Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.

Abstract: A composite dura substitute implant for implantation at a dura defect site having a porous layer that provides an osteoconductive scaffold for bony ingrowth, a porous layer that provides a scaffold for regeneration of collagen at a dura surface, and an intervening layer for preventing cerebrospinal leakage is disclosed. The composite dura substitute implant facilitates regeneration of dura mater and promotes osteointegration with bony tissue. Methods of manufacturing such an implant and methods of treatment using such composite dura substitute implants are further disclosed.

Abstract: Methods and compositions for repair and regeneration of neural tissue are provided. Particularly, methods and compositions for promoting neural tissue wound healing and treatment of traumatic brain injury using porous crystalline calcium carbonate particles and a biocompatible polymer, for example compositions comprising porous coral exoskeleton particles in combination with a biocompatible polymer, and optionally comprising neural growth agents and platelets for application to damaged neural tissue for enhancing neural regrowth and recovered functionality, in, for example, but not limited to, traumatic brain injury (TBI).

Abstract: The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.

Abstract: A functionalized tissue having covalently bound antibiotics and methods for producing the functionalized tissue having bound antibiotics comprising; providing a tissue having a sufficient number of primary amine groups on the tissue; coupling and deprotecting one or more F-moc AEEA linkers using HATU chemistry to the primary amine groups; and coupling an antibiotic to said AEEA linkers using HATU chemistry.

Abstract: Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

Abstract: An intermixed particulate bioresorbable material including cathodic particles and anodic particles bound to each other, wherein the anodic and cathodic particles are made respectively of an anodic and a cathodic material, the anodic and cathodic materials forming a galvanic couple. The anodic and cathodic particles are present in a predetermined ratio and the anodic particles, cathodic particles and predetermined ratio are such that bioresorption of the bioresorbable material is promoted by galvanic corrosion between the anodic and cathodic materials. Also, a medical device, manufactured using the bioresorbable material and a method of manufacturing the bioresorbable material and the medical device.

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.

Abstract: A bioresorbable haemostatic foam sponge for adhering to a wound. The sponge has a tissue-contacting surface divided into a plurality of closely-spaced tissue contacting elements. Also disclosed are methods for forming the haemostatic sponge and methods of using the sponge.

Abstract: In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.

Abstract: Provided herein is a wound drain useful in negative pressure wound treatment therapy. The wound drain advantageously includes structural components that prevent the drain from collapsing under negative pressure and from ingesting foreign materials introduced into a wound cavity, such as gauze and sponges, which con obstruct exudate flow through the drain. The wound drain may further comprise a dual lumen configuration such that it advantageously can be used in for positive pressure applications, or for combined negative and positive pressure treatments.

Abstract: A device for filtration of fat extracted during liposuction procedures. The device includes: a first reservoir filled with a physiological solution adapted to be suctioned by a syringe containing fat mixed with blood and anesthetic; a second reservoir, empty, intended to receive cyclically from the syringe a liquid mixture consisting of the suctioned solution, blood and anesthetic separated from the fat; and at least one filter element provided with a connection member for connection of the syringe, the filter element being connected to the first reservoir and the second reservoir through a three-way connector. A first one-way valve configured to allow passage of a flow of fluid from the first reservoir towards the connector is arranged on a branch of the connector connected to the first reservoir. A second one-way valve configured to allow passage of a flow of fluid from the connector towards the second reservoir is arranged on a branch of the connector connected to the second reservoir.

Abstract: A baby product sterilizer having a breast pump includes: a body having a cap disposed openably and closably on the front surface thereof and a plurality of ultraviolet lamps located at the inside thereof to sterilize and dry baby products accommodated therein; a cover located at outer surfaces of the body; and the breast pump disposed between the body and the cover in such a manner as to be controlled by a controller mounted on the cover.

Abstract: The present invention relates to a pump arrangement (1) for a double breast pump (2). The pump arrangement (1) comprises first and second terminals (23, 24) for connecting first and second expression kits (3, 4) having first and second breast shields (5, 6) and at least one container (7) for collecting breast milk (8) in fluidic connection with the expression kits (3, 4), a pump (9) for generating reduced pressure within said breast shields, a plurality of conduits (10, 11, 14, 15, 16), a suction valve (12) connected to the pump (9) by a connection conduit (14) and to the first and second terminals (23, 24) by respective air conduits (10, 11), and a venting valve (13) connected to the first and second terminals (23, 24) by venting conduits (15, 16), wherein the venting valve (13) comprises an opening (17) to the environment. The pump (9) is alternatingly connected to the first and second terminals (23, 24) by alternate opening and closing of the suction valve (12) and the venting valve (13).

Abstract: The strain relief device of this invention reduces injury and danger of serious infection at driveline skin exit sites caused by routine patient activities and accidental stresses on the drivelines of ventricle assist devices and similar externally powered implanted medical devices. The device comprises a sleeve that forms an adherent biological interface with the skin and compliant seals between the sleeve and driveline. The compliant seals mechanically decouple linear and rotary driveline motions from the sleeve, while isolating the patients internal tissue from the outside environment. This mechanical decoupling reduces stresses and injury to the adherent interface, thereby reducing the risk of bacterial entry and infection. The device may be inserted into the patient as part of the driveline assembly implantation procedure, and is positioned such that the skin contacts and adheres to the outer diameter of the sleeve.

Abstract: An implantable fluid pump system is disclosed for supporting or initiating flow inside a hollow organ through which fluid circulates, in particular the heart. The fluid pump system comprises an intracardiac module, which includes two separate fluid channels, each of which possesses an intracardiac fluid channel opening and, located opposite the latter, an extracardiac fluid channel opening, a fastening module, which provides a joining contour for purposes of joining onto the intracardiac module in a fluid-tight manner, and a fastening structure for purposes of intracorporeal fastening onto the hollow organ, and a pump module, which can be mounted in a releasable manner directly or indirectly onto the intracardiac module, and can be attached in a fluid-tight manner to the extracardiac fluid channel openings in order to produce a fluid-tight connection of both fluid channels.

Abstract: Connectors interfacing a mechanical circulatory system with a patient's natural vasculature are provided herein. Such connectors include aortic connectors that facilitate fluid coupling of an outflow graft tube from an implanted blood pump with a patient's aorta. Aortic connectors can include a substantially planar portion configured for sealed attachment with a wall of the aorta and a tubular connector portion extending from an inlet opening to an outlet opening. The substantially planar portion can include a flexible membrane for attachment to an outer surface of the aorta and/or a flange for engagement with an inner surface of the aorta. The tubular connector can extend from the substantially planar portion at a pre-determined angle and include one or more attachment features to facilitate rapid fluidly sealed attachment to the outflow graft tube.

Abstract: An implantable blood pump comprising a housing. At least one stator is disposed within the housing. A rotor is disposed within the housing, the at least one stator being configured to rotate the rotor when current is applied to the stator. At least one at least partially piezoelectric disk is disposed within the housing.

Abstract: The application relates to a pump, in particular blood pump. The pump comprises a drive shaft (3) which runs in an axial direction, a delivery element (6) which is connected to the drive shaft (3) in a distal region of this, and a housing (5) which surrounds the delivery element (6). The delivery element (6) and the housing (5) are designed in a manner such that these automatically unfold after a forced compression. The housing (5) moreover comprises an inlet region (22) with at least one inlet opening (23), a fluid-tight region (20) which surrounds a region of the delivery element (6), and an outlet region (24) with at least one opening (23) for the exit of the pump medium. The delivery element (6) is arranged in a manner such that it projects into the outlet region (24).

Abstract: The present application relates to a blood pump, preferably for assisting a heart, wherein the blood pump comprises a housing with a distal inlet, a proximal inlet, and a mandrel arranged between the inlet and the outlet. A rotor with blading is arranged on the mandrel coaxially and rotatably. The rotor is mounted on the mandrel magnetically in an axial direction. In one embodiment the outlet is situated proximally to a proximal end of the blading of the rotor.

Abstract: A blood pump, such as an axial flow pump, having a pump housing, the pump housing defining a flow path and having a tapered portion adjacent to an outlet, tapering toward the outlet, an outflow cannula connected to the outlet of the pump housing, and an impeller and diffuser, disposed in the pump housing, the diffuser having a tapered body corresponding to the tapered portion of the pump housing, the diffuser body having at least one vane extending therefrom, the vein tapering in the same direction as the diffuser body. The present invention also includes a method of manufacturing the blood pump and a method of implanting the blood pump.

Abstract: Apparatus and methods are described including identifying a subject as suffering from cardiac dysfunction, congestive heart failure, reduced renal blood flow, increased renal vascular resistance, arterial hypertension, and/or kidney dysfunction, and, in response thereto, reducing blood pressure within a renal vein of the subject, by activating at least one impeller to pump blood from the renal vein into a vena cava of the subject, by the impeller rotating.

Abstract: An intermediate element for a medical extracorporeal fluid line designed to conduct a fluid, such as blood, has a main part extending between two connection parts. A flow channel passes continuously through the main part and the connection parts. The connection parts hydraulically connect the main body to a fluid line. On the periphery of the main part a receiving area is arranged, which is designed to receive a measurement value transmitter. An opening to the flow channel is defined in the receiving area and is sealed in a fluid-tight manner towards the receiving area by an elastic element. The measurement value transmitter is a gas sensor of a sensor device for measuring at least one gas contained in the fluid. The elastic element is a diffusion element, which is permeable to at least one gas. The diffusion element is bonded to an edge of the opening.

Abstract: Provided is an extracorporeal filtration and detoxification system and method generally including separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient.

Abstract: An example dialysis system includes a dialysis machine and a receiver coded with at least one of an address or a personal identification number (“PIN”). The dialysis machine is configured to perform a prescribed dialysis treatment on a patient, generate ultrafiltration (“UF”) removed data over the prescribed dialysis treatment performed by the dialysis machine, and transmit the UF removed data. The example receiver is configured to receive sensor data from a sensor attached to the patient. The at least one coded address or PIN ensures that the sensor data is received by the receiver as opposed to another receiver.

Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Abstract: Disclosed is a method for treating of Cockayne Syndrome (CS). Specifically, the invention pertains to a method for the extracorporeal treatment of a body fluid by removing the body fluid from a living body diseased with CS, and applying a targeted antibody conjugated to a moiety to at least one Cockayne Syndrome antigen in the body fluid, creating an antibody-antigen moiety complex, removing antibody-antigen moiety complex from the body fluid, and returning the purified body fluid to the body.

Abstract: The present invention relates to an apparatus for a pressure-based detection of a clot in an extracorporeal blood circuit, wherein the apparatus comprises at least one cyclically operating pump for conveying the fluid located in the extracorporeal circuit and at least one pressure sensor which is arranged to determine the current pressure development over time in the fluid conveyed by the pump in a current conveying cycle of the pump, wherein the apparatus has at least one memory in which at least one reference pressure development is stored which is based on at least one pressure development over time which was determined in a conveying cycle of the pump preceding the current conveying cycle of the pump, and wherein the apparatus comprises at least one evaluation unit which is configured such that it compares the current pressure development with the reference pressure development over a corresponding time.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: Methods and systems for obtaining platelets are disclosed. Platelets are collected in a pre-determined volume of plasma and a determined amount of a combined storage medium including the pre-determined amount of plasma and a volume of a synthetic additive solution.

Abstract: A variable rate controlled delivery drive mechanism includes a drive mechanism housing, at least partially within which initially resides a biasing member positioned in an initially energized state within an inner cavity of a piston. The drive mechanism may include a gear drive having one or more screws and one or more corresponding nuts. The piston contacts a plunger seal and is configured to axially translate the plunger seal, by force asserted upon it from the biasing member, from a first position to a second position within a drug container for drug delivery. The biasing member is metered from free expansion from its energized state by the gear drive and a gear assembly mechanism having a motor. A drug delivery pump utilizes such variable rate controlled delivery mechanisms. A status reader configured to recognize one or more corresponding status triggers is utilized to provide feedback to a user.

Abstract: A pressure jacket for use with a fluid injector may have a pressure jacket body having a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a pressure jacket longitudinal axis. The pressure jacket may further have at least one resiliently deflectable retaining member having a first segment attached to the pressure jacket body and a second segment protruding from the first segment toward the distal end of the pressure jacket body and deflectable relative to the first segment. The pressure jacket may further have at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member may interact with a housing of the fluid injector when the pressure jacket is connected to the housing to deflect the at least one resiliently deflectable retaining member upon rotation of the pressure jacket.

Abstract: A liquid drug-filtering filter medium is provided, which can include a nanofiber web having a three-dimensional network structure for filtering foreign substances included in a liquid drug. According to the embodiment, the occurrence of differential pressure when drawing in and filtering a liquid drug is minimized, and thus the liquid drug may be quickly drawn into a syringe cylinder within a short time and by applying small force, and at the same time, the filtration rate of foreign substances in the liquid drug is very outstanding. A method for producing the liquid drug-filtering filter medium is also provided, which enables the very easy adjustment of a pore structure of the filter medium or the diameters of the pores in order to enable the pore structure to minimize the occurrence of differential pressure or change the differential pressure to a target level.

Abstract: The present invention relates to an intravenous infusion set providing delivery of intravenous fluid to patients. An intravenous infusion set (10) to administer continuous air free delivery of intravenous fluid to a patient, said intravenous infusion set (10) comprising: a drip chamber (12), a flexible infusion line (22) of sufficient length connecting a lower end (20) of the drip chamber (12) to a standard connector (24) at the patient end so that a needle or a catheter could be connected to the patient; a roller clamp (26) arranged between the drip chamber (12) and the standard connector (24) being movable along the length of the flexible infusion line (22), said drip chamber (12) provided with a spike (14) on the upper end (16) and a flow regulating and stopping member (18) at its lower end (20) configured to administer continuous air free delivery of intravenous fluid to patients.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: Method and system for providing data monitoring and management including RF communication link over which a transmitter and a receiver is configured to communicate, the transmitter configured to periodically transmit a data packet associated with a detected analyte level received from an analyte sensor, and the receiver configured to identify the transmitter as the correct transmitter for which it is configured to receive the data packets, and to continue to receive the data packets from the transmitter once the transmitter identification has been verified, is provided.

Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Abstract: Described herein are assisted syringes. The syringes provide a higher force to the plunger tip than the extrusion force applied to the plunger. The assisted syringes can be used to inject or extrude viscous materials.

Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.

Abstract: A syringe and device for rapidly loading and releasing the syringe. A limiting flange and clamping flange are on a connection end of the syringe. The clamping flange is proximate to a rear end of the connection end and includes at least two clamping portions. The device includes an injection head, pushing ring, guide sleeve, and at least two bayonet locks. The bayonet locks are on the injection head by first elastic structures flexible along a radial direction. One end of the pushing ring stretches into the guide sleeve. A second elastic structure is between the pushing ring and guide sleeve. The other end of the pushing ring faces sides of the bayonet locks. Bump components are disposed on sides of the bayonet locks, with bump slots corresponding thereto. Clamping slots for insertion of the clamping portions are on an end face of the pushing ring.

Abstract: A device for rapidly loading and releasing a syringe. A limiting flange and clamping flange are on an outer side wall of an end, connected to the device, of the syringe. The clamping flange is close to a rear end of the syringe. The device includes an injection head. An outer collar, middle plate, and inner collar are sequentially inside the injection head. The outer collar includes an upper and lower part that are disposed up and down. The inner collar includes an upper part of the inner collar and a lower part of the inner collar that are disposed up and down. Elastic structures are between the upper part of the inner collar and injection head and between the lower part of the inner collar and injection head. The injector syringe can be loaded onto the device and taken out rapidly if the syringe is rotated.

Abstract: An apparatus includes a housing, a carrier, and an expandable assembly. The housing defines an opening configured to selectively place a gas chamber of the housing in fluid communication with an exterior volume. The carrier is movably disposed within the housing and is coupled to a medicament container. A proximal surface of the carrier defines a portion of a boundary of the gas chamber. The expandable assembly has a first member and a second member. The first member is coupled to an elastomeric member disposed within the medicament container, and the second member includes a valve portion. The expandable assembly transitions from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container. The valve portion moves relative to the opening when the expandable assembly transitions from the first to the second configuration, placing the gas chamber in fluid communication with the exterior volume.

Abstract: An apparatus includes a housing, an actuator, a lock mechanism, and a medicament container. The lock mechanism selectively engages a portion of the housing such that (1) the lock mechanism is maintained in a substantially fixed position when the housing is in a first orientation and (2) the lock mechanism is removable from the housing when the housing is in a second orientation. The medicament container is moved in a proximal direction when the lock mechanism is removed from the housing to mix a first medicament portion contained within the medicament container with a second medicament portion contained within the medicament container. The actuator can be moved from a first position to a second position when the lock mechanism is removed from the housing to release energy stored within an energy storage member such that the medicament container is moved in a distal direction.

Abstract: Provided is an administration apparatus for administering a dosing liquid. The administration apparatus includes a storage unit storing the dosing liquid, a drive unit imparting administration energy and a pressurization unit pressurizing the stored dosing liquid with the administration energy. The administration apparatus also includes an injection unit injecting the pressurized liquid to an object region through an injection port. In a pressure transition of the dosing liquid at the injection port, a vibration in the pressure transition reaches a converged state from a rising time of pressure. Furthermore, a ratio of a peak value of an initial vibration element to a peak value of subsequent vibration elements other than the first vibration element is higher than 1 and equal to or lower than a prescribed first ratio. As a result, invasiveness to the object region during administration is reduced.

Abstract: A package including a vessel wherein at least a portion of the vessel wall is made of a double wall material is disclosed. The double wall material comprises an interior polymer layer enclosed by an exterior polymer layer and one of the polymer layers is a layer made of cyclic olefin polymer (COP) resin. The package comprising the double wall, a CVD coating set on the wall, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

Abstract: The invention relates to a lubricant coating (5) for a medical injection device (1), comprising successively: —a bottom layer (50) in contact with the medical device surface (21) of the container to be lubricated, comprising a mixture of cross-linked and non-cross-linked poly-(dimethylsiloxane), —an intermediate layer (51) consisting essentially of oxidized poly-(dimethylsiloxane) and having a thickness comprised between 10 and 30 nm and, —a top layer (52) consisting essentially of non-cross-linked poly-(dimethylsiloxane) and having a thickness of at most 2 nm. The invention also relates to a medical injection device comprising such a lubricant coating, and a manufacturing process for said coating.