Abstract: The present invention relates to a filtering syringe, and more particularly, to an apparatus obtained by improving a syringe provided with a filter means for filtering foreign substances such as glass fragments of an ampoule, so as to prevent the foreign substances from being injected together with a liquid medicine while allowing the liquid medicine to be smoothly sucked and injected with a small force, especially even though a filter means having micro-pores is employed. The filtering syringe is configured such that the filter means is provided in the injection flow passage to prevent the foreign substances from being injected together with the liquid medicine while enabling the liquid medicine to be more smoothly sucked and injected despite employing the filter means having the micro-pores, thereby maximizing user's convenience and marketability of the syringe.

Abstract: An injection syringe device includes a tubular barrel, a plunger, and a piezo-chromic pressure indicator. The plunger has a distal tip and is designed to fit tightly and to reciprocate within the tubular barrel. Pulling the plunger out of the tubular barrel draws a liquid or a gas inside the tubular barrel in a space between the distal tip and a distal end of the tubular barrel and pushing the plunger into the tubular barrel expels the liquid or gas from the space. The piezo-chromic pressure indicator changes color to indicate pressure applied on the liquid or gas being expelled and/or target tissue being injected with the liquid or gas.

Abstract: The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rota-tion with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, movi

Abstract: Methods and systems for an injection system are provided. An example injection system includes a container for a pharmaceutical that is sealed at a proximal end with a plunger having a pushing surface for engaging an inner surface of the hollow body. A plunger rod extends axially from the proximal end of the container and is covered with a plunger rod cover. Removal of the cover activates the system and allows for delivery of the pharmaceutical product from the container by advancing the plunger within the container towards the seal.

Abstract: The disclosure relates to a drug delivery device for mechanically dispensing a dose of a medicament. The drug delivery device includes a ratchet mechanism adapted to emit an audible and/or tactile feedback during dispensing the dose of medicament. The ratchet mechanism includes a flexible arm and a toothed profile. A free end of the flexible arm is configured to engage with the toothed profile and to perform a relative rotational movement thereto during dispensing the dose of medicament, thereby generating the audible and/or tactile feedback, and the flexible arm extends in a plane parallel to a rotational axis of the flexible arm.

Abstract: The invention refers to a handheld injection device comprising a housing, a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing, a gauge element, which is at least partly interposed between the housing and the dose indicator, wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element. A contrast element having a first marking is provided and at least a region of the gauge element is provided with a second marking, with the first marking and/or the second marking being visible through a first window or aperture in the housing depending on the axial position of the gauge element within the housing.

Abstract: The present invention relates to a mounting aid (400) for attaching a supplementary device (2) to an injection device (1), wherein the injection device (1) has an elongated housing (10) extending in an axial direction (3, 4), the mounting aid (400) comprises: a body (401) extending in axial direction (3, 4), configured to receive at least a portion of the housing (10) and having at least one radially extending engaging member (406, 416) to engage with a correspondingly shaped engaging member (456) of the housing (10) when in a specific position (M) relative to the housing (10), and wherein the body (401) comprises a side wall (402) with an abutment face (410) facing in a proximal direction (4), wherein the abutment face (410) is defined on a plane that is inclined to the axial direction (3, 4).

Abstract: The present invention relates to a medicament delivery device comprising a housing, a compartment inside said housing for positioning a medicament container, an injection needle arranged to said housing, being connectable to said medicament container for delivering a dose of medicament, a manually operated activation mechanism for activating said device, an actuation mechanism operably connected to said activation mechanism and arranged to, upon activation of said activation mechanism, extend said injection needle from a first position inside said housing to a second position wherein a penetration of a patient is performed, a plunger rod arranged in said housing capable of acting on said medicament container for delivering a dose of medicament through said injection needle, a driver capable of acting on said plunger rod for delivering a dose of medicament.

Abstract: Exemplary embodiments provide a needle shield remover that reliably engages with a distal cap of an automatic injection device and with one or more needle shields coupled to a syringe of the device. When a user removes the distal cap, the needle shield remover reliably removes the needle shields (e.g., a soft needle shield and a rigid needle shield) from the syringe, thereby exposing the injection needle for performing an injection. In an exemplary assembly method, a needle shield remover is engaged to a needle shield coupled to a syringe, prior to insertion of the syringe and needle shield remover assembly into a housing of the device. This exemplary assembly method allows visual inspection, outside the housing of the device, to ensure that the needle shield remover is correctly and reliably engaged to the needle shield before the syringe and needle shield remover assembly is inserted into the housing.

Abstract: A nebulizer comprising a nebulizing chamber with a vibrating mesh grid having a plurality of precision openings and said chamber with a liquid pharmaceutical product in a cartridge contacting the mesh grid for producing particle sizes of two (2) to four (4) microns; and an entrainment port for drawing air into the nebulizing chamber and through the grid. A control circuit, a source of electrical energy in said circuit such as two 1.5 volt lithium titanate batteries connected to said grid for producing vibration. A switch to turn said grid off and on and means for providing a first measured time period of four seconds for taking a first breath of air through the entrainment port and grid and through the thousands of passageways into the lungs and bloodstream of an individual. A second time period during which no vibration occurs. The grid is also self-cleaning as described.

Abstract: A novel device for vaporization device is disclosed for frictionally engaging a water pipe having an input port and an inhalation aperture with a water pipe fluid pathway formed therebetween comprising. The device includes a electronic vaporization element (EVE) formed from an elongated hollow member having a first end and a second end for coupling with a water pipe input port. A heating element is disposed proximate the first end and powered by a removable electrical power source for being coupled with the water pipe using a frictional engagement mechanism. A first control circuit is electrically coupled with the electrical power source for providing electrical power from the electrical power source to the heating element for heating the phyto material to a predetermined temperature for causing vaporization thereof.

Abstract: A resuscitator has a patient airway interface device, a bag, a fluid passage coupled between the bag and patient airway interface device, and a sensor module. The patient airway interface device may be a mask or an endotracheal tube. The sensor module can have a display, at least one sensor coupled to the flow passage and configured to provide a measurement of at least one parameter, and a processor coupled to the display and the at least one sensor. The processor is configured to receive the measurement from the sensor and provide information on the display based on the received measurement. The information may include a current breath rate, a pressure-vs-time curve, and guidance to the user to assist in achieving a target breath rate.

Abstract: A mechanical ventilation device (10) includes a mechanical ventilator. At least one airway sensor (24, 26) is configured to measure at least one of airway pressure and airway air flow as a function of time for a patient on the mechanical ventilator. At least one microprocessor (28, 30) is programmed to analyze at least one of airway pressure and airway air flow measured by the airway sensor to detect a spontaneous respiration anomaly in respiratory muscle pressure as a function of time generated by a patient on the mechanical ventilator. A display component (22) is configured to display an indication of a spontaneous respiration anomaly detected by the anomaly detection component.

Abstract: A respiratory mask includes a mask frame and a soft mask pad. The mask frame includes a ring-shaped base which is disposed at the front end of the mask pad, and a pair of wing portions which are connected to two opposite sides of the ring-shaped base and each of which is formed with a free end face. The mask pad includes an abutting portion, and is transformable between a non-sealing state, where the abutting portion is separated from the free end faces, and a sealing state, where the abutting portion abuts against the free end faces.

Abstract: A mask frame, comprises a central conduit connection aperture and lateral arms having a 3-D curvature. The lateral arms extend: outwardly from a center of the frame, rearwardly, towards the patients ears, and upwardly, along a vector passing from below the nose to a point between the temple the top of the ear. The lateral arms “twist” along their length, such that a bottom margin of an end of each lateral arm is positioned further away from a notional vertical plane passing through the centre of the conduit connection aperture than a top margin. Also provided is an anti-rotation feature which limits or prevents rotation between straps of a headgear, and the mask frame. Further provided is a buckle for a closed loop headgear the buckle being formed with a plurality of openings and posts configured to form an angled headgear strap path through the buckle through which part of a headgear strap loop can pass.

Abstract: A patient interface for delivering breathable gas to a patient includes a foam interfacing portion adapted to provide a nasal interface to contact under and around the patient's nose in use and including an orifice adapted to surround both the patient's nares in use, and a positioning and stabilizing structure to support the foam interfacing portion in an operative position on the patient's face. The positioning and stabilizing structure is structured to provide a range of rotational, axial, and/or lateral movement to the foam interfacing portion while maintaining a sufficient interface and resisting the application of tube drag and/or headgear tension to the foam interfacing portion.

Abstract: The present invention pertains to a device (1) for the treatment of respiratory disorders or complications thereof in a mammal with a gaseous mixture for use as an inhalable medicament, comprising a patient interface (3), a source (23) of air, a source (21) of gaseous nitric oxide, a source (22) of gaseous oxygen, an application device (4) for providing a gaseous mixture to a patient interface, at least one gas injector (5) for injecting nitric oxide provided by the source of gaseous nitric oxide into the gaseous mixture provided by the application device, at least one gas injector (6) for injecting oxygen provided by the source of gaseous oxygen into the gaseous mixture provided by the application device, and a controller (8) programmed for controlling the at least one gas injector and the application device, wherein the source of gaseous nitric oxide comprises an arrangement (210) for onsite production of nitric oxide, and the source of gaseous oxygen comprises an arrangement (220) for onsite enrichment of

Abstract: A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can comprise a second tube, sliding within the drainage tube, or a slideable plug.

Abstract: In some examples, a catheter includes a catheter body including an outer jacket and an inner liner. The inner liner may include a proximal section including a proximal end of the inner liner and a distal section including a distal end of the inner liner. The distal section may include an inner liner defining a plurality of cuts. Each cut may extend at least partially through the liner wall. The one or more cuts defined in the liner wall of the distal section of the inner liner may increase a bending flexibility of the distal section relative to the proximal section of the inner liner, while maintaining a suitable tensile strength of the distal section.

Abstract: A hub is provided for a sheath, catheter, or other tubular device that includes a tubular body comprising a proximal end, a distal end, and a hub passage extending between the proximal end and the distal end; a valve mounted in the tubular body adjacent the proximal end comprising a proximal surface adjacent the proximal end and a distal surface adjacent an intermediate region of the hub passage; a side port comprising a first end coupled to an outer surface of the tubular body adjacent the intermediate region, a second outer end, and a port passage extending between the second end and the first end and communicating with the intermediate region of the hub passage; and a guide element in the side port adjacent the first end for directing fluid introduced into the second end through the port passage towards the distal surface of the valve.

Abstract: An elongate body extending from a proximal end to a distal end includes a core comprising an amorphous metal alloy and includes a sheath that comprises a crystalline metallic material. The sheath surrounds the core.

Abstract: A magnetic stylet includes a core element and a distal region. The core element may include a proximal end coupled to a tab, the proximal end having a first diameter, a transition region, and a distal region extending from the transition region to a distal end. The distal region may have a second diameter less than the first diameter. The distal section may include the transition region and the distal region of the core element, a magnetic element, a polymer member, and a closure element. The magnetic element may be positioned distal of the transition region of the core element. The polymer member may be circumferentially disposed about the distal region of the core element, the continuous permanent magnetic element, and at least a portion of the transition region of the core element. The closure element may be an epoxy that forms a rounded end distal of the polymer member.

Abstract: Deflectable apparatus and methods for performing a procedure within a patient's body using such apparatus are provided. Generally, the apparatus includes an elongate tubular member including a proximal end, a distal end, a longitudinal axis extending between the proximal and distal ends, a deflectable distal portion including first and second lumens spaced apart from one another on generally opposite sides of the longitudinal axis, and a handle coupled to the proximal end of the tubular member. A pull wire includes a loop disposed within the handle and first and second segments extending from the loop and slidably received in the first and second lumens, respectively, and coupled to the distal end. An actuator is provided on the handle for applying tension to either the first or the second segment to cause a distal portion of the tubular member to deflect, e.g., in opposite directions.

Abstract: Embodiments described herein are directed to tubing management members and urine collection systems including such tubing management members. In an embodiment, a tubing management member may be coupled and, in some embodiments, removably coupled to a drainage tube of the urine collection system. The tubing management member may include a plurality of attachment elements for attaching the tubing management member to the drainage tube.

Abstract: A device for snugging a balloon of a catheter against an inner wall of an intra-corporeal lumen or surface serviced by the catheter includes a hollow column having a top end and a bottom end, forming a throughway sized to accommodate a tube of the catheter, and a flange extending from the bottom end of the hollow column generally perpendicularly to length of the hollow column. A slit is formed in the hollow column and the flange through which the hollow column is connectable to the tube of the catheter. The catheter is tugged to contact the balloon to the inner wall of the lumen, and the device is fixed to the tube of the catheter atop the skin of a body serviced by the catheter to tension pressure of the balloon against the inner wall.

Abstract: A catheter assembly includes a catheter, a catheter hub fixed to the proximal end of the catheter, a needle positioned inside the catheter, a gripping member connected to a proximal portion of the inner needle, a catheter operating member connected to the catheter hub and movable in the longitudinal direction relative to the inner needle, a guide wire slidably positioned in the inner needle and possessing a length longer than both the inner needle and the catheter, and a wire operating member connected to the guide wire so that movement of the wire operating member results in movement of the guide wire. The catheter operating member is configured to press a portion of the catheter between the proximal end of the catheter and the distal end of the catheter when the user presses on the catheter operating member while puncturing a living body with the needlepoint.

Abstract: A needle tip shielding device, comprising a base plate with a hole extending there through from the proximal side of the base plate to the distal side of the base plate, and at least one resilient arm extending at an attachment point at said base plate (101) is provided. The resilient arm has a resting state wherein a distal hook of the resilient arm will coincide with a straight imaginary line extending longitudinally through said hole in the axial direction of said base plate. The resilient arm comprises a knob at its distal end, said knob extending laterally from the resilient arm. The knob is shaped with an outer curvature in the transversal plane around an axis parallel to the central axis of the needle tip shielding device and said knob is shaped with an outer curvature in the midsaggital plane around an axis perpendicular to the central axis of the needle tip shielding device.

Abstract: A guidewire retention clip is provided to prevent the accidental, complete insertion of a guidewire into a patient during various procedures. As provided herein, the guidewire retention clip may include a body having a portion configured to hold a guidewire; a sensor associated with the body configured to detect movement of the guidewire to and from the body; and an audio and/or visual indicator arranged on the body, wherein the audio and/or visual indicator is triggered when the sensor detects movement of the guidewire. Methods of using the guidewire retention clip are also provided.

Abstract: A method of inflating a catheter balloon may include providing a balloon assembly operable to provide a balloon diameter vs. balloon pressure profile generally depicting a balloon inflation sequence providing at least one intermediate inflated diameter and a final inflated diameter of a balloon such that the balloon attains the at least one intermediate diameter at a predetermined pressure, and attains the final diameter at a final predetermined pressure that is lower than a predetermined pressure of a last intermediate pressure.

Abstract: Described herein are methods and devices for delivering a drug to the frontal sinus system. An inflatable implant is positioned within the frontal sinus system using an anchoring means secured within the frontal sinus cavity. A drug-containing fluid is released directly into the frontal sinus drainage system.

Abstract: A medical balloon system can include a cage that can be used to control the outer diameter of the expanded balloon. This can be done to control features such as the maximum outer diameter, but also to better control drug exposure on the surface of the balloon.

Abstract: Medical devices and method for making and using medical devices are disclosed. An example method for treating a blood vessel may include disposing a medical device within the blood vessel at a position adjacent to a lesion. The medical device may comprise an elongate shaft having a distal end region, a balloon coupled to the distal end region, and a force transmitting member at least partially disposed at least partially within the balloon. The force transmitting member may be designed to transmit energy to the lesion. The method may also include inflating the balloon to a first pressure, actuating the force transmitting member to at least partial break apart the lesion, and inflating the balloon to a second pressure greater than the first pressure.

Abstract: A composite expandable medical balloon comprising a base balloon, the base balloon comprising a coextrusion, the coextrusion comprising an inner layer formed from an elastomeric polymer and an outer layer formed from a thermoplastic polymer a fiber braid disposed along the base balloon, the fiber braid comprising at least one polymeric fiber disposed over the base balloon, wherein the base balloon is designed to exhibit minimal delamination between the inner layer the outer layer of the base balloon, and methods of making the same.

Abstract: A cerebral spinal fluid shunt plug includes a shunt plug housing having a recess formed therein and a shunt valve shaped and dimensioned for positioning within the recess of the shunt plug housing.

Abstract: A dilation catheter system is provided to dilate the ostium of a paranasal sinus or some other anatomical passageway (e.g., within the ear, nose, or throat, etc.). The system may include a dilation catheter, a dilator, a guide catheter, and an inflator. The dilation catheter may be positioned between the dilator and the inflator. The guide catheter is configured to guide the dilator into the affected passageway. The inflator may then be actuated to transfer fluid from the inflator, through the dilation catheter, and into the dilator. The transfer of fluid may inflate the dilator to an expanded state to open or dilate the affected passageway. The inflator may include a body, a plunger assembly, and locking features that selectively secure the position of the plunger assembly relative to the body by moving along a path that is transverse to a longitudinal axis defined by the plunger assembly.

Abstract: A balloon for a balloon catheter has an inflatable, single-layer balloon envelope, which surrounds an interior and is dilatable by filling the interior with a fluid. The balloon envelope consists of polyamide 6.12 or includes or substantially consists of polyamide 6.12.

Abstract: A method of treating a sinus cavity of a subject includes advancing a distal portion of a light source through a drainage pathway of a sinus cavity and into the sinus cavity and visually observing a transdermal light emitted from the light source. A distal portion of a substantially rigid inner guide member of a balloon dilation catheter is advanced into the drainage pathway, the balloon dilation catheter including a movable shaft including a balloon that is slidably mounted on the substantially rigid inner guide member. The movable shaft and balloon are advanced distally over the substantially rigid inner guide member to place a portion of the balloon in the drainage pathway whereby the balloon is inflated.

Abstract: Systems and methods for treating target tissues within the ears are disclosed. Systems include a device including a cutting edge configured to form an incision in a tympanic membrane, a pressure equalization tube positionable within an interior space of the device in a compressed configuration and configured to expand into an expanded configuration when released from the interior space, and an elongate positioning element configured to release the pressure equalization tube from the interior space such that the pressure equalization tube is deployed in the incision formed in the tympanic membrane.

Abstract: The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: A storage and manual dispenser apparatus for dispensing a pharmaceutical liquid under atmospheric pressure. This apparatus retains the liquid in a controlled and stable environment during storage.

Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.

Abstract: The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Abstract: Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap.

Abstract: Disclosed herein are several embodiments of a reduced pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters. Certain embodiments are directed to connectors used to connect fluid passage tube used in transmitting negative pressure to a fabric channel used in a suction adapter.

Abstract: Disclosed herein are embodiments of a connector system for releasably connecting together tubes, for example medical tubing, and methods of making and using such a connector system, whereby the connector system includes a female coupler having a first passageway, a male coupler having a second passageway, a catch movably coupled to the female coupler, and a catch-receiving element coupled to the male coupler. The connector system further includes a release element movably coupled to the female coupler, whereby travel of the release element along or over a female coupler outer surface of the female coupler disengages the catch from the catch-receiving element to achieve a disconnected condition of the connector system. Further disclosed herein are embodiments of a connector system for releasably connecting together tubes, whereby the connector system includes at least one valve biased by a valve-biasing member disposed external to or outside of the fluid flow path.

Abstract: A connector caps that can reduce risk of accidentally removing the cap include a locking feature where outer housing is designed to prevent removal of the cap unless a downward force is applied to the cap with counter clockwise rotation. Structural elements making up the cap locking feature can be optimized or varied, for example to require application of more or less force, more or less downward movement, more or less rotational movement, and variations of other characteristics to facilitate intentional removal and/or to prevent unintentional removal of the cap from the needleless connector, and/or to facilitate securing of the cap on the needleless connector. Optionally, a needleless connector cap can include an outer housing providing holes or openings or vents such that air can pass through if the cap becomes lodged in air passage way.

Abstract: A wearable defibrillator includes a plurality of ECG electrodes removably attached to a patient and configured to sense a cardiac condition of the patient, and at least one therapy pad configured to deliver electrical therapy to the patient. The wearable defibrillator may include a microphone configured to receive an audio input and sense environmental noise and a speaker configured to output one or more alarms signaling that treatment is about to be provided to the patient. At least one processor of the wearable defibrillator is operatively connected to the plurality of ECG electrodes, the at least one therapy pad, a memory, and the at least one audio device. The at least one processor is configured to monitor the sensed cardiac condition and increase a volume of the one or more alarms when the microphone senses from the environmental noise that the wearable defibrillator is in a high noise environment.

Abstract: An exemplary monitoring system 1) receives a user input command to begin monitoring evoked responses that occur in response to acoustic stimulation during an insertion procedure in which a lead that is communicatively coupled to a cochlear implant is inserted into a cochlea of a patient, the lead having an array of intracochlear electrodes and an extracochlear electrode, the extracochlear electrode physically and communicatively coupled to a probe that is also communicatively coupled to the monitoring system, 2) directs, in response to the user input command, the cochlear implant to short an intracochlear electrode with the extracochlear electrode, 3) presents the acoustic stimulation to the patient, and 4) records the evoked responses that occur in response to the acoustic stimulation by using the intracochlear electrode to detect signals representative of the evoked responses and receiving the detected signals by way of the extracochlear electrode and the probe.

Abstract: In one example, a cochlear lead includes a flexible body, an array of electrodes in the flexible body, and a plurality of wires passing along the array of electrodes. The plurality of wires includes a flexural geometry between each pair of adjacent electrodes and a substantially straight geometry over the electrodes. A method for forming an electrode array with a reduced apical cross section is also provided.

Abstract: The disclosure relates to implantable probes. An implantable probe includes a sleeve capable of being wound around an elongate organ of cylindrical shape, and includes a sheet of elastically deformable material that supports at least one electrode. The sheet is prestressed in such a way as to allow it to self-wind from an initial position, in which the sheet is kept stressed in the deployed state, to a final position, in which the sheet is wound freely in a spiral to form a sleeve around the organ, with the first face, which supports the electrodes, being directed towards the inside. The sheet is delimited by an outer lateral edge of the sleeve after winding, an inner lateral edge of the sleeve after winding, and a first transverse edge and a second, opposite transverse edge. The sheet includes perforations located in proximity to the first and/or second transverse edge.