soluble support polymer and an insoluble material to water. The water soluble support polymer is dissolved in the water. The remaining article is then removed from the water. The dissolved water soluble polymer is precipitated from the water. The precipitated polymer is separated from the water and any remaining water removed to recover the water soluble support polymer. The recovered water soluble support polymer may then be re-used to make further additive manufactured articles.

Abstract: Aniline monomers are subjected to a chemical oxidative polymerization in the presence of a templating compound and a primary dopant to obtain polyaniline nanostructures with a first morphology. The obtained polyaniline nanostructures are doped with a secondary dopant to obtain polyaniline nanostructures with a second morphology.

Abstract: A composition comprising: (a) a thermoplastic polymer; (b) a plurality of particles, each said particle having core-shell structure and comprising, (i) a core comprising one or more magnetic materials and (ii) a shell comprising silicon dioxide; wherein the composition comprises particles (b) in an amount from 2 to 15 wt % is provided. Further provided is a connector comprising the composition, a system comprising the connector and a process for improving bonding between two or more means for conveying fluids.

Abstract: A resin composition comprising 100 parts by mass of a polymer (A) and 0.5 parts to 60 parts by mass of a high dielectric material (B), the high dielectric material (B) having a relative dielectric constant at 20° C. of 10 or more, a melting point of 45° C. or lower, and a boiling point of 150° C. or higher.

Abstract: Plasticizers comprising a succinate ester and an epoxidized natural oil and plasticized polymeric compositions comprising such plasticizers. Such plasticized polymeric compositions can be employed in forming various articles of manufacture, such as coated conductors.

Abstract: Provided is an additive masterbatch comprising a low-melting-point resin additive at a high concentration, which additive masterbatch can be continuously produced without strand breakage, shows excellent clumping resistance to inhibit bleeding from a pellet thereof and thus has few use restrictions for potential application. The resin additive masterbatch is characterized by comprising, with respect to 100 parts by mass of (A) a polyolefin resin: 50 to 200 parts by mass of (B) a resin additive having a melting point of not higher than 65° C.; and 10 to 20 parts by mass of (C) an inorganic layered compound.

Abstract: The present application relates to a process for producing a composition comprising at least one acrylamide polymer P and at least one stabilizer St, wherein the acrylamide polymer P is obtained in the form of a polymer gel, and the acrylamide polymer gel having a water content in the range from 50% to 80% by weight, based on the overall polymer gel, is treated with an aqueous solution SS comprising at least one stabilizer St selected from the group consisting of sulfur compounds, N-oxides, organic nitroso compounds, aromatic hydroxyl compounds and ketones.

Abstract: In general the present disclosure relates to Nylon 6/montmorillonite clay nanocomposites with enhanced mechanical properties that have been prepared primarily by solution compounding. A major challenge in producing the Nylon 6/montmorillonite clay nanocomposites is associated with the exfoliation and dispersion of the clay particles within the polymer matrix. This disclosure presents compositions and methods for obtaining highly or fully exfoliated nylon 6/montmorillonite nanocomposites, not only for organically modified clays with known compatibility with nylon 6 (Cloisite 30B), but also for clays with low/no compatibility with nylon 6 (Cloisite 15A and Na+-MMT) through solution compounding.

Abstract: A resin particle composition includes resin particles, inorganic particles surface-treated with oil, and silica particles having a compression aggregation degree of 60% to 95% and a particle compression ratio of 0.20 to 0.40.

Abstract: Provided is a foamed product having excellent cold insulting effect as a heat insulating material or the like for cold insulation of a cold insulation container. The foamed product 1 includes a paper pellet of 50.0 to 70.0% by mass, a polypropylene resin group of 22.0 to 34.0% by mass, a low density polyethylene resin of 3.0 to 20.0% by mass, and a compatibilizing agent of 0.6 to 2.0% by mass of the polypropylene resin and the polyethylene resin. The paper pellet is formed by mixing fine paper powder of 30.0 to 50.0% by mass having a particle diameter of 30 to 200 ?m and hydrophilic macromolecule of 50.0 to 70.0% by mass. The polypropylene resin group is composed of foamable polypropylene resin of 5.0 to 11.0% by mass and other polypropylene resin of 17 to 23% by mass.

Abstract: An emulsion stabilizer includes a biopolymer blend of one or more cellulose ether and one or more cross-linked, modified starch wherein one or more of the cellulose ether or the cross-linked, modified starch is hydrophobically modified and wherein the total amount of cellulose ethers in the biopolymer blend is not greater than 50 wt %. The invention further relates to emulsion compositions comprising the emulsion stabilizer, and particularly oil-in-water emulsions. In one embodiment the emulsions are suitable for use in personal care formulations.